LMAN1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mannose-binding type 1 transmembrane protein that contains an N-terminal lectin-like carbohydrate recognition domain. The encoded protein is similar in structure to lectins found in leguminous plants. This lectin is thought to transport newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)9.37378211
2detection of light stimulus involved in visual perception (GO:0050908)9.37378211
3retinal rod cell development (GO:0046548)8.53788170
4response to pheromone (GO:0019236)7.71044586
5negative regulation of cytosolic calcium ion concentration (GO:0051481)7.11371582
6cellular potassium ion homeostasis (GO:0030007)6.33877504
7G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.08117573
8sodium ion export (GO:0071436)5.90959623
9relaxation of smooth muscle (GO:0044557)5.51779088
10positive regulation of synapse maturation (GO:0090129)5.38260894
11urinary tract smooth muscle contraction (GO:0014848)5.32399019
12potassium ion homeostasis (GO:0055075)5.20896291
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.83331155
14tachykinin receptor signaling pathway (GO:0007217)4.80296800
15regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.75740955
16keratinization (GO:0031424)4.64997888
17synaptic vesicle exocytosis (GO:0016079)4.59935300
18regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.57370521
19cardiac muscle contraction (GO:0060048)4.51562479
20positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.46717452
21glutamate secretion (GO:0014047)4.40061169
22synaptic vesicle maturation (GO:0016188)4.35123068
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.31848151
24negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.31583122
25regulation of synaptic vesicle transport (GO:1902803)4.31146504
26somite rostral/caudal axis specification (GO:0032525)4.26314867
27regulation of actin filament-based movement (GO:1903115)4.21277580
28photoreceptor cell development (GO:0042461)4.16542739
29eye photoreceptor cell development (GO:0042462)4.13499469
30cardiac muscle hypertrophy (GO:0003300)4.05519924
31potassium ion export (GO:0071435)4.04383323
32cell communication by electrical coupling (GO:0010644)4.02619128
33regulation of synapse maturation (GO:0090128)3.97719052
34detection of calcium ion (GO:0005513)3.96196128
35retinal cone cell development (GO:0046549)3.94318915
36glycolytic process (GO:0006096)3.93839380
37neuronal ion channel clustering (GO:0045161)3.93589051
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.91739446
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.89817046
40cerebellar granule cell differentiation (GO:0021707)3.89215641
41regulation of cell communication by electrical coupling (GO:0010649)3.84787893
42potassium ion import (GO:0010107)3.82151734
43striated muscle hypertrophy (GO:0014897)3.81191917
44regulation of cardiac muscle cell contraction (GO:0086004)3.79650550
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.78052556
46protein localization to synapse (GO:0035418)3.77111215
47regulation of voltage-gated calcium channel activity (GO:1901385)3.65647056
48sarcomere organization (GO:0045214)3.64213469
49synaptic vesicle endocytosis (GO:0048488)3.60284868
50muscle hypertrophy (GO:0014896)3.58478079
51calcium ion import (GO:0070509)3.56510741
52primitive streak formation (GO:0090009)3.55727583
53positive regulation of gastrulation (GO:2000543)3.54644542
54peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.52986636
55positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.50284446
56photoreceptor cell maintenance (GO:0045494)3.49830934
57negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.47002164
58cardiac conduction (GO:0061337)3.46175636
59membrane repolarization (GO:0086009)3.45007947
60cardiac muscle hypertrophy in response to stress (GO:0014898)3.42401880
61muscle hypertrophy in response to stress (GO:0003299)3.42401880
62cardiac muscle adaptation (GO:0014887)3.42401880
63locomotory exploration behavior (GO:0035641)3.42235055
64innervation (GO:0060384)3.38988560
65sensory perception of light stimulus (GO:0050953)3.36274889
66regulation of relaxation of muscle (GO:1901077)3.36272332
67activation of protein kinase A activity (GO:0034199)3.36132944
68neurotransmitter secretion (GO:0007269)3.35478284
69visual perception (GO:0007601)3.34998576
70regulation of ARF protein signal transduction (GO:0032012)3.32178457
71rhodopsin mediated signaling pathway (GO:0016056)3.30722273
72regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.27162535
73sarcoplasmic reticulum calcium ion transport (GO:0070296)3.26030349
74negative regulation of potassium ion transmembrane transport (GO:1901380)3.24400930
75muscle cell cellular homeostasis (GO:0046716)3.23231730
76striatum development (GO:0021756)3.21934576
77cell wall macromolecule metabolic process (GO:0044036)3.21687728
78cell wall macromolecule catabolic process (GO:0016998)3.21687728
79cellular sodium ion homeostasis (GO:0006883)3.17976775
80positive regulation of TOR signaling (GO:0032008)3.17520417
81regulation of secondary heart field cardioblast proliferation (GO:0003266)3.17394341
82regulation of cardioblast proliferation (GO:0003264)3.17394341
83regulation of transforming growth factor beta2 production (GO:0032909)3.16443725
84cardiac muscle cell action potential involved in contraction (GO:0086002)3.15302772
85peptide cross-linking (GO:0018149)3.13060290
86cardiac muscle cell action potential (GO:0086001)3.11599245
87ventricular cardiac muscle cell action potential (GO:0086005)3.11074646
88cardiac myofibril assembly (GO:0055003)3.07094115
89regulation of skeletal muscle cell differentiation (GO:2001014)3.06798312
90positive regulation of sodium ion transport (GO:0010765)3.06622677
91detection of visible light (GO:0009584)3.04464037
92neuronal action potential propagation (GO:0019227)3.03972237
93endothelial cell chemotaxis (GO:0035767)3.03679396
94regulation of the force of heart contraction (GO:0002026)3.03266186
95protein-chromophore linkage (GO:0018298)3.02261618
96cytoskeletal anchoring at plasma membrane (GO:0007016)3.00675959
97regulation of skeletal muscle contraction (GO:0014819)3.00348670
98detection of light stimulus (GO:0009583)3.00258081
99vocalization behavior (GO:0071625)2.99505518
100regulation of bile acid biosynthetic process (GO:0070857)2.97055528
101regulation of synaptic vesicle exocytosis (GO:2000300)2.97015300
102positive regulation of calcium ion import (GO:0090280)2.96507940
103relaxation of cardiac muscle (GO:0055119)2.95900679
104response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.95766381
105relaxation of muscle (GO:0090075)2.95157048
106positive regulation of vascular permeability (GO:0043117)2.94865834
107negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93922816
108positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.92299707
109cGMP-mediated signaling (GO:0019934)2.92282015
110regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.91529622
111muscle organ morphogenesis (GO:0048644)2.91336780
112neuromuscular process controlling balance (GO:0050885)2.89906539
113regulation of heart rate by cardiac conduction (GO:0086091)2.89678514
114import into cell (GO:0098657)2.89447242
115regulation of neuronal synaptic plasticity (GO:0048168)2.89357142
116cell communication involved in cardiac conduction (GO:0086065)2.89000104
117regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.87052057
118regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.85542535
119polyketide metabolic process (GO:0030638)2.84892811
120doxorubicin metabolic process (GO:0044598)2.84892811
121daunorubicin metabolic process (GO:0044597)2.84892811
122regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84642784
123negative regulation of thymocyte apoptotic process (GO:0070244)2.83813519
124regulation of rhodopsin mediated signaling pathway (GO:0022400)2.83143471
125muscle filament sliding (GO:0030049)2.82957840
126actin-myosin filament sliding (GO:0033275)2.82957840
127regulation of neurotransmitter secretion (GO:0046928)2.82936543
128retinoic acid receptor signaling pathway (GO:0048384)2.82509134
129cellular response to epinephrine stimulus (GO:0071872)2.82134742
130membrane depolarization during action potential (GO:0086010)2.81989935
131regulation of sarcomere organization (GO:0060297)2.81731123
132regulation of response to osmotic stress (GO:0047484)2.81371251
133central nervous system myelination (GO:0022010)2.81245171
134axon ensheathment in central nervous system (GO:0032291)2.81245171
135negative regulation of cell size (GO:0045792)2.80915712
136mating behavior (GO:0007617)2.79246359
137pyrimidine dimer repair (GO:0006290)2.78702201
138detection of temperature stimulus (GO:0016048)2.76305578
139negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.75507044
140myofibril assembly (GO:0030239)2.74980482
141membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.74595895
142skeletal muscle contraction (GO:0003009)2.74087392
143regulation of heart contraction (GO:0008016)2.73826921
144regulation of striated muscle contraction (GO:0006942)2.73766019
145long term synaptic depression (GO:0060292)2.73603713
146regulation of sodium ion transmembrane transport (GO:1902305)2.73599731
147regulation of sodium ion transport (GO:0002028)2.73513060
148regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.73021221
149striated muscle contraction (GO:0006941)2.72109158
150positive regulation of dendritic spine morphogenesis (GO:0061003)2.71761334
151iron ion import (GO:0097286)2.71001095
152regulation of cardiac muscle contraction (GO:0055117)2.70116033
153regulation of long-term neuronal synaptic plasticity (GO:0048169)2.70103237
154neurotransmitter-gated ion channel clustering (GO:0072578)2.69794288
155regulation of sodium ion transmembrane transporter activity (GO:2000649)2.69661331
156regulation of calcium ion transmembrane transport (GO:1903169)2.68955990
157regulation of calcium ion transmembrane transporter activity (GO:1901019)2.68955990
158negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.67761946
159positive regulation of CREB transcription factor activity (GO:0032793)2.65819608
160synaptic vesicle docking involved in exocytosis (GO:0016081)2.65675768
161regulation of membrane repolarization (GO:0060306)2.65355605
162pyruvate metabolic process (GO:0006090)2.64380234
163neurotransmitter transport (GO:0006836)2.63712283
164maintenance of protein location in nucleus (GO:0051457)2.63572195
165cerebellar Purkinje cell differentiation (GO:0021702)2.63401389
166negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.62925531
167negative regulation of calcium ion transmembrane transport (GO:1903170)2.62925531
168actomyosin structure organization (GO:0031032)2.62119410
169muscle contraction (GO:0006936)2.61611262
170membrane hyperpolarization (GO:0060081)2.61601099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.62686892
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.48900311
3EZH2_22144423_ChIP-Seq_EOC_Human3.36921292
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.24651231
5ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.84937971
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.51216705
7P53_22127205_ChIP-Seq_FIBROBLAST_Human2.49135870
8HIF1A_21447827_ChIP-Seq_MCF-7_Human2.49085978
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.48405416
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38258383
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24677454
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.13798895
13DROSHA_22980978_ChIP-Seq_HELA_Human2.08538139
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.04850348
15EZH2_27294783_Chip-Seq_ESCs_Mouse1.98480828
16GBX2_23144817_ChIP-Seq_PC3_Human1.96308257
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90014923
18CTCF_27219007_Chip-Seq_Bcells_Human1.86911965
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.85887588
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.83665294
21* REST_21632747_ChIP-Seq_MESCs_Mouse1.83241303
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82544706
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.79196831
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78344189
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78344189
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77746431
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77490404
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77450690
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73831220
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.71889004
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.70655914
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69557676
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68343720
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.67806257
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.66991114
36CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.61150844
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60289539
38ELK4_26923725_Chip-Seq_MESODERM_Mouse1.57016460
39AR_21572438_ChIP-Seq_LNCaP_Human1.54466698
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53063490
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51843069
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51263961
43* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49758520
44SMAD3_21741376_ChIP-Seq_HESCs_Human1.49306671
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.47535772
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47155247
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.47075573
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.47075573
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.47075573
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45074383
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43276152
52KDM2B_26808549_Chip-Seq_K562_Human1.41984555
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.37927928
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37286409
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37237867
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36837924
57* SMC4_20622854_ChIP-Seq_HELA_Human1.36494547
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35495443
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32613388
60* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30870465
61* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29925771
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28884442
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.27902525
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27758299
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.27385687
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26522226
67AHR_22903824_ChIP-Seq_MCF-7_Human1.26083357
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.24462710
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24219638
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.23796692
71* CREB1_26743006_Chip-Seq_LNCaP_Human1.23191400
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22972221
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.22956782
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22925221
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22395697
76AR_19668381_ChIP-Seq_PC3_Human1.21694754
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19622563
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17611671
79RACK7_27058665_Chip-Seq_MCF-7_Human1.17404800
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17265848
81* P68_20966046_ChIP-Seq_HELA_Human1.16234391
82SMAD4_21741376_ChIP-Seq_HESCs_Human1.15965429
83TET1_21490601_ChIP-Seq_MESCs_Mouse1.15357333
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15220565
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14912900
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14873610
87TP53_23651856_ChIP-Seq_MEFs_Mouse1.14738101
88YY1_22570637_ChIP-Seq_MALME-3M_Human1.13373259
89TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11600682
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11089340
91TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10649881
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09712812
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09615797
94* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08061187
95KDM2B_26808549_Chip-Seq_DND41_Human1.06719722
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06695918
97RUNX1_27514584_Chip-Seq_MCF-7_Human1.06129595
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05808248
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04708428
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03508412
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03205354
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.02795202
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02469325
104NANOG_20526341_ChIP-Seq_ESCs_Human1.02441077
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02002579
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01805944
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00857953
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98857573
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.97769756
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.97769756
111CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97642304
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97611510
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97360831
114EED_16625203_ChIP-ChIP_MESCs_Mouse0.97189395
115WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96103803
116CTCF_21964334_Chip-Seq_Bcells_Human0.96036082
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95396150
118* CTCF_20526341_ChIP-Seq_ESCs_Human0.95335266
119YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94876377
120ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94839012
121* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94396583
122* LXR_22292898_ChIP-Seq_THP-1_Human0.93773108
123KDM2B_26808549_Chip-Seq_JURKAT_Human0.93397843
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.91988541
125FOXA2_19822575_ChIP-Seq_HepG2_Human0.91927879
126SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91406273
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91189245
128OCT4_19829295_ChIP-Seq_ESCs_Human0.89628116
129TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89615706
130SOX3_22085726_ChIP-Seq_NPCs_Mouse0.89381011
131SOX2_21211035_ChIP-Seq_LN229_Gbm0.89013114
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88850595
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88603933
134KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87541688
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87537054
136RNF2_27304074_Chip-Seq_NSC_Mouse0.87314616
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85254583
138CBX2_27304074_Chip-Seq_ESCs_Mouse0.84623713
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82563091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog5.41719948
2MP0004859_abnormal_synaptic_plasticity4.00995924
3MP0002090_abnormal_vision3.97608168
4MP0005423_abnormal_somatic_nervous3.59961242
5MP0006292_abnormal_olfactory_placode3.49961813
6MP0006072_abnormal_retinal_apoptosis3.45178399
7MP0002234_abnormal_pharynx_morphology3.37556700
8MP0004084_abnormal_cardiac_muscle3.32033779
9MP0003011_delayed_dark_adaptation3.14248467
10MP0004510_myositis2.96841371
11MP0000751_myopathy2.91598489
12MP0004233_abnormal_muscle_weight2.82092253
13MP0004036_abnormal_muscle_relaxation2.81572545
14MP0005253_abnormal_eye_physiology2.70011910
15MP0003880_abnormal_central_pattern2.67587094
16MP0010030_abnormal_orbit_morphology2.65862093
17MP0003646_muscle_fatigue2.55849275
18MP0000749_muscle_degeneration2.55350587
19MP0001984_abnormal_olfaction2.32376691
20MP0003950_abnormal_plasma_membrane2.32075551
21MP0002332_abnormal_exercise_endurance2.29876572
22MP0001968_abnormal_touch/_nociception2.29011750
23MP0002735_abnormal_chemical_nociception2.27294913
24MP0005248_abnormal_Harderian_gland2.21898084
25MP0008775_abnormal_heart_ventricle2.19994531
26MP0004215_abnormal_myocardial_fiber2.19698927
27MP0003879_abnormal_hair_cell2.18639286
28MP0009745_abnormal_behavioral_response2.17866533
29MP0001501_abnormal_sleep_pattern2.15278210
30MP0005167_abnormal_blood-brain_barrier2.14148930
31MP0005394_taste/olfaction_phenotype2.12183377
32MP0005499_abnormal_olfactory_system2.12183377
33MP0005195_abnormal_posterior_eye2.10451450
34MP0002063_abnormal_learning/memory/cond2.08615671
35MP0002909_abnormal_adrenal_gland2.00608102
36MP0004484_altered_response_of1.90542693
37MP0001502_abnormal_circadian_rhythm1.89062091
38MP0010368_abnormal_lymphatic_system1.86449134
39MP0000750_abnormal_muscle_regeneration1.78321825
40MP0004145_abnormal_muscle_electrophysio1.77214668
41MP0004782_abnormal_surfactant_physiolog1.77024006
42MP0010386_abnormal_urinary_bladder1.73444913
43MP0008789_abnormal_olfactory_epithelium1.68054059
44MP0000759_abnormal_skeletal_muscle1.65608898
45MP0002736_abnormal_nociception_after1.65437174
46MP0002572_abnormal_emotion/affect_behav1.59194775
47MP0001346_abnormal_lacrimal_gland1.57090782
48MP0005646_abnormal_pituitary_gland1.56819784
49MP0003045_fibrosis1.56680753
50MP0005670_abnormal_white_adipose1.56480455
51MP0002269_muscular_atrophy1.55287936
52MP0004087_abnormal_muscle_fiber1.54831582
53MP0000537_abnormal_urethra_morphology1.54055628
54MP0005620_abnormal_muscle_contractility1.52585792
55MP0003890_abnormal_embryonic-extraembry1.49247527
56MP0000762_abnormal_tongue_morphology1.48149505
57MP0002837_dystrophic_cardiac_calcinosis1.44976885
58MP0006138_congestive_heart_failure1.41974774
59MP0001970_abnormal_pain_threshold1.41013265
60MP0003137_abnormal_impulse_conducting1.38374446
61MP0002106_abnormal_muscle_physiology1.36753203
62MP0008961_abnormal_basal_metabolism1.36007071
63MP0002127_abnormal_cardiovascular_syste1.34279594
64MP0001324_abnormal_eye_pigmentation1.32353660
65MP0005391_vision/eye_phenotype1.31901629
66MP0003633_abnormal_nervous_system1.29514945
67MP0000920_abnormal_myelination1.26427694
68MP0005385_cardiovascular_system_phenoty1.26349181
69MP0001544_abnormal_cardiovascular_syste1.26349181
70MP0005330_cardiomyopathy1.26185112
71MP0003705_abnormal_hypodermis_morpholog1.24629791
72MP0000747_muscle_weakness1.24551885
73MP0002108_abnormal_muscle_morphology1.22186367
74MP0002653_abnormal_ependyma_morphology1.22103679
75MP0002752_abnormal_somatic_nervous1.21112281
76MP0005369_muscle_phenotype1.20538812
77MP0003329_amyloid_beta_deposits1.19885018
78MP0002733_abnormal_thermal_nociception1.19077846
79MP0001664_abnormal_digestion1.17932307
80MP0001348_abnormal_lacrimal_gland1.16530520
81MP0002972_abnormal_cardiac_muscle1.11596121
82MP0000678_abnormal_parathyroid_gland1.10216059
83MP0002229_neurodegeneration1.10033114
84MP0003631_nervous_system_phenotype1.09155042
85MP0003690_abnormal_glial_cell1.08704257
86MP0008004_abnormal_stomach_pH1.04702639
87MP0009780_abnormal_chondrocyte_physiolo1.04110206
88MP0005623_abnormal_meninges_morphology1.04046313
89MP0005409_darkened_coat_color1.03409566
90MP0001756_abnormal_urination1.02906055
91MP0006035_abnormal_mitochondrial_morpho1.02657395
92MP0005386_behavior/neurological_phenoty1.01449593
93MP0004924_abnormal_behavior1.01449593
94MP0002066_abnormal_motor_capabilities/c1.01262198
95MP0009697_abnormal_copulation1.00177702
96MP0004185_abnormal_adipocyte_glucose0.99277539
97MP0004811_abnormal_neuron_physiology0.98751221
98MP0004085_abnormal_heartbeat0.98164338
99MP0003315_abnormal_perineum_morphology0.96713478
100MP0000733_abnormal_muscle_development0.96373336
101MP0005666_abnormal_adipose_tissue0.95838264
102MP0002184_abnormal_innervation0.95780344
103MP0002557_abnormal_social/conspecific_i0.95633320
104MP0003221_abnormal_cardiomyocyte_apopto0.95124938
105MP0001486_abnormal_startle_reflex0.92933336
106MP0000230_abnormal_systemic_arterial0.91864907
107MP0002734_abnormal_mechanical_nocicepti0.88343205
108MP0004858_abnormal_nervous_system0.87726741
109MP0001440_abnormal_grooming_behavior0.87351386
110MP0002822_catalepsy0.85497003
111MP0008874_decreased_physiological_sensi0.84407769
112MP0001765_abnormal_ion_homeostasis0.81711127
113MP0002067_abnormal_sensory_capabilities0.78541231
114MP0004264_abnormal_extraembryonic_tissu0.76913441
115MP0000538_abnormal_urinary_bladder0.76061837
116MP0009046_muscle_twitch0.74031405
117MP0002933_joint_inflammation0.73688363
118MP0002882_abnormal_neuron_morphology0.73432164
119MP0010630_abnormal_cardiac_muscle0.73031222
120MP0003634_abnormal_glial_cell0.72246449
121MP0001986_abnormal_taste_sensitivity0.72101189
122MP0003279_aneurysm0.70392018
123MP0003632_abnormal_nervous_system0.70326514
124MP0001270_distended_abdomen0.70225389
125MP0005375_adipose_tissue_phenotype0.69456371
126MP0005266_abnormal_metabolism0.69284353
127MP0008569_lethality_at_weaning0.68366706
128MP0003635_abnormal_synaptic_transmissio0.68072422
129MP0005275_abnormal_skin_tensile0.67797276
130MP0003935_abnormal_craniofacial_develop0.67606354
131MP0000428_abnormal_craniofacial_morphol0.67419239
132MP0002064_seizures0.66162440
133MP0000013_abnormal_adipose_tissue0.66127600
134MP0004130_abnormal_muscle_cell0.66013198
135MP0002272_abnormal_nervous_system0.64987388
136MP0000631_abnormal_neuroendocrine_gland0.64458720
137MP0005535_abnormal_body_temperature0.64172835
138MP0003828_pulmonary_edema0.63631018
139MP0000955_abnormal_spinal_cord0.63604742
140MP0002089_abnormal_postnatal_growth/wei0.62795356
141MP0001188_hyperpigmentation0.62203020
142MP0001177_atelectasis0.61891817
143MP0004270_analgesia0.60761548
144MP0002932_abnormal_joint_morphology0.60045793
145MP0005595_abnormal_vascular_smooth0.59919622
146MP0002277_abnormal_respiratory_mucosa0.59844208
147MP0002638_abnormal_pupillary_reflex0.59634353
148MP0002233_abnormal_nose_morphology0.59414109
149MP0003755_abnormal_palate_morphology0.58656276
150MP0003183_abnormal_peptide_metabolism0.58515686
151MP0004043_abnormal_pH_regulation0.58214344
152MP0000534_abnormal_ureter_morphology0.58078446
153MP0001293_anophthalmia0.56109808

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)6.69695744
2Bundle branch block (HP:0011710)6.33714644
3Myokymia (HP:0002411)6.05218499
4Severe visual impairment (HP:0001141)5.50221124
5Abnormality of macular pigmentation (HP:0008002)5.48022729
6Scotoma (HP:0000575)5.22691511
7Sudden death (HP:0001699)5.18712506
8Abnormal rod and cone electroretinograms (HP:0008323)4.70967501
9Heart block (HP:0012722)4.47258286
10Decreased central vision (HP:0007663)4.32129924
11Abnormal atrioventricular conduction (HP:0005150)4.26660643
12Pendular nystagmus (HP:0012043)4.02923779
13Aortic aneurysm (HP:0004942)3.92166477
14Exercise-induced myalgia (HP:0003738)3.91470351
15Atrioventricular block (HP:0001678)3.90725866
16Septo-optic dysplasia (HP:0100842)3.88088838
17Exercise-induced muscle cramps (HP:0003710)3.80575120
18Obstructive sleep apnea (HP:0002870)3.78466175
19Atonic seizures (HP:0010819)3.77653784
20Right ventricular cardiomyopathy (HP:0011663)3.70671820
21Bony spicule pigmentary retinopathy (HP:0007737)3.70590656
22Focal motor seizures (HP:0011153)3.59892644
23Papilledema (HP:0001085)3.59119806
24Postural instability (HP:0002172)3.54348244
25Dysmetric saccades (HP:0000641)3.42152700
26Focal seizures (HP:0007359)3.35094774
27Aplasia/Hypoplasia of the fovea (HP:0008060)3.33988249
28Hypoplasia of the fovea (HP:0007750)3.33988249
29Increased connective tissue (HP:0009025)3.27744453
30Resting tremor (HP:0002322)3.21829066
31Ankle clonus (HP:0011448)3.21496221
32Keratoconus (HP:0000563)3.19763078
33Increased corneal curvature (HP:0100692)3.19763078
34Oral leukoplakia (HP:0002745)3.18693233
35Ventricular arrhythmia (HP:0004308)3.17729003
36Ventricular tachycardia (HP:0004756)3.10700185
37Action tremor (HP:0002345)3.07573491
38Type 1 muscle fiber predominance (HP:0003803)3.06256129
39Epileptic encephalopathy (HP:0200134)3.05521636
40Progressive cerebellar ataxia (HP:0002073)3.01302352
41Increased variability in muscle fiber diameter (HP:0003557)2.97927787
42Hypoplastic ischia (HP:0003175)2.97485694
43Difficulty running (HP:0009046)2.94763645
44Febrile seizures (HP:0002373)2.92880036
45Neoplasm of the heart (HP:0100544)2.87741679
46Round ear (HP:0100830)2.85501506
47Distal lower limb muscle weakness (HP:0009053)2.83789525
48Annular pancreas (HP:0001734)2.80097593
49Supranuclear gaze palsy (HP:0000605)2.77143650
50Ulnar deviation of the wrist (HP:0003049)2.73641969
51EMG: myopathic abnormalities (HP:0003458)2.72375784
52Myoglobinuria (HP:0002913)2.72189122
53Truncal ataxia (HP:0002078)2.71810683
54Abnormality of binocular vision (HP:0011514)2.71363815
55Diplopia (HP:0000651)2.71363815
56Foot dorsiflexor weakness (HP:0009027)2.69842858
57Abnormal gallbladder physiology (HP:0012438)2.66380526
58Cholecystitis (HP:0001082)2.66380526
59Dilated cardiomyopathy (HP:0001644)2.66246496
60Lipoatrophy (HP:0100578)2.65511735
61Abnormality of skeletal muscle fiber size (HP:0012084)2.63409196
62Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.63256221
63Dyschromatopsia (HP:0007641)2.61941655
64Abnormality of the fovea (HP:0000493)2.60842207
65Cone-rod dystrophy (HP:0000548)2.60816415
66Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.57443193
67Muscle fiber inclusion bodies (HP:0100299)2.56120119
68Cerebral hypomyelination (HP:0006808)2.52885036
69Abnormality of the calf musculature (HP:0001430)2.52691273
70Abdominal situs inversus (HP:0003363)2.50887633
71Abnormality of abdominal situs (HP:0011620)2.50887633
72Abnormality of the foot musculature (HP:0001436)2.49907819
73Muscle fiber splitting (HP:0003555)2.49794500
74Abnormality of the ischium (HP:0003174)2.48627185
75Atrial fibrillation (HP:0005110)2.48491971
76Asymmetric septal hypertrophy (HP:0001670)2.48378130
77Vitreoretinal degeneration (HP:0000655)2.47076990
78EMG: neuropathic changes (HP:0003445)2.45669245
79Ependymoma (HP:0002888)2.43774713
80Prolonged QT interval (HP:0001657)2.43527850
81Dysmetria (HP:0001310)2.42759316
82Gaze-evoked nystagmus (HP:0000640)2.42105983
83Anxiety (HP:0000739)2.37373964
84Bradycardia (HP:0001662)2.32623357
85Clumsiness (HP:0002312)2.31032769
86Absent rod-and cone-mediated responses on ERG (HP:0007688)2.29133016
87Myopathic facies (HP:0002058)2.28667472
88Hepatoblastoma (HP:0002884)2.28638499
89Primary atrial arrhythmia (HP:0001692)2.26854835
90Calf muscle hypertrophy (HP:0008981)2.25851533
91Severe Myopia (HP:0011003)2.25474152
92Distal arthrogryposis (HP:0005684)2.25154804
93Bronchomalacia (HP:0002780)2.22453433
94Abnormality of the lower motor neuron (HP:0002366)2.21799953
95Neurofibrillary tangles (HP:0002185)2.19922338
96Mildly elevated creatine phosphokinase (HP:0008180)2.18923443
97Supraventricular tachycardia (HP:0004755)2.18457705
98Posterior subcapsular cataract (HP:0007787)2.17299394
99Spastic gait (HP:0002064)2.17289290
100Hyporeflexia of lower limbs (HP:0002600)2.16969179
101Muscle hypertrophy of the lower extremities (HP:0008968)2.15587318
102Aplasia/Hypoplasia of the macula (HP:0008059)2.15146211
103Hip contracture (HP:0003273)2.14987128
104Genetic anticipation (HP:0003743)2.14184472
105Cerebral aneurysm (HP:0004944)2.13804052
106Impaired smooth pursuit (HP:0007772)2.13638551
107Cupped ribs (HP:0000887)2.12386826
108Bulbar palsy (HP:0001283)2.12287389
109Depression (HP:0000716)2.11435875
110Fetal akinesia sequence (HP:0001989)2.10714213
111Supraventricular arrhythmia (HP:0005115)2.10435984
112Muscle stiffness (HP:0003552)2.10379496
113Nemaline bodies (HP:0003798)2.10170511
114Abnormality of the pubic bones (HP:0003172)2.09280129
115Hemiplegia (HP:0002301)2.09098425
116Waddling gait (HP:0002515)2.06612395
117Difficulty climbing stairs (HP:0003551)2.06550333
118Generalized tonic-clonic seizures (HP:0002069)2.05963129
119Poor eye contact (HP:0000817)2.05661669
120Frequent falls (HP:0002359)2.05650265
121Photophobia (HP:0000613)2.05582070
122Irregular epiphyses (HP:0010582)2.05339143
123Amelogenesis imperfecta (HP:0000705)2.05243099
124Aplasia/Hypoplasia affecting the retina (HP:0008061)2.05118459
125Areflexia of lower limbs (HP:0002522)2.05080491
126Ventricular fibrillation (HP:0001663)2.04005054
127Absence seizures (HP:0002121)2.03301829
128Tetraplegia (HP:0002445)2.00755014
129Scapular winging (HP:0003691)2.00250693
130Urinary urgency (HP:0000012)2.00162574
131Congenital stationary night blindness (HP:0007642)13.3738480
132Unsteady gait (HP:0002317)1.97857742
133Abolished electroretinogram (ERG) (HP:0000550)1.97280603
134Steppage gait (HP:0003376)1.96742475
135Abnormality of the astrocytes (HP:0100707)1.95212047
136Astrocytoma (HP:0009592)1.95212047
137Aplasia of the musculature (HP:0100854)1.94996742
138Sudden cardiac death (HP:0001645)1.92003725
139Chorioretinal atrophy (HP:0000533)1.91953522
140Rapidly progressive (HP:0003678)1.90577070
141Type II diabetes mellitus (HP:0005978)1.90525298
142Aneurysm (HP:0002617)1.90391796
143Albinism (HP:0001022)1.89975442
144Abnormality of ocular smooth pursuit (HP:0000617)1.89390622
145Stereotypic behavior (HP:0000733)1.89205146
146Urinary bladder sphincter dysfunction (HP:0002839)1.89179177
147Limited hip movement (HP:0008800)1.87519078
148Rimmed vacuoles (HP:0003805)1.87399295
149Abnormality of the shoulder girdle musculature (HP:0001435)1.86898655
150Lower limb muscle weakness (HP:0007340)1.86747214
151Pigmentary retinal degeneration (HP:0001146)1.86126227
152Partial duplication of thumb phalanx (HP:0009944)1.86023600
153Bradykinesia (HP:0002067)1.85845210
154Aortic dissection (HP:0002647)1.85386425
155Horizontal nystagmus (HP:0000666)1.83981958
156Mesomelia (HP:0003027)1.82930692
157Attenuation of retinal blood vessels (HP:0007843)1.82665576
158Visual hallucinations (HP:0002367)1.82347785
159Cerebral inclusion bodies (HP:0100314)1.82235092
160Absent septum pellucidum (HP:0001331)1.82025664
161Cholelithiasis (HP:0001081)1.81861501
162Lower limb amyotrophy (HP:0007210)1.81258024
163Slow progression (HP:0003677)1.80029653
164Bilateral microphthalmos (HP:0007633)1.76861600
165Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.73980062
166Constricted visual fields (HP:0001133)1.72827289
167Epiphyseal dysplasia (HP:0002656)1.72145741
168Dialeptic seizures (HP:0011146)1.71401319
169Limb-girdle muscle atrophy (HP:0003797)1.69405540
170Abnormal EKG (HP:0003115)1.69263496
171Hemiparesis (HP:0001269)1.69073580
172Distal lower limb amyotrophy (HP:0008944)1.66160737
173Syncope (HP:0001279)1.65669777
174Dysdiadochokinesis (HP:0002075)1.65103422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.57894860
2TTN3.99603312
3NEK13.92291819
4CDK123.48855747
5EPHA33.22270197
6PBK2.92310668
7TAOK22.84150625
8DAPK22.81853878
9PRPF4B2.65780362
10RIPK12.64701047
11STK38L2.61334602
12EEF2K2.54360777
13PHKG12.52241685
14PHKG22.52241685
15GRK52.28534111
16GRK12.12973086
17SGK4942.05887659
18SGK2232.05887659
19NTRK32.04270613
20MAP3K72.03389963
21ERN11.80539442
22STK381.76896946
23UHMK11.72878472
24TRIB31.69122654
25SGK21.68835852
26TNK21.67077810
27DYRK1A1.65548520
28PAK61.61190783
29CAMKK11.58733604
30NME11.57616706
31EPHA41.50714893
32GRK61.43278092
33MOS1.43124098
34PRKG21.40930888
35LATS21.39017677
36PINK11.31316944
37MAPKAPK31.31254482
38SGK31.29835631
39MAPK71.28863580
40ARAF1.28442218
41FER1.27782347
42MARK21.26843889
43PKN21.25463727
44DAPK31.23574151
45MAP3K41.22430796
46NTRK21.22208757
47OBSCN1.18923270
48DDR21.12132968
49PRKD31.11516061
50TGFBR21.10991407
51MAPK121.08657382
52MARK31.07460409
53PAK21.07351699
54PRKD21.06919570
55ADRBK21.03956845
56LMTK21.03380414
57HIPK20.98346023
58KSR20.97984485
59CSF1R0.97293052
60PIK3CG0.96557879
61CDK50.93300759
62SIK20.90627149
63INSRR0.90506373
64PRKAA10.90239420
65LATS10.90035406
66CAMK40.89955715
67FGFR30.87331407
68PAK30.87264421
69PDPK10.84070265
70MAP2K40.83009268
71TAOK10.80219662
72BMX0.77333053
73SIK10.76748559
74MAP3K100.75788436
75MINK10.75126243
76AKT20.75042353
77CAMK2G0.74591843
78DYRK1B0.74421470
79SGK10.73680870
80WNK10.69137771
81CDK140.68900125
82ICK0.68871078
83CAMK2B0.68456008
84PTK20.66687477
85MAP3K130.66612391
86EPHB10.66449088
87FES0.65804145
88CAMK2D0.65508250
89MAPK150.64655611
90MAPK130.64018345
91NEK60.61982048
92RPS6KA20.61790257
93TRPM70.61452068
94PKN10.61085062
95MAP3K10.59245461
96ADRBK10.59164975
97CAMK10.58910736
98FGFR40.56091381
99CDK150.56041346
100MARK10.56025632
101ROCK20.55397489
102PRKD10.55285775
103PRKAA20.53686101
104RET0.53278952
105DMPK0.53107846
106PRKCH0.52956505
107MAP3K50.51982222
108STK110.50131800
109MTOR0.49700449
110GRK70.49300918
111CAMKK20.48929890
112CDK11A0.48851920
113CDK180.48360383
114MAP3K60.48119131
115FGFR10.47860632
116TYRO30.47360638
117MUSK0.47011721
118ERBB20.45975953
119CDK80.45520238
120MAPK100.44183490
121IRAK20.42120505
122ROCK10.42095570
123RPS6KB10.42049005
124DAPK10.41039541
125PRKG10.40962013
126RPS6KA30.40011362
127BRAF0.39864461
128CAMK1D0.39657437
129NEK20.38037130
130MAP2K60.37806575
131MAP3K90.37647222
132AKT30.37403392
133MAP2K10.36938658
134NLK0.36904329
135STK390.36515118
136CDC42BPA0.36182903
137CAMK1G0.35514062
138FGFR20.35476884
139GSK3B0.34880338
140CAMK2A0.34300510
141PDK40.34275383
142PDK30.34275383
143MAPK80.34121824
144MAPK40.33130894
145PRKACA0.32083857
146PDK10.31328019
147PIK3CA0.30836275

Predicted pathways (KEGG)

RankGene SetZ-score
1GABAergic synapse_Homo sapiens_hsa047273.08862821
2Synaptic vesicle cycle_Homo sapiens_hsa047213.00564293
3Phototransduction_Homo sapiens_hsa047442.93733467
4Nicotine addiction_Homo sapiens_hsa050332.85575535
5Dilated cardiomyopathy_Homo sapiens_hsa054142.58564373
6Morphine addiction_Homo sapiens_hsa050322.52875577
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.52866658
8Fructose and mannose metabolism_Homo sapiens_hsa000512.51286633
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.50693379
10Salivary secretion_Homo sapiens_hsa049702.48436912
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32445063
12Olfactory transduction_Homo sapiens_hsa047402.26620452
13Long-term potentiation_Homo sapiens_hsa047202.24555156
14Cardiac muscle contraction_Homo sapiens_hsa042602.22359275
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.20412497
16Circadian rhythm_Homo sapiens_hsa047102.06005340
17Amphetamine addiction_Homo sapiens_hsa050312.04391126
18Circadian entrainment_Homo sapiens_hsa047131.99291166
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98941432
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.86958230
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.84354186
22Renin secretion_Homo sapiens_hsa049241.74091840
23Insulin secretion_Homo sapiens_hsa049111.72620988
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.71811440
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68306201
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.58613132
27Oxytocin signaling pathway_Homo sapiens_hsa049211.58084829
28Cocaine addiction_Homo sapiens_hsa050301.53732973
29Galactose metabolism_Homo sapiens_hsa000521.46815264
30mTOR signaling pathway_Homo sapiens_hsa041501.43546588
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.40741311
32Biosynthesis of amino acids_Homo sapiens_hsa012301.39431368
33Calcium signaling pathway_Homo sapiens_hsa040201.38180744
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37567508
35Cholinergic synapse_Homo sapiens_hsa047251.36371919
36Glutamatergic synapse_Homo sapiens_hsa047241.34517399
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.33906526
38Pancreatic secretion_Homo sapiens_hsa049721.27373199
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26518822
40Serotonergic synapse_Homo sapiens_hsa047261.26447134
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26376645
42Estrogen signaling pathway_Homo sapiens_hsa049151.24894733
43Bile secretion_Homo sapiens_hsa049761.23876339
44Arginine biosynthesis_Homo sapiens_hsa002201.23506495
45Taste transduction_Homo sapiens_hsa047421.21675925
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16443396
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14689367
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09233458
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07611278
50Inositol phosphate metabolism_Homo sapiens_hsa005621.05000374
51HIF-1 signaling pathway_Homo sapiens_hsa040661.03537543
52ECM-receptor interaction_Homo sapiens_hsa045121.02589376
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02056132
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99606565
55Arginine and proline metabolism_Homo sapiens_hsa003300.97446908
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96216641
57Dopaminergic synapse_Homo sapiens_hsa047280.95294108
58Thyroid hormone synthesis_Homo sapiens_hsa049180.93990690
59Carbon metabolism_Homo sapiens_hsa012000.92539922
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90245742
61beta-Alanine metabolism_Homo sapiens_hsa004100.89667796
62Melanogenesis_Homo sapiens_hsa049160.88976016
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85256541
64Histidine metabolism_Homo sapiens_hsa003400.82664061
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81903084
66Fatty acid biosynthesis_Homo sapiens_hsa000610.80758386
67Glucagon signaling pathway_Homo sapiens_hsa049220.78767403
68GnRH signaling pathway_Homo sapiens_hsa049120.78719747
69ABC transporters_Homo sapiens_hsa020100.76584533
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.76175814
71Pentose phosphate pathway_Homo sapiens_hsa000300.73545010
72Protein digestion and absorption_Homo sapiens_hsa049740.71400512
73Type II diabetes mellitus_Homo sapiens_hsa049300.68933255
74MAPK signaling pathway_Homo sapiens_hsa040100.68399544
75Prostate cancer_Homo sapiens_hsa052150.67111358
76AMPK signaling pathway_Homo sapiens_hsa041520.66992970
77Collecting duct acid secretion_Homo sapiens_hsa049660.65906256
78cAMP signaling pathway_Homo sapiens_hsa040240.65641751
79Choline metabolism in cancer_Homo sapiens_hsa052310.64870469
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58910918
81PPAR signaling pathway_Homo sapiens_hsa033200.57925865
82Gap junction_Homo sapiens_hsa045400.57415493
83Tight junction_Homo sapiens_hsa045300.56693771
84Glycerolipid metabolism_Homo sapiens_hsa005610.55655298
85Long-term depression_Homo sapiens_hsa047300.55377305
86Ovarian steroidogenesis_Homo sapiens_hsa049130.54242270
87Oocyte meiosis_Homo sapiens_hsa041140.53213423
88VEGF signaling pathway_Homo sapiens_hsa043700.52961731
89ErbB signaling pathway_Homo sapiens_hsa040120.51982696
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51859907
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51561426
92Linoleic acid metabolism_Homo sapiens_hsa005910.49713302
93Insulin signaling pathway_Homo sapiens_hsa049100.49057767
94Focal adhesion_Homo sapiens_hsa045100.48985372
95Mineral absorption_Homo sapiens_hsa049780.47550630
96Renal cell carcinoma_Homo sapiens_hsa052110.46413646
97Colorectal cancer_Homo sapiens_hsa052100.46298694
98Insulin resistance_Homo sapiens_hsa049310.46294750
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45995878
100Phenylalanine metabolism_Homo sapiens_hsa003600.42898954
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.41671019
102FoxO signaling pathway_Homo sapiens_hsa040680.40356425
103Alcoholism_Homo sapiens_hsa050340.40258887
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40097872
105Platelet activation_Homo sapiens_hsa046110.39545682
106Arachidonic acid metabolism_Homo sapiens_hsa005900.39511346
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.39323776
108Gastric acid secretion_Homo sapiens_hsa049710.37813962
109Fatty acid metabolism_Homo sapiens_hsa012120.36000746
110Ras signaling pathway_Homo sapiens_hsa040140.35245051
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34396582
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.30781982
113Prion diseases_Homo sapiens_hsa050200.30264368
114Pancreatic cancer_Homo sapiens_hsa052120.28923385
115Rap1 signaling pathway_Homo sapiens_hsa040150.28767187
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27947638
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27598338
118B cell receptor signaling pathway_Homo sapiens_hsa046620.27500445
119Acute myeloid leukemia_Homo sapiens_hsa052210.27055606
120Starch and sucrose metabolism_Homo sapiens_hsa005000.26129832
121Endocytosis_Homo sapiens_hsa041440.25918992
122Glioma_Homo sapiens_hsa052140.25431614
123Vibrio cholerae infection_Homo sapiens_hsa051100.25075265
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24933963
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24503817
126Endometrial cancer_Homo sapiens_hsa052130.24132719
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23963770
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23101054
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22939775
130Proteoglycans in cancer_Homo sapiens_hsa052050.22048176
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21568998
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.21089937
133Lysine degradation_Homo sapiens_hsa003100.19895164

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