

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit biogenesis (GO:0042274) | 6.93187647 |
| 2 | viral transcription (GO:0019083) | 6.85141240 |
| 3 | ribosomal small subunit assembly (GO:0000028) | 6.65072861 |
| 4 | translational termination (GO:0006415) | 6.63141234 |
| 5 | maturation of SSU-rRNA (GO:0030490) | 6.12105145 |
| 6 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.81026220 |
| 7 | cotranslational protein targeting to membrane (GO:0006613) | 5.73481063 |
| 8 | protein targeting to ER (GO:0045047) | 5.71591889 |
| 9 | translational elongation (GO:0006414) | 5.65942767 |
| 10 | ribosomal large subunit biogenesis (GO:0042273) | 5.63419965 |
| 11 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 5.43845442 |
| 12 | protein localization to endoplasmic reticulum (GO:0070972) | 5.43447543 |
| 13 | DNA deamination (GO:0045006) | 5.31807400 |
| 14 | translational initiation (GO:0006413) | 5.26521721 |
| 15 | viral life cycle (GO:0019058) | 5.24494212 |
| 16 | cellular protein complex disassembly (GO:0043624) | 5.17886850 |
| 17 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 5.12656624 |
| 18 | proteasome assembly (GO:0043248) | 4.97386811 |
| 19 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.79247310 |
| 20 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.51084430 |
| 21 | termination of RNA polymerase III transcription (GO:0006386) | 4.51084430 |
| 22 | translation (GO:0006412) | 4.45946727 |
| 23 | protein complex disassembly (GO:0043241) | 4.41733140 |
| 24 | macromolecular complex disassembly (GO:0032984) | 4.20472856 |
| 25 | formation of translation preinitiation complex (GO:0001731) | 4.11934165 |
| 26 | rRNA processing (GO:0006364) | 4.11147133 |
| 27 | respiratory chain complex IV assembly (GO:0008535) | 3.97974727 |
| 28 | rRNA metabolic process (GO:0016072) | 3.96707093 |
| 29 | cellular component biogenesis (GO:0044085) | 3.96388969 |
| 30 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.90819035 |
| 31 | NADH dehydrogenase complex assembly (GO:0010257) | 3.90819035 |
| 32 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.90819035 |
| 33 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.88051700 |
| 34 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.86529192 |
| 35 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.85865484 |
| 36 | protein complex biogenesis (GO:0070271) | 3.83093439 |
| 37 | protein targeting to membrane (GO:0006612) | 3.73952185 |
| 38 | rRNA modification (GO:0000154) | 3.71993566 |
| 39 | ribosome biogenesis (GO:0042254) | 3.69833051 |
| 40 | pseudouridine synthesis (GO:0001522) | 3.69434729 |
| 41 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.67497726 |
| 42 | mRNA catabolic process (GO:0006402) | 3.66571402 |
| 43 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.63796194 |
| 44 | ATP synthesis coupled proton transport (GO:0015986) | 3.63796194 |
| 45 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.63589240 |
| 46 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.63294353 |
| 47 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.62873474 |
| 48 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.62032175 |
| 49 | 7-methylguanosine mRNA capping (GO:0006370) | 3.60396635 |
| 50 | negative regulation of ligase activity (GO:0051352) | 3.58018375 |
| 51 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.58018375 |
| 52 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.56891715 |
| 53 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.56569185 |
| 54 | 7-methylguanosine RNA capping (GO:0009452) | 3.55688647 |
| 55 | RNA capping (GO:0036260) | 3.55688647 |
| 56 | spliceosomal snRNP assembly (GO:0000387) | 3.51670049 |
| 57 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.51475523 |
| 58 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.50237513 |
| 59 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.50237513 |
| 60 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.49661297 |
| 61 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.49143839 |
| 62 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.49143839 |
| 63 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.49143839 |
| 64 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.47873596 |
| 65 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.47089592 |
| 66 | ribosome assembly (GO:0042255) | 3.46304076 |
| 67 | RNA catabolic process (GO:0006401) | 3.45026717 |
| 68 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.44746754 |
| 69 | DNA strand elongation (GO:0022616) | 3.44337943 |
| 70 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.44010475 |
| 71 | cytochrome complex assembly (GO:0017004) | 3.42999591 |
| 72 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.42167553 |
| 73 | protein neddylation (GO:0045116) | 3.41609786 |
| 74 | signal peptide processing (GO:0006465) | 3.40589080 |
| 75 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.40308320 |
| 76 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.40308320 |
| 77 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 3.38483606 |
| 78 | termination of RNA polymerase I transcription (GO:0006363) | 3.38043194 |
| 79 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.36929219 |
| 80 | tryptophan catabolic process (GO:0006569) | 3.35691911 |
| 81 | indole-containing compound catabolic process (GO:0042436) | 3.35691911 |
| 82 | indolalkylamine catabolic process (GO:0046218) | 3.35691911 |
| 83 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.35650977 |
| 84 | spliceosomal complex assembly (GO:0000245) | 3.35575587 |
| 85 | DNA double-strand break processing (GO:0000729) | 3.34249151 |
| 86 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.32018403 |
| 87 | transcription from RNA polymerase I promoter (GO:0006360) | 3.31205295 |
| 88 | double-strand break repair via homologous recombination (GO:0000724) | 3.30781353 |
| 89 | recombinational repair (GO:0000725) | 3.30618589 |
| 90 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.29204515 |
| 91 | chaperone-mediated protein transport (GO:0072321) | 3.28339491 |
| 92 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.28034512 |
| 93 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.28034512 |
| 94 | DNA replication initiation (GO:0006270) | 3.26220459 |
| 95 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.26024020 |
| 96 | kynurenine metabolic process (GO:0070189) | 3.25359465 |
| 97 | establishment of integrated proviral latency (GO:0075713) | 3.24147303 |
| 98 | protein-cofactor linkage (GO:0018065) | 3.23842242 |
| 99 | indolalkylamine metabolic process (GO:0006586) | 3.21401260 |
| 100 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.20589467 |
| 101 | telomere maintenance via recombination (GO:0000722) | 3.19819692 |
| 102 | platelet dense granule organization (GO:0060155) | 3.17860809 |
| 103 | DNA replication checkpoint (GO:0000076) | 3.17762833 |
| 104 | tRNA processing (GO:0008033) | 3.16115386 |
| 105 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.13650715 |
| 106 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.13650715 |
| 107 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.13220842 |
| 108 | cullin deneddylation (GO:0010388) | 3.12317021 |
| 109 | electron transport chain (GO:0022900) | 3.11120957 |
| 110 | replication fork processing (GO:0031297) | 3.09847974 |
| 111 | respiratory electron transport chain (GO:0022904) | 3.09320875 |
| 112 | nucleobase biosynthetic process (GO:0046112) | 3.06971357 |
| 113 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.06108267 |
| 114 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.04971500 |
| 115 | GTP biosynthetic process (GO:0006183) | 3.04602719 |
| 116 | purine nucleobase biosynthetic process (GO:0009113) | 3.03119206 |
| 117 | protein targeting to mitochondrion (GO:0006626) | 3.03015274 |
| 118 | regulation of mitochondrial translation (GO:0070129) | 3.02327991 |
| 119 | ncRNA processing (GO:0034470) | 3.01741691 |
| 120 | CENP-A containing nucleosome assembly (GO:0034080) | 3.01483775 |
| 121 | protein deneddylation (GO:0000338) | 3.01226839 |
| 122 | establishment of protein localization to mitochondrion (GO:0072655) | 2.99018352 |
| 123 | DNA damage response, detection of DNA damage (GO:0042769) | 2.98036896 |
| 124 | tryptophan metabolic process (GO:0006568) | 2.97415743 |
| 125 | positive regulation of ligase activity (GO:0051351) | 2.97213204 |
| 126 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.94370964 |
| 127 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.94370964 |
| 128 | isotype switching (GO:0045190) | 2.94370964 |
| 129 | fucose catabolic process (GO:0019317) | 2.93290446 |
| 130 | L-fucose metabolic process (GO:0042354) | 2.93290446 |
| 131 | L-fucose catabolic process (GO:0042355) | 2.93290446 |
| 132 | protein K6-linked ubiquitination (GO:0085020) | 2.91045285 |
| 133 | chromatin remodeling at centromere (GO:0031055) | 2.90670834 |
| 134 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.90637033 |
| 135 | peptidyl-histidine modification (GO:0018202) | 2.90128872 |
| 136 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.88293402 |
| 137 | protein K11-linked deubiquitination (GO:0035871) | 2.88149595 |
| 138 | centriole replication (GO:0007099) | 2.86767504 |
| 139 | ncRNA metabolic process (GO:0034660) | 2.85880835 |
| 140 | UTP biosynthetic process (GO:0006228) | 2.85844980 |
| 141 | histone mRNA metabolic process (GO:0008334) | 2.85032754 |
| 142 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.84295845 |
| 143 | cell cycle G1/S phase transition (GO:0044843) | 2.84295845 |
| 144 | rRNA methylation (GO:0031167) | 2.83883606 |
| 145 | maturation of 5.8S rRNA (GO:0000460) | 2.83817738 |
| 146 | behavioral response to nicotine (GO:0035095) | 2.82640412 |
| 147 | protein prenylation (GO:0018342) | 2.79207092 |
| 148 | prenylation (GO:0097354) | 2.79207092 |
| 149 | mitochondrial RNA metabolic process (GO:0000959) | 2.78423396 |
| 150 | rRNA catabolic process (GO:0016075) | 2.77635906 |
| 151 | piRNA metabolic process (GO:0034587) | 2.77286003 |
| 152 | neural tube formation (GO:0001841) | 2.76340627 |
| 153 | response to pheromone (GO:0019236) | 2.75750763 |
| 154 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.67099175 |
| 155 | tRNA metabolic process (GO:0006399) | 2.64330562 |
| 156 | mannosylation (GO:0097502) | 2.63835865 |
| 157 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.56960621 |
| 158 | reciprocal meiotic recombination (GO:0007131) | 2.53826630 |
| 159 | reciprocal DNA recombination (GO:0035825) | 2.53826630 |
| 160 | L-methionine biosynthetic process (GO:0071265) | 2.52251387 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.19589380 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.68928218 |
| 3 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.35871073 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.24017317 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.22385627 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.02261820 |
| 7 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.68820910 |
| 8 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.68587072 |
| 9 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.57094333 |
| 10 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.30925909 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.30899753 |
| 12 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.16110106 |
| 13 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.14535787 |
| 14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.08586231 |
| 15 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.06274160 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.00777405 |
| 17 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.91841378 |
| 18 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.89703550 |
| 19 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.85371113 |
| 20 | VDR_22108803_ChIP-Seq_LS180_Human | 2.79123309 |
| 21 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.75484609 |
| 22 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.71890356 |
| 23 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.65504948 |
| 24 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.62783628 |
| 25 | EWS_26573619_Chip-Seq_HEK293_Human | 2.44686188 |
| 26 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.44272681 |
| 27 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.35110566 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.35097253 |
| 29 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.23609440 |
| 30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.23467316 |
| 31 | FUS_26573619_Chip-Seq_HEK293_Human | 2.22781750 |
| 32 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.22322004 |
| 33 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.16123040 |
| 34 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.15848298 |
| 35 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.14455218 |
| 36 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.13538531 |
| 37 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.13305645 |
| 38 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.06448431 |
| 39 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.99079928 |
| 40 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.98095519 |
| 41 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.94755190 |
| 42 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.94370724 |
| 43 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.91060607 |
| 44 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.89034536 |
| 45 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.85845602 |
| 46 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.85782918 |
| 47 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.84116132 |
| 48 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.76327750 |
| 49 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.76310403 |
| 50 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.75784388 |
| 51 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.74873013 |
| 52 | P300_19829295_ChIP-Seq_ESCs_Human | 1.74488066 |
| 53 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.71767136 |
| 54 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.71735743 |
| 55 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.70828030 |
| 56 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.70324536 |
| 57 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.66925062 |
| 58 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.62817192 |
| 59 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.61593478 |
| 60 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.61525621 |
| 61 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.59495962 |
| 62 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.57807872 |
| 63 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.57284715 |
| 64 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.57127830 |
| 65 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.52125418 |
| 66 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.52078794 |
| 67 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.50373880 |
| 68 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.50220231 |
| 69 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.49888382 |
| 70 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.49268327 |
| 71 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.47216911 |
| 72 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.46035432 |
| 73 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.45006566 |
| 74 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.44952060 |
| 75 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.43574510 |
| 76 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.43450459 |
| 77 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.41640815 |
| 78 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.40117219 |
| 79 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37398371 |
| 80 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.35610361 |
| 81 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.34798576 |
| 82 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.30338444 |
| 83 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.29626646 |
| 84 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.29626646 |
| 85 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.27768763 |
| 86 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.26980050 |
| 87 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.26961406 |
| 88 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.24835273 |
| 89 | * SPI1_23547873_ChIP-Seq_NB4_Human | 1.24802878 |
| 90 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.24502927 |
| 91 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.23710878 |
| 92 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.22793677 |
| 93 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.22351260 |
| 94 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.21740518 |
| 95 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.20411077 |
| 96 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.20076512 |
| 97 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.20074669 |
| 98 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.19573273 |
| 99 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.17348368 |
| 100 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.17348368 |
| 101 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.15977658 |
| 102 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.15101754 |
| 103 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.15101754 |
| 104 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.12922710 |
| 105 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.11962724 |
| 106 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.10931357 |
| 107 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.10712774 |
| 108 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.10227938 |
| 109 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.08233594 |
| 110 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.08233361 |
| 111 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.07713107 |
| 112 | AR_20517297_ChIP-Seq_VCAP_Human | 1.06819451 |
| 113 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.05252901 |
| 114 | STAT3_23295773_ChIP-Seq_U87_Human | 1.03190426 |
| 115 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.03103995 |
| 116 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.02595947 |
| 117 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.02562291 |
| 118 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.00940234 |
| 119 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.00417021 |
| 120 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.99998673 |
| 121 | * CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.99686479 |
| 122 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.98844445 |
| 123 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.98808421 |
| 124 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.98356663 |
| 125 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.98236583 |
| 126 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.97329965 |
| 127 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.96109705 |
| 128 | AR_25329375_ChIP-Seq_VCAP_Human | 0.95713128 |
| 129 | TCF4_23295773_ChIP-Seq_U87_Human | 0.95523541 |
| 130 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.95436365 |
| 131 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.93765914 |
| 132 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.93158651 |
| 133 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.92886984 |
| 134 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.92778841 |
| 135 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.92336675 |
| 136 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.92210549 |
| 137 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.91438696 |
| 138 | NCOR_22424771_ChIP-Seq_293T_Human | 0.91358321 |
| 139 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.91185969 |
| 140 | * FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.90172675 |
| 141 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.90136833 |
| 142 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.89286066 |
| 143 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.88824974 |
| 144 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.88796054 |
| 145 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.88313996 |
| 146 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87549872 |
| 147 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.87344753 |
| 148 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.81199101 |
| 149 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.80881146 |
| 150 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.77234605 |
| 151 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.76300597 |
| 152 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.75857879 |
| 153 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.75703457 |
| 154 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.74193642 |
| 155 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.73190497 |
| 156 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.73083099 |
| 157 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.71673697 |
| 158 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.71539934 |
| 159 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.71149149 |
| 160 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.70512608 |
| 161 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.69505385 |
| 162 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 0.66704832 |
| 163 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.64217193 |
| 164 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.63738485 |
| 165 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.63514355 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.13490805 |
| 2 | MP0009379_abnormal_foot_pigmentation | 3.89823401 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 3.89716483 |
| 4 | MP0008057_abnormal_DNA_replication | 3.32692554 |
| 5 | MP0000569_abnormal_digit_pigmentation | 3.28017581 |
| 6 | MP0010094_abnormal_chromosome_stability | 3.17955375 |
| 7 | MP0008058_abnormal_DNA_repair | 2.97152521 |
| 8 | MP0003111_abnormal_nucleus_morphology | 2.96465790 |
| 9 | MP0003077_abnormal_cell_cycle | 2.90753199 |
| 10 | MP0006072_abnormal_retinal_apoptosis | 2.56369978 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.55473344 |
| 12 | MP0003718_maternal_effect | 2.39396792 |
| 13 | MP0003195_calcinosis | 2.36689163 |
| 14 | MP0003136_yellow_coat_color | 2.21379093 |
| 15 | MP0003786_premature_aging | 2.19589288 |
| 16 | MP0002837_dystrophic_cardiac_calcinosis | 2.19567529 |
| 17 | MP0002396_abnormal_hematopoietic_system | 2.19275959 |
| 18 | MP0008007_abnormal_cellular_replicative | 2.17768843 |
| 19 | MP0004381_abnormal_hair_follicle | 2.02774535 |
| 20 | MP0005551_abnormal_eye_electrophysiolog | 2.02643915 |
| 21 | MP0009333_abnormal_splenocyte_physiolog | 2.02560032 |
| 22 | MP0003646_muscle_fatigue | 1.97296676 |
| 23 | MP0000427_abnormal_hair_cycle | 1.95613246 |
| 24 | MP0006292_abnormal_olfactory_placode | 1.93979376 |
| 25 | MP0003186_abnormal_redox_activity | 1.93100239 |
| 26 | MP0002132_abnormal_respiratory_system | 1.92464997 |
| 27 | MP0002736_abnormal_nociception_after | 1.88564079 |
| 28 | MP0005253_abnormal_eye_physiology | 1.87633334 |
| 29 | MP0005084_abnormal_gallbladder_morpholo | 1.85316886 |
| 30 | MP0004142_abnormal_muscle_tone | 1.78210007 |
| 31 | MP0008872_abnormal_physiological_respon | 1.77610979 |
| 32 | MP0005671_abnormal_response_to | 1.77200063 |
| 33 | MP0009785_altered_susceptibility_to | 1.76315689 |
| 34 | MP0000490_abnormal_crypts_of | 1.75170822 |
| 35 | MP0002148_abnormal_hypersensitivity_rea | 1.72381457 |
| 36 | MP0001835_abnormal_antigen_presentation | 1.71757823 |
| 37 | MP0003763_abnormal_thymus_physiology | 1.59535065 |
| 38 | MP0005075_abnormal_melanosome_morpholog | 1.59214831 |
| 39 | MP0001853_heart_inflammation | 1.53099495 |
| 40 | MP0003315_abnormal_perineum_morphology | 1.51561017 |
| 41 | MP0002876_abnormal_thyroid_physiology | 1.50697307 |
| 42 | MP0001968_abnormal_touch/_nociception | 1.48523492 |
| 43 | MP0002277_abnormal_respiratory_mucosa | 1.43485897 |
| 44 | MP0003950_abnormal_plasma_membrane | 1.42429285 |
| 45 | MP0008995_early_reproductive_senescence | 1.42007886 |
| 46 | MP0005025_abnormal_response_to | 1.41603717 |
| 47 | MP0005389_reproductive_system_phenotype | 1.41319990 |
| 48 | MP0005646_abnormal_pituitary_gland | 1.40619758 |
| 49 | MP0005000_abnormal_immune_tolerance | 1.39475418 |
| 50 | MP0002163_abnormal_gland_morphology | 1.37645783 |
| 51 | MP0000372_irregular_coat_pigmentation | 1.37062101 |
| 52 | MP0008875_abnormal_xenobiotic_pharmacok | 1.36769187 |
| 53 | MP0000383_abnormal_hair_follicle | 1.36309550 |
| 54 | MP0002398_abnormal_bone_marrow | 1.34537846 |
| 55 | MP0001529_abnormal_vocalization | 1.32826701 |
| 56 | MP0002723_abnormal_immune_serum | 1.30377055 |
| 57 | MP0001800_abnormal_humoral_immune | 1.29501684 |
| 58 | MP0002138_abnormal_hepatobiliary_system | 1.29260739 |
| 59 | MP0001986_abnormal_taste_sensitivity | 1.29037128 |
| 60 | MP0000350_abnormal_cell_proliferation | 1.28803654 |
| 61 | MP0001905_abnormal_dopamine_level | 1.28751033 |
| 62 | MP0002452_abnormal_antigen_presenting | 1.27550533 |
| 63 | MP0002420_abnormal_adaptive_immunity | 1.26989182 |
| 64 | MP0001485_abnormal_pinna_reflex | 1.26463491 |
| 65 | MP0001819_abnormal_immune_cell | 1.25934511 |
| 66 | MP0002095_abnormal_skin_pigmentation | 1.24132488 |
| 67 | MP0002722_abnormal_immune_system | 1.23096368 |
| 68 | MP0001730_embryonic_growth_arrest | 1.23030976 |
| 69 | MP0003436_decreased_susceptibility_to | 1.21742041 |
| 70 | MP0000689_abnormal_spleen_morphology | 1.21474568 |
| 71 | MP0008260_abnormal_autophagy | 1.21196868 |
| 72 | MP0000685_abnormal_immune_system | 1.19004927 |
| 73 | MP0003806_abnormal_nucleotide_metabolis | 1.18974552 |
| 74 | MP0000631_abnormal_neuroendocrine_gland | 1.17197734 |
| 75 | MP0000313_abnormal_cell_death | 1.16956480 |
| 76 | MP0000716_abnormal_immune_system | 1.16328192 |
| 77 | MP0002019_abnormal_tumor_incidence | 1.15290656 |
| 78 | MP0002429_abnormal_blood_cell | 1.14836680 |
| 79 | MP0005174_abnormal_tail_pigmentation | 1.14151836 |
| 80 | MP0005310_abnormal_salivary_gland | 1.13748384 |
| 81 | MP0002102_abnormal_ear_morphology | 1.12424534 |
| 82 | MP0001919_abnormal_reproductive_system | 1.11714060 |
| 83 | MP0003252_abnormal_bile_duct | 1.11235204 |
| 84 | MP0005451_abnormal_body_composition | 1.08519408 |
| 85 | MP0002638_abnormal_pupillary_reflex | 1.08327649 |
| 86 | MP0001501_abnormal_sleep_pattern | 1.07628490 |
| 87 | MP0000703_abnormal_thymus_morphology | 1.07052169 |
| 88 | MP0004043_abnormal_pH_regulation | 1.05418947 |
| 89 | MP0000015_abnormal_ear_pigmentation | 1.05072207 |
| 90 | MP0000858_altered_metastatic_potential | 1.04850322 |
| 91 | MP0010386_abnormal_urinary_bladder | 1.04761087 |
| 92 | MP0002405_respiratory_system_inflammati | 1.04727427 |
| 93 | MP0009046_muscle_twitch | 1.04606420 |
| 94 | MP0001188_hyperpigmentation | 1.04325479 |
| 95 | MP0001984_abnormal_olfaction | 1.02925175 |
| 96 | MP0003724_increased_susceptibility_to | 1.02388965 |
| 97 | MP0005645_abnormal_hypothalamus_physiol | 1.02211423 |
| 98 | MP0006036_abnormal_mitochondrial_physio | 1.02210868 |
| 99 | MP0005397_hematopoietic_system_phenotyp | 1.01873203 |
| 100 | MP0001545_abnormal_hematopoietic_system | 1.01873203 |
| 101 | MP0002419_abnormal_innate_immunity | 1.00682610 |
| 102 | MP0001764_abnormal_homeostasis | 1.00606630 |
| 103 | MP0004215_abnormal_myocardial_fiber | 1.00286727 |
| 104 | MP0000647_abnormal_sebaceous_gland | 0.99851134 |
| 105 | MP0002928_abnormal_bile_duct | 0.99392396 |
| 106 | MP0005409_darkened_coat_color | 0.98129613 |
| 107 | MP0001929_abnormal_gametogenesis | 0.97593400 |
| 108 | MP0005410_abnormal_fertilization | 0.96615799 |
| 109 | MP0004808_abnormal_hematopoietic_stem | 0.95771143 |
| 110 | MP0004885_abnormal_endolymph | 0.94395916 |
| 111 | MP0009745_abnormal_behavioral_response | 0.94324129 |
| 112 | MP0005266_abnormal_metabolism | 0.93606258 |
| 113 | MP0002254_reproductive_system_inflammat | 0.93485793 |
| 114 | MP0000371_diluted_coat_color | 0.91857783 |
| 115 | MP0001542_abnormal_bone_strength | 0.91049939 |
| 116 | MP0005408_hypopigmentation | 0.89806071 |
| 117 | MP0002938_white_spotting | 0.88250525 |
| 118 | MP0008877_abnormal_DNA_methylation | 0.86536365 |
| 119 | MP0000465_gastrointestinal_hemorrhage | 0.86047359 |
| 120 | MP0002693_abnormal_pancreas_physiology | 0.85377675 |
| 121 | MP0006035_abnormal_mitochondrial_morpho | 0.85321328 |
| 122 | MP0000653_abnormal_sex_gland | 0.84662344 |
| 123 | MP0003567_abnormal_fetal_cardiomyocyte | 0.84326069 |
| 124 | MP0001324_abnormal_eye_pigmentation | 0.84073375 |
| 125 | MP0002090_abnormal_vision | 0.83629542 |
| 126 | MP0005387_immune_system_phenotype | 0.83621560 |
| 127 | MP0001790_abnormal_immune_system | 0.83621560 |
| 128 | MP0003011_delayed_dark_adaptation | 0.83315073 |
| 129 | MP0002210_abnormal_sex_determination | 0.83181735 |
| 130 | MP0001727_abnormal_embryo_implantation | 0.82420305 |
| 131 | MP0009697_abnormal_copulation | 0.82267567 |
| 132 | MP0002080_prenatal_lethality | 0.80678790 |
| 133 | MP0005195_abnormal_posterior_eye | 0.80548425 |
| 134 | MP0010678_abnormal_skin_adnexa | 0.80396926 |
| 135 | MP0005379_endocrine/exocrine_gland_phen | 0.80148104 |
| 136 | MP0001119_abnormal_female_reproductive | 0.78860615 |
| 137 | MP0002751_abnormal_autonomic_nervous | 0.78845244 |
| 138 | MP0006082_CNS_inflammation | 0.78759965 |
| 139 | MP0003941_abnormal_skin_development | 0.77785684 |
| 140 | MP0001697_abnormal_embryo_size | 0.77441637 |
| 141 | MP0009764_decreased_sensitivity_to | 0.77271033 |
| 142 | MP0004147_increased_porphyrin_level | 0.75394157 |
| 143 | MP0010155_abnormal_intestine_physiology | 0.74526954 |
| 144 | MP0001145_abnormal_male_reproductive | 0.73220486 |
| 145 | MP0003698_abnormal_male_reproductive | 0.72693953 |
| 146 | MP0001293_anophthalmia | 0.72149466 |
| 147 | MP0003937_abnormal_limbs/digits/tail_de | 0.71250222 |
| 148 | MP0003938_abnormal_ear_development | 0.70788770 |
| 149 | MP0005395_other_phenotype | 0.70355540 |
| 150 | MP0001845_abnormal_inflammatory_respons | 0.70023107 |
| 151 | MP0005647_abnormal_sex_gland | 0.69655870 |
| 152 | MP0005501_abnormal_skin_physiology | 0.68950649 |
| 153 | MP0000358_abnormal_cell_content/ | 0.68883534 |
| 154 | MP0003123_paternal_imprinting | 0.67912011 |
| 155 | MP0003787_abnormal_imprinting | 0.67269112 |
| 156 | MP0002006_tumorigenesis | 0.66884769 |
| 157 | MP0005391_vision/eye_phenotype | 0.66117314 |
| 158 | MP0008789_abnormal_olfactory_epithelium | 0.65563290 |
| 159 | MP0006054_spinal_hemorrhage | 0.65411091 |
| 160 | MP0002160_abnormal_reproductive_system | 0.65057248 |
| 161 | MP0000613_abnormal_salivary_gland | 0.65050028 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 6.38283622 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.81808510 |
| 3 | Reticulocytopenia (HP:0001896) | 5.55804827 |
| 4 | Macrocytic anemia (HP:0001972) | 4.69115149 |
| 5 | Pancreatic cysts (HP:0001737) | 4.50554883 |
| 6 | Pallor (HP:0000980) | 4.25526535 |
| 7 | Increased hepatocellular lipid droplets (HP:0006565) | 4.05075617 |
| 8 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.78237625 |
| 9 | Mitochondrial inheritance (HP:0001427) | 3.76562168 |
| 10 | Acute necrotizing encephalopathy (HP:0006965) | 3.69383633 |
| 11 | True hermaphroditism (HP:0010459) | 3.64991913 |
| 12 | Birth length less than 3rd percentile (HP:0003561) | 3.64811997 |
| 13 | Pancreatic fibrosis (HP:0100732) | 3.64303572 |
| 14 | 3-Methylglutaconic aciduria (HP:0003535) | 3.63611005 |
| 15 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.51676959 |
| 16 | Abnormality of midbrain morphology (HP:0002418) | 3.44103310 |
| 17 | Molar tooth sign on MRI (HP:0002419) | 3.44103310 |
| 18 | Lipid accumulation in hepatocytes (HP:0006561) | 3.39095508 |
| 19 | Increased CSF lactate (HP:0002490) | 3.29846353 |
| 20 | Hepatocellular necrosis (HP:0001404) | 3.28961285 |
| 21 | Aplastic anemia (HP:0001915) | 3.27890423 |
| 22 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.25968212 |
| 23 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.25968212 |
| 24 | Breast hypoplasia (HP:0003187) | 3.25525741 |
| 25 | Cerebral hypomyelination (HP:0006808) | 3.24852050 |
| 26 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.18021615 |
| 27 | Congenital stationary night blindness (HP:0007642) | 3.15517555 |
| 28 | Renal Fanconi syndrome (HP:0001994) | 3.15201172 |
| 29 | Rough bone trabeculation (HP:0100670) | 3.13689931 |
| 30 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.12012145 |
| 31 | Exertional dyspnea (HP:0002875) | 3.12002820 |
| 32 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.99608347 |
| 33 | Abnormality of alanine metabolism (HP:0010916) | 2.99608347 |
| 34 | Hyperalaninemia (HP:0003348) | 2.99608347 |
| 35 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.99460514 |
| 36 | Nephronophthisis (HP:0000090) | 2.98957077 |
| 37 | Parakeratosis (HP:0001036) | 2.87296426 |
| 38 | Increased serum lactate (HP:0002151) | 2.85979260 |
| 39 | Progressive macrocephaly (HP:0004481) | 2.82989771 |
| 40 | Abnormality of the renal cortex (HP:0011035) | 2.79743453 |
| 41 | Hepatic necrosis (HP:0002605) | 2.79369133 |
| 42 | Acute encephalopathy (HP:0006846) | 2.77839789 |
| 43 | Type I transferrin isoform profile (HP:0003642) | 2.75953992 |
| 44 | Oral leukoplakia (HP:0002745) | 2.75835371 |
| 45 | Attenuation of retinal blood vessels (HP:0007843) | 2.64866856 |
| 46 | Abnormality of the renal medulla (HP:0100957) | 2.61551744 |
| 47 | Respiratory difficulties (HP:0002880) | 2.58523045 |
| 48 | Abnormal hemoglobin (HP:0011902) | 2.58336579 |
| 49 | Congenital, generalized hypertrichosis (HP:0004540) | 2.55369241 |
| 50 | Medial flaring of the eyebrow (HP:0010747) | 2.54288474 |
| 51 | Increased intramyocellular lipid droplets (HP:0012240) | 2.53735068 |
| 52 | Abnormal trabecular bone morphology (HP:0100671) | 2.53513171 |
| 53 | Microvesicular hepatic steatosis (HP:0001414) | 2.53030618 |
| 54 | Methylmalonic acidemia (HP:0002912) | 2.47140125 |
| 55 | Carpal bone hypoplasia (HP:0001498) | 2.46696056 |
| 56 | Sparse eyelashes (HP:0000653) | 2.46612204 |
| 57 | Abolished electroretinogram (ERG) (HP:0000550) | 2.45406649 |
| 58 | Renal cortical cysts (HP:0000803) | 2.44045147 |
| 59 | Abnormality of the pons (HP:0007361) | 2.43847289 |
| 60 | Type II lissencephaly (HP:0007260) | 2.41703056 |
| 61 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.38889806 |
| 62 | Cleft eyelid (HP:0000625) | 2.38721511 |
| 63 | Pendular nystagmus (HP:0012043) | 2.38687673 |
| 64 | Hypoplasia of the pons (HP:0012110) | 2.37396705 |
| 65 | Trismus (HP:0000211) | 2.34107337 |
| 66 | Large for gestational age (HP:0001520) | 2.33713303 |
| 67 | Multiple enchondromatosis (HP:0005701) | 2.33500950 |
| 68 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.33049316 |
| 69 | Premature graying of hair (HP:0002216) | 2.31012452 |
| 70 | Exercise intolerance (HP:0003546) | 2.28643450 |
| 71 | Thrombocytosis (HP:0001894) | 2.28480180 |
| 72 | Sclerocornea (HP:0000647) | 2.26643261 |
| 73 | Increased serum pyruvate (HP:0003542) | 2.23968033 |
| 74 | Abnormality of glycolysis (HP:0004366) | 2.23968033 |
| 75 | Abnormality of the ileum (HP:0001549) | 2.22064621 |
| 76 | Abnormality of the preputium (HP:0100587) | 2.21820063 |
| 77 | Abnormality of the axillary hair (HP:0100134) | 2.21405868 |
| 78 | Abnormality of secondary sexual hair (HP:0009888) | 2.21405868 |
| 79 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.21394744 |
| 80 | Respiratory failure (HP:0002878) | 2.19990672 |
| 81 | Pancytopenia (HP:0001876) | 2.19837227 |
| 82 | Poor head control (HP:0002421) | 2.19673903 |
| 83 | Absent thumb (HP:0009777) | 2.18761943 |
| 84 | Methylmalonic aciduria (HP:0012120) | 2.17394531 |
| 85 | Cystic liver disease (HP:0006706) | 2.16427591 |
| 86 | Premature ovarian failure (HP:0008209) | 2.16425292 |
| 87 | Microretrognathia (HP:0000308) | 2.16247366 |
| 88 | Patellar aplasia (HP:0006443) | 2.15927674 |
| 89 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.15389174 |
| 90 | Gaze-evoked nystagmus (HP:0000640) | 2.14059905 |
| 91 | Cerebral edema (HP:0002181) | 2.12907572 |
| 92 | Triphalangeal thumb (HP:0001199) | 2.12558873 |
| 93 | Lactic acidosis (HP:0003128) | 2.11641735 |
| 94 | Abnormality of chromosome stability (HP:0003220) | 2.11634599 |
| 95 | Progressive inability to walk (HP:0002505) | 2.10954103 |
| 96 | Secondary amenorrhea (HP:0000869) | 2.10301472 |
| 97 | Male pseudohermaphroditism (HP:0000037) | 2.07570518 |
| 98 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.06930317 |
| 99 | Amniotic constriction ring (HP:0009775) | 2.06669245 |
| 100 | Abnormality of placental membranes (HP:0011409) | 2.06669245 |
| 101 | Constricted visual fields (HP:0001133) | 2.06102946 |
| 102 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.05732108 |
| 103 | Furrowed tongue (HP:0000221) | 2.05645145 |
| 104 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.02760666 |
| 105 | Inability to walk (HP:0002540) | 2.02007983 |
| 106 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.01062964 |
| 107 | Glossoptosis (HP:0000162) | 1.99758109 |
| 108 | Depressed nasal ridge (HP:0000457) | 1.99357023 |
| 109 | Petechiae (HP:0000967) | 1.98491367 |
| 110 | Clubbing of toes (HP:0100760) | 1.98126554 |
| 111 | IgM deficiency (HP:0002850) | 1.95836357 |
| 112 | Colon cancer (HP:0003003) | 1.94425393 |
| 113 | Chronic hepatic failure (HP:0100626) | 1.93302969 |
| 114 | Chromsome breakage (HP:0040012) | 1.93277205 |
| 115 | Abnormality of renal resorption (HP:0011038) | 1.92533267 |
| 116 | Bile duct proliferation (HP:0001408) | 1.92338307 |
| 117 | Abnormal biliary tract physiology (HP:0012439) | 1.92338307 |
| 118 | Increased muscle lipid content (HP:0009058) | 1.91540983 |
| 119 | Muscle fiber atrophy (HP:0100295) | 1.88398443 |
| 120 | Stenosis of the external auditory canal (HP:0000402) | 1.88068986 |
| 121 | Asplenia (HP:0001746) | 1.88065408 |
| 122 | Type 2 muscle fiber atrophy (HP:0003554) | 1.87809155 |
| 123 | Bone marrow hypocellularity (HP:0005528) | 1.87297007 |
| 124 | Hypoplasia of the radius (HP:0002984) | 1.87040013 |
| 125 | Optic disc pallor (HP:0000543) | 1.86698288 |
| 126 | Sloping forehead (HP:0000340) | 1.86662952 |
| 127 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.85512706 |
| 128 | Small hand (HP:0200055) | 1.85127532 |
| 129 | CNS hypomyelination (HP:0003429) | 1.85126141 |
| 130 | CNS demyelination (HP:0007305) | 1.84750918 |
| 131 | Meckel diverticulum (HP:0002245) | 1.82930155 |
| 132 | Reduced antithrombin III activity (HP:0001976) | 1.82533535 |
| 133 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.82489177 |
| 134 | IgG deficiency (HP:0004315) | 1.81440628 |
| 135 | Degeneration of anterior horn cells (HP:0002398) | 1.81286608 |
| 136 | Abnormality of the anterior horn cell (HP:0006802) | 1.81286608 |
| 137 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.81157104 |
| 138 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.81157104 |
| 139 | Abnormal protein glycosylation (HP:0012346) | 1.81157104 |
| 140 | Abnormal glycosylation (HP:0012345) | 1.81157104 |
| 141 | Anencephaly (HP:0002323) | 1.80982962 |
| 142 | Tubular atrophy (HP:0000092) | 1.80498583 |
| 143 | Irregular epiphyses (HP:0010582) | 1.80260558 |
| 144 | Horseshoe kidney (HP:0000085) | 1.79567068 |
| 145 | Lethargy (HP:0001254) | 1.79354409 |
| 146 | Agnosia (HP:0010524) | 1.78629324 |
| 147 | Ketoacidosis (HP:0001993) | 1.77919002 |
| 148 | Cerebellar dysplasia (HP:0007033) | 1.77847486 |
| 149 | Lymphoma (HP:0002665) | 1.77660705 |
| 150 | Hyperventilation (HP:0002883) | 1.77526880 |
| 151 | Congenital primary aphakia (HP:0007707) | 1.77301205 |
| 152 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.76890774 |
| 153 | Decreased central vision (HP:0007663) | 1.76100832 |
| 154 | 11 pairs of ribs (HP:0000878) | 1.75955560 |
| 155 | Hypothermia (HP:0002045) | 1.75075366 |
| 156 | Cellular immunodeficiency (HP:0005374) | 1.74930058 |
| 157 | Congenital sensorineural hearing impairment (HP:0008527) | 1.74808616 |
| 158 | Abnormality of serum amino acid levels (HP:0003112) | 1.73154764 |
| 159 | Thyroiditis (HP:0100646) | 1.70393665 |
| 160 | Congenital hepatic fibrosis (HP:0002612) | 1.70230934 |
| 161 | Gait imbalance (HP:0002141) | 1.69375902 |
| 162 | Abnormality of the labia minora (HP:0012880) | 1.68427276 |
| 163 | Clumsiness (HP:0002312) | 1.64419321 |
| 164 | Nephrogenic diabetes insipidus (HP:0009806) | 1.63924861 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FRK | 5.47047473 |
| 2 | NME2 | 4.90962809 |
| 3 | STK16 | 4.06103745 |
| 4 | BUB1 | 3.90660512 |
| 5 | EIF2AK1 | 3.71280906 |
| 6 | WEE1 | 3.56716035 |
| 7 | EIF2AK3 | 2.99452623 |
| 8 | PIM2 | 2.62364930 |
| 9 | SRPK1 | 2.22299450 |
| 10 | VRK1 | 2.19313146 |
| 11 | VRK2 | 2.11580324 |
| 12 | PBK | 2.08826249 |
| 13 | TLK1 | 2.04078448 |
| 14 | MAP4K2 | 2.01688499 |
| 15 | PLK4 | 2.00762280 |
| 16 | NME1 | 1.95214525 |
| 17 | MST4 | 1.84602127 |
| 18 | TESK2 | 1.82181882 |
| 19 | WNK3 | 1.77740191 |
| 20 | GRK1 | 1.77586386 |
| 21 | MKNK1 | 1.63275485 |
| 22 | CDC7 | 1.62057116 |
| 23 | TRIM28 | 1.61858400 |
| 24 | TSSK6 | 1.60012727 |
| 25 | TAOK3 | 1.56722042 |
| 26 | INSRR | 1.47852888 |
| 27 | DYRK3 | 1.45580233 |
| 28 | IRAK4 | 1.42176572 |
| 29 | IRAK3 | 1.39889397 |
| 30 | ACVR1B | 1.39303999 |
| 31 | OXSR1 | 1.37662174 |
| 32 | BRSK2 | 1.33663563 |
| 33 | RPS6KB2 | 1.32898530 |
| 34 | KDR | 1.24667865 |
| 35 | MKNK2 | 1.23089882 |
| 36 | CDK7 | 1.21101462 |
| 37 | PLK1 | 1.20742581 |
| 38 | EIF2AK2 | 1.15623244 |
| 39 | RPS6KA4 | 1.14993429 |
| 40 | MAP3K12 | 1.12285876 |
| 41 | AURKB | 1.12085231 |
| 42 | TAF1 | 1.09917653 |
| 43 | CDK19 | 1.09801062 |
| 44 | BLK | 1.07777006 |
| 45 | ARAF | 1.07135024 |
| 46 | ERBB3 | 1.04972714 |
| 47 | ZAK | 1.03840479 |
| 48 | AURKA | 1.03636382 |
| 49 | TXK | 1.03109314 |
| 50 | TTK | 1.02663354 |
| 51 | EPHA2 | 1.00828637 |
| 52 | MAPK13 | 0.99429312 |
| 53 | PINK1 | 0.97562842 |
| 54 | MAP4K1 | 0.96009868 |
| 55 | WNK4 | 0.95094852 |
| 56 | ABL2 | 0.94274783 |
| 57 | IKBKB | 0.94274439 |
| 58 | DYRK2 | 0.93970216 |
| 59 | ADRBK2 | 0.89877099 |
| 60 | TEC | 0.88951813 |
| 61 | BRAF | 0.88187503 |
| 62 | ADRBK1 | 0.87977746 |
| 63 | CDK8 | 0.87110704 |
| 64 | MARK3 | 0.86753456 |
| 65 | MAPKAPK5 | 0.83299667 |
| 66 | RPS6KA5 | 0.82539559 |
| 67 | PDK2 | 0.81772827 |
| 68 | PLK3 | 0.79736296 |
| 69 | ATR | 0.79609442 |
| 70 | PIM1 | 0.78164011 |
| 71 | NEK2 | 0.78069094 |
| 72 | LIMK1 | 0.77973960 |
| 73 | CSNK2A1 | 0.77972435 |
| 74 | STK3 | 0.76807804 |
| 75 | NEK1 | 0.75695687 |
| 76 | TNIK | 0.74867772 |
| 77 | CSNK2A2 | 0.74711313 |
| 78 | PLK2 | 0.73308795 |
| 79 | PAK3 | 0.73216595 |
| 80 | MAP3K11 | 0.72818295 |
| 81 | STK38L | 0.69128433 |
| 82 | TGFBR1 | 0.67335801 |
| 83 | CHEK2 | 0.67008846 |
| 84 | CLK1 | 0.66987150 |
| 85 | PAK1 | 0.63161524 |
| 86 | PRKCE | 0.63053855 |
| 87 | BRSK1 | 0.63045514 |
| 88 | ILK | 0.62385543 |
| 89 | CSNK1G3 | 0.61638021 |
| 90 | MAP3K8 | 0.61301525 |
| 91 | CAMKK2 | 0.60540588 |
| 92 | PNCK | 0.60426106 |
| 93 | KIT | 0.59914399 |
| 94 | BMPR1B | 0.59729133 |
| 95 | BCR | 0.58398416 |
| 96 | NLK | 0.58143542 |
| 97 | CASK | 0.57375136 |
| 98 | LRRK2 | 0.56960377 |
| 99 | BTK | 0.55888543 |
| 100 | LYN | 0.55624983 |
| 101 | CHUK | 0.55624047 |
| 102 | STK10 | 0.54587976 |
| 103 | PIK3CG | 0.53804140 |
| 104 | CSNK1G2 | 0.50944916 |
| 105 | CSNK1A1L | 0.49592686 |
| 106 | ZAP70 | 0.49495913 |
| 107 | PRKCG | 0.48817319 |
| 108 | SYK | 0.48642271 |
| 109 | GRK7 | 0.48044472 |
| 110 | MAP2K6 | 0.47937308 |
| 111 | MAP3K4 | 0.47314249 |
| 112 | MUSK | 0.46995636 |
| 113 | AKT3 | 0.46976875 |
| 114 | CSNK1G1 | 0.46028236 |
| 115 | STK4 | 0.45893186 |
| 116 | BCKDK | 0.45031263 |
| 117 | CHEK1 | 0.44599389 |
| 118 | BMPR2 | 0.44575805 |
| 119 | YES1 | 0.43813764 |
| 120 | MAPKAPK3 | 0.43663519 |
| 121 | PRKCI | 0.43061195 |
| 122 | CCNB1 | 0.42898465 |
| 123 | PIK3CA | 0.42296667 |
| 124 | PRKCQ | 0.41255038 |
| 125 | LATS1 | 0.40226934 |
| 126 | IRAK2 | 0.39045751 |
| 127 | PASK | 0.38053553 |
| 128 | TRPM7 | 0.37581356 |
| 129 | CDK4 | 0.37245816 |
| 130 | PAK4 | 0.36915381 |
| 131 | TESK1 | 0.36719388 |
| 132 | STK39 | 0.34593051 |
| 133 | LCK | 0.34396768 |
| 134 | NUAK1 | 0.33706198 |
| 135 | MATK | 0.32904376 |
| 136 | CSF1R | 0.32852821 |
| 137 | RAF1 | 0.32766036 |
| 138 | CSNK1A1 | 0.32083936 |
| 139 | CDK3 | 0.31113156 |
| 140 | ATM | 0.30655617 |
| 141 | MOS | 0.30555401 |
| 142 | MYLK | 0.30425939 |
| 143 | IKBKE | 0.30103767 |
| 144 | PTK2B | 0.29678022 |
| 145 | CSNK1D | 0.29663622 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 6.00280268 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.51535413 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 4.13171038 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.55145188 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.19557546 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 2.92553562 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.79584424 |
| 8 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.61876535 |
| 9 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.55321586 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.38933608 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.33231356 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 2.21317483 |
| 13 | Parkinsons disease_Homo sapiens_hsa05012 | 2.20887149 |
| 14 | Protein export_Homo sapiens_hsa03060 | 2.19455739 |
| 15 | RNA transport_Homo sapiens_hsa03013 | 2.14816649 |
| 16 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.11719977 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.94937147 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.79133973 |
| 19 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.75300679 |
| 20 | Phototransduction_Homo sapiens_hsa04744 | 1.64763087 |
| 21 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.59445685 |
| 22 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.56998625 |
| 23 | RNA degradation_Homo sapiens_hsa03018 | 1.56670280 |
| 24 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.55628007 |
| 25 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.53360645 |
| 26 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.51804551 |
| 27 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.48207214 |
| 28 | Cell cycle_Homo sapiens_hsa04110 | 1.45529666 |
| 29 | Alzheimers disease_Homo sapiens_hsa05010 | 1.44437300 |
| 30 | Purine metabolism_Homo sapiens_hsa00230 | 1.41727225 |
| 31 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.38782135 |
| 32 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.37525961 |
| 33 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.36623110 |
| 34 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.23739890 |
| 35 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.22137922 |
| 36 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.19428546 |
| 37 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.17000206 |
| 38 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.14403570 |
| 39 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.14359295 |
| 40 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.11836965 |
| 41 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.10755355 |
| 42 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.10168608 |
| 43 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.07931174 |
| 44 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.01523474 |
| 45 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.97854581 |
| 46 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.95396451 |
| 47 | Sulfur relay system_Homo sapiens_hsa04122 | 0.91010009 |
| 48 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.90576200 |
| 49 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.86231281 |
| 50 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.84161601 |
| 51 | Peroxisome_Homo sapiens_hsa04146 | 0.83226914 |
| 52 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.82593059 |
| 53 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.82063634 |
| 54 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.81679363 |
| 55 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.80704352 |
| 56 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.80080419 |
| 57 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.79310522 |
| 58 | Allograft rejection_Homo sapiens_hsa05330 | 0.78486040 |
| 59 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.78481750 |
| 60 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.76967270 |
| 61 | Asthma_Homo sapiens_hsa05310 | 0.76686336 |
| 62 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.76546988 |
| 63 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.69387467 |
| 64 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.67489089 |
| 65 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.66527030 |
| 66 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.66298221 |
| 67 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.65399613 |
| 68 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.64942621 |
| 69 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.63823787 |
| 70 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.63664923 |
| 71 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.62163914 |
| 72 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.60393007 |
| 73 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.60188885 |
| 74 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.59959274 |
| 75 | Retinol metabolism_Homo sapiens_hsa00830 | 0.59804625 |
| 76 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.59434471 |
| 77 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.58998728 |
| 78 | Taste transduction_Homo sapiens_hsa04742 | 0.55528185 |
| 79 | Olfactory transduction_Homo sapiens_hsa04740 | 0.54544466 |
| 80 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.53589022 |
| 81 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.52952869 |
| 82 | Metabolic pathways_Homo sapiens_hsa01100 | 0.51950506 |
| 83 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.51147516 |
| 84 | Measles_Homo sapiens_hsa05162 | 0.51003751 |
| 85 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.50692015 |
| 86 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.49901495 |
| 87 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.48327310 |
| 88 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.47870675 |
| 89 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.46658691 |
| 90 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.45490035 |
| 91 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.45126050 |
| 92 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.44002823 |
| 93 | Legionellosis_Homo sapiens_hsa05134 | 0.42320557 |
| 94 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.41761013 |
| 95 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.41368220 |
| 96 | Circadian rhythm_Homo sapiens_hsa04710 | 0.41126484 |
| 97 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.40253665 |
| 98 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.40023709 |
| 99 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.39855838 |
| 100 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.39809315 |
| 101 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.37601120 |
| 102 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.37562159 |
| 103 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.36890730 |
| 104 | Mineral absorption_Homo sapiens_hsa04978 | 0.34969512 |
| 105 | Shigellosis_Homo sapiens_hsa05131 | 0.34790840 |
| 106 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.34723668 |
| 107 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.33359145 |
| 108 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.32062667 |
| 109 | Nicotine addiction_Homo sapiens_hsa05033 | 0.30524178 |
| 110 | Apoptosis_Homo sapiens_hsa04210 | 0.30508803 |
| 111 | Other glycan degradation_Homo sapiens_hsa00511 | 0.30500356 |
| 112 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.30310445 |
| 113 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.29955309 |
| 114 | Leishmaniasis_Homo sapiens_hsa05140 | 0.27767737 |
| 115 | Malaria_Homo sapiens_hsa05144 | 0.25456269 |
| 116 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.20631580 |
| 117 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.20217481 |
| 118 | Pertussis_Homo sapiens_hsa05133 | 0.20118681 |
| 119 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.18814988 |
| 120 | HTLV-I infection_Homo sapiens_hsa05166 | 0.18809062 |
| 121 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.18154036 |
| 122 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.17289261 |
| 123 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.16301173 |
| 124 | Influenza A_Homo sapiens_hsa05164 | 0.16276728 |
| 125 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.13409986 |
| 126 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.13238331 |
| 127 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.12302880 |
| 128 | Phagosome_Homo sapiens_hsa04145 | 0.12015760 |
| 129 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.11781247 |
| 130 | Thyroid cancer_Homo sapiens_hsa05216 | 0.11289323 |
| 131 | Hepatitis B_Homo sapiens_hsa05161 | 0.10760865 |
| 132 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.10388367 |
| 133 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.09251677 |

