LLGL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of Cdc42 GTPase activity (GO:0043089)5.10385500
2maintenance of gastrointestinal epithelium (GO:0030277)5.09821906
3intestinal epithelial cell development (GO:0060576)5.09237039
4regulation of gene silencing by RNA (GO:0060966)4.75382726
5regulation of posttranscriptional gene silencing (GO:0060147)4.75382726
6regulation of gene silencing by miRNA (GO:0060964)4.75382726
7regulation of hippo signaling (GO:0035330)4.63492553
8semaphorin-plexin signaling pathway (GO:0071526)4.50849625
9folic acid-containing compound biosynthetic process (GO:0009396)4.41990795
10lung epithelium development (GO:0060428)4.35958762
11calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.33932244
12intestinal cholesterol absorption (GO:0030299)4.11835915
13GDP-mannose metabolic process (GO:0019673)4.11460249
14positive regulation of keratinocyte differentiation (GO:0045618)4.06861490
15negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.06250930
16sulfur amino acid catabolic process (GO:0000098)4.04868679
17proline biosynthetic process (GO:0006561)4.04451007
18trophectodermal cell differentiation (GO:0001829)4.03419672
19establishment of apical/basal cell polarity (GO:0035089)3.99770576
20epithelial structure maintenance (GO:0010669)3.99252179
21regulation of female receptivity (GO:0045924)3.97035786
22phosphate ion homeostasis (GO:0055062)3.93915802
23trivalent inorganic anion homeostasis (GO:0072506)3.93915802
24regulation of water loss via skin (GO:0033561)3.93460550
25negative regulation of cell size (GO:0045792)3.91082751
26response to food (GO:0032094)3.90279372
27ear development (GO:0043583)3.88062539
28regulation of cholesterol homeostasis (GO:2000188)3.87167459
29regulation of extracellular matrix disassembly (GO:0010715)3.81368544
30multicellular organismal water homeostasis (GO:0050891)3.72579647
31intestinal absorption (GO:0050892)3.68264490
32primary alcohol catabolic process (GO:0034310)3.67776765
33cysteine metabolic process (GO:0006534)3.62437364
34regulation of fatty acid beta-oxidation (GO:0031998)3.61363278
35folic acid metabolic process (GO:0046655)3.61357022
36positive regulation of epidermal cell differentiation (GO:0045606)3.60235558
37female mating behavior (GO:0060180)3.50377660
38activation of Rac GTPase activity (GO:0032863)3.50107962
39COPI coating of Golgi vesicle (GO:0048205)3.49073427
40Golgi transport vesicle coating (GO:0048200)3.49073427
41proline metabolic process (GO:0006560)3.45838813
42ethanol metabolic process (GO:0006067)3.45471580
43striated muscle atrophy (GO:0014891)3.44326496
44vitamin transmembrane transport (GO:0035461)3.43837157
45interferon-gamma secretion (GO:0072643)3.42922884
46regulation of translational fidelity (GO:0006450)3.39214113
47branching involved in mammary gland duct morphogenesis (GO:0060444)3.36595493
48regulation of cholesterol biosynthetic process (GO:0045540)3.33478364
49peptidyl-tyrosine autophosphorylation (GO:0038083)3.31372861
50positive regulation of fatty acid beta-oxidation (GO:0032000)3.28887482
51glycine metabolic process (GO:0006544)3.28165131
52regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.28093276
53serine family amino acid catabolic process (GO:0009071)3.27740494
54anterior/posterior axis specification, embryo (GO:0008595)3.27282037
55amyloid precursor protein catabolic process (GO:0042987)3.26396509
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.23204050
57L-phenylalanine metabolic process (GO:0006558)3.23204050
58bundle of His cell to Purkinje myocyte communication (GO:0086069)3.22766068
59positive regulation of SMAD protein import into nucleus (GO:0060391)3.21515305
60pteridine-containing compound biosynthetic process (GO:0042559)3.20889737
61polarized epithelial cell differentiation (GO:0030859)3.18462644
62glucose 6-phosphate metabolic process (GO:0051156)3.17280757
63establishment of monopolar cell polarity (GO:0061162)3.16851571
64establishment or maintenance of monopolar cell polarity (GO:0061339)3.16851571
65regulation of cholesterol metabolic process (GO:0090181)3.16803165
66establishment of skin barrier (GO:0061436)3.14898794
67maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.11045120
68regulation of Cdc42 GTPase activity (GO:0043088)3.09053427
69phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.08798043
70cell-cell junction maintenance (GO:0045217)3.07970643
71glutathione biosynthetic process (GO:0006750)3.06126223
72L-alpha-amino acid transmembrane transport (GO:1902475)3.05132545
73lysine catabolic process (GO:0006554)3.04625254
74lysine metabolic process (GO:0006553)3.04625254
75columnar/cuboidal epithelial cell development (GO:0002066)3.04580342
764-hydroxyproline metabolic process (GO:0019471)3.03881805
77protein retention in ER lumen (GO:0006621)3.03224338
78retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.02945536
79serine family amino acid metabolic process (GO:0009069)3.02217053
80amyloid precursor protein metabolic process (GO:0042982)3.00497904
81nitric oxide biosynthetic process (GO:0006809)3.00422922
82paraxial mesoderm development (GO:0048339)3.00399737
83urea cycle (GO:0000050)2.99274520
84heterochromatin organization (GO:0070828)2.98480506
85establishment of epithelial cell polarity (GO:0090162)2.97976187
86negative regulation of viral release from host cell (GO:1902187)2.97697142
87O-glycan processing (GO:0016266)2.97433365
88homocysteine metabolic process (GO:0050667)2.97083421
89COPII vesicle coating (GO:0048208)2.96314349
90sulfate transmembrane transport (GO:1902358)2.96187212
91skeletal muscle adaptation (GO:0043501)2.95276496
92regulation of hydrogen peroxide metabolic process (GO:0010310)2.94908928
93flavonoid metabolic process (GO:0009812)2.93995964
94water homeostasis (GO:0030104)2.93880232
95positive regulation of histone deacetylation (GO:0031065)2.89485872
96erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.86466763
97L-phenylalanine catabolic process (GO:0006559)2.86466763
98mannose metabolic process (GO:0006013)2.85676135
99tetrahydrofolate metabolic process (GO:0046653)2.84919242
100regulation of viral release from host cell (GO:1902186)2.83092990
101urea metabolic process (GO:0019627)2.82944698
102negative regulation of T cell differentiation in thymus (GO:0033085)2.81991456
103muscle atrophy (GO:0014889)2.80345570
104epithelial cell-cell adhesion (GO:0090136)2.79030465
105hepatocyte apoptotic process (GO:0097284)2.78029074
106glyoxylate metabolic process (GO:0046487)2.76090932
107cell differentiation involved in embryonic placenta development (GO:0060706)2.74503269
108regulation of keratinocyte differentiation (GO:0045616)2.74013048
109epoxygenase P450 pathway (GO:0019373)2.73718257
110folic acid-containing compound metabolic process (GO:0006760)2.73478112
111fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.72776569
112histone H4-K12 acetylation (GO:0043983)2.71960576
113negative regulation of fatty acid biosynthetic process (GO:0045717)2.71777900
114maternal placenta development (GO:0001893)2.71267152
115insulin-like growth factor receptor signaling pathway (GO:0048009)2.70991165
116urate metabolic process (GO:0046415)2.70584119
117embryonic process involved in female pregnancy (GO:0060136)2.70319831
118nonribosomal peptide biosynthetic process (GO:0019184)2.69826942
119histone H2A monoubiquitination (GO:0035518)2.69822810
120negative regulation of protein tyrosine kinase activity (GO:0061099)2.68827791
121pre-miRNA processing (GO:0031054)2.67252275
122serine family amino acid biosynthetic process (GO:0009070)2.66335003
123cell junction maintenance (GO:0034331)2.65131298
124positive regulation of cellular amine metabolic process (GO:0033240)2.65073489
125glucocorticoid biosynthetic process (GO:0006704)2.64697073
126activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.63930145
127nucleobase biosynthetic process (GO:0046112)2.63839150
128formation of translation preinitiation complex (GO:0001731)2.63730695
129vitamin transport (GO:0051180)2.63372351
130regulation of ruffle assembly (GO:1900027)2.62933911
131regulation of SMAD protein import into nucleus (GO:0060390)2.60567354
132endothelial cell chemotaxis (GO:0035767)2.60499046
133L-ascorbic acid metabolic process (GO:0019852)2.58893815
134negative regulation of fatty acid transport (GO:2000192)2.58362828
135myelin maintenance (GO:0043217)2.58269049
136cellular modified amino acid catabolic process (GO:0042219)2.57164429
137positive regulation of nuclease activity (GO:0032075)2.56939019
138regulation of interleukin-13 production (GO:0032656)2.56029184
139UDP-N-acetylglucosamine metabolic process (GO:0006047)2.55336740
140stress granule assembly (GO:0034063)2.54508990
141regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.52502913
142nuclear pore organization (GO:0006999)2.51860401
143renal filtration (GO:0097205)2.51839544
144positive regulation of lipid catabolic process (GO:0050996)2.51364323
145phospholipid efflux (GO:0033700)2.51303877
146receptor catabolic process (GO:0032801)2.49402365
147atrioventricular valve morphogenesis (GO:0003181)2.49103100
148modified amino acid transport (GO:0072337)2.49043051
149apoptotic process involved in morphogenesis (GO:0060561)2.47850084
150regulation of bile acid biosynthetic process (GO:0070857)2.46541464
151embryonic placenta development (GO:0001892)2.46509283
152purine nucleobase biosynthetic process (GO:0009113)2.45930111
153drug transmembrane transport (GO:0006855)2.45440985
154drug catabolic process (GO:0042737)2.42451211
155hormone catabolic process (GO:0042447)2.41028075
156glutamine family amino acid biosynthetic process (GO:0009084)2.40507883
157regulation of nuclease activity (GO:0032069)2.40441610
158pteridine-containing compound metabolic process (GO:0042558)2.40411794
159tricarboxylic acid metabolic process (GO:0072350)2.39132920
160mitotic nuclear envelope disassembly (GO:0007077)2.39039142
161mitochondrial DNA metabolic process (GO:0032042)2.38878269
162negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.36187778
163DNA replication-dependent nucleosome organization (GO:0034723)2.35966982
164DNA replication-dependent nucleosome assembly (GO:0006335)2.35966982
165nucleotide salvage (GO:0043173)2.33920568
166phosphate ion transport (GO:0006817)2.33704737
167one-carbon metabolic process (GO:0006730)2.33333381
168regulation of gene silencing (GO:0060968)2.33044150
169nuclear pore complex assembly (GO:0051292)2.31150803
170desmosome organization (GO:0002934)2.31115980
171aromatic amino acid family catabolic process (GO:0009074)2.30606157
172somatic hypermutation of immunoglobulin genes (GO:0016446)2.30525736
173somatic diversification of immune receptors via somatic mutation (GO:0002566)2.30525736
174tight junction assembly (GO:0070830)2.29764686
175pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.29742917
176UMP biosynthetic process (GO:0006222)2.29742917
177pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.29742917
178UMP metabolic process (GO:0046049)2.29742917
179phosphate ion transmembrane transport (GO:0035435)2.28609297
180determination of adult lifespan (GO:0008340)2.27951120

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.30861941
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.09773578
3E2F7_22180533_ChIP-Seq_HELA_Human3.08944591
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.94450156
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.94450156
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.94450156
7* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.91323667
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.74782849
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.67153618
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.52549641
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.50163932
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.48353363
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.39470490
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.33125913
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.23851368
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.22510913
17STAT3_1855785_ChIP-Seq_MESCs_Mouse2.18683433
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17363479
19TCF3_18692474_ChIP-Seq_MEFs_Mouse2.14631520
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.03082961
21NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.00656131
22NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92492680
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92377208
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.91855425
25ZNF263_19887448_ChIP-Seq_K562_Human1.90247232
26KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.89337862
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88703753
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86998201
29* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86446753
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84692473
31P68_20966046_ChIP-Seq_HELA_Human1.83321699
32* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.83094620
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82403076
34LXR_22158963_ChIP-Seq_LIVER_Mouse1.82166485
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.80349554
36SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.78497484
37SMC4_20622854_ChIP-Seq_HELA_Human1.78090095
38TCF3_18692474_ChIP-Seq_MESCs_Mouse1.77010127
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.73320150
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.73183364
41* TCF7_22412390_ChIP-Seq_EML_Mouse1.69163956
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67255031
43VDR_21846776_ChIP-Seq_THP-1_Human1.64555731
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64162282
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62387141
46* CREB1_26743006_Chip-Seq_LNCaP_Human1.62120556
47AR_21909140_ChIP-Seq_LNCAP_Human1.60970734
48MYC_22102868_ChIP-Seq_BL_Human1.58357768
49* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56458341
50KDM2B_26808549_Chip-Seq_K562_Human1.55049317
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52574862
52SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.50322801
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49884187
54GATA6_25053715_ChIP-Seq_YYC3_Human1.49488403
55KDM2B_26808549_Chip-Seq_DND41_Human1.49008095
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.47536632
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44901940
58* ATF3_27146783_Chip-Seq_COLON_Human1.44363123
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43818013
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43084973
61RACK7_27058665_Chip-Seq_MCF-7_Human1.42927902
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42265091
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41978814
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.40666442
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38982987
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.38567420
67BCOR_27268052_Chip-Seq_Bcells_Human1.37538003
68SOX2_18692474_ChIP-Seq_MEFs_Mouse1.37312350
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37250745
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36073733
71CTCF_27219007_Chip-Seq_Bcells_Human1.36053056
72GATA3_24758297_ChIP-Seq_MCF-7_Human1.35954404
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35414956
74* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34858572
75* KLF5_25053715_ChIP-Seq_YYC3_Human1.34796667
76EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34279100
77POU5F1_16518401_ChIP-PET_MESCs_Mouse1.34072326
78RARB_24833708_ChIP-Seq_LIVER_Mouse1.33641066
79* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.33164675
80OCT4_18692474_ChIP-Seq_MEFs_Mouse1.33050316
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32836234
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30845520
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30638586
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30571229
85FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.30558312
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30502053
87CLOCK_20551151_ChIP-Seq_293T_Human1.29095485
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29040778
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.28715717
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28518054
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.27750786
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27734875
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27625733
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26597309
95NANOG_21062744_ChIP-ChIP_HESCs_Human1.25379717
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25025585
97* TP63_22573176_ChIP-Seq_HFKS_Human1.25001957
98SOX2_18692474_ChIP-Seq_MESCs_Mouse1.23819856
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23240314
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.21690085
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21653452
102BCL6_27268052_Chip-Seq_Bcells_Human1.21582154
103NANOG_18692474_ChIP-Seq_MEFs_Mouse1.21475407
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21359875
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20786024
106TP53_22127205_ChIP-Seq_IMR90_Human1.20287348
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19631501
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19209868
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18692159
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18254319
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16062286
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15651888
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15175045
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15116209
115PHF8_20622854_ChIP-Seq_HELA_Human1.14985227
116EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14581597
117GATA4_25053715_ChIP-Seq_YYC3_Human1.13726179
118KDM5A_27292631_Chip-Seq_BREAST_Human1.13047381
119SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13022243
120KAP1_27257070_Chip-Seq_ESCs_Mouse1.12631361
121* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.12565235
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12378600
123* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11676852
124* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.11220934
125E2F1_20622854_ChIP-Seq_HELA_Human1.10337185
126MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09591800
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08038771
128RARA_24833708_ChIP-Seq_LIVER_Mouse1.07519288
129EGR1_19374776_ChIP-ChIP_THP-1_Human1.06484977
130CTCF_26484167_Chip-Seq_Bcells_Mouse1.06463436
131SOX2_20726797_ChIP-Seq_SW620_Human1.05481427
132LXR_22292898_ChIP-Seq_THP-1_Human1.04769979
133EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04163600
134XRN2_22483619_ChIP-Seq_HELA_Human1.04099003
135AHR_22903824_ChIP-Seq_MCF-7_Human1.03883137
136DROSHA_22980978_ChIP-Seq_HELA_Human1.03416873
137CDX2_20551321_ChIP-Seq_CACO-2_Human1.03162668
138MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02049687
139CHD1_26751641_Chip-Seq_LNCaP_Human1.00785248
140CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00104091
141E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99141043
142KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97449786
143SA1_27219007_Chip-Seq_Bcells_Human0.97080837
144TET1_21490601_ChIP-Seq_MESCs_Mouse0.97077127
145TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96667874
146CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95913841
147* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95723792
148NCOR1_26117541_ChIP-Seq_K562_Human0.95529762
149STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95350386
150* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93992108
151ELF1_20517297_ChIP-Seq_JURKAT_Human0.93980637
152MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93893816
153TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93228878
154ELK3_25401928_ChIP-Seq_HUVEC_Human0.92971894
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.92943970
156* RUNX1_27514584_Chip-Seq_MCF-7_Human0.92662530
157JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92606249
158GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92439749
159ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92054794
160ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90126824
161E2F1_21310950_ChIP-Seq_MCF-7_Human0.88693367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.13714281
2MP0004264_abnormal_extraembryonic_tissu3.88228111
3MP0005360_urolithiasis3.47163529
4MP0002139_abnormal_hepatobiliary_system3.23019794
5MP0003806_abnormal_nucleotide_metabolis3.01366954
6MP0005365_abnormal_bile_salt2.91016942
7MP0005085_abnormal_gallbladder_physiolo2.69706360
8MP0010352_gastrointestinal_tract_polyps2.61586513
9MP0003705_abnormal_hypodermis_morpholog2.60403156
10MP0000566_synostosis2.59086817
11MP0003283_abnormal_digestive_organ2.44262817
12MP0005058_abnormal_lysosome_morphology2.33797353
13MP0003693_abnormal_embryo_hatching2.27688161
14MP0001873_stomach_inflammation2.24238215
15MP0001666_abnormal_nutrient_absorption2.23933612
16MP0004957_abnormal_blastocyst_morpholog2.22110508
17MP0003252_abnormal_bile_duct2.10121227
18MP0000383_abnormal_hair_follicle2.06625756
19MP0009780_abnormal_chondrocyte_physiolo2.05121359
20MP0009840_abnormal_foam_cell2.04097752
21MP0002249_abnormal_larynx_morphology2.00958125
22MP0002653_abnormal_ependyma_morphology1.96622727
23MP0005409_darkened_coat_color1.94615352
24MP0003183_abnormal_peptide_metabolism1.89267610
25MP0004381_abnormal_hair_follicle1.83538599
26MP0002796_impaired_skin_barrier1.82962244
27MP0004019_abnormal_vitamin_homeostasis1.82909384
28MP0004782_abnormal_surfactant_physiolog1.82192423
29MP0003119_abnormal_digestive_system1.71183780
30MP0002138_abnormal_hepatobiliary_system1.70398995
31MP0003866_abnormal_defecation1.67791835
32MP0001664_abnormal_digestion1.64377346
33MP0008875_abnormal_xenobiotic_pharmacok1.62789291
34MP0004858_abnormal_nervous_system1.59992785
35MP0005083_abnormal_biliary_tract1.57072667
36MP0001765_abnormal_ion_homeostasis1.55686015
37MP0002089_abnormal_postnatal_growth/wei1.53504084
38MP0003172_abnormal_lysosome_physiology1.52551767
39MP0005332_abnormal_amino_acid1.52373342
40MP0003566_abnormal_cell_adhesion1.52357690
41MP0004043_abnormal_pH_regulation1.51108224
42MP0005076_abnormal_cell_differentiation1.49745101
43MP0009643_abnormal_urine_homeostasis1.49658722
44MP0001730_embryonic_growth_arrest1.49477426
45MP0000537_abnormal_urethra_morphology1.46260971
46MP0001849_ear_inflammation1.43575685
47MP0000462_abnormal_digestive_system1.43411236
48MP0008872_abnormal_physiological_respon1.42829444
49MP0000579_abnormal_nail_morphology1.42506959
50MP0003941_abnormal_skin_development1.40272620
51MP0002086_abnormal_extraembryonic_tissu1.40268267
52MP0008260_abnormal_autophagy1.38604050
53MP0005220_abnormal_exocrine_pancreas1.36386008
54MP0003111_abnormal_nucleus_morphology1.35127516
55MP0002254_reproductive_system_inflammat1.34943216
56MP0001672_abnormal_embryogenesis/_devel1.34434363
57MP0005380_embryogenesis_phenotype1.34434363
58MP0003879_abnormal_hair_cell1.34133445
59MP0010155_abnormal_intestine_physiology1.33070353
60MP0002877_abnormal_melanocyte_morpholog1.32492100
61MP0002084_abnormal_developmental_patter1.29158946
62MP0003890_abnormal_embryonic-extraembry1.29080438
63MP0005501_abnormal_skin_physiology1.25534871
64MP0003453_abnormal_keratinocyte_physiol1.22805223
65MP0003984_embryonic_growth_retardation1.21337395
66MP0002088_abnormal_embryonic_growth/wei1.20892529
67MP0004133_heterotaxia1.20675932
68MP0000003_abnormal_adipose_tissue1.19135214
69MP0008057_abnormal_DNA_replication1.18806364
70MP0002085_abnormal_embryonic_tissue1.18156382
71MP0001697_abnormal_embryo_size1.17762241
72MP0003195_calcinosis1.17104215
73MP0003077_abnormal_cell_cycle1.16671577
74MP0002132_abnormal_respiratory_system1.16588592
75MP0010329_abnormal_lipoprotein_level1.15872308
76MP0004197_abnormal_fetal_growth/weight/1.14181901
77MP0004185_abnormal_adipocyte_glucose1.12705635
78MP0000538_abnormal_urinary_bladder1.11958896
79MP0010030_abnormal_orbit_morphology1.11549004
80MP0000609_abnormal_liver_physiology1.11282815
81MP0003878_abnormal_ear_physiology1.10274130
82MP0005377_hearing/vestibular/ear_phenot1.10274130
83MP0000490_abnormal_crypts_of1.07708693
84MP0004947_skin_inflammation1.05848093
85MP0000350_abnormal_cell_proliferation1.04207946
86MP0000678_abnormal_parathyroid_gland1.03818827
87MP0000627_abnormal_mammary_gland1.01978682
88MP0000477_abnormal_intestine_morphology1.01143229
89MP0005023_abnormal_wound_healing0.99899092
90MP0002080_prenatal_lethality0.99432747
91MP0009931_abnormal_skin_appearance0.96968748
92MP0002166_altered_tumor_susceptibility0.96042947
93MP0005636_abnormal_mineral_homeostasis0.93543212
94MP0001756_abnormal_urination0.93287461
95MP0002909_abnormal_adrenal_gland0.93275878
96MP0009053_abnormal_anal_canal0.92611589
97MP0003718_maternal_effect0.92316478
98MP0002098_abnormal_vibrissa_morphology0.91747557
99MP0005319_abnormal_enzyme/_coenzyme0.90875155
100MP0010771_integument_phenotype0.90559255
101MP0010094_abnormal_chromosome_stability0.90058423
102MP0003123_paternal_imprinting0.89272150
103MP0002060_abnormal_skin_morphology0.87826317
104MP0001881_abnormal_mammary_gland0.87074292
105MP0005375_adipose_tissue_phenotype0.86935461
106MP0003638_abnormal_response/metabolism_0.85806521
107MP0000858_altered_metastatic_potential0.85447181
108MP0000013_abnormal_adipose_tissue0.83131593
109MP0001944_abnormal_pancreas_morphology0.82430782
110MP0003191_abnormal_cellular_cholesterol0.82118486
111MP0003938_abnormal_ear_development0.81582086
112MP0005381_digestive/alimentary_phenotyp0.81463113
113MP0005670_abnormal_white_adipose0.80632038
114MP0005266_abnormal_metabolism0.80443954
115MP0009384_cardiac_valve_regurgitation0.80326590
116MP0003868_abnormal_feces_composition0.79194266
117MP0001293_anophthalmia0.79114269
118MP0010678_abnormal_skin_adnexa0.79074607
119MP0000598_abnormal_liver_morphology0.78484335
120MP0000427_abnormal_hair_cycle0.78467756
121MP0003567_abnormal_fetal_cardiomyocyte0.78447563
122MP0001216_abnormal_epidermal_layer0.78431181
123MP0002136_abnormal_kidney_physiology0.78026821
124MP0000467_abnormal_esophagus_morphology0.75654553
125MP0010307_abnormal_tumor_latency0.74865194
126MP0003300_gastrointestinal_ulcer0.74101443
127MP0002118_abnormal_lipid_homeostasis0.73066285
128MP0002111_abnormal_tail_morphology0.71458821
129MP0001663_abnormal_digestive_system0.71008740
130MP0002269_muscular_atrophy0.70548438
131MP0000367_abnormal_coat/_hair0.69889706
132MP0000470_abnormal_stomach_morphology0.69452838
133MP0002822_catalepsy0.69246700
134MP0008932_abnormal_embryonic_tissue0.68189736
135MP0002928_abnormal_bile_duct0.68133249
136MP0009672_abnormal_birth_weight0.67780969
137MP0005451_abnormal_body_composition0.67663120
138MP0000613_abnormal_salivary_gland0.67161678
139MP0002697_abnormal_eye_size0.66549751
140MP0001764_abnormal_homeostasis0.65513314
141MP0000377_abnormal_hair_follicle0.65039864
142MP0002693_abnormal_pancreas_physiology0.64285742
143MP0006072_abnormal_retinal_apoptosis0.64251075
144MP0000516_abnormal_urinary_system0.64150452
145MP0005367_renal/urinary_system_phenotyp0.64150452
146MP0002970_abnormal_white_adipose0.63909416
147MP0005666_abnormal_adipose_tissue0.63879728
148MP0003936_abnormal_reproductive_system0.63766677
149MP0003115_abnormal_respiratory_system0.62414957
150MP0002277_abnormal_respiratory_mucosa0.59857083
151MP0009379_abnormal_foot_pigmentation0.59462403

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)5.17114465
2Gout (HP:0001997)4.04660608
3Thin bony cortex (HP:0002753)3.97077996
4Hypoglycemic coma (HP:0001325)3.82675456
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.74240891
6Intrahepatic cholestasis (HP:0001406)3.67729479
7Hyperinsulinemic hypoglycemia (HP:0000825)3.62799459
8Lymphangioma (HP:0100764)3.58311460
9Hyperglycinuria (HP:0003108)3.56952467
10Ependymoma (HP:0002888)3.33862357
11Amelogenesis imperfecta (HP:0000705)3.31028356
12Right ventricular cardiomyopathy (HP:0011663)3.21068590
13Septate vagina (HP:0001153)3.17577028
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.15955296
15Malnutrition (HP:0004395)3.11920205
16Hemorrhage of the eye (HP:0011885)3.09169160
17Hypoglycemic seizures (HP:0002173)3.06022360
18Asymmetry of the thorax (HP:0001555)3.05252629
19Stridor (HP:0010307)3.04506746
20Broad face (HP:0000283)3.03400928
21Ketoacidosis (HP:0001993)2.93681365
22Abnormality of glutamine family amino acid metabolism (HP:0010902)2.92441426
23Bronchomalacia (HP:0002780)2.83501897
24Late onset (HP:0003584)2.81856954
25Decreased circulating renin level (HP:0003351)2.77461897
26Germ cell neoplasia (HP:0100728)2.76010749
27Hyperactive renin-angiotensin system (HP:0000841)2.74987203
28Pili torti (HP:0003777)2.74977287
29Abnormality of glycine metabolism (HP:0010895)2.72824974
30Abnormality of serine family amino acid metabolism (HP:0010894)2.72824974
31Visceral angiomatosis (HP:0100761)2.70440838
32Esophageal varix (HP:0002040)2.68704604
33Shawl scrotum (HP:0000049)2.68150969
34Abnormality of the pancreatic islet cells (HP:0006476)2.67093446
35Abnormality of endocrine pancreas physiology (HP:0012093)2.67093446
36Vertebral clefting (HP:0008428)2.65050529
37Hyperglycinemia (HP:0002154)2.64767686
38Hyperacusis (HP:0010780)2.64137107
39Short humerus (HP:0005792)2.61307469
40Hypobetalipoproteinemia (HP:0003563)2.57668579
41Xanthomatosis (HP:0000991)2.55358690
42Abnormality of renin-angiotensin system (HP:0000847)2.54560307
43Aplasia/hypoplasia of the humerus (HP:0006507)2.53365987
44Abnormality of purine metabolism (HP:0004352)2.53313899
45Cerebral aneurysm (HP:0004944)2.52107446
46Ketosis (HP:0001946)2.51610676
47Deformed sella turcica (HP:0002681)2.50656131
48Abnormality of sulfur amino acid metabolism (HP:0004339)2.50236971
49Biliary tract neoplasm (HP:0100574)2.50043330
50Cervical subluxation (HP:0003308)2.46079368
51Diaphragmatic weakness (HP:0009113)2.45940905
52Hyperammonemia (HP:0001987)2.45170702
53Hemangiomatosis (HP:0007461)2.44699496
54Increased purine levels (HP:0004368)2.43368071
55Hyperuricemia (HP:0002149)2.43368071
56Abnormality of nucleobase metabolism (HP:0010932)2.42552440
57Symptomatic seizures (HP:0011145)2.42518869
58Multiple enchondromatosis (HP:0005701)2.38600724
59Hyperglycemia (HP:0003074)2.38099113
60Pancreatic islet-cell hyperplasia (HP:0004510)2.36891109
61Metaphyseal cupping (HP:0003021)2.33521341
62Missing ribs (HP:0000921)2.31494852
63Spastic diplegia (HP:0001264)2.30699791
64Spinal cord compression (HP:0002176)2.29968593
65Abnormal biliary tract morphology (HP:0012440)2.29322115
66Abnormality of chloride homeostasis (HP:0011422)2.27574180
67Mucopolysacchariduria (HP:0008155)2.26866302
68Urinary glycosaminoglycan excretion (HP:0003541)2.26866302
69Distal lower limb muscle weakness (HP:0009053)2.26408798
70Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.26402949
71Flattened epiphyses (HP:0003071)2.23558474
72Hyperparathyroidism (HP:0000843)2.22075801
73Abnormality of pyrimidine metabolism (HP:0004353)2.21029524
74Rib fusion (HP:0000902)2.20472037
75Distal upper limb amyotrophy (HP:0007149)2.19910048
76Upper limb amyotrophy (HP:0009129)2.19910048
77Fat malabsorption (HP:0002630)2.19675078
78Abnormal vertebral ossification (HP:0100569)2.19036537
79Abdominal distention (HP:0003270)2.18061932
80Hypophosphatemia (HP:0002148)2.17189534
81Abnormality of the salivary glands (HP:0010286)2.15815155
82Concave nail (HP:0001598)2.14965488
83Focal segmental glomerulosclerosis (HP:0000097)2.14804760
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14161404
85Abnormality of polysaccharide metabolism (HP:0011012)2.14161404
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14161404
87Unilateral renal agenesis (HP:0000122)2.13800240
88Renal salt wasting (HP:0000127)2.13583686
89Ileus (HP:0002595)2.13218361
90Enlarged penis (HP:0000040)2.11115931
91Increased neuronal autofluorescent lipopigment (HP:0002074)2.10325439
92Abnormality of the astrocytes (HP:0100707)2.09456831
93Astrocytoma (HP:0009592)2.09456831
94Curly hair (HP:0002212)2.08224933
95Abnormal cartilage morphology (HP:0002763)2.04660204
96Flat acetabular roof (HP:0003180)2.04328554
97Insulin resistance (HP:0000855)2.03141200
98Lip pit (HP:0100267)2.01954210
99Seborrheic dermatitis (HP:0001051)2.00290177
100Alkalosis (HP:0001948)1.99875822
101Abnormality of the gastric mucosa (HP:0004295)1.99838838
102Proximal tubulopathy (HP:0000114)1.99057776
103Hand muscle atrophy (HP:0009130)1.98455444
104Chronic bronchitis (HP:0004469)1.98431990
105Breast carcinoma (HP:0003002)1.98040616
106Easy fatigability (HP:0003388)1.96907135
107Obstructive sleep apnea (HP:0002870)1.96270216
108Hypolipoproteinemia (HP:0010981)1.95069577
109Abnormal hair laboratory examination (HP:0003328)1.94988428
110Deep venous thrombosis (HP:0002625)1.94437752
111Abnormal enzyme/coenzyme activity (HP:0012379)1.94113090
112Abnormal pancreas size (HP:0012094)1.93392763
113Rhabdomyosarcoma (HP:0002859)1.93037050
114Distal lower limb amyotrophy (HP:0008944)1.92975582
115Abnormality of alkaline phosphatase activity (HP:0004379)1.91374261
116Abnormality of the intrinsic pathway (HP:0010989)1.87529595
117Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.86803593
118Vertebral hypoplasia (HP:0008417)1.86803593
119Growth hormone excess (HP:0000845)1.86409614
120Abnormality of small intestinal villus morphology (HP:0011472)1.86355985
121Villous atrophy (HP:0011473)1.86355985
122Hyperphosphatemia (HP:0002905)1.85761964
123Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84582608
124Selective tooth agenesis (HP:0001592)1.83963359
125Absent radius (HP:0003974)1.83629064
126Malignant gastrointestinal tract tumors (HP:0006749)1.82424037
127Gastrointestinal carcinoma (HP:0002672)1.82424037
128Advanced eruption of teeth (HP:0006288)1.82229242
129Bell-shaped thorax (HP:0001591)1.80445151
130Back pain (HP:0003418)1.80439091
131Pseudobulbar signs (HP:0002200)1.80011800
132Widely patent fontanelles and sutures (HP:0004492)1.79744537
133Irritability (HP:0000737)1.79742785
134Trismus (HP:0000211)1.79185273
135Protuberant abdomen (HP:0001538)1.79135078
136Nuclear cataract (HP:0100018)1.78941603
137Mildly elevated creatine phosphokinase (HP:0008180)1.78919218
138Dysostosis multiplex (HP:0000943)1.78867518
139Fused cervical vertebrae (HP:0002949)1.77504989
140Posterior subcapsular cataract (HP:0007787)1.77169691
141Hydroxyprolinuria (HP:0003080)1.77044992
142Abnormality of proline metabolism (HP:0010907)1.77044992
143Breast hypoplasia (HP:0003187)1.75637612
144Pterygium (HP:0001059)1.74953725
145Glomerulonephritis (HP:0000099)1.74697964
146Neoplasm of the oral cavity (HP:0100649)1.74494468
147Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.74217952
148Hyponatremia (HP:0002902)1.73545215
149Sparse lateral eyebrow (HP:0005338)1.72762723
150Nasal polyposis (HP:0100582)1.71944778
151Abnormality of the thoracic spine (HP:0100711)1.71778049
152Aplasia involving forearm bones (HP:0009822)1.71735235
153Absent forearm bone (HP:0003953)1.71735235
154Micronodular cirrhosis (HP:0001413)1.71621007
155Vascular calcification (HP:0004934)1.70858789
156Interstitial pulmonary disease (HP:0006530)1.70612305
157Uterine neoplasm (HP:0010784)1.70531737
158Congenital glaucoma (HP:0001087)1.70231824
159Woolly hair (HP:0002224)1.69787381
160Abnormal tarsal ossification (HP:0008369)1.69369183
161Hypotension (HP:0002615)1.69154732
162Neoplasm of striated muscle (HP:0009728)1.69037362
163Testicular neoplasm (HP:0010788)1.68628099
164Abnormality of the dental root (HP:0006486)1.68444531
165Taurodontia (HP:0000679)1.68444531
166Abnormality of permanent molar morphology (HP:0011071)1.68444531
167Increased cerebral lipofuscin (HP:0011813)1.68443981
168Renal tubular acidosis (HP:0001947)1.67586913
169Abnormality of the distal phalanges of the toes (HP:0010182)1.66361335
170Glomerulosclerosis (HP:0000096)1.66113097
171Abnormal hemoglobin (HP:0011902)1.66103614
172Neonatal death (HP:0003811)1.65460101
173Abnormality of the 1st metacarpal (HP:0010009)1.65202795
174Turricephaly (HP:0000262)1.65032111
175Generalized aminoaciduria (HP:0002909)1.64546062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.19828075
2CDK123.63215511
3SMG12.49989710
4RPS6KB22.45151328
5LATS12.37903098
6ERN12.28841636
7MAPK152.17732778
8STK38L2.17358867
9TTK2.05576920
10BCKDK2.03474369
11NME11.97726476
12NME21.96915068
13MAP3K101.92405766
14AKT31.86214657
15RIPK11.82662518
16MAP2K21.82458650
17MAPKAPK31.80998347
18TRIB31.76579778
19PASK1.73146481
20NEK11.72824685
21PKN21.72319571
22PIK3CA1.69392341
23WNK31.64885490
24ICK1.63930453
25NEK21.61225830
26MUSK1.57710150
27STK101.52858527
28FLT31.49600165
29MET1.49307867
30PTK21.48361910
31DDR21.44580642
32EEF2K1.39702160
33PAK41.37447055
34LMTK21.37044534
35PTK61.32710910
36CDK71.30722948
37MST41.27508932
38MAP2K61.26098681
39MTOR1.24348061
40IRAK31.16310719
41SCYL21.15963312
42MAP3K81.15901320
43PDGFRA1.14695114
44WEE11.14425536
45MAP3K31.13788376
46FGFR41.12420099
47FRK1.12145453
48NEK61.10856133
49WNK41.07877634
50INSRR1.06583219
51LATS21.05673805
52ERBB21.04994378
53TNK21.04717069
54BUB11.01314681
55GRK61.00563057
56SIK10.98350702
57TAOK30.97913414
58DYRK1B0.97723032
59BRD40.97441596
60MAP3K110.94235035
61RPS6KA20.92958195
62PDPK10.92789337
63STK390.91276725
64PLK10.91181698
65DYRK30.86726204
66AURKB0.86591942
67CDK40.85978618
68FGFR20.85105433
69ERBB40.84036366
70CHEK20.82792472
71TBK10.77436589
72TAOK10.76312787
73EPHB10.76041679
74CDK60.75611659
75MST1R0.74749384
76PLK40.73034398
77BMX0.72844185
78PRKG20.72599918
79MARK20.71670084
80SIK30.71652821
81FER0.71403844
82LRRK20.71371312
83CDC70.70979484
84STK30.70880803
85PIM10.70057186
86TYRO30.68704953
87RET0.68325733
88MAP3K20.64954425
89MAPK110.64818416
90RPS6KL10.62627174
91RPS6KC10.62627174
92MATK0.62340422
93CHEK10.61922075
94GSK3A0.60516628
95ILK0.60306371
96FGFR30.59508734
97CSK0.59173771
98AURKA0.58813926
99ALK0.57804866
100PRKD20.56801735
101AKT20.54927378
102MAP3K60.54009873
103MAP3K10.53014107
104RPS6KA60.52968980
105KSR20.50333721
106MAP4K10.50184014
107MAP3K70.50071591
108MELK0.49537984
109MAP2K30.49397557
110BRSK20.49395041
111HIPK20.49102132
112PRKAA10.48306189
113TESK20.48205099
114PRKD30.46297787
115MAPKAPK20.45914745
116CDK20.45004184
117CHUK0.44786566
118RPS6KA40.44507339
119STK380.43473209
120CDC42BPA0.43134233
121* PRKCI0.41996120
122CSNK1E0.41634670
123PDK10.41547354
124TTN0.41384280
125PAK20.39428526
126PRKAA20.38569302
127TESK10.37437226
128MAP2K10.37303388
129ATR0.36722591
130ATM0.35801322
131CSF1R0.35749198
132RPS6KA10.35327123
133IKBKE0.35117203
134MAPK80.32553224
135PRKD10.29864454
136CAMKK10.27086900
137PRKCZ0.24783379
138CSNK1A10.23004500
139CAMK2G0.22278281
140PRPF4B0.22004882
141DAPK10.21939517
142TYK20.21270885
143IKBKB0.21143261
144CAMK2D0.20711245
145TAOK20.19163999
146STK240.19058208
147FGFR10.18082884

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.82895650
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.50990025
3Folate biosynthesis_Homo sapiens_hsa007902.34502209
4Selenocompound metabolism_Homo sapiens_hsa004502.33284792
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26754874
6Fat digestion and absorption_Homo sapiens_hsa049752.18054853
7Nitrogen metabolism_Homo sapiens_hsa009102.16862236
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09033728
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06933084
10Tryptophan metabolism_Homo sapiens_hsa003802.01110642
11Arginine biosynthesis_Homo sapiens_hsa002201.98813837
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95965902
13One carbon pool by folate_Homo sapiens_hsa006701.92983460
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87797164
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79041004
16Sulfur metabolism_Homo sapiens_hsa009201.74178506
17Biosynthesis of amino acids_Homo sapiens_hsa012301.74155081
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.74062535
19Fatty acid degradation_Homo sapiens_hsa000711.63602805
20Sphingolipid metabolism_Homo sapiens_hsa006001.62493157
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59567875
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.54877117
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.53896301
24Fructose and mannose metabolism_Homo sapiens_hsa000511.52865818
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47909549
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46708072
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.46288888
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.43287947
29Carbon metabolism_Homo sapiens_hsa012001.41715620
30Lysine degradation_Homo sapiens_hsa003101.38799423
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38032349
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36971032
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35599563
34Hepatitis C_Homo sapiens_hsa051601.35584675
35Galactose metabolism_Homo sapiens_hsa000521.34843682
36Vitamin digestion and absorption_Homo sapiens_hsa049771.34123478
37Mismatch repair_Homo sapiens_hsa034301.32914178
38Arginine and proline metabolism_Homo sapiens_hsa003301.31225821
39Bile secretion_Homo sapiens_hsa049761.29933399
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29083416
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.26488816
42Histidine metabolism_Homo sapiens_hsa003401.23361813
43Endometrial cancer_Homo sapiens_hsa052131.19686835
44RNA transport_Homo sapiens_hsa030131.19045542
45Sulfur relay system_Homo sapiens_hsa041221.19010785
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18132749
47Acute myeloid leukemia_Homo sapiens_hsa052211.17026716
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13170324
49Butanoate metabolism_Homo sapiens_hsa006501.12481949
50Bladder cancer_Homo sapiens_hsa052191.11999482
51Pyruvate metabolism_Homo sapiens_hsa006201.10197975
52Insulin signaling pathway_Homo sapiens_hsa049101.10173312
53Glutathione metabolism_Homo sapiens_hsa004801.09430150
54VEGF signaling pathway_Homo sapiens_hsa043701.07205203
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02190754
56Choline metabolism in cancer_Homo sapiens_hsa052311.00864401
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99044594
58Starch and sucrose metabolism_Homo sapiens_hsa005000.97879883
59Peroxisome_Homo sapiens_hsa041460.97547144
60Propanoate metabolism_Homo sapiens_hsa006400.96068940
61Protein digestion and absorption_Homo sapiens_hsa049740.95925600
62beta-Alanine metabolism_Homo sapiens_hsa004100.94888921
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93443828
64Adherens junction_Homo sapiens_hsa045200.92701450
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91314278
66Fatty acid metabolism_Homo sapiens_hsa012120.90360592
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90140544
68Phenylalanine metabolism_Homo sapiens_hsa003600.89931960
69Pentose phosphate pathway_Homo sapiens_hsa000300.89759045
70DNA replication_Homo sapiens_hsa030300.89140971
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87762552
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87299993
73* Hippo signaling pathway_Homo sapiens_hsa043900.87118164
74Glycerolipid metabolism_Homo sapiens_hsa005610.86926741
75Chemical carcinogenesis_Homo sapiens_hsa052040.86641761
76* Tight junction_Homo sapiens_hsa045300.86258360
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86083195
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.85575680
79PPAR signaling pathway_Homo sapiens_hsa033200.83329552
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82452104
81Lysosome_Homo sapiens_hsa041420.78401062
82p53 signaling pathway_Homo sapiens_hsa041150.78174190
83ErbB signaling pathway_Homo sapiens_hsa040120.77403554
84Vibrio cholerae infection_Homo sapiens_hsa051100.76911565
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75665785
86Non-small cell lung cancer_Homo sapiens_hsa052230.75264285
87Inositol phosphate metabolism_Homo sapiens_hsa005620.74702671
88Renin-angiotensin system_Homo sapiens_hsa046140.74267327
89Base excision repair_Homo sapiens_hsa034100.73707339
90Mineral absorption_Homo sapiens_hsa049780.73372164
91Retinol metabolism_Homo sapiens_hsa008300.73295866
92ABC transporters_Homo sapiens_hsa020100.71872292
93Caffeine metabolism_Homo sapiens_hsa002320.70879368
94Linoleic acid metabolism_Homo sapiens_hsa005910.70796530
95Thyroid cancer_Homo sapiens_hsa052160.70493443
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69671411
97Arachidonic acid metabolism_Homo sapiens_hsa005900.69613753
98Pancreatic secretion_Homo sapiens_hsa049720.65706598
99Glucagon signaling pathway_Homo sapiens_hsa049220.64974021
100Estrogen signaling pathway_Homo sapiens_hsa049150.63438394
101N-Glycan biosynthesis_Homo sapiens_hsa005100.61330502
102Chronic myeloid leukemia_Homo sapiens_hsa052200.59656519
103Cell cycle_Homo sapiens_hsa041100.59187535
104Basal cell carcinoma_Homo sapiens_hsa052170.58258570
105Complement and coagulation cascades_Homo sapiens_hsa046100.58056657
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57984692
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.57249486
108Notch signaling pathway_Homo sapiens_hsa043300.56325707
109mTOR signaling pathway_Homo sapiens_hsa041500.55669566
110Tyrosine metabolism_Homo sapiens_hsa003500.53964329
111Insulin resistance_Homo sapiens_hsa049310.53752952
112Spliceosome_Homo sapiens_hsa030400.53481113
113Small cell lung cancer_Homo sapiens_hsa052220.53274605
114Vitamin B6 metabolism_Homo sapiens_hsa007500.51161024
115mRNA surveillance pathway_Homo sapiens_hsa030150.49411486
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.49175280
117Thyroid hormone synthesis_Homo sapiens_hsa049180.48770151
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47813407
119Prostate cancer_Homo sapiens_hsa052150.46759301
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.45858910
121GnRH signaling pathway_Homo sapiens_hsa049120.45360647
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45169705
123Hedgehog signaling pathway_Homo sapiens_hsa043400.44986734
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43416278
125Other glycan degradation_Homo sapiens_hsa005110.42102088
126Nucleotide excision repair_Homo sapiens_hsa034200.40795615
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39854850
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38667181
129Prolactin signaling pathway_Homo sapiens_hsa049170.38374914
130Endocytosis_Homo sapiens_hsa041440.37232693
131Cocaine addiction_Homo sapiens_hsa050300.36620190
132AMPK signaling pathway_Homo sapiens_hsa041520.36421103
133Metabolic pathways_Homo sapiens_hsa011000.35815903
134Ovarian steroidogenesis_Homo sapiens_hsa049130.34089163
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33995312
136TGF-beta signaling pathway_Homo sapiens_hsa043500.33591886
137Pyrimidine metabolism_Homo sapiens_hsa002400.32799933
138Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32681059
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.31363002
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30358982
141MicroRNAs in cancer_Homo sapiens_hsa052060.29735170
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.28622474

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