LMNA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.83655498
2skin morphogenesis (GO:0043589)5.78374588
3collagen fibril organization (GO:0030199)5.67662771
4protein heterotrimerization (GO:0070208)5.20325972
5Golgi transport vesicle coating (GO:0048200)5.11303028
6COPI coating of Golgi vesicle (GO:0048205)5.11303028
7chondrocyte proliferation (GO:0035988)5.09790073
8barbed-end actin filament capping (GO:0051016)4.89488805
9wound healing, spreading of epidermal cells (GO:0035313)4.69385439
10protein localization to endosome (GO:0036010)4.49868474
11endodermal cell differentiation (GO:0035987)4.37585807
12desmosome organization (GO:0002934)4.28236808
13negative regulation of fatty acid transport (GO:2000192)4.05902753
14wound healing, spreading of cells (GO:0044319)3.89604595
15collagen metabolic process (GO:0032963)3.87212492
16sequestering of extracellular ligand from receptor (GO:0035581)3.82217263
17cell adhesion mediated by integrin (GO:0033627)3.80616914
18collagen catabolic process (GO:0030574)3.71731217
19bone trabecula formation (GO:0060346)3.69797324
20endothelial cell morphogenesis (GO:0001886)3.68395633
21cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.68300317
22positive regulation of endothelial cell apoptotic process (GO:2000353)3.65080359
23multicellular organismal macromolecule metabolic process (GO:0044259)3.58802320
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.58338302
25atrioventricular valve morphogenesis (GO:0003181)3.53663716
26dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.47987012
27extracellular matrix disassembly (GO:0022617)3.45670596
28cell-substrate junction assembly (GO:0007044)3.43811887
29multicellular organismal metabolic process (GO:0044236)3.41004702
30multicellular organismal catabolic process (GO:0044243)3.40719471
31protein maturation by protein folding (GO:0022417)3.36557703
32apoptotic cell clearance (GO:0043277)3.34939481
33basement membrane organization (GO:0071711)3.33270525
34endothelial cell chemotaxis (GO:0035767)3.32083560
35adherens junction assembly (GO:0034333)3.31479988
36retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.31368330
37positive regulation of osteoblast proliferation (GO:0033690)3.29789773
38regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.29588732
39pinocytosis (GO:0006907)3.27435430
40adhesion of symbiont to host (GO:0044406)3.27190757
41plasma membrane repair (GO:0001778)3.26726192
42hypotonic response (GO:0006971)3.24626973
43virion attachment to host cell (GO:0019062)3.24285370
44adhesion of symbiont to host cell (GO:0044650)3.24285370
45maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.24054347
46epithelial cell-cell adhesion (GO:0090136)3.22846446
47cell-substrate adherens junction assembly (GO:0007045)3.22751467
48focal adhesion assembly (GO:0048041)3.22751467
49regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.20432810
50regulation of integrin-mediated signaling pathway (GO:2001044)3.12350382
51keratan sulfate catabolic process (GO:0042340)3.09903612
52peptidyl-proline hydroxylation (GO:0019511)3.09427686
53regulation of early endosome to late endosome transport (GO:2000641)3.08316543
54negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.07204621
55cytoskeletal anchoring at plasma membrane (GO:0007016)3.06582483
56protein retention in ER lumen (GO:0006621)3.05102087
57dermatan sulfate biosynthetic process (GO:0030208)3.04869607
58notochord development (GO:0030903)3.02763422
59mesenchymal-epithelial cell signaling (GO:0060638)3.02263969
60actin filament depolymerization (GO:0030042)3.00231619
61semaphorin-plexin signaling pathway (GO:0071526)2.99328987
62fibril organization (GO:0097435)2.98499819
63type B pancreatic cell proliferation (GO:0044342)2.98392506
64chondrocyte development (GO:0002063)2.97896415
65positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.97194570
66positive regulation of p38MAPK cascade (GO:1900745)2.95914530
67substrate-dependent cell migration (GO:0006929)2.95600521
68extracellular fibril organization (GO:0043206)2.95065893
69membrane raft organization (GO:0031579)2.94904075
70vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.94172472
71positive regulation of epithelial to mesenchymal transition (GO:0010718)2.94169848
72muscle cell migration (GO:0014812)2.93822671
73hyaluronan catabolic process (GO:0030214)2.93457323
74positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.90192726
75cellular response to interferon-alpha (GO:0035457)2.88345571
76heart valve morphogenesis (GO:0003179)2.88316962
77extracellular matrix organization (GO:0030198)2.87714058
78middle ear morphogenesis (GO:0042474)2.87457636
79extracellular structure organization (GO:0043062)2.86356075
80regulation of tight junction assembly (GO:2000810)2.86284704
81positive regulation of blood vessel endothelial cell migration (GO:0043536)2.85626488
82positive regulation of extracellular matrix organization (GO:1903055)2.85164407
83low-density lipoprotein particle clearance (GO:0034383)2.84036402
84regulation of metalloenzyme activity (GO:0048552)2.83450510
85negative regulation of chondrocyte differentiation (GO:0032331)2.82465565
86retina vasculature morphogenesis in camera-type eye (GO:0061299)2.81545868
87regulation of extracellular matrix disassembly (GO:0010715)2.80772446
88positive regulation of receptor recycling (GO:0001921)2.80055543
89cell migration involved in heart development (GO:0060973)2.77597292
90keratinocyte proliferation (GO:0043616)2.77109338
91cellular response to vitamin (GO:0071295)2.76282888
92endocytic recycling (GO:0032456)2.75222173
93positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.73677262
94mesodermal cell differentiation (GO:0048333)2.73674644
95wound healing (GO:0042060)2.72634584
96stress fiber assembly (GO:0043149)2.72500604
97extracellular matrix assembly (GO:0085029)2.71331753
98negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.71118437
99metanephric mesenchyme development (GO:0072075)2.70316106
100neuron projection extension involved in neuron projection guidance (GO:1902284)2.70213356
101axon extension involved in axon guidance (GO:0048846)2.70213356
102regulation of p38MAPK cascade (GO:1900744)2.69651201
103glial cell migration (GO:0008347)2.69564717
104protein hydroxylation (GO:0018126)2.69304378
105dermatan sulfate metabolic process (GO:0030205)2.67993184
106mRNA transcription (GO:0009299)2.67649624
107branching involved in salivary gland morphogenesis (GO:0060445)2.67301060
108endocardial cushion development (GO:0003197)2.66859847
109vascular endothelial growth factor signaling pathway (GO:0038084)2.65182165
110positive regulation of cartilage development (GO:0061036)2.63845955
111peptide cross-linking (GO:0018149)2.63738480
112protein localization to cell surface (GO:0034394)2.63441139
113negative regulation of cartilage development (GO:0061037)2.63092364
114activation of Rac GTPase activity (GO:0032863)2.62019801
115outer ear morphogenesis (GO:0042473)2.60906773
116regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.60159627
117substrate adhesion-dependent cell spreading (GO:0034446)2.60097035
118cellular response to vitamin D (GO:0071305)2.59496891
119UV protection (GO:0009650)2.58947936
120cortical actin cytoskeleton organization (GO:0030866)2.57856236
121membrane protein ectodomain proteolysis (GO:0006509)2.56038558
122regulation of water loss via skin (GO:0033561)2.55641466
123negative regulation of anoikis (GO:2000811)2.55607617
124negative regulation of cell size (GO:0045792)2.55284483
125regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.54728504
126negative regulation of smooth muscle cell migration (GO:0014912)2.54282011
127regulation of cartilage development (GO:0061035)2.53609128
128glomerular basement membrane development (GO:0032836)2.53144990
129positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.52976614
130embryonic cranial skeleton morphogenesis (GO:0048701)2.52498875
131negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.52178966
132actin filament bundle assembly (GO:0051017)2.51998009
133actin filament bundle organization (GO:0061572)2.51998009
134epithelial to mesenchymal transition (GO:0001837)2.51719080
135lymphangiogenesis (GO:0001946)2.51262374
136kidney mesenchyme development (GO:0072074)2.51202330
137craniofacial suture morphogenesis (GO:0097094)2.50800160
138cell migration involved in sprouting angiogenesis (GO:0002042)2.49092815
139iron ion import (GO:0097286)2.48770075
140cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.48615557
141response to progesterone (GO:0032570)2.48091285
142embryo implantation (GO:0007566)2.47888011
143embryonic skeletal joint morphogenesis (GO:0060272)2.47886277
144branching involved in mammary gland duct morphogenesis (GO:0060444)2.46755823
145blood vessel endothelial cell migration (GO:0043534)2.45984878
146planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45753216
147cardiac epithelial to mesenchymal transition (GO:0060317)2.43318210
148protein targeting to plasma membrane (GO:0072661)2.43226311
149positive regulation of odontogenesis (GO:0042482)2.43210313
150regulation of apoptotic process involved in morphogenesis (GO:1902337)2.42993795
151glomerular visceral epithelial cell development (GO:0072015)2.40656901

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.80656747
2TRIM28_21343339_ChIP-Seq_HEK293_Human6.08272351
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.55243787
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.50545226
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.09167901
6HIF1A_21447827_ChIP-Seq_MCF-7_Human2.78376351
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77125284
8* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.69655496
9* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.66487525
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.60295055
11* CLOCK_20551151_ChIP-Seq_293T_Human2.52744865
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.45931739
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.41161227
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.41161227
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.33730262
16* CJUN_26792858_Chip-Seq_BT549_Human2.27091059
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26722235
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.22613888
19CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.18683168
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.15135235
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.05907635
22* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.96956275
23CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.92181932
24* ELK3_25401928_ChIP-Seq_HUVEC_Human1.92141065
25* BRD4_25478319_ChIP-Seq_HGPS_Human1.84605480
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.84196456
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83003874
28* ATF3_27146783_Chip-Seq_COLON_Human1.82300304
29* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.80356184
30P63_26484246_Chip-Seq_KERATINOCYTES_Human1.78030097
31* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74801460
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70835074
33* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67949310
34VDR_21846776_ChIP-Seq_THP-1_Human1.67274816
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.66923108
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65027796
37* UBF1/2_26484160_Chip-Seq_HMECs_Human1.63896081
38* SOX2_20726797_ChIP-Seq_SW620_Human1.62399508
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.60117205
40* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59399662
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57253995
42* RACK7_27058665_Chip-Seq_MCF-7_Human1.54291201
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50854830
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50167342
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49612993
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.47050312
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.47050312
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.47050312
49* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46130116
50* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46130116
51HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.42679906
52* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41931141
53* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39199002
54SMC1_22415368_ChIP-Seq_MEFs_Mouse1.39133569
55* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37289356
56TP53_18474530_ChIP-ChIP_U2OS_Human1.36583155
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36255236
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36207434
59* GATA2_21666600_ChIP-Seq_HMVEC_Human1.35072654
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.34044244
61* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33167561
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32516593
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.32130067
64* TP53_22127205_ChIP-Seq_IMR90_Human1.29844655
65ZNF263_19887448_ChIP-Seq_K562_Human1.28224546
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27973187
67* TCF7_22412390_ChIP-Seq_EML_Mouse1.26572052
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26280231
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23634203
70KDM2B_26808549_Chip-Seq_DND41_Human1.23026997
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23021145
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.20646441
73* KLF5_25053715_ChIP-Seq_YYC3_Human1.20619238
74* TET1_21451524_ChIP-Seq_MESCs_Mouse1.19757221
75NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16177976
76* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16139443
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15897359
78* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15817282
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15570835
80* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14452151
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13149173
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.10533175
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10201620
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06826323
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.06110467
86CDX2_20551321_ChIP-Seq_CACO-2_Human1.05484783
87MYC_22102868_ChIP-Seq_BL_Human1.04845465
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04452001
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04439144
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04416858
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03552707
92TP53_16413492_ChIP-PET_HCT116_Human1.03247799
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03058917
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02220464
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01908213
96* RXR_22158963_ChIP-Seq_LIVER_Mouse1.01898303
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01339201
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00753644
99FOXM1_23109430_ChIP-Seq_U2OS_Human1.00205419
100* TP53_23651856_ChIP-Seq_MEFs_Mouse1.00062489
101VDR_24763502_ChIP-Seq_THP-1_Human0.99502456
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99276977
103* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98720500
104* SA1_27219007_Chip-Seq_ERYTHROID_Human0.98060581
105NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97997869
106* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97459858
107* KDM2B_26808549_Chip-Seq_JURKAT_Human0.95668640
108* TBX20_22080862_ChIP-Seq_HEART_Mouse0.95545881
109* TBX20_22328084_ChIP-Seq_HEART_Mouse0.95545881
110GATA3_24758297_ChIP-Seq_MCF-7_Human0.95472894
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95403082
112PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94589972
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94120359
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94048650
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92263659
116P68_20966046_ChIP-Seq_HELA_Human0.91736586
117CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91491641
118BP1_19119308_ChIP-ChIP_Hs578T_Human0.91011237
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91006099
120SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90733455
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90676611
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89970668
123* KDM2B_26808549_Chip-Seq_K562_Human0.87404330
124LXR_22292898_ChIP-Seq_THP-1_Human0.86927880
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86412347
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85644963
127RXR_22108803_ChIP-Seq_LS180_Human0.85388629
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.84658823
129FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84290901
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83208067
131* TP63_23658742_ChIP-Seq_EP156T_Human0.83164790
132GATA6_25053715_ChIP-Seq_YYC3_Human0.82795242
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82372331
134NCOR1_26117541_ChIP-Seq_K562_Human0.81274939
135MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.78919956
136BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76478336
137FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76303396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.38281685
2MP0005275_abnormal_skin_tensile5.01304425
3MP0003705_abnormal_hypodermis_morpholog4.55266286
4MP0005503_abnormal_tendon_morphology3.77759095
5MP0003279_aneurysm3.11356625
6MP0003566_abnormal_cell_adhesion2.79967053
7* MP0002060_abnormal_skin_morphology2.60865743
8MP0005058_abnormal_lysosome_morphology2.54286990
9MP0004272_abnormal_basement_membrane2.52359120
10MP0001958_emphysema2.52112144
11MP0005257_abnormal_intraocular_pressure2.42607759
12MP0009840_abnormal_foam_cell2.25680701
13MP0003191_abnormal_cellular_cholesterol2.16054793
14MP0005023_abnormal_wound_healing2.15886505
15* MP0005508_abnormal_skeleton_morphology2.05755544
16MP0010352_gastrointestinal_tract_polyps2.04863633
17MP0005623_abnormal_meninges_morphology2.04714324
18MP0002796_impaired_skin_barrier1.92393689
19MP0009384_cardiac_valve_regurgitation1.92266326
20MP0003941_abnormal_skin_development1.92238659
21MP0003091_abnormal_cell_migration1.92061085
22MP0000750_abnormal_muscle_regeneration1.85470650
23MP0000733_abnormal_muscle_development1.76039298
24MP0004858_abnormal_nervous_system1.72069915
25MP0006054_spinal_hemorrhage1.70239077
26* MP0001243_abnormal_dermal_layer1.63216101
27MP0002254_reproductive_system_inflammat1.62277626
28* MP0009250_abnormal_appendicular_skeleto1.59218286
29MP0010368_abnormal_lymphatic_system1.51872925
30MP0005451_abnormal_body_composition1.50843888
31MP0002282_abnormal_trachea_morphology1.50810953
32* MP0000762_abnormal_tongue_morphology1.49717436
33MP0005501_abnormal_skin_physiology1.45019814
34MP0000163_abnormal_cartilage_morphology1.42946656
35* MP0002896_abnormal_bone_mineralization1.41891283
36* MP0001542_abnormal_bone_strength1.41261844
37MP0003453_abnormal_keratinocyte_physiol1.41218421
38MP0005076_abnormal_cell_differentiation1.40094364
39MP0002933_joint_inflammation1.38902811
40* MP0005390_skeleton_phenotype1.38263811
41MP0002108_abnormal_muscle_morphology1.38171896
42MP0000767_abnormal_smooth_muscle1.38140153
43MP0009053_abnormal_anal_canal1.37661349
44MP0003950_abnormal_plasma_membrane1.34558476
45MP0003385_abnormal_body_wall1.31877049
46MP0009780_abnormal_chondrocyte_physiolo1.28147975
47* MP0010030_abnormal_orbit_morphology1.24971193
48MP0004233_abnormal_muscle_weight1.24191219
49* MP0002877_abnormal_melanocyte_morpholog1.21096040
50MP0004510_myositis1.20880472
51MP0008260_abnormal_autophagy1.19777805
52* MP0001216_abnormal_epidermal_layer1.19618372
53MP0009379_abnormal_foot_pigmentation1.19509341
54MP0005165_increased_susceptibility_to1.19469411
55MP0000343_altered_response_to1.19296663
56MP0002295_abnormal_pulmonary_circulatio1.18175374
57MP0002115_abnormal_skeleton_extremities1.16732099
58* MP0003755_abnormal_palate_morphology1.16146470
59* MP0010771_integument_phenotype1.14511456
60MP0005595_abnormal_vascular_smooth1.13034409
61MP0003045_fibrosis1.11158121
62MP0005409_darkened_coat_color1.11051849
63MP0002113_abnormal_skeleton_development1.09484396
64MP0005171_absent_coat_pigmentation1.09482753
65MP0000467_abnormal_esophagus_morphology1.08670484
66MP0001533_abnormal_skeleton_physiology1.06101359
67MP0004134_abnormal_chest_morphology1.05223128
68MP0003300_gastrointestinal_ulcer1.04466363
69MP0003828_pulmonary_edema1.03244408
70MP0000579_abnormal_nail_morphology1.03226264
71MP0001348_abnormal_lacrimal_gland1.03120612
72MP0000049_abnormal_middle_ear1.01577634
73MP0002998_abnormal_bone_remodeling0.98930276
74MP0001879_abnormal_lymphatic_vessel0.98696982
75MP0000013_abnormal_adipose_tissue0.98611987
76MP0004185_abnormal_adipocyte_glucose0.97907480
77MP0000428_abnormal_craniofacial_morphol0.97863169
78MP0000858_altered_metastatic_potential0.97731386
79MP0010234_abnormal_vibrissa_follicle0.95774715
80MP0005375_adipose_tissue_phenotype0.95478218
81MP0002932_abnormal_joint_morphology0.93575866
82MP0001346_abnormal_lacrimal_gland0.93013829
83MP0003942_abnormal_urinary_system0.91250082
84* MP0001299_abnormal_eye_distance/0.91012566
85* MP0000377_abnormal_hair_follicle0.90949249
86MP0000751_myopathy0.90415188
87MP0006138_congestive_heart_failure0.90121004
88* MP0003795_abnormal_bone_structure0.89381745
89MP0002098_abnormal_vibrissa_morphology0.89302223
90MP0003448_altered_tumor_morphology0.87972053
91* MP0000432_abnormal_head_morphology0.86958104
92MP0005197_abnormal_uvea_morphology0.86250400
93MP0000383_abnormal_hair_follicle0.84768010
94MP0003329_amyloid_beta_deposits0.84465502
95MP0001849_ear_inflammation0.83247690
96MP0002234_abnormal_pharynx_morphology0.81617407
97MP0002109_abnormal_limb_morphology0.79991387
98MP0001191_abnormal_skin_condition0.79700181
99MP0002168_other_aberrant_phenotype0.79682036
100MP0004947_skin_inflammation0.79532207
101MP0005164_abnormal_response_to0.79255127
102MP0005621_abnormal_cell_physiology0.79051169
103MP0003303_peritoneal_inflammation0.78276305
104* MP0009931_abnormal_skin_appearance0.78220101
105* MP0000759_abnormal_skeletal_muscle0.78117197
106MP0003075_altered_response_to0.77886323
107MP0003172_abnormal_lysosome_physiology0.77616278
108MP0005360_urolithiasis0.77396624
109MP0001915_intracranial_hemorrhage0.77043525
110* MP0004087_abnormal_muscle_fiber0.76426200
111MP0002233_abnormal_nose_morphology0.75563907
112MP0002249_abnormal_larynx_morphology0.74658302
113MP0002089_abnormal_postnatal_growth/wei0.74367394
114MP0000516_abnormal_urinary_system0.73500164
115MP0005367_renal/urinary_system_phenotyp0.73500164
116MP0000534_abnormal_ureter_morphology0.73267522
117MP0001614_abnormal_blood_vessel0.72122146
118MP0003935_abnormal_craniofacial_develop0.71733016
119* MP0000749_muscle_degeneration0.71700360
120MP0000627_abnormal_mammary_gland0.71509843
121MP0005666_abnormal_adipose_tissue0.70721124
122MP0000249_abnormal_blood_vessel0.70594259
123MP0000003_abnormal_adipose_tissue0.70462036
124MP0002128_abnormal_blood_circulation0.70306957
125MP0003937_abnormal_limbs/digits/tail_de0.70164326
126* MP0002116_abnormal_craniofacial_bone0.69816897
127MP0005248_abnormal_Harderian_gland0.69086778
128MP0000537_abnormal_urethra_morphology0.69041338
129* MP0002111_abnormal_tail_morphology0.68938299
130* MP0005330_cardiomyopathy0.68795022
131MP0001661_extended_life_span0.68532503
132MP0001853_heart_inflammation0.67726884
133MP0005193_abnormal_anterior_eye0.65812386
134MP0005670_abnormal_white_adipose0.60479645

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.76843721
2* Premature rupture of membranes (HP:0001788)6.39579141
3Atrophic scars (HP:0001075)5.09115958
4Fragile skin (HP:0001030)4.41338842
5Neonatal short-limb short stature (HP:0008921)4.10663718
6Ankle contracture (HP:0006466)3.88332529
7Peritonitis (HP:0002586)3.87749688
8Soft skin (HP:0000977)3.85684522
9Aortic dissection (HP:0002647)3.84958959
10Shallow orbits (HP:0000586)3.64209220
11Vertebral compression fractures (HP:0002953)3.56730158
12Type 1 muscle fiber predominance (HP:0003803)3.44292550
13Cervical subluxation (HP:0003308)3.39867817
14Cerebral aneurysm (HP:0004944)3.29892300
15Follicular hyperkeratosis (HP:0007502)3.23028612
16* Increased connective tissue (HP:0009025)3.18017758
17Abnormality of dentin (HP:0010299)3.15750095
18Aortic aneurysm (HP:0004942)3.12724500
19* Spinal rigidity (HP:0003306)3.10335279
20Genu recurvatum (HP:0002816)3.10281467
21Alopecia of scalp (HP:0002293)2.97858078
22Arterial tortuosity (HP:0005116)2.96078752
23Blue sclerae (HP:0000592)2.90077453
24Hyperacusis (HP:0010780)2.89971092
25Broad face (HP:0000283)2.88916264
26Biconcave vertebral bodies (HP:0004586)2.87144161
27Mitral valve prolapse (HP:0001634)2.85463052
28Cupped ribs (HP:0000887)2.80428904
29Bladder diverticulum (HP:0000015)2.80261287
30* Dilatation of the ascending aorta (HP:0005111)2.79757943
31Milia (HP:0001056)2.76434922
32* Wormian bones (HP:0002645)2.75550145
33Abnormality of the acetabulum (HP:0003170)2.57556237
34Right ventricular cardiomyopathy (HP:0011663)2.56060332
35Broad metatarsal (HP:0001783)2.50398706
36* Mildly elevated creatine phosphokinase (HP:0008180)2.50238681
37Spondylolisthesis (HP:0003302)2.44635795
38Flat acetabular roof (HP:0003180)2.44192750
39Hypoplastic ischia (HP:0003175)2.44162515
40Overgrowth (HP:0001548)2.42151401
41Epiphyseal dysplasia (HP:0002656)2.38825147
42Slender build (HP:0001533)2.35910246
43Hand muscle atrophy (HP:0009130)2.33090568
44Nuclear cataract (HP:0100018)2.32616028
45Round ear (HP:0100830)2.31755635
46Coxa vara (HP:0002812)2.31140790
47Abnormality of glycolipid metabolism (HP:0010969)2.31024144
48Abnormality of liposaccharide metabolism (HP:0010968)2.31024144
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.31024144
50Wrist flexion contracture (HP:0001239)2.30181191
51Increased variability in muscle fiber diameter (HP:0003557)2.28904500
52Osteoarthritis (HP:0002758)2.28492733
53Aortic regurgitation (HP:0001659)2.27801982
54Dysostosis multiplex (HP:0000943)2.27615383
55Increased density of long bones (HP:0006392)2.25874295
56Axonal loss (HP:0003447)2.25838940
57Hyperextensible skin (HP:0000974)2.24684926
58Muscle fiber splitting (HP:0003555)2.24597622
59Upper limb amyotrophy (HP:0009129)2.23703749
60Distal upper limb amyotrophy (HP:0007149)2.23703749
61Fragile nails (HP:0001808)2.22382382
62Pterygium (HP:0001059)2.22253112
63Thick nail (HP:0001805)2.21409263
64Interstitial pulmonary disease (HP:0006530)2.19898011
65Long toe (HP:0010511)2.18948408
66Abnormality of the ischium (HP:0003174)2.18003189
67Wide anterior fontanel (HP:0000260)2.17534661
68Mitral stenosis (HP:0001718)2.17531554
69Mesomelia (HP:0003027)2.17063166
70Abnormality of skeletal muscle fiber size (HP:0012084)2.16638011
71Cardiovascular calcification (HP:0011915)2.15139271
72Syringomyelia (HP:0003396)2.12849044
73Spinal cord lesions (HP:0100561)2.12849044
74Thin ribs (HP:0000883)2.12195832
75Ulnar bowing (HP:0003031)2.11389386
76Tibial bowing (HP:0002982)2.09608159
77Thin bony cortex (HP:0002753)2.08813803
78Spinal cord compression (HP:0002176)2.08326628
79Abnormality of the calcaneus (HP:0008364)2.05273432
80* Elbow flexion contracture (HP:0002987)2.04896324
81J-shaped sella turcica (HP:0002680)2.04402346
82Absent frontal sinuses (HP:0002688)2.04125944
83Disproportionate tall stature (HP:0001519)2.03952976
84Trismus (HP:0000211)2.03946020
85Abnormality of the 2nd finger (HP:0004100)2.03784375
86Thoracolumbar scoliosis (HP:0002944)2.03210286
87Abnormal vertebral ossification (HP:0100569)2.02191794
88Breech presentation (HP:0001623)2.01694801
89Vascular tortuosity (HP:0004948)2.00231893
90* Difficulty climbing stairs (HP:0003551)1.99398334
91Insomnia (HP:0100785)1.98882922
92* Mitral regurgitation (HP:0001653)1.98665707
93Platyspondyly (HP:0000926)1.98207929
94Mucopolysacchariduria (HP:0008155)1.96906391
95Urinary glycosaminoglycan excretion (HP:0003541)1.96906391
96* Distal lower limb amyotrophy (HP:0008944)1.96719616
97* Abnormal delivery (HP:0001787)1.96192553
98Aplasia/Hypoplasia of the scapulae (HP:0006713)1.95598695
99Hypoplastic scapulae (HP:0000882)1.95598695
100* Achilles tendon contracture (HP:0001771)1.91992355
101Stridor (HP:0010307)1.91530717
102Radial bowing (HP:0002986)1.90791067
103Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90003765
104Abnormality of polysaccharide metabolism (HP:0011012)1.90003765
105Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90003765
106Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.89921750
107Abnormal ossification of hand bones (HP:0005921)1.89566246
108Bowel diverticulosis (HP:0005222)1.89363328
109Deviation of the hallux (HP:0010051)1.89000367
110Knee flexion contracture (HP:0006380)1.88373615
111Joint laxity (HP:0001388)1.87454110
112* Distal lower limb muscle weakness (HP:0009053)1.86402603
113Bowed forearm bones (HP:0003956)1.86020132
114Bowing of the arm (HP:0006488)1.86020132
115Bronchomalacia (HP:0002780)1.85047202
116Aneurysm (HP:0002617)1.84999854
117* Generalized amyotrophy (HP:0003700)1.84698589
118Beaking of vertebral bodies (HP:0004568)1.84557107
119Plantar hyperkeratosis (HP:0007556)1.84365409
120Nonimmune hydrops fetalis (HP:0001790)1.84017876
121Fused cervical vertebrae (HP:0002949)1.83465809
122Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83314570
123Hip contracture (HP:0003273)1.83053457
124Abnormality of carpal bone ossification (HP:0006257)1.82604845
125Infantile muscular hypotonia (HP:0008947)1.82216944
126Centrally nucleated skeletal muscle fibers (HP:0003687)1.80960980
127* Joint stiffness (HP:0001387)1.79871284
128* Short nail (HP:0001799)1.79168746
129Mild short stature (HP:0003502)1.79163723
130Femoral bowing (HP:0002980)1.78670020
131* Osteolytic defects of the hand bones (HP:0009699)1.78594613
132* Osteolytic defects of the phalanges of the hand (HP:0009771)1.78594613
133Onycholysis (HP:0001806)1.77936187
134Hallux valgus (HP:0001822)1.77692679
135Fatigable weakness (HP:0003473)1.76784400
136Abnormality of the neuromuscular junction (HP:0003398)1.76784400
137Camptodactyly of toe (HP:0001836)1.76404914
138Abnormal foot bone ossification (HP:0010675)1.75886240
139Selective tooth agenesis (HP:0001592)1.75362112
140Back pain (HP:0003418)1.71921407
141Vascular calcification (HP:0004934)1.71518884
142Protruding ear (HP:0000411)1.68482311
143Aortic valve stenosis (HP:0001650)1.68313187
144* Abnormality of the Achilles tendon (HP:0005109)1.66582199
145Ulnar deviation of the wrist (HP:0003049)1.66051525
146Asymmetric septal hypertrophy (HP:0001670)1.61915626
147Nail dystrophy (HP:0008404)1.60337950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.60817819
2DDR23.60185127
3TTN3.49775822
4MAP3K33.17032636
5IRAK33.04133658
6ERN12.88318509
7EPHA22.79858739
8PIM22.53789760
9FER2.43047178
10TRPM72.35794848
11MOS2.26081689
12LMTK22.20442512
13EPHB22.18089023
14LATS12.14385441
15LATS22.06973919
16EPHA32.05721225
17PDGFRA2.01129540
18ICK2.00998965
19BMX1.95801549
20MST1R1.91872162
21TESK11.90011564
22PKN21.82892163
23SMG11.76815648
24PRPF4B1.69997115
25RIPK11.69255539
26NME21.65356792
27LIMK11.63892849
28RPS6KA41.59772712
29PAK21.56585611
30NTRK11.46991146
31MAPKAPK31.42910027
32MET1.37152822
33PTK21.35481625
34TGFBR21.35002133
35STK38L1.34261246
36EPHB11.31306658
37ARAF1.28066599
38ERBB31.27682732
39NEK91.23450983
40LRRK21.20895304
41ZAK1.20823475
42STK101.20199197
43FGFR41.17746540
44PAK41.16846273
45SIK11.16787223
46DMPK1.15230437
47PTK61.12932330
48PRKG21.10982547
49PIK3CG1.10133781
50FRK1.09695194
51MAP2K11.07964595
52MAP2K31.05153472
53STK31.04871419
54MAP3K61.03566490
55CDC42BPA1.00983968
56SCYL20.99495800
57MAP3K110.99234119
58EEF2K0.98779501
59TAOK10.98722477
60ROCK10.92801103
61TESK20.88027795
62ILK0.87016976
63CDK120.79126440
64CDK60.78206271
65FLT30.77784745
66RPS6KA20.76980159
67MAP2K20.75389066
68STK380.74972108
69MTOR0.72595412
70RPS6KB20.72551822
71PDGFRB0.72361618
72DYRK1B0.71920313
73PIK3CA0.71335859
74MAPKAPK20.69720154
75PTK2B0.69461892
76TAOK20.68977852
77PAK30.66707433
78NUAK10.61080669
79TBK10.58664501
80CDK80.57864298
81TGFBR10.57718107
82ZAP700.57505578
83ABL20.57222990
84FGFR10.55217368
85STK240.53803115
86PDK20.52869402
87MST40.52265277
88IKBKB0.51546988
89MAPKAPK50.50354213
90PAK10.49119748
91PDPK10.48408592
92MAP3K130.46853560
93BRAF0.46725410
94INSR0.45605242
95HIPK20.44806474
96FGFR30.44583301
97PRKD10.44491363
98GSK3A0.43421496
99MAPK110.42461859
100MAP3K80.42364313
101ERBB20.42074238
102MAP3K20.41693467
103CAMK2G0.41381353
104BUB10.40990533
105DAPK30.40843706
106MAP3K100.40215643
107MELK0.38991458
108ADRBK10.38576046
109PRKD20.38268061
110ROCK20.38101744
111CHUK0.37851400
112CDK70.35800626
113KDR0.34842712
114MAPK70.34689473
115CSK0.34170623
116ERBB40.33073419
117CDK90.32510492
118RPS6KL10.31309298
119RPS6KC10.31309298
120PAK60.30823652
121NLK0.30607160
122AKT20.29710630
123AURKB0.29646107
124MAP3K140.29263730
125ABL10.29233896
126MAP3K10.29205474
127MARK20.27952903
128AURKA0.27512584
129MYLK0.27166657
130PIM10.26779776
131PBK0.26728079
132KSR20.26407503

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.22486510
2Focal adhesion_Homo sapiens_hsa045102.83301443
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.71494460
4Bladder cancer_Homo sapiens_hsa052192.51188885
5Proteoglycans in cancer_Homo sapiens_hsa052052.46615588
6Protein digestion and absorption_Homo sapiens_hsa049742.36237616
7Malaria_Homo sapiens_hsa051442.21734224
8Adherens junction_Homo sapiens_hsa045202.09473619
9Amoebiasis_Homo sapiens_hsa051461.98719639
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.93789157
11TGF-beta signaling pathway_Homo sapiens_hsa043501.90830976
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.90064614
13* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.84281617
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.81191824
15Small cell lung cancer_Homo sapiens_hsa052221.79621252
16MicroRNAs in cancer_Homo sapiens_hsa052061.76718077
17Pentose phosphate pathway_Homo sapiens_hsa000301.76570185
18* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.71968862
19Hippo signaling pathway_Homo sapiens_hsa043901.70298075
20Fructose and mannose metabolism_Homo sapiens_hsa000511.53956735
21Prion diseases_Homo sapiens_hsa050201.53738051
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51561009
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.49993696
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.49398279
25p53 signaling pathway_Homo sapiens_hsa041151.48371653
26Chronic myeloid leukemia_Homo sapiens_hsa052201.42895236
27Melanoma_Homo sapiens_hsa052181.42620351
28* Dilated cardiomyopathy_Homo sapiens_hsa054141.42563974
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.40998016
30Basal cell carcinoma_Homo sapiens_hsa052171.39342928
31Vibrio cholerae infection_Homo sapiens_hsa051101.36527592
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36093595
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.33378704
34Shigellosis_Homo sapiens_hsa051311.30425508
35TNF signaling pathway_Homo sapiens_hsa046681.29794321
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26058963
37Toxoplasmosis_Homo sapiens_hsa051451.23318732
38Tight junction_Homo sapiens_hsa045301.23166483
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20651668
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19095388
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16889947
42Viral myocarditis_Homo sapiens_hsa054161.15561635
43Prostate cancer_Homo sapiens_hsa052151.13049401
44Sulfur relay system_Homo sapiens_hsa041221.11163889
45Salmonella infection_Homo sapiens_hsa051321.10643821
46* Apoptosis_Homo sapiens_hsa042101.10023550
47N-Glycan biosynthesis_Homo sapiens_hsa005101.07283758
48Hedgehog signaling pathway_Homo sapiens_hsa043401.06282444
49Biosynthesis of amino acids_Homo sapiens_hsa012301.05041780
50Thyroid cancer_Homo sapiens_hsa052161.04190249
51HTLV-I infection_Homo sapiens_hsa051661.00582638
52Pancreatic cancer_Homo sapiens_hsa052121.00065400
53Phagosome_Homo sapiens_hsa041451.00052198
54Pathways in cancer_Homo sapiens_hsa052000.99827735
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.96056060
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95343882
57Platelet activation_Homo sapiens_hsa046110.94116838
58Arachidonic acid metabolism_Homo sapiens_hsa005900.92107147
59Rap1 signaling pathway_Homo sapiens_hsa040150.89710008
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89556665
61HIF-1 signaling pathway_Homo sapiens_hsa040660.87131057
62Acute myeloid leukemia_Homo sapiens_hsa052210.85150534
63Leishmaniasis_Homo sapiens_hsa051400.84164105
64Legionellosis_Homo sapiens_hsa051340.83145772
65Hepatitis B_Homo sapiens_hsa051610.82746330
66Glioma_Homo sapiens_hsa052140.82571580
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.76923286
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.76229798
69Osteoclast differentiation_Homo sapiens_hsa043800.75346998
70Viral carcinogenesis_Homo sapiens_hsa052030.74852362
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74466689
72Sulfur metabolism_Homo sapiens_hsa009200.73539590
73Non-small cell lung cancer_Homo sapiens_hsa052230.72860792
74Sphingolipid metabolism_Homo sapiens_hsa006000.72692900
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72389261
76Complement and coagulation cascades_Homo sapiens_hsa046100.72098065
77Insulin signaling pathway_Homo sapiens_hsa049100.71923633
78Pertussis_Homo sapiens_hsa051330.71750835
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70125401
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69639277
81Galactose metabolism_Homo sapiens_hsa000520.69267270
82Carbon metabolism_Homo sapiens_hsa012000.67063868
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62318194
84Wnt signaling pathway_Homo sapiens_hsa043100.60890778
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60637117
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60454626
87Renal cell carcinoma_Homo sapiens_hsa052110.60279933
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.59043724
89AMPK signaling pathway_Homo sapiens_hsa041520.58624500
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58502783
91VEGF signaling pathway_Homo sapiens_hsa043700.57575274
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57513074
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57297466
94Notch signaling pathway_Homo sapiens_hsa043300.57262715
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56824878
96Tuberculosis_Homo sapiens_hsa051520.55822405
97ErbB signaling pathway_Homo sapiens_hsa040120.55696807
98Phenylalanine metabolism_Homo sapiens_hsa003600.55652842
99Endocytosis_Homo sapiens_hsa041440.55565437
100Endometrial cancer_Homo sapiens_hsa052130.55523618
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.54766407
102Axon guidance_Homo sapiens_hsa043600.53613612
103Lysosome_Homo sapiens_hsa041420.52739847
104Other glycan degradation_Homo sapiens_hsa005110.52024436
105Chemical carcinogenesis_Homo sapiens_hsa052040.51945096
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51644217
107Ras signaling pathway_Homo sapiens_hsa040140.49051481
108Estrogen signaling pathway_Homo sapiens_hsa049150.48084742
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48037922
110Hematopoietic cell lineage_Homo sapiens_hsa046400.47959442
111FoxO signaling pathway_Homo sapiens_hsa040680.47543179
112Hepatitis C_Homo sapiens_hsa051600.47166846
113mTOR signaling pathway_Homo sapiens_hsa041500.45958429
114Melanogenesis_Homo sapiens_hsa049160.45933102
115Prolactin signaling pathway_Homo sapiens_hsa049170.45260146
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.44952723
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.44762859
118Caffeine metabolism_Homo sapiens_hsa002320.44177846
119Starch and sucrose metabolism_Homo sapiens_hsa005000.42963688
120Glutathione metabolism_Homo sapiens_hsa004800.42777106
121Insulin resistance_Homo sapiens_hsa049310.41655351
122Renin-angiotensin system_Homo sapiens_hsa046140.40970107
123Gap junction_Homo sapiens_hsa045400.40750138
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.39044921
125MAPK signaling pathway_Homo sapiens_hsa040100.38755688
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37545084
127GnRH signaling pathway_Homo sapiens_hsa049120.37216237
128Rheumatoid arthritis_Homo sapiens_hsa053230.37184184

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