LMBRD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)4.70271730
2sodium ion export (GO:0071436)4.62626411
3urea metabolic process (GO:0019627)4.15337400
4urea cycle (GO:0000050)4.15337400
5L-phenylalanine catabolic process (GO:0006559)4.11640651
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.11640651
7cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.09326761
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.06826186
9aromatic amino acid family catabolic process (GO:0009074)3.98351377
10dicarboxylic acid biosynthetic process (GO:0043650)3.84793847
11tryptophan catabolic process (GO:0006569)3.80724923
12indole-containing compound catabolic process (GO:0042436)3.80724923
13indolalkylamine catabolic process (GO:0046218)3.80724923
14positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.71668862
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.70807989
16tryptophan metabolic process (GO:0006568)3.69515579
17L-phenylalanine metabolic process (GO:0006558)3.67383832
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.67383832
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.63045568
20nitrogen cycle metabolic process (GO:0071941)3.60910008
21alpha-linolenic acid metabolic process (GO:0036109)3.60240062
22bile acid biosynthetic process (GO:0006699)3.60172860
23kynurenine metabolic process (GO:0070189)3.55517177
24cerebellar granule cell differentiation (GO:0021707)3.50254964
25cell communication by electrical coupling (GO:0010644)3.48627470
26positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.41947016
27cellular sodium ion homeostasis (GO:0006883)3.41039774
28peptidyl-glutamic acid carboxylation (GO:0017187)3.39639686
29protein carboxylation (GO:0018214)3.39639686
30pyrimidine nucleobase catabolic process (GO:0006208)3.39522330
31complement activation, alternative pathway (GO:0006957)3.37469993
32regulation of cell communication by electrical coupling (GO:0010649)3.36686033
33glutamate secretion (GO:0014047)3.34724852
34high-density lipoprotein particle remodeling (GO:0034375)3.33686167
35potassium ion import (GO:0010107)3.31599870
36regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.30656642
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.30213435
38cerebellar Purkinje cell differentiation (GO:0021702)3.29782796
39detection of calcium ion (GO:0005513)3.29167166
40regulation of synaptic vesicle transport (GO:1902803)3.29087997
41homocysteine metabolic process (GO:0050667)3.28474205
42relaxation of cardiac muscle (GO:0055119)3.27939987
43regulation of protein activation cascade (GO:2000257)3.26761694
44glutamate metabolic process (GO:0006536)3.26560004
45positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.24258148
46bile acid metabolic process (GO:0008206)3.17211470
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.15513469
48neurotransmitter-gated ion channel clustering (GO:0072578)3.15510912
49nucleobase catabolic process (GO:0046113)3.14637014
50potassium ion homeostasis (GO:0055075)3.14501540
51glutamate receptor signaling pathway (GO:0007215)3.14283434
52negative regulation of fibrinolysis (GO:0051918)3.13790186
53locomotory exploration behavior (GO:0035641)3.12756059
54Golgi to endosome transport (GO:0006895)3.09981707
55regulation of fibrinolysis (GO:0051917)3.09448730
56positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.09368494
57positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.09112641
58cysteine metabolic process (GO:0006534)3.08970162
59regulation of short-term neuronal synaptic plasticity (GO:0048172)3.08757419
60neuron-neuron synaptic transmission (GO:0007270)3.06890175
61cell communication involved in cardiac conduction (GO:0086065)3.06601583
62drug catabolic process (GO:0042737)3.05689372
63reverse cholesterol transport (GO:0043691)3.04866272
64regulation of complement activation (GO:0030449)3.04108322
65regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.02321679
66lysine metabolic process (GO:0006553)3.01828879
67lysine catabolic process (GO:0006554)3.01828879
68regulation of ARF protein signal transduction (GO:0032012)3.01726857
69regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.01550124
70cholesterol efflux (GO:0033344)3.00839160
71tyrosine metabolic process (GO:0006570)2.99342355
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.97600833
73negative regulation of dendrite morphogenesis (GO:0050774)2.95672065
74glyoxylate metabolic process (GO:0046487)2.95257116
75synaptic vesicle maturation (GO:0016188)2.94309494
76protein-lipid complex remodeling (GO:0034368)2.93781375
77macromolecular complex remodeling (GO:0034367)2.93781375
78plasma lipoprotein particle remodeling (GO:0034369)2.93781375
79nerve growth factor signaling pathway (GO:0038180)2.93542523
80phospholipid homeostasis (GO:0055091)2.92517499
81negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90494392
82synaptic transmission, glutamatergic (GO:0035249)2.88648132
83regulation of neuronal synaptic plasticity (GO:0048168)2.86593971
84bile acid and bile salt transport (GO:0015721)2.86030300
85L-amino acid import (GO:0043092)2.85979123
86righting reflex (GO:0060013)2.85521812
87macroautophagy (GO:0016236)2.85050105
88cellular ketone body metabolic process (GO:0046950)2.84577110
89vesicle transport along microtubule (GO:0047496)2.83765454
90sulfur amino acid catabolic process (GO:0000098)2.83454610
91indolalkylamine metabolic process (GO:0006586)2.83089310
92gamma-aminobutyric acid transport (GO:0015812)2.82807766
93serine family amino acid catabolic process (GO:0009071)2.81968470
94clathrin coat assembly (GO:0048268)2.81438826
95vocalization behavior (GO:0071625)2.80862120
96neuronal action potential propagation (GO:0019227)2.80830902
97protein targeting to Golgi (GO:0000042)2.79941516
98aromatic amino acid family metabolic process (GO:0009072)2.79701923
99regulation of bile acid biosynthetic process (GO:0070857)2.79052870
100positive regulation of lipid catabolic process (GO:0050996)2.77162960
101negative regulation of neurotransmitter secretion (GO:0046929)2.77118113
102serotonin metabolic process (GO:0042428)2.77092641
103regulation of beta-amyloid formation (GO:1902003)2.76458696
104exploration behavior (GO:0035640)2.75020895
105positive regulation of fatty acid beta-oxidation (GO:0032000)2.72952706
106indole-containing compound metabolic process (GO:0042430)2.72390190
107exogenous drug catabolic process (GO:0042738)2.71897841
108regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.71732673
109cellular response to ethanol (GO:0071361)2.71561155
110phospholipid efflux (GO:0033700)2.71353648
111triglyceride homeostasis (GO:0070328)2.70376258
112acylglycerol homeostasis (GO:0055090)2.70376258
113alpha-amino acid catabolic process (GO:1901606)2.69436377
114neuron cell-cell adhesion (GO:0007158)2.68854999
115synaptic vesicle exocytosis (GO:0016079)2.68589161
116neurotransmitter transport (GO:0006836)2.68342518
117coenzyme catabolic process (GO:0009109)2.67094006
118establishment of protein localization to Golgi (GO:0072600)2.66936084
119regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.66928587
120amino acid import (GO:0043090)2.65779046
121relaxation of smooth muscle (GO:0044557)2.65430291
122cellular modified amino acid catabolic process (GO:0042219)2.65002897
123very-low-density lipoprotein particle assembly (GO:0034379)2.64501809
124regulation of cholesterol homeostasis (GO:2000188)2.64477496
125relaxation of muscle (GO:0090075)2.64446332
126regulation of long-term neuronal synaptic plasticity (GO:0048169)2.64389627
127regulation of neurotransmitter secretion (GO:0046928)2.63819333
128negative regulation of cholesterol transport (GO:0032375)2.62310895
129negative regulation of sterol transport (GO:0032372)2.62310895
130regulation of glutamate receptor signaling pathway (GO:1900449)2.61807727
131positive regulation of potassium ion transport (GO:0043268)2.61246601
132plasma lipoprotein particle assembly (GO:0034377)2.59890062
133membrane depolarization during action potential (GO:0086010)2.58371058
134regulation of synaptic vesicle exocytosis (GO:2000300)2.58045034
135alanine transport (GO:0032328)2.57881827
136proline transport (GO:0015824)2.57248499
137regulation of dendritic spine morphogenesis (GO:0061001)2.56097867
138regulation of dendritic spine development (GO:0060998)2.55660944
139drug transmembrane transport (GO:0006855)2.55166900
140regulation of protein glycosylation (GO:0060049)2.54757478
141neurotransmitter secretion (GO:0007269)2.54721073
142negative regulation of neurotransmitter transport (GO:0051589)2.54485123
143startle response (GO:0001964)2.54048008
144regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.52200407
145regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51841965
146synaptic vesicle endocytosis (GO:0048488)2.51325030
147positive regulation of muscle hypertrophy (GO:0014742)2.51003694
148positive regulation of cardiac muscle hypertrophy (GO:0010613)2.51003694
149regulation of cholesterol esterification (GO:0010872)2.50530918
150ketone body metabolic process (GO:1902224)2.49466297
151inositol phosphate-mediated signaling (GO:0048016)2.49393671
152cellular amino acid catabolic process (GO:0009063)2.49008212
153regulation of triglyceride catabolic process (GO:0010896)2.48520465
154regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.48488602
155regulation of clathrin-mediated endocytosis (GO:2000369)2.48356376
156retrograde transport, vesicle recycling within Golgi (GO:0000301)2.47740352
157positive regulation of potassium ion transmembrane transport (GO:1901381)2.47635147
158plasma lipoprotein particle clearance (GO:0034381)2.47035126
159regulation of voltage-gated calcium channel activity (GO:1901385)2.46763930
160positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.46692587
161cell differentiation in hindbrain (GO:0021533)2.46332903
162cellular glucuronidation (GO:0052695)2.46060362
163long-term synaptic potentiation (GO:0060291)2.45750549
164lipoprotein metabolic process (GO:0042157)2.45412859
165regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.45158312
166low-density lipoprotein particle remodeling (GO:0034374)2.45000343
167intestinal cholesterol absorption (GO:0030299)2.44963253
168organelle transport along microtubule (GO:0072384)2.44348516
169phosphorelay signal transduction system (GO:0000160)2.41672310
170regulation of synaptic plasticity (GO:0048167)2.41239281
171protein localization to synapse (GO:0035418)2.39260439
172sarcoplasmic reticulum calcium ion transport (GO:0070296)2.38752532
173regulation of neurotransmitter levels (GO:0001505)2.37574686
174regulation of calcium ion transmembrane transport (GO:1903169)2.36751211
175regulation of calcium ion transmembrane transporter activity (GO:1901019)2.36751211
176cardiac conduction (GO:0061337)2.36050682
177regulation of cardiac muscle cell contraction (GO:0086004)2.35638727
178regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.35187349
179regulation of neurotransmitter transport (GO:0051588)2.34809571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.47500588
2GBX2_23144817_ChIP-Seq_PC3_Human3.18343820
3RXR_22158963_ChIP-Seq_LIVER_Mouse2.75682671
4LXR_22158963_ChIP-Seq_LIVER_Mouse2.53989515
5EZH2_22144423_ChIP-Seq_EOC_Human2.49707523
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45985725
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.15132232
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.10985443
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05357957
10SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01798494
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97955947
12TAF15_26573619_Chip-Seq_HEK293_Human1.95429788
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.93574955
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.86755481
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85811630
16GATA1_22025678_ChIP-Seq_K562_Human1.85441958
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81296318
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79194674
19SMAD4_21799915_ChIP-Seq_A2780_Human1.78243596
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76138262
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.70082272
22* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66779740
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66071484
24P300_19829295_ChIP-Seq_ESCs_Human1.56707315
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55205837
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52683716
27* STAT3_23295773_ChIP-Seq_U87_Human1.51272313
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50488794
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47784812
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.46143353
31AR_21572438_ChIP-Seq_LNCaP_Human1.44185064
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.44151382
33DROSHA_22980978_ChIP-Seq_HELA_Human1.43321357
34REST_21632747_ChIP-Seq_MESCs_Mouse1.40820604
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40756751
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.40184006
37SOX2_21211035_ChIP-Seq_LN229_Gbm1.39799837
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.37989191
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37793469
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36227090
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.35613901
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.35418677
43AR_25329375_ChIP-Seq_VCAP_Human1.34372535
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34355622
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34107597
46IGF1R_20145208_ChIP-Seq_DFB_Human1.33117827
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32981299
48AHR_22903824_ChIP-Seq_MCF-7_Human1.31478736
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29978049
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29680336
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29680336
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.29679692
53TP53_16413492_ChIP-PET_HCT116_Human1.29657452
54SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28921129
55TCF4_23295773_ChIP-Seq_U87_Human1.28582485
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.27314778
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25834814
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25427507
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.24200845
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24071487
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23273801
62* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22231646
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.21912006
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21660844
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21373035
66BCAT_22108803_ChIP-Seq_LS180_Human1.20978199
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20856885
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20846400
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19547984
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19360943
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.19236827
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19209462
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19206178
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18833530
75TP53_18474530_ChIP-ChIP_U2OS_Human1.18173007
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18006739
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17982099
78EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17982099
79RXR_22108803_ChIP-Seq_LS180_Human1.16466320
80SOX2_18555785_Chip-Seq_ESCs_Mouse1.16222662
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15614052
82EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14901581
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14467626
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14417669
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.14166444
86AR_19668381_ChIP-Seq_PC3_Human1.13980499
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.12247810
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.11026076
89* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10717853
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10160644
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09905193
92P300_18555785_Chip-Seq_ESCs_Mouse1.08368471
93NMYC_18555785_Chip-Seq_ESCs_Mouse1.08028125
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05858085
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05623022
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.05418225
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05140866
98OCT4_18555785_Chip-Seq_ESCs_Mouse1.05113558
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04988604
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04268110
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04002594
102REST_18959480_ChIP-ChIP_MESCs_Mouse1.03918673
103ER_23166858_ChIP-Seq_MCF-7_Human1.03902109
104TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03869853
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.03038415
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02444438
107FLI1_27457419_Chip-Seq_LIVER_Mouse1.02122180
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00407160
109EED_16625203_ChIP-ChIP_MESCs_Mouse1.00318026
110RUNX2_22187159_ChIP-Seq_PCA_Human0.99765786
111ZNF274_21170338_ChIP-Seq_K562_Hela0.99406174
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99000625
113FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98097536
114KDM2B_26808549_Chip-Seq_REH_Human0.97411056
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96591307
116RNF2_27304074_Chip-Seq_ESCs_Mouse0.96565939
117CBP_20019798_ChIP-Seq_JUKART_Human0.96438700
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96438700
119FUS_26573619_Chip-Seq_HEK293_Human0.96025241
120CMYC_18555785_Chip-Seq_ESCs_Mouse0.95482604
121P53_22387025_ChIP-Seq_ESCs_Mouse0.94817178
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94060089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.83630020
2MP0005360_urolithiasis5.59614510
3MP0005085_abnormal_gallbladder_physiolo4.73365882
4MP0005365_abnormal_bile_salt4.46886847
5MP0004859_abnormal_synaptic_plasticity3.73062261
6MP0000569_abnormal_digit_pigmentation3.50976735
7MP0003252_abnormal_bile_duct3.40861952
8MP0009780_abnormal_chondrocyte_physiolo3.32299257
9MP0008875_abnormal_xenobiotic_pharmacok3.11964218
10MP0010329_abnormal_lipoprotein_level2.79101838
11MP0005423_abnormal_somatic_nervous2.61327391
12MP0003195_calcinosis2.52098915
13MP0004270_analgesia2.48249710
14MP0008057_abnormal_DNA_replication2.41244349
15MP0003635_abnormal_synaptic_transmissio2.24007726
16MP0002063_abnormal_learning/memory/cond2.01017658
17MP0003868_abnormal_feces_composition1.98895466
18MP0010234_abnormal_vibrissa_follicle1.88061942
19MP0002009_preneoplasia1.83635417
20MP0008569_lethality_at_weaning1.78493936
21MP0009745_abnormal_behavioral_response1.78467445
22MP0001666_abnormal_nutrient_absorption1.77532534
23MP0005332_abnormal_amino_acid1.76152475
24MP0003880_abnormal_central_pattern1.68864825
25MP0009046_muscle_twitch1.65561063
26MP0004484_altered_response_of1.61825808
27MP0004742_abnormal_vestibular_system1.59516220
28MP0004215_abnormal_myocardial_fiber1.58734404
29MP0000013_abnormal_adipose_tissue1.58345155
30MP0002064_seizures1.58279649
31MP0004036_abnormal_muscle_relaxation1.57519698
32MP0002118_abnormal_lipid_homeostasis1.57425551
33MP0004147_increased_porphyrin_level1.54279401
34MP0002572_abnormal_emotion/affect_behav1.52460800
35MP0005248_abnormal_Harderian_gland1.49006422
36MP0005646_abnormal_pituitary_gland1.45900991
37MP0005083_abnormal_biliary_tract1.43991875
38MP0004019_abnormal_vitamin_homeostasis1.40207095
39MP0002876_abnormal_thyroid_physiology1.38760170
40MP0004084_abnormal_cardiac_muscle1.38368818
41MP0000920_abnormal_myelination1.37334006
42MP0010352_gastrointestinal_tract_polyps1.35686804
43MP0001486_abnormal_startle_reflex1.33494616
44MP0000609_abnormal_liver_physiology1.32040279
45MP0000604_amyloidosis1.31153429
46MP0002909_abnormal_adrenal_gland1.30806989
47MP0001968_abnormal_touch/_nociception1.29801593
48MP0002877_abnormal_melanocyte_morpholog1.29019527
49MP0003329_amyloid_beta_deposits1.28285076
50MP0004130_abnormal_muscle_cell1.27978235
51MP0004043_abnormal_pH_regulation1.26344078
52MP0003633_abnormal_nervous_system1.25592388
53MP0002734_abnormal_mechanical_nocicepti1.23648171
54MP0004145_abnormal_muscle_electrophysio1.23503348
55MP0010386_abnormal_urinary_bladder1.22820617
56MP0003690_abnormal_glial_cell1.20811428
57MP0001177_atelectasis1.19905461
58MP0003787_abnormal_imprinting1.19084764
59MP0002138_abnormal_hepatobiliary_system1.18047532
60MP0003183_abnormal_peptide_metabolism1.17110373
61MP0006276_abnormal_autonomic_nervous1.16274130
62MP0000751_myopathy1.15775737
63MP0003705_abnormal_hypodermis_morpholog1.15231645
64MP0003806_abnormal_nucleotide_metabolis1.14461257
65MP0002735_abnormal_chemical_nociception1.12033823
66MP0003890_abnormal_embryonic-extraembry1.09924104
67MP0002229_neurodegeneration1.09779400
68MP0002184_abnormal_innervation1.09242035
69MP0001501_abnormal_sleep_pattern1.08256493
70MP0002822_catalepsy1.05870519
71MP0009697_abnormal_copulation1.05833216
72MP0005386_behavior/neurological_phenoty1.05728825
73MP0004924_abnormal_behavior1.05728825
74MP0003300_gastrointestinal_ulcer1.05354740
75MP0000749_muscle_degeneration1.05304679
76MP0003172_abnormal_lysosome_physiology1.04919047
77MP0003634_abnormal_glial_cell1.04538621
78MP0001440_abnormal_grooming_behavior1.03380923
79MP0004811_abnormal_neuron_physiology1.01935911
80MP0004858_abnormal_nervous_system1.01538078
81MP0002078_abnormal_glucose_homeostasis0.98867761
82MP0000747_muscle_weakness0.98820676
83MP0002882_abnormal_neuron_morphology0.98698726
84MP0003631_nervous_system_phenotype0.97511827
85MP0004233_abnormal_muscle_weight0.97130788
86MP0003950_abnormal_plasma_membrane0.96813757
87MP0000778_abnormal_nervous_system0.96732342
88MP0002272_abnormal_nervous_system0.95598556
89MP0001970_abnormal_pain_threshold0.94671085
90MP0003879_abnormal_hair_cell0.94374491
91MP0002557_abnormal_social/conspecific_i0.93381284
92MP0002332_abnormal_exercise_endurance0.92659206
93MP0005535_abnormal_body_temperature0.92553487
94MP0005187_abnormal_penis_morphology0.91339327
95MP0010678_abnormal_skin_adnexa0.90941605
96MP0005319_abnormal_enzyme/_coenzyme0.90020703
97MP0009840_abnormal_foam_cell0.89060085
98MP0002067_abnormal_sensory_capabilities0.87890780
99MP0003656_abnormal_erythrocyte_physiolo0.87504007
100MP0003045_fibrosis0.87303289
101MP0001984_abnormal_olfaction0.85354038
102MP0002269_muscular_atrophy0.84846324
103MP0004264_abnormal_extraembryonic_tissu0.83264325
104MP0004134_abnormal_chest_morphology0.82807529
105MP0005584_abnormal_enzyme/coenzyme_acti0.82444868
106MP0002736_abnormal_nociception_after0.82090860
107MP0005620_abnormal_muscle_contractility0.81105306
108MP0000427_abnormal_hair_cycle0.80225179
109MP0005448_abnormal_energy_balance0.79130256
110MP0004085_abnormal_heartbeat0.78864529
111MP0002638_abnormal_pupillary_reflex0.78206789
112MP0001661_extended_life_span0.77839430
113MP0001756_abnormal_urination0.77723892
114MP0000003_abnormal_adipose_tissue0.77486556
115MP0005076_abnormal_cell_differentiation0.76613002
116MP0005647_abnormal_sex_gland0.76519374
117MP0002733_abnormal_thermal_nociception0.74158322
118MP0001299_abnormal_eye_distance/0.73885575
119MP0003632_abnormal_nervous_system0.72828692
120MP0000759_abnormal_skeletal_muscle0.72565476
121MP0002090_abnormal_vision0.71009324
122MP0005551_abnormal_eye_electrophysiolog0.70924739
123MP0000639_abnormal_adrenal_gland0.69895377
124MP0002069_abnormal_eating/drinking_beha0.69673431
125MP0005334_abnormal_fat_pad0.69085059
126MP0004087_abnormal_muscle_fiber0.68999785
127MP0005623_abnormal_meninges_morphology0.68193969
128MP0001764_abnormal_homeostasis0.68099938
129MP0003075_altered_response_to0.66585000
130MP0001502_abnormal_circadian_rhythm0.65941417
131MP0008874_decreased_physiological_sensi0.65123090
132MP0005645_abnormal_hypothalamus_physiol0.64294575
133MP0004885_abnormal_endolymph0.64085139
134MP0002896_abnormal_bone_mineralization0.63210310
135MP0003953_abnormal_hormone_level0.62520401
136MP0002066_abnormal_motor_capabilities/c0.60909101
137MP0002168_other_aberrant_phenotype0.60735554
138MP0002928_abnormal_bile_duct0.60338264
139MP0000955_abnormal_spinal_cord0.60221250
140MP0001324_abnormal_eye_pigmentation0.60018356
141MP0002971_abnormal_brown_adipose0.59879040
142MP0001765_abnormal_ion_homeostasis0.58747264
143MP0000579_abnormal_nail_morphology0.56939408

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)4.70461510
2Deep venous thrombosis (HP:0002625)4.45944807
3Epidermoid cyst (HP:0200040)4.20204145
4Hypobetalipoproteinemia (HP:0003563)4.08228275
5Prolonged partial thromboplastin time (HP:0003645)4.05233765
6Xanthomatosis (HP:0000991)3.91359852
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.68358166
8Complement deficiency (HP:0004431)3.64051466
9Focal motor seizures (HP:0011153)3.56165102
10Hyperventilation (HP:0002883)3.47277067
11Abnormality of aromatic amino acid family metabolism (HP:0004338)3.29486913
12Conjugated hyperbilirubinemia (HP:0002908)3.17878257
13Abnormality of the common coagulation pathway (HP:0010990)3.10225477
14Truncal ataxia (HP:0002078)3.05181213
15Abnormality of glutamine family amino acid metabolism (HP:0010902)3.03725604
16Hypolipoproteinemia (HP:0010981)3.01115225
17Impaired vibration sensation in the lower limbs (HP:0002166)2.94429940
18Pheochromocytoma (HP:0002666)2.93561396
19Focal seizures (HP:0007359)2.91600614
20Hypochromic microcytic anemia (HP:0004840)2.89119846
21Hyperlipoproteinemia (HP:0010980)2.83248007
22Bundle branch block (HP:0011710)2.82659649
23Fat malabsorption (HP:0002630)2.77479953
24Excessive salivation (HP:0003781)2.76117479
25Drooling (HP:0002307)2.76117479
26Abnormality of sulfur amino acid metabolism (HP:0004339)2.73972429
27Ankle clonus (HP:0011448)2.72519708
28Acanthocytosis (HP:0001927)2.71894358
29Fetal akinesia sequence (HP:0001989)2.69141933
30Abnormality of the intrinsic pathway (HP:0010989)2.66257105
31Joint hemorrhage (HP:0005261)2.64925936
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.64167488
33Epileptic encephalopathy (HP:0200134)2.61741223
34Urinary bladder sphincter dysfunction (HP:0002839)2.60937489
35Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.59845919
36Degeneration of the lateral corticospinal tracts (HP:0002314)2.59845919
37Hypoalphalipoproteinemia (HP:0003233)2.53268635
38Thyroid carcinoma (HP:0002890)2.51029093
39Neuroendocrine neoplasm (HP:0100634)2.49727797
40Ketosis (HP:0001946)2.48180704
41Fair hair (HP:0002286)2.46816529
42Skin nodule (HP:0200036)2.46656261
43Generalized hypopigmentation of hair (HP:0011358)2.45124457
44Lower limb muscle weakness (HP:0007340)2.44610544
45Exercise-induced muscle cramps (HP:0003710)2.42503688
46Epileptiform EEG discharges (HP:0011182)2.42316191
47Abnormal social behavior (HP:0012433)2.41561174
48Impaired social interactions (HP:0000735)2.41561174
49Status epilepticus (HP:0002133)2.40795369
50Hypercholesterolemia (HP:0003124)2.39139884
51Syncope (HP:0001279)2.37218587
52Sensorimotor neuropathy (HP:0007141)2.36538134
53Blue irides (HP:0000635)2.36172179
54Chronic hepatic failure (HP:0100626)2.35157026
55Scanning speech (HP:0002168)2.34734494
56Supranuclear gaze palsy (HP:0000605)2.34587663
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33315460
58Akinesia (HP:0002304)2.33073342
59Dysmetria (HP:0001310)2.31290759
60Impaired vibratory sensation (HP:0002495)2.31232820
61Hypoglycemic seizures (HP:0002173)2.30708203
62Abnormality of the lower motor neuron (HP:0002366)2.30374701
63Autoamputation (HP:0001218)2.30031571
64Abnormality of complement system (HP:0005339)2.29565281
65Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.28747213
66Hemiparesis (HP:0001269)2.26418946
67EEG with generalized epileptiform discharges (HP:0011198)2.26292406
68Abnormality of methionine metabolism (HP:0010901)2.25889385
69Absence seizures (HP:0002121)2.25174733
70Ventricular fibrillation (HP:0001663)2.24546136
71Hyperglycinemia (HP:0002154)2.23373630
72Hypsarrhythmia (HP:0002521)2.22583820
73Postural tremor (HP:0002174)2.21976189
74Progressive cerebellar ataxia (HP:0002073)2.20028613
75Generalized tonic-clonic seizures (HP:0002069)2.18517771
76Febrile seizures (HP:0002373)2.16996338
77Neurofibrillary tangles (HP:0002185)2.16068787
78Action tremor (HP:0002345)2.14124841
79Sudden death (HP:0001699)2.14084401
80Insulin-resistant diabetes mellitus (HP:0000831)2.13993353
81Hyperinsulinemic hypoglycemia (HP:0000825)2.13949751
82Papilledema (HP:0001085)2.13081291
83Termporal pattern (HP:0011008)2.13053771
84Insidious onset (HP:0003587)2.13053771
85Atonic seizures (HP:0010819)2.12148445
86Poor eye contact (HP:0000817)2.11601475
87Myokymia (HP:0002411)2.10782712
88Postural instability (HP:0002172)2.10660281
89Hepatocellular carcinoma (HP:0001402)2.10050416
90Upper motor neuron abnormality (HP:0002127)2.09906922
91Hyperammonemia (HP:0001987)2.09298208
92Spontaneous abortion (HP:0005268)2.09069260
93Generalized myoclonic seizures (HP:0002123)2.08101513
94Depression (HP:0000716)2.05804491
95Myocardial infarction (HP:0001658)2.05490743
96Ketoacidosis (HP:0001993)2.05417520
97Hyporeflexia of lower limbs (HP:0002600)2.03701297
98Macroorchidism (HP:0000053)2.02470740
99Tetraplegia (HP:0002445)2.01443329
100Mitral stenosis (HP:0001718)2.01128718
101Papillary thyroid carcinoma (HP:0002895)2.00574117
102Hyperglycemia (HP:0003074)2.00424557
103Abnormality of the corticospinal tract (HP:0002492)2.00203663
104Increased circulating renin level (HP:0000848)2.00015865
105Dialeptic seizures (HP:0011146)1.99858395
106Short chin (HP:0000331)1.98963812
107Arterial tortuosity (HP:0005116)1.98851644
108Hypoglycemic coma (HP:0001325)1.98695994
109Gait ataxia (HP:0002066)1.97408585
110Dysmetric saccades (HP:0000641)1.96810799
111Cerebral inclusion bodies (HP:0100314)1.96698645
112Urinary urgency (HP:0000012)1.95943475
113Dysdiadochokinesis (HP:0002075)1.95405994
114Broad-based gait (HP:0002136)1.95049378
115Subacute progressive viral hepatitis (HP:0006572)1.93951505
116Abnormality of purine metabolism (HP:0004352)1.93256751
117Calf muscle hypertrophy (HP:0008981)1.92887686
118Clonus (HP:0002169)1.89836582
119Absent speech (HP:0001344)1.89345184
120Nemaline bodies (HP:0003798)1.86423447
121Turricephaly (HP:0000262)1.86304591
122Abnormality of saccadic eye movements (HP:0000570)1.86179910
123Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.85873795
124Genetic anticipation (HP:0003743)1.85627370
125Exercise-induced myalgia (HP:0003738)1.84417457
126Overgrowth (HP:0001548)1.84035741
127Amyotrophic lateral sclerosis (HP:0007354)1.83625182
128Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82201240
129Tetraparesis (HP:0002273)1.80998804
130Gaze-evoked nystagmus (HP:0000640)1.80934755
131Gout (HP:0001997)1.80076407
132Protruding tongue (HP:0010808)1.79191187
133Hemiplegia (HP:0002301)1.78882540
134Relative macrocephaly (HP:0004482)1.78087781
135Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.77669518
136Spastic gait (HP:0002064)1.77479069
137Abnormality of ocular smooth pursuit (HP:0000617)1.77140839
138Visual hallucinations (HP:0002367)1.76453649
139Diminished movement (HP:0002374)1.76411530
140Muscle fiber inclusion bodies (HP:0100299)1.76200615
141Mutism (HP:0002300)1.75674531
142Widely spaced teeth (HP:0000687)1.75651431
143Enlarged kidneys (HP:0000105)1.74737450
144Abnormality of nucleobase metabolism (HP:0010932)1.73532894
145Abnormality of the ischium (HP:0003174)1.72281721
146Cortical dysplasia (HP:0002539)1.70925918
147Vascular calcification (HP:0004934)1.69947828
148Abnormality of serine family amino acid metabolism (HP:0010894)1.69603987
149Abnormality of glycine metabolism (HP:0010895)1.69603987
150Hepatoblastoma (HP:0002884)1.68603355
151Paraplegia (HP:0010550)1.66029873
152Abnormality of salivation (HP:0100755)1.65562886
153Intention tremor (HP:0002080)1.65235814
154Potter facies (HP:0002009)1.64168304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.46221705
2NTRK33.35575899
3FRK3.34813446
4MAP3K43.00540023
5CASK2.81055742
6MARK12.37104919
7MAP3K92.34955121
8AKT32.23616705
9MAP2K72.19561201
10LATS12.18960974
11INSRR2.18452836
12MAP2K42.18409315
13DAPK22.10349651
14MAP3K22.01487243
15SGK21.92572254
16SIK11.77842923
17OBSCN1.76848601
18SGK31.72494829
19ERBB31.68907766
20PLK21.66806696
21SCYL21.60532710
22ERBB41.58486620
23PNCK1.51423677
24RIPK41.49512112
25MINK11.47349635
26CAMK1G1.45991679
27CAMKK11.44263356
28FGFR21.44194968
29BMPR21.43691679
30PHKG11.43543989
31PHKG21.43543989
32CAMK1D1.42059658
33SGK2231.38554783
34SGK4941.38554783
35TAOK31.28100255
36PAK61.22880554
37DAPK11.20748481
38TRPM71.18955144
39NEK91.11625899
40MAPK121.10750793
41KSR11.10312787
42NEK61.10044522
43PINK11.09845939
44NTRK11.09071767
45CAMKK21.06773483
46LATS21.04972149
47STK381.02724399
48FGFR31.02052433
49OXSR11.01838723
50RET1.00757380
51PRKD30.98305134
52WNK10.95597489
53NTRK20.94807650
54PRKCG0.92854779
55SGK10.92420991
56CDK50.90966885
57KSR20.89532820
58BRD40.87833910
59PRKCH0.84816326
60UHMK10.81917694
61IRAK20.81742842
62RAF10.80350595
63WNK30.79860261
64JAK10.79741420
65FER0.79546295
66FGFR40.79057247
67YES10.78826994
68PDK10.76745565
69EEF2K0.74967771
70PTK20.72864768
71MAP3K70.72834200
72MAP4K20.72833211
73CAMK2A0.71739266
74RIPK10.71438560
75CAMK2G0.71339018
76CAMK2D0.68324420
77NUAK10.68314807
78PDPK10.67981278
79PAK30.67910292
80STK110.66188329
81PIK3CG0.66067854
82PDK40.65778454
83PDK30.65778454
84CDK120.65148743
85MET0.65083052
86PDGFRA0.64933617
87MST1R0.62906626
88PDK20.62338609
89PRKCZ0.61794088
90MAPK130.60755907
91RPS6KB10.60721532
92PRKAA10.60486614
93MUSK0.60318057
94MAP3K10.60248792
95STK240.59978890
96CAMK10.58796838
97EPHA30.58650787
98PIK3CA0.57868045
99PDGFRB0.56984836
100FGFR10.54449734
101DMPK0.54029572
102NEK10.53856851
103RPS6KA30.52850922
104PRKG10.52513047
105IRAK10.51120591
106STK390.50628306
107RPS6KA20.50287410
108PRPF4B0.49805243
109SIK30.49770678
110MAP2K10.49079291
111CSNK1G20.48976203
112JAK20.47028951
113CSNK1A1L0.46999972
114STK30.46241858
115GRK50.45118852
116CAMK2B0.45046174
117PRKAA20.44618282
118MARK20.44300224
119SIK20.43993781
120CAMK40.43686312
121PTK60.43195267
122PRKCQ0.42141743
123PRKCE0.39942585
124MAPK100.38041809
125CCNB10.37899376
126PRKCB0.37820340
127PRKACG0.34449867
128FYN0.33985528
129MAP3K120.33853057
130STK38L0.33791711
131MAPK70.33172969
132BCR0.33050240
133PTK2B0.32902069

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.86965955
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.21254931
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.87592211
4Arginine biosynthesis_Homo sapiens_hsa002202.63755056
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.11274340
6Complement and coagulation cascades_Homo sapiens_hsa046101.83741914
7Tryptophan metabolism_Homo sapiens_hsa003801.81861353
8Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.81635464
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.69807297
10Butanoate metabolism_Homo sapiens_hsa006501.69586315
11Bile secretion_Homo sapiens_hsa049761.68828583
12Circadian rhythm_Homo sapiens_hsa047101.67530501
13Nicotine addiction_Homo sapiens_hsa050331.60543299
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58171803
15Fatty acid degradation_Homo sapiens_hsa000711.55274757
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53584739
17Synaptic vesicle cycle_Homo sapiens_hsa047211.38752719
18PPAR signaling pathway_Homo sapiens_hsa033201.29901681
19Fatty acid metabolism_Homo sapiens_hsa012121.24991056
20Type II diabetes mellitus_Homo sapiens_hsa049301.21407752
21Long-term potentiation_Homo sapiens_hsa047201.20035858
22cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17548036
23Peroxisome_Homo sapiens_hsa041461.16739726
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16473978
25Amphetamine addiction_Homo sapiens_hsa050311.13444549
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11896679
27GABAergic synapse_Homo sapiens_hsa047271.10837057
28Pancreatic secretion_Homo sapiens_hsa049721.10717785
29ABC transporters_Homo sapiens_hsa020101.09508290
30Staphylococcus aureus infection_Homo sapiens_hsa051501.09485282
31Insulin secretion_Homo sapiens_hsa049111.09169747
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08223872
33Circadian entrainment_Homo sapiens_hsa047131.06659580
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04132449
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03280226
36Sulfur metabolism_Homo sapiens_hsa009201.03095595
37Inositol phosphate metabolism_Homo sapiens_hsa005621.01888565
38Propanoate metabolism_Homo sapiens_hsa006401.01211722
39Gap junction_Homo sapiens_hsa045401.00765782
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00246950
41Steroid hormone biosynthesis_Homo sapiens_hsa001400.98715972
42Glutamatergic synapse_Homo sapiens_hsa047240.98072098
43Fatty acid biosynthesis_Homo sapiens_hsa000610.96779243
44Starch and sucrose metabolism_Homo sapiens_hsa005000.96442987
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95470055
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.93456795
47Dilated cardiomyopathy_Homo sapiens_hsa054140.93451690
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93114617
49Serotonergic synapse_Homo sapiens_hsa047260.91535754
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90883919
51Salivary secretion_Homo sapiens_hsa049700.89377790
52Morphine addiction_Homo sapiens_hsa050320.89228419
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89038459
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85489013
55Olfactory transduction_Homo sapiens_hsa047400.83650279
56Vibrio cholerae infection_Homo sapiens_hsa051100.83558992
57Oocyte meiosis_Homo sapiens_hsa041140.83366766
58Dopaminergic synapse_Homo sapiens_hsa047280.83361467
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82301409
60Selenocompound metabolism_Homo sapiens_hsa004500.82294571
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82080602
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81611100
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80556770
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78861099
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78733468
66Lysine degradation_Homo sapiens_hsa003100.78633687
67beta-Alanine metabolism_Homo sapiens_hsa004100.77651346
68Renal cell carcinoma_Homo sapiens_hsa052110.77588565
69Mineral absorption_Homo sapiens_hsa049780.76315048
70Choline metabolism in cancer_Homo sapiens_hsa052310.76177206
71Histidine metabolism_Homo sapiens_hsa003400.75502784
72Pyruvate metabolism_Homo sapiens_hsa006200.75306438
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.72913836
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72779749
75Renin secretion_Homo sapiens_hsa049240.72642372
76Chemical carcinogenesis_Homo sapiens_hsa052040.71655017
77Glucagon signaling pathway_Homo sapiens_hsa049220.70373186
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.69780517
79Phenylalanine metabolism_Homo sapiens_hsa003600.69078306
80Retinol metabolism_Homo sapiens_hsa008300.68626246
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.68516012
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68191962
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67808163
84Prolactin signaling pathway_Homo sapiens_hsa049170.67568997
85AMPK signaling pathway_Homo sapiens_hsa041520.67522934
86Cholinergic synapse_Homo sapiens_hsa047250.67245398
87Prion diseases_Homo sapiens_hsa050200.66273140
88Glycerolipid metabolism_Homo sapiens_hsa005610.65915581
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64609169
90Fat digestion and absorption_Homo sapiens_hsa049750.64427157
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.64168740
92Thyroid hormone synthesis_Homo sapiens_hsa049180.64081863
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63264869
94Glioma_Homo sapiens_hsa052140.61628610
95Cocaine addiction_Homo sapiens_hsa050300.61396828
96Vitamin digestion and absorption_Homo sapiens_hsa049770.61101576
97Sphingolipid metabolism_Homo sapiens_hsa006000.61042337
98Taste transduction_Homo sapiens_hsa047420.60985624
99Insulin resistance_Homo sapiens_hsa049310.59815130
100Tyrosine metabolism_Homo sapiens_hsa003500.59725451
101Gastric acid secretion_Homo sapiens_hsa049710.59555872
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58826377
103Steroid biosynthesis_Homo sapiens_hsa001000.58817491
104Non-small cell lung cancer_Homo sapiens_hsa052230.58208063
105FoxO signaling pathway_Homo sapiens_hsa040680.57501278
106ErbB signaling pathway_Homo sapiens_hsa040120.56344294
107Long-term depression_Homo sapiens_hsa047300.54830415
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54320430
109Estrogen signaling pathway_Homo sapiens_hsa049150.53751939
110Dorso-ventral axis formation_Homo sapiens_hsa043200.52347188
111Collecting duct acid secretion_Homo sapiens_hsa049660.51308331
112mTOR signaling pathway_Homo sapiens_hsa041500.50751935
113cAMP signaling pathway_Homo sapiens_hsa040240.50259647
114Caffeine metabolism_Homo sapiens_hsa002320.48919431
115Oxytocin signaling pathway_Homo sapiens_hsa049210.48103581
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.47569719
117GnRH signaling pathway_Homo sapiens_hsa049120.45237090
118Ras signaling pathway_Homo sapiens_hsa040140.44840579
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44466077
120Insulin signaling pathway_Homo sapiens_hsa049100.43546282
121Melanogenesis_Homo sapiens_hsa049160.43538415
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43067428
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40524562
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39783270
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.39613552
126Calcium signaling pathway_Homo sapiens_hsa040200.39027057
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37644391
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.37534262
129Endometrial cancer_Homo sapiens_hsa052130.37248243
130Vitamin B6 metabolism_Homo sapiens_hsa007500.36307584
131Biosynthesis of amino acids_Homo sapiens_hsa012300.35724091
132Axon guidance_Homo sapiens_hsa043600.35494770
133Ovarian steroidogenesis_Homo sapiens_hsa049130.35247958
134MAPK signaling pathway_Homo sapiens_hsa040100.35171873
135VEGF signaling pathway_Homo sapiens_hsa043700.33486340

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