LLGL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.58431577
2central nervous system myelination (GO:0022010)7.58431577
3ensheathment of neurons (GO:0007272)5.31233695
4axon ensheathment (GO:0008366)5.31233695
5myelination (GO:0042552)5.25750915
6lateral sprouting from an epithelium (GO:0060601)4.56839664
7convergent extension (GO:0060026)4.13974940
8apical protein localization (GO:0045176)4.07693512
9myelin maintenance (GO:0043217)3.99974482
10asymmetric protein localization (GO:0008105)3.88391300
11fatty acid elongation (GO:0030497)3.83260794
12astrocyte development (GO:0014002)3.79766574
13myelination in peripheral nervous system (GO:0022011)3.62431290
14peripheral nervous system axon ensheathment (GO:0032292)3.62431290
15lens fiber cell development (GO:0070307)3.60809630
16positive regulation of oligodendrocyte differentiation (GO:0048714)3.47703827
17cell migration in hindbrain (GO:0021535)3.42744840
18planar cell polarity pathway involved in neural tube closure (GO:0090179)3.40732686
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.38605494
20regulation of NFAT protein import into nucleus (GO:0051532)3.35083476
21polarized epithelial cell differentiation (GO:0030859)3.34519355
22postsynaptic membrane organization (GO:0001941)3.29853218
23oligodendrocyte differentiation (GO:0048709)3.28385628
24lung-associated mesenchyme development (GO:0060484)3.25141396
25creatine metabolic process (GO:0006600)3.23779107
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22947098
27regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.20578463
28pre-miRNA processing (GO:0031054)3.19237771
29adherens junction assembly (GO:0034333)3.17862263
30paraxial mesoderm development (GO:0048339)3.13758639
31axon extension involved in axon guidance (GO:0048846)3.13448207
32neuron projection extension involved in neuron projection guidance (GO:1902284)3.13448207
33G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.12764082
34layer formation in cerebral cortex (GO:0021819)3.10178882
35notochord development (GO:0030903)3.04448942
36regulation of collateral sprouting (GO:0048670)3.03402454
37DNA unwinding involved in DNA replication (GO:0006268)2.98870239
38cytoskeletal anchoring at plasma membrane (GO:0007016)2.96285391
39mesenchymal cell proliferation (GO:0010463)2.92426506
40neural tube development (GO:0021915)2.91686672
41limb bud formation (GO:0060174)2.89815360
42Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.88732006
43photoreceptor cell differentiation (GO:0046530)2.88454181
44eye photoreceptor cell differentiation (GO:0001754)2.88454181
45peptidyl-tyrosine autophosphorylation (GO:0038083)2.87297002
46nucleosome disassembly (GO:0006337)2.84902531
47protein-DNA complex disassembly (GO:0032986)2.84902531
48establishment of mitochondrion localization (GO:0051654)2.83043736
49protein retention in ER lumen (GO:0006621)2.83005537
50regulation of somitogenesis (GO:0014807)2.82507309
51long-chain fatty acid biosynthetic process (GO:0042759)2.81600973
52negative regulation of protein localization to cell surface (GO:2000009)2.81595055
53negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.81228023
54cell-cell junction maintenance (GO:0045217)2.79360475
55regulation of establishment of planar polarity (GO:0090175)2.78725117
56response to lipoprotein particle (GO:0055094)2.76559031
57cell communication by electrical coupling (GO:0010644)2.76531899
58establishment of apical/basal cell polarity (GO:0035089)2.76152696
59regulation of posttranscriptional gene silencing (GO:0060147)2.75373064
60regulation of gene silencing by miRNA (GO:0060964)2.75373064
61regulation of gene silencing by RNA (GO:0060966)2.75373064
62sodium ion export (GO:0071436)2.73909334
63cell-substrate adherens junction assembly (GO:0007045)2.73373644
64focal adhesion assembly (GO:0048041)2.73373644
65axon extension (GO:0048675)2.73367436
66axonal fasciculation (GO:0007413)2.72572236
67negative regulation of chondrocyte differentiation (GO:0032331)2.72189523
68locomotory exploration behavior (GO:0035641)2.70820289
69enteric nervous system development (GO:0048484)2.69183679
70neuroblast proliferation (GO:0007405)2.68347169
71establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.66032494
72presynaptic membrane assembly (GO:0097105)2.64413447
73positive regulation of glial cell differentiation (GO:0045687)2.64103103
74neuronal ion channel clustering (GO:0045161)2.64083597
75negative regulation of axonogenesis (GO:0050771)2.63546668
76establishment of planar polarity (GO:0001736)2.62981011
77establishment of tissue polarity (GO:0007164)2.62981011
78dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.62892537
79cerebellar granule cell differentiation (GO:0021707)2.62361276
80maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61443307
81Leydig cell differentiation (GO:0033327)2.61095158
82head development (GO:0060322)2.60568374
83regulation of mammary gland epithelial cell proliferation (GO:0033599)2.60321880
84neuromuscular process controlling balance (GO:0050885)2.60142957
85negative regulation of axon extension involved in axon guidance (GO:0048843)2.59054248
86establishment of mitotic spindle localization (GO:0040001)2.58654182
87* establishment or maintenance of bipolar cell polarity (GO:0061245)2.58077378
88* establishment or maintenance of apical/basal cell polarity (GO:0035088)2.58077378
89positive regulation of gliogenesis (GO:0014015)2.57875887
90non-canonical Wnt signaling pathway (GO:0035567)2.56173091
91presynaptic membrane organization (GO:0097090)2.56142751
92epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55256534
93negative regulation of axon extension (GO:0030517)2.54966867
94regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.54495927
95establishment of monopolar cell polarity (GO:0061162)2.54226144
96establishment or maintenance of monopolar cell polarity (GO:0061339)2.54226144
97neuron recognition (GO:0008038)2.54172686
98positive regulation of synapse maturation (GO:0090129)2.53742386
99cholesterol biosynthetic process (GO:0006695)2.53490497
100semaphorin-plexin signaling pathway (GO:0071526)2.53416072
101branching involved in salivary gland morphogenesis (GO:0060445)2.53402022
102cell fate commitment involved in formation of primary germ layer (GO:0060795)2.53296673
103amino acid import (GO:0043090)2.51684564
104regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51594942
105establishment of mitotic spindle orientation (GO:0000132)2.51558892
106L-amino acid import (GO:0043092)2.49831776
107regulation of oligodendrocyte differentiation (GO:0048713)2.49795358
108cochlea morphogenesis (GO:0090103)2.49348960
109negative regulation of neurotransmitter secretion (GO:0046929)2.47086836
110neuromuscular junction development (GO:0007528)2.45535486
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.45308178
112eye morphogenesis (GO:0048592)2.44928947
113cell-substrate junction assembly (GO:0007044)2.43921064
114neuron projection extension (GO:1990138)2.43796886
115apoptotic process involved in morphogenesis (GO:0060561)2.43499532
116astrocyte differentiation (GO:0048708)2.43112567
117mitotic nuclear envelope reassembly (GO:0007084)2.42252674
118nuclear envelope reassembly (GO:0031468)2.42252674
119somatic stem cell division (GO:0048103)2.41594753
120negative regulation of catenin import into nucleus (GO:0035414)2.41262825
121spinal cord development (GO:0021510)2.40858343
122cerebral cortex radially oriented cell migration (GO:0021799)2.40828510
123camera-type eye morphogenesis (GO:0048593)2.40270433
124regulation of axon extension involved in axon guidance (GO:0048841)2.39465438
125regulation of hippo signaling (GO:0035330)2.38348958
126cellular potassium ion homeostasis (GO:0030007)2.38177143
127protein complex localization (GO:0031503)2.36428551
128regulation of gliogenesis (GO:0014013)2.35544552
129lens morphogenesis in camera-type eye (GO:0002089)2.35540838
130positive regulation of neurological system process (GO:0031646)2.35153185
131heterochromatin organization (GO:0070828)2.34550548
132regulation of early endosome to late endosome transport (GO:2000641)2.34411459
133basement membrane organization (GO:0071711)2.34378099
134glial cell development (GO:0021782)2.33702212
135regulation of exit from mitosis (GO:0007096)2.32991286
136hippo signaling (GO:0035329)2.32769731
137bone trabecula formation (GO:0060346)2.32248812
138protein heterotrimerization (GO:0070208)2.32205707
139mitotic cytokinesis (GO:0000281)2.31290375
140hindlimb morphogenesis (GO:0035137)2.30948599
141glutamate secretion (GO:0014047)2.30923123
142substantia nigra development (GO:0021762)2.30501901
143DNA replication-dependent nucleosome assembly (GO:0006335)2.29862631
144DNA replication-dependent nucleosome organization (GO:0034723)2.29862631
145glial cell differentiation (GO:0010001)2.29714403
146regulation of short-term neuronal synaptic plasticity (GO:0048172)2.29639610
147negative regulation of smoothened signaling pathway (GO:0045879)2.29039093
148protein targeting to plasma membrane (GO:0072661)2.28505703
149lung lobe morphogenesis (GO:0060463)2.27756812
150mating behavior (GO:0007617)2.27536002
151outer ear morphogenesis (GO:0042473)2.27493417
152forebrain development (GO:0030900)2.27328562
153morphogenesis of an epithelial sheet (GO:0002011)2.26716223
154regulation of cardioblast differentiation (GO:0051890)2.26701226
155protein localization to endosome (GO:0036010)2.26554696
156cellular protein complex localization (GO:0034629)2.26327291
157negative regulation of neurotransmitter transport (GO:0051589)2.25373140
158regulation of catenin import into nucleus (GO:0035412)2.25330233
159negative regulation of axon guidance (GO:1902668)2.24755853
160peptidyl-arginine omega-N-methylation (GO:0035247)2.24251826
161developmental cell growth (GO:0048588)2.24107644
162establishment of nucleus localization (GO:0040023)2.23699406
163mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.23314919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human3.92819568
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.11271399
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.80097850
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.80097850
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.80097850
6E2F7_22180533_ChIP-Seq_HELA_Human2.73292601
7EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.67855953
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54988432
9ZFP281_18757296_ChIP-ChIP_E14_Mouse2.49181740
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.45997840
11* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.35405154
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.23230908
13LXR_22292898_ChIP-Seq_THP-1_Human2.21685545
14SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.15615852
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.15560797
16ZFP281_27345836_Chip-Seq_ESCs_Mouse2.11360767
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10816762
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05774503
19* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99552459
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98669873
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.98150161
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95055360
23KDM2B_26808549_Chip-Seq_DND41_Human1.83913268
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.82120345
25* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.79340513
26TCF3_18692474_ChIP-Seq_MEFs_Mouse1.74055363
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73555654
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.73472693
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.69523047
30NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.68623811
31EZH2_22144423_ChIP-Seq_EOC_Human1.67983354
32SOX2_16153702_ChIP-ChIP_HESCs_Human1.66673262
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66177584
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61852137
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.61558047
36KDM2B_26808549_Chip-Seq_K562_Human1.61165616
37TCF3_18692474_ChIP-Seq_MESCs_Mouse1.60771869
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58674653
39* RING1B_27294783_Chip-Seq_NPCs_Mouse1.55072038
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54662551
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51924395
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51753151
43POU5F1_16518401_ChIP-PET_MESCs_Mouse1.50940583
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50862507
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49820160
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48668031
47CLOCK_20551151_ChIP-Seq_293T_Human1.48621146
48KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.48314503
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47943089
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47736585
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47074659
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.45177280
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.44743988
54* EZH2_27294783_Chip-Seq_ESCs_Mouse1.44327941
55TCF7_22412390_ChIP-Seq_EML_Mouse1.43910840
56CTCF_27219007_Chip-Seq_Bcells_Human1.42829420
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.42606310
58ISL1_27105846_Chip-Seq_CPCs_Mouse1.42274329
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42200333
60TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.41838614
61* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40844225
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.40815921
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.40083291
64* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.39690824
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39010767
66TP53_22127205_ChIP-Seq_IMR90_Human1.38879708
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37653344
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36530884
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.36016937
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36009891
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33340407
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33155866
73EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33155866
74* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32944754
75* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31329355
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30845574
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.29568353
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29492026
79DROSHA_22980978_ChIP-Seq_HELA_Human1.29307117
80SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29249891
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28519249
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.28053615
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.26539718
84AR_21909140_ChIP-Seq_LNCAP_Human1.25933725
85MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25816170
86* SMC4_20622854_ChIP-Seq_HELA_Human1.24375177
87POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.23929439
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23820403
89MYC_22102868_ChIP-Seq_BL_Human1.23258259
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23221240
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.22263433
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22153648
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21699495
94FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21624026
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.20545913
96NANOG_21062744_ChIP-ChIP_HESCs_Human1.20110575
97RACK7_27058665_Chip-Seq_MCF-7_Human1.19590249
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19334014
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.19160743
100EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18975896
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18263560
102P68_20966046_ChIP-Seq_HELA_Human1.18241706
103JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16536753
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16295285
105TET1_21490601_ChIP-Seq_MESCs_Mouse1.16193868
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15829564
107E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15146278
108TRIM28_21343339_ChIP-Seq_HEK293_Human1.14997973
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14006907
110SOX2_18692474_ChIP-Seq_MESCs_Mouse1.13731619
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12603075
112MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11974852
113TP53_23651856_ChIP-Seq_MEFs_Mouse1.10946216
114E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10919566
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09570415
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09338872
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08416800
118RARB_27405468_Chip-Seq_BRAIN_Mouse1.08387292
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07985823
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07560416
121CREB1_26743006_Chip-Seq_LNCaP_Human1.06771898
122NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06389319
123NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05918742
124NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05077148
125STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05040514
126SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03686730
127HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03062488
128SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03047962
129FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03040877
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02694650
131CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02681496
132VDR_21846776_ChIP-Seq_THP-1_Human1.02481551
133EED_16625203_ChIP-ChIP_MESCs_Mouse1.02213914
134* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01464124
135KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99978903
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98925259
137TP63_19390658_ChIP-ChIP_HaCaT_Human0.98442114
138* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98261450
139HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98218826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.17418250
2MP0000537_abnormal_urethra_morphology2.99434111
3MP0010030_abnormal_orbit_morphology2.86602803
4MP0002653_abnormal_ependyma_morphology2.70706839
5MP0000920_abnormal_myelination2.55080230
6MP0005257_abnormal_intraocular_pressure2.38893967
7MP0001348_abnormal_lacrimal_gland2.18376452
8MP0000778_abnormal_nervous_system2.16657732
9MP0005623_abnormal_meninges_morphology2.14137358
10MP0003937_abnormal_limbs/digits/tail_de2.13997618
11MP0002254_reproductive_system_inflammat1.99286467
12MP0010678_abnormal_skin_adnexa1.95277837
13MP0003283_abnormal_digestive_organ1.91636257
14MP0000383_abnormal_hair_follicle1.90967741
15MP0000428_abnormal_craniofacial_morphol1.88790937
16MP0004885_abnormal_endolymph1.82922831
17MP0000579_abnormal_nail_morphology1.79275745
18MP0003950_abnormal_plasma_membrane1.77767309
19MP0003123_paternal_imprinting1.75613025
20MP0003385_abnormal_body_wall1.73852909
21MP0005423_abnormal_somatic_nervous1.70936684
22MP0000733_abnormal_muscle_development1.69887826
23MP0001293_anophthalmia1.68312328
24MP0000566_synostosis1.67491582
25MP0003938_abnormal_ear_development1.66224080
26MP0003122_maternal_imprinting1.63890794
27MP0003121_genomic_imprinting1.62062971
28MP0005409_darkened_coat_color1.60030501
29MP0009053_abnormal_anal_canal1.55638733
30MP0002089_abnormal_postnatal_growth/wei1.54904090
31MP0003634_abnormal_glial_cell1.53335113
32* MP0003861_abnormal_nervous_system1.52799281
33MP0000462_abnormal_digestive_system1.49348297
34MP0003755_abnormal_palate_morphology1.49242185
35MP0001485_abnormal_pinna_reflex1.49147381
36MP0003566_abnormal_cell_adhesion1.47489442
37MP0003119_abnormal_digestive_system1.46024377
38* MP0002085_abnormal_embryonic_tissue1.45649495
39MP0001849_ear_inflammation1.44452081
40MP0000049_abnormal_middle_ear1.43365780
41MP0009672_abnormal_birth_weight1.43243527
42MP0003690_abnormal_glial_cell1.42264388
43MP0000467_abnormal_esophagus_morphology1.41288904
44MP0004197_abnormal_fetal_growth/weight/1.40057592
45MP0002249_abnormal_larynx_morphology1.39791356
46MP0002084_abnormal_developmental_patter1.39559321
47MP0003115_abnormal_respiratory_system1.38978936
48MP0001299_abnormal_eye_distance/1.38359588
49MP0002932_abnormal_joint_morphology1.37763632
50MP0003942_abnormal_urinary_system1.37547063
51MP0003136_yellow_coat_color1.37295380
52MP0001958_emphysema1.36735526
53MP0002092_abnormal_eye_morphology1.36544461
54MP0000534_abnormal_ureter_morphology1.36030457
55MP0002233_abnormal_nose_morphology1.36027994
56MP0004742_abnormal_vestibular_system1.33679352
57MP0003635_abnormal_synaptic_transmissio1.32730423
58MP0002938_white_spotting1.32633960
59MP0004133_heterotaxia1.30518323
60MP0000762_abnormal_tongue_morphology1.30215005
61MP0001730_embryonic_growth_arrest1.29239909
62MP0000647_abnormal_sebaceous_gland1.29042157
63MP0003935_abnormal_craniofacial_develop1.25660453
64MP0004272_abnormal_basement_membrane1.24848864
65MP0009250_abnormal_appendicular_skeleto1.24676771
66MP0005171_absent_coat_pigmentation1.24532554
67MP0002111_abnormal_tail_morphology1.22369943
68MP0002697_abnormal_eye_size1.21623248
69MP0000432_abnormal_head_morphology1.19186418
70MP0002877_abnormal_melanocyte_morpholog1.17750907
71MP0002234_abnormal_pharynx_morphology1.17090681
72MP0004858_abnormal_nervous_system1.16671779
73MP0003632_abnormal_nervous_system1.16427798
74MP0008932_abnormal_embryonic_tissue1.15426244
75MP0003705_abnormal_hypodermis_morpholog1.14484994
76* MP0002116_abnormal_craniofacial_bone1.14166285
77MP0004134_abnormal_chest_morphology1.13520032
78MP0000955_abnormal_spinal_cord1.13401110
79MP0002063_abnormal_learning/memory/cond1.12043651
80MP0008438_abnormal_cutaneous_collagen1.10921170
81MP0003315_abnormal_perineum_morphology1.09233694
82MP0000751_myopathy1.08550243
83MP0003329_amyloid_beta_deposits1.07489796
84MP0008057_abnormal_DNA_replication1.05980857
85MP0003091_abnormal_cell_migration1.05207925
86MP0004811_abnormal_neuron_physiology1.03929443
87MP0005508_abnormal_skeleton_morphology1.02825452
88* MP0002152_abnormal_brain_morphology1.02760495
89MP0001697_abnormal_embryo_size1.01784643
90MP0005076_abnormal_cell_differentiation1.00687905
91MP0002282_abnormal_trachea_morphology1.00596833
92MP0005380_embryogenesis_phenotype0.99758994
93MP0001672_abnormal_embryogenesis/_devel0.99758994
94MP0009384_cardiac_valve_regurgitation0.98619469
95MP0009780_abnormal_chondrocyte_physiolo0.98372667
96MP0004957_abnormal_blastocyst_morpholog0.97950022
97MP0002114_abnormal_axial_skeleton0.97827841
98MP0008789_abnormal_olfactory_epithelium0.97232821
99MP0003279_aneurysm0.96628109
100MP0001340_abnormal_eyelid_morphology0.96572408
101MP0005499_abnormal_olfactory_system0.96180389
102MP0005394_taste/olfaction_phenotype0.96180389
103MP0003111_abnormal_nucleus_morphology0.94493151
104MP0000350_abnormal_cell_proliferation0.94154676
105MP0001529_abnormal_vocalization0.89296384
106MP0003984_embryonic_growth_retardation0.89283567
107MP0003890_abnormal_embryonic-extraembry0.88664590
108MP0002088_abnormal_embryonic_growth/wei0.88228746
109MP0004270_analgesia0.88198399
110MP0004185_abnormal_adipocyte_glucose0.88159909
111MP0003878_abnormal_ear_physiology0.87474587
112MP0005377_hearing/vestibular/ear_phenot0.87474587
113MP0003077_abnormal_cell_cycle0.86512589
114MP0002184_abnormal_innervation0.85705535
115* MP0002882_abnormal_neuron_morphology0.85703145
116MP0005503_abnormal_tendon_morphology0.85599125
117* MP0002081_perinatal_lethality0.85450667
118MP0001286_abnormal_eye_development0.84907045
119MP0004233_abnormal_muscle_weight0.84648178
120MP0008569_lethality_at_weaning0.84403730
121MP0005391_vision/eye_phenotype0.83876057
122MP0000003_abnormal_adipose_tissue0.83235048
123MP0008877_abnormal_DNA_methylation0.83062230
124MP0001984_abnormal_olfaction0.82645113
125MP0002925_abnormal_cardiovascular_devel0.82333344
126MP0009703_decreased_birth_body0.82241897
127MP0002734_abnormal_mechanical_nocicepti0.80709276
128MP0001346_abnormal_lacrimal_gland0.80668585
129MP0010368_abnormal_lymphatic_system0.80520437
130MP0001502_abnormal_circadian_rhythm0.78331560
131MP0005197_abnormal_uvea_morphology0.78208343
132MP0005275_abnormal_skin_tensile0.77658693
133MP0002080_prenatal_lethality0.77195922
134MP0002752_abnormal_somatic_nervous0.76757948
135MP0003453_abnormal_keratinocyte_physiol0.72226283
136MP0002896_abnormal_bone_mineralization0.72004323

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.74675836
2Degeneration of the lateral corticospinal tracts (HP:0002314)3.74675836
3Protrusio acetabuli (HP:0003179)3.47241704
4Esophageal atresia (HP:0002032)3.21732725
5Short 4th metacarpal (HP:0010044)3.11956438
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.11956438
7Shallow orbits (HP:0000586)3.11883602
8Abnormality of the corticospinal tract (HP:0002492)2.88509352
9Overriding aorta (HP:0002623)2.83681777
10Hypoplastic pelvis (HP:0008839)2.83478898
11Neurofibrillary tangles (HP:0002185)2.78226735
12Cerebral hypomyelination (HP:0006808)2.75684384
13Coronal craniosynostosis (HP:0004440)2.72512515
14Termporal pattern (HP:0011008)2.72399647
15Insidious onset (HP:0003587)2.72399647
16Obstructive sleep apnea (HP:0002870)2.70915193
17Alacrima (HP:0000522)2.56980492
18Abnormality of the 4th metacarpal (HP:0010012)2.53068662
19Renal duplication (HP:0000075)2.52525480
20Neonatal short-limb short stature (HP:0008921)2.51577640
21Cerebral inclusion bodies (HP:0100314)2.49334451
22Peripheral hypomyelination (HP:0007182)2.49265852
23Large earlobe (HP:0009748)2.44024008
24Genu recurvatum (HP:0002816)2.33691057
25Anteriorly placed anus (HP:0001545)2.33291660
26Atrophic scars (HP:0001075)2.27929856
27Sensory axonal neuropathy (HP:0003390)2.25083238
28Disproportionate tall stature (HP:0001519)2.24760171
29Partial duplication of the phalanx of hand (HP:0009999)2.24375785
30Elfin facies (HP:0004428)2.23577065
31Thin ribs (HP:0000883)2.22903175
32Arnold-Chiari malformation (HP:0002308)2.20862157
33Supernumerary ribs (HP:0005815)2.19649018
34Trigonocephaly (HP:0000243)2.18898687
35Partial duplication of thumb phalanx (HP:0009944)2.17593913
36Renovascular hypertension (HP:0100817)2.16288995
37Mitral regurgitation (HP:0001653)2.15861131
38Septo-optic dysplasia (HP:0100842)2.15091164
39High anterior hairline (HP:0009890)2.14958308
40Pointed chin (HP:0000307)2.14499688
41Spinal rigidity (HP:0003306)2.10697887
42Bowel diverticulosis (HP:0005222)2.09812550
43Supernumerary bones of the axial skeleton (HP:0009144)2.08328280
44Insomnia (HP:0100785)2.08300721
45Megalencephaly (HP:0001355)2.06960175
46Prominent occiput (HP:0000269)2.06051314
47Ulnar bowing (HP:0003031)2.05928361
48Abnormality of the salivary glands (HP:0010286)2.05349762
49Broad face (HP:0000283)2.05229886
50Premature skin wrinkling (HP:0100678)2.03524236
51Lower limb amyotrophy (HP:0007210)2.02220633
52Absent septum pellucidum (HP:0001331)2.01151296
53Cerebral aneurysm (HP:0004944)2.00591469
54Abnormality of dentin (HP:0010299)1.99949751
55Ankle contracture (HP:0006466)1.99073703
56Hyperacusis (HP:0010780)1.98989892
57Long palpebral fissure (HP:0000637)1.98562327
58Premature rupture of membranes (HP:0001788)1.98043819
59Abnormality of the labia minora (HP:0012880)1.97956792
60Abnormal auditory evoked potentials (HP:0006958)1.97240855
61Fragile skin (HP:0001030)1.96744428
62Decreased lacrimation (HP:0000633)1.96278176
63Vertebral arch anomaly (HP:0008438)1.95795253
64Wide anterior fontanel (HP:0000260)1.95316975
65Mitral valve prolapse (HP:0001634)1.95077150
66Cutaneous syndactyly (HP:0012725)1.93332084
67Rib fusion (HP:0000902)1.93177499
68Chin dimple (HP:0010751)1.92986388
69Split foot (HP:0001839)1.92478721
70Bilateral microphthalmos (HP:0007633)1.92019906
71Preaxial foot polydactyly (HP:0001841)1.91537625
72Broad metatarsal (HP:0001783)1.91507447
73Abnormality of the calcaneus (HP:0008364)1.91290112
74Broad distal phalanx of finger (HP:0009836)1.90396511
75Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.90158746
76Neoplasm of the oral cavity (HP:0100649)1.90129142
77Single umbilical artery (HP:0001195)1.89750446
78Abnormality of the fetal cardiovascular system (HP:0010948)1.89750446
79Abnormal umbilical cord blood vessels (HP:0011403)1.89750446
80Abnormality of the distal phalanx of the thumb (HP:0009617)1.89633206
81Stridor (HP:0010307)1.88341702
82Morphological abnormality of the inner ear (HP:0011390)1.88048710
83Broad phalanges of the hand (HP:0009768)1.88004616
84Cutaneous finger syndactyly (HP:0010554)1.87576571
85Biconcave vertebral bodies (HP:0004586)1.87449368
86Hypoventilation (HP:0002791)1.87414123
87Gastrointestinal atresia (HP:0002589)1.87389382
88Pseudobulbar signs (HP:0002200)1.85511641
89Increased nuchal translucency (HP:0010880)1.85020838
90Broad long bones (HP:0005622)1.84324894
91Vitreoretinal degeneration (HP:0000655)1.83552176
92Megalocornea (HP:0000485)1.82971681
93Aplasia involving bones of the upper limbs (HP:0009823)1.82925512
94Aplasia of the phalanges of the hand (HP:0009802)1.82925512
95Aplasia involving bones of the extremities (HP:0009825)1.82925512
96Spastic gait (HP:0002064)1.82245239
97Hyperextensible skin (HP:0000974)1.82016607
98Broad finger (HP:0001500)1.81967724
99Bowing of the arm (HP:0006488)1.81923809
100Bowed forearm bones (HP:0003956)1.81923809
101Broad thumb (HP:0011304)1.80620579
102Onion bulb formation (HP:0003383)1.80558225
103Myelomeningocele (HP:0002475)1.80495629
104Abnormal number of incisors (HP:0011064)1.80302931
105Abnormality of the aortic arch (HP:0012303)1.80085717
106Bladder diverticulum (HP:0000015)1.79351576
107Abnormality of the diencephalon (HP:0010662)1.78797679
108Turricephaly (HP:0000262)1.78578016
109Stenosis of the external auditory canal (HP:0000402)1.77357605
110Scapular winging (HP:0003691)1.76298197
111Precocious puberty (HP:0000826)1.76288537
112Humeroradial synostosis (HP:0003041)1.75721576
113Synostosis involving the elbow (HP:0003938)1.75721576
114Patellar dislocation (HP:0002999)1.75258169
115Parakeratosis (HP:0001036)1.75233447
116Bronchomalacia (HP:0002780)1.75078368
117Deviation of the hallux (HP:0010051)1.74787252
118Increased variability in muscle fiber diameter (HP:0003557)1.74715364
119Choanal stenosis (HP:0000452)1.74551045
120Ependymoma (HP:0002888)1.74524115
121Arterial tortuosity (HP:0005116)1.74157605
122Abnormality of the phalanges of the hallux (HP:0010057)1.73234128
123Vascular tortuosity (HP:0004948)1.72524854
124Selective tooth agenesis (HP:0001592)1.72329799
125Buphthalmos (HP:0000557)1.72264170
126Proximal placement of thumb (HP:0009623)1.72142686
127Abnormality of the parietal bone (HP:0002696)1.71979877
128Ankle clonus (HP:0011448)1.71765237
129Relative macrocephaly (HP:0004482)1.71390664
130Broad phalanx (HP:0006009)1.71293053
131Flat cornea (HP:0007720)1.70113861
132Abnormality of the septum pellucidum (HP:0007375)1.69879208
133Abnormality of chromosome segregation (HP:0002916)1.69563616
134Midface retrusion (HP:0011800)1.68476682
135Difficulty running (HP:0009046)1.68453352
136Oligodactyly (HP:0012165)1.67997230
137Hemivertebrae (HP:0002937)1.67050718
138Wormian bones (HP:0002645)1.66832725
139Abnormality of the antihelix (HP:0009738)1.66807489
140Abnormality of the middle phalanges of the toes (HP:0010183)1.66610237
141Distal upper limb amyotrophy (HP:0007149)1.66266827
142Upper limb amyotrophy (HP:0009129)1.66266827
143Supranuclear gaze palsy (HP:0000605)1.65733904
144Duplication of thumb phalanx (HP:0009942)1.65061505
145Syringomyelia (HP:0003396)1.63741281
146Spinal cord lesions (HP:0100561)1.63741281
147Tracheomalacia (HP:0002779)1.62311028
148Partial agenesis of the corpus callosum (HP:0001338)1.62236544
149Cervical subluxation (HP:0003308)1.60932248
150Spina bifida occulta (HP:0003298)1.60812200
151Anophthalmia (HP:0000528)1.60721071
152Abnormality of the phalanges of the 2nd finger (HP:0009541)1.60613593
153Hallux valgus (HP:0001822)1.60088915
154Distal lower limb amyotrophy (HP:0008944)1.59897520
155Abnormality of the astrocytes (HP:0100707)1.58768313
156Astrocytoma (HP:0009592)1.58768313
157Bowel incontinence (HP:0002607)1.58509397
158Difficulty climbing stairs (HP:0003551)1.58060893
159Vertebral clefting (HP:0008428)1.57854607
160Absent forearm bone (HP:0003953)1.56404785
161Aplasia involving forearm bones (HP:0009822)1.56404785
162Camptodactyly of toe (HP:0001836)1.55692518
163Blue sclerae (HP:0000592)1.53755654
164Hypercalcemia (HP:0003072)1.53601702
165Hammertoe (HP:0001765)1.53453726
166Soft skin (HP:0000977)1.53200402
167Asymmetry of the thorax (HP:0001555)1.52752482
168Morphological abnormality of the middle ear (HP:0008609)1.52704516
169Annular pancreas (HP:0001734)1.52180684

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.63035344
2ICK3.13793911
3TYRO32.96924988
4SMG12.92460821
5EPHB12.63043838
6CDK122.61525994
7RIPK12.45864904
8BCR2.31275492
9MET2.09547094
10MAP3K102.08004337
11OXSR12.02617118
12MARK11.96967585
13FGFR21.96067809
14PAK61.95440830
15UHMK11.89266622
16PASK1.87198659
17LIMK11.83864645
18EPHB21.71334232
19KSR11.65773439
20CDC71.64434087
21ROCK21.62929279
22CLK11.61142664
23FGFR41.61020707
24TESK21.59664572
25NTRK11.57633546
26PRKD31.47975461
27BUB11.46300871
28TRIB31.44919181
29CSNK1A1L1.42997022
30EEF2K1.40598898
31WNK11.32146413
32CSNK1G31.31121141
33PKN11.28764482
34MKNK11.28071041
35DDR21.26720594
36KSR21.25785032
37MAP3K131.24909359
38CAMKK11.24788833
39EPHA41.24352734
40BMX1.21389527
41PNCK1.18217768
42BRD41.18171257
43PDGFRA1.17034257
44CAMK1D1.13972087
45RPS6KA21.13437711
46PAK41.13390990
47CDK191.09929960
48ALK1.09656765
49PAK21.09010047
50LMTK21.03662022
51PBK1.03299684
52TTK1.02117797
53MTOR1.02109862
54CDK140.95598195
55NTRK30.94774291
56STK100.94711704
57ERBB20.94031286
58CSNK1G10.93425355
59CDK150.93347134
60PAK30.92892200
61LATS20.90844311
62FGFR10.90169589
63CDK180.90091914
64WNK40.88567499
65LATS10.87423621
66ARAF0.86041278
67CDK11A0.86022209
68CASK0.84696941
69FGR0.84468523
70PDGFRB0.83591850
71MAPKAPK50.83167203
72PRPF4B0.82914121
73SIK20.82442561
74PTK60.81728889
75MAP2K20.81495992
76MAP3K80.81110591
77PKN20.80869299
78NTRK20.80390298
79TTN0.79912402
80DYRK20.78464770
81DMPK0.78121513
82PTK20.77417532
83CDK70.77115464
84NEK20.76657160
85CSNK1G20.75274500
86CSNK1D0.74772277
87CHEK10.74598717
88PAK10.73216696
89SGK30.69137594
90BRAF0.67897314
91MELK0.66606510
92NEK60.66521250
93MARK20.65335618
94PRKD10.65094896
95RPS6KC10.63843471
96RPS6KL10.63843471
97RET0.61435002
98CAMK1G0.60069744
99LRRK20.59827114
100CDC42BPA0.55897275
101CDK10.55851797
102CDK40.54855800
103RPS6KB20.53559335
104DYRK1B0.53369390
105CSNK1E0.53074144
106SIK10.52854045
107ILK0.52496449
108CDK20.52101461
109TESK10.51860304
110PRKCH0.51574929
111ROCK10.51400406
112CDK50.50466599
113MAP3K90.49738683
114CHEK20.47986013
115STK40.47498693
116MOS0.47382897
117STK380.46126556
118STK110.45319501
119IRAK30.45159991
120MAP3K70.44666764
121MAPK100.44393353
122AKT20.44285825
123EPHA20.44193103
124RPS6KA60.43318250
125MAP3K110.41323623
126AURKA0.41137883
127PRKD20.40944464
128BRSK10.40505177
129CAMK2B0.40475510
130SGK4940.39831229
131SGK2230.39831229
132FYN0.37946770
133GSK3B0.37400288
134MINK10.35826289
135PHKG10.32795489
136PHKG20.32795489
137HIPK20.32515824
138RPS6KA10.32225148
139PDPK10.31427637

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.86304238
2Basal cell carcinoma_Homo sapiens_hsa052173.01051183
3Steroid biosynthesis_Homo sapiens_hsa001002.78910350
4Hedgehog signaling pathway_Homo sapiens_hsa043402.70722335
5Axon guidance_Homo sapiens_hsa043602.44618037
6* Hippo signaling pathway_Homo sapiens_hsa043902.26094994
7Renal cell carcinoma_Homo sapiens_hsa052112.06020212
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.99727648
9Notch signaling pathway_Homo sapiens_hsa043301.99151586
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86143410
11* Tight junction_Homo sapiens_hsa045301.80349764
12Spliceosome_Homo sapiens_hsa030401.75001865
13mRNA surveillance pathway_Homo sapiens_hsa030151.73447145
14MicroRNAs in cancer_Homo sapiens_hsa052061.70026084
15Ether lipid metabolism_Homo sapiens_hsa005651.68412815
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62029045
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.54155993
18Wnt signaling pathway_Homo sapiens_hsa043101.53744315
19Fatty acid elongation_Homo sapiens_hsa000621.53487467
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.48834651
21Dorso-ventral axis formation_Homo sapiens_hsa043201.45792921
22Cell cycle_Homo sapiens_hsa041101.44994662
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43675367
24Proteoglycans in cancer_Homo sapiens_hsa052051.38857567
25Prion diseases_Homo sapiens_hsa050201.33579036
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25035562
27TGF-beta signaling pathway_Homo sapiens_hsa043501.21977630
28Long-term potentiation_Homo sapiens_hsa047201.21619820
29Focal adhesion_Homo sapiens_hsa045101.21104056
30ECM-receptor interaction_Homo sapiens_hsa045121.20772143
31Chronic myeloid leukemia_Homo sapiens_hsa052201.20307329
32Melanogenesis_Homo sapiens_hsa049161.19891798
33Phospholipase D signaling pathway_Homo sapiens_hsa040721.18856429
34ErbB signaling pathway_Homo sapiens_hsa040121.18539353
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18297698
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16279294
37Oocyte meiosis_Homo sapiens_hsa041141.16213957
38Colorectal cancer_Homo sapiens_hsa052101.15924399
39Adherens junction_Homo sapiens_hsa045201.15421303
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12559009
41RNA transport_Homo sapiens_hsa030131.12216342
42Pathways in cancer_Homo sapiens_hsa052001.10691224
43DNA replication_Homo sapiens_hsa030301.07105056
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05873019
45Prostate cancer_Homo sapiens_hsa052151.05087521
46Gap junction_Homo sapiens_hsa045401.03048770
47Endocytosis_Homo sapiens_hsa041441.00707799
48Small cell lung cancer_Homo sapiens_hsa052220.99778421
49Sphingolipid signaling pathway_Homo sapiens_hsa040710.99190169
50Insulin signaling pathway_Homo sapiens_hsa049100.98208936
51Glioma_Homo sapiens_hsa052140.98208383
52Mismatch repair_Homo sapiens_hsa034300.97292742
53AMPK signaling pathway_Homo sapiens_hsa041520.97278895
54Bladder cancer_Homo sapiens_hsa052190.97220911
55Long-term depression_Homo sapiens_hsa047300.97003892
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94741657
57Synaptic vesicle cycle_Homo sapiens_hsa047210.94284203
58Endometrial cancer_Homo sapiens_hsa052130.93332349
59Circadian entrainment_Homo sapiens_hsa047130.92979221
60Biosynthesis of amino acids_Homo sapiens_hsa012300.92885663
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92679202
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92537520
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92193732
64Pancreatic cancer_Homo sapiens_hsa052120.89797235
65VEGF signaling pathway_Homo sapiens_hsa043700.89632291
66Non-small cell lung cancer_Homo sapiens_hsa052230.89307425
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87418897
68Cholinergic synapse_Homo sapiens_hsa047250.87070039
69Cocaine addiction_Homo sapiens_hsa050300.86469918
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86432416
71Vitamin B6 metabolism_Homo sapiens_hsa007500.84880309
72Rap1 signaling pathway_Homo sapiens_hsa040150.84146382
73HTLV-I infection_Homo sapiens_hsa051660.82370753
74Dopaminergic synapse_Homo sapiens_hsa047280.81773183
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80120732
76Ras signaling pathway_Homo sapiens_hsa040140.79580235
77Amoebiasis_Homo sapiens_hsa051460.79507644
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.78279452
79Inositol phosphate metabolism_Homo sapiens_hsa005620.78172602
80Protein digestion and absorption_Homo sapiens_hsa049740.77360716
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77183737
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77124745
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76919870
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76897659
85cAMP signaling pathway_Homo sapiens_hsa040240.76527242
86Choline metabolism in cancer_Homo sapiens_hsa052310.75902521
87Insulin secretion_Homo sapiens_hsa049110.75145763
88Base excision repair_Homo sapiens_hsa034100.74442546
89Oxytocin signaling pathway_Homo sapiens_hsa049210.73378538
90Estrogen signaling pathway_Homo sapiens_hsa049150.71688890
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71123639
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71106120
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70267177
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69787386
95mTOR signaling pathway_Homo sapiens_hsa041500.69353622
96Melanoma_Homo sapiens_hsa052180.69172126
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.67273955
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.66847881
99Viral carcinogenesis_Homo sapiens_hsa052030.66831647
100Thyroid hormone synthesis_Homo sapiens_hsa049180.66802379
101Dilated cardiomyopathy_Homo sapiens_hsa054140.66113386
102Viral myocarditis_Homo sapiens_hsa054160.65550573
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64294443
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64038081
105Acute myeloid leukemia_Homo sapiens_hsa052210.63090918
106Amphetamine addiction_Homo sapiens_hsa050310.62930029
107GABAergic synapse_Homo sapiens_hsa047270.62268448
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62261049
109Nicotine addiction_Homo sapiens_hsa050330.61671341
110Morphine addiction_Homo sapiens_hsa050320.61106517
111Alcoholism_Homo sapiens_hsa050340.60822049
112Vibrio cholerae infection_Homo sapiens_hsa051100.60420653
113Basal transcription factors_Homo sapiens_hsa030220.59899430
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59812284
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59121224
116Glutamatergic synapse_Homo sapiens_hsa047240.58614786
117Fatty acid biosynthesis_Homo sapiens_hsa000610.56810476
118MAPK signaling pathway_Homo sapiens_hsa040100.55488735
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52801574
120Sphingolipid metabolism_Homo sapiens_hsa006000.51890627
121Shigellosis_Homo sapiens_hsa051310.51518417
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51398812
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48731616
124GnRH signaling pathway_Homo sapiens_hsa049120.47674856
125Lysine degradation_Homo sapiens_hsa003100.47310873
126Nucleotide excision repair_Homo sapiens_hsa034200.45265445
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45188741
128T cell receptor signaling pathway_Homo sapiens_hsa046600.44299878
129Thyroid cancer_Homo sapiens_hsa052160.43520115
130Linoleic acid metabolism_Homo sapiens_hsa005910.43307462
131Ovarian steroidogenesis_Homo sapiens_hsa049130.42685686
132Arginine and proline metabolism_Homo sapiens_hsa003300.42091629
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.40547326
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39628548
135Gastric acid secretion_Homo sapiens_hsa049710.39018600
136Homologous recombination_Homo sapiens_hsa034400.37989834

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