LMLN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.60051490
2cilium movement (GO:0003341)7.78147104
3epithelial cilium movement (GO:0003351)7.40250984
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.12521566
5motile cilium assembly (GO:0044458)6.06585468
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.09052618
7intraciliary transport (GO:0042073)5.06254907
8neuron cell-cell adhesion (GO:0007158)4.76160316
9axoneme assembly (GO:0035082)4.70239685
10regulation of cilium movement (GO:0003352)4.64814665
11vocalization behavior (GO:0071625)4.47015077
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.42738088
13ventricular system development (GO:0021591)4.40088663
14regulation of synaptic vesicle exocytosis (GO:2000300)4.36457292
15cilium organization (GO:0044782)4.32563520
16cilium assembly (GO:0042384)4.29115670
17left/right pattern formation (GO:0060972)4.26905707
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.24543991
19locomotory exploration behavior (GO:0035641)4.24019358
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.21283619
21protein localization to cilium (GO:0061512)4.09853223
22transmission of nerve impulse (GO:0019226)3.98373440
23synaptic vesicle exocytosis (GO:0016079)3.98027115
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.94547346
25glutamate receptor signaling pathway (GO:0007215)3.93743256
26regulation of glutamate receptor signaling pathway (GO:1900449)3.91588127
27protein localization to synapse (GO:0035418)3.89118042
28sperm motility (GO:0030317)3.83235643
29cilium morphogenesis (GO:0060271)3.80541651
30synaptic vesicle maturation (GO:0016188)3.79177280
31glutamate secretion (GO:0014047)3.73651608
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.72060558
33exploration behavior (GO:0035640)3.70729463
34regulation of synaptic vesicle transport (GO:1902803)3.68940776
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68411430
36microtubule bundle formation (GO:0001578)3.67911523
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.65708459
38neuron recognition (GO:0008038)3.65497834
39left/right axis specification (GO:0070986)3.63099576
40synaptic transmission, glutamatergic (GO:0035249)3.60009230
41presynaptic membrane assembly (GO:0097105)3.58363137
42neuronal action potential propagation (GO:0019227)3.55371202
43neuron-neuron synaptic transmission (GO:0007270)3.53420774
44cellular component assembly involved in morphogenesis (GO:0010927)3.46917278
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46101997
46layer formation in cerebral cortex (GO:0021819)3.45668185
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.43537444
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.41585437
49response to pheromone (GO:0019236)3.39047149
50axonal fasciculation (GO:0007413)3.37048476
51long-term memory (GO:0007616)3.36619702
52regulation of neuronal synaptic plasticity (GO:0048168)3.33079284
53gamma-aminobutyric acid transport (GO:0015812)3.32869911
54microtubule-based movement (GO:0007018)3.32832713
55regulation of neurotransmitter secretion (GO:0046928)3.32386376
56acrosome reaction (GO:0007340)3.31709938
57presynaptic membrane organization (GO:0097090)3.31206549
58cerebellar Purkinje cell differentiation (GO:0021702)3.27618816
59neurotransmitter secretion (GO:0007269)3.25826634
60startle response (GO:0001964)3.23470175
61innervation (GO:0060384)3.23175448
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21315328
63mating behavior (GO:0007617)3.19858172
64positive regulation of synapse maturation (GO:0090129)3.19207387
65microtubule depolymerization (GO:0007019)3.18001034
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17629368
67regulation of microtubule-based movement (GO:0060632)3.16361612
68synaptic vesicle endocytosis (GO:0048488)3.14601193
69regulation of postsynaptic membrane potential (GO:0060078)3.13816759
70negative regulation of neurotransmitter transport (GO:0051589)3.12318042
71apical protein localization (GO:0045176)3.11609488
72neurotransmitter-gated ion channel clustering (GO:0072578)3.10659604
73behavioral defense response (GO:0002209)3.08188754
74behavioral fear response (GO:0001662)3.08188754
75nonmotile primary cilium assembly (GO:0035058)3.07908369
76long-term synaptic potentiation (GO:0060291)3.07096535
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05673283
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.05371998
79neurotransmitter transport (GO:0006836)3.05322776
80synapse assembly (GO:0007416)3.04261537
81multicellular organism reproduction (GO:0032504)3.02384142
82centriole replication (GO:0007099)3.00986145
83response to histamine (GO:0034776)2.99047055
84proline transport (GO:0015824)2.98610349
85glycine transport (GO:0015816)2.96931726
86chemosensory behavior (GO:0007635)2.96494129
87regulation of vesicle fusion (GO:0031338)2.95249189
88dendritic spine morphogenesis (GO:0060997)2.94969205
89smoothened signaling pathway (GO:0007224)2.94883593
90cellular potassium ion homeostasis (GO:0030007)2.93630484
91regulation of neurotransmitter transport (GO:0051588)2.93004759
92L-amino acid import (GO:0043092)2.92094940
93regulation of synapse maturation (GO:0090128)2.90516184
94adult walking behavior (GO:0007628)2.89187507
95fear response (GO:0042596)2.88784648
96membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88259292
97synaptic vesicle docking involved in exocytosis (GO:0016081)2.84990141
98dendrite morphogenesis (GO:0048813)2.84510068
99detection of calcium ion (GO:0005513)2.84107780
100microtubule polymerization or depolymerization (GO:0031109)2.83222757
101postsynaptic membrane organization (GO:0001941)2.82858828
102membrane depolarization during action potential (GO:0086010)2.82719489
103centriole assembly (GO:0098534)2.82331330
104behavioral response to nicotine (GO:0035095)2.81516550
105membrane depolarization (GO:0051899)2.81355862
106spermatid development (GO:0007286)2.80602453
107membrane hyperpolarization (GO:0060081)2.80399289
108negative regulation of neurotransmitter secretion (GO:0046929)2.79470095
109regulation of synaptic plasticity (GO:0048167)2.79314270
110cerebral cortex radially oriented cell migration (GO:0021799)2.78950515
111learning (GO:0007612)2.77668376
112eye photoreceptor cell differentiation (GO:0001754)2.75091904
113photoreceptor cell differentiation (GO:0046530)2.75091904
114long-chain fatty acid biosynthetic process (GO:0042759)2.74868033
115synapse organization (GO:0050808)2.74741445
116regulation of dendritic spine morphogenesis (GO:0061001)2.73243375
117cell projection assembly (GO:0030031)2.71831700
118positive regulation of synapse assembly (GO:0051965)2.71542840
119regulation of action potential (GO:0098900)2.70972980
120regulation of synapse structural plasticity (GO:0051823)2.68572676
121limb development (GO:0060173)2.67622363
122appendage development (GO:0048736)2.67622363
123protein polyglutamylation (GO:0018095)2.66433266
124microtubule severing (GO:0051013)2.66194953
125positive regulation of action potential (GO:0045760)2.64762145
126cilium or flagellum-dependent cell motility (GO:0001539)2.64038555
127regulation of rhodopsin mediated signaling pathway (GO:0022400)2.64021373
128regulation of synaptic transmission, GABAergic (GO:0032228)2.63844386
129calcium ion import (GO:0070509)2.62384077
130response to auditory stimulus (GO:0010996)2.62145600
131substrate-independent telencephalic tangential migration (GO:0021826)2.61909540
132substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.61909540
133cell migration in hindbrain (GO:0021535)2.61420855
134positive regulation of membrane potential (GO:0045838)2.60653171
135dendrite development (GO:0016358)2.60634515
136tachykinin receptor signaling pathway (GO:0007217)2.59903970
137establishment of mitochondrion localization (GO:0051654)2.59563990
138positive regulation of dendritic spine morphogenesis (GO:0061003)2.59148516
139rhodopsin mediated signaling pathway (GO:0016056)2.58682364
140phosphorelay signal transduction system (GO:0000160)2.58653306
141limb bud formation (GO:0060174)2.58561246
142iron ion import (GO:0097286)2.58386640
143photoreceptor cell maintenance (GO:0045494)2.52362211
144retinal cone cell development (GO:0046549)2.48616669
145determination of left/right symmetry (GO:0007368)2.48027495
146retinal rod cell development (GO:0046548)2.46550846
147pyrimidine nucleobase catabolic process (GO:0006208)2.44917532
148determination of bilateral symmetry (GO:0009855)2.43989094
149peristalsis (GO:0030432)2.42233861
150calcium ion-dependent exocytosis (GO:0017156)2.40006118
151specification of symmetry (GO:0009799)2.39726392
152establishment of protein localization to Golgi (GO:0072600)2.39563862
153sex differentiation (GO:0007548)2.37110798
154auditory behavior (GO:0031223)2.36297495
155ADP metabolic process (GO:0046031)2.34828970
156microtubule-based process (GO:0007017)2.34269602
157mechanosensory behavior (GO:0007638)2.33897761
158microtubule-based transport (GO:0010970)2.27242665
159organelle assembly (GO:0070925)2.25148546
160embryonic body morphogenesis (GO:0010172)2.22307490
161cytoskeleton-dependent intracellular transport (GO:0030705)2.20094633
162sperm capacitation (GO:0048240)2.19302437
163single fertilization (GO:0007338)2.18497818
164indole-containing compound catabolic process (GO:0042436)2.16008622
165indolalkylamine catabolic process (GO:0046218)2.16008622
166tryptophan catabolic process (GO:0006569)2.16008622
167lateral ventricle development (GO:0021670)2.15417647
168male meiosis (GO:0007140)2.15108464
169sensory perception of smell (GO:0007608)2.13921782
170photoreceptor cell development (GO:0042461)2.12768749
171coenzyme catabolic process (GO:0009109)2.12553110
172synapsis (GO:0007129)2.12330377
173calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.12014473
174regulation of collateral sprouting (GO:0048670)2.11516260
175negative regulation of multicellular organism growth (GO:0040015)2.07162971
176cytoplasmic mRNA processing body assembly (GO:0033962)2.06045341
177phasic smooth muscle contraction (GO:0014821)2.06000522
178cornea development in camera-type eye (GO:0061303)2.05768907
179regulation of hippo signaling (GO:0035330)2.05320945
180behavioral response to ethanol (GO:0048149)2.03903176
181establishment or maintenance of monopolar cell polarity (GO:0061339)2.03810827
182establishment of monopolar cell polarity (GO:0061162)2.03810827
183nucleobase catabolic process (GO:0046113)2.03314937
184resolution of meiotic recombination intermediates (GO:0000712)2.03056986
185protein targeting to Golgi (GO:0000042)2.02330073
186indolalkylamine metabolic process (GO:0006586)2.01938417
187lung epithelium development (GO:0060428)2.00440373
188cellular ketone body metabolic process (GO:0046950)2.00410880
189positive regulation of mitochondrial fission (GO:0090141)2.00065401
190meiotic chromosome segregation (GO:0045132)2.00034534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.63587756
2GBX2_23144817_ChIP-Seq_PC3_Human4.01627052
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76684617
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67698978
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64161841
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38319520
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30964966
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30964966
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30703904
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30694798
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.26463952
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.26421743
13REST_21632747_ChIP-Seq_MESCs_Mouse2.17665469
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15880664
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15845595
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15564706
17DROSHA_22980978_ChIP-Seq_HELA_Human2.14872883
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.14592574
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14498343
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.03302170
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.02817329
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01075422
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00183427
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.95876631
25IGF1R_20145208_ChIP-Seq_DFB_Human1.95669819
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95280197
27AR_21572438_ChIP-Seq_LNCaP_Human1.93390537
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93052159
29SMAD4_21799915_ChIP-Seq_A2780_Human1.92154129
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91211761
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90028147
32TAF15_26573619_Chip-Seq_HEK293_Human1.85475793
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80906681
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.79947660
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.74064647
36P300_19829295_ChIP-Seq_ESCs_Human1.69567125
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68440874
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.67638840
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61740664
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.57906743
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57714449
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57549036
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54733513
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54147420
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53222895
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52586610
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.48624277
48* STAT3_23295773_ChIP-Seq_U87_Human1.47446475
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47236249
50EWS_26573619_Chip-Seq_HEK293_Human1.46820337
51AHR_22903824_ChIP-Seq_MCF-7_Human1.46545035
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46181492
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45287901
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45260474
55CBP_20019798_ChIP-Seq_JUKART_Human1.45260474
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43297264
57TP53_16413492_ChIP-PET_HCT116_Human1.41353462
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40094675
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.40065181
60RNF2_27304074_Chip-Seq_NSC_Mouse1.39891401
61TCF4_23295773_ChIP-Seq_U87_Human1.39875275
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38953968
63FUS_26573619_Chip-Seq_HEK293_Human1.37362096
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.37351564
65VDR_22108803_ChIP-Seq_LS180_Human1.37131121
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36925924
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35140048
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34600622
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.34029534
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31605002
71* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30471843
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30099629
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30091964
74TBL1_22424771_ChIP-Seq_293T_Human1.29980587
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28872453
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28773181
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.25926670
78AR_25329375_ChIP-Seq_VCAP_Human1.25557008
79BCAT_22108803_ChIP-Seq_LS180_Human1.25362337
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23989438
81TCF4_22108803_ChIP-Seq_LS180_Human1.23482478
82AR_19668381_ChIP-Seq_PC3_Human1.23198143
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20611517
84* ER_23166858_ChIP-Seq_MCF-7_Human1.19674634
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19331827
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17967748
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17846022
88ZNF274_21170338_ChIP-Seq_K562_Hela1.17302938
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16330787
90RUNX2_22187159_ChIP-Seq_PCA_Human1.14266625
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13875906
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.13256977
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.12608678
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12422209
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.11686847
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11555435
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11298191
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11296446
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11212156
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10777731
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10732080
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.10375608
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.09866074
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09609017
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.07501572
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07365387
107NFYB_21822215_ChIP-Seq_K562_Human1.06683802
108P53_22387025_ChIP-Seq_ESCs_Mouse1.06134698
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05894555
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05894555
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05225858
112SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03955721
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03910826
114TP53_18474530_ChIP-ChIP_U2OS_Human1.03845012
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03806822
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03073107
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02658361
118ERG_21242973_ChIP-ChIP_JURKAT_Human1.02309937
119CJUN_26792858_Chip-Seq_BT549_Human1.02234336
120YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01848720
121PHF8_20622853_ChIP-Seq_HELA_Human1.01335987
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01256377
123NFYA_21822215_ChIP-Seq_K562_Human0.97320081
124* PRDM14_20953172_ChIP-Seq_ESCs_Human0.96775456
125JUN_21703547_ChIP-Seq_K562_Human0.96690590
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.96226371
127TAL1_26923725_Chip-Seq_HPCs_Mouse0.94979802
128ETV1_20927104_ChIP-Seq_GIST48_Human0.94517393
129CDX2_22108803_ChIP-Seq_LS180_Human0.94456352
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.93204399
131OCT1_27270436_Chip-Seq_PROSTATE_Human0.93155929
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92895312
133FLI1_21867929_ChIP-Seq_TH2_Mouse0.92759426
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92608657
135CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92604972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.77282938
2MP0003880_abnormal_central_pattern4.16586292
3MP0003635_abnormal_synaptic_transmissio3.42278117
4MP0004270_analgesia3.22708376
5MP0002822_catalepsy3.13869361
6MP0009745_abnormal_behavioral_response2.99810581
7MP0009046_muscle_twitch2.92398435
8MP0002063_abnormal_learning/memory/cond2.88211199
9MP0002064_seizures2.74046847
10MP0001486_abnormal_startle_reflex2.57244644
11MP0002272_abnormal_nervous_system2.52034218
12MP0001968_abnormal_touch/_nociception2.51916083
13MP0002572_abnormal_emotion/affect_behav2.51471991
14MP0005551_abnormal_eye_electrophysiolog2.49649483
15MP0000778_abnormal_nervous_system2.26209413
16MP0003195_calcinosis2.23895087
17MP0002102_abnormal_ear_morphology2.22265821
18MP0002736_abnormal_nociception_after2.12554237
19MP0002735_abnormal_chemical_nociception2.09293032
20MP0002734_abnormal_mechanical_nocicepti2.08808330
21MP0005423_abnormal_somatic_nervous2.07554100
22MP0005394_taste/olfaction_phenotype2.02654278
23MP0005499_abnormal_olfactory_system2.02654278
24MP0001440_abnormal_grooming_behavior2.01231253
25MP0002067_abnormal_sensory_capabilities1.99774639
26MP0006276_abnormal_autonomic_nervous1.95108404
27MP0008789_abnormal_olfactory_epithelium1.93718637
28MP0008875_abnormal_xenobiotic_pharmacok1.92023661
29MP0003787_abnormal_imprinting1.81030677
30MP0002234_abnormal_pharynx_morphology1.79736276
31MP0002557_abnormal_social/conspecific_i1.77924601
32MP0002184_abnormal_innervation1.77920920
33MP0001501_abnormal_sleep_pattern1.73318090
34MP0005167_abnormal_blood-brain_barrier1.73148501
35MP0004043_abnormal_pH_regulation1.71715498
36MP0002733_abnormal_thermal_nociception1.70699663
37MP0004924_abnormal_behavior1.66968800
38MP0005386_behavior/neurological_phenoty1.66968800
39MP0006072_abnormal_retinal_apoptosis1.64400934
40MP0005646_abnormal_pituitary_gland1.59943046
41MP0001529_abnormal_vocalization1.57751150
42MP0003890_abnormal_embryonic-extraembry1.57186240
43MP0004742_abnormal_vestibular_system1.56695379
44MP0002160_abnormal_reproductive_system1.54027584
45MP0004142_abnormal_muscle_tone1.53846854
46MP0001970_abnormal_pain_threshold1.52935100
47MP0002882_abnormal_neuron_morphology1.52923568
48MP0004858_abnormal_nervous_system1.52500935
49MP0005253_abnormal_eye_physiology1.51321218
50MP0000427_abnormal_hair_cycle1.50283232
51MP0005187_abnormal_penis_morphology1.47964947
52MP0002229_neurodegeneration1.47521229
53MP0005645_abnormal_hypothalamus_physiol1.46682069
54MP0009780_abnormal_chondrocyte_physiolo1.45671045
55MP0000955_abnormal_spinal_cord1.44490659
56MP0000383_abnormal_hair_follicle1.42961764
57MP0001984_abnormal_olfaction1.39683397
58MP0004885_abnormal_endolymph1.38778022
59MP0008569_lethality_at_weaning1.38509086
60MP0000569_abnormal_digit_pigmentation1.37865701
61MP0004811_abnormal_neuron_physiology1.36155753
62MP0003329_amyloid_beta_deposits1.33017196
63MP0005410_abnormal_fertilization1.32544997
64MP0002066_abnormal_motor_capabilities/c1.32107836
65MP0003633_abnormal_nervous_system1.31134692
66MP0001502_abnormal_circadian_rhythm1.31043286
67MP0001188_hyperpigmentation1.30836015
68MP0008877_abnormal_DNA_methylation1.29936143
69MP0003718_maternal_effect1.28481525
70MP0003631_nervous_system_phenotype1.25750032
71MP0003634_abnormal_glial_cell1.25725337
72MP0004145_abnormal_muscle_electrophysio1.23635646
73MP0002752_abnormal_somatic_nervous1.21751750
74MP0002837_dystrophic_cardiac_calcinosis1.21536164
75MP0000566_synostosis1.21407238
76MP0002282_abnormal_trachea_morphology1.21094815
77MP0002638_abnormal_pupillary_reflex1.19380883
78MP0000920_abnormal_myelination1.18591569
79MP0001963_abnormal_hearing_physiology1.18509641
80MP0001929_abnormal_gametogenesis1.18197343
81MP0002233_abnormal_nose_morphology1.16518772
82MP0002928_abnormal_bile_duct1.15930908
83MP0001905_abnormal_dopamine_level1.15570278
84MP0003122_maternal_imprinting1.15130707
85MP0002152_abnormal_brain_morphology1.14374193
86MP0000631_abnormal_neuroendocrine_gland1.12852304
87MP0001293_anophthalmia1.10495221
88MP0005623_abnormal_meninges_morphology1.09537245
89MP0005195_abnormal_posterior_eye1.09227477
90MP0005377_hearing/vestibular/ear_phenot1.09220540
91MP0003878_abnormal_ear_physiology1.09220540
92MP0002090_abnormal_vision1.08795934
93MP0003632_abnormal_nervous_system1.08113734
94MP0006292_abnormal_olfactory_placode1.05928036
95MP0002210_abnormal_sex_determination1.02932976
96MP0003690_abnormal_glial_cell1.02823544
97MP0003937_abnormal_limbs/digits/tail_de1.01516332
98MP0010386_abnormal_urinary_bladder1.00521172
99MP0003136_yellow_coat_color0.99926639
100MP0004147_increased_porphyrin_level0.96734444
101MP0000647_abnormal_sebaceous_gland0.96348445
102MP0010678_abnormal_skin_adnexa0.95888037
103MP0003942_abnormal_urinary_system0.93099518
104MP0005083_abnormal_biliary_tract0.93093088
105MP0005395_other_phenotype0.92199808
106MP0001324_abnormal_eye_pigmentation0.90969392
107MP0005171_absent_coat_pigmentation0.90214699
108MP0003755_abnormal_palate_morphology0.89890045
109MP0003121_genomic_imprinting0.88242749
110MP0008872_abnormal_physiological_respon0.87335381
111MP0003950_abnormal_plasma_membrane0.86562702
112MP0003698_abnormal_male_reproductive0.85947515
113MP0001485_abnormal_pinna_reflex0.85482352
114MP0005389_reproductive_system_phenotype0.85176397
115MP0000026_abnormal_inner_ear0.84862408
116MP0002876_abnormal_thyroid_physiology0.84739857
117MP0003879_abnormal_hair_cell0.82440824
118MP0002938_white_spotting0.82321509
119MP0002653_abnormal_ependyma_morphology0.80135224
120MP0001299_abnormal_eye_distance/0.79478893
121MP0002909_abnormal_adrenal_gland0.78695384
122MP0000751_myopathy0.75694422
123MP0003861_abnormal_nervous_system0.75519005
124MP0004085_abnormal_heartbeat0.73216759
125MP0002069_abnormal_eating/drinking_beha0.72373785
126MP0004133_heterotaxia0.71367838
127MP0004484_altered_response_of0.69561320
128MP0005248_abnormal_Harderian_gland0.69437164
129MP0001986_abnormal_taste_sensitivity0.65693946
130MP0005409_darkened_coat_color0.65254863
131MP0003137_abnormal_impulse_conducting0.64380652
132MP0001177_atelectasis0.63726278
133MP0005391_vision/eye_phenotype0.62911445
134MP0004134_abnormal_chest_morphology0.60328878
135MP0002751_abnormal_autonomic_nervous0.59781228

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.06959128
2Pancreatic fibrosis (HP:0100732)4.39357969
3Epileptic encephalopathy (HP:0200134)4.17936390
4True hermaphroditism (HP:0010459)4.07396268
5Myokymia (HP:0002411)4.03494794
6Focal seizures (HP:0007359)4.00347717
7Pancreatic cysts (HP:0001737)3.95423821
8Chronic bronchitis (HP:0004469)3.84256699
9Abnormality of midbrain morphology (HP:0002418)3.82061648
10Molar tooth sign on MRI (HP:0002419)3.82061648
11Febrile seizures (HP:0002373)3.70946525
12Progressive cerebellar ataxia (HP:0002073)3.63257024
13Bronchiectasis (HP:0002110)3.59359613
14Occipital encephalocele (HP:0002085)3.55702766
15Atonic seizures (HP:0010819)3.39516363
16Congenital stationary night blindness (HP:0007642)3.33773347
17Chronic hepatic failure (HP:0100626)3.31360146
18Cystic liver disease (HP:0006706)3.27173711
19Abnormality of the renal medulla (HP:0100957)3.23661822
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.16322310
21Visual hallucinations (HP:0002367)3.15649012
22Broad-based gait (HP:0002136)3.11183906
23Tubulointerstitial nephritis (HP:0001970)3.10418104
24Vitreoretinal degeneration (HP:0000655)3.05275941
25Nephrogenic diabetes insipidus (HP:0009806)2.98764175
26Infertility (HP:0000789)2.98276219
27Supranuclear gaze palsy (HP:0000605)2.95401024
28Abnormal respiratory motile cilium physiology (HP:0012261)2.90413352
29Abnormal ciliary motility (HP:0012262)2.89584954
30Absent/shortened dynein arms (HP:0200106)2.87521029
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.87521029
32Postaxial foot polydactyly (HP:0001830)2.86149596
33Poor coordination (HP:0002370)2.83955083
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.83629166
35Hyperventilation (HP:0002883)2.80084774
36Central scotoma (HP:0000603)2.71627999
37Abnormality of macular pigmentation (HP:0008002)2.71100147
38Generalized tonic-clonic seizures (HP:0002069)2.70607036
39Absence seizures (HP:0002121)2.68761952
40Neurofibrillary tangles (HP:0002185)2.66930992
41Anencephaly (HP:0002323)2.66489122
42Dialeptic seizures (HP:0011146)2.66102399
43Nasal polyposis (HP:0100582)2.64640583
44Bony spicule pigmentary retinopathy (HP:0007737)2.64016115
45Gaze-evoked nystagmus (HP:0000640)2.60827606
46Absent speech (HP:0001344)2.55357059
47Drooling (HP:0002307)2.54094392
48Excessive salivation (HP:0003781)2.54094392
49Tubular atrophy (HP:0000092)2.49878501
50Termporal pattern (HP:0011008)2.47403828
51Insidious onset (HP:0003587)2.47403828
52Abnormality of the corticospinal tract (HP:0002492)2.46449422
53Sclerocornea (HP:0000647)2.46052002
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.45820434
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.45820434
56Congenital hepatic fibrosis (HP:0002612)2.44932742
57Aqueductal stenosis (HP:0002410)2.43559620
58Epiphyseal dysplasia (HP:0002656)2.43227076
59Vaginal atresia (HP:0000148)2.40325180
60Truncal ataxia (HP:0002078)2.40121757
61Cerebral inclusion bodies (HP:0100314)2.39953456
62Abnormal rod and cone electroretinograms (HP:0008323)2.39256993
63Postaxial hand polydactyly (HP:0001162)2.34481988
64Male pseudohermaphroditism (HP:0000037)2.31960981
65Urinary bladder sphincter dysfunction (HP:0002839)2.31114686
66Dysmetria (HP:0001310)2.30459910
67Abnormality of the renal cortex (HP:0011035)2.26904700
68Retinal atrophy (HP:0001105)2.25647281
69Dysdiadochokinesis (HP:0002075)2.24731225
70Male infertility (HP:0003251)2.20040800
71Action tremor (HP:0002345)2.19108729
72Preaxial hand polydactyly (HP:0001177)2.18028068
73Hemiparesis (HP:0001269)2.15825708
74Depression (HP:0000716)2.14573523
75Impaired vibration sensation in the lower limbs (HP:0002166)2.11599320
76Urinary urgency (HP:0000012)2.10859669
77Decreased central vision (HP:0007663)2.10691534
78Scanning speech (HP:0002168)2.09410294
79Gait imbalance (HP:0002141)2.09146368
80Ankle clonus (HP:0011448)2.08928588
81Retinal dysplasia (HP:0007973)2.08785317
82Sensory axonal neuropathy (HP:0003390)2.08537375
83Impaired smooth pursuit (HP:0007772)2.07656358
84Oligodactyly (hands) (HP:0001180)2.07474930
85Spastic gait (HP:0002064)2.05955059
86Polydipsia (HP:0001959)2.03971898
87Abnormal drinking behavior (HP:0030082)2.03971898
88Abnormal respiratory epithelium morphology (HP:0012253)2.03404235
89Abnormal respiratory motile cilium morphology (HP:0005938)2.03404235
90Pheochromocytoma (HP:0002666)2.02341273
91Relative macrocephaly (HP:0004482)2.00124847
92Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99059826
93Severe visual impairment (HP:0001141)1.98970388
94Scotoma (HP:0000575)1.97757299
95Type II lissencephaly (HP:0007260)1.97755383
96Poor eye contact (HP:0000817)1.97403039
97Rhinitis (HP:0012384)1.96074212
98Widely spaced teeth (HP:0000687)1.95476635
99Fetal akinesia sequence (HP:0001989)1.94010284
100Aplasia/Hypoplasia of the lens (HP:0008063)1.93888658
101Oculomotor apraxia (HP:0000657)1.93547934
102Thyroid-stimulating hormone excess (HP:0002925)1.92940653
103Median cleft lip (HP:0000161)1.92915411
104Epileptiform EEG discharges (HP:0011182)1.91504904
105Dyschromatopsia (HP:0007641)1.90943507
106Postural instability (HP:0002172)1.89020696
107Abnormality of the nasal mucosa (HP:0000433)1.88034199
108Nephronophthisis (HP:0000090)1.87888220
109Choroideremia (HP:0001139)1.87033389
110Renal dysplasia (HP:0000110)1.86600731
111Akinesia (HP:0002304)1.86540763
112Cerebellar dysplasia (HP:0007033)1.85618445
113Chronic sinusitis (HP:0011109)1.85380673
114Severe Myopia (HP:0011003)1.84986325
115Amblyopia (HP:0000646)1.84821381
116Genetic anticipation (HP:0003743)1.82967346
117Congenital primary aphakia (HP:0007707)1.80513716
118Abnormality of ocular smooth pursuit (HP:0000617)1.80359704
119EEG with generalized epileptiform discharges (HP:0011198)1.80177406
120Abnormality of salivation (HP:0100755)1.79124483
121Lower limb muscle weakness (HP:0007340)1.77722052
122Aganglionic megacolon (HP:0002251)1.77658578
123Incomplete penetrance (HP:0003829)1.75235134
124Impaired social interactions (HP:0000735)1.74473949
125Abnormal social behavior (HP:0012433)1.74473949
126Tubulointerstitial abnormality (HP:0001969)1.74461027
127Genital tract atresia (HP:0001827)1.74454317
128Hypoplasia of the brainstem (HP:0002365)1.73037617
129Aplasia/Hypoplasia of the brainstem (HP:0007362)1.73037617
130Specific learning disability (HP:0001328)1.72887487
131Anxiety (HP:0000739)1.71812405
132Abnormality of the aortic arch (HP:0012303)1.71659707
133Pendular nystagmus (HP:0012043)1.71265794
134Protruding tongue (HP:0010808)1.71215029
135Prominent nasal bridge (HP:0000426)1.71077876
136Neuroendocrine neoplasm (HP:0100634)1.71050247
137Astigmatism (HP:0000483)1.69194362
138Supernumerary spleens (HP:0009799)1.68942715
139Insomnia (HP:0100785)1.67376694
140Medial flaring of the eyebrow (HP:0010747)1.67139039
141Diplopia (HP:0000651)1.65892363
142Abnormality of binocular vision (HP:0011514)1.65892363
143Atelectasis (HP:0100750)1.65070736
144Highly arched eyebrow (HP:0002553)1.64147193
145Retinitis pigmentosa (HP:0000510)1.63156659
146Disproportionate short-trunk short stature (HP:0003521)1.62617842
147Furrowed tongue (HP:0000221)1.62549978
148Short foot (HP:0001773)1.60823885
149Decreased testicular size (HP:0008734)1.57737137
150Stage 5 chronic kidney disease (HP:0003774)1.57292594
151Pachygyria (HP:0001302)1.56663006
152Narrow forehead (HP:0000341)1.55948468
153Multicystic kidney dysplasia (HP:0000003)1.54321421
154Oligodactyly (HP:0012165)1.53902495
155Dysmetric saccades (HP:0000641)1.49117383
156Broad foot (HP:0001769)1.44410865
157Left ventricular hypertrophy (HP:0001712)1.43151121
158Bell-shaped thorax (HP:0001591)1.40800849
159Bronchitis (HP:0012387)1.34174903

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.19662915
2CASK3.98663377
3FRK3.50399080
4MAPK153.44007222
5ACVR1B3.02002962
6MAP3K92.99271422
7EPHA42.90312327
8MARK12.83834035
9BMPR1B2.71315764
10MAP3K42.57494694
11PNCK2.47592480
12GRK12.20734191
13MAP2K72.11348621
14MINK11.98777182
15PAK61.93951722
16LATS11.93040735
17STK391.88567707
18NTRK21.82164492
19WNK11.75067014
20PRPF4B1.73079769
21EPHA31.67632807
22RIPK41.63357271
23ADRBK21.58326178
24TRIM281.57314070
25MET1.51982363
26STK38L1.49729500
27PLK21.43444136
28NTRK11.42722894
29CDK121.40034529
30OXSR11.38655322
31MAPK131.36346263
32BRD41.31230073
33EPHA21.28874396
34MARK31.28264935
35EIF2AK11.27934201
36EPHB21.27296099
37MST41.24251951
38TNIK1.21637400
39CDK51.20842076
40PRKD31.19976228
41PKN11.19110719
42MAP2K41.18392130
43SGK2231.18009483
44SGK4941.18009483
45CAMK1G1.17432539
46STK381.16923331
47MAP4K21.16650714
48MAP3K121.16170734
49KSR11.15199476
50MST1R1.13959343
51WNK41.12433184
52CAMK2A1.11179963
53CAMK2B1.10529386
54BCR1.10370421
55WNK31.09293925
56NME11.09106042
57PRKCG1.08897271
58CAMKK11.06669089
59INSRR1.05740337
60FER1.01689321
61STK31.00565789
62NEK60.97344519
63PHKG10.96498777
64PHKG20.96498777
65UHMK10.93727278
66SGK20.90255067
67ERBB30.90121046
68DYRK30.90013631
69BMPR20.89256450
70CSNK1G20.88587208
71KSR20.87965887
72MKNK20.87351264
73SGK10.85897228
74SIK20.85265238
75CAMKK20.84025302
76STK110.82466942
77FES0.80681395
78PLK40.80395092
79CAMK2D0.80046196
80PRKCE0.78888480
81FGR0.77975258
82GRK50.77368350
83PINK10.77211016
84DAPK20.75297597
85PTK2B0.74216325
86TYRO30.73307993
87CSNK1G30.72146795
88ALK0.71113806
89MAPK100.70751799
90NEK20.70004729
91CSNK1A1L0.68974576
92DYRK1A0.68903749
93BRSK20.67806605
94CDC42BPA0.66176384
95PAK30.66137367
96MAPKAPK30.64541101
97CDK140.63098256
98GRK70.63060701
99CDK30.62971069
100DAPK10.62661457
101MARK20.62517228
102TGFBR10.61539127
103FLT30.61407072
104MYLK0.61198505
105CDK180.60466425
106MAP3K20.60394620
107CDK150.59584875
108DYRK20.58710932
109PBK0.57938331
110WEE10.57674172
111TNK20.54625225
112SIK30.54417927
113CAMK2G0.54277733
114ROCK20.53621519
115FGFR20.53571886
116LATS20.53221975
117ADRBK10.52350660
118PLK10.52343351
119DMPK0.52152007
120PRKAA10.51941345
121AKT30.51848687
122PRKCH0.51008302
123SGK30.50717642
124RET0.48858260
125CAMK10.48059011
126CDK190.47977733
127RPS6KA30.46268373
128CAMK1D0.46102445
129ICK0.45630614
130CDK11A0.45462367
131PRKG10.45100418
132PRKCB0.45067224
133TTK0.44125212
134RPS6KA20.43923632
135CCNB10.43169867
136PKN20.42529608
137PRKCZ0.42519246
138ERBB20.41980934
139CSNK1D0.41315940
140MAP3K70.41134437
141CSNK1E0.40963682
142CSNK1G10.40371761
143GSK3B0.40086135
144DDR20.39746702
145ATM0.39502074
146BMX0.38655357
147MKNK10.36946684

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.85369434
2Phototransduction_Homo sapiens_hsa047443.20968144
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67979421
4Synaptic vesicle cycle_Homo sapiens_hsa047212.59965546
5GABAergic synapse_Homo sapiens_hsa047272.57415134
6Morphine addiction_Homo sapiens_hsa050322.52025035
7Olfactory transduction_Homo sapiens_hsa047402.47665358
8Circadian entrainment_Homo sapiens_hsa047132.46527476
9Glutamatergic synapse_Homo sapiens_hsa047242.45583454
10Long-term potentiation_Homo sapiens_hsa047202.32674092
11Taste transduction_Homo sapiens_hsa047422.27163330
12Amphetamine addiction_Homo sapiens_hsa050312.20799976
13Serotonergic synapse_Homo sapiens_hsa047262.11051802
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.00218286
15Salivary secretion_Homo sapiens_hsa049701.96190619
16Dopaminergic synapse_Homo sapiens_hsa047281.95309011
17Insulin secretion_Homo sapiens_hsa049111.87225591
18Cholinergic synapse_Homo sapiens_hsa047251.86215620
19Long-term depression_Homo sapiens_hsa047301.81079490
20Renin secretion_Homo sapiens_hsa049241.80939097
21Cocaine addiction_Homo sapiens_hsa050301.78124697
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70346716
23Circadian rhythm_Homo sapiens_hsa047101.69227713
24Axon guidance_Homo sapiens_hsa043601.68738665
25Calcium signaling pathway_Homo sapiens_hsa040201.59482075
26Butanoate metabolism_Homo sapiens_hsa006501.56467265
27Gastric acid secretion_Homo sapiens_hsa049711.52310981
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51994444
29Oxytocin signaling pathway_Homo sapiens_hsa049211.51648999
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50718466
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50176257
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49693892
33Basal transcription factors_Homo sapiens_hsa030221.41534551
34beta-Alanine metabolism_Homo sapiens_hsa004101.41237446
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39246452
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.38917156
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37052202
38Huntingtons disease_Homo sapiens_hsa050161.36194789
39Propanoate metabolism_Homo sapiens_hsa006401.34111192
40Nitrogen metabolism_Homo sapiens_hsa009101.32259050
41cAMP signaling pathway_Homo sapiens_hsa040241.32177510
42ABC transporters_Homo sapiens_hsa020101.27823469
43Dorso-ventral axis formation_Homo sapiens_hsa043201.23031620
44Gap junction_Homo sapiens_hsa045401.21862936
45Chemical carcinogenesis_Homo sapiens_hsa052041.21620154
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21160361
47GnRH signaling pathway_Homo sapiens_hsa049121.20748159
48Estrogen signaling pathway_Homo sapiens_hsa049151.18066873
49Melanogenesis_Homo sapiens_hsa049161.16943111
50ErbB signaling pathway_Homo sapiens_hsa040121.16752341
51Collecting duct acid secretion_Homo sapiens_hsa049661.14940888
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11843358
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11325577
54Fanconi anemia pathway_Homo sapiens_hsa034601.10739407
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10701838
56Linoleic acid metabolism_Homo sapiens_hsa005911.07450815
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06814941
58Tryptophan metabolism_Homo sapiens_hsa003801.05290538
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.00810057
60Glioma_Homo sapiens_hsa052140.98501900
61Histidine metabolism_Homo sapiens_hsa003400.98263392
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96610136
63Cardiac muscle contraction_Homo sapiens_hsa042600.95948456
64Steroid biosynthesis_Homo sapiens_hsa001000.93275803
65Caffeine metabolism_Homo sapiens_hsa002320.92851347
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.89463561
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.89314561
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86861342
69Vibrio cholerae infection_Homo sapiens_hsa051100.86535896
70Adherens junction_Homo sapiens_hsa045200.84272796
71Oocyte meiosis_Homo sapiens_hsa041140.84197196
72Type II diabetes mellitus_Homo sapiens_hsa049300.84097055
73Lysine degradation_Homo sapiens_hsa003100.84069992
74Choline metabolism in cancer_Homo sapiens_hsa052310.79271458
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79225177
76Dilated cardiomyopathy_Homo sapiens_hsa054140.79134709
77Ovarian steroidogenesis_Homo sapiens_hsa049130.78515757
78Glutathione metabolism_Homo sapiens_hsa004800.78127403
79Selenocompound metabolism_Homo sapiens_hsa004500.77929134
80Thyroid hormone synthesis_Homo sapiens_hsa049180.76503834
81Retinol metabolism_Homo sapiens_hsa008300.76143679
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75712324
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75245873
84MAPK signaling pathway_Homo sapiens_hsa040100.74823139
85Peroxisome_Homo sapiens_hsa041460.72556631
86Phenylalanine metabolism_Homo sapiens_hsa003600.71525339
87Hedgehog signaling pathway_Homo sapiens_hsa043400.71381720
88Tyrosine metabolism_Homo sapiens_hsa003500.70891513
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70787787
90Inositol phosphate metabolism_Homo sapiens_hsa005620.69616089
91Alcoholism_Homo sapiens_hsa050340.68803108
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68313936
93Fatty acid biosynthesis_Homo sapiens_hsa000610.66678050
94Ras signaling pathway_Homo sapiens_hsa040140.66287189
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65282579
96Pancreatic secretion_Homo sapiens_hsa049720.64655939
97Sphingolipid metabolism_Homo sapiens_hsa006000.63995052
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63889363
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63784858
100Wnt signaling pathway_Homo sapiens_hsa043100.62803290
101Homologous recombination_Homo sapiens_hsa034400.62235063
102Protein export_Homo sapiens_hsa030600.61566769
103TGF-beta signaling pathway_Homo sapiens_hsa043500.61216260
104Fatty acid elongation_Homo sapiens_hsa000620.60749951
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59024607
106Renal cell carcinoma_Homo sapiens_hsa052110.57945752
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.56502347
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54995566
109Pyruvate metabolism_Homo sapiens_hsa006200.54343729
110Melanoma_Homo sapiens_hsa052180.52563154
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51410990
112RNA polymerase_Homo sapiens_hsa030200.50347053
113Ether lipid metabolism_Homo sapiens_hsa005650.48739745
114Rap1 signaling pathway_Homo sapiens_hsa040150.47827746
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47538794
116Glucagon signaling pathway_Homo sapiens_hsa049220.47375640
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45855042
118Arginine and proline metabolism_Homo sapiens_hsa003300.45641676
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45109447
120Mineral absorption_Homo sapiens_hsa049780.44924364
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44864505
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44788374
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44677813
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44250258
125Metabolic pathways_Homo sapiens_hsa011000.44202978
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43907826
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43685608
128Tight junction_Homo sapiens_hsa045300.43231928
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40109445
130Type I diabetes mellitus_Homo sapiens_hsa049400.36019183
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.35705880
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34970836
133Non-small cell lung cancer_Homo sapiens_hsa052230.31832047
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31273258
135VEGF signaling pathway_Homo sapiens_hsa043700.30721673
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29912079
137Alzheimers disease_Homo sapiens_hsa050100.29395067
138Basal cell carcinoma_Homo sapiens_hsa052170.27796620
139ECM-receptor interaction_Homo sapiens_hsa045120.25104352
140Hippo signaling pathway_Homo sapiens_hsa043900.25092181
141Phagosome_Homo sapiens_hsa041450.24283610
142Endocytosis_Homo sapiens_hsa041440.23296277

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