LKAAEAR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.89868111
2spermatid development (GO:0007286)9.77836824
3cilium or flagellum-dependent cell motility (GO:0001539)9.75028372
4motile cilium assembly (GO:0044458)9.60991761
5reproduction (GO:0000003)9.55360985
6aggressive behavior (GO:0002118)8.47277239
7regulation of cilium movement (GO:0003352)8.29120423
8cilium movement (GO:0003341)8.17081288
9hyperosmotic salinity response (GO:0042538)7.58332054
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.55421078
11regulation of female receptivity (GO:0045924)7.43953665
12single fertilization (GO:0007338)7.36421350
13sperm capacitation (GO:0048240)7.26808279
14negative regulation of inclusion body assembly (GO:0090084)7.23644763
15synaptonemal complex organization (GO:0070193)7.23387956
16synaptonemal complex assembly (GO:0007130)7.12092751
17regulation of transmission of nerve impulse (GO:0051969)7.04106142
18male meiosis (GO:0007140)7.00691560
19piRNA metabolic process (GO:0034587)6.97562523
20female mating behavior (GO:0060180)6.96446141
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)6.94179894
22spermatogenesis (GO:0007283)6.68177158
23male gamete generation (GO:0048232)6.65812827
24organic cation transport (GO:0015695)6.54862920
25positive regulation of amino acid transport (GO:0051957)6.32899563
26microtubule depolymerization (GO:0007019)6.31788854
27fertilization (GO:0009566)6.22629241
28gamete generation (GO:0007276)6.11543246
29regulation of inclusion body assembly (GO:0090083)5.99666694
30grooming behavior (GO:0007625)5.83673675
31drinking behavior (GO:0042756)5.77821494
32calcium ion-dependent exocytosis (GO:0017156)5.71389873
33mitochondrial calcium ion transport (GO:0006851)5.64414603
34spermatid nucleus differentiation (GO:0007289)5.62368957
35germ cell development (GO:0007281)5.41003730
36cellular process involved in reproduction in multicellular organism (GO:0022412)5.34410684
37maternal behavior (GO:0042711)5.29062226
38iron-sulfur cluster assembly (GO:0016226)5.15752030
39metallo-sulfur cluster assembly (GO:0031163)5.15752030
40chromosome condensation (GO:0030261)5.14656209
41positive regulation of systemic arterial blood pressure (GO:0003084)5.09010958
42glycerol ether metabolic process (GO:0006662)5.08086533
43ventricular system development (GO:0021591)5.06989151
44cell recognition (GO:0008037)5.04353003
45positive regulation of fatty acid biosynthetic process (GO:0045723)4.96290972
46sexual reproduction (GO:0019953)4.90140314
47positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.89696317
48regulation of microtubule-based movement (GO:0060632)4.88847303
49regulation of glutamate secretion (GO:0014048)4.88347919
50DNA packaging (GO:0006323)4.86856515
51multicellular organismal reproductive process (GO:0048609)4.80356443
52protein kinase C signaling (GO:0070528)4.80179348
53chromosome organization involved in meiosis (GO:0070192)4.77432889
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.75145962
55ether metabolic process (GO:0018904)4.69502979
56microtubule severing (GO:0051013)4.66497118
57parental behavior (GO:0060746)4.65535029
58negative regulation of necrotic cell death (GO:0060547)4.63087081
59male meiosis I (GO:0007141)4.62931157
60positive regulation of vascular permeability (GO:0043117)4.62107657
61phosphatidylglycerol biosynthetic process (GO:0006655)4.60164967
62seminiferous tubule development (GO:0072520)4.54577499
63definitive hemopoiesis (GO:0060216)4.52954541
64single strand break repair (GO:0000012)4.47501092
65DNA methylation involved in gamete generation (GO:0043046)4.46571790
66purine deoxyribonucleotide catabolic process (GO:0009155)4.38677064
67deoxyribonucleotide catabolic process (GO:0009264)4.36570536
68autophagic vacuole fusion (GO:0000046)4.33041285
69base-excision repair, AP site formation (GO:0006285)4.28460297
70negative regulation of cell size (GO:0045792)4.28192984
71left/right pattern formation (GO:0060972)4.25500905
72regulation of feeding behavior (GO:0060259)4.22228209
73meiotic nuclear division (GO:0007126)4.17046501
74chaperone-mediated protein complex assembly (GO:0051131)4.07524935
75negative regulation of release of cytochrome c from mitochondria (GO:0090201)4.05892445
76negative regulation of digestive system process (GO:0060457)4.04743566
77aerobic respiration (GO:0009060)4.01491669
78deoxyribose phosphate catabolic process (GO:0046386)4.00353079
792-deoxyribonucleotide biosynthetic process (GO:0009265)3.97710874
80deoxyribose phosphate biosynthetic process (GO:0046385)3.97710874
81protein K11-linked deubiquitination (GO:0035871)3.94278501
82negative regulation of response to food (GO:0032096)3.92035203
83negative regulation of appetite (GO:0032099)3.92035203
84multicellular organismal development (GO:0007275)3.86118773
85pyrimidine nucleotide catabolic process (GO:0006244)3.82836756
86sodium-independent organic anion transport (GO:0043252)3.78793081
87negative regulation of neurological system process (GO:0031645)3.78252756
88sequestering of actin monomers (GO:0042989)3.71736884
89meiosis I (GO:0007127)3.69571934
90positive regulation of organic acid transport (GO:0032892)3.67555508
91guanosine-containing compound biosynthetic process (GO:1901070)3.66654370
92deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.63323783
93genitalia morphogenesis (GO:0035112)3.56660826
94UTP metabolic process (GO:0046051)3.56431487
95mitochondrion transport along microtubule (GO:0047497)3.55321962
96establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.55321962
97ubiquinone biosynthetic process (GO:0006744)3.53288808
98pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.46327468
99positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.43627947
100regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.43627947
101GMP metabolic process (GO:0046037)3.41795090
1022-deoxyribonucleotide metabolic process (GO:0009394)3.41505315
103pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.41422696
104mitochondrial calcium ion homeostasis (GO:0051560)3.40827634
105monoubiquitinated protein deubiquitination (GO:0035520)3.39503865
106protein refolding (GO:0042026)3.38776418
107protein polyglutamylation (GO:0018095)3.37915674
108purine deoxyribonucleotide metabolic process (GO:0009151)3.37587316
109meiotic cell cycle (GO:0051321)3.37414975
110ganglioside metabolic process (GO:0001573)3.34885976
111organelle membrane fusion (GO:0090174)3.32172827
112establishment of mitochondrion localization (GO:0051654)3.31635459
113microtubule polymerization or depolymerization (GO:0031109)3.30565022
114mature B cell differentiation involved in immune response (GO:0002313)3.30330838
115purine nucleotide salvage (GO:0032261)3.27739718
116telomere maintenance via semi-conservative replication (GO:0032201)3.26184405
117regulation of spindle checkpoint (GO:0090231)3.19928223
118protein localization to cilium (GO:0061512)3.19403509
119response to testosterone (GO:0033574)3.17694210
120cardiolipin metabolic process (GO:0032048)3.15261134
121deoxyribose phosphate metabolic process (GO:0019692)3.14874238
122glycolytic process (GO:0006096)3.10362795
123nucleus organization (GO:0006997)3.08472817
124base-excision repair (GO:0006284)3.07651723
125ubiquinone metabolic process (GO:0006743)3.06359137
126positive regulation of macrophage activation (GO:0043032)3.04605173
127regulation of necrotic cell death (GO:0010939)3.04029347
128purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.03881249
129nucleoside diphosphate phosphorylation (GO:0006165)3.02936848
130carnitine transport (GO:0015879)3.02548134
131amino-acid betaine transport (GO:0015838)3.02548134
132negative regulation of B cell apoptotic process (GO:0002903)3.01632243
133positive regulation of prostaglandin secretion (GO:0032308)3.00175242
134regulation of skeletal muscle contraction (GO:0014819)3.00017332
135negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.99531557
136pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.99476901
137CTP metabolic process (GO:0046036)2.99388311
138CTP biosynthetic process (GO:0006241)2.99388311
139polyol catabolic process (GO:0046174)2.97572451
140response to peptidoglycan (GO:0032494)2.97527963
141negative regulation of myeloid cell apoptotic process (GO:0033033)2.92410525
142alditol metabolic process (GO:0019400)2.91952977
143deoxyribonucleotide metabolic process (GO:0009262)2.91838613
144nucleotide salvage (GO:0043173)2.91709936
145pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.91269188
146response to nitrosative stress (GO:0051409)2.90352238
147hyperosmotic response (GO:0006972)2.87502725
148pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.86980639
149carnitine transmembrane transport (GO:1902603)2.85806015
150mitotic sister chromatid cohesion (GO:0007064)2.85723206
151pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.84863454
152cilium organization (GO:0044782)2.84335449
153mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83684381
154mitochondrial respiratory chain complex I assembly (GO:0032981)2.83684381
155NADH dehydrogenase complex assembly (GO:0010257)2.83684381
156deoxyribonucleotide biosynthetic process (GO:0009263)2.82665495
157translesion synthesis (GO:0019985)2.81921295
158quinone biosynthetic process (GO:1901663)2.81505731
159protein complex biogenesis (GO:0070271)2.81464711
160interferon-gamma secretion (GO:0072643)2.80177077
161microtubule-based movement (GO:0007018)2.80016580
162estrogen biosynthetic process (GO:0006703)2.78687818
163polyamine biosynthetic process (GO:0006596)2.76564609
164intraciliary transport (GO:0042073)2.76014607
165GDP-mannose metabolic process (GO:0019673)2.75312333
166DNA strand elongation involved in DNA replication (GO:0006271)2.75260637
167positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.73787639
168meiotic cell cycle process (GO:1903046)2.73529566
169cilium assembly (GO:0042384)2.73360245
170GTP biosynthetic process (GO:0006183)2.72698249
171chromatin silencing (GO:0006342)2.70735415
172axoneme assembly (GO:0035082)2.70557075
173cellular component assembly involved in morphogenesis (GO:0010927)2.70164955
174regulation of cilium assembly (GO:1902017)2.68002277
175cilium morphogenesis (GO:0060271)2.65144440
176centriole assembly (GO:0098534)2.63439718
177RNA localization (GO:0006403)2.61920527
178synapsis (GO:0007129)2.61779902
179lactate metabolic process (GO:0006089)2.58998177
180negative regulation of organelle assembly (GO:1902116)2.52975641
181glycerol metabolic process (GO:0006071)2.48590035
182RNA destabilization (GO:0050779)2.47022057
183gene silencing by RNA (GO:0031047)2.42484562
184UTP biosynthetic process (GO:0006228)2.41772558
185cell wall macromolecule metabolic process (GO:0044036)14.0126942
186cell wall macromolecule catabolic process (GO:0016998)14.0126942
187sperm motility (GO:0030317)13.9516734
188fusion of sperm to egg plasma membrane (GO:0007342)13.3769983
189acrosome reaction (GO:0007340)12.1645228
190acrosome assembly (GO:0001675)11.7151908
191sperm-egg recognition (GO:0035036)11.6699354
192multicellular organism reproduction (GO:0032504)10.8828117
193binding of sperm to zona pellucida (GO:0007339)10.6511303
194cell-cell recognition (GO:0009988)10.4500308
195plasma membrane fusion (GO:0045026)10.1836129
196epithelial cilium movement (GO:0003351)10.1201882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.55624140
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.52450968
3E2F7_22180533_ChIP-Seq_HELA_Human4.91475889
4EZH2_22144423_ChIP-Seq_EOC_Human4.17847075
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.97046531
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.63830941
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.38611208
8SCL_19346495_ChIP-Seq_HPC-7_Human3.32279770
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09890261
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.99968053
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.85539895
12VDR_21846776_ChIP-Seq_THP-1_Human2.82174532
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72246833
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.52688886
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50892590
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.42725942
17VDR_22108803_ChIP-Seq_LS180_Human2.33391332
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32992734
19ESR1_15608294_ChIP-ChIP_MCF-7_Human2.31636934
20BCL6_27268052_Chip-Seq_Bcells_Human2.28629985
21CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.24703765
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23103962
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.22756696
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.20689641
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20192279
26GATA1_26923725_Chip-Seq_HPCs_Mouse2.14628610
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.12709159
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09394482
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03331100
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.02354992
31ZNF274_21170338_ChIP-Seq_K562_Hela2.01595772
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98921050
33P68_20966046_ChIP-Seq_HELA_Human1.89967353
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.89165282
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.82181144
36KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82052225
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81565431
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77732496
39CTCF_18555785_ChIP-Seq_MESCs_Mouse1.76039673
40ELK4_26923725_Chip-Seq_MESODERM_Mouse1.75569878
41TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.72159125
42STAT1_17558387_ChIP-Seq_HELA_Human1.69670081
43VDR_24763502_ChIP-Seq_THP-1_Human1.68878183
44FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67061038
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64371574
46MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63931425
47SOX2_22085726_ChIP-Seq_NPCs_Mouse1.62814545
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61461631
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.61073947
50LXR_22292898_ChIP-Seq_THP-1_Human1.60560365
51E2F1_20622854_ChIP-Seq_HELA_Human1.60155213
52GATA3_21867929_ChIP-Seq_CD8_Mouse1.57857944
53GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.56437481
54BCOR_27268052_Chip-Seq_Bcells_Human1.55854345
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54728020
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.52796301
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.52547568
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.52175299
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50955398
60GABP_19822575_ChIP-Seq_HepG2_Human1.50849966
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50559463
62KDM2B_26808549_Chip-Seq_REH_Human1.50143207
63KAP1_22055183_ChIP-Seq_ESCs_Mouse1.49214928
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.48378262
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47865710
66ERA_21632823_ChIP-Seq_H3396_Human1.46803743
67PHF8_20622854_ChIP-Seq_HELA_Human1.44850464
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.42301771
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42000047
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41272732
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40978223
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39341962
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38604721
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38537366
75FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38214157
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38100735
77CBP_20019798_ChIP-Seq_JUKART_Human1.38100735
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37863317
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37623720
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37163114
81MAF_26560356_Chip-Seq_TH1_Human1.37140726
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36036217
83CTCF_21964334_ChIP-Seq_BJAB-B_Human1.35484223
84P53_21459846_ChIP-Seq_SAOS-2_Human1.35264861
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35163010
86LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34161595
87REST_21632747_ChIP-Seq_MESCs_Mouse1.34011806
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31941139
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31226682
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31130338
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30713887
92FOXP1_21924763_ChIP-Seq_HESCs_Human1.30075723
93CIITA_25753668_ChIP-Seq_RAJI_Human1.28717950
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28453319
95VDR_23849224_ChIP-Seq_CD4+_Human1.28453238
96GATA3_21867929_ChIP-Seq_TH1_Mouse1.28113234
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.27957894
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26648593
99P300_27268052_Chip-Seq_Bcells_Human1.26163852
100SPI1_23547873_ChIP-Seq_NB4_Human1.25587906
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25325227
102ETS1_21867929_ChIP-Seq_TH2_Mouse1.25235211
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25042724
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.24932033
105UTX_26944678_Chip-Seq_JUKART_Human1.24799627
106PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24364212
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22342955
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22101636
109GF1_26923725_Chip-Seq_HPCs_Mouse1.20922946
110RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19724364
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19606557
112CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18731847
113SRF_21415370_ChIP-Seq_HL-1_Mouse1.18367935
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18241839
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17638349
116STAT1_20625510_ChIP-Seq_HELA_Human1.17177050
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16956215
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16275586
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14415848
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14415848
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13985974
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13865953
123SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13769053
124SMC4_20622854_ChIP-Seq_HELA_Human1.12856186
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12796692
126SPI1_26923725_Chip-Seq_HPCs_Mouse1.12214984
127CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12166851
128MYB_26560356_Chip-Seq_TH2_Human1.12096571
129MYC_22102868_ChIP-Seq_BL_Human1.11537540
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11052520
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10867713
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.10790668
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10104030
134NANOG_18555785_Chip-Seq_ESCs_Mouse1.09713745
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09247931
136RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08386071
137SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07637673
138SA1_27219007_Chip-Seq_Bcells_Human1.07289549
139SA1_27219007_Chip-Seq_ERYTHROID_Human1.07248716
140ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06484463
141FOXP3_21729870_ChIP-Seq_TREG_Human1.06097381
142KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06039035
143PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06003720
144NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05819398
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05306825
146CTCF_26484167_Chip-Seq_Bcells_Mouse1.04847254
147GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04461574
148CTCF_21964334_Chip-Seq_Bcells_Human1.04425569
149YY1_22570637_ChIP-Seq_MALME-3M_Human1.04410842
150GATA1_22025678_ChIP-Seq_K562_Human1.04400157
151ERG_20517297_ChIP-Seq_VCAP_Human1.04257886
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04222027
153THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03879551
154IRF8_21731497_ChIP-ChIP_J774_Mouse1.03857513
155ESET_19884257_ChIP-Seq_ESCs_Mouse1.03753118
156CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03649216
157SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03628946
158EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03487866
159RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02515786
160RARA_24833708_ChIP-Seq_LIVER_Mouse1.01738125
161ERG_21242973_ChIP-ChIP_JURKAT_Human1.01351059
162OCT4_18555785_Chip-Seq_ESCs_Mouse1.00977901
163P53_22387025_ChIP-Seq_ESCs_Mouse1.00675293
164SPI1_20517297_ChIP-Seq_HL60_Human1.00312327
165ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00302231
166MYC_27129775_Chip-Seq_CORNEA_Mouse1.00137780
167SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99948907
168DCP1A_22483619_ChIP-Seq_HELA_Human0.99647690
169KDM5A_27292631_Chip-Seq_BREAST_Human0.99353815
170MAF_26560356_Chip-Seq_TH2_Human0.99260188
171RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98726736
172EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98318447
173LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98207999
174MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98010552
175TET1_21451524_ChIP-Seq_MESCs_Mouse0.97989556
176CMYC_18555785_Chip-Seq_ESCs_Mouse0.97427555
177PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96978375
178SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96500479
179TAF15_26573619_Chip-Seq_HEK293_Human0.94770048
180JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94599913
181SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94195418
182KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.93912697
183P300_18555785_Chip-Seq_ESCs_Mouse0.93123718
184FLI1_21867929_ChIP-Seq_CD8_Mouse0.92972583
185KLF4_18555785_Chip-Seq_ESCs_Mouse0.92532822
186PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90702856
187NFYB_21822215_ChIP-Seq_K562_Human0.90675191
188OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89912127
189ELF1_20517297_ChIP-Seq_JURKAT_Human0.89231242
190ESRRB_18555785_Chip-Seq_ESCs_Mouse0.88967849
191CTCF_20526341_ChIP-Seq_ESCs_Human0.88362290
192SOX9_26525672_Chip-Seq_HEART_Mouse0.88112617

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08993976
2MP0001929_abnormal_gametogenesis5.59177138
3MP0005645_abnormal_hypothalamus_physiol5.18668156
4MP0003806_abnormal_nucleotide_metabolis4.03382617
5MP0008877_abnormal_DNA_methylation4.01476428
6MP0000465_gastrointestinal_hemorrhage3.89218601
7MP0005451_abnormal_body_composition3.47072344
8MP0002210_abnormal_sex_determination3.38612154
9MP0002161_abnormal_fertility/fecundity3.30488895
10MP0002822_catalepsy2.94473225
11MP0005670_abnormal_white_adipose2.87137494
12MP0001145_abnormal_male_reproductive2.87074629
13MP0000653_abnormal_sex_gland2.48307752
14MP0002653_abnormal_ependyma_morphology2.35519423
15MP0003718_maternal_effect2.03181728
16MP0005410_abnormal_fertilization16.6173812
17MP0008004_abnormal_stomach_pH1.81625540
18MP0002132_abnormal_respiratory_system1.74765547
19MP0002396_abnormal_hematopoietic_system1.69219572
20MP0008789_abnormal_olfactory_epithelium1.67021602
21MP0003646_muscle_fatigue1.65316377
22MP0009840_abnormal_foam_cell1.63723111
23MP0002638_abnormal_pupillary_reflex1.62338784
24MP0002733_abnormal_thermal_nociception1.61605965
25MP0002160_abnormal_reproductive_system1.61570053
26MP0005464_abnormal_platelet_physiology1.60873893
27MP0006276_abnormal_autonomic_nervous1.60656100
28MP0003436_decreased_susceptibility_to1.55690972
29MP0004233_abnormal_muscle_weight1.53900696
30MP0001835_abnormal_antigen_presentation1.53195593
31MP0003191_abnormal_cellular_cholesterol1.52584265
32MP0009697_abnormal_copulation1.45315639
33MP0008875_abnormal_xenobiotic_pharmacok1.41868492
34MP0005394_taste/olfaction_phenotype1.41002122
35MP0005499_abnormal_olfactory_system1.41002122
36MP0005623_abnormal_meninges_morphology1.37503153
37MP0005025_abnormal_response_to1.35796875
38MP0002282_abnormal_trachea_morphology1.31724667
39MP0002148_abnormal_hypersensitivity_rea1.21573886
40MP0002398_abnormal_bone_marrow1.18179583
41MP0002735_abnormal_chemical_nociception1.17412092
42MP0003866_abnormal_defecation1.17357374
43MP0001765_abnormal_ion_homeostasis1.14449827
44MP0002420_abnormal_adaptive_immunity1.07586135
45MP0000716_abnormal_immune_system1.06223420
46MP0001819_abnormal_immune_cell1.05798742
47MP0002019_abnormal_tumor_incidence1.02552026
48MP0002419_abnormal_innate_immunity1.02403711
49MP0000689_abnormal_spleen_morphology1.02315700
50MP0000681_abnormal_thyroid_gland1.02100929
51MP0001970_abnormal_pain_threshold1.00964748
52MP0005266_abnormal_metabolism1.00630993
53MP0003186_abnormal_redox_activity0.98820740
54MP0001984_abnormal_olfaction0.98635634
55MP0003763_abnormal_thymus_physiology0.98218304
56MP0001905_abnormal_dopamine_level0.97507189
57MP0002452_abnormal_antigen_presenting0.97038844
58MP0005220_abnormal_exocrine_pancreas0.95583759
59MP0002429_abnormal_blood_cell0.94320500
60MP0000490_abnormal_crypts_of0.93802627
61MP0002234_abnormal_pharynx_morphology0.93326785
62MP0005000_abnormal_immune_tolerance0.90316663
63MP0005058_abnormal_lysosome_morphology0.90122090
64MP0004859_abnormal_synaptic_plasticity0.89992985
65MP0001529_abnormal_vocalization0.88898557
66MP0002722_abnormal_immune_system0.88595374
67MP0008058_abnormal_DNA_repair0.88183996
68MP0009379_abnormal_foot_pigmentation0.86155474
69MP0000685_abnormal_immune_system0.84792060
70MP0002723_abnormal_immune_serum0.83040788
71MP0004142_abnormal_muscle_tone0.82289011
72MP0008872_abnormal_physiological_respon0.81476060
73MP0003121_genomic_imprinting0.81278493
74MP0005647_abnormal_sex_gland0.80944611
75MP0008873_increased_physiological_sensi0.80023608
76MP0003075_altered_response_to0.78884364
77MP0009046_muscle_twitch0.78036768
78MP0005389_reproductive_system_phenotype0.76856072
79MP0000516_abnormal_urinary_system0.76316073
80MP0005367_renal/urinary_system_phenotyp0.76316073
81MP0001881_abnormal_mammary_gland0.75051826
82MP0001664_abnormal_digestion0.73557910
83MP0004808_abnormal_hematopoietic_stem0.72505917
84MP0001851_eye_inflammation0.71917520
85MP0003880_abnormal_central_pattern0.70192069
86MP0001800_abnormal_humoral_immune0.70133874
87MP0005387_immune_system_phenotype0.70114817
88MP0001790_abnormal_immune_system0.70114817
89MP0005084_abnormal_gallbladder_morpholo0.69223889
90MP0009764_decreased_sensitivity_to0.68418234
91MP0005334_abnormal_fat_pad0.67761579
92MP0008260_abnormal_autophagy0.67639581
93MP0004782_abnormal_surfactant_physiolog0.64245101
94MP0005636_abnormal_mineral_homeostasis0.63754904
95MP0001853_heart_inflammation0.62466448
96MP0008995_early_reproductive_senescence0.62314884
97MP0009333_abnormal_splenocyte_physiolog0.62024177
98MP0005423_abnormal_somatic_nervous0.61393133
99MP0005671_abnormal_response_to0.60345113
100MP0002067_abnormal_sensory_capabilities0.59017521
101MP0003011_delayed_dark_adaptation0.58019444
102MP0003115_abnormal_respiratory_system0.57692662
103MP0000358_abnormal_cell_content/0.54394549
104MP0002269_muscular_atrophy0.53395157
105MP0003329_amyloid_beta_deposits0.49687295
106MP0004036_abnormal_muscle_relaxation0.48606232
107MP0001764_abnormal_homeostasis0.47804872
108MP0005666_abnormal_adipose_tissue0.47705429
109MP0001324_abnormal_eye_pigmentation0.47102702
110MP0006036_abnormal_mitochondrial_physio0.46374826
111MP0010094_abnormal_chromosome_stability0.44626416
112MP0002928_abnormal_bile_duct0.44183945
113MP0002736_abnormal_nociception_after0.43849460
114MP0003699_abnormal_female_reproductive0.43298527
115MP0003878_abnormal_ear_physiology0.41972796
116MP0005377_hearing/vestibular/ear_phenot0.41972796
117MP0003950_abnormal_plasma_membrane0.41175080
118MP0005397_hematopoietic_system_phenotyp0.39282777
119MP0001545_abnormal_hematopoietic_system0.39282777
120MP0009278_abnormal_bone_marrow0.37821200
121MP0005253_abnormal_eye_physiology0.37390295
122MP0000569_abnormal_digit_pigmentation0.37120827
123MP0009115_abnormal_fat_cell0.36284060
124MP0005551_abnormal_eye_electrophysiolog0.35484814
125MP0003787_abnormal_imprinting0.33625494
126MP0001293_anophthalmia0.33013759
127MP0002909_abnormal_adrenal_gland0.31634256
128MP0004133_heterotaxia0.30423086
129MP0002693_abnormal_pancreas_physiology0.29742414
130MP0000534_abnormal_ureter_morphology0.29734783
131MP0004019_abnormal_vitamin_homeostasis0.28574401
132MP0002102_abnormal_ear_morphology0.28428274
133MP0001348_abnormal_lacrimal_gland0.27807999
134MP0003183_abnormal_peptide_metabolism0.27606166
135MP0002971_abnormal_brown_adipose0.27573768
136MP0003786_premature_aging0.27495594
137MP0005503_abnormal_tendon_morphology0.25904590
138MP0001119_abnormal_female_reproductive0.25805176
139MP0004811_abnormal_neuron_physiology0.25527083
140MP0003879_abnormal_hair_cell0.25464863
141MP0001270_distended_abdomen0.25045924
142MP0002139_abnormal_hepatobiliary_system0.24918254
143MP0006035_abnormal_mitochondrial_morpho0.24844137
144MP0000604_amyloidosis0.24839104
145MP0003633_abnormal_nervous_system0.24621730
146MP0005391_vision/eye_phenotype0.24448580
147MP0003111_abnormal_nucleus_morphology0.23507958
148MP0004043_abnormal_pH_regulation0.23140334
149MP0004134_abnormal_chest_morphology0.22175469
150MP0002163_abnormal_gland_morphology0.21789005
151MP0001968_abnormal_touch/_nociception0.21696298
152MP0003948_abnormal_gas_homeostasis0.21668784
153MP0003942_abnormal_urinary_system0.21121898
154MP0002169_no_abnormal_phenotype0.20429760
155MP0002873_normal_phenotype0.20192784
156MP0003631_nervous_system_phenotype0.18721889
157MP0001730_embryonic_growth_arrest0.18595116
158MP0002152_abnormal_brain_morphology0.17511420
159MP0003861_abnormal_nervous_system0.16451080
160MP0003959_abnormal_lean_body0.16364940
161MP0008961_abnormal_basal_metabolism0.16321187
162MP0004742_abnormal_vestibular_system0.16066432
163MP0008007_abnormal_cellular_replicative0.15702201
164MP0010307_abnormal_tumor_latency0.15580906
165MP0008057_abnormal_DNA_replication0.14964500
166MP0009250_abnormal_appendicular_skeleto0.14256547
167MP0005319_abnormal_enzyme/_coenzyme0.14105600
168MP0000313_abnormal_cell_death0.13717454
169MP0002405_respiratory_system_inflammati0.13634265
170MP0002295_abnormal_pulmonary_circulatio0.13448191
171MP0002108_abnormal_muscle_morphology0.13092533
172MP0000751_myopathy0.12793673
173MP0002229_neurodegeneration0.12773272
174MP0005535_abnormal_body_temperature0.12771018
175MP0000001_mammalian_phenotype0.12642915
176MP0001986_abnormal_taste_sensitivity0.12558855

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.34545370
2Abnormal respiratory epithelium morphology (HP:0012253)9.33448321
3Abnormal respiratory motile cilium morphology (HP:0005938)9.33448321
4Rhinitis (HP:0012384)7.61952919
5Chronic bronchitis (HP:0004469)7.51999851
6Abnormal ciliary motility (HP:0012262)7.35883361
7Infertility (HP:0000789)6.87112870
8Nasal polyposis (HP:0100582)6.51753755
9Abnormality of the nasal mucosa (HP:0000433)5.33781113
10Failure to thrive in infancy (HP:0001531)4.82504938
11Bronchitis (HP:0012387)4.60653126
12Bronchiectasis (HP:0002110)4.49219367
13Male infertility (HP:0003251)4.32634654
14Nephronophthisis (HP:0000090)4.05917190
15Metaphyseal dysplasia (HP:0100255)3.93798937
16Hepatocellular necrosis (HP:0001404)3.52868790
17Vacuolated lymphocytes (HP:0001922)3.49287427
18Mitochondrial inheritance (HP:0001427)3.41031816
19Abnormal spermatogenesis (HP:0008669)3.38705546
20Recurrent otitis media (HP:0000403)3.34451239
21Increased intramyocellular lipid droplets (HP:0012240)3.33838303
22Recurrent sinusitis (HP:0011108)3.30374419
23Dysautonomia (HP:0002459)3.22686984
24Abnormal mitochondria in muscle tissue (HP:0008316)3.19231800
25Increased muscle lipid content (HP:0009058)3.19121682
26Stomatitis (HP:0010280)3.18629279
27Agammaglobulinemia (HP:0004432)3.12837198
28Increased neuronal autofluorescent lipopigment (HP:0002074)3.12679053
29Abnormal pupillary function (HP:0007686)3.06387118
30Abnormality of the renal medulla (HP:0100957)3.05542967
31Hepatic necrosis (HP:0002605)3.03875380
32Acute necrotizing encephalopathy (HP:0006965)3.01851616
33Elevated erythrocyte sedimentation rate (HP:0003565)3.00639081
34Abnormal rod and cone electroretinograms (HP:0008323)2.86223105
35Obstructive lung disease (HP:0006536)2.84815347
36Chronic obstructive pulmonary disease (HP:0006510)2.84815347
37Tubulointerstitial nephritis (HP:0001970)2.75685227
38Gliosis (HP:0002171)2.74450419
39Progressive microcephaly (HP:0000253)2.70847266
40Congenital stationary night blindness (HP:0007642)2.69689650
41Recurrent bronchitis (HP:0002837)2.66421976
42Increased cerebral lipofuscin (HP:0011813)2.66105211
43Microvesicular hepatic steatosis (HP:0001414)2.63116122
44Orthostatic hypotension (HP:0001278)2.59135704
45Medial flaring of the eyebrow (HP:0010747)2.58656975
46Acute encephalopathy (HP:0006846)2.58609338
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.52795881
48Severe global developmental delay (HP:0011344)2.52552050
49Abnormality of midbrain morphology (HP:0002418)2.49931222
50Molar tooth sign on MRI (HP:0002419)2.49931222
51Abnormality of the prostate (HP:0008775)2.49901277
52Elfin facies (HP:0004428)2.48279030
53Impulsivity (HP:0100710)2.46715137
54Amelogenesis imperfecta (HP:0000705)2.44375070
55Tubular atrophy (HP:0000092)2.42912176
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.42824429
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.42824429
58Type I transferrin isoform profile (HP:0003642)2.41889968
59Increased CSF lactate (HP:0002490)2.41394362
60Hypertensive crisis (HP:0100735)2.41160032
61Rhabdomyolysis (HP:0003201)2.39965600
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.35841087
63Progressive macrocephaly (HP:0004481)2.34379589
64Abnormal autonomic nervous system physiology (HP:0012332)2.31532010
65Abnormal gallbladder physiology (HP:0012438)2.29190248
66Cholecystitis (HP:0001082)2.29190248
67Tubulointerstitial abnormality (HP:0001969)2.27549065
68Panhypogammaglobulinemia (HP:0003139)2.27417945
69Recurrent fungal infections (HP:0002841)2.25456628
70Mediastinal lymphadenopathy (HP:0100721)2.25350916
71Gonadotropin excess (HP:0000837)2.24377952
72Renovascular hypertension (HP:0100817)2.23565979
73Severe combined immunodeficiency (HP:0004430)2.23035063
74B lymphocytopenia (HP:0010976)2.22207854
75Chronic otitis media (HP:0000389)2.21942536
76Azoospermia (HP:0000027)2.21633196
77Abnormality of B cell number (HP:0010975)2.16859308
78Seborrheic dermatitis (HP:0001051)2.15259895
79Severe visual impairment (HP:0001141)2.13615809
80Increased IgM level (HP:0003496)2.10601516
81Inability to walk (HP:0002540)2.10495357
82Exercise intolerance (HP:0003546)2.08114230
83Dicarboxylic aciduria (HP:0003215)2.07854304
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07854304
85Polyphagia (HP:0002591)2.07488892
86Dyschromatopsia (HP:0007641)2.06281258
87Areflexia of lower limbs (HP:0002522)2.05997296
88Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05055580
89Acute lymphatic leukemia (HP:0006721)2.04903952
90Autoimmune hemolytic anemia (HP:0001890)2.04610662
91Insomnia (HP:0100785)2.03700468
92Hyperthyroidism (HP:0000836)2.03648373
93Abnormal hair whorl (HP:0010721)2.03602122
94Myoglobinuria (HP:0002913)2.02822640
95Lactic acidosis (HP:0003128)2.02764131
96Respiratory failure (HP:0002878)2.01926922
97Cerebral edema (HP:0002181)2.01785116
98Overriding aorta (HP:0002623)2.00563511
99Dynein arm defect of respiratory motile cilia (HP:0012255)13.4473511
100Absent/shortened dynein arms (HP:0200106)13.4473511
101Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1773353
102Patent foramen ovale (HP:0001655)1.94702116
103Dysphonia (HP:0001618)1.91730223
104Epiphyseal dysplasia (HP:0002656)1.91629681
105Aplasia/Hypoplasia of the thymus (HP:0010515)1.89892262
106Alacrima (HP:0000522)1.87846938
107Prostate neoplasm (HP:0100787)1.87417025
108Hyperacusis (HP:0010780)1.86484315
109Oligomenorrhea (HP:0000876)1.85620513
110Granulocytopenia (HP:0001913)1.85513954
111Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84726060
112Spastic tetraparesis (HP:0001285)1.83715767
113Thrombocytosis (HP:0001894)1.83304247
114Emotional lability (HP:0000712)1.81835009
115Psychosis (HP:0000709)1.81702628
116Meningitis (HP:0001287)1.80896946
117Tubulointerstitial fibrosis (HP:0005576)1.76427346
118Postaxial foot polydactyly (HP:0001830)1.73045401
119Stage 5 chronic kidney disease (HP:0003774)1.70754096
120Choroideremia (HP:0001139)1.69565636
121Decreased central vision (HP:0007663)1.68882039
122Abnormal drinking behavior (HP:0030082)1.65552038
123Polydipsia (HP:0001959)1.65552038
124Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63585376
125Absent epiphyses (HP:0010577)1.63585376
126Fibular hypoplasia (HP:0003038)1.63510041
127Congenital hepatic fibrosis (HP:0002612)1.61048192
128Bile duct proliferation (HP:0001408)1.60991961
129Abnormal biliary tract physiology (HP:0012439)1.60991961
130Abnormality of renal excretion (HP:0011036)1.60407263
131Heterotopia (HP:0002282)1.59646314
132Abnormality of the renal cortex (HP:0011035)1.58778593
133Short ribs (HP:0000773)1.58112460
134Aplasia/Hypoplasia of the lens (HP:0008063)1.58082402
135Chronic sinusitis (HP:0011109)1.54242675
136Asymmetric septal hypertrophy (HP:0001670)1.52265110
137Abnormality of the dental root (HP:0006486)1.52011458
138Taurodontia (HP:0000679)1.52011458
139Abnormality of permanent molar morphology (HP:0011071)1.52011458
140Double outlet right ventricle (HP:0001719)1.50857939
141Congenital malformation of the right heart (HP:0011723)1.50857939
142Congenital primary aphakia (HP:0007707)1.49607076
143Gait imbalance (HP:0002141)1.48945078
144Sensory axonal neuropathy (HP:0003390)1.48867400
145Abnormality of dentin (HP:0010299)1.47862856
146Bell-shaped thorax (HP:0001591)1.47098537
147Hemorrhage of the eye (HP:0011885)1.46481424
148Oculomotor apraxia (HP:0000657)1.46405716
149Neurofibrillary tangles (HP:0002185)1.45926151
150Short femoral neck (HP:0100864)1.45872291
151Abnormality of the lower motor neuron (HP:0002366)1.45011849
152Postaxial hand polydactyly (HP:0001162)1.42908269
153Abnormality of the dental pulp (HP:0006479)1.41945665
154Abnormality of molar (HP:0011077)1.39671050
155Abnormality of molar morphology (HP:0011070)1.39671050
156Bundle branch block (HP:0011710)1.36394521
157Renal dysplasia (HP:0000110)1.36118686
158Easy fatigability (HP:0003388)1.33734959
159Fatigable weakness (HP:0003473)1.33594466
160Abnormality of the neuromuscular junction (HP:0003398)1.33594466
161Constricted visual fields (HP:0001133)1.32849809
162Amyotrophic lateral sclerosis (HP:0007354)1.30796778
163Cystic liver disease (HP:0006706)1.30486437
164Decreased electroretinogram (ERG) amplitude (HP:0000654)1.29644497
165Absent frontal sinuses (HP:0002688)1.28521036
166Facial cleft (HP:0002006)1.26842646
167Nephrogenic diabetes insipidus (HP:0009806)1.26227832
168Abnormal urine output (HP:0012590)1.25931712
169Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.25477875
170Short thorax (HP:0010306)1.25251483
171Cerebellar dysplasia (HP:0007033)1.24319981
172Deformed sella turcica (HP:0002681)1.22478945
173Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.20701895
174Pancreatic fibrosis (HP:0100732)1.19514000
175Loss of speech (HP:0002371)1.18916580
176Impaired proprioception (HP:0010831)1.18479703
177Exercise-induced myalgia (HP:0003738)1.18186977
178Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.17851042
179Vascular calcification (HP:0004934)1.16053055
180Cerebral inclusion bodies (HP:0100314)1.15557006
181Type 2 muscle fiber atrophy (HP:0003554)1.15474148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.61930086
2PDK38.61930086
3MAP4K16.12618684
4TESK16.09203881
5MAP3K116.06109886
6PDK25.60347853
7SCYL25.02956659
8PRKD34.50639753
9ICK4.18739592
10KDR3.19985806
11TAOK32.51850277
12VRK22.41590051
13NME12.36080953
14PIK3CG2.32746208
15NME22.19789598
16ZAK2.12751197
17BCKDK2.08355958
18PTK2B2.08289934
19PIM22.05840051
20WNK42.03242426
21STK391.93235372
22PRKD21.91204093
23PNCK1.70227638
24KIT1.68580070
25STK381.68384483
26FLT31.67268130
27NEK21.57779307
28ABL21.50125458
29BMPR1B1.50051201
30DYRK1B1.49571296
31FES1.39070623
32TLK11.33507356
33BTK1.25681227
34TBK11.19725324
35PDK11.18846683
36SMG11.17781896
37MAPKAPK31.17773943
38MAP3K71.10719012
39VRK11.02820324
40TEC0.98123804
41CDK90.97111692
42RPS6KB20.97074924
43MAP2K20.94490243
44PASK0.93927702
45IRAK10.91522810
46TNK20.90722073
47MAPK150.90482911
48DAPK10.90070403
49DYRK30.86024387
50TXK0.85841317
51SYK0.81964060
52TAF10.80180512
53JAK30.77818544
54WNK10.77328387
55CCNB10.76092102
56CSNK1G30.73173577
57TYRO30.71261950
58PDPK10.69532115
59MAP2K30.67927333
60DYRK1A0.67750525
61STK30.67077188
62IKBKB0.66774994
63GRK50.66207321
64RIPK40.64603729
65DYRK20.63725401
66GRK60.62243975
67PINK10.57180112
68GRK10.56690343
69CSNK1A1L0.56106638
70LMTK20.54152212
71CHEK20.53995633
72CSNK1G20.53011920
73TAOK20.52186107
74STK38L0.52111369
75MAP3K140.51329040
76TESK20.51273758
77CDK70.50746385
78EEF2K0.50339758
79MAP2K60.50176169
80TTK0.47053392
81HIPK20.47030595
82MAPK130.46925496
83IRAK20.44162571
84ABL10.43462914
85LYN0.43123828
86ITK0.42058750
87BMPR20.42014555
88RPS6KA60.41587286
89IKBKE0.40598499
90ADRBK20.39886704
91RPS6KC10.39724829
92RPS6KL10.39724829
93TYK20.39372342
94PLK40.38288210
95NTRK20.36970995
96CAMK1G0.36319093
97PRKD10.36277089
98PRKCG0.35786822
99CHEK10.35618473
100MUSK0.35189884
101INSRR0.34882153
102LCK0.34798489
103PAK10.34220359
104MAPK40.33706093
105RPS6KA50.32814517
106ADRBK10.32653085
107MAP2K70.32606139
108MAP2K40.30381071
109CSNK1G10.29922344
110TAOK10.29686224
111CDK190.29587654
112RPS6KA40.28808957
113DAPK30.28519696
114HCK0.25956959
115FYN0.24491090
116BRSK20.24477321
117BCR0.24215608
118ATM0.23145985
119LRRK20.23065098
120BRAF0.22225882
121MTOR0.21503104
122ATR0.20677800
123MAPKAPK50.20306140
124CAMKK10.20151082
125MAP3K100.20076408
126MARK20.19858703
127PAK20.19791066
128NEK60.18080475
129PRKAA10.17344120
130PRKCZ0.16794724
131PAK40.16457979
132PRKG20.15557647
133RPS6KB10.15249782
134PRKCQ0.14393770
135WEE10.14066528
136MARK30.13723406
137CDK150.13402175
138PLK10.11456527
139CDC70.11160871
140CDK180.11121661
141CDK11A0.09327290
142BRSK10.09268123
143CSF1R0.07760980
144CDK140.07072650
145PKN10.06230221
146CSNK2A10.06118058
147WNK30.05652005
148RPS6KA10.05477767
149PRKCD0.04864668
150PRKACG0.04723557
151GSK3B0.04421126
152YES10.03154981
153PRKG10.02682332
154CAMK2A0.02416822
155MAPK80.01744054
156CDK20.01097498
157STK100.00989594
158PRKCA0.00773105
159PRKCB0.00670899
160CDK10.00588670
161EGFR0.00408336
162EPHB10.00131620
163PIM10.00048962
164ZAP70-0.0373611
165RPS6KA3-0.0305176
166AURKA-0.0297351
167MAP3K1-0.0280661
168PRKACA-0.0274559
169CDK6-0.0265022
170CDK4-0.0234862
171GSK3A-0.0218723
172MAP3K5-0.0195830
173MAP3K3-0.0186516
174STK11-0.0093992
175CDK12-0.0076231
176CSNK2A2-0.0072322
177CSNK1D-0.0008178

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034104.97066694
2DNA replication_Homo sapiens_hsa030304.56633034
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.45612649
4Fatty acid biosynthesis_Homo sapiens_hsa000614.24552883
5Vitamin B6 metabolism_Homo sapiens_hsa007503.45438564
6Pyruvate metabolism_Homo sapiens_hsa006203.42921145
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.13448372
8Mismatch repair_Homo sapiens_hsa034303.10073677
9Linoleic acid metabolism_Homo sapiens_hsa005913.04754081
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.62093623
11Glucagon signaling pathway_Homo sapiens_hsa049222.61830068
12Propanoate metabolism_Homo sapiens_hsa006402.55579310
13Primary immunodeficiency_Homo sapiens_hsa053402.49930339
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.49387143
15Ribosome_Homo sapiens_hsa030102.39520915
16Basal transcription factors_Homo sapiens_hsa030222.34954316
17Homologous recombination_Homo sapiens_hsa034402.30442438
18Selenocompound metabolism_Homo sapiens_hsa004502.27043087
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20590895
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.19546900
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18455579
22Fatty acid elongation_Homo sapiens_hsa000622.13161263
23Oxidative phosphorylation_Homo sapiens_hsa001901.99778179
24Olfactory transduction_Homo sapiens_hsa047401.97426614
25Glycerolipid metabolism_Homo sapiens_hsa005611.85053662
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.82419439
27Nucleotide excision repair_Homo sapiens_hsa034201.78265229
28Parkinsons disease_Homo sapiens_hsa050121.75986811
29Asthma_Homo sapiens_hsa053101.75865105
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.72260644
31Oocyte meiosis_Homo sapiens_hsa041141.71156917
32Pentose phosphate pathway_Homo sapiens_hsa000301.71129444
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.70788834
34PPAR signaling pathway_Homo sapiens_hsa033201.67855813
35Non-homologous end-joining_Homo sapiens_hsa034501.67586203
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.65239253
37Peroxisome_Homo sapiens_hsa041461.61392171
38Fructose and mannose metabolism_Homo sapiens_hsa000511.58171683
39Amphetamine addiction_Homo sapiens_hsa050311.56955942
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51569005
41Mineral absorption_Homo sapiens_hsa049781.48979164
42Ether lipid metabolism_Homo sapiens_hsa005651.44969170
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44300614
44Fat digestion and absorption_Homo sapiens_hsa049751.43296539
45Dorso-ventral axis formation_Homo sapiens_hsa043201.40780685
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38677351
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32886086
48Carbon metabolism_Homo sapiens_hsa012001.31227059
49Cardiac muscle contraction_Homo sapiens_hsa042601.30069512
50Antigen processing and presentation_Homo sapiens_hsa046121.19974810
51Phototransduction_Homo sapiens_hsa047441.19610988
52Allograft rejection_Homo sapiens_hsa053301.18633345
53Autoimmune thyroid disease_Homo sapiens_hsa053201.18129075
54Fatty acid metabolism_Homo sapiens_hsa012121.16675388
55Fatty acid degradation_Homo sapiens_hsa000711.15960164
56Huntingtons disease_Homo sapiens_hsa050161.14470922
57Collecting duct acid secretion_Homo sapiens_hsa049661.14424393
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14380006
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14021950
60Fanconi anemia pathway_Homo sapiens_hsa034601.13693490
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.12781113
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.11548447
63Graft-versus-host disease_Homo sapiens_hsa053321.11104363
64Spliceosome_Homo sapiens_hsa030401.10272510
65Alzheimers disease_Homo sapiens_hsa050101.05321015
66Purine metabolism_Homo sapiens_hsa002301.05316407
67Insulin secretion_Homo sapiens_hsa049111.05133466
68Renin secretion_Homo sapiens_hsa049241.04759550
69Butanoate metabolism_Homo sapiens_hsa006501.04239151
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01724256
71RNA degradation_Homo sapiens_hsa030181.01418877
72Glutathione metabolism_Homo sapiens_hsa004800.99253296
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96897575
74Type I diabetes mellitus_Homo sapiens_hsa049400.95954222
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92859247
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89484242
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88593426
78Proteasome_Homo sapiens_hsa030500.87780256
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.85141310
80Tryptophan metabolism_Homo sapiens_hsa003800.84653185
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84561572
82mRNA surveillance pathway_Homo sapiens_hsa030150.83344563
83Hedgehog signaling pathway_Homo sapiens_hsa043400.81989845
84Arachidonic acid metabolism_Homo sapiens_hsa005900.78806369
85Thyroid hormone synthesis_Homo sapiens_hsa049180.77774765
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76991297
87Estrogen signaling pathway_Homo sapiens_hsa049150.75399958
88Hematopoietic cell lineage_Homo sapiens_hsa046400.75383074
89Legionellosis_Homo sapiens_hsa051340.75130603
90Biosynthesis of amino acids_Homo sapiens_hsa012300.74127206
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.73183090
92Long-term potentiation_Homo sapiens_hsa047200.73005448
93Chemical carcinogenesis_Homo sapiens_hsa052040.72559912
94Herpes simplex infection_Homo sapiens_hsa051680.72050189
95Sulfur metabolism_Homo sapiens_hsa009200.71265351
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.70276438
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69723213
98RNA transport_Homo sapiens_hsa030130.69171619
99Bile secretion_Homo sapiens_hsa049760.68476007
100Renin-angiotensin system_Homo sapiens_hsa046140.66994520
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66122817
102Platelet activation_Homo sapiens_hsa046110.62946297
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62742905
104Systemic lupus erythematosus_Homo sapiens_hsa053220.60390039
105Synaptic vesicle cycle_Homo sapiens_hsa047210.59743456
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.58872407
107Protein digestion and absorption_Homo sapiens_hsa049740.57648784
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57575991
109Pancreatic secretion_Homo sapiens_hsa049720.57506779
110Leishmaniasis_Homo sapiens_hsa051400.56381164
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56169934
112Rheumatoid arthritis_Homo sapiens_hsa053230.56034500
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53018428
114Calcium signaling pathway_Homo sapiens_hsa040200.52442251
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52040718
116Sulfur relay system_Homo sapiens_hsa041220.50755415
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50139437
118Salivary secretion_Homo sapiens_hsa049700.49869366
119Phenylalanine metabolism_Homo sapiens_hsa003600.49534846
120One carbon pool by folate_Homo sapiens_hsa006700.49412907
121Other glycan degradation_Homo sapiens_hsa005110.48685444
122Tyrosine metabolism_Homo sapiens_hsa003500.47881058
123Inositol phosphate metabolism_Homo sapiens_hsa005620.47433557
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.47120019
125ABC transporters_Homo sapiens_hsa020100.47099792
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45259048
127Viral myocarditis_Homo sapiens_hsa054160.42108141
128Metabolic pathways_Homo sapiens_hsa011000.41050289
129Endocytosis_Homo sapiens_hsa041440.41037189
130Galactose metabolism_Homo sapiens_hsa000520.40710137
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40547259
132RNA polymerase_Homo sapiens_hsa030200.39967068
133Gastric acid secretion_Homo sapiens_hsa049710.39528819
134AMPK signaling pathway_Homo sapiens_hsa041520.37798096
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37054780
136Shigellosis_Homo sapiens_hsa051310.36981321
137Circadian entrainment_Homo sapiens_hsa047130.36506176
138Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34518068
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34260696
140cAMP signaling pathway_Homo sapiens_hsa040240.33867623
141Alcoholism_Homo sapiens_hsa050340.33165585
142Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32950594
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32360260
144Pyrimidine metabolism_Homo sapiens_hsa002400.32356795
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31513169
146Nicotine addiction_Homo sapiens_hsa050330.31071431
147Staphylococcus aureus infection_Homo sapiens_hsa051500.31039211
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30103513
149Nitrogen metabolism_Homo sapiens_hsa009100.28757956
150Tuberculosis_Homo sapiens_hsa051520.27897592
151Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27351224
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26703474
153N-Glycan biosynthesis_Homo sapiens_hsa005100.26656695
154Lysosome_Homo sapiens_hsa041420.26562716
155beta-Alanine metabolism_Homo sapiens_hsa004100.26552413
156VEGF signaling pathway_Homo sapiens_hsa043700.26246173
157Cocaine addiction_Homo sapiens_hsa050300.25545042
158Taste transduction_Homo sapiens_hsa047420.24823732
159Vibrio cholerae infection_Homo sapiens_hsa051100.24746746
160Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14390966
161Type II diabetes mellitus_Homo sapiens_hsa049300.13416562
162HIF-1 signaling pathway_Homo sapiens_hsa040660.11782736
163Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.10580156
164B cell receptor signaling pathway_Homo sapiens_hsa046620.10206062
165Salmonella infection_Homo sapiens_hsa051320.08501541
166Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.07898930

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