LMNB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.52447622
2protein localization to kinetochore (GO:0034501)4.85919145
3DNA strand elongation involved in DNA replication (GO:0006271)4.75319623
4DNA strand elongation (GO:0022616)4.49013949
5DNA replication initiation (GO:0006270)4.40747124
6DNA replication-dependent nucleosome organization (GO:0034723)4.35268980
7DNA replication-dependent nucleosome assembly (GO:0006335)4.35268980
8protein localization to chromosome, centromeric region (GO:0071459)4.31938620
9telomere maintenance via semi-conservative replication (GO:0032201)4.29475225
10nuclear pore organization (GO:0006999)4.11164231
11folic acid-containing compound biosynthetic process (GO:0009396)4.09760361
12mitotic sister chromatid segregation (GO:0000070)4.07137303
13viral transcription (GO:0019083)4.05097250
14mitotic nuclear envelope disassembly (GO:0007077)4.03829205
15nuclear pore complex assembly (GO:0051292)3.99173250
16translational termination (GO:0006415)3.94960405
17negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.94087913
18sister chromatid segregation (GO:0000819)3.91437036
19establishment of integrated proviral latency (GO:0075713)3.84971241
20protein complex localization (GO:0031503)3.83630002
21nuclear envelope disassembly (GO:0051081)3.76758908
22membrane disassembly (GO:0030397)3.76758908
23ribosomal small subunit assembly (GO:0000028)3.74531445
24regulation of mammary gland epithelial cell proliferation (GO:0033599)3.74114939
25DNA duplex unwinding (GO:0032508)3.71864133
26maturation of SSU-rRNA (GO:0030490)3.71455916
27DNA geometric change (GO:0032392)3.69964079
28telomere maintenance via recombination (GO:0000722)3.69563516
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.66623781
30mitotic recombination (GO:0006312)3.66127928
31negative regulation of RNA splicing (GO:0033119)3.64124810
32translational elongation (GO:0006414)3.63708038
33COPI coating of Golgi vesicle (GO:0048205)3.62256310
34Golgi transport vesicle coating (GO:0048200)3.62256310
35mitotic sister chromatid cohesion (GO:0007064)3.61913587
36mitotic chromosome condensation (GO:0007076)3.54362781
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54166064
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.54120529
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.50534859
40DNA replication checkpoint (GO:0000076)3.50527379
41peptidyl-arginine omega-N-methylation (GO:0035247)3.50385235
42proline biosynthetic process (GO:0006561)3.50245201
43telomere maintenance via telomere lengthening (GO:0010833)3.46492256
44DNA deamination (GO:0045006)3.46296334
45regulation of posttranscriptional gene silencing (GO:0060147)3.45708391
46regulation of gene silencing by miRNA (GO:0060964)3.45708391
47regulation of gene silencing by RNA (GO:0060966)3.45708391
48cellular protein complex localization (GO:0034629)3.45566712
49translational initiation (GO:0006413)3.45542713
50IMP biosynthetic process (GO:0006188)3.43452160
51regulation of translational termination (GO:0006449)3.42765841
52protein-DNA complex disassembly (GO:0032986)3.41388042
53nucleosome disassembly (GO:0006337)3.41388042
54heterochromatin organization (GO:0070828)3.41243022
55formation of translation preinitiation complex (GO:0001731)3.41167620
56negative regulation of mRNA processing (GO:0050686)3.40176726
57regulation of translational fidelity (GO:0006450)3.39292139
58DNA topological change (GO:0006265)3.38057254
59nucleobase biosynthetic process (GO:0046112)3.36116732
60regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.34287550
61regulation of histone H3-K9 methylation (GO:0051570)3.32356731
62mitotic metaphase plate congression (GO:0007080)3.29637813
63dosage compensation (GO:0007549)3.26892999
64paraxial mesoderm development (GO:0048339)3.26606033
65DNA packaging (GO:0006323)3.25517655
66mRNA stabilization (GO:0048255)3.23213534
67RNA stabilization (GO:0043489)3.23213534
68ribosomal small subunit biogenesis (GO:0042274)3.22079799
69pre-miRNA processing (GO:0031054)3.21944602
70ribosomal large subunit biogenesis (GO:0042273)3.19810068
71cellular protein complex disassembly (GO:0043624)3.19192161
72DNA conformation change (GO:0071103)3.18777219
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16696583
74regulation of RNA export from nucleus (GO:0046831)3.15997726
75chromosome condensation (GO:0030261)3.15996483
76regulation of mitotic spindle organization (GO:0060236)3.15924404
77kinetochore organization (GO:0051383)3.14552996
78spliceosomal tri-snRNP complex assembly (GO:0000244)3.14071006
79termination of RNA polymerase II transcription (GO:0006369)3.13639613
80negative regulation of mRNA metabolic process (GO:1903312)3.13493609
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13143585
82protein complex disassembly (GO:0043241)3.12280451
83spliceosomal snRNP assembly (GO:0000387)3.11996478
84viral life cycle (GO:0019058)3.10242594
85chromatin remodeling at centromere (GO:0031055)3.09752373
86base-excision repair (GO:0006284)3.09674391
87negative regulation of chromosome segregation (GO:0051985)3.09059858
88positive regulation of chromosome segregation (GO:0051984)3.08342060
89regulation of chromosome segregation (GO:0051983)3.08072987
90protein targeting to ER (GO:0045047)3.06815648
91chromatin assembly or disassembly (GO:0006333)3.06157206
92cotranslational protein targeting to membrane (GO:0006613)3.05302764
93adherens junction assembly (GO:0034333)3.03553071
94mRNA splicing, via spliceosome (GO:0000398)3.02124504
95RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.02124504
96somatic hypermutation of immunoglobulin genes (GO:0016446)3.01825371
97somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01825371
98DNA replication-independent nucleosome organization (GO:0034724)3.01768468
99DNA replication-independent nucleosome assembly (GO:0006336)3.01768468
100histone arginine methylation (GO:0034969)3.01021150
101protein localization to chromosome (GO:0034502)3.00682184
102regulation of spindle organization (GO:0090224)3.00187360
103translesion synthesis (GO:0019985)2.99859276
104ribonucleoprotein complex biogenesis (GO:0022613)2.99673408
105RNA splicing, via transesterification reactions (GO:0000375)2.98980435
106nuclear envelope organization (GO:0006998)2.98699215
107activation of Rac GTPase activity (GO:0032863)2.97126706
108CENP-A containing nucleosome assembly (GO:0034080)2.96761055
109peptidyl-arginine N-methylation (GO:0035246)2.96045799
110peptidyl-arginine methylation (GO:0018216)2.96045799
111IMP metabolic process (GO:0046040)2.95798145
112negative regulation of mitotic sister chromatid separation (GO:2000816)2.95321755
113negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95321755
114negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95321755
115negative regulation of sister chromatid segregation (GO:0033046)2.95321755
116pore complex assembly (GO:0046931)2.95292718
117negative regulation of histone methylation (GO:0031061)2.94718823
118positive regulation of DNA-dependent DNA replication (GO:2000105)2.94216832
119chromatin assembly (GO:0031497)2.93041808
120establishment of viral latency (GO:0019043)2.92096961
121ribosome biogenesis (GO:0042254)2.91154489
122regulation of sister chromatid cohesion (GO:0007063)2.90846087
123macromolecular complex disassembly (GO:0032984)2.90547662
124establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90431557
125maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87080204
126protein export from nucleus (GO:0006611)2.86782272
127focal adhesion assembly (GO:0048041)2.86638205
128cell-substrate adherens junction assembly (GO:0007045)2.86638205
129convergent extension (GO:0060026)2.86382181
130protein retention in ER lumen (GO:0006621)2.84829837
131regulation of nucleobase-containing compound transport (GO:0032239)2.76088079
132mitotic G1 DNA damage checkpoint (GO:0031571)2.74004633
133nucleobase-containing small molecule interconversion (GO:0015949)2.72206878
134apoptotic process involved in morphogenesis (GO:0060561)2.69398633
135DNA synthesis involved in DNA repair (GO:0000731)2.68927532
136metaphase plate congression (GO:0051310)2.68891680
137nuclear envelope reassembly (GO:0031468)2.67973520
138mitotic nuclear envelope reassembly (GO:0007084)2.67973520
139glucocorticoid receptor signaling pathway (GO:0042921)2.67460612
140rRNA transcription (GO:0009303)2.66872912
141establishment of apical/basal cell polarity (GO:0035089)2.65522755
142establishment of chromosome localization (GO:0051303)2.64252621
143ribosome assembly (GO:0042255)2.62832468
144L-serine metabolic process (GO:0006563)2.57393711
145regulation of NFAT protein import into nucleus (GO:0051532)2.54439998
146notochord development (GO:0030903)2.53457662
147protein localization to microtubule (GO:0035372)2.53318276
148G1 DNA damage checkpoint (GO:0044783)2.51500042
149maternal placenta development (GO:0001893)2.50213198
150mitotic cytokinesis (GO:0000281)2.49851252
151cell-substrate junction assembly (GO:0007044)2.49432289
152cellular response to epidermal growth factor stimulus (GO:0071364)2.48143800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.94198548
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.17058311
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.98330113
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.61999785
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51843090
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.23704782
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00836714
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.72821947
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58586666
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.52791368
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48971468
12* MYC_22102868_ChIP-Seq_BL_Human2.40610810
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.38809181
14XRN2_22483619_ChIP-Seq_HELA_Human2.32131916
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03483932
16* E2F1_21310950_ChIP-Seq_MCF-7_Human2.02619856
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02311304
18* ETS1_20019798_ChIP-Seq_JURKAT_Human2.01553393
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98493734
20AR_21909140_ChIP-Seq_LNCAP_Human1.95461564
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.94243101
22VDR_21846776_ChIP-Seq_THP-1_Human1.92176279
23ZNF263_19887448_ChIP-Seq_K562_Human1.88083680
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86909238
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73254093
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72744929
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71319237
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71262777
29CIITA_25753668_ChIP-Seq_RAJI_Human1.70656440
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70364120
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69459877
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64740944
33TTF2_22483619_ChIP-Seq_HELA_Human1.62603694
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59873814
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59250303
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58427706
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56020326
38* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54956510
39LXR_22292898_ChIP-Seq_THP-1_Human1.53333776
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52988360
41FOXP3_21729870_ChIP-Seq_TREG_Human1.52634081
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52200581
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51961213
44GABP_19822575_ChIP-Seq_HepG2_Human1.50734460
45VDR_23849224_ChIP-Seq_CD4+_Human1.50565369
46RACK7_27058665_Chip-Seq_MCF-7_Human1.50485186
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.48223627
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45884180
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.44793114
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44613129
51DCP1A_22483619_ChIP-Seq_HELA_Human1.44484520
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43615517
53CLOCK_20551151_ChIP-Seq_293T_Human1.43374450
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42496584
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41900573
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40636459
57KDM5A_27292631_Chip-Seq_BREAST_Human1.37832277
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37726688
59* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37655533
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37134945
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36670939
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33724439
63* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33705725
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32620583
65TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30876655
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29412570
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28765841
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27796674
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26773170
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25725455
71ATF3_27146783_Chip-Seq_COLON_Human1.24046268
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23612461
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22534445
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20849525
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20567391
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20385294
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20046483
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.20039649
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19135191
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19131115
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14972092
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12175445
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12022466
84KDM2B_26808549_Chip-Seq_DND41_Human1.11940632
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.11921096
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11794902
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10435558
88* TET1_21451524_ChIP-Seq_MESCs_Mouse1.08681623
89* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08269458
90* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08223888
91KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08098570
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08098570
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08098570
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07921673
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07884354
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07015331
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06464663
98TCF7_22412390_ChIP-Seq_EML_Mouse1.06350098
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05882832
100TP53_22127205_ChIP-Seq_IMR90_Human1.04576643
101KDM2B_26808549_Chip-Seq_K562_Human1.02870316
102CHD1_26751641_Chip-Seq_LNCaP_Human1.02609677
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01822726
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00656588
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00352604
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00298523
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99323731
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99100844
109ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97929183
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97686409
111* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97180803
112NCOR1_26117541_ChIP-Seq_K562_Human0.97020712
113TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95863071
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95721019
115UBF1/2_26484160_Chip-Seq_HMECs_Human0.95478927
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94267141
117TFEB_21752829_ChIP-Seq_HELA_Human0.93622625
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92763859
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92708006
120* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92568228
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92467018
122ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91166616
123NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91006411
124UTX_26944678_Chip-Seq_JUKART_Human0.90382378
125HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88939128
126* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88934245
127OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88666382
128* ELK3_25401928_ChIP-Seq_HUVEC_Human0.88523613
129* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84559421
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83212752
131HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.83046975
132ELK1_19687146_ChIP-ChIP_HELA_Human0.82677721
133* FOXP1_21924763_ChIP-Seq_HESCs_Human0.82531463
134FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82373889
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82280650
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82044371
137* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.81740772
138POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.81217710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.21236180
2MP0003111_abnormal_nucleus_morphology4.21042210
3MP0010094_abnormal_chromosome_stability4.04478027
4MP0004957_abnormal_blastocyst_morpholog3.77877132
5MP0003077_abnormal_cell_cycle3.53600148
6MP0008057_abnormal_DNA_replication3.36804724
7MP0010030_abnormal_orbit_morphology3.26820692
8MP0002877_abnormal_melanocyte_morpholog3.01331341
9MP0010352_gastrointestinal_tract_polyps2.63334760
10MP0008932_abnormal_embryonic_tissue2.48590736
11MP0001730_embryonic_growth_arrest2.44288336
12MP0008007_abnormal_cellular_replicative2.40610333
13MP0008058_abnormal_DNA_repair2.32134579
14MP0000350_abnormal_cell_proliferation2.30235066
15MP0005623_abnormal_meninges_morphology2.24234608
16MP0005076_abnormal_cell_differentiation2.21301509
17MP0003123_paternal_imprinting2.20165840
18MP0004185_abnormal_adipocyte_glucose2.05242832
19MP0008438_abnormal_cutaneous_collagen1.95250152
20MP0000537_abnormal_urethra_morphology1.91703020
21MP0010307_abnormal_tumor_latency1.91584918
22MP0003705_abnormal_hypodermis_morpholog1.91374842
23MP0001697_abnormal_embryo_size1.89294297
24MP0002085_abnormal_embryonic_tissue1.89238473
25MP0002084_abnormal_developmental_patter1.88756739
26MP0000490_abnormal_crypts_of1.87181257
27MP0005380_embryogenesis_phenotype1.86005454
28MP0001672_abnormal_embryogenesis/_devel1.86005454
29MP0009278_abnormal_bone_marrow1.84109350
30MP0002396_abnormal_hematopoietic_system1.83904816
31MP0004272_abnormal_basement_membrane1.82536884
32MP0004197_abnormal_fetal_growth/weight/1.74786552
33MP0001293_anophthalmia1.73337807
34MP0009053_abnormal_anal_canal1.72447765
35MP0002080_prenatal_lethality1.69108735
36MP0003283_abnormal_digestive_organ1.68552254
37MP0003984_embryonic_growth_retardation1.68419142
38MP0002088_abnormal_embryonic_growth/wei1.65446031
39MP0002086_abnormal_extraembryonic_tissu1.62099094
40MP0005451_abnormal_body_composition1.59300486
41MP0004858_abnormal_nervous_system1.55621594
42MP0003119_abnormal_digestive_system1.53926833
43MP0000566_synostosis1.44557988
44MP0004808_abnormal_hematopoietic_stem1.43285388
45MP0001348_abnormal_lacrimal_gland1.41347741
46MP0000313_abnormal_cell_death1.36179356
47MP0008877_abnormal_DNA_methylation1.34449654
48MP0003121_genomic_imprinting1.34221072
49MP0003890_abnormal_embryonic-extraembry1.32029969
50MP0002653_abnormal_ependyma_morphology1.27518505
51MP0002019_abnormal_tumor_incidence1.27282381
52MP0003567_abnormal_fetal_cardiomyocyte1.26306073
53MP0004133_heterotaxia1.26198840
54MP0002796_impaired_skin_barrier1.26187842
55MP0000003_abnormal_adipose_tissue1.26044039
56MP0003786_premature_aging1.25151392
57MP0003091_abnormal_cell_migration1.23915263
58MP0001346_abnormal_lacrimal_gland1.23024718
59MP0000762_abnormal_tongue_morphology1.22755934
60MP0003453_abnormal_keratinocyte_physiol1.21920688
61MP0002060_abnormal_skin_morphology1.20620772
62MP0000428_abnormal_craniofacial_morphol1.20612459
63MP0004233_abnormal_muscle_weight1.19944694
64MP0002249_abnormal_larynx_morphology1.19732889
65MP0000049_abnormal_middle_ear1.19256710
66MP0000678_abnormal_parathyroid_gland1.14552517
67MP0003942_abnormal_urinary_system1.14075243
68MP0005397_hematopoietic_system_phenotyp1.14051661
69MP0001545_abnormal_hematopoietic_system1.14051661
70MP0002111_abnormal_tail_morphology1.11833356
71MP0002092_abnormal_eye_morphology1.10717271
72MP0003115_abnormal_respiratory_system1.10000430
73MP0005409_darkened_coat_color1.08879610
74MP0002210_abnormal_sex_determination1.05620632
75MP0000534_abnormal_ureter_morphology1.05151303
76MP0001929_abnormal_gametogenesis1.02077832
77MP0000703_abnormal_thymus_morphology1.01904642
78MP0005621_abnormal_cell_physiology1.00876507
79MP0002089_abnormal_postnatal_growth/wei1.00616891
80MP0001849_ear_inflammation1.00529437
81MP0001145_abnormal_male_reproductive0.99976739
82MP0006054_spinal_hemorrhage0.99749750
83MP0001661_extended_life_span0.99234948
84MP0002282_abnormal_trachea_morphology0.98470183
85MP0000733_abnormal_muscle_development0.96941604
86MP0003941_abnormal_skin_development0.96041062
87MP0009672_abnormal_birth_weight0.95718582
88MP0000579_abnormal_nail_morphology0.95657574
89MP0003937_abnormal_limbs/digits/tail_de0.93168489
90MP0000477_abnormal_intestine_morphology0.90669619
91MP0003935_abnormal_craniofacial_develop0.89526789
92MP0001299_abnormal_eye_distance/0.89350247
93MP0003566_abnormal_cell_adhesion0.88819834
94MP0003315_abnormal_perineum_morphology0.87968015
95MP0002932_abnormal_joint_morphology0.86384779
96* MP0003861_abnormal_nervous_system0.86338279
97MP0005666_abnormal_adipose_tissue0.84151651
98MP0009703_decreased_birth_body0.83776101
99MP0005023_abnormal_wound_healing0.83192176
100MP0005375_adipose_tissue_phenotype0.82547848
101MP0002697_abnormal_eye_size0.82303504
102MP0000467_abnormal_esophagus_morphology0.82091289
103MP0001286_abnormal_eye_development0.81758008
104MP0001216_abnormal_epidermal_layer0.81209973
105MP0000432_abnormal_head_morphology0.80862444
106MP0003385_abnormal_body_wall0.78823396
107MP0008789_abnormal_olfactory_epithelium0.77329668
108MP0010630_abnormal_cardiac_muscle0.76246686
109MP0000653_abnormal_sex_gland0.75269563
110MP0003755_abnormal_palate_morphology0.74508080
111MP0002114_abnormal_axial_skeleton0.74023861
112MP0004264_abnormal_extraembryonic_tissu0.73914931
113MP0000858_altered_metastatic_potential0.73779404
114MP0010234_abnormal_vibrissa_follicle0.72715000
115MP0002751_abnormal_autonomic_nervous0.72701510
116MP0000751_myopathy0.72616180
117MP0000358_abnormal_cell_content/0.72350700
118MP0005257_abnormal_intraocular_pressure0.71772042
119MP0002398_abnormal_bone_marrow0.71707880
120MP0002722_abnormal_immune_system0.71549694
121MP0000759_abnormal_skeletal_muscle0.71293219
122MP0008770_decreased_survivor_rate0.71215273
123MP0003698_abnormal_male_reproductive0.70985866
124MP0005410_abnormal_fertilization0.70889470
125MP0002925_abnormal_cardiovascular_devel0.69861644
126MP0009333_abnormal_splenocyte_physiolog0.69491666
127MP0005384_cellular_phenotype0.68332095
128MP0003763_abnormal_thymus_physiology0.68032305
129MP0001915_intracranial_hemorrhage0.67234419
130MP0005501_abnormal_skin_physiology0.66117846
131MP0002116_abnormal_craniofacial_bone0.65787819

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.15336247
2Ependymoma (HP:0002888)3.78423539
3Premature rupture of membranes (HP:0001788)3.64915088
4Selective tooth agenesis (HP:0001592)3.33959297
5Ulnar bowing (HP:0003031)3.31173228
6Colon cancer (HP:0003003)3.28924446
7Medulloblastoma (HP:0002885)3.20722940
8Increased nuchal translucency (HP:0010880)3.15587868
9Insomnia (HP:0100785)3.04238631
10Protrusio acetabuli (HP:0003179)2.89406136
11Abnormality of cells of the erythroid lineage (HP:0012130)2.88634313
12Absent radius (HP:0003974)2.81610843
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.79658358
14Short 4th metacarpal (HP:0010044)2.79658358
15Rhabdomyosarcoma (HP:0002859)2.72429018
16Abnormal number of erythroid precursors (HP:0012131)2.68577235
17Absent thumb (HP:0009777)2.64468836
18Patellar aplasia (HP:0006443)2.63955001
19Aplasia involving forearm bones (HP:0009822)2.63740751
20Absent forearm bone (HP:0003953)2.63740751
21Abnormal number of incisors (HP:0011064)2.63510857
22Chromsome breakage (HP:0040012)2.62460724
23Breast hypoplasia (HP:0003187)2.59094177
24Neoplasm of striated muscle (HP:0009728)2.57756165
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.57340687
26Aplasia/Hypoplasia of the patella (HP:0006498)2.55902796
27Trismus (HP:0000211)2.53830041
28Astrocytoma (HP:0009592)2.53717034
29Abnormality of the astrocytes (HP:0100707)2.53717034
30Shallow orbits (HP:0000586)2.53545403
31Hyperacusis (HP:0010780)2.49836597
32Basal cell carcinoma (HP:0002671)2.48634339
33Proximal placement of thumb (HP:0009623)2.47969458
34Renal duplication (HP:0000075)2.47784894
35Atresia of the external auditory canal (HP:0000413)2.43849987
36Abnormality of the ileum (HP:0001549)2.41315404
37Distal lower limb amyotrophy (HP:0008944)2.38964917
38Abnormality of the anterior horn cell (HP:0006802)2.37979450
39Degeneration of anterior horn cells (HP:0002398)2.37979450
40Meckel diverticulum (HP:0002245)2.37544508
41Birth length less than 3rd percentile (HP:0003561)2.37233878
42Achilles tendon contracture (HP:0001771)2.37170388
43Deviation of the thumb (HP:0009603)2.37122807
44Missing ribs (HP:0000921)2.37078993
45Impulsivity (HP:0100710)2.35595942
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.35517141
47Long palpebral fissure (HP:0000637)2.35416938
48Abnormality of the distal phalanx of the thumb (HP:0009617)2.33975540
49Disproportionate tall stature (HP:0001519)2.33673118
50Broad face (HP:0000283)2.33498436
51Abnormality of chromosome stability (HP:0003220)2.32483441
52Agnosia (HP:0010524)2.31505914
53Asymmetry of the thorax (HP:0001555)2.27792368
54Broad distal phalanx of finger (HP:0009836)2.26126945
55Neoplasm of the oral cavity (HP:0100649)2.25046715
56Oral leukoplakia (HP:0002745)2.21893034
57Abnormality of the preputium (HP:0100587)2.21757245
58Pallor (HP:0000980)2.21201739
59Neoplasm of the pancreas (HP:0002894)2.20552896
60Gastrointestinal carcinoma (HP:0002672)2.19430721
61Malignant gastrointestinal tract tumors (HP:0006749)2.19430721
62Glioma (HP:0009733)2.17603095
63Heterotopia (HP:0002282)2.15906204
64Ankle contracture (HP:0006466)2.14639650
65Progressive muscle weakness (HP:0003323)2.14590919
6611 pairs of ribs (HP:0000878)2.14448484
67Ankyloglossia (HP:0010296)2.11536764
68Myelodysplasia (HP:0002863)2.09180657
69Small intestinal stenosis (HP:0012848)2.08118018
70Duodenal stenosis (HP:0100867)2.08118018
71Abnormality of abdominal situs (HP:0011620)2.07022513
72Abdominal situs inversus (HP:0003363)2.07022513
73Spinal rigidity (HP:0003306)2.05388403
74Short nail (HP:0001799)2.04834340
75Fragile skin (HP:0001030)2.04185144
76Abnormality of oral frenula (HP:0000190)2.04006751
77Tracheoesophageal fistula (HP:0002575)2.03871590
78Abnormality of the phalanges of the hallux (HP:0010057)2.03268741
79Aplasia/hypoplasia of the humerus (HP:0006507)2.01902722
80High pitched voice (HP:0001620)2.01780074
81Renovascular hypertension (HP:0100817)2.01435704
82Abnormality of the Achilles tendon (HP:0005109)2.01167358
83Macrocytic anemia (HP:0001972)2.00380454
84Abnormality of the carotid arteries (HP:0005344)1.99077150
85Turricephaly (HP:0000262)1.98633846
86Arnold-Chiari malformation (HP:0002308)1.98432662
87Increased connective tissue (HP:0009025)1.96611838
88Bladder diverticulum (HP:0000015)1.96421084
89Patellar dislocation (HP:0002999)1.94896933
90Neonatal short-limb short stature (HP:0008921)1.93553231
91Abnormality of the 4th metacarpal (HP:0010012)1.93460897
92Adenoma sebaceum (HP:0009720)1.93149481
93Angiofibromas (HP:0010615)1.93149481
94Lower limb amyotrophy (HP:0007210)1.92802686
95High anterior hairline (HP:0009890)1.92548787
96Pointed chin (HP:0000307)1.91737102
97Triphalangeal thumb (HP:0001199)1.91535865
98Rib fusion (HP:0000902)1.90878668
99Natal tooth (HP:0000695)1.90653902
100Ectopic kidney (HP:0000086)1.90043583
101Cafe-au-lait spot (HP:0000957)1.89552796
102Abnormality of the umbilical cord (HP:0010881)1.88740492
103Spastic diplegia (HP:0001264)1.88668421
104Abnormality of the labia minora (HP:0012880)1.88375973
105Abnormality of the distal phalanges of the toes (HP:0010182)1.87162615
106Thrombocytosis (HP:0001894)1.86299171
107Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.86271961
108Short thumb (HP:0009778)1.86055521
109Aplastic anemia (HP:0001915)1.85219935
110Urethral obstruction (HP:0000796)1.84640132
111Short humerus (HP:0005792)1.83554322
112Aplasia/Hypoplasia of the sternum (HP:0006714)1.83048127
113Biconcave vertebral bodies (HP:0004586)1.82595317
114Short phalanx of the thumb (HP:0009660)1.82351010
115Skin tags (HP:0010609)1.82338115
116Coronal craniosynostosis (HP:0004440)1.82010837
117Abnormality of the duodenum (HP:0002246)1.81538562
118Dysmetric saccades (HP:0000641)1.81459259
119Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80506058
120Horseshoe kidney (HP:0000085)1.80434581
121Back pain (HP:0003418)1.80235342
122Genu recurvatum (HP:0002816)1.79934847
123Hypoplasia of the radius (HP:0002984)1.79352771
124Trigonocephaly (HP:0000243)1.79270795
125Skull defect (HP:0001362)1.79099126
126Flat acetabular roof (HP:0003180)1.78948230
127Facial hemangioma (HP:0000329)1.78379818
128Vertebral compression fractures (HP:0002953)1.78040545
129Glossoptosis (HP:0000162)1.77714199
130Microretrognathia (HP:0000308)1.77356715
131Sloping forehead (HP:0000340)1.76831121
132Vertebral arch anomaly (HP:0008438)1.76506007
133Syringomyelia (HP:0003396)1.76029745
134Spinal cord lesions (HP:0100561)1.76029745
135Bowing of the arm (HP:0006488)1.75728179
136Bowed forearm bones (HP:0003956)1.75728179
137Abnormality of the calcaneus (HP:0008364)1.74523412
138Osteolytic defects of the phalanges of the hand (HP:0009771)1.73946601
139Osteolytic defects of the hand bones (HP:0009699)1.73946601
140Intestinal polyp (HP:0005266)1.73720881
141Duplication of thumb phalanx (HP:0009942)1.73576947
142Thin ribs (HP:0000883)1.73479549
143Preauricular skin tag (HP:0000384)1.72963985
144Partial duplication of the phalanx of hand (HP:0009999)1.72051220
145Deep palmar crease (HP:0006191)1.71753857
146Midface retrusion (HP:0011800)1.71744786
147Flat cornea (HP:0007720)1.71513467
148Elfin facies (HP:0004428)1.71217986
149Elbow flexion contracture (HP:0002987)1.70869649
150Cortical dysplasia (HP:0002539)1.70666901
151Duplicated collecting system (HP:0000081)1.70303461
152Rough bone trabeculation (HP:0100670)1.69855234
153Slender long bone (HP:0003100)1.69687475
154Long eyelashes (HP:0000527)1.69566138
155Upper limb amyotrophy (HP:0009129)1.69439138
156Distal upper limb amyotrophy (HP:0007149)1.69439138
157Prominent nose (HP:0000448)1.69336074
158Multiple enchondromatosis (HP:0005701)1.69037106
159Termporal pattern (HP:0011008)1.68445194
160Insidious onset (HP:0003587)1.68445194
161Overriding aorta (HP:0002623)1.67620741
162Atrophy/Degeneration involving motor neurons (HP:0007373)1.67526172
163Overlapping toe (HP:0001845)1.67461366
164Centrally nucleated skeletal muscle fibers (HP:0003687)1.67089889
165Advanced eruption of teeth (HP:0006288)1.65975945
166Difficulty climbing stairs (HP:0003551)1.65005499
167Bowel diverticulosis (HP:0005222)1.64963408
168Pseudobulbar signs (HP:0002200)1.64279933
169Abnormality of dentin (HP:0010299)1.63289135
170Atrophic scars (HP:0001075)1.62890596
171Dislocated radial head (HP:0003083)1.61358287
172Unilateral renal agenesis (HP:0000122)1.60067259
173Flared metaphyses (HP:0003015)1.59178269
174Orthostatic hypotension (HP:0001278)1.58125014
175Mitral regurgitation (HP:0001653)1.57561519
176Wormian bones (HP:0002645)1.57341855
177Progressive external ophthalmoplegia (HP:0000590)1.57162603
178Premature skin wrinkling (HP:0100678)1.57149143
179Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55962487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.04793670
2SMG14.07542771
3CDC73.79055120
4NEK23.54475791
5EEF2K3.47387427
6MAP3K103.22738576
7WEE12.95820085
8TLK12.73114704
9PKN22.46726195
10CDK122.44198555
11IRAK32.31265712
12TTK2.19533717
13RPS6KB22.15552520
14TESK21.95431562
15MST1R1.88613354
16PASK1.87864443
17TRIB31.87784808
18NEK11.87507991
19LATS21.81861479
20CDK71.74486804
21PLK11.72432427
22PAK41.72227246
23ICK1.70946508
24SIK11.70480213
25PRPF4B1.70295438
26CDK41.61410975
27ATR1.60973178
28SCYL21.52823703
29SRPK11.52802603
30TSSK61.52522882
31DYRK31.50272096
32AURKB1.49768729
33TESK11.48146869
34STK101.40530271
35VRK21.34558709
36MAP3K81.33265958
37EIF2AK11.32343938
38CHEK21.30626672
39PTK21.23078404
40CHEK11.22944651
41EPHA21.20823129
42NME21.19838738
43MET1.19000232
44MKNK11.17376414
45PBK1.14822549
46FGFR41.14361896
47AURKA1.10142335
48CDK61.08101204
49TGFBR11.07162177
50TAF11.06718782
51ALK1.04262732
52FLT31.03472810
53LRRK21.01607860
54BRSK20.97633992
55RPS6KA40.97508901
56MTOR0.96186068
57BRAF0.95836221
58GRK60.93809095
59* CDK20.93137476
60LATS10.92337873
61NTRK10.91877967
62MAPKAPK30.90584714
63BRSK10.90106094
64ERBB40.89074676
65MKNK20.85026191
66CDK80.84899600
67PIM10.84829006
68VRK10.84471871
69ATM0.83797015
70ARAF0.82304156
71MAP3K110.81509907
72STK40.81314066
73BRD40.79002969
74MAP3K90.78962331
75TAOK20.75579138
76UHMK10.74797519
77DYRK1B0.74189449
78PLK40.72140056
79PRKD30.71033732
80MELK0.70717891
81PTK60.68021339
82MAP4K10.67997280
83PAK10.67302984
84ACVR1B0.67076430
85AKT20.65788662
86KSR20.64654567
87PLK30.64625944
88PIM20.63576568
89FGFR10.63099357
90CLK10.62169738
91CDK90.62123977
92* CDK10.59800241
93CAMK1D0.59247865
94PAK20.58925883
95CSNK2A20.58411037
96PDGFRA0.56900793
97MOS0.54503128
98LMTK20.54317144
99KDR0.53893142
100ILK0.52893261
101CAMK1G0.51618570
102TTN0.50640574
103ERN10.48802164
104IRAK20.48210196
105BTK0.46796662
106BMX0.46378677
107RPS6KA20.43863171
108CSNK2A10.43854682
109PRKCI0.42888573
110PRKDC0.42430739
111CDK140.41235959
112MAP3K130.40500141
113EPHB20.40486976
114DMPK0.39149930
115CSNK1E0.38994043
116DAPK10.38134783
117MAP2K20.37819353
118RPS6KA10.37035475
119CDK11A0.35015639
120EIF2AK30.34508011
121MAPK110.34265178
122STK160.33125337
123CDK150.32567313
124MAP2K30.31690357
125DDR20.29832580
126MAPK140.29758823
127TYRO30.29556596
128RPS6KL10.27910234
129RPS6KC10.27910234
130CDK180.27498790
131STK30.26094474
132MAPK90.26026828
133RIPK10.25880399

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.32892926
2Mismatch repair_Homo sapiens_hsa034304.25183962
3Spliceosome_Homo sapiens_hsa030403.51053808
4Base excision repair_Homo sapiens_hsa034103.50740059
5Ribosome_Homo sapiens_hsa030103.12870986
6RNA transport_Homo sapiens_hsa030133.04012376
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.95590067
8One carbon pool by folate_Homo sapiens_hsa006702.92091192
9Cell cycle_Homo sapiens_hsa041102.79089820
10Homologous recombination_Homo sapiens_hsa034402.75600584
11Nucleotide excision repair_Homo sapiens_hsa034202.52228238
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47354164
13Fanconi anemia pathway_Homo sapiens_hsa034602.24698425
14mRNA surveillance pathway_Homo sapiens_hsa030152.18517056
15RNA polymerase_Homo sapiens_hsa030201.81997815
16Pyrimidine metabolism_Homo sapiens_hsa002401.80283799
17Systemic lupus erythematosus_Homo sapiens_hsa053221.66007568
18RNA degradation_Homo sapiens_hsa030181.52748468
19Non-homologous end-joining_Homo sapiens_hsa034501.51656002
20p53 signaling pathway_Homo sapiens_hsa041151.44850362
21Proteasome_Homo sapiens_hsa030501.41943300
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35469416
23Basal cell carcinoma_Homo sapiens_hsa052171.30063227
24Notch signaling pathway_Homo sapiens_hsa043301.24756938
25Viral carcinogenesis_Homo sapiens_hsa052031.22882539
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22024421
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21490650
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17914504
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15471720
30Oocyte meiosis_Homo sapiens_hsa041141.15307911
31Basal transcription factors_Homo sapiens_hsa030221.13117251
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11551162
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.09561584
34Vitamin B6 metabolism_Homo sapiens_hsa007501.08885796
35MicroRNAs in cancer_Homo sapiens_hsa052061.07511062
36HTLV-I infection_Homo sapiens_hsa051661.04820500
37Bladder cancer_Homo sapiens_hsa052191.04319137
38Sulfur relay system_Homo sapiens_hsa041221.01231370
39Chronic myeloid leukemia_Homo sapiens_hsa052200.99989440
40Epstein-Barr virus infection_Homo sapiens_hsa051690.99454575
41Hedgehog signaling pathway_Homo sapiens_hsa043400.99436228
42Selenocompound metabolism_Homo sapiens_hsa004500.98276592
43Thyroid cancer_Homo sapiens_hsa052160.94461157
44Biosynthesis of amino acids_Homo sapiens_hsa012300.93667579
45Central carbon metabolism in cancer_Homo sapiens_hsa052300.93247258
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89543726
47Hippo signaling pathway_Homo sapiens_hsa043900.89537874
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89381246
49ECM-receptor interaction_Homo sapiens_hsa045120.85933445
50Prion diseases_Homo sapiens_hsa050200.85496459
51Small cell lung cancer_Homo sapiens_hsa052220.85079157
52Renal cell carcinoma_Homo sapiens_hsa052110.83900945
53Herpes simplex infection_Homo sapiens_hsa051680.82138795
54ErbB signaling pathway_Homo sapiens_hsa040120.82102320
55Pentose phosphate pathway_Homo sapiens_hsa000300.81756825
56Colorectal cancer_Homo sapiens_hsa052100.81671084
57Alcoholism_Homo sapiens_hsa050340.81523226
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79789466
59Antigen processing and presentation_Homo sapiens_hsa046120.79530674
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77582053
61Purine metabolism_Homo sapiens_hsa002300.77413295
62Melanoma_Homo sapiens_hsa052180.77107934
63Insulin signaling pathway_Homo sapiens_hsa049100.72865404
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71498488
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70308961
66Lysine degradation_Homo sapiens_hsa003100.67307424
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67169564
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63688681
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63682493
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61583949
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60450604
72N-Glycan biosynthesis_Homo sapiens_hsa005100.59561442
73Acute myeloid leukemia_Homo sapiens_hsa052210.59270323
74mTOR signaling pathway_Homo sapiens_hsa041500.58995315
75TGF-beta signaling pathway_Homo sapiens_hsa043500.58699206
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.58023256
77Melanogenesis_Homo sapiens_hsa049160.56348458
78Fructose and mannose metabolism_Homo sapiens_hsa000510.55866592
79Shigellosis_Homo sapiens_hsa051310.54251982
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54049546
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53201694
82Adherens junction_Homo sapiens_hsa045200.52842159
83Legionellosis_Homo sapiens_hsa051340.51761896
84Pathways in cancer_Homo sapiens_hsa052000.48368147
85* Apoptosis_Homo sapiens_hsa042100.47506599
86Non-small cell lung cancer_Homo sapiens_hsa052230.46573857
87Wnt signaling pathway_Homo sapiens_hsa043100.46346879
88Proteoglycans in cancer_Homo sapiens_hsa052050.46059053
89Hepatitis B_Homo sapiens_hsa051610.45806732
90Estrogen signaling pathway_Homo sapiens_hsa049150.45563425
91Gap junction_Homo sapiens_hsa045400.42372875
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.41481995
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40864238
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39035980
95HIF-1 signaling pathway_Homo sapiens_hsa040660.38476565
96Endometrial cancer_Homo sapiens_hsa052130.38336287
97Carbon metabolism_Homo sapiens_hsa012000.37901296
98Viral myocarditis_Homo sapiens_hsa054160.37007214
99Folate biosynthesis_Homo sapiens_hsa007900.36286846
100Galactose metabolism_Homo sapiens_hsa000520.35970116
101Primary immunodeficiency_Homo sapiens_hsa053400.35342082
102Tight junction_Homo sapiens_hsa045300.31670066
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30559876
104Pancreatic cancer_Homo sapiens_hsa052120.28795824
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.28395769
106B cell receptor signaling pathway_Homo sapiens_hsa046620.28337882
107VEGF signaling pathway_Homo sapiens_hsa043700.28235288
108Prostate cancer_Homo sapiens_hsa052150.26724411
109Glutathione metabolism_Homo sapiens_hsa004800.26711506
110Renin-angiotensin system_Homo sapiens_hsa046140.24404995
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.23928806
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.22167729
113AMPK signaling pathway_Homo sapiens_hsa041520.18068356
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17016091
115Focal adhesion_Homo sapiens_hsa045100.16047190
116Glioma_Homo sapiens_hsa052140.16038713
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15548234
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15310029
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14875697

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