LIPT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The process of transferring lipoic acid to proteins is a two-step process. The first step is the activation of lipoic acid by lipoate-activating enzyme to form lipoyl-AMP. For the second step, the protein encoded by this gene transfers the lipoyl moiety to apoproteins. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 13. Read-through transcription also exists between this gene and the neighboring downstream mitochondrial ribosomal protein L30 (MRPL30) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.50798749
2behavioral response to nicotine (GO:0035095)4.16691656
3DNA double-strand break processing (GO:0000729)4.12962649
4folic acid metabolic process (GO:0046655)4.10668800
5mitotic metaphase plate congression (GO:0007080)4.09142255
6respiratory chain complex IV assembly (GO:0008535)4.08956200
7protein complex biogenesis (GO:0070271)4.02511190
8folic acid-containing compound biosynthetic process (GO:0009396)4.02024491
9glycine metabolic process (GO:0006544)3.89359032
10mitochondrial respiratory chain complex assembly (GO:0033108)3.84442628
11mitochondrial respiratory chain complex I assembly (GO:0032981)3.82177964
12NADH dehydrogenase complex assembly (GO:0010257)3.82177964
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82177964
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.73312623
15L-phenylalanine metabolic process (GO:0006558)3.73312623
16DNA replication checkpoint (GO:0000076)3.68614288
17piRNA metabolic process (GO:0034587)3.67249245
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.65990776
19L-phenylalanine catabolic process (GO:0006559)3.65990776
20cysteine metabolic process (GO:0006534)3.62934770
21cytochrome complex assembly (GO:0017004)3.62046704
22inositol phosphate catabolic process (GO:0071545)3.60230086
23inositol phosphate dephosphorylation (GO:0046855)3.58141044
24phosphorylated carbohydrate dephosphorylation (GO:0046838)3.58141044
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54616737
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53967553
27serine family amino acid catabolic process (GO:0009071)3.51661500
28purine nucleobase biosynthetic process (GO:0009113)3.49465946
29lysine catabolic process (GO:0006554)3.48181593
30lysine metabolic process (GO:0006553)3.48181593
31water-soluble vitamin biosynthetic process (GO:0042364)3.48073447
32L-fucose catabolic process (GO:0042355)3.47704996
33fucose catabolic process (GO:0019317)3.47704996
34L-fucose metabolic process (GO:0042354)3.47704996
35nucleobase biosynthetic process (GO:0046112)3.47061563
36one-carbon metabolic process (GO:0006730)3.45910037
37maturation of SSU-rRNA (GO:0030490)3.41991581
38* protein-cofactor linkage (GO:0018065)3.39246239
39serine family amino acid biosynthetic process (GO:0009070)3.38701403
40metaphase plate congression (GO:0051310)3.38521251
41chaperone-mediated protein transport (GO:0072321)3.38112515
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.37700379
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37594994
44ATP synthesis coupled proton transport (GO:0015986)3.37594994
45platelet dense granule organization (GO:0060155)3.35017811
46amino acid salvage (GO:0043102)3.34989371
47L-methionine salvage (GO:0071267)3.34989371
48L-methionine biosynthetic process (GO:0071265)3.34989371
49serine family amino acid metabolic process (GO:0009069)3.33854036
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.33853776
51preassembly of GPI anchor in ER membrane (GO:0016254)3.30417412
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.29616359
53sulfur amino acid catabolic process (GO:0000098)3.28458353
54urea cycle (GO:0000050)3.27775451
55urea metabolic process (GO:0019627)3.27775451
56sulfur amino acid biosynthetic process (GO:0000097)3.25734609
57protein deneddylation (GO:0000338)3.24225475
58ribosome assembly (GO:0042255)3.23730752
59regulation of glucokinase activity (GO:0033131)3.21651687
60regulation of hexokinase activity (GO:1903299)3.21651687
61glyoxylate metabolic process (GO:0046487)3.21270646
62protein neddylation (GO:0045116)3.20035699
63response to pheromone (GO:0019236)3.19745322
64L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15755907
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14746486
66aromatic amino acid family catabolic process (GO:0009074)3.14349646
67maturation of 5.8S rRNA (GO:0000460)3.13860522
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13574444
69tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13574444
70tetrahydrofolate metabolic process (GO:0046653)3.09195762
71proteasome assembly (GO:0043248)3.07940187
72ubiquinone metabolic process (GO:0006743)3.06567668
73bile acid biosynthetic process (GO:0006699)3.06466780
74negative regulation of DNA-dependent DNA replication (GO:2000104)3.06079769
75amino-acid betaine metabolic process (GO:0006577)3.05764431
76RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04102718
77S-adenosylmethionine metabolic process (GO:0046500)3.03658941
78pteridine-containing compound biosynthetic process (GO:0042559)3.02771571
79protein localization to kinetochore (GO:0034501)3.01048972
80regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99760251
81regulation of mitotic spindle checkpoint (GO:1903504)2.99760251
82peptidyl-histidine modification (GO:0018202)2.99235746
83folic acid-containing compound metabolic process (GO:0006760)2.99024257
84regulation of mitochondrial translation (GO:0070129)2.98289399
85protein K11-linked deubiquitination (GO:0035871)2.98157436
86nitrogen cycle metabolic process (GO:0071941)2.97054040
87methionine metabolic process (GO:0006555)2.94180697
88DNA replication initiation (GO:0006270)2.93766469
89methionine biosynthetic process (GO:0009086)2.91795845
90formation of translation preinitiation complex (GO:0001731)2.90947736
91negative regulation of telomere maintenance (GO:0032205)2.90243520
92mitotic chromosome condensation (GO:0007076)2.89586665
93attachment of spindle microtubules to kinetochore (GO:0008608)2.88574759
94polyol catabolic process (GO:0046174)2.87718506
95alpha-linolenic acid metabolic process (GO:0036109)2.86763166
96chromatin remodeling at centromere (GO:0031055)2.86464275
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.84464199
98termination of RNA polymerase III transcription (GO:0006386)2.84464199
99regulation of spindle organization (GO:0090224)2.84181714
100mannosylation (GO:0097502)2.83609162
101recombinational repair (GO:0000725)2.82761327
102electron transport chain (GO:0022900)2.82432585
103tRNA processing (GO:0008033)2.81193761
104double-strand break repair via homologous recombination (GO:0000724)2.79744163
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79452613
106sulfur amino acid metabolic process (GO:0000096)2.79322626
107kynurenine metabolic process (GO:0070189)2.79147488
108epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.78861432
109aspartate family amino acid biosynthetic process (GO:0009067)2.78817572
110synapsis (GO:0007129)2.78451940
111respiratory electron transport chain (GO:0022904)2.78194413
112triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.77059417
113anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77033132
114cellular ketone body metabolic process (GO:0046950)2.76224947
115establishment of chromosome localization (GO:0051303)2.76007157
116DNA strand elongation involved in DNA replication (GO:0006271)2.75914221
117negative regulation of fibrinolysis (GO:0051918)2.75700993
118fatty acid beta-oxidation (GO:0006635)2.75594728
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.75058603
120negative regulation of sister chromatid segregation (GO:0033046)2.75058603
121negative regulation of mitotic sister chromatid separation (GO:2000816)2.75058603
122negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75058603
123CENP-A containing nucleosome assembly (GO:0034080)2.74788904
124indolalkylamine metabolic process (GO:0006586)2.74586828
125aspartate family amino acid metabolic process (GO:0009066)2.74417552
126spindle checkpoint (GO:0031577)2.74406757
127mitotic nuclear envelope disassembly (GO:0007077)2.73867530
128tryptophan metabolic process (GO:0006568)2.73576627
129tryptophan catabolic process (GO:0006569)2.73319123
130indole-containing compound catabolic process (GO:0042436)2.73319123
131indolalkylamine catabolic process (GO:0046218)2.73319123
132negative regulation of chromosome segregation (GO:0051985)2.72295714
133rRNA modification (GO:0000154)2.71426935
134cullin deneddylation (GO:0010388)2.70446933
135dopamine transport (GO:0015872)2.69505517
136L-serine metabolic process (GO:0006563)2.69261752
137epithelial cilium movement (GO:0003351)2.69213696
138axoneme assembly (GO:0035082)2.68937534
139mitotic spindle assembly checkpoint (GO:0007094)2.68547524
140folic acid transport (GO:0015884)2.68405345
141magnesium ion transport (GO:0015693)2.68315304
142homocysteine metabolic process (GO:0050667)2.68109227
143pseudouridine synthesis (GO:0001522)2.67706454
144alpha-amino acid catabolic process (GO:1901606)2.67388547
145ribosome biogenesis (GO:0042254)2.67041824
146regulation of protein activation cascade (GO:2000257)2.66270195
147neural tube formation (GO:0001841)2.66143141
148mitotic spindle checkpoint (GO:0071174)2.66080154
149pantothenate metabolic process (GO:0015939)2.65288448
150DNA catabolic process, exonucleolytic (GO:0000738)2.64964102
151pteridine-containing compound metabolic process (GO:0042558)2.64933084
152fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.64606890
153GPI anchor metabolic process (GO:0006505)2.64188294
154regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.64146017
155protein K6-linked ubiquitination (GO:0085020)2.64128916
156fat-soluble vitamin biosynthetic process (GO:0042362)2.64015168
157regulation of nuclear cell cycle DNA replication (GO:0033262)2.63049619
158somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.63036841
159isotype switching (GO:0045190)2.63036841
160somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.63036841
161regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.62695099
162spindle assembly checkpoint (GO:0071173)2.62293702
163DNA strand elongation (GO:0022616)2.62190211
164DNA methylation involved in gamete generation (GO:0043046)2.62106701
165ubiquinone biosynthetic process (GO:0006744)2.60393250
166quinone biosynthetic process (GO:1901663)2.60393250
167ketone body metabolic process (GO:1902224)2.60018213
168negative regulation of fatty acid biosynthetic process (GO:0045717)2.58465322
169positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.57141993
170regulation of meiosis I (GO:0060631)2.56849581
171replication fork processing (GO:0031297)2.55105838
172intracellular protein transmembrane import (GO:0044743)2.53667611
173rRNA catabolic process (GO:0016075)2.53209387
174tRNA modification (GO:0006400)2.52881589
175regulation of cilium movement (GO:0003352)2.52866331
176adenosine metabolic process (GO:0046085)2.52313762
177regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.51778871
178proton transport (GO:0015992)2.50845666
179detection of light stimulus involved in sensory perception (GO:0050962)2.49111424
180detection of light stimulus involved in visual perception (GO:0050908)2.49111424
181protein prenylation (GO:0018342)2.48405173
182prenylation (GO:0097354)2.48405173
183hydrogen transport (GO:0006818)2.46100795

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.89352506
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.43344606
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.90690744
4ZNF274_21170338_ChIP-Seq_K562_Hela3.65452271
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.53918909
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45272113
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03680702
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.01739238
9* GABP_17652178_ChIP-ChIP_JURKAT_Human2.94726586
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88612166
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87433218
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.84424002
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.83208766
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.79702051
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78374800
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74688508
17VDR_22108803_ChIP-Seq_LS180_Human2.68031901
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.67814942
19IGF1R_20145208_ChIP-Seq_DFB_Human2.65859033
20AR_21909140_ChIP-Seq_LNCAP_Human2.56466854
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55877531
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49855628
23* FLI1_27457419_Chip-Seq_LIVER_Mouse2.48977932
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42391280
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40156548
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.37687236
27EGR1_23403033_ChIP-Seq_LIVER_Mouse2.37013011
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31722472
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28347444
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20750672
31EWS_26573619_Chip-Seq_HEK293_Human2.20390146
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.18744619
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10780042
34DCP1A_22483619_ChIP-Seq_HELA_Human2.09707556
35SALL1_21062744_ChIP-ChIP_HESCs_Human2.04605362
36XRN2_22483619_ChIP-Seq_HELA_Human2.03787416
37* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02207019
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00686953
39* VDR_23849224_ChIP-Seq_CD4+_Human2.00379721
40FUS_26573619_Chip-Seq_HEK293_Human1.99123354
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98870560
42GABP_19822575_ChIP-Seq_HepG2_Human1.98336000
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96603680
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95700560
45GBX2_23144817_ChIP-Seq_PC3_Human1.95104975
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95045630
47* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93123284
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91233584
49IRF1_19129219_ChIP-ChIP_H3396_Human1.89141508
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81534223
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.80927535
52FOXP3_21729870_ChIP-Seq_TREG_Human1.79005648
53* SRF_21415370_ChIP-Seq_HL-1_Mouse1.78570673
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73865138
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72218358
56P300_19829295_ChIP-Seq_ESCs_Human1.71306379
57TP53_22573176_ChIP-Seq_HFKS_Human1.67584540
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67448594
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66100942
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.65465370
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60361204
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59242087
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58134417
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57235080
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56906191
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56818600
67ER_23166858_ChIP-Seq_MCF-7_Human1.56450996
68* TTF2_22483619_ChIP-Seq_HELA_Human1.56335421
69TAF15_26573619_Chip-Seq_HEK293_Human1.53605207
70* RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52759280
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50755162
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50286392
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48754547
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48214482
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47687735
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46487674
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46090248
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45131582
79* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44940731
80* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41441592
81* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39557095
82* FOXA1_25329375_ChIP-Seq_VCAP_Human1.39557095
83KDM5A_27292631_Chip-Seq_BREAST_Human1.34900878
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33380354
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32623174
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32309398
87* NFE2_27457419_Chip-Seq_LIVER_Mouse1.30707193
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30705220
89* EZH2_27294783_Chip-Seq_NPCs_Mouse1.29363506
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28566335
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27779018
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26761380
93NANOG_19829295_ChIP-Seq_ESCs_Human1.26717487
94SOX2_19829295_ChIP-Seq_ESCs_Human1.26717487
95* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26143633
96CBP_20019798_ChIP-Seq_JUKART_Human1.25962686
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25962686
98MYC_18940864_ChIP-ChIP_HL60_Human1.24698543
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24627618
100KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23937534
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23206317
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21501299
103BCAT_22108803_ChIP-Seq_LS180_Human1.20407632
104HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20406249
105IRF8_22096565_ChIP-ChIP_GC-B_Human1.20154334
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18922786
107CIITA_25753668_ChIP-Seq_RAJI_Human1.18617586
108AR_20517297_ChIP-Seq_VCAP_Human1.17960451
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17627069
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.16837081
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14767876
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13810119
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13720907
114ELK1_19687146_ChIP-ChIP_HELA_Human1.12900125
115E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12627886
116NCOR_22424771_ChIP-Seq_293T_Human1.12592969
117GATA3_21878914_ChIP-Seq_MCF-7_Human1.09969757
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09497260
119ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08818006
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08154347
121GATA3_26560356_Chip-Seq_TH2_Human1.06838698
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05514249
123KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04746638
124TFEB_21752829_ChIP-Seq_HELA_Human1.03992225
125* CRX_20693478_ChIP-Seq_RETINA_Mouse1.03794013
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02669691
127NANOG_21062744_ChIP-ChIP_HESCs_Human1.02491086
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02158515
129* TCF4_23295773_ChIP-Seq_U87_Human1.01042512
130AR_25329375_ChIP-Seq_VCAP_Human1.01034774
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00634427
132TCF4_22108803_ChIP-Seq_LS180_Human1.00339980
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00071140
134TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99182712
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99099680
136STAT3_23295773_ChIP-Seq_U87_Human0.98606809
137ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98483140
138* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97462448
139SMAD4_21799915_ChIP-Seq_A2780_Human0.96373203
140CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96155677
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95540042
142* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95536939
143HOXB7_26014856_ChIP-Seq_BT474_Human0.95485529
144* STAT3_18555785_Chip-Seq_ESCs_Mouse0.95344416
145NOTCH1_21737748_ChIP-Seq_TLL_Human0.95262653
146* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95149589
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94631355
148NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94259699
149RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93000500
150CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92647236
151* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91919875
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91808479
153PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91788794
154ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91122016
155RUNX2_22187159_ChIP-Seq_PCA_Human0.91056859
156* P53_22387025_ChIP-Seq_ESCs_Mouse0.90822158
157CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90650099
158NANOG_18555785_Chip-Seq_ESCs_Mouse0.90565137
159POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90200294
160* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86674534
161ELK1_22589737_ChIP-Seq_MCF10A_Human0.86415794
162* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85454468
163FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84264989
164SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.83572904
165MYC_22102868_ChIP-Seq_BL_Human0.82985979
166ATF3_27146783_Chip-Seq_COLON_Human0.82114340
167PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81863475
168TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79323057
169PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79208084
170TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79096860
171NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78459697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.14805497
2MP0005360_urolithiasis4.59992699
3MP0003693_abnormal_embryo_hatching4.30621660
4MP0003806_abnormal_nucleotide_metabolis4.21344643
5MP0005365_abnormal_bile_salt4.10238787
6MP0005085_abnormal_gallbladder_physiolo4.07492781
7MP0003718_maternal_effect3.31227463
8MP0003123_paternal_imprinting3.16250967
9MP0008875_abnormal_xenobiotic_pharmacok3.01131658
10MP0004957_abnormal_blastocyst_morpholog2.85271766
11MP0003111_abnormal_nucleus_morphology2.75135734
12MP0010094_abnormal_chromosome_stability2.68038371
13MP0009840_abnormal_foam_cell2.53320697
14MP0003077_abnormal_cell_cycle2.41849587
15MP0009697_abnormal_copulation2.34304916
16MP0006072_abnormal_retinal_apoptosis2.34165211
17MP0006292_abnormal_olfactory_placode2.20972374
18MP0005645_abnormal_hypothalamus_physiol2.19931924
19MP0003646_muscle_fatigue2.18254400
20MP0005332_abnormal_amino_acid2.16135458
21MP0001529_abnormal_vocalization2.15195599
22MP0006054_spinal_hemorrhage2.14636519
23MP0001986_abnormal_taste_sensitivity2.14027857
24MP0010329_abnormal_lipoprotein_level2.06554556
25MP0002876_abnormal_thyroid_physiology1.97292301
26MP0008877_abnormal_DNA_methylation1.91811520
27MP0003011_delayed_dark_adaptation1.91479486
28MP0005084_abnormal_gallbladder_morpholo1.91135271
29MP0006036_abnormal_mitochondrial_physio1.89838227
30MP0003787_abnormal_imprinting1.88880075
31MP0008872_abnormal_physiological_respon1.88515064
32MP0005551_abnormal_eye_electrophysiolog1.86696026
33MP0004147_increased_porphyrin_level1.85373315
34MP0008932_abnormal_embryonic_tissue1.77444674
35MP0003186_abnormal_redox_activity1.74201227
36MP0000372_irregular_coat_pigmentation1.71865309
37MP0004142_abnormal_muscle_tone1.68384329
38MP0005253_abnormal_eye_physiology1.67932369
39MP0005451_abnormal_body_composition1.66835177
40MP0008058_abnormal_DNA_repair1.61983798
41MP0003252_abnormal_bile_duct1.60217114
42MP0001984_abnormal_olfaction1.59919518
43MP0002163_abnormal_gland_morphology1.58856228
44MP0009046_muscle_twitch1.58671516
45MP0001764_abnormal_homeostasis1.58539864
46MP0001968_abnormal_touch/_nociception1.58413541
47MP0002736_abnormal_nociception_after1.56364566
48MP0000609_abnormal_liver_physiology1.53846852
49MP0005075_abnormal_melanosome_morpholog1.53268256
50MP0005395_other_phenotype1.51050347
51MP0001730_embryonic_growth_arrest1.50495753
52MP0001905_abnormal_dopamine_level1.48114740
53MP0005379_endocrine/exocrine_gland_phen1.47646147
54MP0005670_abnormal_white_adipose1.46007488
55MP0005671_abnormal_response_to1.42448582
56MP0002638_abnormal_pupillary_reflex1.42188775
57MP0005646_abnormal_pituitary_gland1.39784313
58MP0009745_abnormal_behavioral_response1.38997851
59MP0008995_early_reproductive_senescence1.35669239
60MP0002822_catalepsy1.33416792
61MP0001119_abnormal_female_reproductive1.32925814
62MP0003283_abnormal_digestive_organ1.31744929
63MP0003195_calcinosis1.31455336
64MP0003221_abnormal_cardiomyocyte_apopto1.29929309
65MP0010368_abnormal_lymphatic_system1.27727908
66MP0002272_abnormal_nervous_system1.26091668
67MP0005319_abnormal_enzyme/_coenzyme1.25478623
68MP0003699_abnormal_female_reproductive1.25050649
69MP0010386_abnormal_urinary_bladder1.24130530
70MP0006035_abnormal_mitochondrial_morpho1.23879102
71MP0001666_abnormal_nutrient_absorption1.23846337
72MP0002118_abnormal_lipid_homeostasis1.22833918
73MP0002160_abnormal_reproductive_system1.22742096
74MP0003705_abnormal_hypodermis_morpholog1.19771654
75MP0002277_abnormal_respiratory_mucosa1.18744109
76MP0004043_abnormal_pH_regulation1.18215047
77MP0000653_abnormal_sex_gland1.17440134
78MP0002928_abnormal_bile_duct1.16253245
79MP0002210_abnormal_sex_determination1.16226537
80MP0001929_abnormal_gametogenesis1.15318826
81MP0005266_abnormal_metabolism1.13893720
82MP0000350_abnormal_cell_proliferation1.12308586
83MP0010352_gastrointestinal_tract_polyps1.10695510
84MP0005174_abnormal_tail_pigmentation1.10399911
85MP0006276_abnormal_autonomic_nervous1.10233547
86MP0005083_abnormal_biliary_tract1.10179479
87MP0002095_abnormal_skin_pigmentation1.09677623
88MP0001485_abnormal_pinna_reflex1.08236242
89MP0000569_abnormal_digit_pigmentation1.07742234
90MP0000598_abnormal_liver_morphology1.07384507
91MP0005380_embryogenesis_phenotype1.07031603
92MP0001672_abnormal_embryogenesis/_devel1.07031603
93MP0002938_white_spotting1.06656631
94MP0003880_abnormal_central_pattern1.06260017
95MP0005408_hypopigmentation1.06093912
96MP0003656_abnormal_erythrocyte_physiolo1.06057313
97MP0002102_abnormal_ear_morphology1.05691127
98MP0000631_abnormal_neuroendocrine_gland1.05464522
99MP0004885_abnormal_endolymph1.04901197
100MP0004019_abnormal_vitamin_homeostasis1.04500610
101MP0002269_muscular_atrophy1.04274296
102MP0003868_abnormal_feces_composition1.03787777
103MP0000427_abnormal_hair_cycle1.01165427
104MP0002080_prenatal_lethality0.98869546
105MP0003984_embryonic_growth_retardation0.97177435
106MP0002837_dystrophic_cardiac_calcinosis0.96599962
107MP0009643_abnormal_urine_homeostasis0.96018880
108MP0002088_abnormal_embryonic_growth/wei0.95864794
109MP0008057_abnormal_DNA_replication0.95702268
110MP0001697_abnormal_embryo_size0.95147081
111MP0001501_abnormal_sleep_pattern0.95080522
112MP0001145_abnormal_male_reproductive0.94626138
113MP0008007_abnormal_cellular_replicative0.94488330
114MP0004133_heterotaxia0.94434600
115MP0003786_premature_aging0.93490845
116MP0004145_abnormal_muscle_electrophysio0.92565372
117MP0001919_abnormal_reproductive_system0.92029423
118MP0005330_cardiomyopathy0.90831032
119MP0005376_homeostasis/metabolism_phenot0.89744591
120MP0005410_abnormal_fertilization0.88573139
121MP0001486_abnormal_startle_reflex0.87827681
122MP0002019_abnormal_tumor_incidence0.87603062
123MP0005386_behavior/neurological_phenoty0.86445693
124MP0004924_abnormal_behavior0.86445693
125MP0000358_abnormal_cell_content/0.86075652
126MP0001835_abnormal_antigen_presentation0.84491421
127MP0008260_abnormal_autophagy0.84315759
128MP0002693_abnormal_pancreas_physiology0.83617413
129MP0003567_abnormal_fetal_cardiomyocyte0.83335271
130MP0000490_abnormal_crypts_of0.82519255
131MP0002234_abnormal_pharynx_morphology0.82379616
132MP0003698_abnormal_male_reproductive0.82114715
133MP0004742_abnormal_vestibular_system0.82081961
134MP0002970_abnormal_white_adipose0.81122313
135MP0001542_abnormal_bone_strength0.81093151
136MP0002138_abnormal_hepatobiliary_system0.80304337
137MP0002085_abnormal_embryonic_tissue0.77460778
138MP0002572_abnormal_emotion/affect_behav0.76682997
139MP0002148_abnormal_hypersensitivity_rea0.76485867
140MP0005647_abnormal_sex_gland0.76168707
141MP0008775_abnormal_heart_ventricle0.75941023
142MP0003121_genomic_imprinting0.74777813
143MP0002229_neurodegeneration0.74382076
144MP0003136_yellow_coat_color0.73683021
145MP0001661_extended_life_span0.73095092
146MP0002067_abnormal_sensory_capabilities0.72580479
147MP0002971_abnormal_brown_adipose0.72124329
148MP0000647_abnormal_sebaceous_gland0.71658075
149MP0003122_maternal_imprinting0.71608597
150MP0009785_altered_susceptibility_to0.71587200
151MP0001970_abnormal_pain_threshold0.71308381
152MP0005377_hearing/vestibular/ear_phenot0.71161349
153MP0003890_abnormal_embryonic-extraembry0.70966903
154MP0004215_abnormal_myocardial_fiber0.70785869
155MP0001915_intracranial_hemorrhage0.70750723
156MP0009672_abnormal_birth_weight0.68718890
157MP0004084_abnormal_cardiac_muscle0.68285000
158MP0000639_abnormal_adrenal_gland0.68221101
159MP0002086_abnormal_extraembryonic_tissu0.66602406
160MP0002078_abnormal_glucose_homeostasis0.66048354
161MP0002161_abnormal_fertility/fecundity0.66003834
162MP0000313_abnormal_cell_death0.65464822
163MP0005220_abnormal_exocrine_pancreas0.64920141
164MP0005666_abnormal_adipose_tissue0.64213596
165MP0004197_abnormal_fetal_growth/weight/0.63734818
166MP0000750_abnormal_muscle_regeneration0.63431579
167MP0005584_abnormal_enzyme/coenzyme_acti0.61564963
168MP0005023_abnormal_wound_healing0.59848094
169MP0005636_abnormal_mineral_homeostasis0.59456118
170MP0002084_abnormal_developmental_patter0.58424211
171MP0005389_reproductive_system_phenotype0.57491801

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)4.53536671
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.45009954
3Deep venous thrombosis (HP:0002625)4.32986876
4Hypobetalipoproteinemia (HP:0003563)4.24664989
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.22826854
6Hyperglycinuria (HP:0003108)3.90010283
7Hyperammonemia (HP:0001987)3.86420740
8Hyperglycinemia (HP:0002154)3.80801657
9Hypoglycemic coma (HP:0001325)3.71555456
10Abnormality of serum amino acid levels (HP:0003112)3.70590145
11Pancreatic cysts (HP:0001737)3.70167374
12Abnormality of methionine metabolism (HP:0010901)3.54075188
13Increased hepatocellular lipid droplets (HP:0006565)3.48983026
14Abnormality of serine family amino acid metabolism (HP:0010894)3.43938594
15Abnormality of glycine metabolism (HP:0010895)3.43938594
16Pancreatic fibrosis (HP:0100732)3.40466531
17Abnormality of pyrimidine metabolism (HP:0004353)3.39980769
18Molar tooth sign on MRI (HP:0002419)3.32894503
19Abnormality of midbrain morphology (HP:0002418)3.32894503
20Abnormality of fatty-acid metabolism (HP:0004359)3.32594962
21Hypolipoproteinemia (HP:0010981)3.29375113
22Cerebral edema (HP:0002181)3.28917000
23Abnormality of dicarboxylic acid metabolism (HP:0010995)3.26788847
24Dicarboxylic aciduria (HP:0003215)3.26788847
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.25396018
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.24414296
27Lethargy (HP:0001254)3.23043596
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.15551293
29Xanthomatosis (HP:0000991)3.10100166
30Type II lissencephaly (HP:0007260)3.09264974
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.07368199
32Abnormality of alanine metabolism (HP:0010916)3.07368199
33Hyperalaninemia (HP:0003348)3.07368199
34True hermaphroditism (HP:0010459)3.06972968
35Acute encephalopathy (HP:0006846)3.03038124
36Birth length less than 3rd percentile (HP:0003561)3.00564819
37Premature ovarian failure (HP:0008209)2.99182082
38Methylmalonic acidemia (HP:0002912)2.98901960
39Abnormality of the renal cortex (HP:0011035)2.98844318
40Congenital stationary night blindness (HP:0007642)2.96257611
41Breast hypoplasia (HP:0003187)2.93679402
42Brushfield spots (HP:0001088)2.90200805
43Nephronophthisis (HP:0000090)2.89720255
44Secondary amenorrhea (HP:0000869)2.89193533
45Ketosis (HP:0001946)2.83675984
46Cortical dysplasia (HP:0002539)2.82436316
47Hepatic necrosis (HP:0002605)2.82411453
48Hypoalphalipoproteinemia (HP:0003233)2.82290608
49Medial flaring of the eyebrow (HP:0010747)2.79813079
50Hyperlipoproteinemia (HP:0010980)2.76248247
51Prolonged partial thromboplastin time (HP:0003645)2.74794226
52Abolished electroretinogram (ERG) (HP:0000550)2.73792322
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.73115473
54Abnormality of the anterior horn cell (HP:0006802)2.70041749
55Degeneration of anterior horn cells (HP:0002398)2.70041749
56Oral leukoplakia (HP:0002745)2.66379573
57Exertional dyspnea (HP:0002875)2.63196062
58Hypothermia (HP:0002045)2.59539779
59Spastic diplegia (HP:0001264)2.57905864
60Abnormality of the renal medulla (HP:0100957)2.53072603
61Hyperglycemia (HP:0003074)2.52908313
62Acute necrotizing encephalopathy (HP:0006965)2.52117301
63Megaloblastic anemia (HP:0001889)2.48938325
64Abnormality of the labia minora (HP:0012880)2.48225858
65Abnormality of nucleobase metabolism (HP:0010932)2.46635928
66Renal cortical cysts (HP:0000803)2.44045700
67Multiple enchondromatosis (HP:0005701)2.43798942
68Abnormal rod and cone electroretinograms (HP:0008323)2.43735574
69Colon cancer (HP:0003003)2.42634048
70Abnormal mitochondria in muscle tissue (HP:0008316)2.39480677
71Abnormality of glycolysis (HP:0004366)2.38413276
72Increased serum pyruvate (HP:0003542)2.38413276
73Attenuation of retinal blood vessels (HP:0007843)2.38393094
74Renal Fanconi syndrome (HP:0001994)2.35425929
75Fat malabsorption (HP:0002630)2.35163054
76Generalized aminoaciduria (HP:0002909)2.34001037
773-Methylglutaconic aciduria (HP:0003535)2.31838883
78Rhabdomyolysis (HP:0003201)2.31554265
79Complement deficiency (HP:0004431)2.29859162
80Chronic hepatic failure (HP:0100626)2.29328409
81Gout (HP:0001997)2.29167975
82Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26395727
83Aplastic anemia (HP:0001915)2.25857349
84CNS demyelination (HP:0007305)2.25801762
85Lactic acidosis (HP:0003128)2.25795432
86Increased CSF lactate (HP:0002490)2.25380065
87Male infertility (HP:0003251)2.22857926
88Progressive inability to walk (HP:0002505)2.22599335
89Abnormal cartilage morphology (HP:0002763)2.22399073
90Hyperbilirubinemia (HP:0002904)2.21903460
91Spastic paraparesis (HP:0002313)2.20716041
92Thyroiditis (HP:0100646)2.19382605
93Microretrognathia (HP:0000308)2.19054242
94Large for gestational age (HP:0001520)2.17624428
95Stomatitis (HP:0010280)2.17067133
96Abnormality of the intrinsic pathway (HP:0010989)2.16639693
97Cerebral hypomyelination (HP:0006808)2.14686637
98IgG deficiency (HP:0004315)2.13784761
99Abnormal drinking behavior (HP:0030082)2.12913386
100Polydipsia (HP:0001959)2.12913386
101Hepatocellular necrosis (HP:0001404)2.11595282
102Clitoromegaly (HP:0000057)2.11049258
103Increased intramyocellular lipid droplets (HP:0012240)2.10452495
104Abnormality of lateral ventricle (HP:0030047)2.09289204
105Ketoacidosis (HP:0001993)2.09112940
106Insulin-resistant diabetes mellitus (HP:0000831)2.07564937
107Decreased central vision (HP:0007663)2.07400165
108Optic disc pallor (HP:0000543)2.06076152
109Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05742225
110Increased serum lactate (HP:0002151)2.05278523
111Metabolic acidosis (HP:0001942)2.04247183
112Lipid accumulation in hepatocytes (HP:0006561)2.03519306
113Pendular nystagmus (HP:0012043)2.02992994
114Congenital primary aphakia (HP:0007707)2.02842558
115Congenital, generalized hypertrichosis (HP:0004540)2.02592341
116Nausea (HP:0002018)2.01093145
117Tubular atrophy (HP:0000092)2.00494583
118Abnormality of purine metabolism (HP:0004352)1.99963508
119Insulin resistance (HP:0000855)1.98814844
120Sclerocornea (HP:0000647)1.98755109
121Cerebellar dysplasia (HP:0007033)1.98183288
122Abnormality of urine glucose concentration (HP:0011016)1.97292940
123Glycosuria (HP:0003076)1.97292940
124Cystic liver disease (HP:0006706)1.96263127
125Abnormal biliary tract physiology (HP:0012439)1.95616777
126Bile duct proliferation (HP:0001408)1.95616777
127Patellar aplasia (HP:0006443)1.95488733
128Gait imbalance (HP:0002141)1.95322122
129Nephrogenic diabetes insipidus (HP:0009806)1.94809519
130Abnormality of the common coagulation pathway (HP:0010990)1.94463312
131Reticulocytopenia (HP:0001896)1.94056097
132Epidermoid cyst (HP:0200040)1.93947412
133Malnutrition (HP:0004395)1.93469706
134Long foot (HP:0001833)1.92676106
135Conjugated hyperbilirubinemia (HP:0002908)1.91861725
136Abnormality of vitamin B metabolism (HP:0004340)1.91244024
137Respiratory failure (HP:0002878)1.91225457
138Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91047958
139Progressive macrocephaly (HP:0004481)1.90345019
140Abnormality of macular pigmentation (HP:0008002)1.88826980
141Inability to walk (HP:0002540)1.88336285
142Myoglobinuria (HP:0002913)1.87019783
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86866335
144Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85789977
145Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85789977
146Methylmalonic aciduria (HP:0012120)1.85633699
147Hypomagnesemia (HP:0002917)1.85579441
148Hyperinsulinemic hypoglycemia (HP:0000825)1.83849046
149Severe combined immunodeficiency (HP:0004430)1.83638115
150Congenital hepatic fibrosis (HP:0002612)1.83463073
151Mitochondrial inheritance (HP:0001427)1.83263437
152Increased purine levels (HP:0004368)1.82138628
153Hyperuricemia (HP:0002149)1.82138628
154Death in infancy (HP:0001522)1.82097614
155Diastasis recti (HP:0001540)1.82003037
156Macrocytic anemia (HP:0001972)1.81581070
157Increased muscle lipid content (HP:0009058)1.81319925
158Retinal dysplasia (HP:0007973)1.80138670
159Steatorrhea (HP:0002570)1.80046623
160Lissencephaly (HP:0001339)1.79805752
161Aplasia/Hypoplasia of the tongue (HP:0010295)1.79147196
162Atrophy/Degeneration involving motor neurons (HP:0007373)1.78661303
163Absent/shortened dynein arms (HP:0200106)1.77789213
164Dynein arm defect of respiratory motile cilia (HP:0012255)1.77789213
165Hyperventilation (HP:0002883)1.77742582
166Stomach cancer (HP:0012126)1.76430303
167Hypoproteinemia (HP:0003075)1.76389210
168Abnormality of the pons (HP:0007361)1.76221105
169Abnormality of the vitamin B12 metabolism (HP:0004341)1.73931376
170Furrowed tongue (HP:0000221)1.73769046
171Panhypogammaglobulinemia (HP:0003139)1.72370623
172Aplasia/hypoplasia of the uterus (HP:0008684)1.71902435
173Anencephaly (HP:0002323)1.71894989
174Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70367306
175Abnormal protein N-linked glycosylation (HP:0012347)1.70367306
176Abnormal protein glycosylation (HP:0012346)1.70367306
177Abnormal glycosylation (HP:0012345)1.70367306
178Abnormality of renal resorption (HP:0011038)1.69515786
179Abnormality of B cell number (HP:0010975)1.68482073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.12563121
2BUB13.75205330
3BCKDK3.69569477
4BRAF3.35286556
5MAP4K23.34865043
6ACVR1B3.06817892
7TTK3.04876888
8EIF2AK12.96027298
9CDC72.90718183
10NME22.81815371
11ZAK2.66774831
12WEE12.53577459
13NUAK12.48859832
14ADRBK22.45839723
15NEK12.36903457
16EEF2K2.36839764
17PLK42.30304482
18ARAF2.21467532
19ERBB42.18500907
20MST42.16676389
21TAOK12.11903449
22GRK12.09006187
23MAP3K62.04070526
24TXK1.99071001
25NEK21.96593384
26PLK11.95283417
27BMPR1B1.92588511
28WNK31.78422620
29WNK41.74556603
30RAF11.70374422
31EIF2AK31.70263359
32STK38L1.67257505
33LATS21.63546886
34OXSR11.52596258
35PDK41.50078964
36PDK31.50078964
37DYRK31.49098523
38STK391.42158348
39RPS6KA41.38238259
40TSSK61.36686284
41MAP3K81.35500926
42PLK31.34305108
43MUSK1.34065984
44PLK21.33356839
45PKN21.29348269
46CASK1.28073594
47AKT31.27749393
48RPS6KB21.26687838
49CHEK21.24521126
50AURKB1.24499965
51TRIM281.22446306
52STK101.20773531
53STK161.18093120
54MOS1.17947808
55VRK21.12543180
56BRSK21.12358198
57INSRR1.07318826
58PASK1.07277073
59ERBB31.05499263
60IKBKB1.05115555
61AURKA1.04373408
62LATS11.03257430
63TEC1.01751593
64MAPKAPK31.01091025
65TAOK30.99302587
66MAPK130.98568444
67CDK40.98011585
68MAP2K70.97997544
69PINK10.96483132
70MKNK20.95607135
71TLK10.92247431
72MAP3K110.91839385
73MAPK110.90047122
74CSNK1G20.89542792
75VRK10.87929763
76PIM20.87633553
77TAF10.87578121
78KIT0.85050662
79DAPK20.84618119
80STK30.84092297
81ABL20.82441659
82ATR0.82327735
83PRKCI0.81690517
84PRKCE0.80201571
85FGFR20.79712335
86TRIB30.79660815
87FLT30.79473710
88CSNK1G30.79272626
89PNCK0.79121920
90CDK190.79035651
91ITK0.77655199
92ADRBK10.77405465
93PHKG10.76764194
94PHKG20.76764194
95CHEK10.76301139
96KSR20.74761550
97SCYL20.74197834
98CDK70.72924891
99MAP2K60.72707078
100ERN10.70625651
101EIF2AK20.69832228
102CDK30.68549981
103RPS6KA50.67797067
104TNIK0.66278124
105MAPK150.65301163
106MELK0.64916218
107BRSK10.64864466
108PIM10.64056917
109IKBKE0.63167862
110PRKCG0.60898350
111MAP2K30.60880135
112PRKCQ0.60869062
113SIK10.60087758
114TAOK20.59840037
115CCNB10.59772441
116DYRK20.59432331
117NLK0.59136604
118CSF1R0.57167268
119CDK80.56441153
120PAK30.55276914
121MKNK10.54511584
122CSNK1A1L0.53548310
123STK240.52975168
124SRPK10.51563729
125KSR10.51267078
126MAP2K40.51079493
127EPHA20.51037696
128OBSCN0.50604155
129PIK3CA0.49705920
130MAP3K50.49692581
131ATM0.49390338
132MAP3K120.49008168
133TIE10.47099464
134NEK90.45843235
135CDK20.45591446
136TNK20.45190013
137MAP3K40.44523481
138TESK20.44342144
139LRRK20.44052461
140CSNK2A10.43567476
141SYK0.43214625
142PRKD30.43043093
143MAP3K90.43031513
144BCR0.40872520
145CAMKK20.40866939
146CSNK2A20.39750786
147NME10.38555013
148PAK10.38206015
149PRKACA0.37101555
150TESK10.36734330
151CHUK0.36636722
152GRK70.36514618
153PDK20.35983008
154EPHA40.35202830
155IGF1R0.34723151
156TTN0.33958652
157MAP3K140.33272539
158PRKAA20.32161833
159RPS6KA10.31936451
160CSNK1G10.31795902
161CDK10.29722025
162SGK20.28831778
163TGFBR10.27715307
164ILK0.27560495

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.83064947
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52343876
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29389445
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.21292776
5Fatty acid degradation_Homo sapiens_hsa000712.18996200
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.16423297
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15618269
8One carbon pool by folate_Homo sapiens_hsa006702.14351863
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.14024221
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12104964
11Propanoate metabolism_Homo sapiens_hsa006402.09454771
12DNA replication_Homo sapiens_hsa030302.08935730
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04809219
14RNA polymerase_Homo sapiens_hsa030202.04689777
15Mismatch repair_Homo sapiens_hsa034302.03778946
16Vitamin B6 metabolism_Homo sapiens_hsa007502.01570070
17Arginine biosynthesis_Homo sapiens_hsa002201.98386014
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.98001679
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97138314
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93193604
21Proteasome_Homo sapiens_hsa030501.85468045
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.82106987
23Selenocompound metabolism_Homo sapiens_hsa004501.73941357
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72857226
25Pyruvate metabolism_Homo sapiens_hsa006201.72716039
26Biosynthesis of amino acids_Homo sapiens_hsa012301.72221042
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71921263
28Sulfur relay system_Homo sapiens_hsa041221.70505533
29Phototransduction_Homo sapiens_hsa047441.70446222
30RNA transport_Homo sapiens_hsa030131.69116847
31Folate biosynthesis_Homo sapiens_hsa007901.68169039
32Pyrimidine metabolism_Homo sapiens_hsa002401.64122238
33Butanoate metabolism_Homo sapiens_hsa006501.63651181
34Cell cycle_Homo sapiens_hsa041101.62532585
35Carbon metabolism_Homo sapiens_hsa012001.60112229
36Tryptophan metabolism_Homo sapiens_hsa003801.58829880
37Peroxisome_Homo sapiens_hsa041461.58788967
38Ribosome_Homo sapiens_hsa030101.56588924
39Nitrogen metabolism_Homo sapiens_hsa009101.51249785
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50126137
41Nucleotide excision repair_Homo sapiens_hsa034201.49959491
42Fatty acid metabolism_Homo sapiens_hsa012121.49101953
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48274751
44Primary immunodeficiency_Homo sapiens_hsa053401.47180426
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.45539651
46Collecting duct acid secretion_Homo sapiens_hsa049661.43993887
47Homologous recombination_Homo sapiens_hsa034401.43595677
48Caffeine metabolism_Homo sapiens_hsa002321.39618173
49Alzheimers disease_Homo sapiens_hsa050101.39514882
50beta-Alanine metabolism_Homo sapiens_hsa004101.37957188
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36820423
52RNA degradation_Homo sapiens_hsa030181.36228097
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34802970
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29748489
55Asthma_Homo sapiens_hsa053101.22946434
56Complement and coagulation cascades_Homo sapiens_hsa046101.16392435
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16082065
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12548723
59Base excision repair_Homo sapiens_hsa034101.12292646
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11962046
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10995698
62Type I diabetes mellitus_Homo sapiens_hsa049401.10191060
63PPAR signaling pathway_Homo sapiens_hsa033201.07215630
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03801277
65Spliceosome_Homo sapiens_hsa030401.03554071
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00919747
67Pentose phosphate pathway_Homo sapiens_hsa000300.99467296
68Cardiac muscle contraction_Homo sapiens_hsa042600.99409037
69Chemical carcinogenesis_Homo sapiens_hsa052040.98678730
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98360828
71Basal transcription factors_Homo sapiens_hsa030220.96754740
72Arginine and proline metabolism_Homo sapiens_hsa003300.94266389
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93514019
74Histidine metabolism_Homo sapiens_hsa003400.93066180
75Fanconi anemia pathway_Homo sapiens_hsa034600.89332919
76Ether lipid metabolism_Homo sapiens_hsa005650.89198149
77Purine metabolism_Homo sapiens_hsa002300.87876468
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.86687143
79Retinol metabolism_Homo sapiens_hsa008300.84072357
80Glutathione metabolism_Homo sapiens_hsa004800.82951585
81Phenylalanine metabolism_Homo sapiens_hsa003600.82301990
82Rheumatoid arthritis_Homo sapiens_hsa053230.82220970
83Allograft rejection_Homo sapiens_hsa053300.81575654
84Fatty acid elongation_Homo sapiens_hsa000620.80715857
85Taste transduction_Homo sapiens_hsa047420.80240158
86Starch and sucrose metabolism_Homo sapiens_hsa005000.78186901
87Tyrosine metabolism_Homo sapiens_hsa003500.76423937
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75448151
89p53 signaling pathway_Homo sapiens_hsa041150.75066575
90Nicotine addiction_Homo sapiens_hsa050330.75028459
91Graft-versus-host disease_Homo sapiens_hsa053320.74611557
92Autoimmune thyroid disease_Homo sapiens_hsa053200.72492143
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69834852
94Arachidonic acid metabolism_Homo sapiens_hsa005900.69447753
95Olfactory transduction_Homo sapiens_hsa047400.68855675
96Steroid biosynthesis_Homo sapiens_hsa001000.68344962
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.67524399
98Sulfur metabolism_Homo sapiens_hsa009200.67259794
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66221381
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.65282289
101* Metabolic pathways_Homo sapiens_hsa011000.64574949
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59138149
103Circadian rhythm_Homo sapiens_hsa047100.58432535
104Non-homologous end-joining_Homo sapiens_hsa034500.58004809
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56616834
106Huntingtons disease_Homo sapiens_hsa050160.56104210
107Fat digestion and absorption_Homo sapiens_hsa049750.55634829
108Linoleic acid metabolism_Homo sapiens_hsa005910.55277444
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55118289
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54885609
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52453535
112Parkinsons disease_Homo sapiens_hsa050120.52300494
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51343595
114Protein export_Homo sapiens_hsa030600.50825578
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50669312
116Fructose and mannose metabolism_Homo sapiens_hsa000510.49880261
117mRNA surveillance pathway_Homo sapiens_hsa030150.48306778
118Antigen processing and presentation_Homo sapiens_hsa046120.45990104
119Oocyte meiosis_Homo sapiens_hsa041140.42683753
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41869610
121Lysine degradation_Homo sapiens_hsa003100.41066185
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40428314
123Oxidative phosphorylation_Homo sapiens_hsa001900.39685811
124Fatty acid biosynthesis_Homo sapiens_hsa000610.38676598
125Galactose metabolism_Homo sapiens_hsa000520.38486494
126Glycerolipid metabolism_Homo sapiens_hsa005610.37907839
127Regulation of autophagy_Homo sapiens_hsa041400.37025198
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35598102
129Morphine addiction_Homo sapiens_hsa050320.35122368
130Staphylococcus aureus infection_Homo sapiens_hsa051500.34746612
131Vitamin digestion and absorption_Homo sapiens_hsa049770.33646429
132Bile secretion_Homo sapiens_hsa049760.31894685
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30350461
134ABC transporters_Homo sapiens_hsa020100.30106154
135Insulin secretion_Homo sapiens_hsa049110.30041593
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29429232

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »