LMBRD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.75767649
2central nervous system myelination (GO:0022010)4.75767649
3neuronal action potential propagation (GO:0019227)4.45805602
4L-amino acid import (GO:0043092)3.92104767
5presynaptic membrane assembly (GO:0097105)3.89343048
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.78283953
7presynaptic membrane organization (GO:0097090)3.70783042
8synaptic vesicle exocytosis (GO:0016079)3.66551624
9neuron cell-cell adhesion (GO:0007158)3.64783610
10gamma-aminobutyric acid transport (GO:0015812)3.63914098
11synaptic vesicle maturation (GO:0016188)3.59397954
12negative regulation of cell killing (GO:0031342)3.49625307
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49625307
14regulation of synaptic vesicle exocytosis (GO:2000300)3.49540987
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.47956419
16neurotransmitter-gated ion channel clustering (GO:0072578)3.47827743
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.43621090
18vocalization behavior (GO:0071625)3.41063731
19fatty acid elongation (GO:0030497)3.39850642
20negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38342684
21glutamate secretion (GO:0014047)3.36832655
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.33193658
23locomotory exploration behavior (GO:0035641)3.32130830
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.27486325
25negative regulation of neurotransmitter transport (GO:0051589)3.26240439
26cellular ketone body metabolic process (GO:0046950)3.23360378
27amino acid import (GO:0043090)3.20928931
28protein localization to synapse (GO:0035418)3.20295475
29glutamate receptor signaling pathway (GO:0007215)3.13685721
30synaptic transmission, glutamatergic (GO:0035249)3.08116929
31long-chain fatty acid biosynthetic process (GO:0042759)3.07707293
32negative regulation of protein oligomerization (GO:0032460)3.07198530
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.05566436
34regulation of synaptic vesicle transport (GO:1902803)3.05026507
35neuron-neuron synaptic transmission (GO:0007270)3.01548286
36negative regulation of neurotransmitter secretion (GO:0046929)3.00017296
37regulation of glutamate receptor signaling pathway (GO:1900449)2.99735447
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.92610674
39gamma-aminobutyric acid signaling pathway (GO:0007214)2.92445320
40cellular potassium ion homeostasis (GO:0030007)2.91716387
41positive regulation of cellular amide metabolic process (GO:0034250)2.91689813
42transmission of nerve impulse (GO:0019226)2.89855569
43inositol phosphate catabolic process (GO:0071545)2.88629328
44postsynaptic membrane organization (GO:0001941)2.88552022
45ketone body metabolic process (GO:1902224)2.88347519
46regulation of glucokinase activity (GO:0033131)2.87910260
47regulation of hexokinase activity (GO:1903299)2.87910260
48neurotransmitter secretion (GO:0007269)2.83741015
49regulation of neuronal synaptic plasticity (GO:0048168)2.83149917
50adult walking behavior (GO:0007628)2.82555871
51inositol phosphate dephosphorylation (GO:0046855)2.82413726
52phosphorylated carbohydrate dephosphorylation (GO:0046838)2.82413726
53neuromuscular process controlling posture (GO:0050884)2.81857597
54platelet dense granule organization (GO:0060155)2.81015298
55long-term memory (GO:0007616)2.79955972
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.79216655
57positive regulation of membrane potential (GO:0045838)2.77601379
58positive regulation of glycolytic process (GO:0045821)2.74883292
59acidic amino acid transport (GO:0015800)2.74179581
60regulation of beta-amyloid formation (GO:1902003)2.73710608
61long-term synaptic potentiation (GO:0060291)2.73080488
62regulation of long-term neuronal synaptic plasticity (GO:0048169)2.72034682
63regulation of excitatory postsynaptic membrane potential (GO:0060079)2.70853503
64neurotransmitter uptake (GO:0001504)2.69942627
65glycine transport (GO:0015816)2.69274592
66myelination (GO:0042552)2.67191055
67neurotransmitter transport (GO:0006836)2.64865055
68regulation of protein glycosylation (GO:0060049)2.63616559
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63505954
70ensheathment of neurons (GO:0007272)2.62088341
71axon ensheathment (GO:0008366)2.62088341
72cerebellar granule cell differentiation (GO:0021707)2.60630754
73response to methylmercury (GO:0051597)2.58838431
74response to auditory stimulus (GO:0010996)2.58815400
75L-glutamate transport (GO:0015813)2.58577086
76endocrine pancreas development (GO:0031018)2.57190507
77regulation of synaptic transmission, glutamatergic (GO:0051966)2.56635542
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.55143885
79negative regulation of complement activation (GO:0045916)2.54234589
80regulation of type B pancreatic cell apoptotic process (GO:2000674)2.52821943
81adaptation of signaling pathway (GO:0023058)2.51740981
82regulation of postsynaptic membrane potential (GO:0060078)2.51299538
83exploration behavior (GO:0035640)2.50527714
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49431813
85synaptic vesicle docking involved in exocytosis (GO:0016081)2.49364018
86microglial cell activation (GO:0001774)2.48743355
87regulation of neurotransmitter secretion (GO:0046928)2.48131854
88protein targeting to Golgi (GO:0000042)2.48039044
89positive regulation of insulin secretion (GO:0032024)2.47441117
90potassium ion import (GO:0010107)2.46311034
91cellular response to ethanol (GO:0071361)2.45489721
92neutrophil activation involved in immune response (GO:0002283)2.45126063
93regulation of amyloid precursor protein catabolic process (GO:1902991)2.44689660
94L-phenylalanine catabolic process (GO:0006559)2.44351786
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.44351786
96regulation of voltage-gated calcium channel activity (GO:1901385)2.44077816
97regulation of neurotransmitter levels (GO:0001505)2.43810276
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.43365750
99auditory behavior (GO:0031223)2.41806137
100detection of calcium ion (GO:0005513)2.41780134
101positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.40484609
102regulation of synaptic plasticity (GO:0048167)2.40315138
103polyol catabolic process (GO:0046174)2.40280471
104negative regulation of protein localization to cell surface (GO:2000009)2.40180882
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.39922614
106macrophage activation involved in immune response (GO:0002281)2.39510062
107behavioral response to cocaine (GO:0048148)2.38993944
108oligodendrocyte differentiation (GO:0048709)2.37895301
109import into cell (GO:0098657)2.37810265
110xenobiotic catabolic process (GO:0042178)2.37666376
111negative regulation of protein activation cascade (GO:2000258)2.37563859
112regulation of neurotransmitter transport (GO:0051588)2.36752897
113neuron recognition (GO:0008038)2.35690024
114insulin secretion (GO:0030073)2.35435134
115mechanosensory behavior (GO:0007638)2.31874048
116negative regulation of synaptic transmission (GO:0050805)2.31365783
117signal peptide processing (GO:0006465)2.30532530
118negative regulation of cytosolic calcium ion concentration (GO:0051481)2.30110074
119regulation of synaptic transmission, GABAergic (GO:0032228)2.30092279
120phospholipid homeostasis (GO:0055091)2.29579540
121regulation of glutamate secretion (GO:0014048)2.28999828
122startle response (GO:0001964)2.28842400
123neuronal ion channel clustering (GO:0045161)2.28154462
124positive regulation of synaptic transmission, GABAergic (GO:0032230)2.28141273
125dendritic spine morphogenesis (GO:0060997)2.27444639
126positive regulation of peptide hormone secretion (GO:0090277)2.27343404
127negative regulation of humoral immune response (GO:0002921)2.27223031
128positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.27196046
129membrane hyperpolarization (GO:0060081)2.27039209
130positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.26703386
131glycerophospholipid catabolic process (GO:0046475)2.26445235
132establishment of protein localization to Golgi (GO:0072600)2.25846527
133regulation of cellular amide metabolic process (GO:0034248)2.24880626
134macroautophagy (GO:0016236)2.24732046
135membrane depolarization (GO:0051899)2.24708516
136C4-dicarboxylate transport (GO:0015740)2.23703625
137regulation of vesicle fusion (GO:0031338)2.23546402
138epithelial cilium movement (GO:0003351)2.23095533
139retrograde transport, vesicle recycling within Golgi (GO:0000301)2.22900473
140regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.22880221
141brain morphogenesis (GO:0048854)2.22726263
142learning (GO:0007612)2.21326031
143positive regulation of peptide secretion (GO:0002793)2.20988717
144regulation of memory T cell differentiation (GO:0043380)2.20109209
145regulation of synapse structural plasticity (GO:0051823)2.19808291
146mating behavior (GO:0007617)2.19289408
147nitric oxide mediated signal transduction (GO:0007263)2.18230119
148negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.17320108
149adult locomotory behavior (GO:0008344)2.17133973
150heme transport (GO:0015886)2.16582576
151L-fucose catabolic process (GO:0042355)2.16168283
152fucose catabolic process (GO:0019317)2.16168283
153L-fucose metabolic process (GO:0042354)2.16168283
154reverse cholesterol transport (GO:0043691)2.16093706
155retinal cone cell development (GO:0046549)2.15672746
156erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.12486958
157L-phenylalanine metabolic process (GO:0006558)2.12486958
158negative regulation of lymphocyte mediated immunity (GO:0002707)2.11660597
159phagosome maturation (GO:0090382)2.11150808
160cellular response to interleukin-15 (GO:0071350)2.11128129
161ferric iron transport (GO:0015682)2.10642091
162trivalent inorganic cation transport (GO:0072512)2.10642091
163macrophage activation (GO:0042116)2.09317120
164negative regulation of protein autophosphorylation (GO:0031953)2.08515892
165peroxisome organization (GO:0007031)2.08275845
166axoneme assembly (GO:0035082)2.07624614
167protein localization to cilium (GO:0061512)2.07268967
168transcytosis (GO:0045056)2.06304804
169nucleotide transmembrane transport (GO:1901679)2.06245371
170regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.05997544
171regulation of triglyceride catabolic process (GO:0010896)2.03302954
172transferrin transport (GO:0033572)2.01662284
173negative regulation of neurological system process (GO:0031645)2.01028746
174sequestering of metal ion (GO:0051238)2.00244095
175positive regulation of phosphoprotein phosphatase activity (GO:0032516)1.99741594
176dopamine transport (GO:0015872)1.99184227
177neutrophil activation (GO:0042119)1.98695343
178negative regulation of execution phase of apoptosis (GO:1900118)1.98564975
179cilium movement (GO:0003341)1.98354750
180regulation of insulin secretion (GO:0050796)1.96790487
181cilium or flagellum-dependent cell motility (GO:0001539)1.96119946
182transepithelial transport (GO:0070633)1.95884987
183protein localization to Golgi apparatus (GO:0034067)1.95451440
184peptide hormone processing (GO:0016486)1.94496216
185epoxygenase P450 pathway (GO:0019373)1.94248116
186proline transport (GO:0015824)1.94183066
187high-density lipoprotein particle remodeling (GO:0034375)1.93626173
188negative regulation of glycoprotein biosynthetic process (GO:0010561)1.91670548
189peroxisome fission (GO:0016559)1.91669070
190lactate metabolic process (GO:0006089)1.90784375
191regulation of mononuclear cell migration (GO:0071675)1.90205213
192regulation of regulatory T cell differentiation (GO:0045589)1.90015433
193regulation of vacuole organization (GO:0044088)1.89195638
194positive regulation of respiratory burst (GO:0060267)1.89002515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.24299163
2GBX2_23144817_ChIP-Seq_PC3_Human3.62598541
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69965288
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64155346
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61405775
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59542160
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46041655
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23509422
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21030631
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16225416
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15477763
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15477763
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15452360
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15353559
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07709418
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.05645919
17TAF15_26573619_Chip-Seq_HEK293_Human2.05055720
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.00851976
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.94344146
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93293931
21AR_21572438_ChIP-Seq_LNCaP_Human1.90091184
22* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85161310
23REST_21632747_ChIP-Seq_MESCs_Mouse1.84386804
24DROSHA_22980978_ChIP-Seq_HELA_Human1.82727357
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.82288913
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82262103
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.81206692
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79422852
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75790696
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69993869
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.67031463
32* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61538268
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61450181
34* EZH2_27294783_Chip-Seq_NPCs_Mouse1.59683165
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.58813839
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53151063
37SMAD4_21799915_ChIP-Seq_A2780_Human1.49140296
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48537041
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48466692
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48319235
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48286195
42* P300_19829295_ChIP-Seq_ESCs_Human1.48139291
43* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46608228
44* RARB_27405468_Chip-Seq_BRAIN_Mouse1.44410770
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.42503247
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41496263
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41471685
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.41284422
49* NFE2_27457419_Chip-Seq_LIVER_Mouse1.40991452
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39052956
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38360800
52* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35477979
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34758726
54* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34135113
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33766816
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.31464911
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.30127784
58* CRX_20693478_ChIP-Seq_RETINA_Mouse1.28593021
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25842717
60SOX2_19829295_ChIP-Seq_ESCs_Human1.24274440
61NANOG_19829295_ChIP-Seq_ESCs_Human1.24274440
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24235281
63ER_23166858_ChIP-Seq_MCF-7_Human1.24207463
64* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23482863
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22465587
66HTT_18923047_ChIP-ChIP_STHdh_Human1.22260293
67CDX2_22108803_ChIP-Seq_LS180_Human1.21766812
68TCF4_22108803_ChIP-Seq_LS180_Human1.21361870
69IRF8_27001747_Chip-Seq_BMDM_Mouse1.21291602
70* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20960309
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19595439
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19351240
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19351240
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17569566
75STAT3_23295773_ChIP-Seq_U87_Human1.17502917
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.17032315
77* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16947988
78* AR_25329375_ChIP-Seq_VCAP_Human1.15381174
79* CBX2_27304074_Chip-Seq_ESCs_Mouse1.14671159
80* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14159557
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13724578
82VDR_22108803_ChIP-Seq_LS180_Human1.13415795
83* NANOG_18555785_Chip-Seq_ESCs_Mouse1.12860059
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11727026
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11457740
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10739106
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10489626
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10370325
89CBP_20019798_ChIP-Seq_JUKART_Human1.10370325
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09732064
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09378538
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08793464
93* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07527725
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07199484
95* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06386092
96RUNX_20019798_ChIP-Seq_JUKART_Human1.05915510
97FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05874026
98ZNF274_21170338_ChIP-Seq_K562_Hela1.05505158
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04549186
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04053387
101* PU1_27457419_Chip-Seq_LIVER_Mouse1.03876266
102* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03809220
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03093423
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.02287231
105* CMYC_18555785_Chip-Seq_ESCs_Mouse1.02047606
106TCF4_23295773_ChIP-Seq_U87_Human1.02036176
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01723614
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.01011532
109* NMYC_18555785_Chip-Seq_ESCs_Mouse1.00775680
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.00564643
111* OCT4_18555785_Chip-Seq_ESCs_Mouse1.00545599
112* P53_22387025_ChIP-Seq_ESCs_Mouse1.00452700
113* CTCF_18555785_Chip-Seq_ESCs_Mouse1.00294751
114EWS_26573619_Chip-Seq_HEK293_Human0.99863711
115FLI1_21867929_ChIP-Seq_TH2_Mouse0.99418745
116* E2F1_18555785_Chip-Seq_ESCs_Mouse0.99128357
117* RUNX2_22187159_ChIP-Seq_PCA_Human0.98804125
118TP53_18474530_ChIP-ChIP_U2OS_Human0.98749373
119* LXR_22158963_ChIP-Seq_LIVER_Mouse0.98335892
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96866287
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96530518
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.95920235
123* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95901023
124P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94684194
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94677005
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93418713
127* P300_18555785_Chip-Seq_ESCs_Mouse0.93165568
128* KDM2B_26808549_Chip-Seq_REH_Human0.92174432
129* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92057605
130AHR_22903824_ChIP-Seq_MCF-7_Human0.92036828
131* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92005424
132IGF1R_20145208_ChIP-Seq_DFB_Human0.91706511
133ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91556074
134* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91311905
135* STAT3_18555785_Chip-Seq_ESCs_Mouse0.90290953
136* SOX2_18555785_Chip-Seq_ESCs_Mouse0.89991652
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88999577
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.88062519
139WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87669320
140CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87423360
141BCAT_22108803_ChIP-Seq_LS180_Human0.87123952
142* FLI1_27457419_Chip-Seq_LIVER_Mouse0.86158633
143* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85779939
144TP53_16413492_ChIP-PET_HCT116_Human0.85658575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.33827022
2MP0004859_abnormal_synaptic_plasticity4.26966140
3MP0004270_analgesia3.23344696
4MP0003635_abnormal_synaptic_transmissio3.12262579
5MP0010234_abnormal_vibrissa_follicle3.08232760
6MP0009046_muscle_twitch3.06349592
7MP0002064_seizures2.97158910
8MP0009745_abnormal_behavioral_response2.87541975
9MP0006082_CNS_inflammation2.81915577
10MP0003724_increased_susceptibility_to2.81681967
11MP0002272_abnormal_nervous_system2.61069360
12MP0001486_abnormal_startle_reflex2.58019176
13MP0000920_abnormal_myelination2.54394187
14MP0003690_abnormal_glial_cell2.38806873
15MP0001968_abnormal_touch/_nociception2.38418278
16MP0002063_abnormal_learning/memory/cond2.37122406
17MP0000569_abnormal_digit_pigmentation2.34686589
18MP0003329_amyloid_beta_deposits2.26543894
19MP0005365_abnormal_bile_salt2.26508146
20MP0002572_abnormal_emotion/affect_behav2.24736859
21MP0002254_reproductive_system_inflammat2.22935628
22MP0002734_abnormal_mechanical_nocicepti2.14631016
23MP0005423_abnormal_somatic_nervous2.10066443
24MP0002837_dystrophic_cardiac_calcinosis2.05077819
25MP0002822_catalepsy2.03569806
26MP0001501_abnormal_sleep_pattern2.02824778
27MP0002736_abnormal_nociception_after1.90570391
28MP0004885_abnormal_endolymph1.90543269
29MP0002067_abnormal_sensory_capabilities1.85111034
30MP0004142_abnormal_muscle_tone1.84818929
31MP0001440_abnormal_grooming_behavior1.82163103
32MP0003300_gastrointestinal_ulcer1.78467643
33MP0003787_abnormal_imprinting1.78185740
34MP0008569_lethality_at_weaning1.76401297
35MP0005379_endocrine/exocrine_gland_phen1.74348370
36MP0002735_abnormal_chemical_nociception1.71743918
37MP0009785_altered_susceptibility_to1.67819777
38MP0001970_abnormal_pain_threshold1.67032739
39MP0005671_abnormal_response_to1.66347446
40MP0003136_yellow_coat_color1.66265244
41MP0005171_absent_coat_pigmentation1.65652607
42MP0003633_abnormal_nervous_system1.64057943
43MP0001905_abnormal_dopamine_level1.62733139
44MP0000604_amyloidosis1.55161585
45MP0004019_abnormal_vitamin_homeostasis1.54200281
46MP0004742_abnormal_vestibular_system1.53496328
47MP0002733_abnormal_thermal_nociception1.53453044
48MP0005646_abnormal_pituitary_gland1.52535880
49MP0010329_abnormal_lipoprotein_level1.52081957
50MP0003195_calcinosis1.48570469
51MP0002693_abnormal_pancreas_physiology1.44009278
52MP0004043_abnormal_pH_regulation1.42980990
53MP0003252_abnormal_bile_duct1.41423935
54MP0003634_abnormal_glial_cell1.41168007
55MP0005551_abnormal_eye_electrophysiolog1.40576304
56MP0001984_abnormal_olfaction1.40433785
57MP0003631_nervous_system_phenotype1.38634606
58MP0002876_abnormal_thyroid_physiology1.37948736
59MP0002229_neurodegeneration1.37820140
60MP0009780_abnormal_chondrocyte_physiolo1.35694057
61MP0008877_abnormal_DNA_methylation1.35072964
62MP0004924_abnormal_behavior1.34490621
63MP0005386_behavior/neurological_phenoty1.34490621
64MP0003122_maternal_imprinting1.33048654
65MP0005409_darkened_coat_color1.31368410
66MP0003075_altered_response_to1.31005227
67MP0000778_abnormal_nervous_system1.29589751
68MP0001502_abnormal_circadian_rhythm1.29263935
69MP0002557_abnormal_social/conspecific_i1.28853262
70MP0001756_abnormal_urination1.28299445
71MP0002138_abnormal_hepatobiliary_system1.28192853
72MP0002277_abnormal_respiratory_mucosa1.27852943
73MP0003045_fibrosis1.27823543
74MP0006072_abnormal_retinal_apoptosis1.26982474
75MP0008260_abnormal_autophagy1.26105134
76MP0002066_abnormal_motor_capabilities/c1.24727888
77MP0001790_abnormal_immune_system1.23608557
78MP0005387_immune_system_phenotype1.23608557
79MP0001529_abnormal_vocalization1.23077056
80MP0001666_abnormal_nutrient_absorption1.23019780
81MP0003868_abnormal_feces_composition1.21819454
82MP0005645_abnormal_hypothalamus_physiol1.19430837
83MP0004858_abnormal_nervous_system1.19212970
84MP0003879_abnormal_hair_cell1.15881170
85MP0006054_spinal_hemorrhage1.14427716
86MP0003632_abnormal_nervous_system1.14274104
87MP0002882_abnormal_neuron_morphology1.14209741
88MP0002139_abnormal_hepatobiliary_system1.12949489
89MP0005310_abnormal_salivary_gland1.12005191
90MP0006276_abnormal_autonomic_nervous1.11947234
91MP0005058_abnormal_lysosome_morphology1.10661160
92MP0001188_hyperpigmentation1.10575002
93MP0000955_abnormal_spinal_cord1.10386104
94MP0005174_abnormal_tail_pigmentation1.10121165
95MP0005636_abnormal_mineral_homeostasis1.09730667
96MP0001835_abnormal_antigen_presentation1.09014146
97MP0000465_gastrointestinal_hemorrhage1.08866499
98MP0002078_abnormal_glucose_homeostasis1.08722727
99MP0001944_abnormal_pancreas_morphology1.06923986
100MP0002184_abnormal_innervation1.01749622
101MP0001963_abnormal_hearing_physiology1.01321566
102MP0010678_abnormal_skin_adnexa1.00076613
103MP0002419_abnormal_innate_immunity0.99952726
104MP0002148_abnormal_hypersensitivity_rea0.99081911
105MP0003183_abnormal_peptide_metabolism0.98894143
106MP0005000_abnormal_immune_tolerance0.98358613
107MP0000013_abnormal_adipose_tissue0.97595520
108MP0005025_abnormal_response_to0.97496159
109MP0001177_atelectasis0.97277429
110MP0002090_abnormal_vision0.97215814
111MP0005535_abnormal_body_temperature0.96303978
112MP0001485_abnormal_pinna_reflex0.94500941
113MP0004811_abnormal_neuron_physiology0.93275357
114MP0002928_abnormal_bile_duct0.92926128
115MP0005084_abnormal_gallbladder_morpholo0.92719347
116MP0001845_abnormal_inflammatory_respons0.92186292
117MP0008875_abnormal_xenobiotic_pharmacok0.90754100
118MP0001986_abnormal_taste_sensitivity0.89133436
119MP0003283_abnormal_digestive_organ0.88777853
120MP0002909_abnormal_adrenal_gland0.88620274
121MP0001800_abnormal_humoral_immune0.87246500
122MP0008874_decreased_physiological_sensi0.86864871
123MP0005167_abnormal_blood-brain_barrier0.86601056
124MP0005464_abnormal_platelet_physiology0.86537511
125MP0002723_abnormal_immune_serum0.85226425
126MP0001764_abnormal_homeostasis0.84959727
127MP0004484_altered_response_of0.84610704
128MP0003866_abnormal_defecation0.84363997
129MP0008469_abnormal_protein_level0.82352995
130MP0004215_abnormal_myocardial_fiber0.81566471
131MP0005332_abnormal_amino_acid0.80638800
132MP0002132_abnormal_respiratory_system0.79247083
133MP0004147_increased_porphyrin_level0.79161573
134MP0004381_abnormal_hair_follicle0.73870774
135MP0010386_abnormal_urinary_bladder0.73686233
136MP0005360_urolithiasis0.73657638
137MP0005584_abnormal_enzyme/coenzyme_acti0.72985423
138MP0005410_abnormal_fertilization0.71719558
139MP0003011_delayed_dark_adaptation0.71432379
140MP0005085_abnormal_gallbladder_physiolo0.70098628
141MP0002069_abnormal_eating/drinking_beha0.69324829
142MP0002752_abnormal_somatic_nervous0.68696666
143MP0004145_abnormal_muscle_electrophysio0.68473039
144MP0003172_abnormal_lysosome_physiology0.67632680
145MP0001664_abnormal_digestion0.66844423
146MP0002638_abnormal_pupillary_reflex0.65588209
147MP0002118_abnormal_lipid_homeostasis0.63726329
148MP0005595_abnormal_vascular_smooth0.63465456
149MP0005253_abnormal_eye_physiology0.62846311
150MP0008872_abnormal_physiological_respon0.62788524
151MP0002152_abnormal_brain_morphology0.60318240
152MP0000372_irregular_coat_pigmentation0.60214425
153MP0005166_decreased_susceptibility_to0.59095856
154MP0001765_abnormal_ion_homeostasis0.58345845

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.17438332
2Neurofibrillary tangles (HP:0002185)4.54662859
3Myokymia (HP:0002411)4.47736786
4Hypoglycemic seizures (HP:0002173)3.86918464
5Focal seizures (HP:0007359)3.85211409
6Atonic seizures (HP:0010819)3.80993295
7Hyperinsulinemic hypoglycemia (HP:0000825)3.79634202
8Hypoglycemic coma (HP:0001325)3.76300829
9Epileptic encephalopathy (HP:0200134)3.63195001
10Progressive cerebellar ataxia (HP:0002073)3.63163269
11Supranuclear gaze palsy (HP:0000605)3.53029011
12Action tremor (HP:0002345)3.44309721
13Degeneration of the lateral corticospinal tracts (HP:0002314)3.27536989
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.27536989
15Febrile seizures (HP:0002373)3.26386242
16Cerebral inclusion bodies (HP:0100314)3.24258307
17Dysmetria (HP:0001310)3.22681632
18Hyperventilation (HP:0002883)3.21033347
19Scanning speech (HP:0002168)3.14829117
20Ketoacidosis (HP:0001993)3.10727710
21Dialeptic seizures (HP:0011146)3.05026141
22Absence seizures (HP:0002121)3.04900880
23Intention tremor (HP:0002080)2.93727859
24Generalized tonic-clonic seizures (HP:0002069)2.92972845
25Gaze-evoked nystagmus (HP:0000640)2.88599621
26Abnormality of the corticospinal tract (HP:0002492)2.83894768
27Hypothermia (HP:0002045)2.78511202
28Visual hallucinations (HP:0002367)2.76114489
29Broad-based gait (HP:0002136)2.75852721
30Large for gestational age (HP:0001520)2.72185974
31Abnormality of binocular vision (HP:0011514)2.69792262
32Diplopia (HP:0000651)2.69792262
33Symptomatic seizures (HP:0011145)2.67707846
34Peripheral hypomyelination (HP:0007182)2.63640283
35Abnormal eating behavior (HP:0100738)2.61244641
36Hyperglycemia (HP:0003074)2.59548316
37Abnormality of liposaccharide metabolism (HP:0010968)2.58498428
38Dysdiadochokinesis (HP:0002075)2.58174789
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.56689432
40Spastic gait (HP:0002064)2.54254050
41Anxiety (HP:0000739)2.53422808
42Increased CSF protein (HP:0002922)2.52804992
43Slow saccadic eye movements (HP:0000514)2.52417079
44Blue irides (HP:0000635)2.52266064
45Ankle clonus (HP:0011448)2.49294873
46Hemiparesis (HP:0001269)2.45376635
47Insulin-resistant diabetes mellitus (HP:0000831)2.43359732
48Pheochromocytoma (HP:0002666)2.40272327
49Parakeratosis (HP:0001036)2.38539577
50Truncal ataxia (HP:0002078)2.35084207
51Onion bulb formation (HP:0003383)2.34933222
52Metabolic alkalosis (HP:0200114)2.33335981
53Increased circulating renin level (HP:0000848)2.32417232
54Thyroiditis (HP:0100646)2.30065659
55Ketosis (HP:0001946)2.29830195
56Vacuolated lymphocytes (HP:0001922)2.29239199
57Amyloidosis (HP:0011034)2.28264958
58Progressive inability to walk (HP:0002505)2.26765719
59Abnormality of macrophages (HP:0004311)2.25509115
60Generalized myoclonic seizures (HP:0002123)2.25352939
61Depression (HP:0000716)2.23879796
62Postural instability (HP:0002172)2.23281619
63Hematochezia (HP:0002573)2.22587649
64Pancreatic islet-cell hyperplasia (HP:0004510)2.22475476
65Insidious onset (HP:0003587)2.22419173
66Termporal pattern (HP:0011008)2.22419173
67Steatorrhea (HP:0002570)2.22250493
68Clumsiness (HP:0002312)2.21144615
69Abnormality of the pancreatic islet cells (HP:0006476)2.20280477
70Abnormality of endocrine pancreas physiology (HP:0012093)2.20280477
71Retinal dysplasia (HP:0007973)2.19809463
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19653294
73Megalencephaly (HP:0001355)2.18101187
74Urinary bladder sphincter dysfunction (HP:0002839)2.16947360
75Recurrent gram-negative bacterial infections (HP:0005420)2.14284420
76Neuroendocrine neoplasm (HP:0100634)2.14190952
77Sensory axonal neuropathy (HP:0003390)2.13418526
78Mutism (HP:0002300)2.12420396
79Renal cortical cysts (HP:0000803)2.12207556
80Abnormality of saccadic eye movements (HP:0000570)2.11820791
81Abnormality of calcium-phosphate metabolism (HP:0100530)2.11775724
82Hemiplegia (HP:0002301)2.08908802
83Status epilepticus (HP:0002133)2.08257559
84Genetic anticipation (HP:0003743)2.07301052
85Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.06614504
86Neuronal loss in central nervous system (HP:0002529)2.01405938
87Fat malabsorption (HP:0002630)2.01279301
88Hypoproteinemia (HP:0003075)2.01177362
89Cerebral hemorrhage (HP:0001342)2.00655246
90Prolonged partial thromboplastin time (HP:0003645)1.99215614
91Poor eye contact (HP:0000817)1.99177690
92Hyperlipoproteinemia (HP:0010980)1.98738346
93Polyphagia (HP:0002591)1.97763695
94Aplasia involving bones of the upper limbs (HP:0009823)1.97304372
95Aplasia of the phalanges of the hand (HP:0009802)1.97304372
96Aplasia involving bones of the extremities (HP:0009825)1.97304372
97Lower limb muscle weakness (HP:0007340)1.97072368
98Glomerulonephritis (HP:0000099)1.96458239
99Eczematoid dermatitis (HP:0000976)1.96235726
100Akinesia (HP:0002304)1.95838038
101Recurrent bacterial skin infections (HP:0005406)1.95761856
102Abnormality of the renal cortex (HP:0011035)1.94612516
103Split foot (HP:0001839)1.94587971
104Potter facies (HP:0002009)1.94565151
105Facial shape deformation (HP:0011334)1.94565151
106Systemic lupus erythematosus (HP:0002725)1.93345170
107Axonal loss (HP:0003447)1.91785201
108Impaired vibration sensation in the lower limbs (HP:0002166)1.91207309
109Episodic fever (HP:0001954)1.90912483
110Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90106375
111Abnormality of polysaccharide metabolism (HP:0011012)1.90106375
112Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90106375
113Ventricular fibrillation (HP:0001663)1.89833826
114Torticollis (HP:0000473)1.89136226
115Medial flaring of the eyebrow (HP:0010747)1.88160085
116Abnormal ciliary motility (HP:0012262)1.86988352
117Optic neuritis (HP:0100653)1.86775329
118Retrobulbar optic neuritis (HP:0100654)1.86775329
119Abnormality of urine glucose concentration (HP:0011016)1.86743933
120Glycosuria (HP:0003076)1.86743933
121Hypomagnesemia (HP:0002917)1.86036575
122Hypokalemic alkalosis (HP:0001949)1.85831809
123Urinary glycosaminoglycan excretion (HP:0003541)1.85735443
124Mucopolysacchariduria (HP:0008155)1.85735443
125Progressive neurologic deterioration (HP:0002344)1.85296967
126Psychosis (HP:0000709)1.85247681
127* Stomatitis (HP:0010280)1.84204655
128Postural tremor (HP:0002174)1.83392728
129Impaired social interactions (HP:0000735)1.83216521
130Abnormal social behavior (HP:0012433)1.83216521
131Agitation (HP:0000713)1.82819913
132Chronic diarrhea (HP:0002028)1.82757428
133Thickened helices (HP:0000391)1.82261566
134Spastic tetraparesis (HP:0001285)1.81977499
135Rigidity (HP:0002063)1.81008991
136Tongue fasciculations (HP:0001308)1.80574714
137Conjunctival hamartoma (HP:0100780)1.80409621
138Excessive salivation (HP:0003781)1.80212011
139Drooling (HP:0002307)1.80212011
140Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79535274
141Muscle fibrillation (HP:0010546)1.78747487
142Absent/shortened dynein arms (HP:0200106)1.78595820
143Dynein arm defect of respiratory motile cilia (HP:0012255)1.78595820
144Abnormal drinking behavior (HP:0030082)1.78180146
145Polydipsia (HP:0001959)1.78180146
146Absent speech (HP:0001344)1.76462449
147Hypophosphatemic rickets (HP:0004912)1.76109289
148Rhinitis (HP:0012384)1.76071582
149Inability to walk (HP:0002540)1.75393208
150Epileptiform EEG discharges (HP:0011182)1.75043987
151* Abnormality of vitamin B metabolism (HP:0004340)1.75029427
152Malnutrition (HP:0004395)1.74430541
153Keratoconjunctivitis (HP:0001096)1.73290046
154Abnormality of magnesium homeostasis (HP:0004921)1.72701007
155Focal dystonia (HP:0004373)1.72432687
156Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72389502
157Gait ataxia (HP:0002066)1.71693424
158Loss of speech (HP:0002371)1.71269085
159Impaired vibratory sensation (HP:0002495)1.70542728
160Orchitis (HP:0100796)1.69628648
161Urinary urgency (HP:0000012)1.69396350
162Recurrent abscess formation (HP:0002722)1.69368020
163Xanthomatosis (HP:0000991)1.68923586
164Abnormality of glycosphingolipid metabolism (HP:0004343)1.68156252
165Abnormality of glycolipid metabolism (HP:0010969)1.68156252
166Abnormal biliary tract physiology (HP:0012439)1.68029991
167Bile duct proliferation (HP:0001408)1.68029991
168Abnormality of renin-angiotensin system (HP:0000847)1.66510700
169Irritability (HP:0000737)1.65643448
170Myositis (HP:0100614)1.65228947
171Recurrent skin infections (HP:0001581)1.64702152
172Abnormal respiratory motile cilium physiology (HP:0012261)1.64206678
173Brushfield spots (HP:0001088)1.64115877
174Progressive macrocephaly (HP:0004481)1.64068091
175Retinal atrophy (HP:0001105)1.63959734
176Joint swelling (HP:0001386)1.63541055
177Enlarged penis (HP:0000040)1.63114489
178Vascular calcification (HP:0004934)1.62477480
179Hyperactive renin-angiotensin system (HP:0000841)1.61849150
180Epidermoid cyst (HP:0200040)1.61029412

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.65315238
2CASK3.77753570
3EPHA42.92624039
4TNIK2.83923043
5NTRK32.82247010
6STK392.63700752
7OXSR12.62783750
8MAP2K72.41888679
9TXK2.35636240
10PRPF4B2.27412191
11RIPK42.23935007
12ACVR1B2.16978209
13MAP4K22.05775851
14WNK32.03883643
15MAP3K41.82643525
16DAPK21.79022149
17TAOK31.76725504
18NTRK11.65455126
19SGK4941.64021928
20SGK2231.64021928
21CDK191.62169936
22EPHA31.60706155
23MUSK1.50859796
24MAP3K91.49453689
25STK241.47819522
26CAMKK21.46770541
27ERBB31.42268866
28MARK11.41556413
29NTRK21.41019958
30MAP2K41.40183416
31MINK11.39928246
32FES1.39621397
33MAP3K121.37821916
34PKN11.35891189
35MAPKAPK51.35718386
36TYK21.35591391
37BMPR21.34398502
38PAK61.29055092
39BLK1.28040941
40PASK1.27991143
41CAMK2B1.25333948
42ARAF1.25169194
43NEK61.24719551
44CDK51.20485189
45JAK11.18725330
46EPHB11.16806109
47PINK11.14337930
48WNK11.14163138
49WNK41.12083404
50CAMKK11.11407679
51INSRR1.10614347
52CAMK2A1.10601852
53FER1.08971672
54TRIM281.07603743
55FGFR31.06363008
56GRK51.06072049
57SGK21.03732035
58MAP3K131.03420424
59UHMK11.03038556
60MAPK131.02150217
61ITK1.01507963
62PHKG11.00669480
63PHKG21.00669480
64YES10.98936348
65CSK0.97121141
66PBK0.95957717
67FGR0.94340560
68PLK20.93898063
69IKBKE0.93085379
70PRKCE0.91689614
71CAMK2D0.91575763
72PRKCH0.90899696
73PRKCG0.90769000
74CAMK2G0.89005444
75BMPR1B0.85559887
76BCR0.84677537
77CSNK1G20.84294002
78GRK70.82962975
79MAP3K20.82700673
80PRKD30.81133422
81PDPK10.80356534
82IRAK20.80252358
83KSR20.78830281
84STK38L0.75823885
85STK380.75761416
86SYK0.75044751
87LYN0.73582902
88CAMK10.72756957
89GRK60.72195833
90SGK30.70747917
91PRKCQ0.70485494
92FGFR20.68940150
93IKBKB0.68123125
94JAK20.66273919
95MAP3K10.65458968
96CSNK1G10.64093818
97CSF1R0.63915442
98SGK10.63019345
99PDK10.61514869
100DYRK1A0.60490402
101TEC0.59269547
102ROCK20.58639794
103CSNK1G30.58628293
104HCK0.58331213
105STK110.57512223
106TRPM70.57406748
107PRKAA20.57163902
108ADRBK20.57111997
109CSNK1A1L0.57026874
110PRKD20.56891380
111MAP2K60.55941091
112TGFBR20.55890593
113LMTK20.54298111
114PAK30.53305948
115MAPK120.53199125
116FYN0.52363130
117CDK140.50705226
118MAP3K50.49856177
119PNCK0.49031275
120EIF2AK30.48177322
121MAP3K140.47840700
122IRAK10.47663789
123MAP4K10.47505190
124PIK3CG0.47434414
125MAPK70.46805566
126MARK20.46046967
127PDK20.45790627
128MST40.45721770
129ZAP700.45419894
130IRAK40.45364111
131SIK30.45082023
132CDK150.44862260
133NLK0.44822425
134PTK2B0.44817767
135PRKG10.44233076
136CDK180.43826587
137CSNK1A10.43353542
138BTK0.43331386
139GRK10.42571004
140TNK20.42457627
141AKT30.41618646
142PRKACA0.41073029

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.69076800
2Nicotine addiction_Homo sapiens_hsa050332.84905504
3Synaptic vesicle cycle_Homo sapiens_hsa047212.54573328
4GABAergic synapse_Homo sapiens_hsa047272.27498739
5Nitrogen metabolism_Homo sapiens_hsa009102.25457707
6Glutamatergic synapse_Homo sapiens_hsa047242.12623745
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10211301
8Morphine addiction_Homo sapiens_hsa050321.97982756
9Collecting duct acid secretion_Homo sapiens_hsa049661.97071262
10Protein export_Homo sapiens_hsa030601.88360203
11Fatty acid elongation_Homo sapiens_hsa000621.85956514
12Circadian entrainment_Homo sapiens_hsa047131.85005173
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75896937
14Salivary secretion_Homo sapiens_hsa049701.69802352
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67226374
16Olfactory transduction_Homo sapiens_hsa047401.66534301
17Circadian rhythm_Homo sapiens_hsa047101.65348896
18Steroid biosynthesis_Homo sapiens_hsa001001.59886100
19Amphetamine addiction_Homo sapiens_hsa050311.52802923
20Long-term potentiation_Homo sapiens_hsa047201.52297860
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51959220
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45357544
23Serotonergic synapse_Homo sapiens_hsa047261.43525571
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43488464
25Long-term depression_Homo sapiens_hsa047301.39395987
26Tryptophan metabolism_Homo sapiens_hsa003801.38872120
27Insulin secretion_Homo sapiens_hsa049111.38655553
28Caffeine metabolism_Homo sapiens_hsa002321.37221831
29Taste transduction_Homo sapiens_hsa047421.36603961
30Gastric acid secretion_Homo sapiens_hsa049711.33300553
31Dopaminergic synapse_Homo sapiens_hsa047281.31833525
32Chemical carcinogenesis_Homo sapiens_hsa052041.27623498
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26587845
34Cholinergic synapse_Homo sapiens_hsa047251.22703484
35Cocaine addiction_Homo sapiens_hsa050301.22264461
36Ether lipid metabolism_Homo sapiens_hsa005651.20587407
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18646389
38beta-Alanine metabolism_Homo sapiens_hsa004101.18565781
39Fatty acid degradation_Homo sapiens_hsa000711.17903460
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17870926
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15731097
42Renin secretion_Homo sapiens_hsa049241.15456339
43Vibrio cholerae infection_Homo sapiens_hsa051101.13855509
44Butanoate metabolism_Homo sapiens_hsa006501.12874359
45Autoimmune thyroid disease_Homo sapiens_hsa053201.10733620
46Calcium signaling pathway_Homo sapiens_hsa040201.09227251
47Allograft rejection_Homo sapiens_hsa053301.08667175
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07965749
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.06944322
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06463850
51Retinol metabolism_Homo sapiens_hsa008301.05902188
52Rheumatoid arthritis_Homo sapiens_hsa053231.01851472
53Graft-versus-host disease_Homo sapiens_hsa053321.01041973
54Phototransduction_Homo sapiens_hsa047441.00579633
55Linoleic acid metabolism_Homo sapiens_hsa005911.00367492
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.95474956
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94725642
58Sphingolipid metabolism_Homo sapiens_hsa006000.93694868
59PPAR signaling pathway_Homo sapiens_hsa033200.91914175
60Arachidonic acid metabolism_Homo sapiens_hsa005900.90382846
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87910520
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87628309
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85890443
64Sulfur metabolism_Homo sapiens_hsa009200.85666530
65Histidine metabolism_Homo sapiens_hsa003400.85326316
66Arginine biosynthesis_Homo sapiens_hsa002200.85159575
67Oxidative phosphorylation_Homo sapiens_hsa001900.85012027
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84513509
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82392952
70cAMP signaling pathway_Homo sapiens_hsa040240.81320435
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81251792
72Bile secretion_Homo sapiens_hsa049760.80396243
73Lysosome_Homo sapiens_hsa041420.80003094
74Oxytocin signaling pathway_Homo sapiens_hsa049210.79923103
75Pancreatic secretion_Homo sapiens_hsa049720.79004552
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78632715
77Vitamin B6 metabolism_Homo sapiens_hsa007500.76599642
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75689101
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73999273
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73886403
81GnRH signaling pathway_Homo sapiens_hsa049120.73805496
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71648533
83Axon guidance_Homo sapiens_hsa043600.71516499
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70878033
85Starch and sucrose metabolism_Homo sapiens_hsa005000.67227778
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66200966
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65812503
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.65436641
89Asthma_Homo sapiens_hsa053100.64126924
90Phagosome_Homo sapiens_hsa041450.63506360
91Alzheimers disease_Homo sapiens_hsa050100.62843706
92Fatty acid biosynthesis_Homo sapiens_hsa000610.62776724
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.62440952
94African trypanosomiasis_Homo sapiens_hsa051430.62412927
95Complement and coagulation cascades_Homo sapiens_hsa046100.62353836
96Fatty acid metabolism_Homo sapiens_hsa012120.61928068
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.61666564
98Gap junction_Homo sapiens_hsa045400.61525932
99Fat digestion and absorption_Homo sapiens_hsa049750.61257790
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.61197152
101Staphylococcus aureus infection_Homo sapiens_hsa051500.61031808
102Peroxisome_Homo sapiens_hsa041460.58493338
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58327316
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.57804837
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57649757
106Osteoclast differentiation_Homo sapiens_hsa043800.56823194
107Tuberculosis_Homo sapiens_hsa051520.56228735
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55579477
109Mineral absorption_Homo sapiens_hsa049780.55556650
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53606004
111Hematopoietic cell lineage_Homo sapiens_hsa046400.53039423
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51889038
113Folate biosynthesis_Homo sapiens_hsa007900.51687477
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.51359088
115Primary immunodeficiency_Homo sapiens_hsa053400.51155227
116Chemokine signaling pathway_Homo sapiens_hsa040620.50448633
117Antigen processing and presentation_Homo sapiens_hsa046120.50240060
118Prion diseases_Homo sapiens_hsa050200.50048992
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49860768
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49624850
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49337644
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49135841
123Thyroid hormone synthesis_Homo sapiens_hsa049180.48623212
124Parkinsons disease_Homo sapiens_hsa050120.48440182
125ABC transporters_Homo sapiens_hsa020100.47350588
126Type II diabetes mellitus_Homo sapiens_hsa049300.47178015
127Dorso-ventral axis formation_Homo sapiens_hsa043200.46918970
128Type I diabetes mellitus_Homo sapiens_hsa049400.46830079
129Ovarian steroidogenesis_Homo sapiens_hsa049130.46733653
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46208103
131Cardiac muscle contraction_Homo sapiens_hsa042600.44022264
132Regulation of autophagy_Homo sapiens_hsa041400.43380691
133Propanoate metabolism_Homo sapiens_hsa006400.43278013
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42491943
135ErbB signaling pathway_Homo sapiens_hsa040120.42094325
136Ras signaling pathway_Homo sapiens_hsa040140.41441501
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40955310

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