LMNTD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.81837426
2cell wall macromolecule metabolic process (GO:0044036)9.65790693
3cell wall macromolecule catabolic process (GO:0016998)9.65790693
4acrosome assembly (GO:0001675)9.54300745
5binding of sperm to zona pellucida (GO:0007339)9.19864493
6cell-cell recognition (GO:0009988)9.06302726
7multicellular organism reproduction (GO:0032504)9.01519965
8spermatid development (GO:0007286)8.53514486
9epithelial cilium movement (GO:0003351)8.31098600
10cilium or flagellum-dependent cell motility (GO:0001539)8.27257128
11axonemal dynein complex assembly (GO:0070286)8.09058690
12plasma membrane fusion (GO:0045026)8.02197130
13motile cilium assembly (GO:0044458)7.82712261
14regulation of cilium movement (GO:0003352)7.79510190
15reproduction (GO:0000003)7.73289933
16male meiosis (GO:0007140)6.97453437
17synaptonemal complex organization (GO:0070193)6.82482087
18synaptonemal complex assembly (GO:0007130)6.80888712
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.80238050
20piRNA metabolic process (GO:0034587)6.79599215
21cilium movement (GO:0003341)6.70979523
22sperm capacitation (GO:0048240)6.23443583
23single fertilization (GO:0007338)6.06043077
24phosphatidylethanolamine biosynthetic process (GO:0006646)5.94431962
25spermatogenesis (GO:0007283)5.80264722
26male gamete generation (GO:0048232)5.78584073
27organic cation transport (GO:0015695)5.73509989
28negative regulation of inclusion body assembly (GO:0090084)5.72631430
29fertilization (GO:0009566)5.44420005
30phosphatidylethanolamine metabolic process (GO:0046337)5.37538293
31microtubule depolymerization (GO:0007019)5.34428884
32gamete generation (GO:0007276)5.30983427
33chromosome condensation (GO:0030261)5.26765363
34germ cell development (GO:0007281)4.96958908
35DNA packaging (GO:0006323)4.95898521
36regulation of microtubule-based movement (GO:0060632)4.89098604
37response to pheromone (GO:0019236)4.84525925
38male meiosis I (GO:0007141)4.84028450
39regulation of Rab GTPase activity (GO:0032313)4.83749166
40positive regulation of Rab GTPase activity (GO:0032851)4.83749166
41cellular process involved in reproduction in multicellular organism (GO:0022412)4.81324867
42regulation of inclusion body assembly (GO:0090083)4.73977449
43chromosome organization involved in meiosis (GO:0070192)4.72082163
44regulation of ARF GTPase activity (GO:0032312)4.69077308
45histone H3-K9 demethylation (GO:0033169)4.67504592
46glycerol ether metabolic process (GO:0006662)4.64435458
47protein targeting to Golgi (GO:0000042)4.60548938
48retrograde transport, vesicle recycling within Golgi (GO:0000301)4.46580465
49DNA methylation involved in gamete generation (GO:0043046)4.39861737
50meiotic nuclear division (GO:0007126)4.38260234
51establishment of protein localization to Golgi (GO:0072600)4.34808481
52ether metabolic process (GO:0018904)4.24788703
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.20127620
54multicellular organismal reproductive process (GO:0048609)4.19527044
55meiosis I (GO:0007127)4.08927861
56seminiferous tubule development (GO:0072520)4.04123236
57calcium ion-dependent exocytosis (GO:0017156)3.92987704
58ventricular system development (GO:0021591)3.92740612
59response to acidic pH (GO:0010447)3.91526167
60chaperone-mediated protein complex assembly (GO:0051131)3.89025941
61single strand break repair (GO:0000012)3.85731705
62regulation of T-helper 2 cell differentiation (GO:0045628)3.83406994
63spermatid nucleus differentiation (GO:0007289)3.83242985
64genitalia morphogenesis (GO:0035112)3.82441994
65microtubule severing (GO:0051013)3.81816606
66left/right pattern formation (GO:0060972)3.81258025
67cell-cell junction maintenance (GO:0045217)3.79192099
68cell recognition (GO:0008037)3.78013705
69rRNA methylation (GO:0031167)3.75405193
70nucleosome disassembly (GO:0006337)3.74967928
71protein-DNA complex disassembly (GO:0032986)3.74967928
72cellular response to pH (GO:0071467)3.68262846
73microtubule polymerization or depolymerization (GO:0031109)3.68206240
74RNA destabilization (GO:0050779)3.56395223
75histone H4 deacetylation (GO:0070933)3.56027553
76cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.52311635
77interferon-gamma secretion (GO:0072643)3.47111103
78regulation of histone H3-K27 methylation (GO:0061085)3.46964803
79positive regulation of histone deacetylation (GO:0031065)3.46839695
80protein localization to Golgi apparatus (GO:0034067)3.44228486
81regulation of interleukin-13 production (GO:0032656)3.43991853
82multicellular organismal development (GO:0007275)3.40735655
83membrane protein intracellular domain proteolysis (GO:0031293)3.38926396
84regulation of transcription involved in cell fate commitment (GO:0060850)3.37615152
85insulin-like growth factor receptor signaling pathway (GO:0048009)3.30758608
86RNA localization (GO:0006403)3.29784409
87centriole assembly (GO:0098534)3.25843002
88sexual reproduction (GO:0019953)3.24484820
89mitotic sister chromatid cohesion (GO:0007064)3.23401987
90monoubiquitinated protein deubiquitination (GO:0035520)3.22312719
91regulation of somitogenesis (GO:0014807)3.20750814
92meiotic cell cycle (GO:0051321)3.18648258
93gene silencing by RNA (GO:0031047)3.15466341
94histone H3 deacetylation (GO:0070932)3.13872833
95cellular ketone body metabolic process (GO:0046950)3.13472269
96cranial nerve morphogenesis (GO:0021602)3.12892474
97lactate metabolic process (GO:0006089)3.10510582
98nucleus organization (GO:0006997)3.08049598
99cerebral cortex neuron differentiation (GO:0021895)3.07580894
100negative regulation of Rho protein signal transduction (GO:0035024)3.03176395
101meiotic cell cycle process (GO:1903046)3.00116993
102regulation of chromatin binding (GO:0035561)2.97086290
103face development (GO:0060324)2.96060517
104heterochromatin organization (GO:0070828)2.95805199
105tooth mineralization (GO:0034505)2.95604973
106regulation of cilium assembly (GO:1902017)2.94731475
107gene silencing (GO:0016458)2.90871642
108protein polyglutamylation (GO:0018095)2.90809623
109negative regulation of granulocyte differentiation (GO:0030853)2.90068628
110protein refolding (GO:0042026)2.89841796
111establishment of apical/basal cell polarity (GO:0035089)2.85692548
112cell junction maintenance (GO:0034331)2.84439944
113nuclear pore complex assembly (GO:0051292)2.83375091
114chromatin silencing (GO:0006342)2.83002285
115endothelial cell chemotaxis (GO:0035767)2.82961774
116receptor recycling (GO:0001881)2.82802634
117sequestering of actin monomers (GO:0042989)2.81394800
118regulation of histone H3-K9 methylation (GO:0051570)2.79524572
119histone lysine demethylation (GO:0070076)2.79491527
120planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78746736
121peptide catabolic process (GO:0043171)2.77612224
122positive regulation of protein kinase C signaling (GO:0090037)2.77465633
123coenzyme catabolic process (GO:0009109)2.72482519
124rRNA modification (GO:0000154)2.71475690
125glycolytic process (GO:0006096)2.71232005
126amino-acid betaine transport (GO:0015838)2.70029737
127carnitine transport (GO:0015879)2.70029737
128mannose metabolic process (GO:0006013)2.69789107
129regulation of ruffle assembly (GO:1900027)2.69471022
130intraciliary transport (GO:0042073)2.69160395
131regulation of spindle checkpoint (GO:0090231)2.68986741
132oocyte development (GO:0048599)2.68360420
133negative regulation of histone methylation (GO:0031061)2.68076505
134intracellular estrogen receptor signaling pathway (GO:0030520)2.66836523
135semaphorin-plexin signaling pathway (GO:0071526)2.65696233
136histone demethylation (GO:0016577)2.64390186
137ketone body metabolic process (GO:1902224)2.64034741
138neuronal ion channel clustering (GO:0045161)2.63114539
139rRNA catabolic process (GO:0016075)2.62737226
140centriole replication (GO:0007099)2.62195435
141synapsis (GO:0007129)2.56666239
142carnitine transmembrane transport (GO:1902603)2.53170790
143protein localization to cilium (GO:0061512)2.52737938
144protein localization to chromosome, centromeric region (GO:0071459)2.52264065
145nuclear pore organization (GO:0006999)2.47499042
146cilium organization (GO:0044782)2.43607327
147DNA conformation change (GO:0071103)2.42580326
148polyol catabolic process (GO:0046174)2.39332504
149positive regulation of glycolytic process (GO:0045821)2.36385090
150cell redox homeostasis (GO:0045454)2.35179962
151Golgi transport vesicle coating (GO:0048200)2.34661799
152COPI coating of Golgi vesicle (GO:0048205)2.34661799
153DNA methylation (GO:0006306)2.34528053
154DNA alkylation (GO:0006305)2.34528053
155polyamine biosynthetic process (GO:0006596)2.33019436
156negative regulation of gene expression, epigenetic (GO:0045814)2.32811575
157sperm motility (GO:0030317)11.7355818
158fusion of sperm to egg plasma membrane (GO:0007342)10.9406932
159sperm-egg recognition (GO:0035036)10.0691812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1LXR_22292898_ChIP-Seq_THP-1_Human3.28803714
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.11261888
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.10418924
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.02419335
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.89224580
6CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.88849589
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41008255
8SMC4_20622854_ChIP-Seq_HELA_Human2.33419949
9CTCF_27219007_Chip-Seq_Bcells_Human2.32932714
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32621497
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20532228
12DROSHA_22980978_ChIP-Seq_HELA_Human2.09061663
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.08867287
14KDM2B_26808549_Chip-Seq_DND41_Human2.06023966
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02016156
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.1096247
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98407337
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96975819
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94304172
20KDM2B_26808549_Chip-Seq_K562_Human1.93767602
21SA1_27219007_Chip-Seq_ERYTHROID_Human1.89583718
22RACK7_27058665_Chip-Seq_MCF-7_Human1.87870312
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.87719740
24FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87061370
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85765560
26EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.85112621
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.76041977
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73960338
29SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.72213351
30VDR_22108803_ChIP-Seq_LS180_Human1.71491790
31EZH2_22144423_ChIP-Seq_EOC_Human1.70150746
32VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.66181840
33E2F7_22180533_ChIP-Seq_HELA_Human1.64427978
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61021749
35SOX2_22085726_ChIP-Seq_NPCs_Mouse1.59392453
36VDR_21846776_ChIP-Seq_THP-1_Human1.57504984
37GATA3_21867929_ChIP-Seq_CD8_Mouse1.57288736
38FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.53414643
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52485245
40MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.49857901
41CREB1_26743006_Chip-Seq_LNCaP_Human1.49037670
42STAT1_17558387_ChIP-Seq_HELA_Human1.48807389
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.47970577
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47364389
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47291324
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.46705244
47EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.46429864
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.45973632
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43657994
50ERA_21632823_ChIP-Seq_H3396_Human1.41024914
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40740203
52SA1_27219007_Chip-Seq_Bcells_Human1.40477770
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.39153470
54SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38972617
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.38355848
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38345197
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38224381
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38162569
59WDR5_24793694_ChIP-Seq_LNCAP_Human1.37540408
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37520828
61ZNF274_21170338_ChIP-Seq_K562_Hela1.37361764
62YY1_22570637_ChIP-Seq_MALME-3M_Human1.35103242
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34427439
64RARA_24833708_ChIP-Seq_LIVER_Mouse1.33192609
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.32713954
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.31760759
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.30300815
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30138690
69P53_21459846_ChIP-Seq_SAOS-2_Human1.29581133
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28999926
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28888422
72CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28150143
73P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.27757241
74OCT4_19829295_ChIP-Seq_ESCs_Human1.27691617
75MAF_26560356_Chip-Seq_TH2_Human1.27655989
76PHF8_20622854_ChIP-Seq_HELA_Human1.27479684
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26911413
78SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26866757
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26266663
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25616309
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.25386701
82TP53_22127205_ChIP-Seq_IMR90_Human1.25218743
83CTCF_21964334_Chip-Seq_Bcells_Human1.23412656
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23233010
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23214972
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.22287192
87DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22014020
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21550715
89LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.21500999
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21238835
91GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.21069476
92KLF5_25053715_ChIP-Seq_YYC3_Human1.19496879
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19410520
94RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17348824
95GATA1_19941826_ChIP-Seq_K562_Human1.16439156
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16218392
97BCOR_27268052_Chip-Seq_Bcells_Human1.16136643
98NCOR1_26117541_ChIP-Seq_K562_Human1.15576919
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14557471
100TET1_21490601_ChIP-Seq_MESCs_Mouse1.13870395
101SPI1_26923725_Chip-Seq_HPCs_Mouse1.13819404
102MYB_26560356_Chip-Seq_TH2_Human1.13672699
103TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12229797
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11942136
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10644276
106KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10202524
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09264949
108TP63_17297297_ChIP-ChIP_HaCaT_Human1.08980320
109CTCF_20526341_ChIP-Seq_ESCs_Human1.08188220
110GATA3_21867929_ChIP-Seq_TH1_Mouse1.07994106
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07390028
112CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06739768
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06659050
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05573576
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05420583
116CTCF_26484167_Chip-Seq_Bcells_Mouse1.04312995
117RARB_24833708_ChIP-Seq_LIVER_Mouse1.04230434
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04147536
119RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03705887
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03653247
121VDR_24763502_ChIP-Seq_THP-1_Human1.03244468
122SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02213652
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02195646
124MAF_26560356_Chip-Seq_TH1_Human1.01673458
125FLI1_21867929_ChIP-Seq_CD8_Mouse1.01537443
126OCT4_20526341_ChIP-Seq_ESCs_Human1.01392571
127UTX_26944678_Chip-Seq_JUKART_Human1.00268827
128RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00063227
129MYB_26560356_Chip-Seq_TH1_Human0.99971032
130NANOG_20526341_ChIP-Seq_ESCs_Human0.99549359
131ETS1_21867929_ChIP-Seq_TH2_Mouse0.99443853
132TCF7_22412390_ChIP-Seq_EML_Mouse0.99325363
133IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99167237
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98251938
135ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97517366
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97422714
137KLF4_19829295_ChIP-Seq_ESCs_Human0.96879640
138BCL6_27268052_Chip-Seq_Bcells_Human0.96584481
139ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96352035
140RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96311717
141JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96188299
142FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95177498
143SOX11_22085726_ChIP-Seq_ESNs_Mouse0.94749935
144ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94645217
145FOXP1_21924763_ChIP-Seq_HESCs_Human0.94504260
146RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94357184
147ERG_20517297_ChIP-Seq_VCAP_Human0.94343646
148KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93239929
149SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93067636
150MYC_27129775_Chip-Seq_CORNEA_Mouse0.92930173
151SOX2_21211035_ChIP-Seq_LN229_Human0.92574370
152TAF2_19829295_ChIP-Seq_ESCs_Human0.91306910
153TP53_23651856_ChIP-Seq_MEFs_Mouse0.91295115
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90975880
155PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90100949
156CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89729932
157ESET_19884257_ChIP-Seq_ESCs_Mouse0.88914788
158LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87810150
159STAT1_20625510_ChIP-Seq_HELA_Human0.87768386
160MYC_22102868_ChIP-Seq_BL_Human0.87474692
161E2F1_20622854_ChIP-Seq_HELA_Human0.84895930
162CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83627095
163CBP_20019798_ChIP-Seq_JUKART_Human0.82552658
164IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82552658
165EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82511279
166TP63_22573176_ChIP-Seq_HFKS_Human0.82290262
167P68_20966046_ChIP-Seq_HELA_Human0.81946990
168SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81738682
169RAC3_21632823_ChIP-Seq_H3396_Human0.80890493
170P300_27268052_Chip-Seq_Bcells_Human0.80817721
171SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80731567

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.91295695
2MP0001929_abnormal_gametogenesis4.73265858
3MP0001348_abnormal_lacrimal_gland3.72246483
4MP0008877_abnormal_DNA_methylation3.66112567
5MP0002210_abnormal_sex_determination3.00776869
6MP0002249_abnormal_larynx_morphology2.87981671
7MP0005670_abnormal_white_adipose2.77722489
8MP0002161_abnormal_fertility/fecundity2.69165448
9MP0001145_abnormal_male_reproductive2.64046267
10MP0010234_abnormal_vibrissa_follicle2.59550044
11MP0002653_abnormal_ependyma_morphology2.51108638
12MP0003172_abnormal_lysosome_physiology2.46684450
13MP0005451_abnormal_body_composition2.27089821
14MP0000653_abnormal_sex_gland2.26206753
15MP0002132_abnormal_respiratory_system2.23650961
16MP0005410_abnormal_fertilization12.8700664
17MP0003879_abnormal_hair_cell1.95820911
18MP0005058_abnormal_lysosome_morphology1.81299020
19MP0002822_catalepsy1.79755719
20MP0004510_myositis1.77337108
21MP0005083_abnormal_biliary_tract1.63382419
22MP0000566_synostosis1.61328718
23MP0008058_abnormal_DNA_repair1.60565509
24MP0002138_abnormal_hepatobiliary_system1.59563856
25MP0002160_abnormal_reproductive_system1.58009074
26MP0003705_abnormal_hypodermis_morpholog1.45355454
27MP0005409_darkened_coat_color1.37996512
28MP0004264_abnormal_extraembryonic_tissu1.35021666
29MP0005248_abnormal_Harderian_gland1.31723047
30MP0002234_abnormal_pharynx_morphology1.27112897
31MP0005310_abnormal_salivary_gland1.26481075
32MP0002693_abnormal_pancreas_physiology1.25149139
33MP0010094_abnormal_chromosome_stability1.23847677
34MP0003111_abnormal_nucleus_morphology1.22682826
35MP0000681_abnormal_thyroid_gland1.22445376
36MP0008057_abnormal_DNA_replication1.21757643
37MP0000003_abnormal_adipose_tissue1.18544077
38MP0002837_dystrophic_cardiac_calcinosis1.17478996
39MP0001765_abnormal_ion_homeostasis1.16225461
40MP0010352_gastrointestinal_tract_polyps1.13678160
41MP0003436_decreased_susceptibility_to1.12677508
42MP0002928_abnormal_bile_duct1.12526610
43MP0004957_abnormal_blastocyst_morpholog1.10177217
44MP0003283_abnormal_digestive_organ1.08574532
45MP0005365_abnormal_bile_salt1.08447955
46MP0004859_abnormal_synaptic_plasticity1.08417699
47MP0004043_abnormal_pH_regulation1.06876956
48MP0003091_abnormal_cell_migration1.05335349
49MP0002139_abnormal_hepatobiliary_system1.04255771
50MP0000026_abnormal_inner_ear1.03957182
51MP0005389_reproductive_system_phenotype1.03597829
52MP0001944_abnormal_pancreas_morphology1.02067295
53MP0009053_abnormal_anal_canal1.01810754
54MP0004947_skin_inflammation1.01648247
55MP0008995_early_reproductive_senescence1.01434670
56MP0000534_abnormal_ureter_morphology0.99896600
57MP0000685_abnormal_immune_system0.99305706
58MP0001293_anophthalmia0.98634554
59MP0001485_abnormal_pinna_reflex0.96981691
60MP0001730_embryonic_growth_arrest0.95248725
61MP0003763_abnormal_thymus_physiology0.92207702
62MP0005076_abnormal_cell_differentiation0.91939800
63MP0003045_fibrosis0.91839388
64MP0002282_abnormal_trachea_morphology0.91508006
65MP0003693_abnormal_embryo_hatching0.90089542
66MP0005360_urolithiasis0.89455279
67MP0009115_abnormal_fat_cell0.88462601
68MP0005220_abnormal_exocrine_pancreas0.88128578
69MP0003077_abnormal_cell_cycle0.86490405
70MP0004133_heterotaxia0.84742431
71MP0002932_abnormal_joint_morphology0.82656133
72MP0003115_abnormal_respiratory_system0.82525297
73MP0003453_abnormal_keratinocyte_physiol0.81715087
74MP0002127_abnormal_cardiovascular_syste0.81458047
75MP0001963_abnormal_hearing_physiology0.79628827
76MP0003786_premature_aging0.78562302
77MP0009278_abnormal_bone_marrow0.78499197
78MP0004742_abnormal_vestibular_system0.77019611
79MP0003123_paternal_imprinting0.76511464
80MP0010307_abnormal_tumor_latency0.75116392
81MP0005636_abnormal_mineral_homeostasis0.74498614
82MP0002796_impaired_skin_barrier0.73051234
83MP0003011_delayed_dark_adaptation0.72983957
84MP0002933_joint_inflammation0.72648600
85MP0000678_abnormal_parathyroid_gland0.72583856
86MP0008961_abnormal_basal_metabolism0.71671413
87MP0002084_abnormal_developmental_patter0.71244318
88MP0004381_abnormal_hair_follicle0.71172814
89MP0008007_abnormal_cellular_replicative0.70648375
90MP0001666_abnormal_nutrient_absorption0.69909424
91MP0002998_abnormal_bone_remodeling0.69822772
92MP0009840_abnormal_foam_cell0.69649045
93MP0002254_reproductive_system_inflammat0.69542460
94MP0000358_abnormal_cell_content/0.68986364
95MP0003252_abnormal_bile_duct0.68903047
96MP0004233_abnormal_muscle_weight0.68033956
97MP0005666_abnormal_adipose_tissue0.66113629
98MP0003119_abnormal_digestive_system0.65988670
99MP0005394_taste/olfaction_phenotype0.64796234
100MP0005499_abnormal_olfactory_system0.64796234
101MP0000470_abnormal_stomach_morphology0.63830629
102MP0001849_ear_inflammation0.63248957
103MP0009643_abnormal_urine_homeostasis0.62860675
104MP0001764_abnormal_homeostasis0.61407709
105MP0003890_abnormal_embryonic-extraembry0.59979061
106MP0001545_abnormal_hematopoietic_system0.59530671
107MP0005397_hematopoietic_system_phenotyp0.59530671
108MP0003300_gastrointestinal_ulcer0.59290398
109MP0000049_abnormal_middle_ear0.58366035
110MP0005375_adipose_tissue_phenotype0.57449080
111MP0008260_abnormal_autophagy0.57333794
112MP0009672_abnormal_birth_weight0.57085373
113MP0001672_abnormal_embryogenesis/_devel0.56963630
114MP0005380_embryogenesis_phenotype0.56963630
115MP0001835_abnormal_antigen_presentation0.56843819
116MP0009384_cardiac_valve_regurgitation0.56741120
117MP0003303_peritoneal_inflammation0.56680532
118MP0005423_abnormal_somatic_nervous0.56404584
119MP0005647_abnormal_sex_gland0.56262474
120MP0001697_abnormal_embryo_size0.55971961
121MP0002168_other_aberrant_phenotype0.55457622
122MP0005377_hearing/vestibular/ear_phenot0.54894886
123MP0003878_abnormal_ear_physiology0.54894886
124MP0001873_stomach_inflammation0.54560285
125MP0000703_abnormal_thymus_morphology0.53852127
126MP0004858_abnormal_nervous_system0.53728645
127MP0002229_neurodegeneration0.53310244
128MP0000955_abnormal_spinal_cord0.53133512
129MP0003942_abnormal_urinary_system0.52998590
130MP0005535_abnormal_body_temperature0.52888711
131MP0001270_distended_abdomen0.52683250
132MP0001800_abnormal_humoral_immune0.52446974
133MP0000313_abnormal_cell_death0.52123741
134MP0008004_abnormal_stomach_pH0.51674955
135MP0001486_abnormal_startle_reflex0.50814258
136MP0002398_abnormal_bone_marrow0.50776364
137MP0000733_abnormal_muscle_development0.50743716
138MP0002080_prenatal_lethality0.50040580
139MP0004782_abnormal_surfactant_physiolog0.49891385
140MP0006072_abnormal_retinal_apoptosis0.49432086
141MP0003122_maternal_imprinting0.49421123
142MP0002085_abnormal_embryonic_tissue0.49392329
143MP0003866_abnormal_defecation0.49298979
144MP0003183_abnormal_peptide_metabolism0.49159311
145MP0002098_abnormal_vibrissa_morphology0.48789113
146MP0000249_abnormal_blood_vessel0.48685377
147MP0000609_abnormal_liver_physiology0.48450018
148MP0001790_abnormal_immune_system0.48304545
149MP0005387_immune_system_phenotype0.48304545
150MP0003699_abnormal_female_reproductive0.48215665
151MP0003984_embryonic_growth_retardation0.48166866
152MP0008569_lethality_at_weaning0.47943240
153MP0008874_decreased_physiological_sensi0.47643145
154MP0002019_abnormal_tumor_incidence0.47345894
155MP0002088_abnormal_embryonic_growth/wei0.46674085
156MP0004197_abnormal_fetal_growth/weight/0.45963814
157MP0002877_abnormal_melanocyte_morpholog0.45565893
158MP0000613_abnormal_salivary_gland0.45107898
159MP0003959_abnormal_lean_body0.44952530
160MP0003195_calcinosis0.44577811
161MP0000467_abnormal_esophagus_morphology0.42848860
162MP0003329_amyloid_beta_deposits0.42438212
163MP0002136_abnormal_kidney_physiology0.41606174
164MP0002116_abnormal_craniofacial_bone0.41581332
165MP0002089_abnormal_postnatal_growth/wei0.41525977
166MP0002557_abnormal_social/conspecific_i0.41086000
167MP0003936_abnormal_reproductive_system0.39773002
168MP0001502_abnormal_circadian_rhythm0.39744810

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.75925381
2Abnormal respiratory epithelium morphology (HP:0012253)7.48281863
3Abnormal respiratory motile cilium morphology (HP:0005938)7.48281863
4Chronic bronchitis (HP:0004469)7.07566629
5Nasal polyposis (HP:0100582)6.96823470
6Rhinitis (HP:0012384)6.67042922
7Infertility (HP:0000789)6.45822300
8Severe visual impairment (HP:0001141)5.98724431
9Abnormal ciliary motility (HP:0012262)5.70484168
10Abnormality of the nasal mucosa (HP:0000433)5.56103208
11Bronchitis (HP:0012387)5.35071326
12Bronchiectasis (HP:0002110)4.61201963
13Male infertility (HP:0003251)4.51872558
14Recurrent bronchitis (HP:0002837)4.20074457
15Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.14341064
16Asymmetric septal hypertrophy (HP:0001670)4.10672906
17Nephronophthisis (HP:0000090)3.76291327
18Recurrent sinusitis (HP:0011108)3.73662489
19Recurrent otitis media (HP:0000403)3.57491391
20Abnormal spermatogenesis (HP:0008669)3.56556392
21Abnormality of the aortic arch (HP:0012303)3.36428240
22Hypoplastic ischia (HP:0003175)3.32214665
23Impulsivity (HP:0100710)3.12202552
24Bony spicule pigmentary retinopathy (HP:0007737)3.07316236
25Broad face (HP:0000283)3.02815324
26Resting tremor (HP:0002322)3.02379020
27Abnormality of the renal medulla (HP:0100957)2.95777663
28Atelectasis (HP:0100750)2.85555324
29Obstructive sleep apnea (HP:0002870)2.83302470
30Abnormality of the ischium (HP:0003174)2.83001494
31Molar tooth sign on MRI (HP:0002419)2.78837206
32Abnormality of midbrain morphology (HP:0002418)2.78837206
33Thin bony cortex (HP:0002753)2.74966821
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.70974180
35Enlarged epiphyses (HP:0010580)2.67000047
36Abnormal rod and cone electroretinograms (HP:0008323)2.64886582
3711 pairs of ribs (HP:0000878)2.64542776
38Tubular atrophy (HP:0000092)2.57016928
39Cervical subluxation (HP:0003308)2.56610906
40Hyperthyroidism (HP:0000836)2.50494370
41Attenuation of retinal blood vessels (HP:0007843)2.47547790
42Progressive sensorineural hearing impairment (HP:0000408)2.35128921
43Potter facies (HP:0002009)2.34206971
44Facial shape deformation (HP:0011334)2.34206971
45Chronic hepatic failure (HP:0100626)2.32407481
46Renovascular hypertension (HP:0100817)2.31720754
47Epiphyseal dysplasia (HP:0002656)2.29503621
48Cone-rod dystrophy (HP:0000548)2.27526362
49Nuclear cataract (HP:0100018)2.26898531
50Gonadotropin excess (HP:0000837)2.26826205
51Postural instability (HP:0002172)2.23623670
52J-shaped sella turcica (HP:0002680)2.21285514
53Tubulointerstitial nephritis (HP:0001970)2.19496320
54Colitis (HP:0002583)2.19445678
55Hypoalphalipoproteinemia (HP:0003233)2.18114419
56Focal segmental glomerulosclerosis (HP:0000097)2.16686646
57Protuberant abdomen (HP:0001538)2.16513074
58Azoospermia (HP:0000027)2.14001038
59Aplasia/Hypoplasia of the earlobes (HP:0009906)2.13965875
60Stridor (HP:0010307)2.12743814
61Hypoparathyroidism (HP:0000829)2.12078521
62Seborrheic dermatitis (HP:0001051)2.10821810
63Distal upper limb amyotrophy (HP:0007149)2.08211501
64Upper limb amyotrophy (HP:0009129)2.08211501
65Amelogenesis imperfecta (HP:0000705)2.07162249
66Heterotopia (HP:0002282)2.06522973
67Cystic liver disease (HP:0006706)2.06354212
68Absent epiphyses (HP:0010577)2.05278059
69Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.05278059
70Occipital encephalocele (HP:0002085)2.03005158
71Abnormality of macular pigmentation (HP:0008002)2.02811721
72Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.02387384
73Lymphangioma (HP:0100764)2.01988562
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.3286843
75Dynein arm defect of respiratory motile cilia (HP:0012255)11.0252400
76Absent/shortened dynein arms (HP:0200106)11.0252400
77Tubulointerstitial abnormality (HP:0001969)1.99144325
78Postaxial foot polydactyly (HP:0001830)1.98260522
79Abnormality of the femoral head (HP:0003368)1.97753518
80Facial cleft (HP:0002006)1.96453700
81Congenital hepatic fibrosis (HP:0002612)1.95237669
82Bowel incontinence (HP:0002607)1.94345532
83Widely patent fontanelles and sutures (HP:0004492)1.93394922
84Deformed sella turcica (HP:0002681)1.93218578
85Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.88666204
86Abnormality of dental color (HP:0011073)1.87941197
87Medial flaring of the eyebrow (HP:0010747)1.85612474
88Gingivitis (HP:0000230)1.85108944
89Abnormality of the renal cortex (HP:0011035)1.84819544
90Abnormality of the parathyroid morphology (HP:0011766)1.83632710
91Hypophosphatemia (HP:0002148)1.82609513
92Mixed hearing impairment (HP:0000410)1.82397869
93Hand muscle atrophy (HP:0009130)1.82153169
94Abnormality of the fingertips (HP:0001211)1.82034912
95Flat capital femoral epiphysis (HP:0003370)1.81695326
96Hypertriglyceridemia (HP:0002155)1.81113821
97Metaphyseal cupping (HP:0003021)1.80825536
98Deep palmar crease (HP:0006191)1.80733402
99Tubulointerstitial fibrosis (HP:0005576)1.80727345
100Atrophic scars (HP:0001075)1.80656221
101Cerebral aneurysm (HP:0004944)1.79449630
102Abnormality of the thoracic spine (HP:0100711)1.79395773
103Hypoplasia of the thymus (HP:0000778)1.78144563
104Chronic sinusitis (HP:0011109)1.76931462
105Glomerulosclerosis (HP:0000096)1.76079601
106Abnormality of the epiphysis of the femoral head (HP:0010574)1.74779987
107Menstrual irregularities (HP:0000858)1.73418886
108Abnormality of femoral epiphyses (HP:0006499)1.72512072
109Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.72512072
110Abdominal distention (HP:0003270)1.72004208
111Abnormal large intestine physiology (HP:0012700)1.71431923
112Acanthosis nigricans (HP:0000956)1.71196959
113Stage 5 chronic kidney disease (HP:0003774)1.71092959
114Thoracic kyphosis (HP:0002942)1.70889136
115Oculomotor apraxia (HP:0000657)1.69808219
116Germ cell neoplasia (HP:0100728)1.68834566
117Hyperacusis (HP:0010780)1.67021825
118Flat acetabular roof (HP:0003180)1.66136006
119Abnormality of renal excretion (HP:0011036)1.65338206
120Hyperinsulinemic hypoglycemia (HP:0000825)1.63521751
121Abnormal biliary tract physiology (HP:0012439)1.63090383
122Bile duct proliferation (HP:0001408)1.63090383
123Missing ribs (HP:0000921)1.62392533
124Cholecystitis (HP:0001082)1.62014723
125Abnormal gallbladder physiology (HP:0012438)1.62014723
126Median cleft lip (HP:0000161)1.61277874
127Renal dysplasia (HP:0000110)1.61008010
128Pancreatic fibrosis (HP:0100732)1.60706270
129Hyperkalemia (HP:0002153)1.59507742
130Pili torti (HP:0003777)1.58399517
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.56801834
132Spastic tetraparesis (HP:0001285)1.55520094
133Hemorrhage of the eye (HP:0011885)1.55372377
134Truncal obesity (HP:0001956)1.54442213
135Short ribs (HP:0000773)1.53905081
136Abnormal drinking behavior (HP:0030082)1.51209300
137Polydipsia (HP:0001959)1.51209300
138Choroideremia (HP:0001139)1.50857838
139Hyperphosphatemia (HP:0002905)1.45858721
140Abnormality of the anterior horn cell (HP:0006802)1.44787854
141Degeneration of anterior horn cells (HP:0002398)1.44787854
142True hermaphroditism (HP:0010459)1.43924844
143Vascular calcification (HP:0004934)1.42876773
144Decreased central vision (HP:0007663)1.42583046
145Squamous cell carcinoma (HP:0002860)1.41895523
146Malnutrition (HP:0004395)1.41059950
147Abnormal urine output (HP:0012590)1.40749120
148Cerebellar dysplasia (HP:0007033)1.40368017
149Myoglobinuria (HP:0002913)1.39251354
150Basal cell carcinoma (HP:0002671)1.35454462
151Short thorax (HP:0010306)1.33603672
152Postaxial hand polydactyly (HP:0001162)1.33595279
153Dyschromatopsia (HP:0007641)1.33424745
154Nephropathy (HP:0000112)1.31965884
155Onycholysis (HP:0001806)1.31628208
156Easy fatigability (HP:0003388)1.31622792
157Hypercholesterolemia (HP:0003124)1.31393697
158Milia (HP:0001056)1.30838079
159Pancreatic cysts (HP:0001737)1.30590558
160Hypoplastic labia majora (HP:0000059)1.30549183
161Fibular hypoplasia (HP:0003038)1.29747886
162Bell-shaped thorax (HP:0001591)1.27208331
163Neoplasm of the heart (HP:0100544)1.26655533
164Abnormality of small intestinal villus morphology (HP:0011472)1.24773508
165Villous atrophy (HP:0011473)1.24773508
166Abnormal hair laboratory examination (HP:0003328)1.23211451
167Absent thumb (HP:0009777)1.22266993
168Hypoplasia of dental enamel (HP:0006297)1.21312549
169Hypoplasia of the radius (HP:0002984)1.20906733
170Polyuria (HP:0000103)1.19803086
171Breast carcinoma (HP:0003002)1.19423208
172Rhizomelia (HP:0008905)1.19074158
173Neoplasm of the oral cavity (HP:0100649)1.18613132
174Flattened epiphyses (HP:0003071)1.16841499
175Cardiovascular calcification (HP:0011915)1.15861653
176Abnormality of the labia majora (HP:0012881)1.14052182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.36574644
2PDK36.36574644
3TESK16.17625164
4PRKD35.06606812
5ICK4.30179652
6PDK23.91670443
7DDR23.45999956
8MST1R2.78894061
9NEK22.46774224
10WNK42.35730175
11PASK2.34598109
12DYRK1B2.15617523
13RIPK12.01171487
14MAPK151.76889671
15SIK21.76325425
16EEF2K1.55563965
17FRK1.52075195
18MAP3K131.50696914
19STK381.49846529
20MARK21.49097645
21MAP3K101.48912462
22MAP4K11.47392238
23TNK21.46697112
24DYRK31.46364416
25PTK2B1.39198223
26SMG11.28062830
27PRPF4B1.22110987
28CDK121.21739685
29MAP3K111.16428945
30TESK21.14235183
31RPS6KC11.12103610
32RPS6KL11.12103610
33MAP3K71.11203222
34BRSK21.08907500
35PNCK1.04961935
36STK101.00442881
37CDC70.98602962
38MAP3K10.97799211
39MAP3K90.97355418
40PDK10.93033620
41RPS6KA60.92529101
42STK390.92169024
43BCKDK0.92162494
44MET0.90158766
45KSR20.89914881
46CDK70.85736163
47NEK60.85038299
48LATS10.84433069
49WEE10.80617034
50LATS20.78959711
51STK30.77149579
52ZAP700.76322715
53ATR0.76188835
54ERN10.75927346
55MAP2K60.75583252
56TTK0.73901777
57MAP4K20.73866508
58CAMK1D0.72114779
59MUSK0.70708678
60MAPKAPK30.70470817
61MTOR0.70025524
62IRAK10.69842693
63MAP3K60.66088595
64TAOK30.65003950
65CHEK10.64096897
66WNK10.63323533
67FGFR40.59144512
68CAMK1G0.57665839
69ATM0.57536152
70MARK30.57210285
71MAP3K30.56713136
72BMX0.56524412
73PRKG20.56505442
74JAK30.56405877
75PTK60.56115787
76PKN20.55231794
77MAPK80.54932086
78CAMKK10.54715010
79PRKD20.54569557
80NME10.53688192
81BLK0.53185385
82BRD40.53094967
83EPHA20.52450981
84ARAF0.50541918
85CHEK20.49692295
86TRIB30.48215677
87SGK2230.48037705
88SGK4940.48037705
89MAPK10.47824154
90PAK40.47273118
91ACVR1B0.47159784
92TBK10.47102601
93MAP2K30.46142993
94GRK60.45698640
95FLT30.44716086
96ROCK10.44591440
97EPHB10.44254751
98PDGFRA0.44035613
99RET0.43606105
100RPS6KA40.42906361
101TYRO30.42806380
102CDC42BPA0.41817864
103HIPK20.41654469
104PRKAA20.41016710
105NTRK30.40086926
106PIM10.39911744
107CDK60.39781373
108BTK0.39346660
109TYK20.39049502
110SGK30.39032089
111UHMK10.37946299
112PLK10.37133856
113PDPK10.37084687
114CCNB10.37057786
115BRSK10.36704027
116MAP2K20.36666273
117CDK40.36141924
118GSK3B0.35390576
119MAP3K80.34822860
120PRKCZ0.34813349
121MAPK100.33901672
122RIPK40.33827118
123BRAF0.31585889
124ITK0.31115419
125AURKB0.30099027
126RPS6KB20.29554951
127PAK10.28677021
128IRAK30.28094535
129RPS6KA10.28046405
130PAK20.26128968
131CDK20.25174623
132STK38L0.25051640
133PRKAA10.24584230
134CHUK0.23433722
135PRKCQ0.22740843
136PRKCI0.22535873
137PLK40.22140164
138PTK20.21965817
139RPS6KB10.21907565
140NLK0.21728796
141RPS6KA20.21426582
142SIK10.20300453
143INSRR0.18747137
144CDK90.18542675
145CSF1R0.17768486
146MAP3K140.17088484
147LRRK20.16719790
148CSNK2A10.16142411
149TAOK20.15845792
150CSK0.15494833
151MAP3K20.14945585
152CSNK2A20.13970729

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.45878024
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.31816093
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.30387076
4Selenocompound metabolism_Homo sapiens_hsa004503.03296834
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81345205
6Fatty acid biosynthesis_Homo sapiens_hsa000612.68926022
7Linoleic acid metabolism_Homo sapiens_hsa005912.64060315
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61210680
9Pyruvate metabolism_Homo sapiens_hsa006202.56603510
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.44539484
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.38385049
12Notch signaling pathway_Homo sapiens_hsa043302.32603086
13Protein export_Homo sapiens_hsa030602.30191769
14Glucagon signaling pathway_Homo sapiens_hsa049222.10741399
15Antigen processing and presentation_Homo sapiens_hsa046122.06706714
16Basal transcription factors_Homo sapiens_hsa030221.98150191
17Fat digestion and absorption_Homo sapiens_hsa049751.97890403
18Acute myeloid leukemia_Homo sapiens_hsa052211.79170232
19Pentose phosphate pathway_Homo sapiens_hsa000301.69729349
20Glycerolipid metabolism_Homo sapiens_hsa005611.68812390
21RNA transport_Homo sapiens_hsa030131.68617012
22Propanoate metabolism_Homo sapiens_hsa006401.68566645
23mRNA surveillance pathway_Homo sapiens_hsa030151.64626276
24Fructose and mannose metabolism_Homo sapiens_hsa000511.64376459
25Fanconi anemia pathway_Homo sapiens_hsa034601.63050387
26Vitamin B6 metabolism_Homo sapiens_hsa007501.43670292
27Olfactory transduction_Homo sapiens_hsa047401.40452595
28DNA replication_Homo sapiens_hsa030301.40445673
29Phenylalanine metabolism_Homo sapiens_hsa003601.38028151
30Type II diabetes mellitus_Homo sapiens_hsa049301.37807936
31Fatty acid degradation_Homo sapiens_hsa000711.36058457
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.27301630
33Choline metabolism in cancer_Homo sapiens_hsa052311.26689531
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.23876176
35N-Glycan biosynthesis_Homo sapiens_hsa005101.22649124
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21943707
37Homologous recombination_Homo sapiens_hsa034401.21304331
38Dorso-ventral axis formation_Homo sapiens_hsa043201.17266732
39Endocytosis_Homo sapiens_hsa041441.16814507
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15854674
41Mismatch repair_Homo sapiens_hsa034301.15109723
42Inositol phosphate metabolism_Homo sapiens_hsa005621.14416782
43PPAR signaling pathway_Homo sapiens_hsa033201.12915127
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10855881
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09552100
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08859615
47Base excision repair_Homo sapiens_hsa034101.08518681
48mTOR signaling pathway_Homo sapiens_hsa041501.06191306
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04148449
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.04130449
51ABC transporters_Homo sapiens_hsa020101.04034021
52Carbon metabolism_Homo sapiens_hsa012001.03796265
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03560519
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.01295303
55Non-small cell lung cancer_Homo sapiens_hsa052231.00566148
56Prolactin signaling pathway_Homo sapiens_hsa049170.99551263
57Sulfur metabolism_Homo sapiens_hsa009200.99122795
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97052356
59Insulin signaling pathway_Homo sapiens_hsa049100.96557580
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96402294
61Pyrimidine metabolism_Homo sapiens_hsa002400.93982587
62Endometrial cancer_Homo sapiens_hsa052130.90072586
63Chronic myeloid leukemia_Homo sapiens_hsa052200.89758886
64ErbB signaling pathway_Homo sapiens_hsa040120.89469705
65Fatty acid metabolism_Homo sapiens_hsa012120.89406291
66Biosynthesis of amino acids_Homo sapiens_hsa012300.88790378
67Spliceosome_Homo sapiens_hsa030400.88705178
68Primary immunodeficiency_Homo sapiens_hsa053400.87620690
69Allograft rejection_Homo sapiens_hsa053300.87513613
70Mineral absorption_Homo sapiens_hsa049780.86483577
71Hedgehog signaling pathway_Homo sapiens_hsa043400.86306675
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84964854
73Glutathione metabolism_Homo sapiens_hsa004800.84047773
74Basal cell carcinoma_Homo sapiens_hsa052170.83052911
75Purine metabolism_Homo sapiens_hsa002300.82748037
76Arginine biosynthesis_Homo sapiens_hsa002200.81814591
77Osteoclast differentiation_Homo sapiens_hsa043800.81788399
78MAPK signaling pathway_Homo sapiens_hsa040100.81639237
79Autoimmune thyroid disease_Homo sapiens_hsa053200.80461259
80B cell receptor signaling pathway_Homo sapiens_hsa046620.78979945
81Folate biosynthesis_Homo sapiens_hsa007900.78829621
82Other glycan degradation_Homo sapiens_hsa005110.76219735
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75842867
84Legionellosis_Homo sapiens_hsa051340.75790943
85Graft-versus-host disease_Homo sapiens_hsa053320.75458015
86Bile secretion_Homo sapiens_hsa049760.74345751
87Oocyte meiosis_Homo sapiens_hsa041140.71335000
88RNA degradation_Homo sapiens_hsa030180.71307368
89Bladder cancer_Homo sapiens_hsa052190.70855562
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70662549
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70446234
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70406230
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.70020515
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68877469
95T cell receptor signaling pathway_Homo sapiens_hsa046600.67417273
96Pancreatic secretion_Homo sapiens_hsa049720.66888285
97Insulin secretion_Homo sapiens_hsa049110.66035251
98Galactose metabolism_Homo sapiens_hsa000520.65825662
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65365469
100Ether lipid metabolism_Homo sapiens_hsa005650.65147365
101Axon guidance_Homo sapiens_hsa043600.64144395
102Thyroid hormone synthesis_Homo sapiens_hsa049180.63144341
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63014706
104Insulin resistance_Homo sapiens_hsa049310.62995048
105Cell cycle_Homo sapiens_hsa041100.62522480
106GnRH signaling pathway_Homo sapiens_hsa049120.62308771
107Lysine degradation_Homo sapiens_hsa003100.62121488
108Viral myocarditis_Homo sapiens_hsa054160.61141121
109TNF signaling pathway_Homo sapiens_hsa046680.60803622
110Herpes simplex infection_Homo sapiens_hsa051680.59162257
111Chemical carcinogenesis_Homo sapiens_hsa052040.58586573
112Prostate cancer_Homo sapiens_hsa052150.57952074
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57442063
114Prion diseases_Homo sapiens_hsa050200.57034917
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.55834045
116Chemokine signaling pathway_Homo sapiens_hsa040620.55722322
117Focal adhesion_Homo sapiens_hsa045100.55600601
118Type I diabetes mellitus_Homo sapiens_hsa049400.53615021
119Epstein-Barr virus infection_Homo sapiens_hsa051690.53511300
120Tryptophan metabolism_Homo sapiens_hsa003800.53123063
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.52538183
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50781171
123Glioma_Homo sapiens_hsa052140.50667269
124Renin-angiotensin system_Homo sapiens_hsa046140.50618217
125p53 signaling pathway_Homo sapiens_hsa041150.49907373
126ECM-receptor interaction_Homo sapiens_hsa045120.49713612
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.49163455
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.49095349
129Tight junction_Homo sapiens_hsa045300.48725908
130Renal cell carcinoma_Homo sapiens_hsa052110.47775419
131Viral carcinogenesis_Homo sapiens_hsa052030.47562473
132Protein digestion and absorption_Homo sapiens_hsa049740.47405563
133Hepatitis C_Homo sapiens_hsa051600.47074351
134Arginine and proline metabolism_Homo sapiens_hsa003300.46944162
135Pancreatic cancer_Homo sapiens_hsa052120.46359996
136Taste transduction_Homo sapiens_hsa047420.46066253
137Tyrosine metabolism_Homo sapiens_hsa003500.46048901
138Measles_Homo sapiens_hsa051620.45124999
139Melanogenesis_Homo sapiens_hsa049160.44038995
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43889410
141Leishmaniasis_Homo sapiens_hsa051400.43556734
142Thyroid cancer_Homo sapiens_hsa052160.43248911
143AMPK signaling pathway_Homo sapiens_hsa041520.43035414
144Amphetamine addiction_Homo sapiens_hsa050310.42323518
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42306222
146HIF-1 signaling pathway_Homo sapiens_hsa040660.41732692
147Arachidonic acid metabolism_Homo sapiens_hsa005900.41534863
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41309117
149Influenza A_Homo sapiens_hsa051640.41035503
150HTLV-I infection_Homo sapiens_hsa051660.40672255
151Nucleotide excision repair_Homo sapiens_hsa034200.38063315
152Toxoplasmosis_Homo sapiens_hsa051450.37903561
153Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37487473
154Cyanoamino acid metabolism_Homo sapiens_hsa004600.36018955
155VEGF signaling pathway_Homo sapiens_hsa043700.34243959
156Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.31060880
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29910256
158NF-kappa B signaling pathway_Homo sapiens_hsa040640.27765196
159Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26667050
160Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25919864
161Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25579110
162Non-homologous end-joining_Homo sapiens_hsa034500.24689375
163Estrogen signaling pathway_Homo sapiens_hsa049150.24485001

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