LMF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene resides in the endoplasmic reticulum, and is involved in the maturation and transport of lipoprotein lipase through the secretory pathway. Mutations in this gene are associated with combined lipase deficiency. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.52608506
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.52608506
3L-phenylalanine metabolic process (GO:0006558)6.14794346
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.14794346
5aromatic amino acid family catabolic process (GO:0009074)5.76753832
6tryptophan catabolic process (GO:0006569)5.09608060
7indole-containing compound catabolic process (GO:0042436)5.09608060
8indolalkylamine catabolic process (GO:0046218)5.09608060
9bile acid biosynthetic process (GO:0006699)4.82848984
10tryptophan metabolic process (GO:0006568)4.77058603
11glyoxylate metabolic process (GO:0046487)4.75520221
12fatty acid elongation (GO:0030497)4.64162147
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.55453549
14kynurenine metabolic process (GO:0070189)4.51770594
15mannose metabolic process (GO:0006013)4.31539795
16coenzyme catabolic process (GO:0009109)4.21282548
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.20573783
18protein carboxylation (GO:0018214)4.19193711
19peptidyl-glutamic acid carboxylation (GO:0017187)4.19193711
20alpha-linolenic acid metabolic process (GO:0036109)4.13996523
21aromatic amino acid family metabolic process (GO:0009072)4.12708656
22high-density lipoprotein particle remodeling (GO:0034375)4.09911513
23bile acid metabolic process (GO:0008206)4.09359282
24cellular biogenic amine catabolic process (GO:0042402)4.06471389
25amine catabolic process (GO:0009310)4.06471389
26urea metabolic process (GO:0019627)3.96425590
27urea cycle (GO:0000050)3.96425590
28sulfur amino acid catabolic process (GO:0000098)3.94310483
29regulation of cholesterol esterification (GO:0010872)3.92334466
30aldehyde catabolic process (GO:0046185)3.91398625
31tyrosine metabolic process (GO:0006570)3.90758585
32regulation of triglyceride catabolic process (GO:0010896)3.79475776
33nitrogen cycle metabolic process (GO:0071941)3.79250586
34low-density lipoprotein particle remodeling (GO:0034374)3.77402449
35cofactor catabolic process (GO:0051187)3.76694076
36complement activation, alternative pathway (GO:0006957)3.75265667
37axon ensheathment in central nervous system (GO:0032291)3.73950033
38central nervous system myelination (GO:0022010)3.73950033
39plasma lipoprotein particle remodeling (GO:0034369)3.72870307
40protein-lipid complex remodeling (GO:0034368)3.72870307
41macromolecular complex remodeling (GO:0034367)3.72870307
42negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.72762030
43alpha-amino acid catabolic process (GO:1901606)3.65680617
44cellular ketone body metabolic process (GO:0046950)3.65535650
45short-chain fatty acid metabolic process (GO:0046459)3.65530966
46very long-chain fatty acid metabolic process (GO:0000038)3.63771486
47regulation of fibrinolysis (GO:0051917)3.63248043
48reverse cholesterol transport (GO:0043691)3.63172663
49indolalkylamine metabolic process (GO:0006586)3.61550159
50regulation of protein activation cascade (GO:2000257)3.59508591
51cysteine metabolic process (GO:0006534)3.55862955
52amino-acid betaine metabolic process (GO:0006577)3.55184362
53cholesterol biosynthetic process (GO:0006695)3.49984614
54negative regulation of fibrinolysis (GO:0051918)3.48640018
55acetyl-CoA metabolic process (GO:0006084)3.47709795
56homocysteine metabolic process (GO:0050667)3.46415444
57nucleotide transmembrane transport (GO:1901679)3.42382019
58triglyceride homeostasis (GO:0070328)3.40531295
59acylglycerol homeostasis (GO:0055090)3.40531295
60cellular amino acid catabolic process (GO:0009063)3.40026413
61* plasma lipoprotein particle clearance (GO:0034381)3.38911858
62fatty acid beta-oxidation (GO:0006635)3.38641620
63cholesterol efflux (GO:0033344)3.37159881
64phospholipid efflux (GO:0033700)3.35732312
65NAD biosynthetic process (GO:0009435)3.34888792
66regulation of complement activation (GO:0030449)3.34387223
67opsonization (GO:0008228)3.30196214
68fatty acid catabolic process (GO:0009062)3.28526527
69regulation of ARF GTPase activity (GO:0032312)3.28260965
70monocarboxylic acid catabolic process (GO:0072329)3.23780870
71branched-chain amino acid catabolic process (GO:0009083)3.23259430
72organic acid catabolic process (GO:0016054)3.22569128
73carboxylic acid catabolic process (GO:0046395)3.22569128
74valine metabolic process (GO:0006573)3.22244329
75ketone body metabolic process (GO:1902224)3.21993326
76negative regulation of erythrocyte differentiation (GO:0045647)3.21951655
77fatty acid oxidation (GO:0019395)3.21061020
78negative regulation of cell size (GO:0045792)3.19909170
79lipid oxidation (GO:0034440)3.19229700
80chondroitin sulfate catabolic process (GO:0030207)3.18016770
81cellular modified amino acid catabolic process (GO:0042219)3.15720982
82endothelial cell chemotaxis (GO:0035767)3.15617932
83negative regulation of lipase activity (GO:0060192)3.15596100
84acyl-CoA metabolic process (GO:0006637)3.11139973
85thioester metabolic process (GO:0035383)3.11139973
86nicotinamide nucleotide biosynthetic process (GO:0019359)3.09591395
87pyridine nucleotide biosynthetic process (GO:0019363)3.09591395
88fatty-acyl-CoA biosynthetic process (GO:0046949)3.09295640
89aspartate family amino acid catabolic process (GO:0009068)3.09057729
90sterol biosynthetic process (GO:0016126)3.07921413
91bile acid and bile salt transport (GO:0015721)3.07351811
92serine family amino acid catabolic process (GO:0009071)3.05611316
93very-low-density lipoprotein particle assembly (GO:0034379)3.03771266
94negative regulation of sterol transport (GO:0032372)3.03511223
95negative regulation of cholesterol transport (GO:0032375)3.03511223
96ethanol oxidation (GO:0006069)3.03009975
97blood coagulation, intrinsic pathway (GO:0007597)3.01921032
98serine family amino acid biosynthetic process (GO:0009070)3.01022928
99positive regulation of cellular amine metabolic process (GO:0033240)3.00462599
100protein activation cascade (GO:0072376)2.99531320
101synaptic vesicle exocytosis (GO:0016079)2.99241258
102negative regulation of cell killing (GO:0031342)2.98725564
103negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.98725564
104heme transport (GO:0015886)2.97902726
105negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.97031164
106complement activation, classical pathway (GO:0006958)2.96780175
107fibrinolysis (GO:0042730)2.96554598
108negative regulation of receptor activity (GO:2000272)2.95992023
109branched-chain amino acid metabolic process (GO:0009081)2.95026522
110cholesterol homeostasis (GO:0042632)2.94922231
111long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.94748109
112drug transmembrane transport (GO:0006855)2.94243793
113negative regulation of protein tyrosine kinase activity (GO:0061099)2.78946755
114positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.78804830
115regulation of ARF protein signal transduction (GO:0032012)2.69074816
116growth hormone secretion (GO:0030252)2.64982800
117phosphatidylglycerol biosynthetic process (GO:0006655)2.63635632
118negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.63206128
119positive regulation of protein kinase C signaling (GO:0090037)2.61025916
120regulation of extracellular matrix disassembly (GO:0010715)2.54292498
121regulation of cytokine production involved in inflammatory response (GO:1900015)2.53861178
122dermatan sulfate metabolic process (GO:0030205)2.45391780
123positive regulation of histone deacetylation (GO:0031065)2.45130123
124amyloid precursor protein catabolic process (GO:0042987)2.44684553
125negative regulation of granulocyte differentiation (GO:0030853)2.44662428
126cell-cell junction maintenance (GO:0045217)2.44482940
127sulfur compound catabolic process (GO:0044273)2.43627625
128peptidyl-tyrosine autophosphorylation (GO:0038083)2.42295052
129barbed-end actin filament capping (GO:0051016)2.41892361
130protein retention in ER lumen (GO:0006621)2.39796930
131regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.39336798
132chondroitin sulfate biosynthetic process (GO:0030206)2.37745605
133retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.37229018
134purine nucleotide salvage (GO:0032261)2.31832412
135positive thymic T cell selection (GO:0045059)2.31103194
136semaphorin-plexin signaling pathway (GO:0071526)2.27667468
137neuronal ion channel clustering (GO:0045161)2.25794506
138negative regulation of blood vessel endothelial cell migration (GO:0043537)2.25665008
139negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.25440268
140synaptic vesicle docking involved in exocytosis (GO:0016081)2.24929364
141tolerance induction (GO:0002507)2.24604984
142lytic vacuole organization (GO:0080171)2.22934110
143lysosome organization (GO:0007040)2.22934110
144antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.22790129
145thymic T cell selection (GO:0045061)2.21068891
146regulation of cholesterol biosynthetic process (GO:0045540)2.20840725
147synaptic vesicle endocytosis (GO:0048488)2.18359272
148adhesion of symbiont to host (GO:0044406)2.16667493
149positive regulation of gamma-delta T cell activation (GO:0046645)2.16228267
150regulation of plasminogen activation (GO:0010755)2.15009477
151establishment of mitochondrion localization (GO:0051654)2.14048960
152negative regulation of interleukin-2 production (GO:0032703)2.13904713
153cellular response to exogenous dsRNA (GO:0071360)2.13489362
154positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.13078652
155virion attachment to host cell (GO:0019062)2.12880857
156adhesion of symbiont to host cell (GO:0044650)2.12880857
157regulation of cholesterol storage (GO:0010885)2.12760042
158histone H4 deacetylation (GO:0070933)2.11697836
159regulation of hydrogen peroxide metabolic process (GO:0010310)2.11318237
160antigen processing and presentation of endogenous antigen (GO:0019883)2.10273285
161regulation of gamma-delta T cell differentiation (GO:0045586)2.09889750
162protein heterotrimerization (GO:0070208)2.09781260
163negative regulation of innate immune response (GO:0045824)2.07139006
164stress fiber assembly (GO:0043149)2.06229689
165regulation of clathrin-mediated endocytosis (GO:2000369)2.06068970
166positive regulation of receptor recycling (GO:0001921)2.05538004
167cell migration involved in heart development (GO:0060973)2.05244735
168peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.04752911
169positive regulation of cholesterol efflux (GO:0010875)2.03304650
170antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.02690265
171amyloid precursor protein metabolic process (GO:0042982)2.01870007
172regulation of histone deacetylation (GO:0031063)2.01627203
173response to magnesium ion (GO:0032026)2.01227335
174regulation of gamma-delta T cell activation (GO:0046643)2.01068350
175regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.00194127
176positive regulation of extracellular matrix organization (GO:1903055)1.99632703
177behavioral response to pain (GO:0048266)1.99295907
178extracellular matrix assembly (GO:0085029)1.99196947
179response to muramyl dipeptide (GO:0032495)1.98931624
180regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.98580463
181layer formation in cerebral cortex (GO:0021819)1.98002939
182activation of JUN kinase activity (GO:0007257)1.96240114
183vacuole organization (GO:0007033)1.94873654
184regulation of amyloid precursor protein catabolic process (GO:1902991)1.92457713
185* regulation of cholesterol metabolic process (GO:0090181)1.92228234
186ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043161.91943619
187negative regulation of synaptic transmission, GABAergic (GO:0032229)1.91309130
188glial cell migration (GO:0008347)1.90723069
189response to manganese ion (GO:0010042)1.90469629
190deoxyribonucleotide catabolic process (GO:0009264)1.88996201
191T cell selection (GO:0045058)1.88295010
192negative regulation of myotube differentiation (GO:0010832)1.88152854
193positive regulation of endothelial cell differentiation (GO:0045603)1.88092808
194snRNA transcription (GO:0009301)1.88067992
195maintenance of protein localization in endoplasmic reticulum (GO:0035437)1.87933067
196response to methylmercury (GO:0051597)1.87084805
197dermatan sulfate biosynthetic process (GO:0030208)1.86702864
198autophagic vacuole assembly (GO:0000045)1.86627696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.34242550
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.16735938
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.03019855
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.37819266
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.25751969
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.91646897
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.26533960
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.18098705
9* LXR_22292898_ChIP-Seq_THP-1_Human3.05476499
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.67258766
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.61117421
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.52170491
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.51164959
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46053382
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.42329004
16VDR_21846776_ChIP-Seq_THP-1_Human2.37049957
17* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.36324680
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.18398255
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.16166205
20P68_20966046_ChIP-Seq_HELA_Human2.12717674
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05175329
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02231355
23KDM2B_26808549_Chip-Seq_DND41_Human2.01429920
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99273952
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98784785
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.92272281
27DNAJC2_21179169_ChIP-ChIP_NT2_Human1.91931506
28DROSHA_22980978_ChIP-Seq_HELA_Human1.89771076
29EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.83819282
30* SMC4_20622854_ChIP-Seq_HELA_Human1.80422448
31SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.77808719
32* KDM2B_26808549_Chip-Seq_K562_Human1.76458800
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76281162
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.74395116
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.73164781
36TCF7_22412390_ChIP-Seq_EML_Mouse1.72847213
37RACK7_27058665_Chip-Seq_MCF-7_Human1.71782474
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70107823
39HTT_18923047_ChIP-ChIP_STHdh_Human1.69732881
40BCL6_27268052_Chip-Seq_Bcells_Human1.68498668
41GBX2_23144817_ChIP-Seq_PC3_Human1.66748081
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.66470056
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.64929640
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.64864901
45CTCF_27219007_Chip-Seq_Bcells_Human1.60389860
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59830597
47SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58759107
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57670456
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56348094
50BCOR_27268052_Chip-Seq_Bcells_Human1.54897582
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52980573
52* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51111130
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43572400
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.43306437
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43168493
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42900554
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42773989
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42216782
59TAF15_26573619_Chip-Seq_HEK293_Human1.41186589
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.39161489
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38346495
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38148803
63MAF_26560356_Chip-Seq_TH2_Human1.37657082
64CREB1_26743006_Chip-Seq_LNCaP_Human1.35977667
65* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35185086
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.34824810
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34798712
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34657539
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34087712
70VDR_24763502_ChIP-Seq_THP-1_Human1.32088467
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32044949
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31064882
73PHF8_20622854_ChIP-Seq_HELA_Human1.30608262
74MYC_22102868_ChIP-Seq_BL_Human1.29966429
75TP63_22573176_ChIP-Seq_HFKS_Human1.28392274
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28058733
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.27923016
78UTX_26944678_Chip-Seq_JUKART_Human1.27542590
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24453542
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23875984
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23416529
82MAF_26560356_Chip-Seq_TH1_Human1.23365512
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23175435
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22708195
85RARB_24833708_ChIP-Seq_LIVER_Mouse1.20346316
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.19609235
87TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19350122
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.18402977
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.18087499
90* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17149768
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16847531
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.16842982
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16511454
94TET1_21490601_ChIP-Seq_MESCs_Mouse1.16052355
95* FOXA2_19822575_ChIP-Seq_HepG2_Human1.14987093
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14106665
97* E2F1_20622854_ChIP-Seq_HELA_Human1.13705652
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12573471
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.12412379
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12093566
101YY1_22570637_ChIP-Seq_MALME-3M_Human1.11897828
102CTCF_20526341_ChIP-Seq_ESCs_Human1.11831795
103TP53_22127205_ChIP-Seq_IMR90_Human1.11774788
104OCT4_19829295_ChIP-Seq_ESCs_Human1.11116026
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10872578
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10421034
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10209981
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09069402
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08939158
110MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08349899
111MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08347927
112RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07981407
113SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07604985
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07083387
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.06684896
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06197262
117PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05884659
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04887910
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04456631
120TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03965335
121SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03804899
122* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03762107
123SA1_27219007_Chip-Seq_Bcells_Human1.03679195
124BP1_19119308_ChIP-ChIP_Hs578T_Human1.02464113
125CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01027299
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00715268
127ER_23166858_ChIP-Seq_MCF-7_Human1.00000130
128RARB_27405468_Chip-Seq_BRAIN_Mouse0.99673210
129ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99434462
130EZH2_22144423_ChIP-Seq_EOC_Human0.99317711
131GATA1_22025678_ChIP-Seq_K562_Human0.99301111
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99259070
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98810218
134RUNX1_27514584_Chip-Seq_MCF-7_Human0.98303454
135ETS1_21867929_ChIP-Seq_TH2_Mouse0.98096440
136CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97928096
137SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97837483
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.97560594
139P53_22387025_ChIP-Seq_ESCs_Mouse0.97346922
140* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97219687
141IRF8_21731497_ChIP-ChIP_J774_Mouse0.95854621
142STAT3_18555785_Chip-Seq_ESCs_Mouse0.95269838
143EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94063257
144VDR_22108803_ChIP-Seq_LS180_Human0.93420542
145IRF8_27001747_Chip-Seq_BMDM_Mouse0.93416683
146P300_18555785_Chip-Seq_ESCs_Mouse0.91480498
147RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91002485
148PU1_27457419_Chip-Seq_LIVER_Mouse0.89770474
149OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89643154
150PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88259046
151* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87617944
152* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87617944
153HNF4A_19822575_ChIP-Seq_HepG2_Human0.86893934
154CBP_21632823_ChIP-Seq_H3396_Human0.86725965
155RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86418823
156SMAD1_18555785_Chip-Seq_ESCs_Mouse0.86259402
157AR_20517297_ChIP-Seq_VCAP_Human0.86239365
158CMYC_18555785_Chip-Seq_ESCs_Mouse0.85239221
159OCT4_18555785_Chip-Seq_ESCs_Mouse0.83507760
160ZFX_18555785_Chip-Seq_ESCs_Mouse0.81929153
161FLI1_27457419_Chip-Seq_LIVER_Mouse0.81293649
162PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80808187
163PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80796944
164THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80539601
165PIAS1_25552417_ChIP-Seq_VCAP_Human0.80225442
166FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79570077
167KLF4_18555785_Chip-Seq_ESCs_Mouse0.79409267
168ESRRB_18555785_Chip-Seq_ESCs_Mouse0.79331851
169STAT1_17558387_ChIP-Seq_HELA_Human0.78861990
170HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78673100
171IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.78369226
172POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77840750
173* OCT4_20526341_ChIP-Seq_ESCs_Human0.77744512
174SRF_21415370_ChIP-Seq_HL-1_Mouse0.77612703
175* KDM2B_26808549_Chip-Seq_REH_Human0.77101549
176SOX2_18555785_Chip-Seq_ESCs_Mouse0.76351890
177NANOG_18555785_Chip-Seq_ESCs_Mouse0.75834073
178VDR_24787735_ChIP-Seq_THP-1_Human0.75112682
179P300_19829295_ChIP-Seq_ESCs_Human0.74699566
180PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.72590163
181IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.71993513
182SOX2_19829295_ChIP-Seq_ESCs_Human0.71909861
183NANOG_19829295_ChIP-Seq_ESCs_Human0.71909861
184GATA2_21666600_ChIP-Seq_HMVEC_Human0.71431219
185PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.71139753
186KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70776501
187E2F1_18555785_Chip-Seq_ESCs_Mouse0.70366822
188* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.69598888
189NMYC_18555785_Chip-Seq_ESCs_Mouse0.69528330
190LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69336092
191ESET_19884257_ChIP-Seq_ESCs_Mouse0.68990715
192CTCF_18555785_Chip-Seq_ESCs_Mouse0.68806140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.48531079
2MP0005360_urolithiasis5.59882523
3MP0005085_abnormal_gallbladder_physiolo5.11226576
4MP0005365_abnormal_bile_salt5.06056335
5MP0003806_abnormal_nucleotide_metabolis4.23921807
6MP0008875_abnormal_xenobiotic_pharmacok3.89185380
7MP0003252_abnormal_bile_duct3.11296000
8MP0003195_calcinosis3.10894019
9MP0003705_abnormal_hypodermis_morpholog2.78468574
10MP0005083_abnormal_biliary_tract2.59343469
11MP0009840_abnormal_foam_cell2.52920800
12MP0003279_aneurysm2.48001069
13MP0005332_abnormal_amino_acid2.45551495
14MP0010329_abnormal_lipoprotein_level2.44726625
15MP0001958_emphysema2.42153524
16MP0004859_abnormal_synaptic_plasticity2.36046395
17MP0001666_abnormal_nutrient_absorption2.35999164
18MP0000920_abnormal_myelination2.24758038
19MP0003436_decreased_susceptibility_to2.21159869
20MP0009697_abnormal_copulation2.20971445
21MP0005451_abnormal_body_composition2.02644625
22MP0002653_abnormal_ependyma_morphology1.98484749
23* MP0002118_abnormal_lipid_homeostasis1.97874090
24MP0003690_abnormal_glial_cell1.93338968
25MP0005503_abnormal_tendon_morphology1.90406103
26MP0005670_abnormal_white_adipose1.84080223
27MP0005410_abnormal_fertilization1.83976697
28MP0008260_abnormal_autophagy1.79606091
29MP0003191_abnormal_cellular_cholesterol1.78458312
30MP0009278_abnormal_bone_marrow1.75392873
31MP0004858_abnormal_nervous_system1.70197732
32MP0004019_abnormal_vitamin_homeostasis1.65950118
33MP0003868_abnormal_feces_composition1.63471411
34MP0000751_myopathy1.63376563
35MP0003011_delayed_dark_adaptation1.59762235
36MP0006082_CNS_inflammation1.53354379
37* MP0005584_abnormal_enzyme/coenzyme_acti1.53304616
38MP0002138_abnormal_hepatobiliary_system1.52703959
39MP0000609_abnormal_liver_physiology1.52211364
40MP0003303_peritoneal_inflammation1.51166329
41MP0001849_ear_inflammation1.50253910
42MP0005058_abnormal_lysosome_morphology1.45989981
43MP0001764_abnormal_homeostasis1.42851502
44MP0005423_abnormal_somatic_nervous1.40864443
45MP0003879_abnormal_hair_cell1.40402093
46MP0005319_abnormal_enzyme/_coenzyme1.36523025
47MP0009764_decreased_sensitivity_to1.34973068
48MP0003136_yellow_coat_color1.29403510
49MP0001533_abnormal_skeleton_physiology1.28691256
50MP0004381_abnormal_hair_follicle1.23311478
51MP0003186_abnormal_redox_activity1.23073086
52MP0003724_increased_susceptibility_to1.22995717
53MP0005171_absent_coat_pigmentation1.22851450
54MP0009643_abnormal_urine_homeostasis1.21456131
55MP0004947_skin_inflammation1.16840076
56MP0000566_synostosis1.16352023
57MP0005408_hypopigmentation1.14913117
58MP0000013_abnormal_adipose_tissue1.14407273
59MP0001542_abnormal_bone_strength1.11630085
60MP0005647_abnormal_sex_gland1.10702619
61MP0008874_decreased_physiological_sensi1.09606058
62MP0002876_abnormal_thyroid_physiology1.08176111
63MP0002132_abnormal_respiratory_system1.07943907
64MP0005595_abnormal_vascular_smooth1.07918221
65MP0000767_abnormal_smooth_muscle1.06275780
66MP0005390_skeleton_phenotype1.05752195
67MP0003656_abnormal_erythrocyte_physiolo1.05019450
68MP0002249_abnormal_larynx_morphology1.04543355
69MP0001502_abnormal_circadian_rhythm1.04108441
70MP0000604_amyloidosis1.03385065
71MP0008569_lethality_at_weaning1.03179463
72MP0003635_abnormal_synaptic_transmissio1.02921254
73MP0005000_abnormal_immune_tolerance1.02838934
74MP0003763_abnormal_thymus_physiology1.02741184
75MP0003091_abnormal_cell_migration1.02392502
76MP0003300_gastrointestinal_ulcer0.99753365
77MP0009763_increased_sensitivity_to0.99496865
78MP0008469_abnormal_protein_level0.98694488
79MP0000003_abnormal_adipose_tissue0.98509888
80MP0002063_abnormal_learning/memory/cond0.97218004
81MP0000465_gastrointestinal_hemorrhage0.96940927
82MP0005636_abnormal_mineral_homeostasis0.96831853
83MP0005508_abnormal_skeleton_morphology0.94276329
84MP0003878_abnormal_ear_physiology0.94091706
85MP0005377_hearing/vestibular/ear_phenot0.94091706
86MP0002822_catalepsy0.93759153
87* MP0002295_abnormal_pulmonary_circulatio0.93723756
88MP0002998_abnormal_bone_remodeling0.91463345
89MP0002064_seizures0.90713887
90MP0002419_abnormal_innate_immunity0.88949983
91MP0006036_abnormal_mitochondrial_physio0.88890789
92MP0009765_abnormal_xenobiotic_induced0.88753255
93MP0002735_abnormal_chemical_nociception0.86414466
94MP0004133_heterotaxia0.85720945
95MP0001851_eye_inflammation0.85492884
96MP0004142_abnormal_muscle_tone0.85370881
97MP0000678_abnormal_parathyroid_gland0.85279687
98MP0005275_abnormal_skin_tensile0.84491648
99MP0001800_abnormal_humoral_immune0.84319919
100MP0001661_extended_life_span0.83770160
101MP0003950_abnormal_plasma_membrane0.83703149
102MP0002723_abnormal_immune_serum0.82625570
103MP0001486_abnormal_startle_reflex0.82467235
104MP0004742_abnormal_vestibular_system0.81059911
105MP0004147_increased_porphyrin_level0.80987939
106MP0001986_abnormal_taste_sensitivity0.79179687
107MP0001873_stomach_inflammation0.77231764
108MP0005671_abnormal_response_to0.76918571
109* MP0009642_abnormal_blood_homeostasis0.76607218
110MP0000026_abnormal_inner_ear0.75555973
111MP0002108_abnormal_muscle_morphology0.75028551
112MP0003633_abnormal_nervous_system0.74405360
113MP0000733_abnormal_muscle_development0.74082418
114MP0000750_abnormal_muscle_regeneration0.74078393
115MP0004130_abnormal_muscle_cell0.73630947
116MP0000598_abnormal_liver_morphology0.72459225
117MP0002148_abnormal_hypersensitivity_rea0.72023762
118MP0004510_myositis0.71967638
119MP0004043_abnormal_pH_regulation0.71385209
120MP0000858_altered_metastatic_potential0.71370045
121MP0005535_abnormal_body_temperature0.71358625
122MP0009384_cardiac_valve_regurgitation0.70456997
123MP0005220_abnormal_exocrine_pancreas0.69944717
124MP0002572_abnormal_emotion/affect_behav0.69653170
125MP0002452_abnormal_antigen_presenting0.68772220
126MP0003329_amyloid_beta_deposits0.68754550
127MP0002089_abnormal_postnatal_growth/wei0.68446647
128MP0001270_distended_abdomen0.68387604
129MP0000747_muscle_weakness0.68256046
130MP0001963_abnormal_hearing_physiology0.67575524
131MP0005334_abnormal_fat_pad0.67197526
132MP0010368_abnormal_lymphatic_system0.66612492
133MP0005167_abnormal_blood-brain_barrier0.66508340
134MP0005084_abnormal_gallbladder_morpholo0.65780081
135MP0002420_abnormal_adaptive_immunity0.65439035
136MP0001819_abnormal_immune_cell0.65305131
137MP0002405_respiratory_system_inflammati0.64797489
138MP0005025_abnormal_response_to0.64439861
139MP0005379_endocrine/exocrine_gland_phen0.64051489
140MP0001835_abnormal_antigen_presentation0.63836878
141MP0005376_homeostasis/metabolism_phenot0.63578494
142MP0009785_altered_susceptibility_to0.63365517
143MP0005075_abnormal_melanosome_morpholog0.63201991
144MP0005646_abnormal_pituitary_gland0.62936914
145MP0002078_abnormal_glucose_homeostasis0.61953279
146MP0000749_muscle_degeneration0.61817244
147MP0002933_joint_inflammation0.60258873
148MP0005666_abnormal_adipose_tissue0.59615956
149MP0000372_irregular_coat_pigmentation0.59502978
150MP0003634_abnormal_glial_cell0.57679055
151MP0001905_abnormal_dopamine_level0.56069228
152MP0003172_abnormal_lysosome_physiology0.55930286
153MP0000230_abnormal_systemic_arterial0.55353658
154MP0001765_abnormal_ion_homeostasis0.54757752
155MP0000639_abnormal_adrenal_gland0.54499721
156MP0002229_neurodegeneration0.53680995
157MP0002971_abnormal_brown_adipose0.53535099
158MP0004782_abnormal_surfactant_physiolog0.53206566
159MP0004134_abnormal_chest_morphology0.52892819
160MP0005464_abnormal_platelet_physiology0.52707284
161MP0001485_abnormal_pinna_reflex0.52486264
162MP0008438_abnormal_cutaneous_collagen0.52313963
163MP0003075_altered_response_to0.51624951
164MP0005551_abnormal_eye_electrophysiolog0.51619470
165MP0003183_abnormal_peptide_metabolism0.50041145
166MP0001790_abnormal_immune_system0.49380642
167MP0005387_immune_system_phenotype0.49380642
168MP0001845_abnormal_inflammatory_respons0.49074310
169MP0001324_abnormal_eye_pigmentation0.47174398

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.81380881
2Intrahepatic cholestasis (HP:0001406)5.48596266
3Prolonged partial thromboplastin time (HP:0003645)5.35862852
4Deep venous thrombosis (HP:0002625)4.68772919
5Xanthomatosis (HP:0000991)4.46413919
6Hyperlipoproteinemia (HP:0010980)4.41866718
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.13711819
8Joint hemorrhage (HP:0005261)4.02046619
9Dysostosis multiplex (HP:0000943)3.90034897
10Hypobetalipoproteinemia (HP:0003563)3.89552785
11Abnormality of polysaccharide metabolism (HP:0011012)3.78006381
12Abnormality of glycosaminoglycan metabolism (HP:0004371)3.78006381
13Abnormality of mucopolysaccharide metabolism (HP:0011020)3.78006381
14Abnormality of methionine metabolism (HP:0010901)3.65185982
15Urinary glycosaminoglycan excretion (HP:0003541)3.58953281
16Mucopolysacchariduria (HP:0008155)3.58953281
17Complement deficiency (HP:0004431)3.58944982
18Obstructive sleep apnea (HP:0002870)3.54329384
19Abnormality of aspartate family amino acid metabolism (HP:0010899)3.50470840
20Ketosis (HP:0001946)3.39179363
21Fat malabsorption (HP:0002630)3.37510806
22Hyperammonemia (HP:0001987)3.26902188
23Conjugated hyperbilirubinemia (HP:0002908)3.22010325
24Abnormality of the intrinsic pathway (HP:0010989)3.18056979
25Abnormality of fatty-acid metabolism (HP:0004359)3.16347569
26Abnormality of glycosphingolipid metabolism (HP:0004343)3.15728104
27Abnormality of glycolipid metabolism (HP:0010969)3.15728104
28Abnormality of liposaccharide metabolism (HP:0010968)3.15728104
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.15609517
30Joint stiffness (HP:0001387)3.04627058
31Vascular calcification (HP:0004934)3.01994567
32Steatorrhea (HP:0002570)2.97817655
33Spontaneous hematomas (HP:0007420)2.95958621
34Abnormality of dicarboxylic acid metabolism (HP:0010995)2.94397779
35Dicarboxylic aciduria (HP:0003215)2.94397779
36Hypoglycemic coma (HP:0001325)2.93883661
37Abnormality of glycine metabolism (HP:0010895)2.93619458
38Abnormality of serine family amino acid metabolism (HP:0010894)2.93619458
39Abnormality of the common coagulation pathway (HP:0010990)2.92790064
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.91845894
41Hyperglycinemia (HP:0002154)2.90230779
42Protrusio acetabuli (HP:0003179)2.88140233
43Cervical subluxation (HP:0003308)2.88009935
44Epidermoid cyst (HP:0200040)2.87398646
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.85036735
46J-shaped sella turcica (HP:0002680)2.83472592
47Cerebral aneurysm (HP:0004944)2.79749043
48Abnormality of glutamine family amino acid metabolism (HP:0010902)2.79587383
49Hypolipoproteinemia (HP:0010981)2.76843135
50Stridor (HP:0010307)2.75017544
51Petechiae (HP:0000967)2.69073793
52Cerebral edema (HP:0002181)2.68848819
53Abnormality of pyrimidine metabolism (HP:0004353)2.65534422
54Abnormality of glycolysis (HP:0004366)2.65198023
55Increased serum pyruvate (HP:0003542)2.65198023
56Flared iliac wings (HP:0002869)2.64845375
57Hyperglycinuria (HP:0003108)2.64722265
58Fragile skin (HP:0001030)2.64156363
59Generalized aminoaciduria (HP:0002909)2.62470355
60Cardiovascular calcification (HP:0011915)2.62459209
61Abnormality of serum amino acid levels (HP:0003112)2.61555042
62Opisthotonus (HP:0002179)2.60615597
63Spastic paraparesis (HP:0002313)2.60291090
64Parakeratosis (HP:0001036)2.56254942
65Supranuclear gaze palsy (HP:0000605)2.52938429
66Myositis (HP:0100614)2.51918078
67Thin bony cortex (HP:0002753)2.51608298
68Biconcave vertebral bodies (HP:0004586)2.48213954
69Abnormality of complement system (HP:0005339)2.48047276
70Lymphangioma (HP:0100764)2.45106168
71Distal upper limb amyotrophy (HP:0007149)2.43285258
72Upper limb amyotrophy (HP:0009129)2.43285258
73Interstitial pulmonary disease (HP:0006530)2.42193865
74Hypercholesterolemia (HP:0003124)2.41797385
75Metabolic acidosis (HP:0001942)2.41495976
76Mitral stenosis (HP:0001718)2.39900189
77Loss of speech (HP:0002371)2.39543366
78Broad metatarsal (HP:0001783)2.39212459
79Neurofibrillary tangles (HP:0002185)2.37053039
80Visceral angiomatosis (HP:0100761)2.36600820
81Hyperacusis (HP:0010780)2.35708221
82Systemic lupus erythematosus (HP:0002725)2.35162702
83Delayed CNS myelination (HP:0002188)2.34997994
84Premature rupture of membranes (HP:0001788)2.34867613
85Eczematoid dermatitis (HP:0000976)2.34638593
86Hepatic necrosis (HP:0002605)2.33997893
87Lethargy (HP:0001254)2.33989650
88Hypoalphalipoproteinemia (HP:0003233)2.33619270
89Papilledema (HP:0001085)2.33053792
90Abnormal gallbladder physiology (HP:0012438)2.31933907
91Cholecystitis (HP:0001082)2.31933907
92Hyperbilirubinemia (HP:0002904)2.31852163
93Mesangial abnormality (HP:0001966)2.29577064
94Colitis (HP:0002583)2.28543804
95Myocardial infarction (HP:0001658)2.28116516
96Renal cortical cysts (HP:0000803)2.24256713
97Ketoacidosis (HP:0001993)2.23874707
98Mitral regurgitation (HP:0001653)2.23628362
99Acute encephalopathy (HP:0006846)2.21009870
100Axonal loss (HP:0003447)2.20592467
101Abnormality of urine glucose concentration (HP:0011016)2.19666588
102Glycosuria (HP:0003076)2.19666588
103Hypoglycemic seizures (HP:0002173)2.17126920
104Disproportionate tall stature (HP:0001519)2.16101784
105Ovoid vertebral bodies (HP:0003300)2.15565910
106Paraparesis (HP:0002385)2.14950773
107Abnormal gallbladder morphology (HP:0012437)2.14814382
108Renal Fanconi syndrome (HP:0001994)2.14237923
109Amyloidosis (HP:0011034)2.13531739
110Methylmalonic acidemia (HP:0002912)2.13044111
111Increased cerebral lipofuscin (HP:0011813)2.12176012
112Vomiting (HP:0002013)2.11976160
113Neuronal loss in central nervous system (HP:0002529)2.11405147
114Recurrent gram-negative bacterial infections (HP:0005420)2.10524886
115Thoracic kyphosis (HP:0002942)2.09578257
116Abnormality of nucleobase metabolism (HP:0010932)2.07438919
117Hypoplasia of the odontoid process (HP:0003311)2.06739251
118Aortic regurgitation (HP:0001659)2.05962941
119Hypophosphatemic rickets (HP:0004912)2.05532674
120Hemangiomatosis (HP:0007461)2.04608497
121Hand muscle atrophy (HP:0009130)2.04004997
122Purpura (HP:0000979)2.03522117
123Pancreatitis (HP:0001733)2.03049387
124Vacuolated lymphocytes (HP:0001922)2.02980205
125Ankle clonus (HP:0011448)2.00230601
126Reduced antithrombin III activity (HP:0001976)1.99147522
127Annular pancreas (HP:0001734)1.99056509
128Shallow orbits (HP:0000586)1.98736935
129Gingival bleeding (HP:0000225)1.98156851
130Atelectasis (HP:0100750)1.98091390
131Broad face (HP:0000283)1.97608578
132Bladder diverticulum (HP:0000015)1.96472468
133Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96439160
134Enlarged kidneys (HP:0000105)1.95478058
135Hepatocellular necrosis (HP:0001404)1.94832003
136Spinal canal stenosis (HP:0003416)1.94558473
137Methylmalonic aciduria (HP:0012120)1.93563862
138Difficulty climbing stairs (HP:0003551)1.93528422
139Abnormality of the odontoid process (HP:0003310)1.93326536
140Increased IgE level (HP:0003212)1.92309323
141Glomerulonephritis (HP:0000099)1.91224340
142Vertebral compression fractures (HP:0002953)1.90942912
143Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.89769760
144Alkalosis (HP:0001948)1.89325764
145Elevated hepatic transaminases (HP:0002910)1.87610168
146Turricephaly (HP:0000262)1.86721955
147Easy fatigability (HP:0003388)1.85440145
148Cholelithiasis (HP:0001081)1.83261700
149Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83027325
150Degeneration of the lateral corticospinal tracts (HP:0002314)1.83027325
151Peripheral hypomyelination (HP:0007182)1.82282639
152Hepatocellular carcinoma (HP:0001402)1.81813669
153Proximal tubulopathy (HP:0000114)1.81712192
154Abnormality of the nasal mucosa (HP:0000433)1.81436270
155Deformed sella turcica (HP:0002681)1.81214517
156Pustule (HP:0200039)1.80988314
157White forelock (HP:0002211)1.80940919
158Patchy hypopigmentation of hair (HP:0011365)1.80329850
159Aneurysm (HP:0002617)1.80297528
160Anomalous pulmonary venous return (HP:0010772)1.80201367
161Mildly elevated creatine phosphokinase (HP:0008180)1.79981781
162Hemorrhage of the eye (HP:0011885)1.79412387
163Elevated alkaline phosphatase (HP:0003155)1.79029553
164Abnormality of purine metabolism (HP:0004352)1.78391167
165Genu recurvatum (HP:0002816)1.78195484
166Bulbar palsy (HP:0001283)1.77903529
167Skin nodule (HP:0200036)1.77712931
168Orchitis (HP:0100796)1.77708265
169Vitreoretinal degeneration (HP:0000655)1.76091828
170Abnormality of the gallbladder (HP:0005264)1.74936703
171Emphysema (HP:0002097)1.74054358
172Irritability (HP:0000737)1.73525940
173Abnormality of the thoracic spine (HP:0100711)1.73120986
174Nuclear cataract (HP:0100018)1.72280348
175Symptomatic seizures (HP:0011145)1.72157756
176Peritonitis (HP:0002586)1.71796999
177Short femoral neck (HP:0100864)1.70753473
178Abnormality of dentin (HP:0010299)1.70338024
179Esophageal varix (HP:0002040)1.68196734
180Broad distal phalanx of finger (HP:0009836)1.67573133
181Blue sclerae (HP:0000592)1.67281496
182Increased neuronal autofluorescent lipopigment (HP:0002074)1.67260037
183Abnormality of binocular vision (HP:0011514)1.67124312
184Diplopia (HP:0000651)1.67124312
185Pointed chin (HP:0000307)1.66716038
186Abnormal eating behavior (HP:0100738)1.66185253
187Elevated erythrocyte sedimentation rate (HP:0003565)1.65939446
188Hemoptysis (HP:0002105)1.65755150
189Hypertriglyceridemia (HP:0002155)1.65512152
190Pulmonary embolism (HP:0002204)1.64869467
191Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.64672363
192Lumbar hyperlordosis (HP:0002938)1.64118645
193Gastrointestinal inflammation (HP:0004386)1.63535381
194Ulnar bowing (HP:0003031)1.63488983
195Aortic aneurysm (HP:0004942)1.63370758
196Pulmonary artery stenosis (HP:0004415)1.63284625
197Gingivitis (HP:0000230)1.62846061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.96387296
2STK393.77291587
3TRIB33.38664259
4INSRR2.88997658
5EPHB12.88394527
6SIK22.48388797
7OXSR12.45885925
8WNK42.28796339
9MAP3K142.23379360
10TAOK32.19607496
11MAP3K112.14636730
12PKN22.12573044
13TNIK2.08927149
14PBK2.05697420
15PKN12.02273457
16ERN11.96354020
17PIK3CG1.90331931
18MAPK151.89838165
19STK161.78839420
20SIK11.75916224
21IRAK31.70341148
22GRK61.68625707
23BMPR1B1.59540786
24BCR1.58048609
25RIPK11.57751940
26MET1.56013295
27MARK21.51491307
28SMG11.50965867
29PRPF4B1.47711014
30OBSCN1.46289701
31PRKD21.45717330
32ICK1.42924748
33PRKD31.39194128
34MAP3K31.38916111
35CDC42BPA1.38863271
36MUSK1.34398912
37ZAP701.30331939
38IRAK41.30214255
39ADRBK21.29431054
40ERBB41.29051712
41DDR21.28777373
42NTRK31.26430211
43TESK11.25026531
44CASK1.20815922
45BTK1.17391987
46IKBKE1.17167782
47SGK4941.14308522
48SGK2231.14308522
49SIK31.14169960
50PRKCQ1.13809535
51NTRK21.13102767
52PINK11.11340593
53MAP3K11.09859218
54TBK11.09548091
55GRK11.09133497
56MAPKAPK51.08776200
57KIT1.08194088
58GRK71.07638565
59FGFR41.07436062
60IRAK11.05125168
61ZAK1.04511924
62TEC1.04353590
63NUAK11.03672924
64MST1R1.01506381
65DYRK1B0.99227125
66RPS6KA20.98976832
67TESK20.97592660
68PAK60.97344691
69CAMKK10.97033317
70MAP3K130.95653052
71FES0.95491570
72TXK0.93141469
73DAPK20.90387132
74CAMK2D0.89940063
75IRAK20.88359912
76ITK0.87647179
77CAMK2G0.86979105
78MYLK0.84609381
79IKBKB0.82807690
80HIPK20.80279123
81PTK60.80232748
82CAMK1G0.79180300
83TAOK10.79073524
84MAP3K60.77734875
85MAP3K70.76872428
86FGFR20.76805847
87TYK20.76151368
88PRKAA20.76054747
89RET0.75825183
90CSK0.75531406
91MAP2K20.72795585
92NTRK10.72077354
93WNK10.71682805
94PDGFRA0.70664401
95HCK0.70186144
96BMX0.69993545
97PRKCE0.68347435
98TIE10.68207660
99CDK90.68021185
100MAP4K10.67424453
101CSNK1G30.67153703
102EIF2AK20.66728035
103TAOK20.66182704
104LYN0.64426499
105CDK190.64403667
106CSF1R0.63680112
107CSNK1A1L0.63505008
108CLK10.61603652
109CAMK2B0.61529851
110CSNK1G10.60773803
111STK380.59899666
112PTK2B0.59698153
113JAK30.59653169
114BLK0.59165490
115TRPM70.58534594
116SGK20.58284041
117TGFBR20.57399273
118MAPK70.57085207
119RPS6KL10.56793174
120RPS6KC10.56793174
121TYRO30.56136448
122MAPK110.56013832
123LMTK20.55735537
124MARK10.55492698
125FGR0.54125931
126CDK50.54123116
127ABL20.53837157
128MAPK120.52489997
129SYK0.51049428
130PRKCH0.50701275
131FLT30.48553639
132NEK60.48359632
133CAMK2A0.48063820
134JAK20.47855503
135FYN0.47837254
136NEK90.47828979
137YES10.47584520
138JAK10.46176507
139RPS6KA60.45665740
140PIK3CA0.45355000
141MTOR0.44963458
142TTN0.44802447
143TNK20.44421775
144LCK0.43756732
145ARAF0.42535468
146PDPK10.42501357
147PIM20.42106034
148GSK3A0.41578034
149KSR20.40667558
150PRKACA0.39395042
151EPHA30.39365233
152CAMK10.38210309
153PDK10.38145522
154BRAF0.37657679
155IGF1R0.36706268
156PRKD10.36239321
157LRRK20.36193586
158MAP2K30.35851308
159ABL10.35424539
160PRKG10.35102093
161MAP2K40.34945305
162CHUK0.33621050

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.71198410
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.05598367
3Steroid biosynthesis_Homo sapiens_hsa001002.87885731
4Fatty acid elongation_Homo sapiens_hsa000622.77859569
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.70316815
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63887691
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.63421354
8Propanoate metabolism_Homo sapiens_hsa006402.46330912
9Fatty acid degradation_Homo sapiens_hsa000712.40208365
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39919214
11Tryptophan metabolism_Homo sapiens_hsa003802.35623676
12Butanoate metabolism_Homo sapiens_hsa006502.27488171
13Peroxisome_Homo sapiens_hsa041462.25220325
14Complement and coagulation cascades_Homo sapiens_hsa046102.20413936
15Histidine metabolism_Homo sapiens_hsa003402.15598826
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14620719
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.13119158
18Fatty acid metabolism_Homo sapiens_hsa012122.09172667
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06981051
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02233348
21Sulfur metabolism_Homo sapiens_hsa009202.01910148
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.89161604
23Arginine biosynthesis_Homo sapiens_hsa002201.88240436
24beta-Alanine metabolism_Homo sapiens_hsa004101.85180400
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.82692783
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79253702
27Nitrogen metabolism_Homo sapiens_hsa009101.76310671
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75517556
29Notch signaling pathway_Homo sapiens_hsa043301.73717964
30Staphylococcus aureus infection_Homo sapiens_hsa051501.69420912
31PPAR signaling pathway_Homo sapiens_hsa033201.69124955
32Chemical carcinogenesis_Homo sapiens_hsa052041.68928663
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68602827
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64202689
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55306152
36Retinol metabolism_Homo sapiens_hsa008301.44589619
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.42102566
38Tyrosine metabolism_Homo sapiens_hsa003501.40229387
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39808265
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39314258
41Phenylalanine metabolism_Homo sapiens_hsa003601.38145943
42Acute myeloid leukemia_Homo sapiens_hsa052211.37608384
43Pyruvate metabolism_Homo sapiens_hsa006201.36232661
44Vitamin B6 metabolism_Homo sapiens_hsa007501.34840448
45Synaptic vesicle cycle_Homo sapiens_hsa047211.33538661
46Folate biosynthesis_Homo sapiens_hsa007901.31004388
47Osteoclast differentiation_Homo sapiens_hsa043801.30002614
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26386902
49Protein export_Homo sapiens_hsa030601.24030815
50Arginine and proline metabolism_Homo sapiens_hsa003301.21496703
51Selenocompound metabolism_Homo sapiens_hsa004501.18999391
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18287868
53VEGF signaling pathway_Homo sapiens_hsa043701.16894365
54Cocaine addiction_Homo sapiens_hsa050301.15908494
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13204959
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13103232
57ABC transporters_Homo sapiens_hsa020101.12468971
58Prolactin signaling pathway_Homo sapiens_hsa049171.12331860
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11904187
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11154216
61Phospholipase D signaling pathway_Homo sapiens_hsa040721.10409278
62Vibrio cholerae infection_Homo sapiens_hsa051101.10002461
63Drug metabolism - other enzymes_Homo sapiens_hsa009831.05594674
64Maturity onset diabetes of the young_Homo sapiens_hsa049501.05360001
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05284559
66Caffeine metabolism_Homo sapiens_hsa002321.05105025
67Vitamin digestion and absorption_Homo sapiens_hsa049771.04815246
68Starch and sucrose metabolism_Homo sapiens_hsa005001.03332945
69Sulfur relay system_Homo sapiens_hsa041221.02549837
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02321283
71Linoleic acid metabolism_Homo sapiens_hsa005910.99676684
72Morphine addiction_Homo sapiens_hsa050320.99604323
73Primary immunodeficiency_Homo sapiens_hsa053400.98910714
74Fat digestion and absorption_Homo sapiens_hsa049750.98448469
75Endocytosis_Homo sapiens_hsa041440.96285880
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95712605
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92356910
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90644659
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.89722423
80Carbon metabolism_Homo sapiens_hsa012000.89638445
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89143884
82GnRH signaling pathway_Homo sapiens_hsa049120.88477546
83Bile secretion_Homo sapiens_hsa049760.88445492
84Type II diabetes mellitus_Homo sapiens_hsa049300.87725996
85Oxidative phosphorylation_Homo sapiens_hsa001900.87099368
86Ether lipid metabolism_Homo sapiens_hsa005650.85659516
87GABAergic synapse_Homo sapiens_hsa047270.85210257
88Choline metabolism in cancer_Homo sapiens_hsa052310.84789248
89Cholinergic synapse_Homo sapiens_hsa047250.84777548
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82812997
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82377208
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.80571396
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80553301
94B cell receptor signaling pathway_Homo sapiens_hsa046620.79404860
95Collecting duct acid secretion_Homo sapiens_hsa049660.79122326
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78572209
97mTOR signaling pathway_Homo sapiens_hsa041500.78201159
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76958073
99Glutamatergic synapse_Homo sapiens_hsa047240.74527535
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74329098
101Pertussis_Homo sapiens_hsa051330.74201386
102Estrogen signaling pathway_Homo sapiens_hsa049150.74019552
103Metabolic pathways_Homo sapiens_hsa011000.73685275
104Circadian entrainment_Homo sapiens_hsa047130.72648349
105Biosynthesis of amino acids_Homo sapiens_hsa012300.72234344
106TNF signaling pathway_Homo sapiens_hsa046680.72157246
107Glutathione metabolism_Homo sapiens_hsa004800.71963412
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71084674
109Amphetamine addiction_Homo sapiens_hsa050310.68647145
110Tuberculosis_Homo sapiens_hsa051520.68220893
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67960603
112Insulin signaling pathway_Homo sapiens_hsa049100.66024909
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64989644
114Glioma_Homo sapiens_hsa052140.63799007
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63715294
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.62849761
117Chronic myeloid leukemia_Homo sapiens_hsa052200.62735350
118Long-term potentiation_Homo sapiens_hsa047200.61436979
119Fatty acid biosynthesis_Homo sapiens_hsa000610.61289586
120Lysine degradation_Homo sapiens_hsa003100.61210651
121Arachidonic acid metabolism_Homo sapiens_hsa005900.61190160
122Non-small cell lung cancer_Homo sapiens_hsa052230.60745683
123Insulin resistance_Homo sapiens_hsa049310.60489254
124Salivary secretion_Homo sapiens_hsa049700.60093182
125Inositol phosphate metabolism_Homo sapiens_hsa005620.59549755
126AMPK signaling pathway_Homo sapiens_hsa041520.57722826
127Gastric acid secretion_Homo sapiens_hsa049710.57691778
128Bladder cancer_Homo sapiens_hsa052190.57042770
129Glycerolipid metabolism_Homo sapiens_hsa005610.56971098
130Hepatitis C_Homo sapiens_hsa051600.56605366
131Hepatitis B_Homo sapiens_hsa051610.56549169
132Axon guidance_Homo sapiens_hsa043600.55953792
133Chemokine signaling pathway_Homo sapiens_hsa040620.55904132
134Pentose phosphate pathway_Homo sapiens_hsa000300.55538926
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55032399
136Other glycan degradation_Homo sapiens_hsa005110.54333655
137Insulin secretion_Homo sapiens_hsa049110.54008227
138Toxoplasmosis_Homo sapiens_hsa051450.53246433
139Ras signaling pathway_Homo sapiens_hsa040140.53057369
140Parkinsons disease_Homo sapiens_hsa050120.52982290
141Sphingolipid metabolism_Homo sapiens_hsa006000.52890541
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51879037
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.51715237
144Rap1 signaling pathway_Homo sapiens_hsa040150.50995996
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50756138
146cAMP signaling pathway_Homo sapiens_hsa040240.50471678
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50110358
148Focal adhesion_Homo sapiens_hsa045100.50031996
149Nicotine addiction_Homo sapiens_hsa050330.49869582
150ECM-receptor interaction_Homo sapiens_hsa045120.49565603
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49215509
152Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49145478
153Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49122560
154Oxytocin signaling pathway_Homo sapiens_hsa049210.48950245
155Cyanoamino acid metabolism_Homo sapiens_hsa004600.44832085
156Alzheimers disease_Homo sapiens_hsa050100.42221187
157Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39010352
158Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31510075
159Glycosaminoglycan degradation_Homo sapiens_hsa005310.30269119
160Lysosome_Homo sapiens_hsa041420.28922623
161Malaria_Homo sapiens_hsa051440.28384387
162One carbon pool by folate_Homo sapiens_hsa006700.27817118
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.20394169
164Fructose and mannose metabolism_Homo sapiens_hsa000510.19189285
165Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.16847828
166Huntingtons disease_Homo sapiens_hsa050160.16265132
167Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13886962
168Autoimmune thyroid disease_Homo sapiens_hsa053200.12741479
169Intestinal immune network for IgA production_Homo sapiens_hsa046720.11616493
170SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09596871
171Prion diseases_Homo sapiens_hsa050200.08138287
172Ovarian steroidogenesis_Homo sapiens_hsa049130.07799323
173Galactose metabolism_Homo sapiens_hsa000520.05659960
174Rheumatoid arthritis_Homo sapiens_hsa053230.05623878
175Adipocytokine signaling pathway_Homo sapiens_hsa049200.03677175
176Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03088078
177Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.02394021
178Phagosome_Homo sapiens_hsa041450.02020756
179Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.01687600

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