LIX1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.40046948
2collagen fibril organization (GO:0030199)4.87346280
3chondrocyte proliferation (GO:0035988)4.82606068
4behavioral response to nicotine (GO:0035095)4.60693538
5bone trabecula formation (GO:0060346)4.43651067
6axon extension involved in axon guidance (GO:0048846)4.41441029
7neuron projection extension involved in neuron projection guidance (GO:1902284)4.41441029
8sequestering of extracellular ligand from receptor (GO:0035581)4.32774551
9planar cell polarity pathway involved in neural tube closure (GO:0090179)3.96430131
10metanephric mesenchyme development (GO:0072075)3.93255603
11mesenchymal-epithelial cell signaling (GO:0060638)3.91586689
12negative regulation of catenin import into nucleus (GO:0035414)3.87053077
13regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.76897995
14kidney mesenchyme development (GO:0072074)3.72465396
15platelet dense granule organization (GO:0060155)3.65412683
16hippo signaling (GO:0035329)3.64020853
17plasma membrane repair (GO:0001778)3.53538838
18insulin-like growth factor receptor signaling pathway (GO:0048009)3.50342830
19paraxial mesoderm development (GO:0048339)3.45820156
20dermatan sulfate biosynthetic process (GO:0030208)3.43191121
21endodermal cell differentiation (GO:0035987)3.40373707
22outer ear morphogenesis (GO:0042473)3.39860129
23tyrosine phosphorylation of STAT protein (GO:0007260)3.34517211
24collagen metabolic process (GO:0032963)3.32190556
25collagen catabolic process (GO:0030574)3.26900758
26response to pheromone (GO:0019236)3.26632456
27negative regulation of telomere maintenance (GO:0032205)3.26555197
28negative regulation of chondrocyte differentiation (GO:0032331)3.23666652
29chondrocyte development (GO:0002063)3.23661441
30fucose catabolic process (GO:0019317)3.23526896
31L-fucose metabolic process (GO:0042354)3.23526896
32L-fucose catabolic process (GO:0042355)3.23526896
33pyrimidine nucleobase catabolic process (GO:0006208)3.19282242
34multicellular organismal macromolecule metabolic process (GO:0044259)3.15867714
35negative regulation of fatty acid transport (GO:2000192)3.15471953
36negative regulation of axon guidance (GO:1902668)3.14295687
37glomerular basement membrane development (GO:0032836)3.10927726
38dermatan sulfate metabolic process (GO:0030205)3.10492714
39cardiac myofibril assembly (GO:0055003)3.10005475
40negative regulation of mast cell activation (GO:0033004)3.09105018
41activated T cell proliferation (GO:0050798)3.05767262
42retina vasculature morphogenesis in camera-type eye (GO:0061299)3.05030358
43regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.04133931
44behavioral response to ethanol (GO:0048149)3.02433886
45craniofacial suture morphogenesis (GO:0097094)3.02095900
46vascular endothelial growth factor signaling pathway (GO:0038084)3.00589910
47endoderm formation (GO:0001706)3.00581902
48multicellular organismal catabolic process (GO:0044243)2.96277814
49multicellular organismal metabolic process (GO:0044236)2.96173867
50blood vessel maturation (GO:0001955)2.91976200
51head development (GO:0060322)2.90825865
52positive regulation of mesenchymal cell proliferation (GO:0002053)2.89822023
53basement membrane organization (GO:0071711)2.89112340
54neural tube formation (GO:0001841)2.89098764
55postsynaptic membrane organization (GO:0001941)2.88518789
56negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88032371
57embryonic cranial skeleton morphogenesis (GO:0048701)2.87957981
58response to gravity (GO:0009629)2.86641349
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86158995
60camera-type eye morphogenesis (GO:0048593)2.86145630
61pericardium development (GO:0060039)2.85310985
62DNA deamination (GO:0045006)2.84634513
63interkinetic nuclear migration (GO:0022027)2.84519370
64middle ear morphogenesis (GO:0042474)2.82445518
65glomerular filtration (GO:0003094)2.81841997
66nonmotile primary cilium assembly (GO:0035058)2.81630933
67positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.81071181
68regulation of mesenchymal cell proliferation (GO:0010464)2.80531213
69regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.80283692
70G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.79953875
71kidney morphogenesis (GO:0060993)2.79556180
72regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.77605837
73extracellular matrix disassembly (GO:0022617)2.77152128
74negative regulation of embryonic development (GO:0045992)2.76911817
75cell adhesion mediated by integrin (GO:0033627)2.76102728
76Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.75950673
77positive regulation of natural killer cell differentiation (GO:0032825)2.75588409
78extracellular fibril organization (GO:0043206)2.74914720
79cell proliferation involved in metanephros development (GO:0072203)2.74658335
80negative regulation of cartilage development (GO:0061037)2.74392749
81regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.74302068
82cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.73987147
83gastrulation with mouth forming second (GO:0001702)2.73983143
84protein localization to cell surface (GO:0034394)2.73359105
85regulation of axon extension involved in axon guidance (GO:0048841)2.69758950
86regulation of establishment of planar polarity (GO:0090175)2.69299784
87synaptic transmission, cholinergic (GO:0007271)2.68549711
88cell migration involved in sprouting angiogenesis (GO:0002042)2.68204493
89polarized epithelial cell differentiation (GO:0030859)2.68068423
90trabecula formation (GO:0060343)2.67574895
91endothelial cell morphogenesis (GO:0001886)2.67489004
92renal filtration (GO:0097205)2.65927113
93parental behavior (GO:0060746)2.64455807
94regulation of heart morphogenesis (GO:2000826)2.64340652
95stress fiber assembly (GO:0043149)2.64018128
96retinal ganglion cell axon guidance (GO:0031290)2.63650945
97nucleobase catabolic process (GO:0046113)2.62363031
98lymphangiogenesis (GO:0001946)2.62222725
99skin morphogenesis (GO:0043589)2.62134328
100mesenchyme development (GO:0060485)2.61493885
101cAMP catabolic process (GO:0006198)2.61348448
102positive regulation of defense response to virus by host (GO:0002230)2.60819401
103convergent extension (GO:0060026)2.59517271
104renal tubule morphogenesis (GO:0061333)2.59321134
105atrial septum morphogenesis (GO:0060413)2.58498966
106positive regulation of epithelial to mesenchymal transition (GO:0010718)2.58290400
107cell migration involved in heart development (GO:0060973)2.57358188
108neuron fate determination (GO:0048664)2.57303421
109endocardial cushion development (GO:0003197)2.57243521
110regulation of catenin import into nucleus (GO:0035412)2.57132686
111glial cell migration (GO:0008347)2.56040181
112axon extension (GO:0048675)2.54676345
113ovulation cycle (GO:0042698)2.54354754
114preassembly of GPI anchor in ER membrane (GO:0016254)2.53147707
115semaphorin-plexin signaling pathway (GO:0071526)2.52583342
116positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.52311841
117ganglion development (GO:0061548)2.52199541
118artery development (GO:0060840)2.51917861
119epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.51156608
120cochlea morphogenesis (GO:0090103)2.50939404
121positive regulation of glycogen biosynthetic process (GO:0045725)2.50493173
122regulation of respiratory system process (GO:0044065)2.50213474
123regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.50164707
124positive regulation of gastrulation (GO:2000543)2.49406362
125regulation of telomere maintenance (GO:0032204)2.48379262
126dendritic spine morphogenesis (GO:0060997)2.48318893
127eye morphogenesis (GO:0048592)2.48176261
128regulation of axon guidance (GO:1902667)2.47492170
129non-canonical Wnt signaling pathway (GO:0035567)2.47242453
130gonadal mesoderm development (GO:0007506)2.46615749
131presynaptic membrane organization (GO:0097090)2.46336713
132heart morphogenesis (GO:0003007)2.46030469
133body morphogenesis (GO:0010171)2.45811017
134cellular response to vitamin (GO:0071295)2.45121320
135regulation of type B pancreatic cell apoptotic process (GO:2000674)2.44048026
136macroautophagy (GO:0016236)2.43877216
137inositol phosphate catabolic process (GO:0071545)2.43199572
138negative regulation of axon extension involved in axon guidance (GO:0048843)2.43042179
139substrate-dependent cell migration (GO:0006929)2.42933969
140regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.41412824
141radial glial cell differentiation (GO:0060019)2.40551554
142protein hydroxylation (GO:0018126)2.40453061
143extracellular matrix assembly (GO:0085029)2.39948262
144lateral sprouting from an epithelium (GO:0060601)2.39626522
145regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.39291330
146extracellular regulation of signal transduction (GO:1900115)2.38324136
147extracellular negative regulation of signal transduction (GO:1900116)2.38324136
148organ induction (GO:0001759)2.37614537
149tongue development (GO:0043586)2.37267241
150nephron tubule morphogenesis (GO:0072078)2.37048093
151nephron epithelium morphogenesis (GO:0072088)2.37048093
152regulation of cartilage development (GO:0061035)2.36423213
153cyclic nucleotide catabolic process (GO:0009214)2.35772564
154detection of light stimulus involved in visual perception (GO:0050908)2.35679851
155detection of light stimulus involved in sensory perception (GO:0050962)2.35679851
156presynaptic membrane assembly (GO:0097105)2.35418343
157cilium morphogenesis (GO:0060271)2.33003824
158protein polyglutamylation (GO:0018095)2.32969934
159somite development (GO:0061053)2.29952780
160transmission of nerve impulse (GO:0019226)2.29853312
161regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.29708316
162dentate gyrus development (GO:0021542)2.28032909
163maternal behavior (GO:0042711)2.25051638
164endosome to melanosome transport (GO:0035646)2.24696771
165endosome to pigment granule transport (GO:0043485)2.24696771
166detection of mechanical stimulus involved in sensory perception (GO:0050974)2.24280727
167regulation of glucokinase activity (GO:0033131)2.23816056
168regulation of hexokinase activity (GO:1903299)2.23816056
169nucleus localization (GO:0051647)2.22730196
170cornea development in camera-type eye (GO:0061303)2.22690804
171regulation of neurotransmitter uptake (GO:0051580)2.20951062
172venous blood vessel morphogenesis (GO:0048845)2.20337148
173negative regulation of axon extension (GO:0030517)2.19517903
174interferon-gamma production (GO:0032609)2.19452915
175startle response (GO:0001964)2.18724730
176spinal cord development (GO:0021510)2.18558330
177type B pancreatic cell development (GO:0003323)2.18450116
178negative regulation of cAMP-mediated signaling (GO:0043951)2.17892693
179glycerophospholipid catabolic process (GO:0046475)2.17642951
180negative regulation of execution phase of apoptosis (GO:1900118)2.16210437
181axonal fasciculation (GO:0007413)2.14698554
182smoothened signaling pathway (GO:0007224)2.13612355
183cellular ketone body metabolic process (GO:0046950)2.12875976
184negative regulation of chemotaxis (GO:0050922)2.12768600
185neuronal stem cell maintenance (GO:0097150)2.12449016
186positive regulation of cardiac muscle cell differentiation (GO:2000727)2.12159272
187regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.11189638
188negative regulation of nitric-oxide synthase activity (GO:0051001)2.10813055
189cellular response to interleukin-15 (GO:0071350)2.10055433
190epithelial cilium movement (GO:0003351)2.09853613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.56430040
2RARG_19884340_ChIP-ChIP_MEFs_Mouse2.82531958
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82368435
4EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.63144035
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.49870817
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44775606
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44775606
8EZH2_22144423_ChIP-Seq_EOC_Human2.41744598
9WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.38064489
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.33865338
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31842656
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.26335195
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25692524
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24196955
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.23398225
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.22429423
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.21507893
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18439606
19EP300_21415370_ChIP-Seq_HL-1_Mouse2.17057303
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15441715
21VDR_22108803_ChIP-Seq_LS180_Human2.10700106
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10514048
23CLOCK_20551151_ChIP-Seq_293T_Human2.10447167
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09968052
25JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03359891
26STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00634791
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99008674
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.98137775
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.96417420
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96386887
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96010506
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94969469
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93057674
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89699723
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.86569269
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86229319
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.85598531
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84582955
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84325024
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.82053481
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80815925
42P300_19829295_ChIP-Seq_ESCs_Human1.76048426
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75811433
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74818260
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.74761733
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73510464
47FUS_26573619_Chip-Seq_HEK293_Human1.73469248
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72834285
49CJUN_26792858_Chip-Seq_BT549_Human1.72572719
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.72174721
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69787543
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66570311
53BRD4_25478319_ChIP-Seq_HGPS_Human1.66052116
54TAF15_26573619_Chip-Seq_HEK293_Human1.63964677
55SMAD4_21799915_ChIP-Seq_A2780_Human1.63519334
56EWS_26573619_Chip-Seq_HEK293_Human1.63416114
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63189267
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62963804
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62322842
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60542419
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59428026
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.58852029
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58201172
64* ER_23166858_ChIP-Seq_MCF-7_Human1.51865106
65BCAT_22108803_ChIP-Seq_LS180_Human1.51740769
66STAT3_23295773_ChIP-Seq_U87_Human1.51291071
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.51116863
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50703335
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.48712525
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47374981
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46518171
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46499113
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45282405
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.45146528
75TP53_18474530_ChIP-ChIP_U2OS_Human1.43810341
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42458131
77IGF1R_20145208_ChIP-Seq_DFB_Human1.41517315
78AR_25329375_ChIP-Seq_VCAP_Human1.41474031
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41380140
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40267236
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40087312
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40067813
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39580007
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39580007
85AR_21572438_ChIP-Seq_LNCaP_Human1.38619092
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38097034
87TP53_16413492_ChIP-PET_HCT116_Human1.36581252
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.36190563
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34163696
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33978591
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.33772082
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.33433416
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.33290240
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.33188189
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33045916
96RNF2_27304074_Chip-Seq_NSC_Mouse1.30399598
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29635154
98CBP_20019798_ChIP-Seq_JUKART_Human1.29532547
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29532547
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29286421
101SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27177166
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26985307
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26549158
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26111216
105* KDM2B_26808549_Chip-Seq_K562_Human1.25176839
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25159430
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24909779
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24554666
109TCF4_23295773_ChIP-Seq_U87_Human1.24450883
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.24380100
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.24293202
112* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24185432
113* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23490470
114P53_22387025_ChIP-Seq_ESCs_Mouse1.23011386
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.22593612
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22552313
117DROSHA_22980978_ChIP-Seq_HELA_Human1.22072152
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.21148231
119GBX2_23144817_ChIP-Seq_PC3_Human1.21048802
120RUNX_20019798_ChIP-Seq_JUKART_Human1.20707026
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19879285
122TBX20_22328084_ChIP-Seq_HEART_Mouse1.19858913
123TBX20_22080862_ChIP-Seq_HEART_Mouse1.19858913
124HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19723321
125SALL1_21062744_ChIP-ChIP_HESCs_Human1.19440740
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.17834485
127MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17564521
128BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17234263
129ZNF274_21170338_ChIP-Seq_K562_Hela1.17175379
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16846855
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13803066
132EGR1_19374776_ChIP-ChIP_THP-1_Human1.13644210
133NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13466910
134SOX2_19829295_ChIP-Seq_ESCs_Human1.12791215
135NANOG_19829295_ChIP-Seq_ESCs_Human1.12791215
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12697047
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12697047
138SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10358654
139KDM2B_26808549_Chip-Seq_REH_Human1.10230120
140EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08193959
141SOX2_21211035_ChIP-Seq_LN229_Gbm1.08042372
142CRX_20693478_ChIP-Seq_RETINA_Mouse1.07537869
143SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07295825
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06257610
145AHR_22903824_ChIP-Seq_MCF-7_Human1.06175751
146* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06031785
147ARNT_22903824_ChIP-Seq_MCF-7_Human1.05298178
148SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04709396
149E2F1_18555785_Chip-Seq_ESCs_Mouse1.04644104
150CMYC_18555785_Chip-Seq_ESCs_Mouse1.04240225
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04112898
152EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03165094
153TCF4_18268006_ChIP-ChIP_LS174T_Human1.02591531
154* KDM2B_26808549_Chip-Seq_JURKAT_Human1.01498283
155SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00339352
156PIAS1_25552417_ChIP-Seq_VCAP_Human0.99696915
157TP53_23651856_ChIP-Seq_MEFs_Mouse0.99393363
158UBF1/2_26484160_Chip-Seq_HMECs_Human0.97355688
159OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97340038
160PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97257837
161UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97185971
162NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93006579
163ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92339628
164BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92297305
165ELK3_25401928_ChIP-Seq_HUVEC_Human0.90208627
166ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90201405
167CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89893311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.38844323
2MP0005503_abnormal_tendon_morphology4.73199323
3MP0005275_abnormal_skin_tensile3.81925886
4MP0003705_abnormal_hypodermis_morpholog3.19104353
5MP0004272_abnormal_basement_membrane2.86124659
6MP0005623_abnormal_meninges_morphology2.79486300
7MP0003279_aneurysm2.67871266
8MP0001958_emphysema2.50833288
9MP0010030_abnormal_orbit_morphology2.32150271
10MP0000372_irregular_coat_pigmentation2.28452939
11MP0003385_abnormal_body_wall2.20436371
12MP0005257_abnormal_intraocular_pressure2.17936009
13MP0004142_abnormal_muscle_tone2.06955491
14MP0002102_abnormal_ear_morphology2.06622387
15MP0009250_abnormal_appendicular_skeleto2.03995744
16MP0005508_abnormal_skeleton_morphology2.02670013
17MP0009384_cardiac_valve_regurgitation1.96057051
18MP0005084_abnormal_gallbladder_morpholo1.88727823
19MP0002638_abnormal_pupillary_reflex1.88169999
20MP0006054_spinal_hemorrhage1.87104056
21MP0004885_abnormal_endolymph1.85303034
22MP0000751_myopathy1.84678620
23MP0002108_abnormal_muscle_morphology1.75543129
24MP0000733_abnormal_muscle_development1.74872913
25MP0000537_abnormal_urethra_morphology1.74325203
26MP0003942_abnormal_urinary_system1.71811899
27MP0002928_abnormal_bile_duct1.70827803
28MP0001299_abnormal_eye_distance/1.66296853
29MP0000428_abnormal_craniofacial_morphol1.63717148
30MP0010368_abnormal_lymphatic_system1.63644739
31MP0000049_abnormal_middle_ear1.61665384
32MP0006072_abnormal_retinal_apoptosis1.61256756
33MP0005551_abnormal_eye_electrophysiolog1.61209257
34MP0009053_abnormal_anal_canal1.60932888
35MP0000534_abnormal_ureter_morphology1.59811797
36MP0002282_abnormal_trachea_morphology1.59621397
37MP0003195_calcinosis1.57265576
38MP0002163_abnormal_gland_morphology1.55373214
39MP0002896_abnormal_bone_mineralization1.51819271
40MP0002876_abnormal_thyroid_physiology1.49666488
41MP0002249_abnormal_larynx_morphology1.49097412
42MP0003122_maternal_imprinting1.46519264
43MP0003755_abnormal_palate_morphology1.46315217
44MP0005174_abnormal_tail_pigmentation1.44455635
45MP0003115_abnormal_respiratory_system1.43147325
46MP0004084_abnormal_cardiac_muscle1.39638225
47MP0002932_abnormal_joint_morphology1.38688198
48MP0005645_abnormal_hypothalamus_physiol1.37927258
49MP0003950_abnormal_plasma_membrane1.37426965
50MP0000013_abnormal_adipose_tissue1.36646925
51MP0002127_abnormal_cardiovascular_syste1.35935757
52MP0003091_abnormal_cell_migration1.35873317
53MP0001984_abnormal_olfaction1.35658953
54MP0005171_absent_coat_pigmentation1.35282041
55MP0005253_abnormal_eye_physiology1.34346183
56MP0003935_abnormal_craniofacial_develop1.34233282
57MP0003283_abnormal_digestive_organ1.34032091
58MP0004133_heterotaxia1.29520400
59MP0004130_abnormal_muscle_cell1.29404311
60MP0004145_abnormal_muscle_electrophysio1.29115408
61MP0001879_abnormal_lymphatic_vessel1.28860319
62MP0009780_abnormal_chondrocyte_physiolo1.28170422
63MP0003937_abnormal_limbs/digits/tail_de1.27679671
64MP0000767_abnormal_smooth_muscle1.26924127
65MP0005248_abnormal_Harderian_gland1.26441654
66MP0000163_abnormal_cartilage_morphology1.25802707
67MP0005367_renal/urinary_system_phenotyp1.24824863
68MP0000516_abnormal_urinary_system1.24824863
69MP0003646_muscle_fatigue1.24335724
70MP0004134_abnormal_chest_morphology1.23081419
71MP0003566_abnormal_cell_adhesion1.22453401
72MP0000230_abnormal_systemic_arterial1.22280952
73MP0002837_dystrophic_cardiac_calcinosis1.21022474
74MP0002138_abnormal_hepatobiliary_system1.19593879
75MP0002938_white_spotting1.17993779
76MP0005076_abnormal_cell_differentiation1.17337844
77MP0002116_abnormal_craniofacial_bone1.17333608
78MP0002060_abnormal_skin_morphology1.16720294
79MP0009745_abnormal_behavioral_response1.14893928
80MP0002115_abnormal_skeleton_extremities1.14664393
81MP0004924_abnormal_behavior1.14471518
82MP0005386_behavior/neurological_phenoty1.14471518
83MP0005379_endocrine/exocrine_gland_phen1.14344882
84MP0001542_abnormal_bone_strength1.13445731
85MP0000750_abnormal_muscle_regeneration1.12237432
86MP0002933_joint_inflammation1.10816017
87MP0000762_abnormal_tongue_morphology1.10536073
88MP0008775_abnormal_heart_ventricle1.10279784
89MP0001501_abnormal_sleep_pattern1.09627471
90MP0002295_abnormal_pulmonary_circulatio1.08740875
91MP0004215_abnormal_myocardial_fiber1.06696143
92MP0000015_abnormal_ear_pigmentation1.06457358
93MP0000432_abnormal_head_morphology1.06429894
94MP0002877_abnormal_melanocyte_morpholog1.05622895
95MP0000569_abnormal_digit_pigmentation1.05619589
96MP0000685_abnormal_immune_system1.05489427
97MP0004233_abnormal_muscle_weight1.03872275
98MP0002233_abnormal_nose_morphology1.02097063
99MP0001968_abnormal_touch/_nociception1.02057349
100MP0004087_abnormal_muscle_fiber1.01035680
101MP0000003_abnormal_adipose_tissue1.00643452
102MP0003941_abnormal_skin_development1.00056749
103MP0005195_abnormal_posterior_eye0.99399726
104MP0005167_abnormal_blood-brain_barrier0.99183789
105MP0002653_abnormal_ependyma_morphology0.98881715
106MP0000427_abnormal_hair_cycle0.98568359
107MP0000631_abnormal_neuroendocrine_gland0.98323033
108MP0006138_congestive_heart_failure0.98187973
109MP0002113_abnormal_skeleton_development0.98018803
110MP0002089_abnormal_postnatal_growth/wei0.97608654
111MP0002572_abnormal_emotion/affect_behav0.97567045
112MP0002109_abnormal_limb_morphology0.97163950
113MP0009046_muscle_twitch0.96537000
114MP0002272_abnormal_nervous_system0.95471282
115MP0004085_abnormal_heartbeat0.95310802
116MP0001485_abnormal_pinna_reflex0.94432430
117MP0008961_abnormal_basal_metabolism0.92078467
118MP0005646_abnormal_pituitary_gland0.91968323
119MP0001970_abnormal_pain_threshold0.91033187
120MP0002557_abnormal_social/conspecific_i0.90905189
121MP0003137_abnormal_impulse_conducting0.89145744
122MP0000759_abnormal_skeletal_muscle0.88637529
123MP0003045_fibrosis0.87352470
124MP0002128_abnormal_blood_circulation0.87050786
125MP0005187_abnormal_penis_morphology0.86932374
126MP0006276_abnormal_autonomic_nervous0.86863376
127MP0002114_abnormal_axial_skeleton0.85895251
128MP0010630_abnormal_cardiac_muscle0.84901306
129MP0001324_abnormal_eye_pigmentation0.84748429
130MP0002177_abnormal_outer_ear0.84462546
131MP0002067_abnormal_sensory_capabilities0.84156719
132MP0004858_abnormal_nervous_system0.83739688
133MP0005023_abnormal_wound_healing0.83716685
134MP0002095_abnormal_skin_pigmentation0.83716634
135MP0010352_gastrointestinal_tract_polyps0.83116273
136MP0002925_abnormal_cardiovascular_devel0.82990923
137MP0002697_abnormal_eye_size0.82960273
138MP0002234_abnormal_pharynx_morphology0.81896956
139MP0001944_abnormal_pancreas_morphology0.81758888
140MP0005390_skeleton_phenotype0.81698933
141MP0003567_abnormal_fetal_cardiomyocyte0.81601341
142MP0005369_muscle_phenotype0.81339098
143MP0004484_altered_response_of0.80940294
144MP0000613_abnormal_salivary_gland0.80921022
145MP0002184_abnormal_innervation0.79611829
146MP0003136_yellow_coat_color0.78853912
147MP0002733_abnormal_thermal_nociception0.78654590
148MP0002972_abnormal_cardiac_muscle0.77957221
149MP0001502_abnormal_circadian_rhythm0.77568857
150MP0001614_abnormal_blood_vessel0.76513333
151MP0002111_abnormal_tail_morphology0.75828582
152MP0002693_abnormal_pancreas_physiology0.75507957
153MP0003828_pulmonary_edema0.75427190
154MP0005595_abnormal_vascular_smooth0.74638398
155MP0004043_abnormal_pH_regulation0.74079857
156MP0001270_distended_abdomen0.74004341
157MP0000778_abnormal_nervous_system0.73678240
158MP0002168_other_aberrant_phenotype0.72852817
159MP0000749_muscle_degeneration0.72467631
160MP0003763_abnormal_thymus_physiology0.72325021
161MP0001544_abnormal_cardiovascular_syste0.72283034
162MP0005385_cardiovascular_system_phenoty0.72283034
163MP0005375_adipose_tissue_phenotype0.72253735
164MP0005197_abnormal_uvea_morphology0.72038399
165MP0005620_abnormal_muscle_contractility0.72027931
166MP0003880_abnormal_central_pattern0.71880170
167MP0003252_abnormal_bile_duct0.71493664
168MP0010386_abnormal_urinary_bladder0.70874084
169MP0004036_abnormal_muscle_relaxation0.69391518

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.42564757
2Premature rupture of membranes (HP:0001788)5.99044172
3Shallow orbits (HP:0000586)4.77682717
4Abnormality of midbrain morphology (HP:0002418)4.42356901
5Molar tooth sign on MRI (HP:0002419)4.42356901
6Broad metatarsal (HP:0001783)4.35737066
7Ankle contracture (HP:0006466)4.26595022
8Aortic dissection (HP:0002647)3.85844394
9Bladder diverticulum (HP:0000015)3.78978129
10Pancreatic cysts (HP:0001737)3.70047907
11Nephronophthisis (HP:0000090)3.65236432
12Soft skin (HP:0000977)3.54409848
13Cerebral aneurysm (HP:0004944)3.40324884
14Large for gestational age (HP:0001520)3.39132207
15Pancreatic fibrosis (HP:0100732)3.27290058
16Atrophic scars (HP:0001075)3.26761839
17Short 4th metacarpal (HP:0010044)3.20296260
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.20296260
19Abnormality of the renal medulla (HP:0100957)3.14613323
20Abnormality of dentin (HP:0010299)3.13550894
21Abnormality of the renal cortex (HP:0011035)3.12478495
22Neonatal short-limb short stature (HP:0008921)3.11514043
23Congenital stationary night blindness (HP:0007642)3.11381696
24True hermaphroditism (HP:0010459)3.10824799
25Aortic aneurysm (HP:0004942)3.10369492
26Type 1 muscle fiber predominance (HP:0003803)3.06538220
27Follicular hyperkeratosis (HP:0007502)3.01020856
28Keratoconus (HP:0000563)2.97995600
29Increased corneal curvature (HP:0100692)2.97995600
30Dilatation of the ascending aorta (HP:0005111)2.97778193
31Hemiparesis (HP:0001269)2.95383001
32Mitral valve prolapse (HP:0001634)2.94234283
33Wrist flexion contracture (HP:0001239)2.89272418
34Spinal rigidity (HP:0003306)2.88191401
35Genu recurvatum (HP:0002816)2.87093534
36Fragile skin (HP:0001030)2.84176171
37Abnormality of the 4th metacarpal (HP:0010012)2.84099647
38Medial flaring of the eyebrow (HP:0010747)2.82747602
39Cervical subluxation (HP:0003308)2.79726519
40Chronic hepatic failure (HP:0100626)2.77289962
41Renal cortical cysts (HP:0000803)2.70104566
42Bowel diverticulosis (HP:0005222)2.69759740
43Asymmetry of the thorax (HP:0001555)2.66428295
44Peritonitis (HP:0002586)2.64515228
45Type II lissencephaly (HP:0007260)2.64201270
46Prominent supraorbital ridges (HP:0000336)2.64060971
47Coronal craniosynostosis (HP:0004440)2.61318098
48Blue sclerae (HP:0000592)2.61014546
49Deviation of the hallux (HP:0010051)2.60779449
50Overgrowth (HP:0001548)2.59631537
51Hyperextensible skin (HP:0000974)2.58055322
52Papilledema (HP:0001085)2.57155421
53Buphthalmos (HP:0000557)2.56326070
54Lissencephaly (HP:0001339)2.55406192
55Hyperventilation (HP:0002883)2.52744953
56Wormian bones (HP:0002645)2.50315884
57Arthropathy (HP:0003040)2.48783275
58Increased connective tissue (HP:0009025)2.48707298
59Renal duplication (HP:0000075)2.47644751
60Wide anterior fontanel (HP:0000260)2.47245353
61Hallux valgus (HP:0001822)2.45111931
62Mildly elevated creatine phosphokinase (HP:0008180)2.41569615
63Attenuation of retinal blood vessels (HP:0007843)2.41417138
64Increased variability in muscle fiber diameter (HP:0003557)2.39477984
65Thyroiditis (HP:0100646)2.38384916
66Congenital, generalized hypertrichosis (HP:0004540)2.35544057
67Tubular atrophy (HP:0000092)2.32754357
68Abnormal drinking behavior (HP:0030082)2.32268798
69Polydipsia (HP:0001959)2.32268798
70Bell-shaped thorax (HP:0001591)2.31364670
71Mesomelia (HP:0003027)2.28102440
72Joint laxity (HP:0001388)2.25451171
73Flat cornea (HP:0007720)2.23160397
74Morphological abnormality of the middle ear (HP:0008609)2.21459108
75Lymphangioma (HP:0100764)2.21330526
76Gait imbalance (HP:0002141)2.21132758
77Elevated erythrocyte sedimentation rate (HP:0003565)2.19733817
78Pachygyria (HP:0001302)2.16925826
79Enlarged penis (HP:0000040)2.16720506
80Delayed gross motor development (HP:0002194)2.16615559
81Bulbous nose (HP:0000414)2.15873113
82Hematochezia (HP:0002573)2.13015998
83Metaphyseal dysplasia (HP:0100255)2.11678107
84Inability to walk (HP:0002540)2.11510126
85Slender build (HP:0001533)2.10858451
86Biconcave vertebral bodies (HP:0004586)2.09887931
87Vascular tortuosity (HP:0004948)2.09872090
88Aneurysm (HP:0002617)2.08797611
89Albinism (HP:0001022)2.07737473
90Syringomyelia (HP:0003396)2.07473192
91Spinal cord lesions (HP:0100561)2.07473192
92Absent speech (HP:0001344)2.06170563
93Protruding tongue (HP:0010808)2.05615076
94Congenital hepatic fibrosis (HP:0002612)2.05348833
95Broad long bones (HP:0005622)2.05191042
96Abnormal rod and cone electroretinograms (HP:0008323)2.04791704
97Broad ribs (HP:0000885)2.04516909
98Hyperacusis (HP:0010780)2.04128300
99Congenital primary aphakia (HP:0007707)2.04021091
100Subacute progressive viral hepatitis (HP:0006572)2.03110812
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03099393
102Abnormality of alanine metabolism (HP:0010916)2.03099393
103Hyperalaninemia (HP:0003348)2.03099393
104Broad-based gait (HP:0002136)2.01576006
105Renovascular hypertension (HP:0100817)2.01244315
106Elbow flexion contracture (HP:0002987)2.00749506
107Hypoplastic iliac wings (HP:0002866)2.00498761
108Abnormality of skeletal muscle fiber size (HP:0012084)2.00057719
109Nephrogenic diabetes insipidus (HP:0009806)1.99758834
110Left ventricular hypertrophy (HP:0001712)1.97264677
111Aplasia/Hypoplasia of the fovea (HP:0008060)1.96834625
112Hypoplasia of the fovea (HP:0007750)1.96834625
113Exostoses (HP:0100777)1.96671124
114Camptodactyly of toe (HP:0001836)1.96385759
115Infantile muscular hypotonia (HP:0008947)1.95374096
116Atrial fibrillation (HP:0005110)1.95125567
117Scapular winging (HP:0003691)1.94312057
118Mitral regurgitation (HP:0001653)1.94039560
119Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93361458
120Congenital glaucoma (HP:0001087)1.93120787
121Prolonged QT interval (HP:0001657)1.92357801
122Fair hair (HP:0002286)1.92312840
123Bronchomalacia (HP:0002780)1.91058220
124Venous abnormality (HP:0002624)1.90808061
125Turricephaly (HP:0000262)1.89696243
126Hypoplastic ischia (HP:0003175)1.89587541
127Vertebral compression fractures (HP:0002953)1.89445372
128Palpebral edema (HP:0100540)1.88851049
129Anterior segment dysgenesis (HP:0007700)1.88474322
130Furrowed tongue (HP:0000221)1.87122853
131Thin bony cortex (HP:0002753)1.86954776
132Protruding ear (HP:0000411)1.86951528
133Venous insufficiency (HP:0005293)1.86576605
134Genetic anticipation (HP:0003743)1.85797272
135Polyuria (HP:0000103)1.84693557
136Cystic liver disease (HP:0006706)1.83859322
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.83623364
138Primary atrial arrhythmia (HP:0001692)1.82953136
139Arterial tortuosity (HP:0005116)1.82257576
140Hypoventilation (HP:0002791)1.81981780
141Exotropia (HP:0000577)1.81716475
142Aplasia/Hypoplasia of the spleen (HP:0010451)1.81642313
143Severe combined immunodeficiency (HP:0004430)1.79514080
144Chorioretinal atrophy (HP:0000533)1.78965037
145Progressive inability to walk (HP:0002505)1.76754536
146Narrow nasal bridge (HP:0000446)1.76461969
147Intestinal atresia (HP:0011100)1.76237193
148Narrow forehead (HP:0000341)1.75751836
149Progressive cerebellar ataxia (HP:0002073)1.74755662
150Abnormal delivery (HP:0001787)1.74572314
151Aplasia involving bones of the extremities (HP:0009825)1.74380116
152Aplasia involving bones of the upper limbs (HP:0009823)1.74380116
153Aplasia of the phalanges of the hand (HP:0009802)1.74380116
154Hamartoma of the eye (HP:0010568)1.73620978
155Broad phalanx (HP:0006009)1.73618365
156Short foot (HP:0001773)1.73334939
157Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72911109
158Pheochromocytoma (HP:0002666)1.72289820
159Supraventricular tachycardia (HP:0004755)1.72049606
160Disproportionate short-trunk short stature (HP:0003521)1.71824068
161Supraventricular arrhythmia (HP:0005115)1.71402836
162Asplenia (HP:0001746)1.70116887
163Hypoproteinemia (HP:0003075)1.69750568
164Tarsal synostosis (HP:0008368)1.69744071
165Sclerocornea (HP:0000647)1.69524426
166Osteopenia (HP:0000938)1.69047725
167Hip contracture (HP:0003273)1.68838372
168Stomatitis (HP:0010280)1.68622596
169Postaxial foot polydactyly (HP:0001830)1.67979038
170Broad toe (HP:0001837)1.67626033
171Knee flexion contracture (HP:0006380)1.67465801
172Striae distensae (HP:0001065)1.67251488
173Large eyes (HP:0001090)1.66664080
174Congenital sensorineural hearing impairment (HP:0008527)1.66548458
175Adactyly (HP:0009776)1.66435340
176Limb-girdle muscle weakness (HP:0003325)1.66267635
177Elfin facies (HP:0004428)1.66261386
178Abnormality of the ischium (HP:0003174)1.65526770
179Tibial bowing (HP:0002982)1.65459233
180Neuroendocrine neoplasm (HP:0100634)1.65211764
181Methylmalonic acidemia (HP:0002912)1.65062689
182Osteoarthritis (HP:0002758)1.64981018
183Severe muscular hypotonia (HP:0006829)1.64895997
184Inguinal hernia (HP:0000023)1.64457661
185Midline defect of the nose (HP:0004122)1.64278909
186Disproportionate tall stature (HP:0001519)1.63745381
187Rectal prolapse (HP:0002035)1.63311352
188Abolished electroretinogram (ERG) (HP:0000550)1.62931401
189Arnold-Chiari malformation (HP:0002308)1.62664159
190Hypothermia (HP:0002045)1.61990444
191Retinal dysplasia (HP:0007973)1.61639192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.52119878
2DDR24.38430944
3PDGFRA3.54082772
4LATS13.43511304
5TTN3.40153276
6PKN23.37616264
7PINK13.07488243
8EPHB23.03588610
9LATS22.85119245
10BMPR1B2.70653102
11CAMKK22.48047690
12WNK42.30520728
13PNCK2.24451508
14RIPK12.22512950
15SIK12.16380677
16ADRBK22.14230577
17DMPK2.00558472
18EPHA31.89077034
19CASK1.83993805
20WNK31.76121420
21FER1.64885700
22BMX1.62244318
23PRKD31.58710308
24MAP4K21.56237994
25PAK21.55264394
26PTK61.54649583
27MARK11.52932847
28INSRR1.49416678
29TNIK1.44177617
30TXK1.41719154
31ILK1.41459643
32SIK31.32018379
33FGFR11.31295772
34PAK31.29511184
35GRK11.28950912
36PDGFRB1.26973395
37TRIM281.25125123
38ACVR1B1.23090444
39NLK1.22470097
40STK31.21989855
41ERBB31.21877781
42FGFR21.21060554
43PTK21.18540452
44CAMK1G1.18041737
45TLK11.15740833
46ROCK11.15692778
47LMTK21.15116818
48MAP2K61.10598143
49PIK3CA1.09869559
50PAK41.09024253
51CAMK1D1.08420735
52TAOK31.08031247
53GRK71.07978729
54PHKG21.07775535
55PHKG11.07775535
56PAK61.04738268
57MAP3K101.03733881
58AKT31.01347997
59PTK2B1.00996416
60DAPK20.98987927
61CDC42BPA0.96075563
62PLK20.95192666
63EEF2K0.93159145
64MTOR0.91972158
65ICK0.91386013
66TGFBR20.91118504
67LIMK10.90543794
68MKNK20.90425097
69FRK0.89817885
70TGFBR10.89108165
71RET0.85950236
72PRKD20.84900890
73KIT0.84393650
74TYRO30.81984969
75PRKCQ0.81401423
76DYRK1B0.80324117
77MKNK10.79783015
78CAMKK10.79168495
79MET0.79103642
80KSR10.78922589
81ROCK20.78308323
82STK380.78188269
83NEK90.77598121
84MYLK0.77059125
85STK390.76517055
86OBSCN0.74321475
87STK38L0.73504867
88PRKCG0.73167686
89PRKD10.73024621
90ITK0.71114639
91LRRK20.70617633
92CDK60.69462706
93TYK20.68602506
94PRKCH0.68434425
95WNK10.66802333
96MAP3K60.65503417
97NTRK10.65118419
98ERBB20.64269984
99FLT30.61780934
100FGFR30.59224417
101TEC0.58402700
102BCKDK0.56576493
103CSNK1G20.56478540
104MAP3K70.55964175
105TIE10.54709890
106MAP3K40.53717911
107CAMK10.53385727
108STK100.52147467
109FES0.51285389
110MAP2K70.50350192
111MOS0.50231902
112WEE10.49454888
113NUAK10.49451558
114JAK10.49299532
115SGK20.48529222
116PRKCE0.48347124
117PIK3CG0.47101417
118SYK0.46959384
119HIPK20.46595608
120STK110.44466712
121INSR0.44433647
122MARK30.43912436
123NTRK30.43803664
124BCR0.43719912
125CAMK2A0.42714586
126MAPK70.42379222
127HCK0.42188505
128RPS6KA20.41639398
129ADRBK10.41382181
130NEK20.40883937
131LCK0.40674053
132YES10.40106195
133SRC0.39678562
134CAMK40.38605436
135PRKG10.38257701
136TRPM70.37491996
137MAP2K10.36432308
138CDK140.35964563
139GSK3A0.35747177
140ALK0.32520082
141RPS6KA40.31772171
142CDK120.30831266
143CSNK1A1L0.29969935
144ERN10.29638849
145MAPK130.28491094
146DYRK20.28313295
147ABL20.27803316
148CDK150.27362740
149TESK10.26224022
150DAPK30.26173663
151NTRK20.25729182
152MARK20.25138281
153IGF1R0.24563180
154AKT10.23950359
155MAPK90.23890675
156CDK180.23445693
157SIK20.23056407

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.07249537
2Focal adhesion_Homo sapiens_hsa045102.57601625
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43045371
4Dilated cardiomyopathy_Homo sapiens_hsa054142.28338017
5Protein export_Homo sapiens_hsa030602.25652090
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.16011489
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.12051339
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.11210868
9Basal cell carcinoma_Homo sapiens_hsa052172.06230799
10Proteoglycans in cancer_Homo sapiens_hsa052052.05791152
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97573017
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.88033042
13Adherens junction_Homo sapiens_hsa045201.86747167
14Hippo signaling pathway_Homo sapiens_hsa043901.84054516
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82328002
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.79125937
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77186819
18Phototransduction_Homo sapiens_hsa047441.75145416
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.74794942
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.74136813
21Axon guidance_Homo sapiens_hsa043601.72329677
22Hedgehog signaling pathway_Homo sapiens_hsa043401.72325013
23Protein digestion and absorption_Homo sapiens_hsa049741.71726880
24Glioma_Homo sapiens_hsa052141.70983677
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68452848
26TGF-beta signaling pathway_Homo sapiens_hsa043501.67762282
27Melanoma_Homo sapiens_hsa052181.66984558
28MicroRNAs in cancer_Homo sapiens_hsa052061.64336074
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63362133
30Bladder cancer_Homo sapiens_hsa052191.60141699
31Chronic myeloid leukemia_Homo sapiens_hsa052201.60120800
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.59671821
33Amoebiasis_Homo sapiens_hsa051461.56812724
34Butanoate metabolism_Homo sapiens_hsa006501.56741171
35Small cell lung cancer_Homo sapiens_hsa052221.55530887
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51319138
37Insulin secretion_Homo sapiens_hsa049111.50772770
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.50156460
39Morphine addiction_Homo sapiens_hsa050321.49476931
40Viral myocarditis_Homo sapiens_hsa054161.43644131
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41702752
42Endometrial cancer_Homo sapiens_hsa052131.41515027
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.40172546
44Wnt signaling pathway_Homo sapiens_hsa043101.39721453
45Type I diabetes mellitus_Homo sapiens_hsa049401.37977013
46Primary immunodeficiency_Homo sapiens_hsa053401.37394268
47Melanogenesis_Homo sapiens_hsa049161.36892397
48PI3K-Akt signaling pathway_Homo sapiens_hsa041511.33720296
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33457796
50Nitrogen metabolism_Homo sapiens_hsa009101.30363546
51Renal cell carcinoma_Homo sapiens_hsa052111.26360392
52Gap junction_Homo sapiens_hsa045401.25762780
53Colorectal cancer_Homo sapiens_hsa052101.22831204
54Prostate cancer_Homo sapiens_hsa052151.22691117
55Basal transcription factors_Homo sapiens_hsa030221.20791311
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20482422
57mTOR signaling pathway_Homo sapiens_hsa041501.19844306
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19553559
59Selenocompound metabolism_Homo sapiens_hsa004501.19029558
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16240816
61Glutamatergic synapse_Homo sapiens_hsa047241.14488488
62Pathways in cancer_Homo sapiens_hsa052001.14450521
63Estrogen signaling pathway_Homo sapiens_hsa049151.13861055
64Rap1 signaling pathway_Homo sapiens_hsa040151.13356049
65Central carbon metabolism in cancer_Homo sapiens_hsa052301.10995590
66GABAergic synapse_Homo sapiens_hsa047271.10026016
67Circadian rhythm_Homo sapiens_hsa047101.09978399
68Tight junction_Homo sapiens_hsa045301.09188378
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08904995
70Pancreatic cancer_Homo sapiens_hsa052121.08545781
71Serotonergic synapse_Homo sapiens_hsa047261.03749785
72Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03230675
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01707343
74Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01255009
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98783777
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98130854
77T cell receptor signaling pathway_Homo sapiens_hsa046600.97169649
78Calcium signaling pathway_Homo sapiens_hsa040200.96597337
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95553357
80Non-small cell lung cancer_Homo sapiens_hsa052230.93252141
81GnRH signaling pathway_Homo sapiens_hsa049120.92877184
82ErbB signaling pathway_Homo sapiens_hsa040120.92161871
83Oxytocin signaling pathway_Homo sapiens_hsa049210.91819369
84Linoleic acid metabolism_Homo sapiens_hsa005910.90597638
85Regulation of autophagy_Homo sapiens_hsa041400.90324715
86Nicotine addiction_Homo sapiens_hsa050330.89827420
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88822255
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.88497949
89Ether lipid metabolism_Homo sapiens_hsa005650.87501743
90Insulin signaling pathway_Homo sapiens_hsa049100.86740806
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85106658
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.85006738
93AMPK signaling pathway_Homo sapiens_hsa041520.84772471
94Amphetamine addiction_Homo sapiens_hsa050310.84621086
95Ras signaling pathway_Homo sapiens_hsa040140.84117511
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83263616
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82210039
98Dorso-ventral axis formation_Homo sapiens_hsa043200.81722788
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81503225
100Notch signaling pathway_Homo sapiens_hsa043300.81480269
101Platelet activation_Homo sapiens_hsa046110.81292005
102HIF-1 signaling pathway_Homo sapiens_hsa040660.80912675
103Allograft rejection_Homo sapiens_hsa053300.80837468
104Malaria_Homo sapiens_hsa051440.80772879
105Asthma_Homo sapiens_hsa053100.80747448
106Graft-versus-host disease_Homo sapiens_hsa053320.80333296
107Autoimmune thyroid disease_Homo sapiens_hsa053200.79825667
108Renin secretion_Homo sapiens_hsa049240.79745341
109HTLV-I infection_Homo sapiens_hsa051660.79444258
110Propanoate metabolism_Homo sapiens_hsa006400.78461840
111VEGF signaling pathway_Homo sapiens_hsa043700.78387166
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.78285109
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78218586
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.76220213
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73228572
116FoxO signaling pathway_Homo sapiens_hsa040680.73121031
117Lysine degradation_Homo sapiens_hsa003100.72975389
118ABC transporters_Homo sapiens_hsa020100.72595065
119Type II diabetes mellitus_Homo sapiens_hsa049300.72584918
120Circadian entrainment_Homo sapiens_hsa047130.71857915
121cAMP signaling pathway_Homo sapiens_hsa040240.71397306
122Insulin resistance_Homo sapiens_hsa049310.71382562
123Salivary secretion_Homo sapiens_hsa049700.69020613
124Cholinergic synapse_Homo sapiens_hsa047250.68794356
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68147828
126Olfactory transduction_Homo sapiens_hsa047400.67795079
127MAPK signaling pathway_Homo sapiens_hsa040100.66598734
128Long-term depression_Homo sapiens_hsa047300.66062991
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65126313
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.64635275
131Ovarian steroidogenesis_Homo sapiens_hsa049130.63993248
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63343769
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63202736
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61233613
135Choline metabolism in cancer_Homo sapiens_hsa052310.60706537
136Peroxisome_Homo sapiens_hsa041460.60161435
137Toxoplasmosis_Homo sapiens_hsa051450.59951946
138Oxidative phosphorylation_Homo sapiens_hsa001900.58321220
139Prolactin signaling pathway_Homo sapiens_hsa049170.58180345
140Hematopoietic cell lineage_Homo sapiens_hsa046400.57936773
141p53 signaling pathway_Homo sapiens_hsa041150.57431902
142Tryptophan metabolism_Homo sapiens_hsa003800.55491118
143Gastric acid secretion_Homo sapiens_hsa049710.55106212
144Glycosaminoglycan degradation_Homo sapiens_hsa005310.54591586
145Cocaine addiction_Homo sapiens_hsa050300.54428481
146Dopaminergic synapse_Homo sapiens_hsa047280.54320375
147Glucagon signaling pathway_Homo sapiens_hsa049220.54308471
148Thyroid cancer_Homo sapiens_hsa052160.51700290
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50566103
150Sulfur metabolism_Homo sapiens_hsa009200.48997400
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.48539129
152Long-term potentiation_Homo sapiens_hsa047200.47337386
153Cardiac muscle contraction_Homo sapiens_hsa042600.47124819
154TNF signaling pathway_Homo sapiens_hsa046680.46860639
155Endocytosis_Homo sapiens_hsa041440.46728686
156Parkinsons disease_Homo sapiens_hsa050120.43958048
157Measles_Homo sapiens_hsa051620.43061145
158Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42666779

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