LMAN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.88809759
2COPI coating of Golgi vesicle (GO:0048205)4.88809759
3protein maturation by protein folding (GO:0022417)4.78869946
4L-phenylalanine metabolic process (GO:0006558)4.67190788
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.67190788
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.62067318
7L-phenylalanine catabolic process (GO:0006559)4.62067318
8alpha-linolenic acid metabolic process (GO:0036109)4.33797026
9sulfur amino acid catabolic process (GO:0000098)4.29195400
10valine metabolic process (GO:0006573)4.19359734
11cysteine metabolic process (GO:0006534)4.16303102
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.04956768
13aromatic amino acid family catabolic process (GO:0009074)4.04421767
14lysine metabolic process (GO:0006553)3.98363647
15lysine catabolic process (GO:0006554)3.98363647
16protein carboxylation (GO:0018214)3.96078635
17peptidyl-glutamic acid carboxylation (GO:0017187)3.96078635
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.85403591
19negative regulation of fibrinolysis (GO:0051918)3.79775992
20glyoxylate metabolic process (GO:0046487)3.78468369
21glycine metabolic process (GO:0006544)3.73933710
22kynurenine metabolic process (GO:0070189)3.73032247
23complement activation, alternative pathway (GO:0006957)3.72619074
24urea metabolic process (GO:0019627)3.72179797
25urea cycle (GO:0000050)3.72179797
26negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.71467938
274-hydroxyproline metabolic process (GO:0019471)3.59087408
28GDP-mannose metabolic process (GO:0019673)3.58978937
29proline biosynthetic process (GO:0006561)3.58878122
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.58666416
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57209392
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57209392
33regulation of protein activation cascade (GO:2000257)3.54808634
34indole-containing compound catabolic process (GO:0042436)3.53589081
35indolalkylamine catabolic process (GO:0046218)3.53589081
36tryptophan catabolic process (GO:0006569)3.53589081
37homocysteine metabolic process (GO:0050667)3.53487999
38regulation of triglyceride catabolic process (GO:0010896)3.49539778
39serine family amino acid catabolic process (GO:0009071)3.46146307
40amino-acid betaine metabolic process (GO:0006577)3.44561908
41high-density lipoprotein particle remodeling (GO:0034375)3.43937009
42tryptophan metabolic process (GO:0006568)3.42725372
43nitrogen cycle metabolic process (GO:0071941)3.42261328
44regulation of cholesterol homeostasis (GO:2000188)3.40772318
45bile acid biosynthetic process (GO:0006699)3.40748701
46pinocytosis (GO:0006907)3.40083352
47COPII vesicle coating (GO:0048208)3.39973052
48regulation of complement activation (GO:0030449)3.39609998
49serine family amino acid biosynthetic process (GO:0009070)3.35208719
50serine family amino acid metabolic process (GO:0009069)3.32181755
51tricarboxylic acid metabolic process (GO:0072350)3.32035530
52regulation of fibrinolysis (GO:0051917)3.26868035
53plasma lipoprotein particle clearance (GO:0034381)3.26487503
54low-density lipoprotein particle clearance (GO:0034383)3.25849197
55protein retention in ER lumen (GO:0006621)3.24259206
562-oxoglutarate metabolic process (GO:0006103)3.21672919
57activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.20318424
58folic acid-containing compound biosynthetic process (GO:0009396)3.16193618
59reverse cholesterol transport (GO:0043691)3.16162798
60negative regulation of sterol transport (GO:0032372)3.15612304
61negative regulation of cholesterol transport (GO:0032375)3.15612304
62positive regulation of nuclease activity (GO:0032075)3.15046426
63pentose-phosphate shunt (GO:0006098)3.12046871
64positive regulation of fatty acid beta-oxidation (GO:0032000)3.09216273
65protein-lipid complex remodeling (GO:0034368)3.08207802
66macromolecular complex remodeling (GO:0034367)3.08207802
67plasma lipoprotein particle remodeling (GO:0034369)3.08207802
68regulation of fatty acid beta-oxidation (GO:0031998)3.08150061
69aromatic amino acid family metabolic process (GO:0009072)3.08139053
70bile acid metabolic process (GO:0008206)3.07896598
71glucose catabolic process (GO:0006007)3.07679961
72triglyceride homeostasis (GO:0070328)3.06896836
73acylglycerol homeostasis (GO:0055090)3.06896836
74fatty acid beta-oxidation (GO:0006635)3.04685221
75intestinal cholesterol absorption (GO:0030299)3.04346361
76cellular modified amino acid catabolic process (GO:0042219)3.03309957
77positive regulation of triglyceride metabolic process (GO:0090208)3.00071221
78regulation of superoxide anion generation (GO:0032928)2.99935131
79antigen processing and presentation of endogenous antigen (GO:0019883)2.98160802
80ethanol oxidation (GO:0006069)2.96734481
81proline metabolic process (GO:0006560)2.96718539
82tyrosine metabolic process (GO:0006570)2.96261684
83phospholipid efflux (GO:0033700)2.95957793
84alpha-amino acid catabolic process (GO:1901606)2.95650845
85fatty acid oxidation (GO:0019395)2.95040201
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.94791629
87folic acid metabolic process (GO:0046655)2.93930135
88regulation of nuclease activity (GO:0032069)2.87944580
89lipid oxidation (GO:0034440)2.87148826
90endoplasmic reticulum unfolded protein response (GO:0030968)2.85566028
91negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.84350805
92NADPH regeneration (GO:0006740)2.84195853
93cellular amino acid catabolic process (GO:0009063)2.83729949
94lipoprotein metabolic process (GO:0042157)2.81890967
95bile acid and bile salt transport (GO:0015721)2.81522664
96pentose metabolic process (GO:0019321)2.80090987
97plasma lipoprotein particle assembly (GO:0034377)2.79660616
98positive regulation of triglyceride biosynthetic process (GO:0010867)2.78595716
99phospholipid homeostasis (GO:0055091)2.78326787
100oxaloacetate metabolic process (GO:0006107)2.78156668
101one-carbon metabolic process (GO:0006730)2.77025092
102positive regulation of lipid catabolic process (GO:0050996)2.76792739
103barbed-end actin filament capping (GO:0051016)2.75407321
104cellular response to unfolded protein (GO:0034620)2.74663280
105drug transmembrane transport (GO:0006855)2.74146700
106fatty acid catabolic process (GO:0009062)2.74133470
107tetrahydrofolate metabolic process (GO:0046653)2.73581505
108branched-chain amino acid metabolic process (GO:0009081)2.72674731
109antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.71893833
110regulation of cholesterol esterification (GO:0010872)2.71639633
111carnitine metabolic process (GO:0009437)2.71088205
112cholesterol homeostasis (GO:0042632)2.69878410
113urate metabolic process (GO:0046415)2.68702044
114amyloid precursor protein catabolic process (GO:0042987)2.64899411
115positive regulation of Cdc42 GTPase activity (GO:0043089)2.63579297
116antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.62535749
117* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.62418546
118UV protection (GO:0009650)2.60349758
119NADH metabolic process (GO:0006734)2.56195758
120ribosomal small subunit biogenesis (GO:0042274)2.55297812
121negative regulation of myeloid cell apoptotic process (GO:0033033)2.48503159
122glycosphingolipid catabolic process (GO:0046479)2.48412177
123mitotic nuclear envelope reassembly (GO:0007084)2.46820958
124nuclear envelope reassembly (GO:0031468)2.46820958
125hyaluronan catabolic process (GO:0030214)2.45189649
126NIK/NF-kappaB signaling (GO:0038061)2.42018269
127formation of translation preinitiation complex (GO:0001731)2.40709094
128nucleobase-containing small molecule interconversion (GO:0015949)2.39572129
129establishment of viral latency (GO:0019043)2.39229151
130glucose 6-phosphate metabolic process (GO:0051156)2.39047545
131pyrimidine-containing compound salvage (GO:0008655)2.34291327
132pyrimidine nucleoside salvage (GO:0043097)2.34291327
133regulation of mammary gland epithelial cell proliferation (GO:0033599)2.32993907
134glycolipid catabolic process (GO:0019377)2.32895207
135positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.31778431
136endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.31656439
137positive regulation of lipoprotein lipase activity (GO:0051006)2.28840384
138positive regulation of triglyceride lipase activity (GO:0061365)2.28840384
139glutamine family amino acid biosynthetic process (GO:0009084)2.25329712
140basement membrane organization (GO:0071711)2.21626793
141Arp2/3 complex-mediated actin nucleation (GO:0034314)2.19986471
142protein localization to endosome (GO:0036010)2.18897676
143antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.18574796
144peptidyl-arginine omega-N-methylation (GO:0035247)2.16985794
145fibrinolysis (GO:0042730)2.16753820
146virion assembly (GO:0019068)2.15365213
147regulation of cellular amino acid metabolic process (GO:0006521)2.14621467
148negative regulation of cell size (GO:0045792)2.14105280
149spliceosomal tri-snRNP complex assembly (GO:0000244)2.13108492
150chaperone mediated protein folding requiring cofactor (GO:0051085)2.13050411
151regulation of metalloenzyme activity (GO:0048552)2.11075181
152negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.10554865
153response to interferon-beta (GO:0035456)2.09627972
154glycoside metabolic process (GO:0016137)2.09436163
155purine ribonucleotide transport (GO:0015868)2.07721675
156T cell apoptotic process (GO:0070231)2.07066475
157modulation by symbiont of host cellular process (GO:0044068)2.06754835
158negative regulation of ligase activity (GO:0051352)2.06498171
159negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.06498171
160polyketide metabolic process (GO:0030638)2.05583527
161doxorubicin metabolic process (GO:0044598)2.05583527
162daunorubicin metabolic process (GO:0044597)2.05583527
163heme metabolic process (GO:0042168)2.05421884
164positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.05198365
165galactose catabolic process (GO:0019388)2.05175485
166purine deoxyribonucleotide catabolic process (GO:0009155)2.03688687
167regulation of mitochondrial membrane potential (GO:0051881)2.03547722
168peptidyl-proline hydroxylation (GO:0019511)2.02695413
169monosaccharide biosynthetic process (GO:0046364)2.02609040
170nucleotide salvage (GO:0043173)2.02338375
171immunoglobulin mediated immune response (GO:0016064)2.02071051
172maternal placenta development (GO:0001893)2.01878987
173regulation of mitochondrial translation (GO:0070129)2.01520206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.17375775
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.31005428
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.14159136
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.07536539
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.21677326
6* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.78573919
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.76193302
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.63595950
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62170928
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26411027
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.26383875
12E2F7_22180533_ChIP-Seq_HELA_Human2.21034657
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.20950248
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16687121
15CLOCK_20551151_ChIP-Seq_293T_Human2.12106677
16GATA1_22025678_ChIP-Seq_K562_Human2.08157815
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96380969
18IRF8_22096565_ChIP-ChIP_GC-B_Human1.87163210
19MYC_22102868_ChIP-Seq_BL_Human1.86649265
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84539510
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.79352684
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.78417047
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.77976286
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77405660
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71794554
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70053254
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69255360
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60772670
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59785956
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52543585
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.52495170
32VDR_21846776_ChIP-Seq_THP-1_Human1.51586258
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51543484
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49799514
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.42549158
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42282489
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41838671
38ZNF263_19887448_ChIP-Seq_K562_Human1.39846229
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36261880
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35034312
41* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33238725
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32483865
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29104120
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29030465
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28047097
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27785372
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25903909
48* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25737881
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23921175
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23670811
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.22852049
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22075681
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.21283484
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20788417
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20631019
56AR_21909140_ChIP-Seq_LNCAP_Human1.19785793
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18864006
58LXR_22292898_ChIP-Seq_THP-1_Human1.17655708
59P68_20966046_ChIP-Seq_HELA_Human1.17585228
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17396161
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16957912
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.16752058
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14292444
64ATF3_27146783_Chip-Seq_COLON_Human1.13434578
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12275683
66* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12206404
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12134684
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11872057
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11744931
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10960645
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09978208
72* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08505317
73* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08504862
74MAF_26560356_Chip-Seq_TH1_Human1.07986541
75BCOR_27268052_Chip-Seq_Bcells_Human1.07955681
76BCL6_27268052_Chip-Seq_Bcells_Human1.07562895
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07507189
78TFEB_21752829_ChIP-Seq_HELA_Human1.06699688
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06674405
80UTX_26944678_Chip-Seq_JUKART_Human1.06291479
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06228188
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.06228047
83RACK7_27058665_Chip-Seq_MCF-7_Human1.05106441
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.04704278
85CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03218948
86* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02743117
87MAF_26560356_Chip-Seq_TH2_Human1.02331304
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01588927
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01299397
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01275737
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01178617
92TCF7_22412390_ChIP-Seq_EML_Mouse1.00534598
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00170067
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99980650
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99733695
96NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99457096
97* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98359065
98* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98267185
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97394507
100* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97302278
101GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96691741
102DCP1A_22483619_ChIP-Seq_HELA_Human0.95119735
103GATA6_25053715_ChIP-Seq_YYC3_Human0.95029942
104ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94235050
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94195317
106* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93884580
107XRN2_22483619_ChIP-Seq_HELA_Human0.93881771
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93470547
109MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92921046
110* ETS1_20019798_ChIP-Seq_JURKAT_Human0.92718145
111VDR_24763502_ChIP-Seq_THP-1_Human0.92594655
112* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92570265
113KDM5A_27292631_Chip-Seq_BREAST_Human0.92541211
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92255036
115GATA4_25053715_ChIP-Seq_YYC3_Human0.91188330
116* GABP_19822575_ChIP-Seq_HepG2_Human0.91137194
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90821923
118MYB_26560356_Chip-Seq_TH1_Human0.90513535
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89196619
120NCOR1_26117541_ChIP-Seq_K562_Human0.88597436
121* GABP_17652178_ChIP-ChIP_JURKAT_Human0.88088216
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87709792
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87661568
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87047653
125SPI1_23547873_ChIP-Seq_NB4_Human0.86610164
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86393814
127IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85791710
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85706663
129FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85534384
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85382090
131* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84750751
132RUNX1_22412390_ChIP-Seq_EML_Mouse0.84515555
133KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83758248
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83456740

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.97652939
2MP0005360_urolithiasis4.55604811
3MP0005365_abnormal_bile_salt3.91091747
4MP0005085_abnormal_gallbladder_physiolo3.48891417
5MP0009840_abnormal_foam_cell3.17531628
6MP0003806_abnormal_nucleotide_metabolis2.82650695
7MP0003252_abnormal_bile_duct2.60993190
8MP0005451_abnormal_body_composition2.60807506
9MP0008875_abnormal_xenobiotic_pharmacok2.58118517
10MP0003705_abnormal_hypodermis_morpholog2.49567823
11MP0010329_abnormal_lipoprotein_level2.45001406
12MP0008260_abnormal_autophagy2.33082644
13MP0001666_abnormal_nutrient_absorption2.14984236
14MP0003191_abnormal_cellular_cholesterol2.13920899
15MP0003195_calcinosis2.11044386
16MP0005083_abnormal_biliary_tract2.06307038
17MP0003300_gastrointestinal_ulcer2.04520756
18MP0005332_abnormal_amino_acid1.91640226
19MP0000609_abnormal_liver_physiology1.87977967
20MP0004858_abnormal_nervous_system1.73627379
21MP0005058_abnormal_lysosome_morphology1.67445044
22MP0009643_abnormal_urine_homeostasis1.66463730
23MP0005319_abnormal_enzyme/_coenzyme1.54630364
24MP0006054_spinal_hemorrhage1.54000613
25MP0002118_abnormal_lipid_homeostasis1.50724729
26MP0004272_abnormal_basement_membrane1.49991430
27MP0005670_abnormal_white_adipose1.49459127
28MP0008438_abnormal_cutaneous_collagen1.49226686
29MP0002148_abnormal_hypersensitivity_rea1.49041448
30MP0002138_abnormal_hepatobiliary_system1.47546360
31MP0002877_abnormal_melanocyte_morpholog1.44698877
32MP0005220_abnormal_exocrine_pancreas1.44488671
33MP0010352_gastrointestinal_tract_polyps1.42775643
34MP0006082_CNS_inflammation1.42280333
35MP0005257_abnormal_intraocular_pressure1.40849567
36MP0004019_abnormal_vitamin_homeostasis1.40405942
37MP0009785_altered_susceptibility_to1.38227899
38MP0005501_abnormal_skin_physiology1.35753670
39MP0002796_impaired_skin_barrier1.34862553
40MP0003075_altered_response_to1.32357240
41MP0003186_abnormal_redox_activity1.31850126
42MP0010234_abnormal_vibrissa_follicle1.25819142
43MP0000598_abnormal_liver_morphology1.25771959
44MP0002132_abnormal_respiratory_system1.25480983
45MP0003436_decreased_susceptibility_to1.25282527
46MP0004264_abnormal_extraembryonic_tissu1.25118975
47MP0003453_abnormal_keratinocyte_physiol1.21854587
48MP0001849_ear_inflammation1.20839645
49MP0000343_altered_response_to1.20025310
50MP0005000_abnormal_immune_tolerance1.16208998
51MP0003566_abnormal_cell_adhesion1.15897495
52MP0009278_abnormal_bone_marrow1.15019233
53MP0004233_abnormal_muscle_weight1.14965141
54MP0005165_increased_susceptibility_to1.10705135
55MP0001756_abnormal_urination1.10530325
56MP0003868_abnormal_feces_composition1.10448629
57MP0000604_amyloidosis1.09915751
58MP0005666_abnormal_adipose_tissue1.08486116
59MP0001764_abnormal_homeostasis1.07667188
60MP0005584_abnormal_enzyme/coenzyme_acti1.05600775
61MP0001944_abnormal_pancreas_morphology1.04594389
62MP0008469_abnormal_protein_level1.03376747
63MP0000678_abnormal_parathyroid_gland1.02980671
64MP0003693_abnormal_embryo_hatching1.02810342
65MP0004185_abnormal_adipocyte_glucose1.00665097
66MP0003763_abnormal_thymus_physiology0.99903543
67MP0005023_abnormal_wound_healing0.99454329
68MP0002452_abnormal_antigen_presenting0.98869531
69MP0003656_abnormal_erythrocyte_physiolo0.98739742
70MP0003111_abnormal_nucleus_morphology0.98382962
71MP0002723_abnormal_immune_serum0.96298547
72MP0002078_abnormal_glucose_homeostasis0.96158978
73MP0001790_abnormal_immune_system0.95691943
74MP0005387_immune_system_phenotype0.95691943
75MP0005636_abnormal_mineral_homeostasis0.95667612
76MP0002420_abnormal_adaptive_immunity0.94491282
77MP0001819_abnormal_immune_cell0.94152532
78MP0000681_abnormal_thyroid_gland0.93916721
79MP0002166_altered_tumor_susceptibility0.93820930
80MP0002693_abnormal_pancreas_physiology0.92997366
81MP0000013_abnormal_adipose_tissue0.92159270
82MP0004782_abnormal_surfactant_physiolog0.91135784
83MP0001730_embryonic_growth_arrest0.91058645
84MP0000685_abnormal_immune_system0.90110072
85MP0005464_abnormal_platelet_physiology0.89309035
86MP0004947_skin_inflammation0.88918955
87MP0009763_increased_sensitivity_to0.88182020
88MP0003448_altered_tumor_morphology0.86231947
89MP0002136_abnormal_kidney_physiology0.85059596
90MP0002429_abnormal_blood_cell0.84983447
91MP0002998_abnormal_bone_remodeling0.84758250
92MP0001216_abnormal_epidermal_layer0.84638310
93MP0003303_peritoneal_inflammation0.84287464
94MP0002405_respiratory_system_inflammati0.84213431
95MP0005375_adipose_tissue_phenotype0.83931616
96MP0001881_abnormal_mammary_gland0.83746687
97MP0003724_increased_susceptibility_to0.83234542
98MP0001845_abnormal_inflammatory_respons0.83196808
99MP0003329_amyloid_beta_deposits0.83165265
100MP0005076_abnormal_cell_differentiation0.82595008
101MP0004130_abnormal_muscle_cell0.82449189
102MP0001542_abnormal_bone_strength0.81973225
103MP0002722_abnormal_immune_system0.81641735
104MP0005671_abnormal_response_to0.80908851
105MP0000465_gastrointestinal_hemorrhage0.80875438
106MP0005275_abnormal_skin_tensile0.80732914
107MP0002060_abnormal_skin_morphology0.80408571
108MP0003172_abnormal_lysosome_physiology0.79857737
109MP0004510_myositis0.79540949
110MP0000358_abnormal_cell_content/0.79465003
111MP0009642_abnormal_blood_homeostasis0.78979714
112MP0008932_abnormal_embryonic_tissue0.77592556
113MP0000716_abnormal_immune_system0.76778627
114MP0010155_abnormal_intestine_physiology0.76416315
115MP0001800_abnormal_humoral_immune0.76280349
116MP0008007_abnormal_cellular_replicative0.76018094
117MP0010368_abnormal_lymphatic_system0.75654738
118MP0000858_altered_metastatic_potential0.74633891
119MP0001533_abnormal_skeleton_physiology0.74436914
120MP0001835_abnormal_antigen_presentation0.73100652
121MP0002970_abnormal_white_adipose0.72257248
122MP0005334_abnormal_fat_pad0.71386468
123MP0002971_abnormal_brown_adipose0.70781396
124MP0002396_abnormal_hematopoietic_system0.70637414
125MP0005408_hypopigmentation0.70286101
126MP0006036_abnormal_mitochondrial_physio0.69795705
127MP0001661_extended_life_span0.69568768
128MP0002254_reproductive_system_inflammat0.68565587
129MP0000003_abnormal_adipose_tissue0.68297452
130MP0001853_heart_inflammation0.67910119
131MP0009672_abnormal_birth_weight0.65272205
132MP0001243_abnormal_dermal_layer0.65266366
133MP0005025_abnormal_response_to0.63631399
134MP0002419_abnormal_innate_immunity0.63266309
135MP0009764_decreased_sensitivity_to0.62625138
136MP0009333_abnormal_splenocyte_physiolog0.61698824
137MP0001873_stomach_inflammation0.61407379
138MP0002135_abnormal_kidney_morphology0.61158674
139MP0009384_cardiac_valve_regurgitation0.60775865
140MP0010307_abnormal_tumor_latency0.60441721
141MP0004957_abnormal_blastocyst_morpholog0.60432224
142MP0002909_abnormal_adrenal_gland0.60284485
143MP0003283_abnormal_digestive_organ0.59750170
144MP0004043_abnormal_pH_regulation0.57035214
145MP0009115_abnormal_fat_cell0.56553299
146MP0000477_abnormal_intestine_morphology0.56476057
147MP0000490_abnormal_crypts_of0.55891651
148MP0001545_abnormal_hematopoietic_system0.55848977
149MP0005397_hematopoietic_system_phenotyp0.55848977

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.88984843
2Deep venous thrombosis (HP:0002625)4.60822672
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.58659545
4Xanthomatosis (HP:0000991)4.45135034
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.36961588
6Intrahepatic cholestasis (HP:0001406)4.29290003
7Vertebral compression fractures (HP:0002953)4.04672659
8Abnormality of the common coagulation pathway (HP:0010990)3.68538346
9Abnormality of glycolipid metabolism (HP:0010969)3.68072058
10Abnormality of liposaccharide metabolism (HP:0010968)3.68072058
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.68072058
12Hypobetalipoproteinemia (HP:0003563)3.64332969
13Abnormality of the intrinsic pathway (HP:0010989)3.60937576
14Complement deficiency (HP:0004431)3.56076467
15Premature rupture of membranes (HP:0001788)3.48614821
16Ketosis (HP:0001946)3.47642230
17Prolonged partial thromboplastin time (HP:0003645)3.35082478
18Hyperammonemia (HP:0001987)3.31356855
19Hypoglycemic seizures (HP:0002173)3.29292001
20Hyperlipoproteinemia (HP:0010980)3.24760063
21Hyperglycinuria (HP:0003108)3.24726697
22Ketoacidosis (HP:0001993)3.21029121
23Cholecystitis (HP:0001082)3.20839037
24Abnormal gallbladder physiology (HP:0012438)3.20839037
25Hyperinsulinemic hypoglycemia (HP:0000825)3.14662972
26Hypolipoproteinemia (HP:0010981)3.05970553
27Abnormality of fatty-acid metabolism (HP:0004359)3.04773663
28Abnormality of glutamine family amino acid metabolism (HP:0010902)2.94206230
29Late onset (HP:0003584)2.91383152
30Abnormality of serine family amino acid metabolism (HP:0010894)2.90920188
31Abnormality of glycine metabolism (HP:0010895)2.90920188
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.90237942
33Hypoalphalipoproteinemia (HP:0003233)2.89260070
34Abnormality of complement system (HP:0005339)2.88659152
35Joint hemorrhage (HP:0005261)2.87850952
36Abnormality of sulfur amino acid metabolism (HP:0004339)2.84644269
37Hyperglycinemia (HP:0002154)2.83466637
38Generalized aminoaciduria (HP:0002909)2.78819641
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.76904478
40Achilles tendon contracture (HP:0001771)2.74774117
41Abnormality of the Achilles tendon (HP:0005109)2.70081580
42Myocardial infarction (HP:0001658)2.66974076
43Abnormality of macrophages (HP:0004311)2.65872845
44Fat malabsorption (HP:0002630)2.65367901
45Epidermoid cyst (HP:0200040)2.58655269
46Distal lower limb muscle weakness (HP:0009053)2.58587700
47Abnormality of purine metabolism (HP:0004352)2.58524493
48Purpura (HP:0000979)2.57016457
49Rough bone trabeculation (HP:0100670)2.55937112
50Mucopolysacchariduria (HP:0008155)2.54585494
51Urinary glycosaminoglycan excretion (HP:0003541)2.54585494
52Abnormality of the distal phalanges of the toes (HP:0010182)2.49555407
53Abnormality of nucleobase metabolism (HP:0010932)2.47816425
54Hyperglycemia (HP:0003074)2.46996717
55Abnormality of endocrine pancreas physiology (HP:0012093)2.44941987
56Abnormality of the pancreatic islet cells (HP:0006476)2.44941987
57Hepatosplenomegaly (HP:0001433)2.43200757
58Gout (HP:0001997)2.42146457
59Increased cerebral lipofuscin (HP:0011813)2.37894530
60Vacuolated lymphocytes (HP:0001922)2.37531256
61Hyperbilirubinemia (HP:0002904)2.36405125
62Recurrent abscess formation (HP:0002722)2.36004196
63Increased serum ferritin (HP:0003281)2.35634159
64Loss of speech (HP:0002371)2.34207405
65Abnormal cartilage morphology (HP:0002763)2.32967406
66Systemic lupus erythematosus (HP:0002725)2.32561051
67Symptomatic seizures (HP:0011145)2.32184220
68Hepatocellular carcinoma (HP:0001402)2.31165143
69Dysostosis multiplex (HP:0000943)2.30253573
70Ragged-red muscle fibers (HP:0003200)2.29776007
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29315160
72Dicarboxylic aciduria (HP:0003215)2.29315160
73Insulin resistance (HP:0000855)2.28664598
74Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28568311
75Petechiae (HP:0000967)2.27937017
76Skin nodule (HP:0200036)2.26481999
77Abnormality of pyrimidine metabolism (HP:0004353)2.26400291
78Trismus (HP:0000211)2.24694055
79Eczematoid dermatitis (HP:0000976)2.24688226
80Hypercholesterolemia (HP:0003124)2.24323660
81Abnormality of polysaccharide metabolism (HP:0011012)2.23000029
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.23000029
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.23000029
84Spastic diplegia (HP:0001264)2.21729307
85Prolonged neonatal jaundice (HP:0006579)2.20490729
86Progressive neurologic deterioration (HP:0002344)2.20229720
87Multiple enchondromatosis (HP:0005701)2.15188348
88Conjugated hyperbilirubinemia (HP:0002908)2.15133413
89Amyloidosis (HP:0011034)2.13427656
90Abnormal trabecular bone morphology (HP:0100671)2.12593066
91Abnormality of methionine metabolism (HP:0010901)2.11879631
92J-shaped sella turcica (HP:0002680)2.11823921
93Distal upper limb amyotrophy (HP:0007149)2.07723497
94Upper limb amyotrophy (HP:0009129)2.07723497
95Esophageal varix (HP:0002040)2.07682423
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.07312641
97Recurrent gram-negative bacterial infections (HP:0005420)2.06266703
98Short nail (HP:0001799)2.04804542
99Hypokinesia (HP:0002375)2.04377570
100Pancreatitis (HP:0001733)2.01648713
101Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00435168
102Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00435168
103Pancreatic islet-cell hyperplasia (HP:0004510)2.00000476
104Nonimmune hydrops fetalis (HP:0001790)1.98932365
105Recurrent bacterial skin infections (HP:0005406)1.98840186
106Hypertensive crisis (HP:0100735)1.98309767
107Hemorrhage of the eye (HP:0011885)1.98116574
108Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97959427
109Obstructive lung disease (HP:0006536)1.97290110
110Chronic obstructive pulmonary disease (HP:0006510)1.97290110
111Cellulitis (HP:0100658)1.95485208
112Protrusio acetabuli (HP:0003179)1.92702427
113Abnormality of the umbilical cord (HP:0010881)1.92230627
114Hand muscle atrophy (HP:0009130)1.89904372
115Abnormality of transition element cation homeostasis (HP:0011030)1.89798027
116Proximal tubulopathy (HP:0000114)1.88272252
117Entropion (HP:0000621)1.87661339
118Hydroxyprolinuria (HP:0003080)1.87278054
119Abnormality of proline metabolism (HP:0010907)1.87278054
120Mitral stenosis (HP:0001718)1.87277173
121Axonal loss (HP:0003447)1.86923548
122Thrombocytosis (HP:0001894)1.86518187
123Back pain (HP:0003418)1.86132205
124Polycythemia (HP:0001901)1.85433994
125Elbow flexion contracture (HP:0002987)1.84837587
126Nausea (HP:0002018)1.84496381
127Biconcave vertebral bodies (HP:0004586)1.84303759
128Abnormality of serum amino acid levels (HP:0003112)1.83684709
129Interstitial pulmonary disease (HP:0006530)1.83469937
130Myoglobinuria (HP:0002913)1.82994181
131Fasciculations (HP:0002380)1.82685459
132Abnormal enzyme/coenzyme activity (HP:0012379)1.81903695
133Osteolytic defects of the phalanges of the hand (HP:0009771)1.80931482
134Osteolytic defects of the hand bones (HP:0009699)1.80931482
135Generalized amyotrophy (HP:0003700)1.80226957
136Glomerulonephritis (HP:0000099)1.80040478
137Steatorrhea (HP:0002570)1.79955720
138Hypertriglyceridemia (HP:0002155)1.77383194
139Metabolic acidosis (HP:0001942)1.75547594
140Delayed CNS myelination (HP:0002188)1.75316898
141Flat acetabular roof (HP:0003180)1.75287329
142Abnormality of carpal bone ossification (HP:0006257)1.74735139
143Menorrhagia (HP:0000132)1.74359550
144Progressive muscle weakness (HP:0003323)1.74259834
145Insulin-resistant diabetes mellitus (HP:0000831)1.74156895
146Bone pain (HP:0002653)1.72167219
147Type I transferrin isoform profile (HP:0003642)1.71345112
148Abnormality of iron homeostasis (HP:0011031)1.71110229
149Cervical subluxation (HP:0003308)1.70744255
150Upper motor neuron abnormality (HP:0002127)1.70069375
151Cerebral aneurysm (HP:0004944)1.69447212
152Protuberant abdomen (HP:0001538)1.69276922
153Blue sclerae (HP:0000592)1.69016653
154Microvesicular hepatic steatosis (HP:0001414)1.68599361
155Beaking of vertebral bodies (HP:0004568)1.68271852
156Gingival bleeding (HP:0000225)1.67941929
157Abnormality of alkaline phosphatase activity (HP:0004379)1.67896661
158Reduced antithrombin III activity (HP:0001976)1.66812233
159Abnormal platelet function (HP:0011869)1.66360351
160Impaired platelet aggregation (HP:0003540)1.66360351
161Elevated alkaline phosphatase (HP:0003155)1.66278084
162Polygenic inheritance (HP:0010982)1.65689652
163Irritability (HP:0000737)1.65480398
164Joint stiffness (HP:0001387)1.63697631
165Cholelithiasis (HP:0001081)1.62574606
166Nuclear cataract (HP:0100018)1.61847308
167Elevated erythrocyte sedimentation rate (HP:0003565)1.59829998
168Microretrognathia (HP:0000308)1.59153369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.63640498
2TRIB34.52820648
3BCKDK3.50647702
4PKN23.20221325
5SMG12.85522219
6VRK22.57389934
7SIK12.53189593
8TAOK32.44196412
9FLT32.18470007
10FGFR42.15054841
11MAP3K102.08414337
12EEF2K2.01591059
13KDR2.00678871
14SCYL21.92007289
15ARAF1.90892436
16PTK61.87412386
17TAOK21.86995794
18PRPF4B1.81835102
19PASK1.69401071
20IRAK31.67689499
21LRRK21.62498658
22MAP4K11.59054759
23INSRR1.54452083
24TYK21.47646693
25NME21.45762028
26LIMK11.41935282
27MAP2K31.38674734
28EPHA21.37707427
29PIK3CG1.33590956
30TESK21.29771698
31ICK1.29111177
32ZAP701.27465980
33TBK11.19980569
34RPS6KA41.18882451
35MAP3K31.15567953
36PAK41.12807461
37JAK31.10370897
38NEK91.09707017
39FRK1.09426033
40TTN1.06097261
41TGFBR21.04518608
42MST1R1.03831722
43RIPK11.03577044
44STK101.03166124
45MAPKAPK31.00877280
46PBK0.99939704
47PDGFRA0.99444276
48LMTK20.98619272
49JAK10.95416868
50TESK10.92015917
51EPHB10.91717270
52STK160.90930618
53JAK20.89690797
54TIE10.89281444
55MAPK110.88853293
56BTK0.88569109
57CDK60.88353803
58MAP3K110.87181917
59EIF2AK30.86580880
60MAP3K80.84425481
61NEK20.83246202
62BLK0.82854764
63CDK40.81837776
64PDK20.81758348
65RPS6KB20.81678161
66CAMK1D0.81572740
67AURKA0.81297085
68BRSK20.79817930
69CDK70.79167296
70EIF2AK10.77023822
71MAP2K20.76990022
72TAOK10.76776814
73GRK60.76331401
74LATS10.75571718
75BRAF0.74415058
76MTOR0.71941849
77PTK20.71090389
78DAPK10.70598621
79TGFBR10.69999291
80EPHA30.68107692
81CDK120.67806516
82DYRK1B0.66455032
83MAP3K140.66047257
84NEK10.64305300
85FGFR30.63786182
86CSK0.60844127
87MET0.60478959
88CSF1R0.59980933
89SRPK10.59650453
90BUB10.59633399
91ABL20.57677002
92WEE10.57387994
93PAK10.57341173
94HIPK20.56464954
95ITK0.55656988
96MAPKAPK20.55582813
97IKBKB0.55252814
98KIT0.54415973
99TLK10.54244509
100TEC0.54225437
101BMX0.53376103
102MOS0.53140782
103MAP3K10.52262194
104PDPK10.50775158
105PAK20.50404729
106PIM10.49631399
107CLK10.49516028
108MAP3K120.48498393
109PIM20.48395221
110DAPK30.45576179
111CDK80.45033011
112STK30.44405807
113ILK0.40970515
114PRKCI0.40041514
115BRSK10.39754638
116IKBKE0.39594285
117IRAK40.38460483
118PRKD20.36856613
119SIK30.36734569
120MATK0.36576821
121MYLK0.35169461
122AURKB0.34967686
123ERBB40.34823211
124IRAK20.34102665
125CHUK0.33024999
126STK40.32356200
127PRKAA20.32229667
128ACVR1B0.32049279
129FES0.31736233
130DYRK30.31428063
131PRKG20.30498949
132TTK0.30327763
133CDC42BPA0.29886293
134GSK3A0.29224063
135MAPK150.28960669
136AKT20.28397692
137ALK0.25414325
138MAP3K70.25373128
139NLK0.25194458
140PRKAA10.24995932

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.10404752
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93051730
3Nitrogen metabolism_Homo sapiens_hsa009102.77341555
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.59464052
5Proteasome_Homo sapiens_hsa030502.57639762
6Fatty acid degradation_Homo sapiens_hsa000712.49079514
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.40700230
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36453840
9Tryptophan metabolism_Homo sapiens_hsa003802.34798909
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34731175
11Selenocompound metabolism_Homo sapiens_hsa004502.25177271
12Arginine biosynthesis_Homo sapiens_hsa002202.14407977
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.07704273
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05268266
15Complement and coagulation cascades_Homo sapiens_hsa046102.04357457
16Caffeine metabolism_Homo sapiens_hsa002321.84243638
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83484843
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.82739666
19PPAR signaling pathway_Homo sapiens_hsa033201.74554084
20Propanoate metabolism_Homo sapiens_hsa006401.74282519
21Peroxisome_Homo sapiens_hsa041461.67840167
22Folate biosynthesis_Homo sapiens_hsa007901.66436249
23Sulfur metabolism_Homo sapiens_hsa009201.65838411
24Fatty acid metabolism_Homo sapiens_hsa012121.65753204
25Base excision repair_Homo sapiens_hsa034101.62564785
26Fat digestion and absorption_Homo sapiens_hsa049751.57333095
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56438494
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54226967
29Staphylococcus aureus infection_Homo sapiens_hsa051501.51926994
30One carbon pool by folate_Homo sapiens_hsa006701.50151890
31beta-Alanine metabolism_Homo sapiens_hsa004101.48072852
32* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.47219618
33Carbon metabolism_Homo sapiens_hsa012001.46537232
34Biosynthesis of amino acids_Homo sapiens_hsa012301.38528993
35Starch and sucrose metabolism_Homo sapiens_hsa005001.35820551
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35030440
37Histidine metabolism_Homo sapiens_hsa003401.35015538
38Butanoate metabolism_Homo sapiens_hsa006501.34893562
39Vibrio cholerae infection_Homo sapiens_hsa051101.31813370
40Sulfur relay system_Homo sapiens_hsa041221.30084909
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27122067
42Pentose phosphate pathway_Homo sapiens_hsa000301.24941634
43Pyruvate metabolism_Homo sapiens_hsa006201.23058754
44Chemical carcinogenesis_Homo sapiens_hsa052041.18143190
45Phenylalanine metabolism_Homo sapiens_hsa003601.17578552
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17510967
47ABC transporters_Homo sapiens_hsa020101.16707184
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15362309
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.12517363
50Shigellosis_Homo sapiens_hsa051311.11494775
51Protein export_Homo sapiens_hsa030601.08343867
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05747781
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05258133
54Bile secretion_Homo sapiens_hsa049760.99335506
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99179840
56Retinol metabolism_Homo sapiens_hsa008300.97213365
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.96523098
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.96309669
59Tyrosine metabolism_Homo sapiens_hsa003500.94752535
60Lysine degradation_Homo sapiens_hsa003100.94543364
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94101155
62Galactose metabolism_Homo sapiens_hsa000520.93415907
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.92909854
64Other glycan degradation_Homo sapiens_hsa005110.92520416
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91715548
66Salmonella infection_Homo sapiens_hsa051320.87749813
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87015676
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86760950
69Spliceosome_Homo sapiens_hsa030400.84464537
70Apoptosis_Homo sapiens_hsa042100.84289221
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84287407
72N-Glycan biosynthesis_Homo sapiens_hsa005100.84195284
73Vitamin digestion and absorption_Homo sapiens_hsa049770.79344626
74Autoimmune thyroid disease_Homo sapiens_hsa053200.78790142
75Arginine and proline metabolism_Homo sapiens_hsa003300.78599926
76Mismatch repair_Homo sapiens_hsa034300.77344791
77Insulin resistance_Homo sapiens_hsa049310.76950951
78Lysosome_Homo sapiens_hsa041420.76923785
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.76245679
80Allograft rejection_Homo sapiens_hsa053300.76219973
81Glycerolipid metabolism_Homo sapiens_hsa005610.75825845
82Leishmaniasis_Homo sapiens_hsa051400.74666983
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71918486
84Antigen processing and presentation_Homo sapiens_hsa046120.70427128
85Pertussis_Homo sapiens_hsa051330.69550236
86Glutathione metabolism_Homo sapiens_hsa004800.68824542
87Viral myocarditis_Homo sapiens_hsa054160.68655158
88Fructose and mannose metabolism_Homo sapiens_hsa000510.67905520
89Herpes simplex infection_Homo sapiens_hsa051680.67742333
90Phagosome_Homo sapiens_hsa041450.64993389
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63961427
92Primary immunodeficiency_Homo sapiens_hsa053400.61844151
93Epstein-Barr virus infection_Homo sapiens_hsa051690.59994851
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58454161
95Graft-versus-host disease_Homo sapiens_hsa053320.58360778
96Hepatitis C_Homo sapiens_hsa051600.57741514
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57626143
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.56246802
99Influenza A_Homo sapiens_hsa051640.56121467
100Osteoclast differentiation_Homo sapiens_hsa043800.55566058
101Oxidative phosphorylation_Homo sapiens_hsa001900.53980113
102Rheumatoid arthritis_Homo sapiens_hsa053230.51605446
103Nucleotide excision repair_Homo sapiens_hsa034200.51321758
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51181125
105Fatty acid elongation_Homo sapiens_hsa000620.50969071
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50472954
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49858843
108RNA polymerase_Homo sapiens_hsa030200.49171673
109Sphingolipid metabolism_Homo sapiens_hsa006000.47535149
110Viral carcinogenesis_Homo sapiens_hsa052030.45671945
111Renin-angiotensin system_Homo sapiens_hsa046140.45137496
112Legionellosis_Homo sapiens_hsa051340.44924298
113DNA replication_Homo sapiens_hsa030300.43442580
114Toxoplasmosis_Homo sapiens_hsa051450.42917272
115Tuberculosis_Homo sapiens_hsa051520.41899528
116Pancreatic cancer_Homo sapiens_hsa052120.41070262
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41056638
118Vitamin B6 metabolism_Homo sapiens_hsa007500.36653699
119Metabolic pathways_Homo sapiens_hsa011000.35982350
120AMPK signaling pathway_Homo sapiens_hsa041520.32696634
121Bladder cancer_Homo sapiens_hsa052190.32551206
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31682850
123Prion diseases_Homo sapiens_hsa050200.27811105
124Protein digestion and absorption_Homo sapiens_hsa049740.24605694
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.23795793
126Fatty acid biosynthesis_Homo sapiens_hsa000610.23520872
127Glucagon signaling pathway_Homo sapiens_hsa049220.22394798
128Small cell lung cancer_Homo sapiens_hsa052220.21060490
129Pyrimidine metabolism_Homo sapiens_hsa002400.19228145
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19023489
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18043659
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17750140
133Insulin signaling pathway_Homo sapiens_hsa049100.17708345
134Acute myeloid leukemia_Homo sapiens_hsa052210.15841549
135Chronic myeloid leukemia_Homo sapiens_hsa052200.15468325
136Ribosome_Homo sapiens_hsa030100.14276571
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13992361
138Thyroid cancer_Homo sapiens_hsa052160.12274397
139Systemic lupus erythematosus_Homo sapiens_hsa053220.10109406

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