LIX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of dendrite morphogenesis (GO:0050774)4.80114948
2neuron cell-cell adhesion (GO:0007158)4.71447321
3cell migration in hindbrain (GO:0021535)4.62619931
4neuronal action potential propagation (GO:0019227)4.59052321
5glutamate secretion (GO:0014047)4.53173564
6DNA double-strand break processing (GO:0000729)4.53058514
7synaptic vesicle exocytosis (GO:0016079)4.47298253
8vocalization behavior (GO:0071625)4.27827432
9kinetochore organization (GO:0051383)4.24016897
10neurofilament cytoskeleton organization (GO:0060052)4.20869964
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.18591199
12cell proliferation in forebrain (GO:0021846)4.12568301
13protein localization to synapse (GO:0035418)4.11592379
14peripheral nervous system neuron development (GO:0048935)4.04368241
15negative regulation of dendrite development (GO:2000171)4.02079960
16olfactory bulb development (GO:0021772)3.98628919
17positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.97462597
18kinetochore assembly (GO:0051382)3.97012827
19regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.96717938
20negative regulation of astrocyte differentiation (GO:0048712)3.95924230
21limb bud formation (GO:0060174)3.92668372
22pyrimidine nucleobase catabolic process (GO:0006208)3.92153314
23regulation of synaptic vesicle exocytosis (GO:2000300)3.91067182
24replication fork processing (GO:0031297)3.88891546
25synaptic vesicle maturation (GO:0016188)3.83110539
26innervation (GO:0060384)3.82190161
27calcium-mediated signaling using intracellular calcium source (GO:0035584)3.78917285
28otic vesicle formation (GO:0030916)3.78708410
29neuronal action potential (GO:0019228)3.77191689
30proline transport (GO:0015824)3.73888301
31membrane depolarization during action potential (GO:0086010)3.72183774
32regulation of timing of cell differentiation (GO:0048505)3.71202367
33detection of temperature stimulus involved in sensory perception (GO:0050961)3.68341632
34detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.68341632
35detection of temperature stimulus (GO:0016048)3.65253108
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.61894874
37regulation of synaptic vesicle transport (GO:1902803)3.61455828
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.60513780
39lateral sprouting from an epithelium (GO:0060601)3.59780962
40DNA ligation (GO:0006266)3.59578083
41neuron fate determination (GO:0048664)3.57220376
42chromatin remodeling at centromere (GO:0031055)3.57199789
43cerebral cortex radially oriented cell migration (GO:0021799)3.55766886
44regulation of development, heterochronic (GO:0040034)3.52021475
45somite development (GO:0061053)3.51972940
46intraciliary transport (GO:0042073)3.51157252
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.49920751
48metaphase plate congression (GO:0051310)3.48499038
49tongue development (GO:0043586)3.40047108
50positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.36386372
51resolution of meiotic recombination intermediates (GO:0000712)3.35029171
52response to auditory stimulus (GO:0010996)3.34085260
53CENP-A containing nucleosome assembly (GO:0034080)3.33569666
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31297475
55negative regulation of transcription regulatory region DNA binding (GO:2000678)3.31071940
56positive regulation of neuroblast proliferation (GO:0002052)3.30351738
57centriole replication (GO:0007099)3.29426072
58regulation of neuronal synaptic plasticity (GO:0048168)3.29073324
59neurotransmitter secretion (GO:0007269)3.27995150
60phenol-containing compound catabolic process (GO:0019336)3.23010429
61neurotransmitter-gated ion channel clustering (GO:0072578)3.22977687
62presynaptic membrane assembly (GO:0097105)3.22557405
63postsynaptic membrane organization (GO:0001941)3.22012293
64sister chromatid segregation (GO:0000819)3.21945956
65regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.21185426
66positive regulation of potassium ion transmembrane transport (GO:1901381)3.21117399
67neuromuscular synaptic transmission (GO:0007274)3.19375590
68cellular response to cholesterol (GO:0071397)3.17517323
69auditory behavior (GO:0031223)3.17252980
70regulation of glutamate receptor signaling pathway (GO:1900449)3.16732819
71exploration behavior (GO:0035640)3.16235856
72nonmotile primary cilium assembly (GO:0035058)3.14302281
73cell communication by electrical coupling (GO:0010644)3.13656604
74synapse assembly (GO:0007416)3.13418506
75histone exchange (GO:0043486)3.12781139
76locomotory exploration behavior (GO:0035641)3.11730441
77forebrain neuron differentiation (GO:0021879)3.11474223
78transmission of nerve impulse (GO:0019226)3.10668782
79negative regulation of homotypic cell-cell adhesion (GO:0034111)3.08787955
80maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08784378
81negative regulation of glial cell differentiation (GO:0045686)3.08717773
82radial glial cell differentiation (GO:0060019)3.08099563
83negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.07467653
84neuronal stem cell maintenance (GO:0097150)3.07363841
85regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.07357607
86glutamate receptor signaling pathway (GO:0007215)3.06345966
87mitotic metaphase plate congression (GO:0007080)3.06168766
88dopamine biosynthetic process (GO:0042416)3.05150150
89nucleobase catabolic process (GO:0046113)3.04069377
90regulation of vesicle fusion (GO:0031338)3.03956377
91positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03518131
92ionotropic glutamate receptor signaling pathway (GO:0035235)3.03304242
93mitotic sister chromatid segregation (GO:0000070)3.02569933
94cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02472419
95protein localization to kinetochore (GO:0034501)3.02273876
96neuron recognition (GO:0008038)3.01961838
97neuron-neuron synaptic transmission (GO:0007270)3.00506303
98cellular response to sterol (GO:0036315)3.00015886
99limb development (GO:0060173)3.00001173
100appendage development (GO:0048736)3.00001173
101synaptic vesicle endocytosis (GO:0048488)2.99881327
102cellular potassium ion homeostasis (GO:0030007)2.99329233
103neurotransmitter transport (GO:0006836)2.98538567
104regulation of non-canonical Wnt signaling pathway (GO:2000050)2.98243964
105cilium morphogenesis (GO:0060271)2.98212831
106synaptic transmission, glutamatergic (GO:0035249)2.97371257
107regulation of neurotransmitter secretion (GO:0046928)2.95629068
108retinal ganglion cell axon guidance (GO:0031290)2.92823958
109negative regulation of microtubule polymerization (GO:0031115)2.92511873
110regulation of synaptic transmission, glutamatergic (GO:0051966)2.91513283
111regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.91484738
112regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.89593600
113response to pain (GO:0048265)2.89238081
114membrane depolarization (GO:0051899)2.87895737
115epithelial cilium movement (GO:0003351)2.87595959
116presynaptic membrane organization (GO:0097090)2.87101383
117cholesterol biosynthetic process (GO:0006695)2.86773410
118layer formation in cerebral cortex (GO:0021819)2.86239197
119behavioral response to nicotine (GO:0035095)2.85742350
120regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85417234
121synaptic vesicle docking involved in exocytosis (GO:0016081)2.85186576
122regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.84500524
123regulation of long-term neuronal synaptic plasticity (GO:0048169)2.82612111
124positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.82554749
125behavioral response to pain (GO:0048266)2.82007227
126negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81736544
127cerebellar Purkinje cell differentiation (GO:0021702)2.80432399
128DNA topological change (GO:0006265)2.80231467
129regulation of neurotransmitter transport (GO:0051588)2.80198059
130axonal fasciculation (GO:0007413)2.78114526
131dopamine transport (GO:0015872)2.77737099
132negative regulation of calcium ion transport into cytosol (GO:0010523)2.77669052
133epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77595120
134regulation of excitatory postsynaptic membrane potential (GO:0060079)2.77312250
135establishment of protein localization to mitochondrial membrane (GO:0090151)2.77240511
136catecholamine transport (GO:0051937)2.76672044
137membrane repolarization (GO:0086009)2.76548238
138establishment of synaptic vesicle localization (GO:0097480)2.74877913
139synaptic vesicle transport (GO:0048489)2.74877913
140regulation of neurotransmitter levels (GO:0001505)2.73750387
141isoprenoid biosynthetic process (GO:0008299)2.73669195
142smoothened signaling pathway (GO:0007224)2.72834244
143alanine transport (GO:0032328)2.71792210
144establishment of mitochondrion localization (GO:0051654)2.71452424
145action potential (GO:0001508)2.71340667
146regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.71119117
147adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.71011063
148regulation of synapse structural plasticity (GO:0051823)2.70693162
149regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70623866
150phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.70264843
151synaptic transmission (GO:0007268)2.69429441
152regulation of synaptic plasticity (GO:0048167)2.68129964
153serotonin receptor signaling pathway (GO:0007210)2.67589987
154negative regulation of oligodendrocyte differentiation (GO:0048715)2.66844353
155microtubule depolymerization (GO:0007019)2.66582890
156serine family amino acid catabolic process (GO:0009071)2.66066576
157negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.65910775
158negative regulation of translation, ncRNA-mediated (GO:0040033)2.65910775
159regulation of translation, ncRNA-mediated (GO:0045974)2.65910775
160L-serine metabolic process (GO:0006563)2.65185280
161cilium assembly (GO:0042384)2.64557320
162cilium organization (GO:0044782)2.64129896
163establishment of chromosome localization (GO:0051303)2.59580692
164recombinational repair (GO:0000725)2.56818538
165regulation of DNA endoreduplication (GO:0032875)2.56278396
166sterol biosynthetic process (GO:0016126)2.55480707
167negative regulation of DNA-dependent DNA replication (GO:2000104)2.55182136
168spindle checkpoint (GO:0031577)2.54439586
169regulation of astrocyte differentiation (GO:0048710)2.54016470
170neural tube formation (GO:0001841)2.53878891
171double-strand break repair via homologous recombination (GO:0000724)2.51915671
172microtubule polymerization or depolymerization (GO:0031109)2.50630437
173DNA replication-independent nucleosome organization (GO:0034724)2.50536713
174DNA replication-independent nucleosome assembly (GO:0006336)2.50536713
175detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50420821
176mechanosensory behavior (GO:0007638)2.47870936
177protein K6-linked ubiquitination (GO:0085020)2.47278884
178regulation of glial cell differentiation (GO:0045685)2.46920265
179negative regulation of DNA recombination (GO:0045910)2.46832822
180meiotic chromosome segregation (GO:0045132)2.45641960
181positive regulation of neural precursor cell proliferation (GO:2000179)2.45459423
182regulation of oligodendrocyte differentiation (GO:0048713)2.44057006
183cilium movement (GO:0003341)2.43112726
184embryonic digestive tract morphogenesis (GO:0048557)2.43081952
185translesion synthesis (GO:0019985)2.42812499
186sequestering of actin monomers (GO:0042989)2.41634737
187histone H2A acetylation (GO:0043968)2.41533511
188DNA replication checkpoint (GO:0000076)2.41075838
189postreplication repair (GO:0006301)2.40748907
190regulation of centriole replication (GO:0046599)2.40419718
191cerebral cortex cell migration (GO:0021795)2.40207396
192axon ensheathment in central nervous system (GO:0032291)2.39601018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05932156
2GBX2_23144817_ChIP-Seq_PC3_Human3.83568408
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24915283
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.20928144
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.19278645
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13070575
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12108869
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10785427
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79146518
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.70733618
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68576700
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68551733
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68551733
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.64831988
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.62145563
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.57164419
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53589805
18TAF15_26573619_Chip-Seq_HEK293_Human2.51744398
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41188147
20EWS_26573619_Chip-Seq_HEK293_Human2.38056221
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36386108
22REST_21632747_ChIP-Seq_MESCs_Mouse2.32754351
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32556675
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15598280
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.15300528
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12022375
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05536015
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.03869936
29POU5F1_16153702_ChIP-ChIP_HESCs_Human2.03864057
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99240473
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97833223
32* P300_19829295_ChIP-Seq_ESCs_Human1.93553701
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92805835
34AR_21572438_ChIP-Seq_LNCaP_Human1.92464056
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89400826
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.87118698
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.86310194
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.84421514
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83092256
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79593819
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77232468
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75198962
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73010328
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72355095
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.69482192
46IGF1R_20145208_ChIP-Seq_DFB_Human1.65632158
47VDR_22108803_ChIP-Seq_LS180_Human1.62936329
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61502697
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59605003
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.58756390
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57322740
52* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55538761
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55522688
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.54557698
55DROSHA_22980978_ChIP-Seq_HELA_Human1.53531702
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53353106
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52000356
58ELK1_19687146_ChIP-ChIP_HELA_Human1.51400150
59* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51058224
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.49187673
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47862323
62E2F7_22180533_ChIP-Seq_HELA_Human1.47445280
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47044455
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46671317
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45022946
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.43788298
67AR_25329375_ChIP-Seq_VCAP_Human1.43340644
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42193519
69RNF2_27304074_Chip-Seq_NSC_Mouse1.40371811
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40132685
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39817528
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39561494
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.36141786
74IRF1_19129219_ChIP-ChIP_H3396_Human1.35129177
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.34366948
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.33997279
77STAT3_23295773_ChIP-Seq_U87_Human1.32457764
78MYC_18940864_ChIP-ChIP_HL60_Human1.29920412
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.29191069
80JUN_21703547_ChIP-Seq_K562_Human1.28429354
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27809363
82* BCAT_22108803_ChIP-Seq_LS180_Human1.26778348
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.26693558
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.26002994
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25171687
86SOX9_26525672_Chip-Seq_HEART_Mouse1.21617934
87* PRDM14_20953172_ChIP-Seq_ESCs_Human1.18683604
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18028597
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16853131
90ZNF274_21170338_ChIP-Seq_K562_Hela1.16530893
91AR_21909140_ChIP-Seq_LNCAP_Human1.16073736
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.15855855
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.15567716
94RUNX2_22187159_ChIP-Seq_PCA_Human1.14602957
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.14283587
96TP53_18474530_ChIP-ChIP_U2OS_Human1.13076752
97* TCF4_22108803_ChIP-Seq_LS180_Human1.12744449
98TCF4_23295773_ChIP-Seq_U87_Human1.11303753
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.10748902
100AHR_22903824_ChIP-Seq_MCF-7_Human1.09908563
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09870942
102FUS_26573619_Chip-Seq_HEK293_Human1.09808566
103TP63_19390658_ChIP-ChIP_HaCaT_Human1.09721689
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08462726
105KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08193313
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07936026
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.07807441
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07761215
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07590703
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07412389
111* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06440126
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06057529
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05934751
114CBP_20019798_ChIP-Seq_JUKART_Human1.05366894
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05366894
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05181781
117AR_19668381_ChIP-Seq_PC3_Human1.05139326
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04768685
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04254971
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04005477
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03978064
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02728277
123NANOG_16153702_ChIP-ChIP_HESCs_Human1.02394397
124YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01942791
125* TAL1_26923725_Chip-Seq_HPCs_Mouse1.00748769
126NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00033350
127ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98977202
128CMYC_18555785_Chip-Seq_ESCs_Mouse0.96218936
129KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95538821
130RING1B_27294783_Chip-Seq_NPCs_Mouse0.95322349
131LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94764760
132* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94703919
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.94363094
134NFE2_27457419_Chip-Seq_LIVER_Mouse0.94132629
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94115401
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94115401
137* KDM2B_26808549_Chip-Seq_REH_Human0.94083226
138FLI1_21867929_ChIP-Seq_TH2_Mouse0.93332159
139ER_23166858_ChIP-Seq_MCF-7_Human0.93164053
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92818857
141PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92790157
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.92565436
143P53_22387025_ChIP-Seq_ESCs_Mouse0.92006385
144RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91812727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception4.67328484
2MP0001968_abnormal_touch/_nociception4.52791871
3MP0004859_abnormal_synaptic_plasticity4.27794341
4MP0000566_synostosis4.24850223
5MP0002736_abnormal_nociception_after4.21989170
6MP0004270_analgesia4.11849627
7MP0003880_abnormal_central_pattern3.98929749
8MP0003136_yellow_coat_color3.60700777
9MP0002734_abnormal_mechanical_nocicepti3.28567954
10MP0006276_abnormal_autonomic_nervous3.25129928
11MP0004858_abnormal_nervous_system3.23948373
12MP0010030_abnormal_orbit_morphology3.17868249
13MP0002733_abnormal_thermal_nociception3.10626212
14MP0003635_abnormal_synaptic_transmissio3.07636274
15MP0005248_abnormal_Harderian_gland3.03070776
16MP0002938_white_spotting3.01537581
17MP0001970_abnormal_pain_threshold2.66049921
18MP0008789_abnormal_olfactory_epithelium2.65352305
19MP0001986_abnormal_taste_sensitivity2.65013198
20MP0009745_abnormal_behavioral_response2.63773273
21MP0002063_abnormal_learning/memory/cond2.48260913
22MP0002272_abnormal_nervous_system2.40705832
23MP0009046_muscle_twitch2.38980411
24MP0002064_seizures2.36421538
25MP0002572_abnormal_emotion/affect_behav2.28767395
26MP0002822_catalepsy2.27566731
27MP0001293_anophthalmia2.26815328
28MP0002067_abnormal_sensory_capabilities2.17100701
29MP0001905_abnormal_dopamine_level2.09043063
30MP0001486_abnormal_startle_reflex2.03903136
31MP0001346_abnormal_lacrimal_gland2.02608181
32MP0002102_abnormal_ear_morphology2.01667842
33MP0002184_abnormal_innervation2.01556060
34MP0000778_abnormal_nervous_system1.87010989
35MP0001984_abnormal_olfaction1.86983312
36MP0010094_abnormal_chromosome_stability1.85741314
37MP0005253_abnormal_eye_physiology1.84982829
38MP0001440_abnormal_grooming_behavior1.82948143
39MP0002653_abnormal_ependyma_morphology1.82483713
40MP0005423_abnormal_somatic_nervous1.81357980
41MP0001188_hyperpigmentation1.78215516
42MP0005646_abnormal_pituitary_gland1.75863951
43MP0006072_abnormal_retinal_apoptosis1.75346357
44MP0001348_abnormal_lacrimal_gland1.75032134
45MP0002234_abnormal_pharynx_morphology1.74451877
46MP0003937_abnormal_limbs/digits/tail_de1.72521730
47MP0001529_abnormal_vocalization1.67713681
48MP0003329_amyloid_beta_deposits1.65850761
49MP0003938_abnormal_ear_development1.63383837
50MP0002233_abnormal_nose_morphology1.62595155
51MP0001501_abnormal_sleep_pattern1.61470488
52MP0002557_abnormal_social/conspecific_i1.56840184
53MP0000955_abnormal_spinal_cord1.55961925
54MP0005391_vision/eye_phenotype1.55927706
55MP0002751_abnormal_autonomic_nervous1.55768893
56MP0004811_abnormal_neuron_physiology1.54283194
57MP0003121_genomic_imprinting1.50097781
58MP0005386_behavior/neurological_phenoty1.47877797
59MP0004924_abnormal_behavior1.47877797
60MP0002638_abnormal_pupillary_reflex1.46631095
61MP0008058_abnormal_DNA_repair1.46286544
62MP0003011_delayed_dark_adaptation1.45524120
63MP0000537_abnormal_urethra_morphology1.42756765
64MP0000428_abnormal_craniofacial_morphol1.42475548
65MP0002882_abnormal_neuron_morphology1.40253361
66MP0009053_abnormal_anal_canal1.38352681
67MP0002282_abnormal_trachea_morphology1.32563981
68MP0003755_abnormal_palate_morphology1.32374379
69MP0002909_abnormal_adrenal_gland1.32202130
70MP0002697_abnormal_eye_size1.32137601
71MP0001286_abnormal_eye_development1.31956531
72MP0008569_lethality_at_weaning1.31491374
73MP0002092_abnormal_eye_morphology1.31124999
74MP0005645_abnormal_hypothalamus_physiol1.26270513
75MP0005195_abnormal_posterior_eye1.24620675
76MP0004133_heterotaxia1.24511067
77MP0000647_abnormal_sebaceous_gland1.24054674
78MP0010386_abnormal_urinary_bladder1.23375960
79MP0008877_abnormal_DNA_methylation1.22360214
80MP0001177_atelectasis1.18703680
81MP0002066_abnormal_motor_capabilities/c1.17301544
82MP0003633_abnormal_nervous_system1.15444645
83MP0003183_abnormal_peptide_metabolism1.12793147
84MP0003878_abnormal_ear_physiology1.12368451
85MP0005377_hearing/vestibular/ear_phenot1.12368451
86MP0003119_abnormal_digestive_system1.10209058
87MP0005187_abnormal_penis_morphology1.06512937
88MP0002111_abnormal_tail_morphology1.05917278
89MP0001502_abnormal_circadian_rhythm1.05555492
90MP0004142_abnormal_muscle_tone1.04948620
91MP0003631_nervous_system_phenotype1.04607196
92MP0002752_abnormal_somatic_nervous1.04391412
93MP0004742_abnormal_vestibular_system1.02789190
94MP0003890_abnormal_embryonic-extraembry1.01859423
95MP0005409_darkened_coat_color1.01320586
96MP0005379_endocrine/exocrine_gland_phen1.00224266
97MP0002928_abnormal_bile_duct0.99791022
98MP0003122_maternal_imprinting0.98613342
99MP0001963_abnormal_hearing_physiology0.98603275
100MP0003634_abnormal_glial_cell0.95404221
101MP0002090_abnormal_vision0.95016651
102MP0000372_irregular_coat_pigmentation0.94361036
103MP0008057_abnormal_DNA_replication0.94325372
104MP0008932_abnormal_embryonic_tissue0.93249329
105MP0005171_absent_coat_pigmentation0.92430157
106MP0003077_abnormal_cell_cycle0.91735766
107MP0002152_abnormal_brain_morphology0.91066989
108MP0002249_abnormal_larynx_morphology0.90337259
109MP0002229_neurodegeneration0.90268054
110MP0009780_abnormal_chondrocyte_physiolo0.90022276
111MP0008872_abnormal_physiological_respon0.89690942
112MP0001324_abnormal_eye_pigmentation0.87943735
113MP0002163_abnormal_gland_morphology0.87147169
114MP0003111_abnormal_nucleus_morphology0.86643025
115MP0003567_abnormal_fetal_cardiomyocyte0.85734410
116MP0009250_abnormal_appendicular_skeleto0.85608785
117MP0001485_abnormal_pinna_reflex0.85328917
118MP0003693_abnormal_embryo_hatching0.84587777
119MP0009697_abnormal_copulation0.84451625
120MP0000026_abnormal_inner_ear0.83726853
121MP0000516_abnormal_urinary_system0.83666836
122MP0005367_renal/urinary_system_phenotyp0.83666836
123MP0000427_abnormal_hair_cycle0.82531399
124MP0009703_decreased_birth_body0.81916028
125MP0000579_abnormal_nail_morphology0.81721489
126MP0002138_abnormal_hepatobiliary_system0.81370556
127MP0002837_dystrophic_cardiac_calcinosis0.81255697
128MP0003879_abnormal_hair_cell0.80822291
129MP0000631_abnormal_neuroendocrine_gland0.79954610
130MP0009379_abnormal_foot_pigmentation0.79730987
131MP0000538_abnormal_urinary_bladder0.79413548
132MP0002932_abnormal_joint_morphology0.78798011
133MP0001270_distended_abdomen0.78406469
134MP0002116_abnormal_craniofacial_bone0.76728587
135MP0002109_abnormal_limb_morphology0.75723634
136MP0003718_maternal_effect0.75698157
137MP0004885_abnormal_endolymph0.75631702
138MP0001929_abnormal_gametogenesis0.74626431
139MP0001664_abnormal_digestion0.74021049
140MP0003385_abnormal_body_wall0.73879190
141MP0003698_abnormal_male_reproductive0.73409592
142MP0001299_abnormal_eye_distance/0.72495782
143MP0003632_abnormal_nervous_system0.72120750
144MP0002069_abnormal_eating/drinking_beha0.71640561
145MP0008874_decreased_physiological_sensi0.69942328
146MP0005535_abnormal_body_temperature0.69671596
147MP0000751_myopathy0.68242310
148MP0004085_abnormal_heartbeat0.68110503
149MP0005551_abnormal_eye_electrophysiolog0.66517398
150MP0003787_abnormal_imprinting0.65514653
151MP0000049_abnormal_middle_ear0.65506152
152MP0005499_abnormal_olfactory_system0.62982342
153MP0005394_taste/olfaction_phenotype0.62982342
154MP0000604_amyloidosis0.62375022
155MP0008260_abnormal_autophagy0.62362164
156MP0003137_abnormal_impulse_conducting0.61973513
157MP0002876_abnormal_thyroid_physiology0.59693886
158MP0004147_increased_porphyrin_level0.58432146
159MP0006292_abnormal_olfactory_placode0.58027660
160MP0004215_abnormal_myocardial_fiber0.56469529
161MP0004145_abnormal_muscle_electrophysio0.55735214
162MP0001943_abnormal_respiration0.53632092
163MP0003861_abnormal_nervous_system0.52627089
164MP0000534_abnormal_ureter_morphology0.51118515

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.47134980
2Focal motor seizures (HP:0011153)5.77428628
3Hypothermia (HP:0002045)4.81619114
4Ulnar claw (HP:0001178)4.59721170
5Action tremor (HP:0002345)4.49366376
6Focal seizures (HP:0007359)4.41804977
7Febrile seizures (HP:0002373)4.32555263
8Pheochromocytoma (HP:0002666)4.16518541
9Limb dystonia (HP:0002451)4.05818188
10Progressive cerebellar ataxia (HP:0002073)4.00618805
11Atonic seizures (HP:0010819)3.99334049
12Epileptic encephalopathy (HP:0200134)3.96901086
13Neuroendocrine neoplasm (HP:0100634)3.89053639
14Termporal pattern (HP:0011008)3.65678304
15Insidious onset (HP:0003587)3.65678304
16True hermaphroditism (HP:0010459)3.60546095
17Abnormality of the labia minora (HP:0012880)3.55827010
18Ankle clonus (HP:0011448)3.52855332
19Pancreatic fibrosis (HP:0100732)3.38343908
20Visual hallucinations (HP:0002367)3.31928311
21Supranuclear gaze palsy (HP:0000605)3.31750080
22Abnormality of midbrain morphology (HP:0002418)3.26058161
23Molar tooth sign on MRI (HP:0002419)3.26058161
24Pancreatic cysts (HP:0001737)3.18637732
25Absence seizures (HP:0002121)3.16059282
26Generalized tonic-clonic seizures (HP:0002069)3.12277508
27Dialeptic seizures (HP:0011146)2.99240343
28Nephronophthisis (HP:0000090)2.97486922
29Volvulus (HP:0002580)2.94478296
30Amblyopia (HP:0000646)2.93185856
31Septo-optic dysplasia (HP:0100842)2.92198060
32Hyperventilation (HP:0002883)2.86655196
33Megalencephaly (HP:0001355)2.79254775
34Dysautonomia (HP:0002459)2.77078781
35Short 4th metacarpal (HP:0010044)2.75721996
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.75721996
37Oligodactyly (HP:0012165)2.72452719
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.68725111
39Abnormality of pain sensation (HP:0010832)2.65501049
40Impaired pain sensation (HP:0007328)2.65501049
41Ectopic kidney (HP:0000086)2.64455655
42Hemivertebrae (HP:0002937)2.63394546
43Esophageal atresia (HP:0002032)2.61880838
44Hyperglycinemia (HP:0002154)2.61388792
45Colon cancer (HP:0003003)2.58940446
46Truncal ataxia (HP:0002078)2.57596756
47Medial flaring of the eyebrow (HP:0010747)2.56042326
48Gastrointestinal atresia (HP:0002589)2.55971035
49Abnormality of the renal medulla (HP:0100957)2.53705353
50Abnormal lung lobation (HP:0002101)2.53668566
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.52965057
52Sclerocornea (HP:0000647)2.51848264
53Fetal akinesia sequence (HP:0001989)2.51050051
54Meckel diverticulum (HP:0002245)2.50970984
55Vitreoretinal degeneration (HP:0000655)2.50387671
56Lower limb muscle weakness (HP:0007340)2.48850258
57Hammertoe (HP:0001765)2.48582143
58Anxiety (HP:0000739)2.47685010
59Spastic gait (HP:0002064)2.47171004
60Preaxial hand polydactyly (HP:0001177)2.46401020
61Intestinal atresia (HP:0011100)2.46216999
62Abnormality of the ileum (HP:0001549)2.45442259
63Postaxial foot polydactyly (HP:0001830)2.44810546
64Abnormal autonomic nervous system physiology (HP:0012332)2.42041146
65Aplasia involving bones of the upper limbs (HP:0009823)2.41400855
66Aplasia of the phalanges of the hand (HP:0009802)2.41400855
67Aplasia involving bones of the extremities (HP:0009825)2.41400855
68Oligodactyly (hands) (HP:0001180)2.40347290
69Nuclear cataract (HP:0100018)2.37606225
70Impaired vibration sensation in the lower limbs (HP:0002166)2.36201391
71Steppage gait (HP:0003376)2.34265455
72Postaxial hand polydactyly (HP:0001162)2.34000733
73Urinary bladder sphincter dysfunction (HP:0002839)2.31877028
74Gait imbalance (HP:0002141)2.31649331
75Triphalangeal thumb (HP:0001199)2.31229957
76Hemiparesis (HP:0001269)2.30360062
77Abnormality of the 4th metacarpal (HP:0010012)2.28617458
78Aplasia/Hypoplasia of the sternum (HP:0006714)2.27390344
79Failure to thrive in infancy (HP:0001531)2.27315679
80Cystic liver disease (HP:0006706)2.26677356
81Renal hypoplasia (HP:0000089)2.26052119
82Retinal dysplasia (HP:0007973)2.25612457
83Abnormality of chromosome stability (HP:0003220)2.24373181
84Abnormality of the corticospinal tract (HP:0002492)2.24221747
85Hypoplastic pelvis (HP:0008839)2.24018278
86Anencephaly (HP:0002323)2.23506115
87Absent septum pellucidum (HP:0001331)2.23179945
88Rib fusion (HP:0000902)2.22790915
89Abnormality of the phalanges of the 2nd finger (HP:0009541)2.22511795
90Optic nerve hypoplasia (HP:0000609)2.21959307
91Neoplasm of the peripheral nervous system (HP:0100007)2.20193088
92Bradycardia (HP:0001662)2.19714285
93Genital tract atresia (HP:0001827)2.16710938
94Preaxial foot polydactyly (HP:0001841)2.16119621
95Myotonia (HP:0002486)2.16113120
96Hypoventilation (HP:0002791)2.15864734
97Drooling (HP:0002307)2.14883817
98Excessive salivation (HP:0003781)2.14883817
99Dysmetria (HP:0001310)2.14371368
100Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.14316830
101Congenital primary aphakia (HP:0007707)2.13302902
102Anophthalmia (HP:0000528)2.11976181
103Chronic hepatic failure (HP:0100626)2.11751614
104Abnormal eating behavior (HP:0100738)2.09945819
105Delusions (HP:0000746)2.09515002
106Split foot (HP:0001839)2.08537631
107Depression (HP:0000716)2.08454424
108Trigonocephaly (HP:0000243)2.08024008
109Progressive inability to walk (HP:0002505)2.07530212
110Abnormality of the parathyroid morphology (HP:0011766)2.06812254
111Urinary urgency (HP:0000012)2.06564200
112Neurofibrillary tangles (HP:0002185)2.06432711
113Abnormal hair whorl (HP:0010721)2.05906629
114Holoprosencephaly (HP:0001360)2.05477938
115Sloping forehead (HP:0000340)2.05299725
116Segmental peripheral demyelination/remyelination (HP:0003481)2.04602587
117Abnormality of the metopic suture (HP:0005556)2.04063055
118Paraplegia (HP:0010550)2.03361123
119Aplasia/Hypoplasia of the tibia (HP:0005772)2.02881708
120Acute necrotizing encephalopathy (HP:0006965)2.02468472
121Vaginal atresia (HP:0000148)2.00916541
122Abnormality of the diencephalon (HP:0010662)2.00728371
123Aqueductal stenosis (HP:0002410)2.00663017
124Broad-based gait (HP:0002136)1.99991532
125Abnormality of the middle phalanges of the toes (HP:0010183)1.99827606
126Hypoplasia of the brainstem (HP:0002365)1.99275584
127Aplasia/Hypoplasia of the brainstem (HP:0007362)1.99275584
128Cerebral inclusion bodies (HP:0100314)1.99154039
129Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.98673930
130Exotropia (HP:0000577)1.98539658
131Cutaneous finger syndactyly (HP:0010554)1.97579413
132Short tibia (HP:0005736)1.97567172
133Hypoplastic labia majora (HP:0000059)1.96685945
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95596515
135Chromsome breakage (HP:0040012)1.94316799
136Epileptiform EEG discharges (HP:0011182)1.93954559
137Occipital encephalocele (HP:0002085)1.93569018
138Partial duplication of thumb phalanx (HP:0009944)1.92046485
139Nephrogenic diabetes insipidus (HP:0009806)1.91661426
140Bradykinesia (HP:0002067)1.91506194
141Narrow forehead (HP:0000341)1.90068379
142Hypercortisolism (HP:0001578)1.89848895
143Zonular cataract (HP:0010920)1.87703305
144Abnormality of binocular vision (HP:0011514)1.87370795
145Diplopia (HP:0000651)1.87370795
146Progressive macrocephaly (HP:0004481)1.87155908
147Abnormality of glycine metabolism (HP:0010895)1.87059061
148Abnormality of serine family amino acid metabolism (HP:0010894)1.87059061
149EEG with generalized epileptiform discharges (HP:0011198)1.86994668
150Inability to walk (HP:0002540)1.85889754
151Absent speech (HP:0001344)1.85770589
152Synostosis involving the elbow (HP:0003938)1.85515249
153Humeroradial synostosis (HP:0003041)1.85515249
154Abnormality of calcium-phosphate metabolism (HP:0100530)1.85346716
155Cerebellar dysplasia (HP:0007033)1.85317280
156Menstrual irregularities (HP:0000858)1.85200602
157Gaze-evoked nystagmus (HP:0000640)1.84908611
158Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84813418
159Abnormality of the duodenum (HP:0002246)1.83719303
160Abnormality of the septum pellucidum (HP:0007375)1.83533821
161Polyphagia (HP:0002591)1.82679556
162Dandy-Walker malformation (HP:0001305)1.82489637
163Dysdiadochokinesis (HP:0002075)1.82346246
164Bifid tongue (HP:0010297)1.82206831
165Degeneration of the lateral corticospinal tracts (HP:0002314)1.81837245
166Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81837245
167Cutaneous syndactyly (HP:0012725)1.81413565
168Abnormality of the proximal phalanges of the hand (HP:0009834)1.80910073
169Small intestinal stenosis (HP:0012848)1.80333676
170Duodenal stenosis (HP:0100867)1.80333676
171Specific learning disability (HP:0001328)1.80265733
172Thyroid carcinoma (HP:0002890)1.79904642
173High anterior hairline (HP:0009890)1.77938715
174Facial hemangioma (HP:0000329)1.77605429
175Hyperglycinuria (HP:0003108)1.77184046
176Glioma (HP:0009733)1.77105418
177Aganglionic megacolon (HP:0002251)1.76924128
178Stenosis of the external auditory canal (HP:0000402)1.76832495
179Hypoplastic female external genitalia (HP:0012815)1.75488692
180Supernumerary spleens (HP:0009799)1.74948800
181Hypsarrhythmia (HP:0002521)1.74426201
182Labial hypoplasia (HP:0000066)1.74132233
183Abnormality of the labia majora (HP:0012881)1.73967082
184Abnormal mitochondria in muscle tissue (HP:0008316)1.73817989
185Broad foot (HP:0001769)1.73626897
186Type II lissencephaly (HP:0007260)1.73572447
187Foot dorsiflexor weakness (HP:0009027)1.73291493
188Bile duct proliferation (HP:0001408)1.73025365
189Abnormal biliary tract physiology (HP:0012439)1.73025365

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.64408016
2NTRK34.30622868
3WNK33.60105550
4WEE13.33191694
5EPHA43.32212980
6MINK13.27923655
7LMTK22.92892960
8PLK42.73233550
9NTRK12.57870655
10MAP3K122.53222483
11MAP2K72.46508835
12MAP3K92.44793683
13BUB12.40195531
14GRK52.37508198
15MAP3K42.32028088
16NEK12.24483740
17SIK32.17281555
18FGFR22.09912475
19MARK12.09316865
20BRSK22.08963575
21NUAK12.08603758
22ERBB31.91826001
23TRIM281.91640736
24PLK21.91288313
25PLK31.88408315
26MKNK11.84418145
27PHKG11.82304671
28PHKG21.82304671
29MAPK131.80426113
30FRK1.75769595
31RIPK41.74896062
32KSR21.70105428
33SGK21.67379515
34CDC71.66943403
35SGK4941.64821586
36SGK2231.64821586
37MAP2K41.53078459
38MAP4K21.51461220
39TSSK61.43116718
40NTRK21.42084299
41CCNB11.39265965
42ZAK1.37995990
43LATS21.35708578
44DAPK21.35630767
45ARAF1.33339667
46TTK1.32406666
47ACVR1B1.31718326
48MAPK151.31559140
49VRK11.25602145
50NEK21.23552178
51PRKCG1.20954663
52PRPF4B1.20440250
53CDK51.19829565
54PAK61.19774364
55LIMK11.19271342
56GRK71.18583062
57KSR11.18182565
58TGFBR11.18056503
59PLK11.16829371
60PKN11.10490742
61MAP3K21.09479396
62PRKD31.07857290
63TNIK1.05407271
64SRPK10.99425680
65SGK30.98218385
66CAMK2A0.98159490
67OBSCN0.97693870
68VRK20.97553118
69INSRR0.97100918
70BRSK10.95131240
71NME10.94634739
72YES10.93210517
73RET0.91352820
74ADRBK10.91114029
75PNCK0.91064927
76BCKDK0.89442278
77PRKCE0.87674713
78FER0.87045833
79AKT30.86881359
80CSNK1G20.85486539
81MAP2K10.83791360
82MAP3K10.81168759
83CDK140.81034814
84ATR0.78961502
85BCR0.78158400
86DYRK30.77347452
87DAPK10.76915145
88PTK2B0.75396485
89STK30.74492310
90BMPR20.74123485
91PIK3CA0.73566505
92CDK180.73136720
93CSNK1A1L0.73072957
94CDK30.71757566
95MAP3K100.71255501
96BMPR1B0.69605796
97FGFR10.66412372
98MATK0.65929480
99DYRK1A0.63855619
100AURKB0.63101798
101CAMKK20.62122478
102CAMKK10.61709046
103MUSK0.61667832
104ATM0.61449923
105FGR0.61263591
106FES0.61241470
107CDK150.60655773
108STK38L0.60221472
109UHMK10.59718964
110ADRBK20.59693090
111CSNK1G30.59623198
112MAPKAPK50.58848147
113CAMK2B0.57954135
114RPS6KA20.57856317
115IRAK10.56459239
116PINK10.55969821
117NLK0.55074333
118ERBB20.54832219
119STK390.54798454
120CHEK20.54634227
121NEK90.53664365
122BRD40.53179101
123SGK10.53139841
124CAMK2D0.52885711
125CDK11A0.51571837
126STK160.49642270
127ROCK20.49460556
128CSNK1G10.49232577
129DYRK20.48503918
130EIF2AK30.48426001
131WNK40.48324787
132WNK10.48024323
133MAP3K130.47794461
134TNK20.46824072
135PRKACA0.46802657
136CAMK2G0.46259156
137GRK10.46227280
138PAK30.46155472
139SIK20.44180112
140EIF2AK20.42943934
141BRAF0.41451336
142PRKCH0.40286849
143PBK0.39344583
144RPS6KA40.38706084
145MKNK20.38365312
146DMPK0.37877665
147PRKCZ0.37334381
148EPHB20.36507479
149PRKDC0.35415462
150CSNK1A10.35356512
151IRAK20.35352486
152ROCK10.35139325
153CAMK1G0.35080643
154OXSR10.34680474
155CHEK10.32982639
156MAPK100.32895089
157LATS10.32446650
158CDK10.31665447
159PRKCB0.30782963
160PRKCA0.29853632
161EPHA30.29213218
162STK240.27702005

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.39428111
2Nicotine addiction_Homo sapiens_hsa050333.36816323
3Fanconi anemia pathway_Homo sapiens_hsa034603.21643654
4Homologous recombination_Homo sapiens_hsa034402.76362688
5Non-homologous end-joining_Homo sapiens_hsa034502.65569268
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.56941850
7Olfactory transduction_Homo sapiens_hsa047402.54522012
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38251347
9Amphetamine addiction_Homo sapiens_hsa050312.38116104
10Glutamatergic synapse_Homo sapiens_hsa047242.33006446
11Circadian entrainment_Homo sapiens_hsa047132.31652183
12Propanoate metabolism_Homo sapiens_hsa006402.30229972
13Dopaminergic synapse_Homo sapiens_hsa047282.29554889
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.29043362
15Taste transduction_Homo sapiens_hsa047422.28544342
16Long-term potentiation_Homo sapiens_hsa047202.23798159
17Basal cell carcinoma_Homo sapiens_hsa052172.17706421
18Protein export_Homo sapiens_hsa030602.14670387
19Mismatch repair_Homo sapiens_hsa034302.14206618
20GABAergic synapse_Homo sapiens_hsa047272.10890663
21Morphine addiction_Homo sapiens_hsa050322.09165512
22Serotonergic synapse_Homo sapiens_hsa047262.06311526
23Insulin secretion_Homo sapiens_hsa049112.05728564
24Butanoate metabolism_Homo sapiens_hsa006502.02312274
25Nitrogen metabolism_Homo sapiens_hsa009102.00727025
26Salivary secretion_Homo sapiens_hsa049701.99297995
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97320832
28Oxidative phosphorylation_Homo sapiens_hsa001901.96858915
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91931354
30Cholinergic synapse_Homo sapiens_hsa047251.91907009
31Cocaine addiction_Homo sapiens_hsa050301.91857711
32Collecting duct acid secretion_Homo sapiens_hsa049661.88067639
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85349608
34Parkinsons disease_Homo sapiens_hsa050121.77684890
35DNA replication_Homo sapiens_hsa030301.69665306
36Gastric acid secretion_Homo sapiens_hsa049711.61489953
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55562527
38Alzheimers disease_Homo sapiens_hsa050101.52673284
39Calcium signaling pathway_Homo sapiens_hsa040201.52482338
40Cell cycle_Homo sapiens_hsa041101.50820904
41Hippo signaling pathway_Homo sapiens_hsa043901.49936866
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48448317
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48313612
44Renin secretion_Homo sapiens_hsa049241.46782544
45Long-term depression_Homo sapiens_hsa047301.43781719
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.39174940
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.38403322
48Cardiac muscle contraction_Homo sapiens_hsa042601.38362114
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35898439
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35339485
51Base excision repair_Homo sapiens_hsa034101.34957079
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34724251
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33379419
54Basal transcription factors_Homo sapiens_hsa030221.31346509
55Dorso-ventral axis formation_Homo sapiens_hsa043201.29249011
56RNA degradation_Homo sapiens_hsa030181.26136564
57Melanogenesis_Homo sapiens_hsa049161.24590797
58Nucleotide excision repair_Homo sapiens_hsa034201.24586420
59GnRH signaling pathway_Homo sapiens_hsa049121.23083860
60Gap junction_Homo sapiens_hsa045401.21479440
61Spliceosome_Homo sapiens_hsa030401.20354806
62Oxytocin signaling pathway_Homo sapiens_hsa049211.17952131
63RNA polymerase_Homo sapiens_hsa030201.13996064
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.13060417
65Vibrio cholerae infection_Homo sapiens_hsa051101.11912724
66Huntingtons disease_Homo sapiens_hsa050161.11692270
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10673085
68Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08774221
69Tryptophan metabolism_Homo sapiens_hsa003801.06659754
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05720014
71Axon guidance_Homo sapiens_hsa043601.03145672
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02168536
73Phototransduction_Homo sapiens_hsa047441.00962181
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98614746
75Peroxisome_Homo sapiens_hsa041460.96782222
76cAMP signaling pathway_Homo sapiens_hsa040240.96557156
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96444345
78Fatty acid metabolism_Homo sapiens_hsa012120.95175588
79RNA transport_Homo sapiens_hsa030130.93194043
80beta-Alanine metabolism_Homo sapiens_hsa004100.91598860
81Lysine degradation_Homo sapiens_hsa003100.90362584
82Pyruvate metabolism_Homo sapiens_hsa006200.88562632
83TGF-beta signaling pathway_Homo sapiens_hsa043500.87984219
84Oocyte meiosis_Homo sapiens_hsa041140.87938978
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85214017
86Estrogen signaling pathway_Homo sapiens_hsa049150.84464112
87Glioma_Homo sapiens_hsa052140.84115553
88Caffeine metabolism_Homo sapiens_hsa002320.81635599
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81332679
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.79555143
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79092119
92ErbB signaling pathway_Homo sapiens_hsa040120.79069597
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.77483600
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77170687
95Fatty acid degradation_Homo sapiens_hsa000710.76236200
96Fatty acid biosynthesis_Homo sapiens_hsa000610.74948360
97p53 signaling pathway_Homo sapiens_hsa041150.73279305
98Linoleic acid metabolism_Homo sapiens_hsa005910.72649486
99Pancreatic secretion_Homo sapiens_hsa049720.71933455
100Selenocompound metabolism_Homo sapiens_hsa004500.71642139
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71148174
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70383376
103African trypanosomiasis_Homo sapiens_hsa051430.68250614
104mRNA surveillance pathway_Homo sapiens_hsa030150.66723239
105Thyroid hormone synthesis_Homo sapiens_hsa049180.66421625
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.66194806
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.66168020
108Alcoholism_Homo sapiens_hsa050340.63896629
109Proteasome_Homo sapiens_hsa030500.62883865
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60148882
111Glucagon signaling pathway_Homo sapiens_hsa049220.58503802
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58318310
113Choline metabolism in cancer_Homo sapiens_hsa052310.58208758
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.56270880
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56030380
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55252518
117Mineral absorption_Homo sapiens_hsa049780.54719718
118Histidine metabolism_Homo sapiens_hsa003400.54282391
119Purine metabolism_Homo sapiens_hsa002300.54028694
120MAPK signaling pathway_Homo sapiens_hsa040100.53879286
121Melanoma_Homo sapiens_hsa052180.53492836
122Pyrimidine metabolism_Homo sapiens_hsa002400.52263506
123Glycerolipid metabolism_Homo sapiens_hsa005610.52196833
124Ras signaling pathway_Homo sapiens_hsa040140.51910664
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51083151
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50488034
127Retinol metabolism_Homo sapiens_hsa008300.49905176
128Rap1 signaling pathway_Homo sapiens_hsa040150.49627403
129Wnt signaling pathway_Homo sapiens_hsa043100.48974754
130Folate biosynthesis_Homo sapiens_hsa007900.48879532
131Vitamin B6 metabolism_Homo sapiens_hsa007500.47613656
132Ether lipid metabolism_Homo sapiens_hsa005650.47178473
133Rheumatoid arthritis_Homo sapiens_hsa053230.47154678
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46634142
135Type II diabetes mellitus_Homo sapiens_hsa049300.46615304
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46144808
137Insulin signaling pathway_Homo sapiens_hsa049100.44915219
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44704993
139Metabolic pathways_Homo sapiens_hsa011000.44431023
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42717996
141Arginine and proline metabolism_Homo sapiens_hsa003300.42618752
142Regulation of autophagy_Homo sapiens_hsa041400.42155728
143Phagosome_Homo sapiens_hsa041450.40416746
144Fatty acid elongation_Homo sapiens_hsa000620.40254410
145Hedgehog signaling pathway_Homo sapiens_hsa043400.38966653
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37297063
147Chemical carcinogenesis_Homo sapiens_hsa052040.35452832
148Glutathione metabolism_Homo sapiens_hsa004800.34120893
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.33034896
150Circadian rhythm_Homo sapiens_hsa047100.32146901
151Inositol phosphate metabolism_Homo sapiens_hsa005620.31797612
152Thyroid cancer_Homo sapiens_hsa052160.31102049
153Endometrial cancer_Homo sapiens_hsa052130.31077710
154Dilated cardiomyopathy_Homo sapiens_hsa054140.30950981
155Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30309972
156Steroid biosynthesis_Homo sapiens_hsa001000.30139149
157Prion diseases_Homo sapiens_hsa050200.29309732
158Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28866108
159Endocytosis_Homo sapiens_hsa041440.28413933
160Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28327057
161Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28099518
162Bile secretion_Homo sapiens_hsa049760.27230475
163Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25624254

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