LMAN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.19314068
2COPI coating of Golgi vesicle (GO:0048205)6.19314068
3L-phenylalanine catabolic process (GO:0006559)5.89742946
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.89742946
5nuclear pore complex assembly (GO:0051292)5.68129476
6L-phenylalanine metabolic process (GO:0006558)5.65491090
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.65491090
8aromatic amino acid family catabolic process (GO:0009074)4.96624731
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.90877474
10nuclear pore organization (GO:0006999)4.88085550
11peptidyl-glutamic acid carboxylation (GO:0017187)4.76274058
12protein carboxylation (GO:0018214)4.76274058
13COPII vesicle coating (GO:0048208)4.73728474
14alpha-linolenic acid metabolic process (GO:0036109)4.54581354
15negative regulation of fibrinolysis (GO:0051918)4.53977660
16sulfur amino acid catabolic process (GO:0000098)4.49369132
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.45604297
18glyoxylate metabolic process (GO:0046487)4.38624412
19protein retention in ER lumen (GO:0006621)4.35311906
20cysteine metabolic process (GO:0006534)4.34536331
214-hydroxyproline metabolic process (GO:0019471)4.31434582
22intestinal cholesterol absorption (GO:0030299)4.28371644
23kynurenine metabolic process (GO:0070189)4.27324897
24regulation of fibrinolysis (GO:0051917)4.23692038
25lysine metabolic process (GO:0006553)4.22415256
26lysine catabolic process (GO:0006554)4.22415256
27regulation of protein activation cascade (GO:2000257)4.20813473
28homocysteine metabolic process (GO:0050667)4.20188714
29bile acid biosynthetic process (GO:0006699)4.19573991
30indole-containing compound catabolic process (GO:0042436)4.17878526
31indolalkylamine catabolic process (GO:0046218)4.17878526
32tryptophan catabolic process (GO:0006569)4.17878526
33tryptophan metabolic process (GO:0006568)4.17159076
34complement activation, alternative pathway (GO:0006957)4.14880731
35cell adhesion mediated by integrin (GO:0033627)4.08550799
36high-density lipoprotein particle remodeling (GO:0034375)4.08236550
37urea cycle (GO:0000050)4.07444512
38urea metabolic process (GO:0019627)4.07444512
39regulation of complement activation (GO:0030449)3.97836259
40pore complex assembly (GO:0046931)3.88271148
41activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.85470594
42bile acid metabolic process (GO:0008206)3.77115403
43reverse cholesterol transport (GO:0043691)3.76108445
44serine family amino acid catabolic process (GO:0009071)3.75388394
45tyrosine metabolic process (GO:0006570)3.73345546
46exocrine pancreas development (GO:0031017)3.72977518
47positive regulation of nuclease activity (GO:0032075)3.70599044
48triglyceride homeostasis (GO:0070328)3.69728157
49acylglycerol homeostasis (GO:0055090)3.69728157
50nitrogen cycle metabolic process (GO:0071941)3.69295221
51regulation of cholesterol homeostasis (GO:2000188)3.64924294
52cellular modified amino acid catabolic process (GO:0042219)3.62627108
53aromatic amino acid family metabolic process (GO:0009072)3.62502677
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.59681806
55protein-lipid complex remodeling (GO:0034368)3.53654190
56macromolecular complex remodeling (GO:0034367)3.53654190
57plasma lipoprotein particle remodeling (GO:0034369)3.53654190
58retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.53637262
59valine metabolic process (GO:0006573)3.52979388
60bile acid and bile salt transport (GO:0015721)3.52674027
61skin morphogenesis (GO:0043589)3.51762837
62glycine metabolic process (GO:0006544)3.51553582
63alpha-amino acid catabolic process (GO:1901606)3.45637092
64collagen fibril organization (GO:0030199)3.43120832
65endoplasmic reticulum unfolded protein response (GO:0030968)3.43063002
66regulation of translational fidelity (GO:0006450)3.42603977
67amino-acid betaine metabolic process (GO:0006577)3.40208371
68mitotic sister chromatid cohesion (GO:0007064)3.38807341
69plasma lipoprotein particle clearance (GO:0034381)3.38740573
70regulation of triglyceride catabolic process (GO:0010896)3.36860229
71regulation of nuclease activity (GO:0032069)3.35396420
72intestinal absorption (GO:0050892)3.32916694
73imidazole-containing compound metabolic process (GO:0052803)3.32372338
74endocrine pancreas development (GO:0031018)3.32036509
75coenzyme catabolic process (GO:0009109)3.32008076
76lipoprotein metabolic process (GO:0042157)3.31702104
77peptidyl-proline hydroxylation (GO:0019511)3.31519263
78positive regulation of fatty acid beta-oxidation (GO:0032000)3.31172367
79cellular response to unfolded protein (GO:0034620)3.31053605
80phospholipid efflux (GO:0033700)3.28845242
81cellular amino acid catabolic process (GO:0009063)3.27289376
82ER-nucleus signaling pathway (GO:0006984)3.24925024
83negative regulation of cholesterol transport (GO:0032375)3.23096836
84negative regulation of sterol transport (GO:0032372)3.23096836
85serine family amino acid metabolic process (GO:0009069)3.23076978
86mitotic chromosome condensation (GO:0007076)3.22414502
87nucleotide-sugar biosynthetic process (GO:0009226)3.20048112
88cellular glucuronidation (GO:0052695)3.18364325
89indolalkylamine metabolic process (GO:0006586)3.17817871
902-oxoglutarate metabolic process (GO:0006103)3.16792974
91protein hydroxylation (GO:0018126)3.16104925
92paraxial mesoderm development (GO:0048339)3.14259623
93DNA unwinding involved in DNA replication (GO:0006268)3.13020076
94endodermal cell differentiation (GO:0035987)3.12981480
95very-low-density lipoprotein particle assembly (GO:0034379)3.12628824
96tricarboxylic acid metabolic process (GO:0072350)3.11502852
97cellular response to topologically incorrect protein (GO:0035967)3.11318195
98fibrinolysis (GO:0042730)3.10111989
99drug transmembrane transport (GO:0006855)3.09812240
100regulation of cholesterol esterification (GO:0010872)3.09410648
101regulation of RNA export from nucleus (GO:0046831)3.07133881
102phospholipid homeostasis (GO:0055091)3.06878906
103serine family amino acid biosynthetic process (GO:0009070)3.04788722
104regulation of plasminogen activation (GO:0010755)3.04468756
105UDP-N-acetylglucosamine metabolic process (GO:0006047)3.04353163
106hemidesmosome assembly (GO:0031581)3.04198384
107plasma lipoprotein particle assembly (GO:0034377)3.04118907
108chondrocyte proliferation (GO:0035988)3.03807748
109benzene-containing compound metabolic process (GO:0042537)3.02982880
110cholesterol efflux (GO:0033344)3.02969407
111one-carbon metabolic process (GO:0006730)3.02408489
112proline biosynthetic process (GO:0006561)3.00295694
113glutamate metabolic process (GO:0006536)2.99429028
114epoxygenase P450 pathway (GO:0019373)2.98167498
115regulation of fatty acid beta-oxidation (GO:0031998)2.98073669
116ER overload response (GO:0006983)2.93682024
117vesicle coating (GO:0006901)2.92837619
118cholesterol homeostasis (GO:0042632)2.91689962
119* protein N-linked glycosylation via asparagine (GO:0018279)2.91269417
120sterol homeostasis (GO:0055092)2.90252630
121tetrahydrofolate metabolic process (GO:0046653)2.89708684
122fatty acid oxidation (GO:0019395)2.89621789
123folic acid-containing compound biosynthetic process (GO:0009396)2.89121219
124* peptidyl-asparagine modification (GO:0018196)2.88655969
125desmosome organization (GO:0002934)2.85809706
126negative regulation of DNA repair (GO:0045738)2.85526085
127midgut development (GO:0007494)2.81322856
128* protein N-linked glycosylation (GO:0006487)2.71848056
129ribosome assembly (GO:0042255)2.70863441
130regulation of transforming growth factor beta2 production (GO:0032909)2.70673305
131sequestering of extracellular ligand from receptor (GO:0035581)2.69838970
132mesodermal cell differentiation (GO:0048333)2.67697872
133regulation of mitotic spindle organization (GO:0060236)2.63366180
134chondrocyte development (GO:0002063)2.60901524
135protein maturation by protein folding (GO:0022417)2.58004619
136formation of translation preinitiation complex (GO:0001731)2.57564352
137regulation of nucleobase-containing compound transport (GO:0032239)2.54723095
138cell-substrate junction assembly (GO:0007044)2.51816527
139basement membrane organization (GO:0071711)2.50552178
140regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.50547230
141sister chromatid segregation (GO:0000819)2.49331348
142regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.49175311
143regulation of transforming growth factor beta1 production (GO:0032908)2.46639667
144protein localization to chromosome, centromeric region (GO:0071459)2.46255138
145positive regulation of hormone biosynthetic process (GO:0046886)2.45303398
146regulation of sister chromatid cohesion (GO:0007063)2.44829636
147regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.43842972
148cellular response to vitamin D (GO:0071305)2.43512049
149mitotic sister chromatid segregation (GO:0000070)2.42143599
150positive regulation of osteoblast proliferation (GO:0033690)2.39748652
151negative regulation of protein activation cascade (GO:2000258)2.38139155
152bundle of His cell to Purkinje myocyte communication (GO:0086069)2.36330738
153notochord development (GO:0030903)2.36225141
154establishment of apical/basal cell polarity (GO:0035089)2.35281875
155mitotic nuclear envelope disassembly (GO:0007077)2.34802694
156response to endoplasmic reticulum stress (GO:0034976)2.33513100
157cellular protein complex localization (GO:0034629)2.33273482
158retina vasculature morphogenesis in camera-type eye (GO:0061299)2.32855269
159apoptotic cell clearance (GO:0043277)2.32568568
160nucleobase-containing small molecule interconversion (GO:0015949)2.32050944
161positive regulation of endothelial cell apoptotic process (GO:2000353)2.31909878
162embryonic process involved in female pregnancy (GO:0060136)2.29358569
163mesenchymal-epithelial cell signaling (GO:0060638)2.27298723
164hyaluronan catabolic process (GO:0030214)2.26625022
165proline metabolic process (GO:0006560)2.25872427
166protein export from nucleus (GO:0006611)2.25041092
167endothelial cell morphogenesis (GO:0001886)2.24438276
168nuclear envelope disassembly (GO:0051081)2.23626192
169membrane disassembly (GO:0030397)2.23626192
170osteoblast differentiation (GO:0001649)2.23541349
171iron ion import (GO:0097286)2.22598336
172protein-lipid complex assembly (GO:0065005)2.21196627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.31315844
2E2F7_22180533_ChIP-Seq_HELA_Human6.80909480
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.65059661
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.83414444
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.33396141
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.20734459
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.67838050
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.95603204
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.92537812
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.73676981
11* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.26942483
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.12385470
13CLOCK_20551151_ChIP-Seq_293T_Human3.09235127
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.98168263
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.97657947
16GATA1_22025678_ChIP-Seq_K562_Human2.97132531
17* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.70020892
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.54111122
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.50600098
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50216204
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.38298431
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33059143
23* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26780181
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.16165077
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04082827
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86501220
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.81829086
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.79914801
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74022310
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71387802
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66173585
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.65854025
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.62977208
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.62608445
35* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62340141
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.60948359
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57824083
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.57803762
39* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55624833
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51725028
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51725028
42ELK1_19687146_ChIP-ChIP_HELA_Human1.44793888
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44470881
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.41593093
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41438813
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40223846
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39029685
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38335904
49EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.34333614
50GATA4_25053715_ChIP-Seq_YYC3_Human1.32992810
51HNF4A_19822575_ChIP-Seq_HepG2_Human1.29633570
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29431753
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29351432
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28996050
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28410071
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27549003
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21795974
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21347815
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18356341
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.17917111
61GATA6_25053715_ChIP-Seq_YYC3_Human1.16302076
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14602224
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13911155
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12459728
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12371699
66DCP1A_22483619_ChIP-Seq_HELA_Human1.10337885
67FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.10089861
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09420811
69* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09405938
70* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08435199
71* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07943954
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06725649
73AR_21909140_ChIP-Seq_LNCAP_Human1.06471110
74FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05941640
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05646683
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05596643
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.04684002
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04324990
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03751806
80GATA4_21415370_ChIP-Seq_HL-1_Mouse1.03629285
81CJUN_26792858_Chip-Seq_BT549_Human1.02449900
82MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02427672
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.02185691
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02103326
85CHD1_26751641_Chip-Seq_LNCaP_Human1.01116063
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.00595827
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99695916
88TCF4_18268006_ChIP-ChIP_LS174T_Human0.99668853
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98915580
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97763381
91GATA3_24758297_ChIP-Seq_MCF-7_Human0.97040989
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96645876
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96624242
94ZNF263_19887448_ChIP-Seq_K562_Human0.95549174
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94687022
96ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93936113
97SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93881747
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93138629
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92654615
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92513614
101* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91731080
102* ATF3_27146783_Chip-Seq_COLON_Human0.89882211
103HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88669784
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86793877
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86675373
106NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85535546
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85400521
108FOXA1_25552417_ChIP-Seq_VCAP_Human0.84913219
109ESR2_21235772_ChIP-Seq_MCF-7_Human0.84606805
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83363360
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83106396
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82855296
113PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82833955
114SOX2_20726797_ChIP-Seq_SW620_Human0.82655818
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82323072
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80954131
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79833835
118* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.78199316
119BRD4_25478319_ChIP-Seq_HGPS_Human0.78039733
120* TBX20_22328084_ChIP-Seq_HEART_Mouse0.77905524
121* TBX20_22080862_ChIP-Seq_HEART_Mouse0.77905524
122TFEB_21752829_ChIP-Seq_HELA_Human0.77309333
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76408211
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73650501
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73650501
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73583599
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72335045
128RACK7_27058665_Chip-Seq_MCF-7_Human0.72082018
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.70958702
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70553733
131IRF8_22096565_ChIP-ChIP_GC-B_Human0.69260411
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69180020
133RXRA_24833708_ChIP-Seq_LIVER_Mouse0.68865093
134GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.68302012
135P300_27058665_Chip-Seq_ZR-75-30cells_Human0.68206795
136* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66354030
137ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.65820594
138CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.64911919
139RARA_24833708_ChIP-Seq_LIVER_Mouse0.64207558
140GATA1_19941826_ChIP-Seq_K562_Human0.62786298
141NCOR1_26117541_ChIP-Seq_K562_Human0.61677340
142LXR_22292898_ChIP-Seq_THP-1_Human0.61633664
143SOX17_20123909_ChIP-Seq_XEN_Mouse0.61132589
144SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60570488
145ERG_20517297_ChIP-Seq_VCAP_Human0.60307527
146HTT_18923047_ChIP-ChIP_STHdh_Human0.60085359
147* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.58760921
148PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58698356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.96910959
2MP0005360_urolithiasis4.99996899
3MP0005365_abnormal_bile_salt4.86454848
4MP0005085_abnormal_gallbladder_physiolo4.56621659
5MP0003252_abnormal_bile_duct3.57790822
6MP0003195_calcinosis3.06146744
7MP0008875_abnormal_xenobiotic_pharmacok3.05756152
8MP0003806_abnormal_nucleotide_metabolis3.05743638
9MP0003941_abnormal_skin_development2.77520725
10MP0005083_abnormal_biliary_tract2.73913443
11MP0003705_abnormal_hypodermis_morpholog2.69956686
12MP0001666_abnormal_nutrient_absorption2.65140024
13MP0010329_abnormal_lipoprotein_level2.44615621
14MP0003950_abnormal_plasma_membrane2.37407598
15MP0008438_abnormal_cutaneous_collagen2.34488888
16MP0002877_abnormal_melanocyte_morpholog2.33359581
17MP0005220_abnormal_exocrine_pancreas2.31948350
18MP0009840_abnormal_foam_cell2.20591132
19MP0003868_abnormal_feces_composition2.15696715
20MP0004957_abnormal_blastocyst_morpholog1.98090401
21MP0003283_abnormal_digestive_organ1.90387282
22MP0005332_abnormal_amino_acid1.89601888
23MP0006054_spinal_hemorrhage1.77083398
24MP0001944_abnormal_pancreas_morphology1.72920275
25MP0005623_abnormal_meninges_morphology1.72649691
26MP0000609_abnormal_liver_physiology1.69690281
27MP0002138_abnormal_hepatobiliary_system1.68729909
28MP0008057_abnormal_DNA_replication1.63635463
29MP0009780_abnormal_chondrocyte_physiolo1.59913442
30MP0002118_abnormal_lipid_homeostasis1.55785744
31MP0004264_abnormal_extraembryonic_tissu1.51414959
32MP0002693_abnormal_pancreas_physiology1.50189176
33MP0003111_abnormal_nucleus_morphology1.43090310
34MP0009643_abnormal_urine_homeostasis1.42586449
35MP0003300_gastrointestinal_ulcer1.39726460
36MP0003091_abnormal_cell_migration1.38533302
37MP0005319_abnormal_enzyme/_coenzyme1.34518573
38MP0001730_embryonic_growth_arrest1.34285430
39MP0004019_abnormal_vitamin_homeostasis1.32678833
40MP0003693_abnormal_embryo_hatching1.32146850
41MP0003191_abnormal_cellular_cholesterol1.30658020
42MP0009384_cardiac_valve_regurgitation1.30550617
43MP0002078_abnormal_glucose_homeostasis1.30347543
44MP0002896_abnormal_bone_mineralization1.28956876
45MP0005275_abnormal_skin_tensile1.28228419
46MP0008932_abnormal_embryonic_tissue1.26778071
47MP0001299_abnormal_eye_distance/1.25565048
48MP0010368_abnormal_lymphatic_system1.23076187
49MP0000013_abnormal_adipose_tissue1.22261733
50MP0004043_abnormal_pH_regulation1.22082707
51MP0003890_abnormal_embryonic-extraembry1.21862202
52MP0001958_emphysema1.20703758
53MP0003984_embryonic_growth_retardation1.19748971
54MP0010094_abnormal_chromosome_stability1.19099096
55MP0002086_abnormal_extraembryonic_tissu1.18050851
56MP0001672_abnormal_embryogenesis/_devel1.17597357
57MP0005380_embryogenesis_phenotype1.17597357
58MP0010234_abnormal_vibrissa_follicle1.17578157
59MP0003385_abnormal_body_wall1.16217215
60MP0002088_abnormal_embryonic_growth/wei1.14953992
61MP0002084_abnormal_developmental_patter1.13560593
62MP0002928_abnormal_bile_duct1.13007241
63MP0000762_abnormal_tongue_morphology1.12452480
64MP0000598_abnormal_liver_morphology1.10428898
65MP0003077_abnormal_cell_cycle1.10329107
66MP0010030_abnormal_orbit_morphology1.09086724
67MP0002396_abnormal_hematopoietic_system1.08367909
68MP0001697_abnormal_embryo_size1.08236898
69MP0002837_dystrophic_cardiac_calcinosis1.07390259
70MP0002909_abnormal_adrenal_gland1.07273900
71MP0002697_abnormal_eye_size1.07170124
72MP0010307_abnormal_tumor_latency1.06228801
73MP0000350_abnormal_cell_proliferation1.06182844
74MP0004233_abnormal_muscle_weight1.05912400
75MP0000428_abnormal_craniofacial_morphol1.05694298
76MP0004272_abnormal_basement_membrane1.04919617
77MP0005503_abnormal_tendon_morphology1.02728824
78MP0003937_abnormal_limbs/digits/tail_de1.00487467
79MP0009053_abnormal_anal_canal1.00286003
80MP0001764_abnormal_homeostasis0.99682864
81MP0008007_abnormal_cellular_replicative0.98669418
82MP0003942_abnormal_urinary_system0.97821196
83MP0005408_hypopigmentation0.97653816
84MP0004134_abnormal_chest_morphology0.95811951
85MP0010352_gastrointestinal_tract_polyps0.95537891
86MP0002085_abnormal_embryonic_tissue0.94570524
87MP0002080_prenatal_lethality0.92950210
88MP0003566_abnormal_cell_adhesion0.92764816
89MP0005084_abnormal_gallbladder_morpholo0.91136361
90MP0005197_abnormal_uvea_morphology0.90808219
91MP0002060_abnormal_skin_morphology0.88180215
92MP0005409_darkened_coat_color0.87441190
93MP0000003_abnormal_adipose_tissue0.85991715
94MP0002108_abnormal_muscle_morphology0.84665018
95MP0009672_abnormal_birth_weight0.84499717
96MP0000432_abnormal_head_morphology0.84372211
97MP0005636_abnormal_mineral_homeostasis0.82795788
98MP0000767_abnormal_smooth_muscle0.82439661
99MP0004782_abnormal_surfactant_physiolog0.81559128
100MP0000678_abnormal_parathyroid_gland0.81257891
101MP0001756_abnormal_urination0.81233508
102MP0002009_preneoplasia0.81036362
103MP0000733_abnormal_muscle_development0.79862345
104MP0005670_abnormal_white_adipose0.79354303
105MP0001879_abnormal_lymphatic_vessel0.79143057
106MP0005248_abnormal_Harderian_gland0.78297095
107MP0005076_abnormal_cell_differentiation0.78027497
108MP0005621_abnormal_cell_physiology0.77816257
109MP0002092_abnormal_eye_morphology0.77721368
110MP0004197_abnormal_fetal_growth/weight/0.76488346
111MP0003186_abnormal_redox_activity0.75331374
112MP0009697_abnormal_copulation0.74631173
113MP0003453_abnormal_keratinocyte_physiol0.74361737
114MP0001849_ear_inflammation0.74048960
115MP0009250_abnormal_appendicular_skeleto0.73789400
116MP0003123_paternal_imprinting0.73663778
117MP0005584_abnormal_enzyme/coenzyme_acti0.73522056
118MP0005023_abnormal_wound_healing0.73435893
119MP0003959_abnormal_lean_body0.73411887
120MP0000537_abnormal_urethra_morphology0.73036380
121MP0003935_abnormal_craniofacial_develop0.72985315
122MP0002089_abnormal_postnatal_growth/wei0.72387037
123MP0002938_white_spotting0.72139893
124MP0002925_abnormal_cardiovascular_devel0.71979647
125MP0009642_abnormal_blood_homeostasis0.71795110
126MP0002128_abnormal_blood_circulation0.71768867
127MP0005058_abnormal_lysosome_morphology0.71239477
128MP0000534_abnormal_ureter_morphology0.70874764
129MP0005187_abnormal_penis_morphology0.70681775
130MP0005666_abnormal_adipose_tissue0.70494293
131MP0002168_other_aberrant_phenotype0.69767626
132MP0005334_abnormal_fat_pad0.69090222
133MP0005257_abnormal_intraocular_pressure0.68664565
134MP0005375_adipose_tissue_phenotype0.66154349
135MP0001661_extended_life_span0.66075567
136MP0004185_abnormal_adipocyte_glucose0.64825752
137MP0000639_abnormal_adrenal_gland0.64807275
138MP0000613_abnormal_salivary_gland0.64510497
139MP0001243_abnormal_dermal_layer0.62538248
140MP0000163_abnormal_cartilage_morphology0.62192991
141MP0003953_abnormal_hormone_level0.61996068
142MP0009763_increased_sensitivity_to0.61157135
143MP0002295_abnormal_pulmonary_circulatio0.60872736
144MP0005379_endocrine/exocrine_gland_phen0.60834007
145MP0003279_aneurysm0.60774264
146MP0002254_reproductive_system_inflammat0.56437384
147MP0000462_abnormal_digestive_system0.56127787
148MP0005448_abnormal_energy_balance0.55583251
149MP0003183_abnormal_peptide_metabolism0.54302707
150MP0008961_abnormal_basal_metabolism0.51788940
151MP0002971_abnormal_brown_adipose0.51640367
152MP0003011_delayed_dark_adaptation0.51582405
153MP0003656_abnormal_erythrocyte_physiolo0.51277008
154MP0005647_abnormal_sex_gland0.50945823
155MP0005508_abnormal_skeleton_morphology0.50300913
156MP0001915_intracranial_hemorrhage0.49628974
157MP0002269_muscular_atrophy0.49535386
158MP0001765_abnormal_ion_homeostasis0.49036710
159MP0001881_abnormal_mammary_gland0.48199727
160MP0009703_decreased_birth_body0.47663259

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.83231369
2Hypoglycemic coma (HP:0001325)5.73976365
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.53483417
4Deep venous thrombosis (HP:0002625)5.32450984
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.12926828
6Hypoglycemic seizures (HP:0002173)4.81364012
7Xanthomatosis (HP:0000991)4.77654766
8Hyperinsulinemic hypoglycemia (HP:0000825)4.75336589
9Hypobetalipoproteinemia (HP:0003563)4.42871147
10Prolonged partial thromboplastin time (HP:0003645)4.31372862
11Ketoacidosis (HP:0001993)4.03097973
12Ketosis (HP:0001946)4.00087522
13* Abnormality of the intrinsic pathway (HP:0010989)3.82354119
14* Abnormality of the common coagulation pathway (HP:0010990)3.79940503
15Complement deficiency (HP:0004431)3.72149611
16Symptomatic seizures (HP:0011145)3.67611246
17Hyperglycemia (HP:0003074)3.62859407
18Hypolipoproteinemia (HP:0010981)3.58249563
19Aortic dissection (HP:0002647)3.58211159
20Arterial tortuosity (HP:0005116)3.57988336
21Fat malabsorption (HP:0002630)3.46341839
22Conjugated hyperbilirubinemia (HP:0002908)3.46218950
23Vascular tortuosity (HP:0004948)3.42928810
24Epidermoid cyst (HP:0200040)3.37453448
25Hyperlipoproteinemia (HP:0010980)3.36482914
26Abnormality of endocrine pancreas physiology (HP:0012093)3.35665674
27Abnormality of the pancreatic islet cells (HP:0006476)3.35665674
28Hypoalphalipoproteinemia (HP:0003233)3.27525214
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.17381067
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.15308605
31Late onset (HP:0003584)3.15271296
32Skin nodule (HP:0200036)3.10464153
33Abnormality of glutamine family amino acid metabolism (HP:0010902)3.03843406
34Pancreatic islet-cell hyperplasia (HP:0004510)3.02239440
35Hyperammonemia (HP:0001987)3.02036343
36Soft skin (HP:0000977)3.00701659
37Joint hemorrhage (HP:0005261)2.93202718
38Atrophic scars (HP:0001075)2.93074347
39Hyperglycinemia (HP:0002154)2.91766967
40Ankyloglossia (HP:0010296)2.90773577
41Wormian bones (HP:0002645)2.85265008
42Abnormality of dentin (HP:0010299)2.83811847
43Abnormality of complement system (HP:0005339)2.79940846
44Bladder diverticulum (HP:0000015)2.76384011
45Abnormality of methionine metabolism (HP:0010901)2.74228681
46Hyperglycinuria (HP:0003108)2.73902394
47Follicular hyperkeratosis (HP:0007502)2.72314137
48Hepatocellular carcinoma (HP:0001402)2.70081271
49Generalized aminoaciduria (HP:0002909)2.69429082
50Protrusio acetabuli (HP:0003179)2.68345926
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.67027669
52Vertebral compression fractures (HP:0002953)2.64665628
53Abnormality of purine metabolism (HP:0004352)2.63252470
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.61104784
55Osteolytic defects of the hand bones (HP:0009699)2.61104784
56Ankle contracture (HP:0006466)2.60961513
57Abnormality of serine family amino acid metabolism (HP:0010894)2.57664126
58Abnormality of glycine metabolism (HP:0010895)2.57664126
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.57541803
60Fragile skin (HP:0001030)2.57007047
61Aortic aneurysm (HP:0004942)2.56385013
62Hyperbilirubinemia (HP:0002904)2.56266966
63Neonatal short-limb short stature (HP:0008921)2.53401815
64Abnormality of the acetabulum (HP:0003170)2.51407729
65Abnormality of oral frenula (HP:0000190)2.48451874
66Asymmetry of the thorax (HP:0001555)2.47733544
67Abnormal delivery (HP:0001787)2.47091194
68Abnormality of nucleobase metabolism (HP:0010932)2.43958871
69Gout (HP:0001997)2.43813813
70Flat acetabular roof (HP:0003180)2.43543561
71Insulin-resistant diabetes mellitus (HP:0000831)2.42911149
72Myocardial infarction (HP:0001658)2.40344733
73Abnormality of fatty-acid metabolism (HP:0004359)2.39038519
74Back pain (HP:0003418)2.38886268
75Protuberant abdomen (HP:0001538)2.35960024
76Insulin resistance (HP:0000855)2.34937433
77Hypercholesterolemia (HP:0003124)2.31855151
78Mitral valve prolapse (HP:0001634)2.31425903
79Abnormal cartilage morphology (HP:0002763)2.29973679
80Steatorrhea (HP:0002570)2.29210226
81Abnormality of carpal bone ossification (HP:0006257)2.26951845
82Blue sclerae (HP:0000592)2.25573192
83Premature rupture of membranes (HP:0001788)2.23183856
84Mucopolysacchariduria (HP:0008155)2.21873421
85Urinary glycosaminoglycan excretion (HP:0003541)2.21873421
86Relative macrocephaly (HP:0004482)2.19196679
87Overlapping toe (HP:0001845)2.14145050
88Enlarged kidneys (HP:0000105)2.12388120
89Hyperextensible skin (HP:0000974)2.12286776
90Renal duplication (HP:0000075)2.09231819
91Abnormal enzyme/coenzyme activity (HP:0012379)2.08966604
92Spastic diplegia (HP:0001264)2.08186637
93Mitral stenosis (HP:0001718)2.07003805
94Breech presentation (HP:0001623)2.05454432
95Abnormality of pyrimidine metabolism (HP:0004353)2.05371672
96Cervical subluxation (HP:0003308)2.04251954
97Biconcave vertebral bodies (HP:0004586)2.03046774
98Cupped ribs (HP:0000887)2.01888552
99Abdominal distention (HP:0003270)2.01323296
100Elevated alkaline phosphatase (HP:0003155)1.99637224
101Right ventricular cardiomyopathy (HP:0011663)1.99468410
102Dilatation of the ascending aorta (HP:0005111)1.97794921
103Abnormality of alkaline phosphatase activity (HP:0004379)1.96583565
104Esophageal varix (HP:0002040)1.95566546
105Ulnar bowing (HP:0003031)1.94383014
106Elbow flexion contracture (HP:0002987)1.93937153
107Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93322084
108Abnormality of polysaccharide metabolism (HP:0011012)1.93322084
109Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93322084
110Broad palm (HP:0001169)1.91864709
111Coronal craniosynostosis (HP:0004440)1.90008818
112Hypochromic microcytic anemia (HP:0004840)1.89787062
113Orthostatic hypotension (HP:0001278)1.89759988
114Abnormal ossification of hand bones (HP:0005921)1.89244816
115Turricephaly (HP:0000262)1.88993202
116Spondylolisthesis (HP:0003302)1.88984387
117Delayed CNS myelination (HP:0002188)1.88952648
118Hydroxyprolinuria (HP:0003080)1.86497102
119Abnormality of proline metabolism (HP:0010907)1.86497102
120Disproportionate tall stature (HP:0001519)1.86403351
121Pancreatitis (HP:0001733)1.85082371
122Abnormal tarsal ossification (HP:0008369)1.85071075
123Aneurysm (HP:0002617)1.84930582
124Overgrowth (HP:0001548)1.84793155
125Shallow orbits (HP:0000586)1.83572167
126Cerebral aneurysm (HP:0004944)1.83156880
127Peritonitis (HP:0002586)1.82651343
128Syringomyelia (HP:0003396)1.81678871
129Spinal cord lesions (HP:0100561)1.81678871
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80894280
131Wide nose (HP:0000445)1.80749516
132Proximal tubulopathy (HP:0000114)1.80285385
133Joint laxity (HP:0001388)1.79835818
134Nonimmune hydrops fetalis (HP:0001790)1.79412473
135Metabolic acidosis (HP:0001942)1.79370464
136Cardiovascular calcification (HP:0011915)1.79112118
137Deep philtrum (HP:0002002)1.78073582
138Small epiphyses (HP:0010585)1.77633074
139Abnormal foot bone ossification (HP:0010675)1.77357875
140Microglossia (HP:0000171)1.76240435
141Rhizomelia (HP:0008905)1.76182313
142Irritability (HP:0000737)1.75888326
143Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75839756
144Dicarboxylic aciduria (HP:0003215)1.75839756
145Menorrhagia (HP:0000132)1.75440266
146Vertebral arch anomaly (HP:0008438)1.75271688
147Spinal rigidity (HP:0003306)1.74970063
148Abnormal gallbladder morphology (HP:0012437)1.74724792
149Increased nuchal translucency (HP:0010880)1.74467848
150Short nail (HP:0001799)1.73716382
151Abnormal pancreas size (HP:0012094)1.73592454
152Lymphangioma (HP:0100764)1.73544685
153Thoracolumbar scoliosis (HP:0002944)1.73396263
154Abnormality of serum amino acid levels (HP:0003112)1.73047009
155Abnormal hand bone ossification (HP:0010660)1.72624028
156Bowel diverticulosis (HP:0005222)1.72465144
157Natal tooth (HP:0000695)1.72325552
158Pterygium (HP:0001059)1.72151701
159Delayed closure of the anterior fontanelle (HP:0001476)1.71329313
160Papillary thyroid carcinoma (HP:0002895)1.70133205
161Acanthocytosis (HP:0001927)1.68729380
162Ectopia lentis (HP:0001083)1.67909150
163Tetraparesis (HP:0002273)1.67602985
164Advanced eruption of teeth (HP:0006288)1.67388778
165Coxa vara (HP:0002812)1.67049919
166Glomerulonephritis (HP:0000099)1.66183498
167Abnormality of glycolysis (HP:0004366)1.65363684
168Limited elbow extension (HP:0001377)1.65315063
169Vascular calcification (HP:0004934)1.65178423
170Retinal atrophy (HP:0001105)1.64983779
171Mildly elevated creatine phosphokinase (HP:0008180)1.64365448
172Neonatal death (HP:0003811)1.63838101
173Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62681271
174Delayed cranial suture closure (HP:0000270)1.62335235
175Abnormality of the calcaneus (HP:0008364)1.61215384
176Inguinal hernia (HP:0000023)1.61199415
177Type 1 muscle fiber predominance (HP:0003803)1.60469893
178Missing ribs (HP:0000921)1.60144621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.30816044
2INSRR4.18201605
3BCKDK3.71944375
4TAOK33.60815045
5SIK13.34803126
6FRK3.13560811
7TRIB33.11182878
8PKN23.07629148
9FLT32.86639881
10LATS12.84725008
11PASK2.81099987
12EIF2AK12.75699356
13TTK2.33943708
14PTK62.19799636
15PDGFRA2.07442873
16PBK2.00274113
17FGFR41.99751674
18ICK1.85392891
19SCYL21.81266467
20CDC71.64463218
21MAPK151.51467794
22TRPM71.44402884
23TSSK61.44155093
24MET1.41061329
25MAP3K101.39545727
26PIK3CG1.38578609
27EPHA31.35067334
28PTK21.33523448
29DDR21.30944550
30NEK91.28933979
31SMG11.24961293
32MAP3K21.24141371
33MYLK1.21925413
34RIPK11.19839151
35STK241.18205664
36MAP3K31.17828568
37MKNK11.17247280
38HIPK21.16826788
39SRPK11.09937017
40PLK31.06794025
41WEE11.05652203
42ERBB41.05588257
43DYRK1B1.05038445
44BRSK21.03520478
45EPHA21.02887476
46TTN1.01792018
47MTOR1.01085880
48CDK70.93433212
49PRKD30.93234906
50EIF2AK30.91104423
51STK30.90421934
52NEK20.90000247
53JAK20.89804876
54CLK10.88271928
55FER0.86216102
56CDK60.84935728
57MST1R0.84854845
58PAK20.83800930
59STK38L0.83443060
60MST40.83185830
61KDR0.83108960
62EEF2K0.82253182
63MAP2K30.81327391
64MAPK110.78769271
65CHEK10.78024102
66LRRK20.76987889
67PDK20.76923820
68CAMK1D0.75017152
69BRAF0.74158824
70NUAK10.74110174
71JAK10.73869425
72PNCK0.72681702
73BRSK10.71281287
74TGFBR20.71040292
75WNK10.70729231
76GSK3A0.70412878
77CDK80.70261479
78RET0.69824711
79PAK30.69738727
80CDK120.69294827
81FGFR30.68178349
82MKNK20.68055705
83IRAK30.67030358
84MAP3K10.66972013
85CHEK20.66171184
86BUB10.64544024
87AURKB0.64349669
88CDC42BPA0.64097872
89RPS6KA40.61785396
90KSR20.59897890
91TAF10.59677402
92TGFBR10.58005808
93BCR0.57874547
94PDGFRB0.57258930
95ATM0.57223139
96WNK40.56621214
97FGFR10.56235493
98MAP2K20.55581233
99PLK40.55387672
100ERBB30.55165704
101EIF2AK20.55031650
102PRKAA10.54973880
103TYK20.54467812
104PRKAA20.54003274
105NLK0.53714488
106ERBB20.53552940
107PLK10.53440726
108AKT30.52975639
109STK40.49033573
110IGF1R0.48405685
111CDK90.47164819
112MAP3K90.46636689
113MAP3K80.45454377
114ACVR1B0.45182103
115PIK3CA0.44898473
116KSR10.44739077
117FGFR20.44677201
118CSNK1E0.44434723
119RPS6KB20.43962393
120DMPK0.43608153
121MAP3K120.43208480
122PRKCH0.42459809
123ALK0.41406762
124MAP3K130.41062204
125PAK40.40268725
126AKT20.40173977
127LMTK20.39257265
128CDK10.39233561
129JAK30.38579018
130MAPKAPK30.37565796
131ABL20.36863765
132EPHB10.35074541
133CHUK0.34345450
134MAP2K10.34204252
135PRKD10.34109057
136BMX0.33904260
137PRKACG0.33413730
138BRD40.30490883
139NTRK10.29278436
140MELK0.27157019
141ZAP700.26250378
142CDK40.25968417
143EGFR0.25456493
144RPS6KB10.24854939
145IRAK10.23925161
146TIE10.23805990
147CAMK1G0.23340363
148LATS20.22404578
149NEK10.22303398
150MAP3K50.21651410

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.22325130
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.61975130
3Nitrogen metabolism_Homo sapiens_hsa009103.18959241
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.03892313
5Tryptophan metabolism_Homo sapiens_hsa003802.71422966
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.66142172
7Selenocompound metabolism_Homo sapiens_hsa004502.50660836
8Arginine biosynthesis_Homo sapiens_hsa002202.40697898
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40634039
10Fatty acid degradation_Homo sapiens_hsa000712.38454152
11Sulfur metabolism_Homo sapiens_hsa009202.37008386
12Complement and coagulation cascades_Homo sapiens_hsa046102.33749471
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17203777
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12816880
15Protein export_Homo sapiens_hsa030601.94506291
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.93575809
17* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.85717477
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.81808758
19Butanoate metabolism_Homo sapiens_hsa006501.72211084
20Propanoate metabolism_Homo sapiens_hsa006401.66426006
21Peroxisome_Homo sapiens_hsa041461.64858450
22Fat digestion and absorption_Homo sapiens_hsa049751.61069247
23Fatty acid metabolism_Homo sapiens_hsa012121.60853067
24Starch and sucrose metabolism_Homo sapiens_hsa005001.59230911
25Thyroid cancer_Homo sapiens_hsa052161.59132964
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.58324943
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55493342
28Histidine metabolism_Homo sapiens_hsa003401.54140462
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51461679
30Folate biosynthesis_Homo sapiens_hsa007901.51414673
31Small cell lung cancer_Homo sapiens_hsa052221.51225932
32Caffeine metabolism_Homo sapiens_hsa002321.49659424
33PPAR signaling pathway_Homo sapiens_hsa033201.48868535
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44609491
35Cell cycle_Homo sapiens_hsa041101.41685682
36Phenylalanine metabolism_Homo sapiens_hsa003601.40320767
37Chemical carcinogenesis_Homo sapiens_hsa052041.40071629
38Non-homologous end-joining_Homo sapiens_hsa034501.39684963
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37874303
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37855049
41Vitamin B6 metabolism_Homo sapiens_hsa007501.37840951
42One carbon pool by folate_Homo sapiens_hsa006701.37276043
43Proteoglycans in cancer_Homo sapiens_hsa052051.31225460
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.30914595
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29479217
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28754372
47beta-Alanine metabolism_Homo sapiens_hsa004101.28231762
48RNA transport_Homo sapiens_hsa030131.27722964
49ABC transporters_Homo sapiens_hsa020101.26810292
50Lysine degradation_Homo sapiens_hsa003101.24128665
51Bile secretion_Homo sapiens_hsa049761.22151295
52Tyrosine metabolism_Homo sapiens_hsa003501.17622472
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16808215
54DNA replication_Homo sapiens_hsa030301.16278871
55TGF-beta signaling pathway_Homo sapiens_hsa043501.15240320
56Retinol metabolism_Homo sapiens_hsa008301.13736311
57Pyruvate metabolism_Homo sapiens_hsa006201.13618178
58Staphylococcus aureus infection_Homo sapiens_hsa051501.12965825
59Nucleotide excision repair_Homo sapiens_hsa034201.12344848
60Mismatch repair_Homo sapiens_hsa034301.11671954
61Biosynthesis of amino acids_Homo sapiens_hsa012301.11217033
62MicroRNAs in cancer_Homo sapiens_hsa052061.08404831
63Carbon metabolism_Homo sapiens_hsa012001.05589501
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98129276
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.97768824
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97266923
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97035493
68Chronic myeloid leukemia_Homo sapiens_hsa052200.93864366
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92763590
70Pancreatic cancer_Homo sapiens_hsa052120.92579295
71Arginine and proline metabolism_Homo sapiens_hsa003300.90936411
72mRNA surveillance pathway_Homo sapiens_hsa030150.89799927
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88333231
74N-Glycan biosynthesis_Homo sapiens_hsa005100.87735943
75Galactose metabolism_Homo sapiens_hsa000520.82317306
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81890351
77p53 signaling pathway_Homo sapiens_hsa041150.81566383
78Insulin resistance_Homo sapiens_hsa049310.81524241
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80705883
80Hippo signaling pathway_Homo sapiens_hsa043900.79615464
81Sphingolipid metabolism_Homo sapiens_hsa006000.77267884
82Vitamin digestion and absorption_Homo sapiens_hsa049770.76181957
83Fatty acid elongation_Homo sapiens_hsa000620.73322667
84Protein digestion and absorption_Homo sapiens_hsa049740.72987245
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72158283
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70520129
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69837096
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69490662
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.68705242
90Steroid biosynthesis_Homo sapiens_hsa001000.68075170
91Sulfur relay system_Homo sapiens_hsa041220.60763221
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60659720
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60231691
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.58631163
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57654559
96Glycerolipid metabolism_Homo sapiens_hsa005610.57047715
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57032958
98Renal cell carcinoma_Homo sapiens_hsa052110.56979189
99Spliceosome_Homo sapiens_hsa030400.55304331
100Tight junction_Homo sapiens_hsa045300.54581691
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54450809
102HIF-1 signaling pathway_Homo sapiens_hsa040660.53128210
103Prion diseases_Homo sapiens_hsa050200.52968640
104Melanoma_Homo sapiens_hsa052180.51446717
105Glucagon signaling pathway_Homo sapiens_hsa049220.50184329
106Pathways in cancer_Homo sapiens_hsa052000.48845975
107Non-small cell lung cancer_Homo sapiens_hsa052230.46723000
108Glutathione metabolism_Homo sapiens_hsa004800.46467261
109mTOR signaling pathway_Homo sapiens_hsa041500.45104933
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44657308
111Type II diabetes mellitus_Homo sapiens_hsa049300.41153070
112Pentose phosphate pathway_Homo sapiens_hsa000300.38484626
113Bladder cancer_Homo sapiens_hsa052190.38409556
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38210915
115ECM-receptor interaction_Homo sapiens_hsa045120.36630188
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36043381
117Metabolic pathways_Homo sapiens_hsa011000.33823905
118Fructose and mannose metabolism_Homo sapiens_hsa000510.33630939
119Lysosome_Homo sapiens_hsa041420.32355413
120AMPK signaling pathway_Homo sapiens_hsa041520.31656594
121Thyroid hormone synthesis_Homo sapiens_hsa049180.30393363
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.28629977
123Renin-angiotensin system_Homo sapiens_hsa046140.28560464
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25533409
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.22996896
126Insulin secretion_Homo sapiens_hsa049110.22993588
127Other glycan degradation_Homo sapiens_hsa005110.22022347
128Linoleic acid metabolism_Homo sapiens_hsa005910.21986625
129Insulin signaling pathway_Homo sapiens_hsa049100.19129207
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16114559
131Pancreatic secretion_Homo sapiens_hsa049720.15465003
132Fatty acid biosynthesis_Homo sapiens_hsa000610.14755114
133Focal adhesion_Homo sapiens_hsa045100.14024644
134Amoebiasis_Homo sapiens_hsa051460.13412240
135Adherens junction_Homo sapiens_hsa045200.09468021
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.07879286
137Prostate cancer_Homo sapiens_hsa052150.06539275

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