LMBR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.29973402
2nuclear pore organization (GO:0006999)5.80361517
3neuron cell-cell adhesion (GO:0007158)5.08143517
4presynaptic membrane assembly (GO:0097105)4.90441393
5pore complex assembly (GO:0046931)4.57854847
6presynaptic membrane organization (GO:0097090)4.50997263
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.50758316
8vocalization behavior (GO:0071625)4.44038303
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.23081538
10mitotic sister chromatid cohesion (GO:0007064)4.17118230
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.07770169
12regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.02431743
13postsynaptic membrane organization (GO:0001941)4.00599534
14protein localization to synapse (GO:0035418)3.98811571
15synaptic vesicle exocytosis (GO:0016079)3.98123919
16regulation of centriole replication (GO:0046599)3.96227979
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.93040494
18regulation of glutamate receptor signaling pathway (GO:1900449)3.80873224
19gamma-aminobutyric acid transport (GO:0015812)3.75499164
20neuron recognition (GO:0008038)3.65591135
21DNA unwinding involved in DNA replication (GO:0006268)3.65148365
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.64260207
23regulation of synaptic vesicle exocytosis (GO:2000300)3.61717991
24glutamate receptor signaling pathway (GO:0007215)3.60625876
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.51621694
26synaptic vesicle maturation (GO:0016188)3.39742099
27synaptic transmission, glutamatergic (GO:0035249)3.39431604
28G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.38433483
29response to redox state (GO:0051775)3.35665117
30cytoplasmic mRNA processing body assembly (GO:0033962)3.35334548
31neuronal action potential propagation (GO:0019227)3.34636976
32glutamate secretion (GO:0014047)3.34364190
33axonal fasciculation (GO:0007413)3.32911117
34positive regulation of dendritic spine morphogenesis (GO:0061003)3.31293045
35neuron-neuron synaptic transmission (GO:0007270)3.30928551
36layer formation in cerebral cortex (GO:0021819)3.30682056
37regulation of synaptic vesicle transport (GO:1902803)3.25464513
38neurotransmitter-gated ion channel clustering (GO:0072578)3.22972147
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.22927801
40regulation of sister chromatid cohesion (GO:0007063)3.22426148
41interkinetic nuclear migration (GO:0022027)3.19343043
42positive regulation of synapse assembly (GO:0051965)3.17936509
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.15856853
44regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15613268
45negative regulation of neurotransmitter transport (GO:0051589)3.13674194
46regulation of RNA export from nucleus (GO:0046831)3.13317287
47positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.12965409
48paraxial mesoderm development (GO:0048339)3.12546300
49membrane hyperpolarization (GO:0060081)3.11758170
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.09555923
51positive regulation of synaptic transmission, GABAergic (GO:0032230)3.08293931
52dendritic spine morphogenesis (GO:0060997)3.06252949
53regulation of postsynaptic membrane potential (GO:0060078)3.05980320
54startle response (GO:0001964)3.04212371
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.03797347
56embryonic foregut morphogenesis (GO:0048617)3.02029942
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00833409
58transmission of nerve impulse (GO:0019226)2.98789366
59response to pheromone (GO:0019236)2.98104861
60regulation of respiratory system process (GO:0044065)2.95901423
61negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95583381
62innervation (GO:0060384)2.95163999
63dendrite morphogenesis (GO:0048813)2.92279855
64synaptic vesicle endocytosis (GO:0048488)2.91875500
65protein localization to cilium (GO:0061512)2.90199736
66regulation of neuronal synaptic plasticity (GO:0048168)2.89176249
67locomotory exploration behavior (GO:0035641)2.87609998
68mitotic chromosome condensation (GO:0007076)2.87010854
69regulation of centrosome duplication (GO:0010824)2.86847104
70synapse assembly (GO:0007416)2.86300271
71regulation of long-term neuronal synaptic plasticity (GO:0048169)2.86187238
72synaptic vesicle docking involved in exocytosis (GO:0016081)2.85351848
73regulation of synapse assembly (GO:0051963)2.85062862
74response to auditory stimulus (GO:0010996)2.84571136
75regulation of centrosome cycle (GO:0046605)2.84483435
76membrane assembly (GO:0071709)2.83974728
77exploration behavior (GO:0035640)2.83771759
78regulation of respiratory gaseous exchange (GO:0043576)2.82717325
79regulation of dendritic spine morphogenesis (GO:0061001)2.80754648
80central nervous system myelination (GO:0022010)2.80743942
81axon ensheathment in central nervous system (GO:0032291)2.80743942
82central nervous system projection neuron axonogenesis (GO:0021952)2.79628205
83dendrite development (GO:0016358)2.79269596
84long-term synaptic potentiation (GO:0060291)2.78402320
85positive regulation of membrane potential (GO:0045838)2.77652423
86regulation of neurotransmitter secretion (GO:0046928)2.75877359
87neurotransmitter secretion (GO:0007269)2.74629519
88cell migration in hindbrain (GO:0021535)2.73204743
89cerebellar granule cell differentiation (GO:0021707)2.73099974
90regulation of synapse structural plasticity (GO:0051823)2.72393513
91calcium ion-dependent exocytosis (GO:0017156)2.70531741
92righting reflex (GO:0060013)2.70232590
93membrane depolarization (GO:0051899)2.69365896
94auditory behavior (GO:0031223)2.68244598
95regulation of dendritic spine development (GO:0060998)2.66979468
96establishment of mitochondrion localization (GO:0051654)2.66791945
97cerebral cortex radially oriented cell migration (GO:0021799)2.66531805
98regulation of synaptic transmission, GABAergic (GO:0032228)2.66416366
99L-amino acid import (GO:0043092)2.65901453
100negative regulation of neurotransmitter secretion (GO:0046929)2.65157469
101sister chromatid segregation (GO:0000819)2.63920019
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.63671712
103membrane depolarization during action potential (GO:0086010)2.63663796
104learning (GO:0007612)2.63588410
105regulation of nucleobase-containing compound transport (GO:0032239)2.61329504
106vesicle transport along microtubule (GO:0047496)2.60863251
107long-term memory (GO:0007616)2.60826454
108detection of calcium ion (GO:0005513)2.60541481
109mechanosensory behavior (GO:0007638)2.59672613
110cellular potassium ion homeostasis (GO:0030007)2.59345753
111behavioral defense response (GO:0002209)2.58246504
112behavioral fear response (GO:0001662)2.58246504
113organelle transport along microtubule (GO:0072384)2.56500252
114adult walking behavior (GO:0007628)2.55899264
115peptidyl-lysine dimethylation (GO:0018027)2.55775413
116response to histamine (GO:0034776)2.54192939
117neurotransmitter transport (GO:0006836)2.53946184
118urinary tract smooth muscle contraction (GO:0014848)2.52226181
119regulation of neurotransmitter transport (GO:0051588)2.52219729
120embryonic camera-type eye morphogenesis (GO:0048596)2.51195714
121protein localization to chromosome, centromeric region (GO:0071459)2.46898708
122dosage compensation (GO:0007549)2.46178527
123microtubule anchoring (GO:0034453)2.46116438
124DNA duplex unwinding (GO:0032508)2.42471209
125DNA geometric change (GO:0032392)2.42056815
126inositol metabolic process (GO:0006020)2.41491828
127DNA topological change (GO:0006265)2.39872923
128regulation of NFAT protein import into nucleus (GO:0051532)2.39152378
129DNA replication initiation (GO:0006270)2.38787238
130regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.36484095
131nucleus localization (GO:0051647)2.35559661
132protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.31286800
133mitotic spindle organization (GO:0007052)2.31175573
134pre-miRNA processing (GO:0031054)2.29742518
135establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.29483075
136mitochondrion transport along microtubule (GO:0047497)2.29483075
137regulation of translational fidelity (GO:0006450)2.29384188
138DNA synthesis involved in DNA repair (GO:0000731)2.29369146
139glucocorticoid receptor signaling pathway (GO:0042921)2.28512824
140cellular protein complex localization (GO:0034629)2.27816054
141nucleus organization (GO:0006997)2.27336482
142peptidyl-threonine dephosphorylation (GO:0035970)2.26711035
143embryonic heart tube development (GO:0035050)2.25589438
144protein export from nucleus (GO:0006611)2.23651502
145morphogenesis of an epithelial sheet (GO:0002011)2.21286964
146positive regulation of male gonad development (GO:2000020)2.20933726
147sister chromatid cohesion (GO:0007062)2.20635186
148Golgi to endosome transport (GO:0006895)2.20428255
149double-strand break repair via nonhomologous end joining (GO:0006303)2.17416919
150non-recombinational repair (GO:0000726)2.17416919
151embryonic eye morphogenesis (GO:0048048)2.17176615
152ectodermal placode formation (GO:0060788)2.16643118
153asymmetric protein localization (GO:0008105)2.16470032
154protein localization to microtubule cytoskeleton (GO:0072698)2.16116360
155gene silencing by RNA (GO:0031047)2.16052345
156peptidyl-arginine methylation (GO:0018216)2.16046229
157peptidyl-arginine N-methylation (GO:0035246)2.16046229
158apical protein localization (GO:0045176)2.15624462
159positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.13251549
160positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.13251549
161positive regulation of mitotic sister chromatid separation (GO:1901970)2.13251549
162mitotic sister chromatid segregation (GO:0000070)2.12774838
163NLS-bearing protein import into nucleus (GO:0006607)2.11100048
164embryonic retina morphogenesis in camera-type eye (GO:0060059)2.09993447
165protein localization to chromosome (GO:0034502)2.09940827
166regulation of DNA endoreduplication (GO:0032875)2.09487978
167histone H2B ubiquitination (GO:0033523)2.09078757
168negative regulation of DNA repair (GO:0045738)2.07401607
169peptidyl-arginine omega-N-methylation (GO:0035247)2.06542589
170somatic diversification of immune receptors via somatic mutation (GO:0002566)2.05733245
171somatic hypermutation of immunoglobulin genes (GO:0016446)2.05733245
172DNA conformation change (GO:0071103)2.05593115
173sex differentiation (GO:0007548)2.03529026
174regulation of transforming growth factor beta2 production (GO:0032909)2.02050877
175establishment of nucleus localization (GO:0040023)2.01870368
176gastrulation with mouth forming second (GO:0001702)1.99958270
177COPII vesicle coating (GO:0048208)1.99817834
178protein localization to microtubule (GO:0035372)1.99731223
179spindle organization (GO:0007051)1.97925363
180mitotic nuclear envelope disassembly (GO:0007077)1.97651071
181membrane disassembly (GO:0030397)1.94841335
182nuclear envelope disassembly (GO:0051081)1.94841335
183labyrinthine layer development (GO:0060711)1.94721902
184glucocorticoid biosynthetic process (GO:0006704)1.94071973
185endoplasmic reticulum organization (GO:0007029)1.93207894
186protein complex localization (GO:0031503)1.92844087
187peptidyl-threonine modification (GO:0018210)1.92709123
188positive regulation of cell cycle checkpoint (GO:1901978)1.92007999
189DNA strand elongation (GO:0022616)1.91129951
190DNA replication-dependent nucleosome assembly (GO:0006335)1.90422154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.74323933
2EZH2_22144423_ChIP-Seq_EOC_Human4.63382009
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.18415691
4GBX2_23144817_ChIP-Seq_PC3_Human3.97192364
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.39115902
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.87652736
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.76159982
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56906604
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48214723
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44729335
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42706663
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42311419
13PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.34521661
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29223004
15TAF15_26573619_Chip-Seq_HEK293_Human2.27947502
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20953136
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20877245
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17084787
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.16079366
20AR_21909140_ChIP-Seq_LNCAP_Human2.15986704
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.14802465
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11092616
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11092616
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06020418
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01937504
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97965776
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.96031482
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.94340677
29REST_21632747_ChIP-Seq_MESCs_Mouse1.93898375
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93333649
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88640887
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.86369158
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.85792599
34AR_21572438_ChIP-Seq_LNCaP_Human1.83456031
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81298815
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79988055
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79001551
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.78453878
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78049474
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77983383
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.77673711
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76908675
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75822990
44P300_19829295_ChIP-Seq_ESCs_Human1.74885615
45SMAD4_21799915_ChIP-Seq_A2780_Human1.73586219
46DROSHA_22980978_ChIP-Seq_HELA_Human1.69911849
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69527710
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69198659
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.68973435
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.68111122
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68034667
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64310320
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60907327
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.58826107
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58227084
56RNF2_27304074_Chip-Seq_NSC_Mouse1.55710414
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54722659
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.53536672
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50876829
60FUS_26573619_Chip-Seq_HEK293_Human1.50636150
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.50268846
62* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49850878
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.45510000
64VDR_22108803_ChIP-Seq_LS180_Human1.45102387
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44700691
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43893546
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43831264
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43374086
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.41865425
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.41188152
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40768913
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40290810
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40070098
74ER_23166858_ChIP-Seq_MCF-7_Human1.39737319
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39500384
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.39183573
77AR_25329375_ChIP-Seq_VCAP_Human1.39161042
78* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39068463
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.38966165
80* STAT3_23295773_ChIP-Seq_U87_Human1.38316746
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.37583527
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36814087
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36781015
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36543196
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36462398
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34787358
87MYC_18555785_ChIP-Seq_MESCs_Mouse1.34783561
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.32262457
89ZNF274_21170338_ChIP-Seq_K562_Hela1.32069336
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30651017
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.28927381
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28398929
93YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26990630
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.25251664
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25102451
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25102451
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.24134500
98IGF1R_20145208_ChIP-Seq_DFB_Human1.22126609
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21844646
100* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21681826
101* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20973095
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20761298
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20691027
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.20634489
105CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20595671
106TCF4_23295773_ChIP-Seq_U87_Human1.20583456
107P53_22387025_ChIP-Seq_ESCs_Mouse1.20301843
108* SOX2_21211035_ChIP-Seq_LN229_Gbm1.19759703
109SOX9_26525672_Chip-Seq_HEART_Mouse1.19082793
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.16984807
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16908723
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16778611
113* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16695391
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16070856
115CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14792065
116SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13325356
117AHR_22903824_ChIP-Seq_MCF-7_Human1.12970767
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12956366
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.12415001
120TP53_18474530_ChIP-ChIP_U2OS_Human1.12010895
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11903231
122RUNX2_22187159_ChIP-Seq_PCA_Human1.11291937
123NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10832897
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10803954
125TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10218328
126MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09926594
127SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09254741
128TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09088698
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08605672
130TP53_16413492_ChIP-PET_HCT116_Human1.07861583
131KDM2B_26808549_Chip-Seq_REH_Human1.07716891
132NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07271509
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06665584
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06362168
135* PRDM14_20953172_ChIP-Seq_ESCs_Human1.06273770
136BCAT_22108803_ChIP-Seq_LS180_Human1.04615912
137STAT3_18555785_Chip-Seq_ESCs_Mouse1.02575325
138RING1B_27294783_Chip-Seq_ESCs_Mouse1.02504931
139EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01946877
140P300_18555785_Chip-Seq_ESCs_Mouse1.01601676
141TAL1_26923725_Chip-Seq_HPCs_Mouse1.00367157
142EWS_26573619_Chip-Seq_HEK293_Human1.00278483
143NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99708541
144STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98939032
145HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97948477
146DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97225676
147IRF1_19129219_ChIP-ChIP_H3396_Human0.95938547
148FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93436301
149ELK1_19687146_ChIP-ChIP_HELA_Human0.89909896
150GATA1_26923725_Chip-Seq_HPCs_Mouse0.89740308
151AR_19668381_ChIP-Seq_PC3_Human0.88901578
152ISL1_27105846_Chip-Seq_CPCs_Mouse0.87333818
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86310668
154POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.84249318
155CHD1_26751641_Chip-Seq_LNCaP_Human0.84128239
156REST_19997604_ChIP-ChIP_NEURONS_Mouse0.83209244
157* ZNF263_19887448_ChIP-Seq_K562_Human0.82087666
158NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81624476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.51731784
2MP0008057_abnormal_DNA_replication4.06311892
3MP0004859_abnormal_synaptic_plasticity3.89382250
4MP0005423_abnormal_somatic_nervous3.42040938
5MP0004270_analgesia3.34103953
6MP0003635_abnormal_synaptic_transmissio3.13017984
7MP0002009_preneoplasia2.91774651
8MP0002063_abnormal_learning/memory/cond2.70810991
9MP0001968_abnormal_touch/_nociception2.66902799
10MP0009745_abnormal_behavioral_response2.62344349
11MP0009046_muscle_twitch2.42134970
12MP0002064_seizures2.41787728
13MP0001984_abnormal_olfaction2.39586325
14MP0006276_abnormal_autonomic_nervous2.35728634
15MP0002734_abnormal_mechanical_nocicepti2.35700859
16MP0000778_abnormal_nervous_system2.33750611
17MP0002736_abnormal_nociception_after2.32997812
18MP0002272_abnormal_nervous_system2.31981082
19MP0002572_abnormal_emotion/affect_behav2.31552018
20MP0001486_abnormal_startle_reflex2.31102749
21MP0002735_abnormal_chemical_nociception2.31022460
22MP0000569_abnormal_digit_pigmentation2.26625349
23MP0001529_abnormal_vocalization2.24468434
24MP0005646_abnormal_pituitary_gland2.03951761
25MP0004233_abnormal_muscle_weight2.00439782
26MP0000537_abnormal_urethra_morphology1.96263404
27MP0001501_abnormal_sleep_pattern1.93883555
28MP0005645_abnormal_hypothalamus_physiol1.93009732
29MP0002067_abnormal_sensory_capabilities1.91192594
30MP0000383_abnormal_hair_follicle1.91161550
31MP0001188_hyperpigmentation1.90165795
32MP0010678_abnormal_skin_adnexa1.89880457
33MP0010094_abnormal_chromosome_stability1.87364209
34MP0002184_abnormal_innervation1.86385415
35MP0010234_abnormal_vibrissa_follicle1.79263116
36MP0001440_abnormal_grooming_behavior1.78643255
37MP0003890_abnormal_embryonic-extraembry1.74689424
38MP0010352_gastrointestinal_tract_polyps1.74072558
39MP0002877_abnormal_melanocyte_morpholog1.73310922
40MP0000566_synostosis1.72391816
41MP0002733_abnormal_thermal_nociception1.71915810
42MP0009697_abnormal_copulation1.70660238
43MP0003111_abnormal_nucleus_morphology1.70391744
44MP0005386_behavior/neurological_phenoty1.67988320
45MP0004924_abnormal_behavior1.67988320
46MP0001502_abnormal_circadian_rhythm1.65748081
47MP0001905_abnormal_dopamine_level1.61186697
48MP0001970_abnormal_pain_threshold1.60460439
49MP0005410_abnormal_fertilization1.59002639
50MP0003937_abnormal_limbs/digits/tail_de1.57410608
51MP0005551_abnormal_eye_electrophysiolog1.56504350
52MP0002557_abnormal_social/conspecific_i1.56361118
53MP0003077_abnormal_cell_cycle1.52097848
54MP0005187_abnormal_penis_morphology1.45925875
55MP0010368_abnormal_lymphatic_system1.45076176
56MP0005171_absent_coat_pigmentation1.44948901
57MP0002822_catalepsy1.41081097
58MP0000955_abnormal_spinal_cord1.40585199
59MP0000427_abnormal_hair_cycle1.38743299
60MP0004145_abnormal_muscle_electrophysio1.37419538
61MP0001986_abnormal_taste_sensitivity1.36580552
62MP0002697_abnormal_eye_size1.36090801
63MP0003329_amyloid_beta_deposits1.36005743
64MP0002882_abnormal_neuron_morphology1.35815098
65MP0008058_abnormal_DNA_repair1.35172875
66MP0002234_abnormal_pharynx_morphology1.33290793
67MP0004957_abnormal_blastocyst_morpholog1.33206981
68MP0002084_abnormal_developmental_patter1.32547414
69MP0004858_abnormal_nervous_system1.30956637
70MP0003693_abnormal_embryo_hatching1.30767773
71MP0003122_maternal_imprinting1.30472115
72MP0003984_embryonic_growth_retardation1.28784992
73MP0003941_abnormal_skin_development1.27230375
74MP0000631_abnormal_neuroendocrine_gland1.26699491
75MP0008932_abnormal_embryonic_tissue1.26568675
76MP0001672_abnormal_embryogenesis/_devel1.26020492
77MP0005380_embryogenesis_phenotype1.26020492
78MP0010386_abnormal_urinary_bladder1.25036880
79MP0005076_abnormal_cell_differentiation1.24401484
80MP0008569_lethality_at_weaning1.24042512
81MP0006292_abnormal_olfactory_placode1.23147597
82MP0002088_abnormal_embryonic_growth/wei1.23052741
83MP0009780_abnormal_chondrocyte_physiolo1.22973494
84MP0003221_abnormal_cardiomyocyte_apopto1.21766694
85MP0001293_anophthalmia1.20774595
86MP0002066_abnormal_motor_capabilities/c1.20727725
87MP0004811_abnormal_neuron_physiology1.19801690
88MP0002092_abnormal_eye_morphology1.16466951
89MP0004142_abnormal_muscle_tone1.14757216
90MP0000462_abnormal_digestive_system1.14048587
91MP0003935_abnormal_craniofacial_develop1.12259695
92MP0004742_abnormal_vestibular_system1.12015151
93MP0004197_abnormal_fetal_growth/weight/1.10621721
94MP0004885_abnormal_endolymph1.10270631
95MP0003787_abnormal_imprinting1.09242384
96MP0001697_abnormal_embryo_size1.08309574
97MP0001730_embryonic_growth_arrest1.07955483
98MP0008877_abnormal_DNA_methylation1.07589906
99MP0002752_abnormal_somatic_nervous1.07338465
100MP0000579_abnormal_nail_morphology1.06797158
101MP0002085_abnormal_embryonic_tissue1.06428917
102MP0002152_abnormal_brain_morphology1.05968866
103MP0005623_abnormal_meninges_morphology1.05313374
104MP0000751_myopathy1.04397784
105MP0003879_abnormal_hair_cell1.04149968
106MP0003631_nervous_system_phenotype1.01875252
107MP0003633_abnormal_nervous_system1.01418024
108MP0002229_neurodegeneration1.01302264
109MP0003283_abnormal_digestive_organ1.00875010
110MP0003115_abnormal_respiratory_system0.99821058
111MP0004085_abnormal_heartbeat0.99193695
112MP0000350_abnormal_cell_proliferation0.98741496
113MP0000428_abnormal_craniofacial_morphol0.98542223
114MP0004484_altered_response_of0.98348056
115MP0002638_abnormal_pupillary_reflex0.98293663
116MP0005394_taste/olfaction_phenotype0.98113238
117MP0005499_abnormal_olfactory_system0.98113238
118MP0000534_abnormal_ureter_morphology0.97956598
119MP0002160_abnormal_reproductive_system0.97880430
120MP0000920_abnormal_myelination0.97394144
121MP0008995_early_reproductive_senescence0.96641533
122MP0001963_abnormal_hearing_physiology0.96072626
123MP0004215_abnormal_myocardial_fiber0.95999171
124MP0000013_abnormal_adipose_tissue0.95926384
125MP0002102_abnormal_ear_morphology0.95292209
126MP0002086_abnormal_extraembryonic_tissu0.94962102
127MP0003634_abnormal_glial_cell0.94488464
128MP0002909_abnormal_adrenal_gland0.93670754
129MP0009703_decreased_birth_body0.93114081
130MP0003942_abnormal_urinary_system0.92760982
131MP0002233_abnormal_nose_morphology0.91453776
132MP0002876_abnormal_thyroid_physiology0.90605389
133MP0002080_prenatal_lethality0.90149785
134MP0001286_abnormal_eye_development0.89843703
135MP0003632_abnormal_nervous_system0.89782403
136MP0003385_abnormal_body_wall0.89306599
137MP0003698_abnormal_male_reproductive0.87931468
138MP0001661_extended_life_span0.87445945
139MP0005409_darkened_coat_color0.87413782
140MP0000762_abnormal_tongue_morphology0.86960753
141MP0004272_abnormal_basement_membrane0.86882498
142MP0003567_abnormal_fetal_cardiomyocyte0.85937630
143MP0003943_abnormal_hepatobiliary_system0.84929900
144MP0003121_genomic_imprinting0.84790495
145MP0000647_abnormal_sebaceous_gland0.84611314
146MP0003136_yellow_coat_color0.83458041
147MP0004147_increased_porphyrin_level0.83296311
148MP0002081_perinatal_lethality0.83236702
149MP0000026_abnormal_inner_ear0.83115905
150MP0001879_abnormal_lymphatic_vessel0.82679346
151MP0002837_dystrophic_cardiac_calcinosis0.80597185
152MP0001485_abnormal_pinna_reflex0.79971435
153MP0002269_muscular_atrophy0.77487147
154MP0001340_abnormal_eyelid_morphology0.76891266
155MP0004134_abnormal_chest_morphology0.76723406
156MP0010307_abnormal_tumor_latency0.76191274
157MP0002098_abnormal_vibrissa_morphology0.76184016
158MP0003690_abnormal_glial_cell0.75970399
159MP0003755_abnormal_palate_morphology0.75618909
160MP0001177_atelectasis0.75456291
161MP0006072_abnormal_retinal_apoptosis0.74709048
162MP0009672_abnormal_birth_weight0.74152084
163MP0005253_abnormal_eye_physiology0.73927211
164MP0003137_abnormal_impulse_conducting0.73434593
165MP0005195_abnormal_posterior_eye0.72875268
166MP0004043_abnormal_pH_regulation0.71715119
167MP0002069_abnormal_eating/drinking_beha0.71248926
168MP0002090_abnormal_vision0.70312717
169MP0004036_abnormal_muscle_relaxation0.67408396
170MP0003861_abnormal_nervous_system0.66714946
171MP0002751_abnormal_autonomic_nervous0.65255184
172MP0001346_abnormal_lacrimal_gland0.62117276
173MP0001299_abnormal_eye_distance/0.62052766
174MP0005620_abnormal_muscle_contractility0.60975151
175MP0005595_abnormal_vascular_smooth0.60204294
176MP0003646_muscle_fatigue0.58363846

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.08105423
2Epileptic encephalopathy (HP:0200134)4.19073837
3Myokymia (HP:0002411)3.95627565
4Febrile seizures (HP:0002373)3.88412004
5Retinal dysplasia (HP:0007973)3.76271829
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.64952150
7Focal seizures (HP:0007359)3.63925414
8Hyperventilation (HP:0002883)3.58435848
9Progressive cerebellar ataxia (HP:0002073)3.46004028
10Papillary thyroid carcinoma (HP:0002895)3.41778441
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.28515129
12Absent/shortened dynein arms (HP:0200106)3.28515129
13Atonic seizures (HP:0010819)3.26409802
14Chromsome breakage (HP:0040012)3.06762624
15Broad-based gait (HP:0002136)2.94145607
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93279195
17Termporal pattern (HP:0011008)2.92269014
18Insidious onset (HP:0003587)2.92269014
19Abnormal respiratory motile cilium physiology (HP:0012261)2.71027888
20Thyroid carcinoma (HP:0002890)2.70923118
21Amblyopia (HP:0000646)2.64008933
22Drooling (HP:0002307)2.63506246
23Excessive salivation (HP:0003781)2.63506246
24Type II lissencephaly (HP:0007260)2.62427660
25Degeneration of the lateral corticospinal tracts (HP:0002314)2.60881490
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.60881490
27Absent speech (HP:0001344)2.59229528
28Dysmetric saccades (HP:0000641)2.57682877
29Gait imbalance (HP:0002141)2.56723137
30Abnormality of the corticospinal tract (HP:0002492)2.52964307
31Visual hallucinations (HP:0002367)2.49823802
32Medial flaring of the eyebrow (HP:0010747)2.49578209
33Septate vagina (HP:0001153)2.48994315
34Inability to walk (HP:0002540)2.47793885
35Absence seizures (HP:0002121)2.47773981
36Dialeptic seizures (HP:0011146)2.45897434
37Truncal ataxia (HP:0002078)2.45812260
38Progressive inability to walk (HP:0002505)2.45784401
39* Fibular aplasia (HP:0002990)2.45371011
40Generalized tonic-clonic seizures (HP:0002069)2.45191529
41Hemiparesis (HP:0001269)2.44566749
42Neurofibrillary tangles (HP:0002185)2.44444386
43Limb dystonia (HP:0002451)2.44343148
44Abnormal ciliary motility (HP:0012262)2.43331483
45Hypoplasia of the brainstem (HP:0002365)2.41114016
46Aplasia/Hypoplasia of the brainstem (HP:0007362)2.41114016
47Microglossia (HP:0000171)2.40782050
48Protruding tongue (HP:0010808)2.40085061
49Polyphagia (HP:0002591)2.36908707
50Increased nuchal translucency (HP:0010880)2.34511454
51Heterotopia (HP:0002282)2.33465920
52Asymmetry of the thorax (HP:0001555)2.28746969
53Action tremor (HP:0002345)2.28665010
54Cortical dysplasia (HP:0002539)2.28134642
55Supranuclear gaze palsy (HP:0000605)2.27746461
56Relative macrocephaly (HP:0004482)2.24225692
57Scanning speech (HP:0002168)2.23993261
58Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.22854779
59Thickened helices (HP:0000391)2.22776636
60Pheochromocytoma (HP:0002666)2.19916389
61Abnormal eating behavior (HP:0100738)2.18001758
62Congenital primary aphakia (HP:0007707)2.15740269
63Abnormal respiratory motile cilium morphology (HP:0005938)2.14613224
64Abnormal respiratory epithelium morphology (HP:0012253)2.14613224
65Urinary urgency (HP:0000012)2.14525202
66Gaze-evoked nystagmus (HP:0000640)2.14043357
67Ankle clonus (HP:0011448)2.14028267
68Dysmetria (HP:0001310)2.12190490
69Insomnia (HP:0100785)2.12129254
70Cubitus valgus (HP:0002967)2.11205075
71Renovascular hypertension (HP:0100817)2.09061828
72Dysdiadochokinesis (HP:0002075)2.06938157
73Nephroblastoma (Wilms tumor) (HP:0002667)2.04800891
74Genital tract atresia (HP:0001827)2.03727431
75Sandal gap (HP:0001852)2.01657871
76Vaginal atresia (HP:0000148)2.00650074
77Hyperacusis (HP:0010780)2.00089079
78Vertebral arch anomaly (HP:0008438)1.99871450
79Pancreatic fibrosis (HP:0100732)1.99721621
80Poor eye contact (HP:0000817)1.99265357
81Specific learning disability (HP:0001328)1.98643589
82Exotropia (HP:0000577)1.98642548
83Cerebral inclusion bodies (HP:0100314)1.97385537
84Mutism (HP:0002300)1.97111034
85Embryonal renal neoplasm (HP:0011794)1.96097560
86Epileptiform EEG discharges (HP:0011182)1.95637069
87Thyroid-stimulating hormone excess (HP:0002925)1.95575513
88Nephronophthisis (HP:0000090)1.95255722
89Humeroradial synostosis (HP:0003041)1.94797553
90Synostosis involving the elbow (HP:0003938)1.94797553
91Medulloblastoma (HP:0002885)1.93315092
92Abnormality of chromosome stability (HP:0003220)1.92784888
93Uterine leiomyosarcoma (HP:0002891)1.91388174
94Leiomyosarcoma (HP:0100243)1.91388174
95Partial agenesis of the corpus callosum (HP:0001338)1.91024769
96Nephrogenic diabetes insipidus (HP:0009806)1.90968482
97Intellectual disability, moderate (HP:0002342)1.90925800
98Blue irides (HP:0000635)1.90029442
99Lissencephaly (HP:0001339)1.89322173
100Septo-optic dysplasia (HP:0100842)1.88970556
101Central scotoma (HP:0000603)1.88854348
102Spastic gait (HP:0002064)1.87626587
103Deep philtrum (HP:0002002)1.87014193
104Missing ribs (HP:0000921)1.86474398
105Volvulus (HP:0002580)1.86218221
106Impaired vibration sensation in the lower limbs (HP:0002166)1.85288708
107Aplasia/Hypoplasia of the lens (HP:0008063)1.85036507
108Anxiety (HP:0000739)1.84698197
109EEG with generalized epileptiform discharges (HP:0011198)1.84361290
110Genetic anticipation (HP:0003743)1.81846973
111Abnormality of salivation (HP:0100755)1.81045834
112Morphological abnormality of the pyramidal tract (HP:0002062)1.80977794
113Rhinitis (HP:0012384)1.80695979
114Capillary hemangiomas (HP:0005306)1.79576726
115Hypoplastic pelvis (HP:0008839)1.78437257
116Esotropia (HP:0000565)1.77440963
117Elfin facies (HP:0004428)1.77287093
118Midline defect of the nose (HP:0004122)1.76862048
119Abnormal hair whorl (HP:0010721)1.76774300
120Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76262670
121High anterior hairline (HP:0009890)1.76006913
122Fibular hypoplasia (HP:0003038)1.75911744
123Neuroendocrine neoplasm (HP:0100634)1.75850972
124Lower limb muscle weakness (HP:0007340)1.75606015
125Acute necrotizing encephalopathy (HP:0006965)1.75113217
126Skull defect (HP:0001362)1.74914658
127Prolonged QT interval (HP:0001657)1.73565471
128Abnormality of the carotid arteries (HP:0005344)1.73495820
129Fetal akinesia sequence (HP:0001989)1.72834393
130Transitional cell carcinoma of the bladder (HP:0006740)1.72694242
131Overriding aorta (HP:0002623)1.72396727
132Widely spaced teeth (HP:0000687)1.68746880
133Germ cell neoplasia (HP:0100728)1.68543829
134Megalencephaly (HP:0001355)1.67766720
135Subacute progressive viral hepatitis (HP:0006572)1.67470710
136Muscle hypertrophy of the lower extremities (HP:0008968)1.65850262
137Optic nerve hypoplasia (HP:0000609)1.65531968
138Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65325507
139* Aplasia involving bones of the upper limbs (HP:0009823)1.64986170
140* Aplasia of the phalanges of the hand (HP:0009802)1.64986170
141* Aplasia involving bones of the extremities (HP:0009825)1.64986170
142Progressive macrocephaly (HP:0004481)1.64609240
143Malignant gastrointestinal tract tumors (HP:0006749)1.63448871
144Gastrointestinal carcinoma (HP:0002672)1.63448871
145Large earlobe (HP:0009748)1.62747641
146Hypopigmentation of the fundus (HP:0007894)1.61967160
147Facial hemangioma (HP:0000329)1.61831234
148Bladder carcinoma (HP:0002862)1.61478836
149Bladder neoplasm (HP:0009725)1.61478836
150Obsessive-compulsive behavior (HP:0000722)1.61253839
151Complete atrioventricular canal defect (HP:0001674)1.57359622
152Astrocytoma (HP:0009592)1.57253019
153Abnormality of the astrocytes (HP:0100707)1.57253019
154Abnormality of the lower motor neuron (HP:0002366)1.56990018
155Overlapping toe (HP:0001845)1.56299368
156Curly hair (HP:0002212)1.56145998
157Broad nasal tip (HP:0000455)1.54888129
158Truncal obesity (HP:0001956)1.54837435
159Deviation of the thumb (HP:0009603)1.54757651
160Absent eyebrow (HP:0002223)1.54370975
161Ankyloglossia (HP:0010296)1.53544212
162Neoplasm of the thyroid gland (HP:0100031)1.53374558
163Absent frontal sinuses (HP:0002688)1.52388015
164Abnormality of the epiphyses of the hand (HP:0005924)1.50826906
165Abnormality of chromosome segregation (HP:0002916)1.49780352
166Abnormal lung lobation (HP:0002101)1.49105158
167Cafe-au-lait spot (HP:0000957)1.48992903
168Urinary bladder sphincter dysfunction (HP:0002839)1.48008999
169Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.46894745
170Cystic hygroma (HP:0000476)1.46873989
171Tubulointerstitial nephritis (HP:0001970)1.45048389
172Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.44448974
173Glioma (HP:0009733)1.44152182
174Tracheomalacia (HP:0002779)1.42866483
175Hepatoblastoma (HP:0002884)1.42324681
176Smooth philtrum (HP:0000319)1.40413878
177Hypospadias (HP:0000047)1.40161298
178Embryonal neoplasm (HP:0002898)1.39976685
179Proximal placement of thumb (HP:0009623)1.39769787
180Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.39157304
181Open mouth (HP:0000194)1.37989573
182Ectopic kidney (HP:0000086)1.37200531
183Bronchomalacia (HP:0002780)1.37179627
184Spastic paraplegia (HP:0001258)1.36750799
185Flat acetabular roof (HP:0003180)1.36431094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL23.78574491
2CASK3.62020094
3LATS13.47630213
4NTRK33.44816481
5MARK13.05823001
6EPHA42.79610988
7CDK122.62937094
8MAP2K72.62656711
9INSRR2.49668423
10MAP3K42.45152534
11MAP3K92.38995516
12TNIK2.32713393
13EEF2K2.15703752
14BRD42.14581895
15SRPK12.01248098
16MAPK131.95195718
17AKT31.92045137
18NTRK21.89602511
19MINK11.76079132
20CSNK1A1L1.74994809
21STK391.72655438
22PRPF4B1.72104851
23PBK1.69668337
24OXSR11.59385160
25MAP3K121.48371483
26PAK61.47596065
27PLK21.47474935
28TSSK61.45554996
29PNCK1.42468506
30KSR21.41129053
31SGK4941.40192688
32SGK2231.40192688
33PHKG11.37940081
34PHKG21.37940081
35PKN21.37911217
36MAP2K41.36582881
37BMPR1B1.35795524
38KSR11.34967426
39TTK1.34563172
40CDC71.34266127
41RPS6KB21.30908440
42DAPK21.30513848
43SGK21.27167012
44CSNK1G11.25278006
45DYRK1A1.24431225
46CDK191.23772281
47CDK51.22769614
48CSNK1G31.21992997
49MET1.20440700
50PDK41.19420467
51PDK31.19420467
52ICK1.18470476
53NEK11.18338291
54RPS6KA41.15439323
55DYRK21.15072806
56PIK3CA1.11773681
57BMPR21.10720624
58CHEK21.08363763
59CAMK2A1.07956303
60CCNB11.05563727
61WNK41.05191501
62EPHA31.04396050
63PDGFRA1.02950064
64TRIM281.00751186
65PDK20.98771317
66CAMK2B0.98515432
67NTRK10.97859299
68RET0.97386280
69MAP4K20.96465898
70PRKD30.95865149
71MAP3K100.94008362
72WEE10.93965995
73GRK50.92382751
74MUSK0.91337939
75BRAF0.90712092
76WNK10.89578731
77PAK30.89504237
78STK30.88087569
79BCR0.86595969
80MST1R0.86341085
81RPS6KB10.86306033
82PTK2B0.85933409
83PRKCG0.85810963
84PKN10.85512323
85FER0.85232959
86FGFR20.84787775
87ATR0.84423516
88TRIB30.84337232
89PINK10.84331271
90ERBB30.84063270
91PRKCE0.82101982
92STK38L0.81688524
93NEK20.81493638
94NME10.81120085
95PLK40.80400140
96RIPK40.79531549
97CAMK1G0.78471333
98RAF10.78433408
99CDK70.78420571
100CSNK1G20.78051636
101ATM0.77300593
102EIF2AK10.77076141
103UHMK10.75889866
104STK380.75743135
105CAMK2D0.75482684
106MAP3K20.75013082
107CAMK1D0.74767282
108WNK30.73290580
109CHEK10.71821680
110MTOR0.70537496
111FGR0.68461905
112CAMKK20.67782791
113LATS20.67770528
114CAMKK10.67360534
115SGK10.67304854
116CDK60.67228123
117FGFR10.67095228
118ERBB40.66296812
119MARK20.64877314
120MAPK120.63487608
121NEK60.62983827
122PLK10.62571187
123MAP3K60.61043377
124DYRK30.60102204
125AURKB0.58832612
126CDK10.57710097
127CAMK40.56204881
128LMTK20.56203165
129SGK30.55793821
130DAPK10.55574030
131MAPKAPK50.55496402
132TIE10.55347543
133MAPK100.54051900
134CDK140.52915654
135CDK180.52912966
136GRK70.52174163
137MELK0.50849506
138NEK90.50464685
139CDK150.50345278
140STK110.49585755
141ADRBK10.49207213
142CDK30.48769871
143CAMK10.47619639
144ARAF0.47493310
145LIMK10.46763882
146ROCK20.46544544
147FRK0.45913786
148EIF2AK20.45452805
149EPHA20.44369108
150CDK20.43611845
151CSNK1D0.43537927
152CAMK2G0.43533637
153YES10.43342944
154CDK11A0.42966100
155AKT20.42760527
156ZAK0.42591916
157MAPK70.41280184
158PRKG10.40756434

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.81436191
2Synaptic vesicle cycle_Homo sapiens_hsa047212.72158443
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61640427
4GABAergic synapse_Homo sapiens_hsa047272.42152986
5Glutamatergic synapse_Homo sapiens_hsa047242.40630704
6Olfactory transduction_Homo sapiens_hsa047402.36802168
7Circadian entrainment_Homo sapiens_hsa047132.34267710
8Morphine addiction_Homo sapiens_hsa050322.21701445
9Long-term potentiation_Homo sapiens_hsa047202.17371715
10Taste transduction_Homo sapiens_hsa047422.08830484
11Amphetamine addiction_Homo sapiens_hsa050312.02104095
12Serotonergic synapse_Homo sapiens_hsa047261.96202959
13Collecting duct acid secretion_Homo sapiens_hsa049661.87598945
14Salivary secretion_Homo sapiens_hsa049701.86757409
15Dopaminergic synapse_Homo sapiens_hsa047281.84871915
16Renin secretion_Homo sapiens_hsa049241.81845730
17Insulin secretion_Homo sapiens_hsa049111.77320375
18Cell cycle_Homo sapiens_hsa041101.69790855
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68271726
20Thyroid cancer_Homo sapiens_hsa052161.67363074
21Long-term depression_Homo sapiens_hsa047301.66440073
22Cholinergic synapse_Homo sapiens_hsa047251.63019421
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61557796
24DNA replication_Homo sapiens_hsa030301.61115438
25Non-homologous end-joining_Homo sapiens_hsa034501.57643580
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55119379
27Calcium signaling pathway_Homo sapiens_hsa040201.54308255
28Axon guidance_Homo sapiens_hsa043601.52622252
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51491077
30Fanconi anemia pathway_Homo sapiens_hsa034601.49194799
31Oxytocin signaling pathway_Homo sapiens_hsa049211.45174583
32Phototransduction_Homo sapiens_hsa047441.45099622
33mRNA surveillance pathway_Homo sapiens_hsa030151.44522202
34RNA transport_Homo sapiens_hsa030131.42683971
35Cardiac muscle contraction_Homo sapiens_hsa042601.41627248
36Cocaine addiction_Homo sapiens_hsa050301.41162746
37Gastric acid secretion_Homo sapiens_hsa049711.37606422
38Hippo signaling pathway_Homo sapiens_hsa043901.37416096
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34137210
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32967751
41Oxidative phosphorylation_Homo sapiens_hsa001901.32367374
42Lysine degradation_Homo sapiens_hsa003101.31916726
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30918393
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30593617
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30383353
46Mismatch repair_Homo sapiens_hsa034301.27704422
47Alcoholism_Homo sapiens_hsa050341.27612561
48Circadian rhythm_Homo sapiens_hsa047101.27110255
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.26609619
50Gap junction_Homo sapiens_hsa045401.24917385
51Adherens junction_Homo sapiens_hsa045201.22084248
52GnRH signaling pathway_Homo sapiens_hsa049121.21005160
53Colorectal cancer_Homo sapiens_hsa052101.18889657
54cAMP signaling pathway_Homo sapiens_hsa040241.18855647
55mTOR signaling pathway_Homo sapiens_hsa041501.18619767
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16795749
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14538241
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.13388536
59TGF-beta signaling pathway_Homo sapiens_hsa043501.12903326
60MicroRNAs in cancer_Homo sapiens_hsa052061.12658731
61Vibrio cholerae infection_Homo sapiens_hsa051101.11583950
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09760213
63Alzheimers disease_Homo sapiens_hsa050101.09676607
64Nucleotide excision repair_Homo sapiens_hsa034201.08606875
65Vascular smooth muscle contraction_Homo sapiens_hsa042701.07956672
66Ether lipid metabolism_Homo sapiens_hsa005651.05407543
67ErbB signaling pathway_Homo sapiens_hsa040121.05087262
68AMPK signaling pathway_Homo sapiens_hsa041521.04955478
69Chronic myeloid leukemia_Homo sapiens_hsa052201.04473468
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04094614
71Non-small cell lung cancer_Homo sapiens_hsa052231.03318480
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02688002
73cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02334311
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99214313
75Melanogenesis_Homo sapiens_hsa049160.98530721
76Basal transcription factors_Homo sapiens_hsa030220.97368599
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96085331
78Ovarian steroidogenesis_Homo sapiens_hsa049130.95181202
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94486078
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93790792
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92597287
82Sphingolipid metabolism_Homo sapiens_hsa006000.91273703
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90778141
84Selenocompound metabolism_Homo sapiens_hsa004500.89836374
85Dilated cardiomyopathy_Homo sapiens_hsa054140.89635108
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89019725
87Base excision repair_Homo sapiens_hsa034100.88483442
88Pancreatic cancer_Homo sapiens_hsa052120.88200137
89Prostate cancer_Homo sapiens_hsa052150.85380702
90Small cell lung cancer_Homo sapiens_hsa052220.84476652
91Dorso-ventral axis formation_Homo sapiens_hsa043200.84105670
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.81934834
93Parkinsons disease_Homo sapiens_hsa050120.81235880
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80961611
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80476713
96Type II diabetes mellitus_Homo sapiens_hsa049300.80244277
97Huntingtons disease_Homo sapiens_hsa050160.79406794
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77907473
99Estrogen signaling pathway_Homo sapiens_hsa049150.77643587
100Ras signaling pathway_Homo sapiens_hsa040140.76329695
101Basal cell carcinoma_Homo sapiens_hsa052170.75242075
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75031376
103Steroid biosynthesis_Homo sapiens_hsa001000.75009043
104Homologous recombination_Homo sapiens_hsa034400.74055010
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73696805
106Glioma_Homo sapiens_hsa052140.72600081
107Choline metabolism in cancer_Homo sapiens_hsa052310.71334664
108One carbon pool by folate_Homo sapiens_hsa006700.69383216
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69382323
110Spliceosome_Homo sapiens_hsa030400.68555632
111Wnt signaling pathway_Homo sapiens_hsa043100.68481063
112MAPK signaling pathway_Homo sapiens_hsa040100.68321767
113Insulin signaling pathway_Homo sapiens_hsa049100.67999451
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67738077
115Focal adhesion_Homo sapiens_hsa045100.66593267
116Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66500949
117Proteoglycans in cancer_Homo sapiens_hsa052050.66107732
118Pancreatic secretion_Homo sapiens_hsa049720.65349016
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65035447
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.64273468
121Arginine biosynthesis_Homo sapiens_hsa002200.64242536
122Fatty acid biosynthesis_Homo sapiens_hsa000610.64138475
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63869829
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.60981993
125ECM-receptor interaction_Homo sapiens_hsa045120.60049565
126Oocyte meiosis_Homo sapiens_hsa041140.59705635
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59391972
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59269266
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58438979
130Renal cell carcinoma_Homo sapiens_hsa052110.56839631
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54269785
132Inositol phosphate metabolism_Homo sapiens_hsa005620.54229410
133VEGF signaling pathway_Homo sapiens_hsa043700.52964969
134Prolactin signaling pathway_Homo sapiens_hsa049170.52158907
135Pathways in cancer_Homo sapiens_hsa052000.51218174
136Mineral absorption_Homo sapiens_hsa049780.50528075
137Hedgehog signaling pathway_Homo sapiens_hsa043400.50273195
138Rheumatoid arthritis_Homo sapiens_hsa053230.49557434
139Thyroid hormone synthesis_Homo sapiens_hsa049180.48965765
140Vitamin B6 metabolism_Homo sapiens_hsa007500.47793317
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.46760165
142Glucagon signaling pathway_Homo sapiens_hsa049220.46377204
143Rap1 signaling pathway_Homo sapiens_hsa040150.45676448
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45559889
145Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45112127
146Melanoma_Homo sapiens_hsa052180.41370994
147Phagosome_Homo sapiens_hsa041450.36731214
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35987920
149Fatty acid elongation_Homo sapiens_hsa000620.33946903
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31956266
151Tight junction_Homo sapiens_hsa045300.31931297
152Butanoate metabolism_Homo sapiens_hsa006500.30379768
153Endometrial cancer_Homo sapiens_hsa052130.30262770

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