LMBR1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)5.68207244
2fusion of sperm to egg plasma membrane (GO:0007342)5.55623317
3sperm-egg recognition (GO:0035036)5.13851225
4cell wall macromolecule catabolic process (GO:0016998)5.04703524
5cell wall macromolecule metabolic process (GO:0044036)5.04703524
6regulation of gamma-delta T cell differentiation (GO:0045586)5.04452745
7cell-cell recognition (GO:0009988)4.92425114
8positive regulation of T cell differentiation in thymus (GO:0033089)4.90574957
9positive regulation of gamma-delta T cell activation (GO:0046645)4.79346412
10binding of sperm to zona pellucida (GO:0007339)4.73840310
11activated T cell proliferation (GO:0050798)4.68751298
12positive thymic T cell selection (GO:0045059)4.66056369
13acrosome assembly (GO:0001675)4.56051491
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.55880273
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.55880273
16regulation of gamma-delta T cell activation (GO:0046643)4.52384769
17multicellular organism reproduction (GO:0032504)4.41432816
18antigen processing and presentation of endogenous antigen (GO:0019883)4.34528299
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.30567903
20synaptonemal complex assembly (GO:0007130)4.28581816
21spermatid development (GO:0007286)4.26619789
22regulation of gonadotropin secretion (GO:0032276)4.21798923
23acrosome reaction (GO:0007340)4.15780715
24synaptonemal complex organization (GO:0070193)4.09891543
25piRNA metabolic process (GO:0034587)4.04561170
26thymic T cell selection (GO:0045061)4.01505478
27reproduction (GO:0000003)3.98988741
28plasma membrane fusion (GO:0045026)3.92020552
29negative regulation of alpha-beta T cell differentiation (GO:0046639)3.88259755
30positive T cell selection (GO:0043368)3.87056407
31negative T cell selection (GO:0043383)3.85320501
32negative thymic T cell selection (GO:0045060)3.77995948
33T cell selection (GO:0045058)3.71375823
34motile cilium assembly (GO:0044458)3.67547186
35cilium or flagellum-dependent cell motility (GO:0001539)3.64704181
36regulation of B cell receptor signaling pathway (GO:0050855)3.62845658
37male meiosis (GO:0007140)3.61216528
38chromosome condensation (GO:0030261)3.53997454
39regulation of interleukin-12 biosynthetic process (GO:0045075)3.48716245
40negative regulation of alpha-beta T cell activation (GO:0046636)3.48451842
41axonemal dynein complex assembly (GO:0070286)3.40931139
42positive regulation of histone deacetylation (GO:0031065)3.36525157
43negative regulation of cell killing (GO:0031342)3.33531658
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.33531658
45DNA packaging (GO:0006323)3.32553766
46negative regulation of inclusion body assembly (GO:0090084)3.31558112
47positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.30728132
48NIK/NF-kappaB signaling (GO:0038061)3.28422942
49nuclear pore complex assembly (GO:0051292)3.25167417
50monoubiquitinated protein deubiquitination (GO:0035520)3.16348209
51mitotic sister chromatid cohesion (GO:0007064)3.09132933
52gene silencing by RNA (GO:0031047)3.09081049
53antigen processing and presentation via MHC class Ib (GO:0002475)3.06576423
54spermatogenesis (GO:0007283)3.03600088
55positive regulation of protein homooligomerization (GO:0032464)3.03575656
56pre-miRNA processing (GO:0031054)3.03531029
57male gamete generation (GO:0048232)3.02240812
58gene silencing (GO:0016458)3.01880518
59negative regulation of lymphocyte mediated immunity (GO:0002707)3.01432702
60tolerance induction (GO:0002507)3.00255912
61RNA destabilization (GO:0050779)2.95341771
62cellular response to interleukin-15 (GO:0071350)2.94747286
63chromatin silencing (GO:0006342)2.90516246
64cellular extravasation (GO:0045123)2.90179859
65interferon-gamma secretion (GO:0072643)2.87245263
66behavioral response to nicotine (GO:0035095)2.86837618
67mannose metabolic process (GO:0006013)2.85737657
68regulation of RNA export from nucleus (GO:0046831)2.85018200
69sex determination (GO:0007530)2.84553425
70negative regulation of histone methylation (GO:0031061)2.84538457
71somite development (GO:0061053)2.83915189
72epithelial cilium movement (GO:0003351)2.83566029
73regulation of chromatin binding (GO:0035561)2.82641221
74pyrimidine nucleobase catabolic process (GO:0006208)2.81860019
75single fertilization (GO:0007338)2.81465703
76gamete generation (GO:0007276)2.78620329
77regulation of cilium movement (GO:0003352)2.78035957
78seminiferous tubule development (GO:0072520)2.77364582
79negative regulation of T cell mediated immunity (GO:0002710)2.77259470
80heterochromatin organization (GO:0070828)2.76930627
81response to muramyl dipeptide (GO:0032495)2.76405639
82negative regulation of T cell differentiation in thymus (GO:0033085)2.76239803
83negative regulation of cAMP-mediated signaling (GO:0043951)2.76170337
84interferon-gamma production (GO:0032609)2.74758897
85nuclear pore organization (GO:0006999)2.73692083
86genitalia morphogenesis (GO:0035112)2.73401629
87regulation of T cell tolerance induction (GO:0002664)2.70884225
88regulation of cholesterol homeostasis (GO:2000188)2.70074761
89intracellular estrogen receptor signaling pathway (GO:0030520)2.69418112
90cellular hyperosmotic response (GO:0071474)2.69369070
91modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68927690
92positive regulation by organism of defense response of other organism involved in symbiotic interact2.68927690
93modulation by symbiont of host immune response (GO:0052553)2.68927690
94positive regulation by symbiont of host defense response (GO:0052509)2.68927690
95modulation by symbiont of host defense response (GO:0052031)2.68927690
96modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68927690
97cytoplasmic mRNA processing body assembly (GO:0033962)2.68303895
98germ cell development (GO:0007281)2.68257354
99regulation of histone H3-K9 methylation (GO:0051570)2.68148427
100positive regulation of CREB transcription factor activity (GO:0032793)2.67370534
101response to interleukin-15 (GO:0070672)2.66943868
102negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66716740
103B cell receptor signaling pathway (GO:0050853)2.66553110
104fertilization (GO:0009566)2.65961480
105histone H3-K4 trimethylation (GO:0080182)2.64905787
106histone H3-K9 demethylation (GO:0033169)2.64880176
107cellular process involved in reproduction in multicellular organism (GO:0022412)2.63964982
108organic cation transport (GO:0015695)2.61112403
109leukocyte aggregation (GO:0070486)2.60839901
110morphogenesis of an endothelium (GO:0003159)2.60520538
111endothelial tube morphogenesis (GO:0061154)2.60520538
112positive regulation of tolerance induction (GO:0002645)2.59201885
113histone H3-K9 modification (GO:0061647)2.58726103
114negative regulation of gene expression, epigenetic (GO:0045814)2.56701433
115chromosome organization involved in meiosis (GO:0070192)2.56425630
116positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.56287569
117negative regulation of cytokine biosynthetic process (GO:0042036)2.55421414
118histone H3-K36 demethylation (GO:0070544)2.55270321
119positive regulation of alpha-beta T cell differentiation (GO:0046638)2.54317728
120T cell costimulation (GO:0031295)2.52603720
121negative regulation of leukocyte mediated immunity (GO:0002704)2.52442274
122sexual reproduction (GO:0019953)2.50434476
123NLS-bearing protein import into nucleus (GO:0006607)2.50391981
124regulation of inclusion body assembly (GO:0090083)2.49617072
125regulation of T cell mediated cytotoxicity (GO:0001914)2.49357339
126JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.49205130
127negative regulation of T-helper cell differentiation (GO:0045623)2.49086933
128negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.49086933
129regulation of B cell differentiation (GO:0045577)2.48416192
130T cell receptor signaling pathway (GO:0050852)2.46791041
131meiotic nuclear division (GO:0007126)2.46323652
132male meiosis I (GO:0007141)2.44476256
133lymphocyte costimulation (GO:0031294)2.44004105
134regulation of Rab GTPase activity (GO:0032313)2.43974118
135positive regulation of Rab GTPase activity (GO:0032851)2.43974118
136positive regulation of interleukin-2 production (GO:0032743)2.41889779
137regulation of alpha-beta T cell proliferation (GO:0046640)2.41472553
138regulation of response to interferon-gamma (GO:0060330)2.41214795
139Arp2/3 complex-mediated actin nucleation (GO:0034314)2.41142678
140histone H3-K9 methylation (GO:0051567)2.41111909
141RNA stabilization (GO:0043489)2.41083839
142mRNA stabilization (GO:0048255)2.41083839
143T cell migration (GO:0072678)2.41053930
144macrophage activation involved in immune response (GO:0002281)2.40969516
145negative regulation of erythrocyte differentiation (GO:0045647)2.40571861
146positive regulation of B cell differentiation (GO:0045579)2.40568113
147negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.40399245
148negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.39989965
149pore complex assembly (GO:0046931)2.39947950
150cellular response to exogenous dsRNA (GO:0071360)2.39796699
151positive regulation of T cell mediated cytotoxicity (GO:0001916)2.39454396
152regulation of alpha-beta T cell differentiation (GO:0046637)2.39066413
153phosphatidylethanolamine biosynthetic process (GO:0006646)2.36493241
154regulation of regulatory T cell differentiation (GO:0045589)2.36465881
155germinal center formation (GO:0002467)2.36420209
156negative regulation of T cell differentiation (GO:0045581)2.35565111
157positive regulation of granulocyte differentiation (GO:0030854)2.34890194
158negative regulation of interleukin-12 production (GO:0032695)2.32009105
159positive regulation of protein deacetylation (GO:0090312)2.31909959
160negative regulation of interleukin-1 production (GO:0032692)2.30646018
161regulation of alpha-beta T cell activation (GO:0046634)2.30096700
162negative regulation of interleukin-1 beta production (GO:0032691)2.29417819
163regulation of natural killer cell mediated immunity (GO:0002715)2.29357737
164regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.29357737
165positive regulation of calcium-mediated signaling (GO:0050850)2.28341347
166mast cell activation (GO:0045576)2.26364537
167establishment of protein localization to Golgi (GO:0072600)2.25183598
168oocyte development (GO:0048599)2.23002287
169negative regulation of adaptive immune response (GO:0002820)2.22356243
170protein polyglutamylation (GO:0018095)2.21231101
171antigen receptor-mediated signaling pathway (GO:0050851)2.19826064
172regulation of leukocyte mediated cytotoxicity (GO:0001910)2.19749330
173regulation of dendritic cell antigen processing and presentation (GO:0002604)2.19639037
174regulation of granulocyte differentiation (GO:0030852)2.19193405
175head development (GO:0060322)2.18747090
176phosphatidylethanolamine metabolic process (GO:0046337)2.18254109
177regulation of isotype switching to IgG isotypes (GO:0048302)2.18037064

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.99409460
2EZH2_22144423_ChIP-Seq_EOC_Human3.75877625
3MYC_22102868_ChIP-Seq_BL_Human3.56537717
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.93631957
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.92026859
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.71063874
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64505585
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.60649503
9TCF7_22412390_ChIP-Seq_EML_Mouse2.57778751
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.54873140
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.45717048
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.38316418
13* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.35249078
14VDR_21846776_ChIP-Seq_THP-1_Human2.31605339
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.27277302
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.26200709
17MAF_26560356_Chip-Seq_TH1_Human2.26122603
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.24881944
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24168757
20UTX_26944678_Chip-Seq_JUKART_Human2.23482029
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19624460
22DROSHA_22980978_ChIP-Seq_HELA_Human2.16303049
23KDM2B_26808549_Chip-Seq_DND41_Human2.10855111
24MYB_26560356_Chip-Seq_TH1_Human2.03496944
25MYB_26560356_Chip-Seq_TH2_Human1.99213670
26* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96608776
27* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.89715903
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87987280
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83792139
30RUNX_20019798_ChIP-Seq_JUKART_Human1.75117748
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72250903
32MAF_26560356_Chip-Seq_TH2_Human1.70961284
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69519001
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68787666
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67287913
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66138800
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65204798
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.64141790
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62778284
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62174205
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61216971
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56408362
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52387099
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.52354421
45ZNF274_21170338_ChIP-Seq_K562_Hela1.50569900
46* RXR_22158963_ChIP-Seq_LIVER_Mouse1.49769343
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.48614895
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47256336
49* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47183279
50REST_21632747_ChIP-Seq_MESCs_Mouse1.45342682
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44224660
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41241148
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.40213677
54FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40044628
55E2F7_22180533_ChIP-Seq_HELA_Human1.38420696
56* LXR_22158963_ChIP-Seq_LIVER_Mouse1.35745311
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34655383
58* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33589705
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32586893
60VDR_24763502_ChIP-Seq_THP-1_Human1.30056254
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29179210
62* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28821772
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.28397768
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28208985
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28109959
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.26673968
67* GATA3_27048872_Chip-Seq_THYMUS_Human1.26612585
68LXR_22292898_ChIP-Seq_THP-1_Human1.26439325
69SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25420323
70* NCOR1_26117541_ChIP-Seq_K562_Human1.24987489
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21728167
72BCOR_27268052_Chip-Seq_Bcells_Human1.21077244
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.20270286
74P68_20966046_ChIP-Seq_HELA_Human1.18036279
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16894997
76ZNF263_19887448_ChIP-Seq_K562_Human1.15338511
77VDR_24787735_ChIP-Seq_THP-1_Human1.14496284
78CIITA_25753668_ChIP-Seq_RAJI_Human1.14182766
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.14097221
80OCT4_19829295_ChIP-Seq_ESCs_Human1.13583306
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13048415
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12410500
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12067130
84BCL6_27268052_Chip-Seq_Bcells_Human1.12000432
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11720739
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11282573
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10128648
88RUNX1_27514584_Chip-Seq_MCF-7_Human1.09640484
89PHF8_20622854_ChIP-Seq_HELA_Human1.09071087
90JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08809765
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.08709972
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08398199
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08063092
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07417042
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06261743
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.06128227
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05079910
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05059433
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04882389
100ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04502626
101SCL_19346495_ChIP-Seq_HPC-7_Human1.04040378
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03765578
103ERA_21632823_ChIP-Seq_H3396_Human1.03446551
104EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03286890
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03202039
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02504836
107ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02252995
108RAC3_21632823_ChIP-Seq_H3396_Human1.01860863
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01384004
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01156940
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01017066
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01017066
113CTCF_27219007_Chip-Seq_Bcells_Human1.00925518
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00636252
115* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99699853
116SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99007544
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98466628
118SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97751738
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97374755
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97170871
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95635696
122RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95256011
123P300_27268052_Chip-Seq_Bcells_Human0.94885666
124EZH2_27304074_Chip-Seq_ESCs_Mouse0.94287949
125FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94014544
126* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93322068
127WDR5_24793694_ChIP-Seq_LNCAP_Human0.93067678
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93042006
129CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92842536
130IRF8_21731497_ChIP-ChIP_J774_Mouse0.92823158
131* SA1_27219007_Chip-Seq_ERYTHROID_Human0.92525642
132SPI1_23127762_ChIP-Seq_K562_Human0.92179828
133RACK7_27058665_Chip-Seq_MCF-7_Human0.92176282
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92073353
135KDM2B_26808549_Chip-Seq_K562_Human0.91455394
136AR_21572438_ChIP-Seq_LNCaP_Human0.91077474
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90862122
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89841183
139CTCF_26484167_Chip-Seq_Bcells_Mouse0.89683541
140E2F1_20622854_ChIP-Seq_HELA_Human0.89538797
141CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89352745
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88948579
143SMC4_20622854_ChIP-Seq_HELA_Human0.88804679
144* GATA3_26560356_Chip-Seq_TH2_Human0.88690017
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88387891
146FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88375962
147CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88024947
148TET1_21451524_ChIP-Seq_MESCs_Mouse0.87335974
149RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87309834
150KDM5A_27292631_Chip-Seq_BREAST_Human0.87298660
151SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87098449
152SMRT_27268052_Chip-Seq_Bcells_Human0.84845373
153KLF4_19829295_ChIP-Seq_ESCs_Human0.84842831
154GATA1_19941826_ChIP-Seq_K562_Human0.84154077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.17887762
2MP0003283_abnormal_digestive_organ4.51047598
3MP0003724_increased_susceptibility_to3.20894579
4MP0002822_catalepsy3.05479237
5MP0003763_abnormal_thymus_physiology2.70939627
6MP0008995_early_reproductive_senescence2.52743342
7MP0000685_abnormal_immune_system2.43580416
8MP0005360_urolithiasis2.31949284
9MP0001800_abnormal_humoral_immune2.20376247
10MP0001929_abnormal_gametogenesis2.11931542
11MP0001986_abnormal_taste_sensitivity2.08871996
12MP0003300_gastrointestinal_ulcer2.05778437
13MP0009278_abnormal_bone_marrow2.02132526
14MP0003303_peritoneal_inflammation1.96212179
15MP0003698_abnormal_male_reproductive1.95752626
16MP0003705_abnormal_hypodermis_morpholog1.95634038
17MP0001790_abnormal_immune_system1.90468290
18MP0005387_immune_system_phenotype1.90468290
19MP0004947_skin_inflammation1.88399877
20MP0010352_gastrointestinal_tract_polyps1.88393639
21MP0002166_altered_tumor_susceptibility1.85822813
22MP0005076_abnormal_cell_differentiation1.80584562
23MP0001835_abnormal_antigen_presentation1.78980537
24MP0005423_abnormal_somatic_nervous1.78438780
25MP0002398_abnormal_bone_marrow1.78430665
26MP0005670_abnormal_white_adipose1.75781845
27MP0002138_abnormal_hepatobiliary_system1.74232559
28MP0001873_stomach_inflammation1.73476825
29MP0008877_abnormal_DNA_methylation1.72076026
30MP0005365_abnormal_bile_salt1.71001262
31MP0008961_abnormal_basal_metabolism1.69005022
32MP0000703_abnormal_thymus_morphology1.66855309
33MP0004808_abnormal_hematopoietic_stem1.66096781
34MP0002933_joint_inflammation1.65402702
35MP0002452_abnormal_antigen_presenting1.62455124
36MP0002653_abnormal_ependyma_morphology1.61766930
37MP0002139_abnormal_hepatobiliary_system1.61522899
38MP0003436_decreased_susceptibility_to1.61231637
39MP0002723_abnormal_immune_serum1.60188778
40MP0003195_calcinosis1.60034856
41MP0003252_abnormal_bile_duct1.55589623
42MP0009840_abnormal_foam_cell1.55418673
43MP0005671_abnormal_response_to1.53100708
44MP0002420_abnormal_adaptive_immunity1.52693070
45MP0003172_abnormal_lysosome_physiology1.52582469
46MP0001819_abnormal_immune_cell1.50592117
47MP0000716_abnormal_immune_system1.49626951
48MP0002405_respiratory_system_inflammati1.48311366
49MP0001501_abnormal_sleep_pattern1.47706513
50MP0000689_abnormal_spleen_morphology1.45472640
51MP0002722_abnormal_immune_system1.45344249
52MP0001968_abnormal_touch/_nociception1.43083365
53MP0005377_hearing/vestibular/ear_phenot1.41280690
54MP0003878_abnormal_ear_physiology1.41280690
55MP0005167_abnormal_blood-brain_barrier1.37741046
56MP0005000_abnormal_immune_tolerance1.35195853
57MP0003011_delayed_dark_adaptation1.33929423
58MP0004510_myositis1.31200251
59MP0010155_abnormal_intestine_physiology1.31111621
60MP0002006_tumorigenesis1.29024878
61MP0000609_abnormal_liver_physiology1.27957949
62MP0002429_abnormal_blood_cell1.27126709
63MP0002210_abnormal_sex_determination1.25267086
64MP0002396_abnormal_hematopoietic_system1.24343171
65MP0010307_abnormal_tumor_latency1.24268609
66MP0001545_abnormal_hematopoietic_system1.24211148
67MP0005397_hematopoietic_system_phenotyp1.24211148
68MP0009333_abnormal_splenocyte_physiolog1.23795084
69MP0001533_abnormal_skeleton_physiology1.22512174
70MP0005310_abnormal_salivary_gland1.19226317
71MP0003787_abnormal_imprinting1.18470501
72MP0003077_abnormal_cell_cycle1.16825393
73MP0009764_decreased_sensitivity_to1.16342513
74MP0003866_abnormal_defecation1.15737230
75MP0003191_abnormal_cellular_cholesterol1.14826119
76MP0002161_abnormal_fertility/fecundity1.14336729
77MP0001145_abnormal_male_reproductive1.14099231
78MP0004742_abnormal_vestibular_system1.13617839
79MP0003183_abnormal_peptide_metabolism1.13256767
80MP0001730_embryonic_growth_arrest1.13130240
81MP0004145_abnormal_muscle_electrophysio1.12865242
82MP0001849_ear_inflammation1.12456574
83MP0003111_abnormal_nucleus_morphology1.12333488
84MP0004142_abnormal_muscle_tone1.11561714
85MP0003693_abnormal_embryo_hatching1.11258177
86MP0005025_abnormal_response_to1.08360025
87MP0001502_abnormal_circadian_rhythm1.08297038
88MP0001851_eye_inflammation1.08290187
89MP0008057_abnormal_DNA_replication1.07886067
90MP0002254_reproductive_system_inflammat1.07214606
91MP0000465_gastrointestinal_hemorrhage1.06856807
92MP0002148_abnormal_hypersensitivity_rea1.06053997
93MP0000569_abnormal_digit_pigmentation1.05970105
94MP0009745_abnormal_behavioral_response1.05953810
95MP0001845_abnormal_inflammatory_respons1.05340607
96MP0003045_fibrosis1.04970463
97MP0003828_pulmonary_edema1.04946837
98MP0005464_abnormal_platelet_physiology1.04605390
99MP0003635_abnormal_synaptic_transmissio1.03801204
100MP0010234_abnormal_vibrissa_follicle1.02365042
101MP0004130_abnormal_muscle_cell1.00789410
102MP0002928_abnormal_bile_duct1.00589075
103MP0006276_abnormal_autonomic_nervous1.00173610
104MP0005023_abnormal_wound_healing0.99755231
105MP0002733_abnormal_thermal_nociception0.96207230
106MP0000653_abnormal_sex_gland0.95930966
107MP0004883_abnormal_blood_vessel0.95868931
108MP0006082_CNS_inflammation0.92062260
109MP0002063_abnormal_learning/memory/cond0.91441509
110MP0001853_heart_inflammation0.91246236
111MP0002019_abnormal_tumor_incidence0.90682978
112MP0005085_abnormal_gallbladder_physiolo0.90580763
113MP0000733_abnormal_muscle_development0.89189284
114MP0002088_abnormal_embryonic_growth/wei0.87721802
115MP0002572_abnormal_emotion/affect_behav0.87032918
116MP0000350_abnormal_cell_proliferation0.86997606
117MP0003984_embryonic_growth_retardation0.86924683
118MP0004859_abnormal_synaptic_plasticity0.86453599
119MP0005380_embryogenesis_phenotype0.85761497
120MP0001672_abnormal_embryogenesis/_devel0.85761497
121MP0003566_abnormal_cell_adhesion0.83875415
122MP0010094_abnormal_chromosome_stability0.83246674
123MP0005551_abnormal_eye_electrophysiolog0.81570282
124MP0002064_seizures0.80950445
125MP0010329_abnormal_lipoprotein_level0.80714201
126MP0008469_abnormal_protein_level0.80547298
127MP0002419_abnormal_innate_immunity0.80344221
128MP0002086_abnormal_extraembryonic_tissu0.80187119
129MP0002272_abnormal_nervous_system0.79985961
130MP0001348_abnormal_lacrimal_gland0.78868127
131MP0003448_altered_tumor_morphology0.78729583
132MP0000598_abnormal_liver_morphology0.78602830
133MP0003453_abnormal_keratinocyte_physiol0.78208945
134MP0001970_abnormal_pain_threshold0.77084056
135MP0002136_abnormal_kidney_physiology0.77062009
136MP0001486_abnormal_startle_reflex0.76643373
137MP0008260_abnormal_autophagy0.76411542
138MP0005666_abnormal_adipose_tissue0.76348839
139MP0003646_muscle_fatigue0.76332298
140MP0004858_abnormal_nervous_system0.76225799
141MP0002132_abnormal_respiratory_system0.74918618
142MP0009785_altered_susceptibility_to0.73960519
143MP0004381_abnormal_hair_follicle0.73691852
144MP0004197_abnormal_fetal_growth/weight/0.73245194
145MP0008875_abnormal_xenobiotic_pharmacok0.72824681
146MP0008058_abnormal_DNA_repair0.72202515
147MP0001440_abnormal_grooming_behavior0.72017967
148MP0008007_abnormal_cellular_replicative0.71900831
149MP0002557_abnormal_social/conspecific_i0.71392971
150MP0002735_abnormal_chemical_nociception0.70850265
151MP0003091_abnormal_cell_migration0.70689534
152MP0002998_abnormal_bone_remodeling0.70535724
153MP0002067_abnormal_sensory_capabilities0.69349801
154MP0005386_behavior/neurological_phenoty0.69183563
155MP0004924_abnormal_behavior0.69183563
156MP0003879_abnormal_hair_cell0.68829728
157MP0005390_skeleton_phenotype0.68712649

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)6.17197631
2Abnormality of the nasal mucosa (HP:0000433)5.19852980
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.81503877
4Recurrent bronchitis (HP:0002837)4.76080103
5Bronchitis (HP:0012387)4.12617406
6Absent/shortened dynein arms (HP:0200106)4.02316580
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.02316580
8Elevated erythrocyte sedimentation rate (HP:0003565)3.99253163
9Myositis (HP:0100614)3.69640676
10Abnormality of the fingertips (HP:0001211)3.69522581
11Recurrent sinusitis (HP:0011108)3.63249902
12Recurrent otitis media (HP:0000403)3.61159769
13Stomatitis (HP:0010280)3.39468781
14Heterotopia (HP:0002282)3.23883438
15Infertility (HP:0000789)3.22776872
16T lymphocytopenia (HP:0005403)3.17584541
17Chronic bronchitis (HP:0004469)3.17423361
18Stomach cancer (HP:0012126)3.07476006
19Retrobulbar optic neuritis (HP:0100654)3.02986172
20Optic neuritis (HP:0100653)3.02986172
21Abnormality of T cell number (HP:0011839)3.01763273
22Male infertility (HP:0003251)2.95514514
23Flared iliac wings (HP:0002869)2.90338831
24Recurrent bacterial skin infections (HP:0005406)2.87175576
25Bronchiectasis (HP:0002110)2.85440215
26Orchitis (HP:0100796)2.80977765
27Recurrent viral infections (HP:0004429)2.79255686
28Gastrointestinal infarctions (HP:0005244)2.78546195
29Colitis (HP:0002583)2.78230635
30Hypoplastic iliac wings (HP:0002866)2.76325271
31Genetic anticipation (HP:0003743)2.71695880
32Gonadotropin excess (HP:0000837)2.71501407
33Abnormality of male internal genitalia (HP:0000022)2.63960419
34Recurrent abscess formation (HP:0002722)2.62791064
35Abnormality of the 1st metacarpal (HP:0010009)2.62200817
36Aplasia/Hypoplasia of the tibia (HP:0005772)2.61117218
37Gonadal dysgenesis (HP:0000133)2.60872771
38Progressive cerebellar ataxia (HP:0002073)2.60484842
39Mediastinal lymphadenopathy (HP:0100721)2.60483300
40Rhinitis (HP:0012384)2.59272042
41Pustule (HP:0200039)2.59236777
42Chronic otitis media (HP:0000389)2.58253971
43Autoimmune thrombocytopenia (HP:0001973)2.58185796
44Cerebral aneurysm (HP:0004944)2.55956233
45Abnormal respiratory motile cilium physiology (HP:0012261)2.53289651
46Abnormality of the phalanges of the hallux (HP:0010057)2.53210263
47Recurrent fungal infections (HP:0002841)2.51935071
48Hemoptysis (HP:0002105)2.46562625
49Inflammation of the large intestine (HP:0002037)2.45592783
50Gastrointestinal inflammation (HP:0004386)2.45148435
51Spontaneous hematomas (HP:0007420)2.44294035
52Hyperacusis (HP:0010780)2.44280166
53Meningitis (HP:0001287)2.41050230
54Panhypogammaglobulinemia (HP:0003139)2.40915742
55Short tibia (HP:0005736)2.36886048
56Abnormality of macrophages (HP:0004311)2.36617054
57Myocardial infarction (HP:0001658)2.36416899
58Verrucae (HP:0200043)2.35036863
59Papilloma (HP:0012740)2.35036863
60Combined immunodeficiency (HP:0005387)2.34893651
61Attenuation of retinal blood vessels (HP:0007843)2.34443564
62Abnormal respiratory motile cilium morphology (HP:0005938)2.34022647
63Abnormal respiratory epithelium morphology (HP:0012253)2.34022647
64Abnormality of T cells (HP:0002843)2.32826016
65Encephalitis (HP:0002383)2.31627172
66Short phalanx of the thumb (HP:0009660)2.30027587
67Abnormality of the lower motor neuron (HP:0002366)2.29586974
68Leukocytosis (HP:0001974)2.28583847
69Short femoral neck (HP:0100864)2.27466257
70Keratoconjunctivitis (HP:0001096)2.27108899
71Vasculitis (HP:0002633)2.26960985
72Vertebral arch anomaly (HP:0008438)2.26526046
73Chest pain (HP:0100749)2.25666274
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.25454109
75Broad palm (HP:0001169)2.23693314
76Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.23405517
77Keratoconjunctivitis sicca (HP:0001097)2.23024709
78Abnormality of the proximal phalanges of the hand (HP:0009834)2.15676774
79Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.13919380
80Abnormality of femoral epiphyses (HP:0006499)2.13919380
81Pulmonary infiltrates (HP:0002113)2.12609644
82Pendular nystagmus (HP:0012043)2.12447688
83Granulocytopenia (HP:0001913)2.11457419
84Abnormality of cells of the lymphoid lineage (HP:0012140)2.09607074
85Abnormality of eosinophils (HP:0001879)2.08221213
86Agammaglobulinemia (HP:0004432)2.08170720
87Recurrent skin infections (HP:0001581)2.08081022
88Impulsivity (HP:0100710)2.07688177
89Lymphopenia (HP:0001888)2.07001507
90Fatigue (HP:0012378)2.06910690
91Emphysema (HP:0002097)2.04578070
92Hemiplegia (HP:0002301)2.04486936
93Severe combined immunodeficiency (HP:0004430)2.04053004
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02585777
95Aortic aneurysm (HP:0004942)2.02534065
96Abnormal rod and cone electroretinograms (HP:0008323)2.02517100
97Hypochromic anemia (HP:0001931)2.02397508
98Basal cell carcinoma (HP:0002671)2.01078547
99Abnormality of the femoral head (HP:0003368)1.99835890
100Chronic hepatic failure (HP:0100626)1.97879008
101Recurrent gram-negative bacterial infections (HP:0005420)1.97764471
102Abnormality of the aortic arch (HP:0012303)1.97591169
103Increased IgE level (HP:0003212)1.95929348
104Cupped ribs (HP:0000887)1.95125534
105Chronic sinusitis (HP:0011109)1.94739093
106Congenital stationary night blindness (HP:0007642)1.93972664
107Abnormality of the epiphysis of the femoral head (HP:0010574)1.93605752
108Chronic obstructive pulmonary disease (HP:0006510)1.93515581
109Obstructive lung disease (HP:0006536)1.93515581
110IgM deficiency (HP:0002850)1.93419908
111Hemorrhage of the eye (HP:0011885)1.92471527
112Renovascular hypertension (HP:0100817)1.91694361
113Anal stenosis (HP:0002025)1.91332816
114Papilledema (HP:0001085)1.91152506
115Hyperventilation (HP:0002883)1.90996141
116Deep venous thrombosis (HP:0002625)1.90926031
117Gingivitis (HP:0000230)1.90270298
118Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89296618
119Prolonged bleeding time (HP:0003010)1.88448156
120Congenital sensorineural hearing impairment (HP:0008527)1.87628395
121Abnormality of B cell number (HP:0010975)1.85016508
122B lymphocytopenia (HP:0010976)1.85016508
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84707630
124Bicuspid aortic valve (HP:0001647)1.83372148
125Hand muscle atrophy (HP:0009130)1.82822394
126Severe visual impairment (HP:0001141)1.81826542
127Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81543704
128Short 4th metacarpal (HP:0010044)1.81543704
129Agitation (HP:0000713)1.80368712
130Neoplasm of the tracheobronchial system (HP:0100552)1.80331036
131Alveolar cell carcinoma (HP:0006519)1.80110107
132Pancreatic cysts (HP:0001737)1.79874842
133Eczematoid dermatitis (HP:0000976)1.78000784
134Thoracolumbar scoliosis (HP:0002944)1.76781903
135Pulmonary embolism (HP:0002204)1.76037137
136Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.75335764
137Elfin facies (HP:0004428)1.74572475
138Abnormal sex determination (HP:0012244)1.73704223
139Sex reversal (HP:0012245)1.73704223
140Polycythemia (HP:0001901)1.73528738
141Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73513323
142Ulnar bowing (HP:0003031)1.70904149
143Prominent nose (HP:0000448)1.70051530
144Nephronophthisis (HP:0000090)1.69624158
145Postural instability (HP:0002172)1.69443874
146Abnormality of the 4th metacarpal (HP:0010012)1.69274493
147Retinal dysplasia (HP:0007973)1.68922504
148Chronic diarrhea (HP:0002028)1.68685468
149Increased CSF protein (HP:0002922)1.67363253
150Cellulitis (HP:0100658)1.66590642
151Thyroiditis (HP:0100646)1.64230963
152Eosinophilia (HP:0001880)1.61166010
153Gastrointestinal stroma tumor (HP:0100723)1.59842321
154Bony spicule pigmentary retinopathy (HP:0007737)1.59613108
155Abnormal spermatogenesis (HP:0008669)1.59192138
156Recurrent cutaneous fungal infections (HP:0011370)1.58150067
157Chronic mucocutaneous candidiasis (HP:0002728)1.58150067
158Mitral valve prolapse (HP:0001634)1.57970850
159Increased density of long bones (HP:0006392)1.56668877
160Hypercholesterolemia (HP:0003124)1.55651926
161Dysmetric saccades (HP:0000641)1.55592566
162Ependymoma (HP:0002888)1.55216023
163Abnormality of T cell physiology (HP:0011840)1.54878962
164Hepatitis (HP:0012115)1.54872005
165Distal upper limb amyotrophy (HP:0007149)1.54822584
166Upper limb amyotrophy (HP:0009129)1.54822584
167High pitched voice (HP:0001620)1.51983980
168Periodontitis (HP:0000704)1.50711865
169Flat acetabular roof (HP:0003180)1.49621176
170Joint swelling (HP:0001386)1.49032158
171Arterial thrombosis (HP:0004420)1.48816294
172Amyotrophic lateral sclerosis (HP:0007354)1.48216520
173IgG deficiency (HP:0004315)1.47079417
174Pigmentary retinal degeneration (HP:0001146)1.46899515
175Aneurysm (HP:0002617)1.46433424
176Flattened epiphyses (HP:0003071)1.46327656
177Hematochezia (HP:0002573)1.45611869

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.16133844
2MAP3K103.53505867
3EEF2K3.14993580
4PDK42.82722895
5PDK32.82722895
6CDK122.78074737
7ICK2.68743852
8FGFR42.58663160
9TESK12.36341790
10NEK22.29976018
11TRIB32.24560008
12RIPK42.10207538
13ERN12.08444164
14PRPF4B2.07073226
15STK102.05961956
16FES2.05428348
17GRK62.01878265
18TNK21.91437582
19PKN21.89799093
20TYK21.88410049
21FRK1.74439342
22ZAP701.66459248
23PRKD31.63288038
24PDK21.55533227
25JAK31.53418186
26TXK1.53401064
27ITK1.48211279
28EPHB11.44080703
29SIK21.38104174
30IRAK41.37896101
31MAP4K21.37124613
32PTK61.31327255
33DYRK1B1.30214182
34FGFR31.29577058
35JAK11.29323114
36ADRBK21.26429210
37TYRO31.24771506
38SIK11.24568389
39MAP3K41.23747951
40MAP3K111.23711383
41TTN1.20964315
42RIPK11.14420040
43MTOR1.14219293
44MARK31.12460234
45CSK1.11533415
46MAPK131.11438153
47MAPK151.08604111
48MARK11.07348568
49NTRK21.03959639
50BRD41.03872360
51STK380.99808232
52STK30.98943493
53MAP3K60.97116906
54PIM10.96743105
55LRRK20.96136705
56CHUK0.96093994
57RPS6KA20.95969235
58INSRR0.95326177
59MAP3K140.94040547
60RPS6KA40.92974601
61SIK30.90997605
62CDK40.90233677
63SGK4940.90090914
64SGK2230.90090914
65MAP2K40.90081987
66HCK0.90079451
67CAMKK10.89771480
68LATS10.89433287
69RPS6KA60.88963619
70LYN0.88872809
71SGK20.88426464
72DAPK20.86294857
73MAP2K20.86264531
74MAP2K30.86225740
75TBK10.85701335
76KIT0.85451260
77MAP3K70.84164074
78TAOK10.84012276
79CSF1R0.83003025
80RPS6KC10.82263016
81RPS6KL10.82263016
82BTK0.82233660
83IKBKE0.81266683
84MAPK120.80567223
85MAPK70.79330439
86CAMK1G0.79029102
87LCK0.78136210
88TEC0.77022857
89AKT30.76874510
90PDGFRB0.76567365
91CAMKK20.76290083
92CAMK40.76101326
93CDK60.75566800
94PDK10.73477554
95IKBKB0.71014429
96PIK3CG0.69920185
97MAP3K130.69858405
98TIE10.68991988
99CAMK1D0.68512208
100CDC42BPA0.67974124
101JAK20.66579540
102TGFBR20.66559668
103HIPK20.65263152
104NTRK30.64622929
105FLT30.64590118
106MARK20.64203829
107MAP2K70.63619080
108PRKAA20.62365682
109ALK0.61818571
110NLK0.61773239
111CHEK10.61730449
112TESK20.61211316
113SYK0.60636041
114STK110.59931541
115PINK10.59153924
116MAP2K60.58747001
117RPS6KB20.57775257
118PDGFRA0.57431552
119GRK10.57384042
120PAK30.56651275
121FGFR20.55937989
122PTK2B0.55875745
123MAP3K80.55293634
124MAP3K30.53800493
125PRKCZ0.53251423
126DYRK20.52648141
127STK40.52612799
128PRKCH0.52574917
129EPHA30.51585528
130DYRK1A0.50874232
131CDK90.49500024
132PAK40.47812454
133PRKD20.47608101
134WNK30.47549379
135MELK0.47432458
136BMPR1B0.45209169
137ATR0.45102197
138DYRK30.44700466
139MAPK110.44099446
140RPS6KA10.42367584
141PASK0.42211559
142PTK20.41490077
143PAK20.39458098
144PRKAA10.38670949
145TAOK30.38260740
146MAPKAPK30.38197246
147SGK30.34604187
148PRKCQ0.33343095
149RET0.32396854
150FGFR10.32334011
151BLK0.31844502
152PDPK10.31316263
153ATM0.31016870

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.34978685
2B cell receptor signaling pathway_Homo sapiens_hsa046622.31055449
3T cell receptor signaling pathway_Homo sapiens_hsa046602.25152922
4Graft-versus-host disease_Homo sapiens_hsa053322.25137445
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01170562
6Allograft rejection_Homo sapiens_hsa053302.01066359
7Autoimmune thyroid disease_Homo sapiens_hsa053201.96109103
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.94050009
9Lysine degradation_Homo sapiens_hsa003101.93860066
10Antigen processing and presentation_Homo sapiens_hsa046121.87734145
11Type I diabetes mellitus_Homo sapiens_hsa049401.59590307
12Osteoclast differentiation_Homo sapiens_hsa043801.59448068
13Measles_Homo sapiens_hsa051621.58601510
14Selenocompound metabolism_Homo sapiens_hsa004501.51089421
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44746636
16Acute myeloid leukemia_Homo sapiens_hsa052211.44227209
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.39262306
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.38187610
19Other glycan degradation_Homo sapiens_hsa005111.33343729
20Insulin resistance_Homo sapiens_hsa049311.30855417
21Chronic myeloid leukemia_Homo sapiens_hsa052201.30087987
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28370138
23Herpes simplex infection_Homo sapiens_hsa051681.27985075
24Toxoplasmosis_Homo sapiens_hsa051451.26356710
25Nicotine addiction_Homo sapiens_hsa050331.23426076
26Glycerolipid metabolism_Homo sapiens_hsa005611.20995774
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18901087
28mTOR signaling pathway_Homo sapiens_hsa041501.18871267
29Pentose phosphate pathway_Homo sapiens_hsa000301.18617071
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17818855
31Ovarian steroidogenesis_Homo sapiens_hsa049131.16498224
32Regulation of autophagy_Homo sapiens_hsa041401.13915688
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13074874
34Fat digestion and absorption_Homo sapiens_hsa049751.12401161
35Morphine addiction_Homo sapiens_hsa050321.12216894
36Linoleic acid metabolism_Homo sapiens_hsa005911.12012208
37Tuberculosis_Homo sapiens_hsa051521.09734477
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09568597
39mRNA surveillance pathway_Homo sapiens_hsa030151.09091579
40ABC transporters_Homo sapiens_hsa020101.08796144
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.08626696
42Dorso-ventral axis formation_Homo sapiens_hsa043201.08365565
43Asthma_Homo sapiens_hsa053101.08208080
44PPAR signaling pathway_Homo sapiens_hsa033201.07705096
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07068707
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06282786
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06121024
48Caffeine metabolism_Homo sapiens_hsa002321.05426283
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.04899367
50Glucagon signaling pathway_Homo sapiens_hsa049221.04821244
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04038271
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02425826
53Fatty acid biosynthesis_Homo sapiens_hsa000611.02309567
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02070808
55Notch signaling pathway_Homo sapiens_hsa043301.01380606
56Leishmaniasis_Homo sapiens_hsa051401.01141446
57Influenza A_Homo sapiens_hsa051640.99177202
58Choline metabolism in cancer_Homo sapiens_hsa052310.97545533
59Viral carcinogenesis_Homo sapiens_hsa052030.97121862
60Small cell lung cancer_Homo sapiens_hsa052220.96710665
61Staphylococcus aureus infection_Homo sapiens_hsa051500.94135605
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94090566
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93523355
64Viral myocarditis_Homo sapiens_hsa054160.93199073
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91943933
66Hematopoietic cell lineage_Homo sapiens_hsa046400.91859078
67Cholinergic synapse_Homo sapiens_hsa047250.91721899
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.91262555
69HTLV-I infection_Homo sapiens_hsa051660.90915725
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90690074
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90257409
72Taste transduction_Homo sapiens_hsa047420.89348062
73Vitamin B6 metabolism_Homo sapiens_hsa007500.89264886
74Ether lipid metabolism_Homo sapiens_hsa005650.88895087
75Epstein-Barr virus infection_Homo sapiens_hsa051690.88518976
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.87600337
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87502866
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87190512
79VEGF signaling pathway_Homo sapiens_hsa043700.85392452
80Arginine biosynthesis_Homo sapiens_hsa002200.84609507
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.84376265
82MAPK signaling pathway_Homo sapiens_hsa040100.83944459
83Biosynthesis of amino acids_Homo sapiens_hsa012300.83473470
84Fatty acid degradation_Homo sapiens_hsa000710.83322680
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82856757
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82601862
87Hepatitis B_Homo sapiens_hsa051610.82565916
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.82071534
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81862630
90Circadian entrainment_Homo sapiens_hsa047130.81298182
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.81090194
92Platelet activation_Homo sapiens_hsa046110.80713866
93Apoptosis_Homo sapiens_hsa042100.80520783
94TNF signaling pathway_Homo sapiens_hsa046680.80405900
95Pancreatic cancer_Homo sapiens_hsa052120.78076919
96Inositol phosphate metabolism_Homo sapiens_hsa005620.77523303
97Prolactin signaling pathway_Homo sapiens_hsa049170.76830539
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76729148
99Complement and coagulation cascades_Homo sapiens_hsa046100.76653980
100Phototransduction_Homo sapiens_hsa047440.76553359
101RNA transport_Homo sapiens_hsa030130.76143762
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74671234
103Pyruvate metabolism_Homo sapiens_hsa006200.73702850
104FoxO signaling pathway_Homo sapiens_hsa040680.73502536
105Bile secretion_Homo sapiens_hsa049760.72920783
106Rheumatoid arthritis_Homo sapiens_hsa053230.72426080
107GnRH signaling pathway_Homo sapiens_hsa049120.71541908
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71393786
109Glutamatergic synapse_Homo sapiens_hsa047240.71191120
110AMPK signaling pathway_Homo sapiens_hsa041520.71136657
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69210770
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69069910
113Fructose and mannose metabolism_Homo sapiens_hsa000510.68837274
114Shigellosis_Homo sapiens_hsa051310.68794219
115Non-small cell lung cancer_Homo sapiens_hsa052230.66865369
116Legionellosis_Homo sapiens_hsa051340.66794530
117Phagosome_Homo sapiens_hsa041450.66617324
118Cocaine addiction_Homo sapiens_hsa050300.65898699
119Sulfur relay system_Homo sapiens_hsa041220.65887993
120GABAergic synapse_Homo sapiens_hsa047270.65367650
121Hedgehog signaling pathway_Homo sapiens_hsa043400.63938065
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63651757
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63187581
124Olfactory transduction_Homo sapiens_hsa047400.63185554
125cAMP signaling pathway_Homo sapiens_hsa040240.63085779
126Long-term depression_Homo sapiens_hsa047300.62595423
127Oxytocin signaling pathway_Homo sapiens_hsa049210.62547838
128Adherens junction_Homo sapiens_hsa045200.61999964
129p53 signaling pathway_Homo sapiens_hsa041150.60878345
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60795270
131Endometrial cancer_Homo sapiens_hsa052130.60791368
132Malaria_Homo sapiens_hsa051440.60415926
133Ras signaling pathway_Homo sapiens_hsa040140.60216704
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60212461
135Chemokine signaling pathway_Homo sapiens_hsa040620.60081852
136HIF-1 signaling pathway_Homo sapiens_hsa040660.59851880
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.59374743
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.59300884
139MicroRNAs in cancer_Homo sapiens_hsa052060.59258201
140Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59024622
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.58910669
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.58621407
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58142104
144Insulin signaling pathway_Homo sapiens_hsa049100.57768080
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57482481
146Serotonergic synapse_Homo sapiens_hsa047260.57048314
147Carbon metabolism_Homo sapiens_hsa012000.56576863
148Type II diabetes mellitus_Homo sapiens_hsa049300.56398826
149Tryptophan metabolism_Homo sapiens_hsa003800.54803916
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54714064
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.54470687
152Calcium signaling pathway_Homo sapiens_hsa040200.54256961
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.54175085
154African trypanosomiasis_Homo sapiens_hsa051430.53335474
155Colorectal cancer_Homo sapiens_hsa052100.52386791
156Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51066456
157Endocytosis_Homo sapiens_hsa041440.50211685

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