LMO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1suckling behavior (GO:0001967)7.17586408
2positive regulation of megakaryocyte differentiation (GO:0045654)6.05120466
3multicellular organismal aging (GO:0010259)5.97216445
4negative regulation of cytosolic calcium ion concentration (GO:0051481)5.93055458
5protein K6-linked ubiquitination (GO:0085020)5.59828999
6DNA replication checkpoint (GO:0000076)5.26455767
7dendritic spine morphogenesis (GO:0060997)5.13216932
8regulation of meiosis (GO:0040020)5.10542918
9intra-S DNA damage checkpoint (GO:0031573)5.01475633
10positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.98635819
11DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.61420378
12pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.57556823
13regulation of histone H3-K27 methylation (GO:0061085)4.55609209
14DNA damage response, signal transduction resulting in transcription (GO:0042772)4.54181263
15regulation of meiosis I (GO:0060631)4.51944378
16negative regulation of hormone metabolic process (GO:0032351)4.44588271
17negative regulation of hormone biosynthetic process (GO:0032353)4.44588271
18heterochromatin organization (GO:0070828)4.40850635
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.40555608
20negative regulation of cell killing (GO:0031342)4.40555608
21mitotic metaphase plate congression (GO:0007080)4.34340122
22chromatin remodeling at centromere (GO:0031055)4.27179955
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.26326025
24rRNA methylation (GO:0031167)4.08393898
25piRNA metabolic process (GO:0034587)4.07933003
26neuron fate determination (GO:0048664)4.05691647
27regulation of timing of cell differentiation (GO:0048505)4.04514562
28regulation of meiotic cell cycle (GO:0051445)4.03179048
29protein K11-linked ubiquitination (GO:0070979)3.98057836
30spinal cord association neuron differentiation (GO:0021527)3.95559987
31rRNA modification (GO:0000154)3.95243813
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.90844520
33resolution of meiotic recombination intermediates (GO:0000712)3.89716857
34behavioral response to nicotine (GO:0035095)3.85903221
35nonmotile primary cilium assembly (GO:0035058)3.82990340
36regulation of female gonad development (GO:2000194)3.81609657
37mitotic sister chromatid segregation (GO:0000070)3.79899565
38type B pancreatic cell development (GO:0003323)3.77681600
39auditory receptor cell differentiation (GO:0042491)3.76906387
40cell differentiation in spinal cord (GO:0021515)3.75436858
41male meiosis (GO:0007140)3.74077380
42regulation of exit from mitosis (GO:0007096)3.73941179
43kinetochore assembly (GO:0051382)3.69003263
44generation of neurons (GO:0048699)3.68457383
45inositol phosphate catabolic process (GO:0071545)3.65697424
46regulation of glucocorticoid metabolic process (GO:0031943)3.63698802
47negative regulation of meiosis (GO:0045835)3.62548515
48regulation of DNA methylation (GO:0044030)3.61566268
49female gamete generation (GO:0007292)3.60699786
50pre-miRNA processing (GO:0031054)3.59546088
51pyrimidine nucleotide catabolic process (GO:0006244)3.59455197
52negative regulation of circadian rhythm (GO:0042754)3.59270381
53spinal cord motor neuron differentiation (GO:0021522)3.57978209
54retinal ganglion cell axon guidance (GO:0031290)3.57480556
55pyrimidine nucleobase catabolic process (GO:0006208)3.57376583
56apoptotic DNA fragmentation (GO:0006309)3.56920451
57calcium ion import (GO:0070509)3.56490096
58meiotic cell cycle (GO:0051321)3.53077271
59metaphase plate congression (GO:0051310)3.49638451
60protein complex localization (GO:0031503)3.40637030
61microtubule nucleation (GO:0007020)3.39811620
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39201918
63vascular smooth muscle contraction (GO:0014829)3.38816673
64replication fork processing (GO:0031297)3.35508264
65oocyte maturation (GO:0001556)3.34319311
66establishment of chromosome localization (GO:0051303)3.32607261
67mitotic chromosome condensation (GO:0007076)3.32033967
68cerebral cortex neuron differentiation (GO:0021895)3.30529762
69presynaptic membrane assembly (GO:0097105)3.29729108
70single strand break repair (GO:0000012)3.27931341
71water-soluble vitamin biosynthetic process (GO:0042364)3.27509112
72maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.27034340
73nucleobase catabolic process (GO:0046113)3.26768436
74acrosome reaction (GO:0007340)3.26412319
75chaperone-mediated protein transport (GO:0072321)3.25731445
76kinetochore organization (GO:0051383)3.18704703
77CENP-A containing nucleosome assembly (GO:0034080)3.17431432
78DNA damage induced protein phosphorylation (GO:0006975)3.16913821
79regulation of centriole replication (GO:0046599)3.16474580
80notochord development (GO:0030903)3.15681372
81ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.14889131
82positive regulation of mitochondrial fission (GO:0090141)3.14431607
83sister chromatid segregation (GO:0000819)3.13270865
84positive regulation of oligodendrocyte differentiation (GO:0048714)3.13176036
85calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.08919028
86negative regulation of cell aging (GO:0090344)3.08533850
87axonal fasciculation (GO:0007413)3.04490510
88positive regulation of glycolytic process (GO:0045821)3.04342152
89gamma-aminobutyric acid transport (GO:0015812)3.04239328
90chromosome segregation (GO:0007059)3.02132132
91detection of light stimulus involved in sensory perception (GO:0050962)3.01115847
92detection of light stimulus involved in visual perception (GO:0050908)3.01115847
93regulation of glucokinase activity (GO:0033131)3.00038953
94regulation of hexokinase activity (GO:1903299)3.00038953
95histone exchange (GO:0043486)2.99634014
96central nervous system projection neuron axonogenesis (GO:0021952)2.99189416
97cell migration in hindbrain (GO:0021535)2.98787952
98regulation of cell maturation (GO:1903429)2.97623198
99regulation of cilium movement (GO:0003352)2.97542902
100glycerophospholipid catabolic process (GO:0046475)2.96747285
101base-excision repair, AP site formation (GO:0006285)2.95942383
102forebrain neuron differentiation (GO:0021879)2.95647979
103synaptic transmission, cholinergic (GO:0007271)2.95544226
104polyol catabolic process (GO:0046174)2.94359991
105central nervous system neuron axonogenesis (GO:0021955)2.92627299
106neuronal stem cell maintenance (GO:0097150)2.92428798
107regulation of short-term neuronal synaptic plasticity (GO:0048172)2.91454580
108presynaptic membrane organization (GO:0097090)2.90192198
109chromatin assembly or disassembly (GO:0006333)2.88929848
110meiosis I (GO:0007127)2.88544191
111lens morphogenesis in camera-type eye (GO:0002089)2.88354722
112regulation of oligodendrocyte differentiation (GO:0048713)2.88135606
113neuronal action potential (GO:0019228)2.87917494
114negative regulation of smooth muscle cell differentiation (GO:0051151)2.85921288
115positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.85133599
116neural tube formation (GO:0001841)2.84747136
117olfactory bulb development (GO:0021772)2.84679049
118negative regulation of meiotic cell cycle (GO:0051447)2.84133699
119attachment of spindle microtubules to kinetochore (GO:0008608)2.83520277
120snRNA transcription (GO:0009301)2.82719090
121axoneme assembly (GO:0035082)2.82512854
122negative regulation of cell cycle arrest (GO:0071157)2.82079341
123negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81225139
124photoreceptor cell maintenance (GO:0045494)2.81099952
125intraciliary transport (GO:0042073)2.80228427
126myoblast migration (GO:0051451)2.80018098
127establishment of mitochondrion localization (GO:0051654)2.79486276
128negative regulation of DNA-templated transcription, elongation (GO:0032785)2.79411065
129negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.79411065
130response to pheromone (GO:0019236)2.78382101
131regulation of energy homeostasis (GO:2000505)2.77057593
132ovulation cycle (GO:0042698)2.76539912
133neuron fate specification (GO:0048665)2.75846668
134synapse assembly (GO:0007416)2.75180033
1353-UTR-mediated mRNA stabilization (GO:0070935)2.74756963
136female gonad development (GO:0008585)2.74566915
137glandular epithelial cell development (GO:0002068)2.73123997
138postsynaptic membrane organization (GO:0001941)2.72967523
139DNA replication-independent nucleosome assembly (GO:0006336)2.71801195
140DNA replication-independent nucleosome organization (GO:0034724)2.71801195
141positive regulation of DNA-dependent DNA replication (GO:2000105)2.71173632
142meiotic chromosome segregation (GO:0045132)2.70943932
143maturation of 5.8S rRNA (GO:0000460)2.69868907
144regulation of RIG-I signaling pathway (GO:0039535)2.68985165
145respiratory system process (GO:0003016)2.68610207
146transmission of nerve impulse (GO:0019226)2.68579957
147forebrain neuron development (GO:0021884)2.68477859
148regulation of double-strand break repair via homologous recombination (GO:0010569)2.68276298
149protein localization to cilium (GO:0061512)2.67386355
150kidney morphogenesis (GO:0060993)2.66739921
151positive regulation of growth hormone secretion (GO:0060124)2.66385205
152regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.66030056
153regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.66030056
154regulation of development, heterochronic (GO:0040034)2.64603019
155spindle checkpoint (GO:0031577)2.64138550
156regulation of transforming growth factor beta2 production (GO:0032909)2.64068931
157neuron recognition (GO:0008038)2.63260367
158pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.63258576
159proline transport (GO:0015824)2.61854282
160protein polyglutamylation (GO:0018095)2.61780278
161regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61450627
162histone H2A ubiquitination (GO:0033522)2.61124982
163cilium assembly (GO:0042384)2.60921989
164ganglion development (GO:0061548)2.60738394
165cellular ketone body metabolic process (GO:0046950)2.60511915
166endocrine pancreas development (GO:0031018)2.58427070
167cilium morphogenesis (GO:0060271)2.57872709
168reflex (GO:0060004)2.57649519
169epithelial cilium movement (GO:0003351)2.57382244
170cilium organization (GO:0044782)2.57128425
171negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56320008
172protein K11-linked deubiquitination (GO:0035871)2.55653949
173dendritic spine organization (GO:0097061)2.55524365
174astrocyte differentiation (GO:0048708)2.50455267
175microtubule polymerization or depolymerization (GO:0031109)2.50352551
176calcium ion-dependent exocytosis (GO:0017156)2.49566086
177left/right axis specification (GO:0070986)2.49158396
178epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.48387126
179adult feeding behavior (GO:0008343)2.45968525
180limb bud formation (GO:0060174)2.45152642
181protein localization to synapse (GO:0035418)2.44791954
182neuron cell-cell adhesion (GO:0007158)2.44338024
183regulation of feeding behavior (GO:0060259)2.43059957
184brain morphogenesis (GO:0048854)2.41326286
185dentate gyrus development (GO:0021542)2.40358723
186mitochondrion transport along microtubule (GO:0047497)2.39436331
187establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.39436331
188positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.38940552
189regulation of calcium ion-dependent exocytosis (GO:0017158)2.37256569
190regulation of microtubule-based movement (GO:0060632)2.36230323
191pteridine-containing compound biosynthetic process (GO:0042559)2.35739843
192ncRNA catabolic process (GO:0034661)2.35215958
193epithelial cell fate commitment (GO:0072148)2.33792958
194neuromuscular synaptic transmission (GO:0007274)2.33425195
195behavioral defense response (GO:0002209)2.32735048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.84622322
2EZH2_22144423_ChIP-Seq_EOC_Human4.11370759
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.70193020
4E2F7_22180533_ChIP-Seq_HELA_Human3.49214265
5MYC_18940864_ChIP-ChIP_HL60_Human2.99866657
6GBX2_23144817_ChIP-Seq_PC3_Human2.86436485
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79312652
8ZNF274_21170338_ChIP-Seq_K562_Hela2.61960924
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.61133649
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60388681
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54817903
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50467849
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.40460047
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.40446994
15IGF1R_20145208_ChIP-Seq_DFB_Human2.32049913
16MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.31622523
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27087137
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24183986
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17238816
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16620795
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16620795
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06802038
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02781128
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99774549
25KAP1_22055183_ChIP-Seq_ESCs_Mouse1.97787082
26RNF2_27304074_Chip-Seq_NSC_Mouse1.91927216
27* EZH2_27304074_Chip-Seq_ESCs_Mouse1.91811762
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86535613
29FUS_26573619_Chip-Seq_HEK293_Human1.86478672
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86464009
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.84907921
32VDR_22108803_ChIP-Seq_LS180_Human1.79809177
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79366996
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77142689
35P300_19829295_ChIP-Seq_ESCs_Human1.76600803
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.74085149
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.73913575
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72346021
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.71524502
40AR_21909140_ChIP-Seq_LNCAP_Human1.71257096
41* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69747234
42TAF15_26573619_Chip-Seq_HEK293_Human1.66882738
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.66805490
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65923727
45* RNF2_27304074_Chip-Seq_ESCs_Mouse1.65463874
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.62346998
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.60927777
48SMAD4_21799915_ChIP-Seq_A2780_Human1.58518011
49* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57410593
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56920439
51CBP_20019798_ChIP-Seq_JUKART_Human1.56920439
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56413259
53* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56071210
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55169061
55P53_22127205_ChIP-Seq_FIBROBLAST_Human1.55012825
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52618134
57CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51013119
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.50402261
59* EZH2_27294783_Chip-Seq_ESCs_Mouse1.49904417
60* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49866170
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.49189046
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48600713
63HTT_18923047_ChIP-ChIP_STHdh_Human1.47104946
64EWS_26573619_Chip-Seq_HEK293_Human1.43037897
65LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42329437
66AR_21572438_ChIP-Seq_LNCaP_Human1.42249541
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40180213
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38226735
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38226735
70ZNF263_19887448_ChIP-Seq_K562_Human1.34967197
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34369809
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34350425
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34084393
74STAT3_23295773_ChIP-Seq_U87_Human1.33940065
75* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33600012
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33504849
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31695896
78* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31227116
79TP53_22573176_ChIP-Seq_HFKS_Human1.30834720
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29892150
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29756801
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29165089
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28482615
84BCAT_22108803_ChIP-Seq_LS180_Human1.28200872
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28195237
86AR_25329375_ChIP-Seq_VCAP_Human1.28123862
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26952100
88IRF1_19129219_ChIP-ChIP_H3396_Human1.26893611
89* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26828750
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26465093
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25540760
92* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23890853
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23887363
94* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21429832
95* RING1B_27294783_Chip-Seq_NPCs_Mouse1.21308167
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20693231
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.20656071
98* RUNX2_22187159_ChIP-Seq_PCA_Human1.20573256
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20461572
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20385594
101* TCF4_23295773_ChIP-Seq_U87_Human1.16376637
102* RING1B_27294783_Chip-Seq_ESCs_Mouse1.16336592
103* REST_21632747_ChIP-Seq_MESCs_Mouse1.15322740
104KDM2B_26808549_Chip-Seq_K562_Human1.14873565
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13744237
106ESR1_20079471_ChIP-ChIP_T-47D_Human1.13255387
107* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11931907
108* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11886791
109ER_23166858_ChIP-Seq_MCF-7_Human1.11653649
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11091423
111ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10884748
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10580889
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10492246
114ELK4_26923725_Chip-Seq_MESODERM_Mouse1.10271148
115* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09226202
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.08853056
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08660182
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06883455
119* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06183059
120TAL1_26923725_Chip-Seq_HPCs_Mouse1.04893575
121EST1_17652178_ChIP-ChIP_JURKAT_Human1.04838791
122E2F1_21310950_ChIP-Seq_MCF-7_Human1.04808854
123SOX2_19829295_ChIP-Seq_ESCs_Human1.02465535
124NANOG_19829295_ChIP-Seq_ESCs_Human1.02465535
125* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02150710
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.00505599
127KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99277645
128TP63_19390658_ChIP-ChIP_HaCaT_Human0.98718509
129NCOR_22424771_ChIP-Seq_293T_Human0.98647302
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98380516
131OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97422641
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.97185730
133* REST_18959480_ChIP-ChIP_MESCs_Mouse0.94982911
134VDR_21846776_ChIP-Seq_THP-1_Human0.94954526
135FLI1_27457419_Chip-Seq_LIVER_Mouse0.94459771
136RARB_27405468_Chip-Seq_BRAIN_Mouse0.94274125
137* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.93916014
138TCF4_22108803_ChIP-Seq_LS180_Human0.93651568
139CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93304028
140CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93199270
141SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93170783
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92961287
143* KDM2B_26808549_Chip-Seq_JURKAT_Human0.92849613
144VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92301333
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.91485317
146CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90599077
147SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90393324
148CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88065309
149RXR_22108803_ChIP-Seq_LS180_Human0.86785624
150TET1_21490601_ChIP-Seq_MESCs_Mouse0.85856796
151* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85407557
152KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85312003
153WDR5_24793694_ChIP-Seq_LNCAP_Human0.85284952
154WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84813296
155* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81882701
156MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81700559
157ZFP281_27345836_Chip-Seq_ESCs_Mouse0.79019172
158TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78174393
159SA1_27219007_Chip-Seq_ERYTHROID_Human0.77463806
160DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77137113
161MYCN_18555785_ChIP-Seq_MESCs_Mouse0.75715058
162CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.75463565

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.01933847
2MP0003646_muscle_fatigue4.90740693
3MP0002102_abnormal_ear_morphology4.57740909
4MP0006292_abnormal_olfactory_placode3.51017960
5MP0005423_abnormal_somatic_nervous3.25120112
6MP0005451_abnormal_body_composition2.99444377
7MP0003122_maternal_imprinting2.93386720
8MP0003718_maternal_effect2.78011312
9MP0004133_heterotaxia2.53971145
10MP0003693_abnormal_embryo_hatching2.52629211
11MP0002249_abnormal_larynx_morphology2.46448992
12MP0004859_abnormal_synaptic_plasticity2.33787825
13MP0001346_abnormal_lacrimal_gland2.25155574
14MP0002638_abnormal_pupillary_reflex2.23447775
15MP0003123_paternal_imprinting2.22796024
16MP0003315_abnormal_perineum_morphology2.21849813
17MP0002837_dystrophic_cardiac_calcinosis2.21261708
18MP0005379_endocrine/exocrine_gland_phen2.15506140
19MP0009780_abnormal_chondrocyte_physiolo2.13615354
20MP0004270_analgesia2.09083229
21MP0006276_abnormal_autonomic_nervous2.07568261
22MP0000566_synostosis2.02787870
23MP0003077_abnormal_cell_cycle1.90826533
24MP0005645_abnormal_hypothalamus_physiol1.90723690
25MP0003111_abnormal_nucleus_morphology1.86100854
26MP0000579_abnormal_nail_morphology1.84192235
27MP0005551_abnormal_eye_electrophysiolog1.82477134
28MP0002735_abnormal_chemical_nociception1.82016141
29MP0010094_abnormal_chromosome_stability1.81894345
30MP0010030_abnormal_orbit_morphology1.78069044
31MP0000569_abnormal_digit_pigmentation1.76484542
32MP0004957_abnormal_blastocyst_morpholog1.71127974
33MP0003787_abnormal_imprinting1.70364348
34MP0008877_abnormal_DNA_methylation1.70273565
35MP0000778_abnormal_nervous_system1.70250800
36MP0001984_abnormal_olfaction1.67699941
37MP0005646_abnormal_pituitary_gland1.65583057
38MP0008789_abnormal_olfactory_epithelium1.64877742
39MP0005253_abnormal_eye_physiology1.62879499
40MP0005394_taste/olfaction_phenotype1.58246759
41MP0005499_abnormal_olfactory_system1.58246759
42MP0001119_abnormal_female_reproductive1.55771927
43MP0002822_catalepsy1.54770259
44MP0002210_abnormal_sex_determination1.54361121
45MP0000631_abnormal_neuroendocrine_gland1.50525225
46MP0002909_abnormal_adrenal_gland1.44647690
47MP0003699_abnormal_female_reproductive1.43213247
48MP0004858_abnormal_nervous_system1.40889570
49MP0003937_abnormal_limbs/digits/tail_de1.37650413
50MP0010386_abnormal_urinary_bladder1.36181638
51MP0000653_abnormal_sex_gland1.34777319
52MP0003635_abnormal_synaptic_transmissio1.34206665
53MP0003890_abnormal_embryonic-extraembry1.33269098
54MP0001502_abnormal_circadian_rhythm1.33203696
55MP0005408_hypopigmentation1.32982660
56MP0002734_abnormal_mechanical_nocicepti1.32519671
57MP0002557_abnormal_social/conspecific_i1.32090263
58MP0001929_abnormal_gametogenesis1.31250288
59MP0001529_abnormal_vocalization1.31209873
60MP0001486_abnormal_startle_reflex1.30719319
61MP0003195_calcinosis1.30505124
62MP0003880_abnormal_central_pattern1.30154739
63MP0005248_abnormal_Harderian_gland1.29782720
64MP0000678_abnormal_parathyroid_gland1.29758996
65MP0002090_abnormal_vision1.26599981
66MP0003011_delayed_dark_adaptation1.26130851
67MP0009046_muscle_twitch1.25672169
68MP0002184_abnormal_innervation1.24871282
69MP0002063_abnormal_learning/memory/cond1.24348868
70MP0002272_abnormal_nervous_system1.24221126
71MP0005386_behavior/neurological_phenoty1.23571396
72MP0004924_abnormal_behavior1.23571396
73MP0002067_abnormal_sensory_capabilities1.22456053
74MP0004142_abnormal_muscle_tone1.21991694
75MP0002234_abnormal_pharynx_morphology1.21534815
76MP0001485_abnormal_pinna_reflex1.17667649
77MP0005187_abnormal_penis_morphology1.17123705
78MP0006072_abnormal_retinal_apoptosis1.15981715
79MP0002282_abnormal_trachea_morphology1.15482835
80MP0004185_abnormal_adipocyte_glucose1.14686671
81MP0000049_abnormal_middle_ear1.14032573
82MP0004885_abnormal_endolymph1.13242852
83MP0003755_abnormal_palate_morphology1.12555397
84MP0009379_abnormal_foot_pigmentation1.10795316
85MP0003861_abnormal_nervous_system1.10331402
86MP0002938_white_spotting1.08753848
87MP0002876_abnormal_thyroid_physiology1.08115674
88MP0000955_abnormal_spinal_cord1.04818212
89MP0001905_abnormal_dopamine_level1.04260455
90MP0000639_abnormal_adrenal_gland1.02293652
91MP0002064_seizures1.01595982
92MP0000462_abnormal_digestive_system1.01117380
93MP0005257_abnormal_intraocular_pressure1.00684197
94MP0005195_abnormal_posterior_eye1.00072385
95MP0000026_abnormal_inner_ear0.99319218
96MP0001919_abnormal_reproductive_system0.98996909
97MP0001145_abnormal_male_reproductive0.98056766
98MP0001944_abnormal_pancreas_morphology0.97875490
99MP0001986_abnormal_taste_sensitivity0.97624685
100MP0003121_genomic_imprinting0.96350287
101MP0009250_abnormal_appendicular_skeleto0.95871353
102MP0002069_abnormal_eating/drinking_beha0.95668879
103MP0005377_hearing/vestibular/ear_phenot0.95345146
104MP0003878_abnormal_ear_physiology0.95345146
105MP0005395_other_phenotype0.94763920
106MP0002882_abnormal_neuron_morphology0.93729520
107MP0002116_abnormal_craniofacial_bone0.92579141
108MP0003137_abnormal_impulse_conducting0.91675191
109MP0005391_vision/eye_phenotype0.91495100
110MP0000613_abnormal_salivary_gland0.89944379
111MP0001293_anophthalmia0.89434100
112MP0002177_abnormal_outer_ear0.89277199
113MP0003938_abnormal_ear_development0.88809384
114MP0002163_abnormal_gland_morphology0.88470190
115MP0004145_abnormal_muscle_electrophysio0.87805218
116MP0002085_abnormal_embryonic_tissue0.87350741
117MP0003119_abnormal_digestive_system0.87077412
118MP0002752_abnormal_somatic_nervous0.86250176
119MP0002152_abnormal_brain_morphology0.86191584
120MP0001970_abnormal_pain_threshold0.85960272
121MP0002928_abnormal_bile_duct0.85676258
122MP0002161_abnormal_fertility/fecundity0.85250800
123MP0001963_abnormal_hearing_physiology0.84852242
124MP0002572_abnormal_emotion/affect_behav0.83769719
125MP0008775_abnormal_heart_ventricle0.83304645
126MP0004742_abnormal_vestibular_system0.82408416
127MP0002733_abnormal_thermal_nociception0.82357573
128MP0004085_abnormal_heartbeat0.80478265
129MP0002693_abnormal_pancreas_physiology0.79334064
130MP0005197_abnormal_uvea_morphology0.79170100
131MP0003136_yellow_coat_color0.78307661
132MP0002229_neurodegeneration0.75936623
133MP0002736_abnormal_nociception_after0.75279868
134MP0004811_abnormal_neuron_physiology0.74184483
135MP0000350_abnormal_cell_proliferation0.73343847
136MP0002095_abnormal_skin_pigmentation0.73215722
137MP0001299_abnormal_eye_distance/0.73059731
138MP0008932_abnormal_embryonic_tissue0.72083710
139MP0001324_abnormal_eye_pigmentation0.70710366
140MP0001968_abnormal_touch/_nociception0.70547540
141MP0003698_abnormal_male_reproductive0.70246188
142MP0000762_abnormal_tongue_morphology0.69444995
143MP0003329_amyloid_beta_deposits0.69438890
144MP0002332_abnormal_exercise_endurance0.69093357
145MP0002233_abnormal_nose_morphology0.68833126
146MP0004510_myositis0.68479414
147MP0000467_abnormal_esophagus_morphology0.67878170
148MP0000427_abnormal_hair_cycle0.67723963
149MP0009745_abnormal_behavioral_response0.67675111
150MP0002751_abnormal_autonomic_nervous0.67260159
151MP0001851_eye_inflammation0.66738606

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)4.68779404
2Abnormal ciliary motility (HP:0012262)4.44628377
3Hip dysplasia (HP:0001385)4.22264591
4Secondary amenorrhea (HP:0000869)4.05598699
5Abnormal respiratory motile cilium physiology (HP:0012261)3.99828761
6Fibular aplasia (HP:0002990)3.90225761
7Focal motor seizures (HP:0011153)3.59291929
8Patellar aplasia (HP:0006443)3.46221814
9Mesangial abnormality (HP:0001966)3.39099191
10Pancreatic fibrosis (HP:0100732)3.35843972
11True hermaphroditism (HP:0010459)3.30329623
12Myokymia (HP:0002411)3.28974018
13Abnormality of the septum pellucidum (HP:0007375)3.23859952
14Disproportionate short-trunk short stature (HP:0003521)3.21418242
15Aplasia/Hypoplasia of the patella (HP:0006498)3.19664154
16Molar tooth sign on MRI (HP:0002419)3.17915172
17Abnormality of midbrain morphology (HP:0002418)3.17915172
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08594091
19Pancreatic cysts (HP:0001737)3.03358650
20Birth length less than 3rd percentile (HP:0003561)3.02138439
21Absent septum pellucidum (HP:0001331)3.01758170
22Nephronophthisis (HP:0000090)3.00341956
23Hip contracture (HP:0003273)2.96295984
24Chromsome breakage (HP:0040012)2.93745900
25Septo-optic dysplasia (HP:0100842)2.93672353
26Breast hypoplasia (HP:0003187)2.89199541
27Carpal bone hypoplasia (HP:0001498)2.83788350
28Abnormality of the renal medulla (HP:0100957)2.82832076
29Medial flaring of the eyebrow (HP:0010747)2.81737191
30Flat capital femoral epiphysis (HP:0003370)2.80092798
31Broad-based gait (HP:0002136)2.78844971
32Adrenal hypoplasia (HP:0000835)2.74940001
33Cortical dysplasia (HP:0002539)2.73380232
34Shawl scrotum (HP:0000049)2.71969936
35Gait imbalance (HP:0002141)2.66682570
36Aplasia involving bones of the upper limbs (HP:0009823)2.66359836
37Aplasia of the phalanges of the hand (HP:0009802)2.66359836
38Aplasia involving bones of the extremities (HP:0009825)2.66359836
39Deep palmar crease (HP:0006191)2.62701170
40Hemiparesis (HP:0001269)2.61954681
41Intestinal atresia (HP:0011100)2.61903993
42Hepatoblastoma (HP:0002884)2.60043777
43Hyperinsulinemic hypoglycemia (HP:0000825)2.53290578
44Hypoglycemic coma (HP:0001325)2.51703151
45Supernumerary spleens (HP:0009799)2.51166868
46Morphological abnormality of the middle ear (HP:0008609)2.49745745
47Hypoglycemic seizures (HP:0002173)2.49005662
48Congenital primary aphakia (HP:0007707)2.46632787
49Methylmalonic acidemia (HP:0002912)2.46254492
50Facial hemangioma (HP:0000329)2.45093726
51Abnormality of the labia minora (HP:0012880)2.44989446
52Hyperacusis (HP:0010780)2.44542072
53Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.44030171
54Hand muscle atrophy (HP:0009130)2.42972464
55Visual hallucinations (HP:0002367)2.41665348
56Ketoacidosis (HP:0001993)2.38987226
57Stridor (HP:0010307)2.37150620
58Pulmonary fibrosis (HP:0002206)2.37083619
59Optic nerve hypoplasia (HP:0000609)2.34219425
60Aplasia/Hypoplasia of the breasts (HP:0010311)2.34065334
61Neoplasm of the adrenal cortex (HP:0100641)2.33989653
62Abnormality of the renal cortex (HP:0011035)2.33763534
63Anencephaly (HP:0002323)2.32835017
64Breast aplasia (HP:0100783)2.32618103
65Nephrogenic diabetes insipidus (HP:0009806)2.32556790
66Short tibia (HP:0005736)2.32197650
67Hypothermia (HP:0002045)2.31890922
68Hyperglycinemia (HP:0002154)2.31711757
69Chin dimple (HP:0010751)2.29368243
70Agitation (HP:0000713)2.28646568
71Abnormality of the middle phalanges of the toes (HP:0010183)2.27439278
72Chronic hepatic failure (HP:0100626)2.26504251
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.26441284
74Primary amenorrhea (HP:0000786)2.26040640
75Aplasia/Hypoplasia of the sternum (HP:0006714)2.21721453
76Postaxial hand polydactyly (HP:0001162)2.19821010
77Meckel diverticulum (HP:0002245)2.19806361
78Postaxial foot polydactyly (HP:0001830)2.19487300
79Congenital malformation of the right heart (HP:0011723)2.18747690
80Double outlet right ventricle (HP:0001719)2.18747690
81Barrel-shaped chest (HP:0001552)2.17073429
82Progressive macrocephaly (HP:0004481)2.16354066
83Atonic seizures (HP:0010819)2.16089613
84Polyphagia (HP:0002591)2.15249839
85Median cleft lip (HP:0000161)2.14193374
86Rib fusion (HP:0000902)2.13695069
87Rapidly progressive (HP:0003678)2.12928754
88Striae distensae (HP:0001065)2.12642621
89Obstructive sleep apnea (HP:0002870)2.12550501
90Acute necrotizing encephalopathy (HP:0006965)2.11397813
91Absence seizures (HP:0002121)2.11290086
92Absent hand (HP:0004050)2.08340728
93Aplasia/hypoplasia of the uterus (HP:0008684)2.07829260
94Cystic liver disease (HP:0006706)2.07268978
95Muscle fiber atrophy (HP:0100295)2.05343667
96Pendular nystagmus (HP:0012043)2.05326553
97Sleep apnea (HP:0010535)2.05081544
98Abnormality of the aortic arch (HP:0012303)2.04971654
99Aplastic anemia (HP:0001915)2.04479184
100Lissencephaly (HP:0001339)2.04276337
101Tubulointerstitial nephritis (HP:0001970)2.04216685
102Lip pit (HP:0100267)2.03808179
103Renal cortical cysts (HP:0000803)2.03298705
104Down-sloping shoulders (HP:0200021)2.03214920
105Abnormality of the ileum (HP:0001549)2.01787822
106Aplasia of the musculature (HP:0100854)2.01701866
107Cerebral palsy (HP:0100021)2.00604388
108Muscle fiber splitting (HP:0003555)2.00140313
109Volvulus (HP:0002580)1.99829977
110Aplasia/Hypoplasia of the tongue (HP:0010295)1.98718059
111Abnormality of the metopic suture (HP:0005556)1.98465220
112Maternal diabetes (HP:0009800)1.98290285
113Ketosis (HP:0001946)1.98203958
114Abnormality of chromosome segregation (HP:0002916)1.98123391
115Congenital sensorineural hearing impairment (HP:0008527)1.97787525
116Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97553660
117Posterior embryotoxon (HP:0000627)1.96688967
118Limited hip movement (HP:0008800)1.96636272
119Abnormality of the fingertips (HP:0001211)1.95204867
120Premature ovarian failure (HP:0008209)1.95138489
121Bony spicule pigmentary retinopathy (HP:0007737)1.95051827
122Limb-girdle muscle atrophy (HP:0003797)1.94136379
123Overlapping toe (HP:0001845)1.93509860
124Congenital hepatic fibrosis (HP:0002612)1.93404579
125Apathy (HP:0000741)1.93229682
126Anterior segment dysgenesis (HP:0007700)1.93190832
127Amblyopia (HP:0000646)1.92679702
128Oligodactyly (hands) (HP:0001180)1.92398385
129Abnormality of the calf musculature (HP:0001430)1.91965607
130Nonprogressive disorder (HP:0003680)1.90815123
131Abnormality of the fovea (HP:0000493)1.90731854
132Occipital encephalocele (HP:0002085)1.90631758
133Hypsarrhythmia (HP:0002521)1.90416536
134Absent radius (HP:0003974)1.90225352
135Genital tract atresia (HP:0001827)1.89947562
136EEG with generalized epileptiform discharges (HP:0011198)1.89540103
137Midline defect of the nose (HP:0004122)1.89357548
138Aplasia involving forearm bones (HP:0009822)1.89107483
139Absent forearm bone (HP:0003953)1.89107483
140Abnormality of endocrine pancreas physiology (HP:0012093)1.88704344
141Abnormality of the pancreatic islet cells (HP:0006476)1.88704344
142Diminished motivation (HP:0000745)1.88226884
143Sclerocornea (HP:0000647)1.87268491
144Diaphragmatic weakness (HP:0009113)1.87219094
145Aplasia/Hypoplasia affecting the retina (HP:0008061)1.87079036
146Methylmalonic aciduria (HP:0012120)1.86379608
147Papilledema (HP:0001085)1.86210654
148Limb dystonia (HP:0002451)1.85177607
149Insidious onset (HP:0003587)1.84921035
150Termporal pattern (HP:0011008)1.84921035
151Pachygyria (HP:0001302)1.84559881
152Type II lissencephaly (HP:0007260)1.83914532
153Abnormal mitochondria in muscle tissue (HP:0008316)1.83447864
154Renal dysplasia (HP:0000110)1.83347371
155Abnormality of the vocal cords (HP:0008777)1.83040246
156Infertility (HP:0000789)1.82929052
157Vaginal atresia (HP:0000148)1.82067802
158Epileptiform EEG discharges (HP:0011182)1.81751407
159Fetal akinesia sequence (HP:0001989)1.81563294
160Preaxial hand polydactyly (HP:0001177)1.81225215
161Difficulty running (HP:0009046)1.80882713
162Abnormality of the line of Schwalbe (HP:0008048)1.79472458
163Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.79441477
164Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78920057
165Hyperglycemia (HP:0003074)1.78770045
166Rimmed vacuoles (HP:0003805)1.78556172
167Spinal muscular atrophy (HP:0007269)1.77909864
168Specific learning disability (HP:0001328)1.77196412
169Arterial tortuosity (HP:0005116)1.77044200
170Hypergonadotropic hypogonadism (HP:0000815)1.76558094
171Acute encephalopathy (HP:0006846)1.76268065
172Optic disc pallor (HP:0000543)1.76017792
173Growth hormone deficiency (HP:0000824)1.75909133
174Impulsivity (HP:0100710)1.75511956
175Aplasia/Hypoplasia of the fovea (HP:0008060)1.73755660
176Hypoplasia of the fovea (HP:0007750)1.73755660
177Achilles tendon contracture (HP:0001771)1.69027012
178Megalocornea (HP:0000485)1.68933392
179Insomnia (HP:0100785)1.67918476
180Generalized myoclonic seizures (HP:0002123)1.66607053
181Capillary hemangiomas (HP:0005306)1.66523897
182Large eyes (HP:0001090)1.63733082
183Horseshoe kidney (HP:0000085)1.62967713
184Abnormality of the heme biosynthetic pathway (HP:0010472)1.62389728
185Erectile abnormalities (HP:0100639)1.62235954
186Anosmia (HP:0000458)1.61372719
187Abnormality of the proximal phalanges of the hand (HP:0009834)1.61074564
188Oligomenorrhea (HP:0000876)1.59830233
189Abnormality of the diencephalon (HP:0010662)1.59635204
190Milia (HP:0001056)1.59352028
191Focal dystonia (HP:0004373)1.59176425
192Flat occiput (HP:0005469)1.58783345
193Sporadic (HP:0003745)1.57621304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.49364932
2MAP3K94.30292099
3FRK4.16907126
4MAP4K23.44230654
5MAP3K63.34135451
6LATS23.09313535
7KSR23.04143928
8TNIK2.86091871
9PRKD32.80362192
10MAP3K102.75844337
11WNK32.50069251
12PLK42.44980590
13LATS12.19954391
14ERBB42.18643078
15CDK191.90608123
16PHKG21.88425657
17PHKG11.88425657
18CDC71.79861238
19STK38L1.74014052
20PAK31.72675733
21ADRBK21.70341693
22FGFR21.69266367
23MAP2K71.68517682
24EEF2K1.67223732
25CDK81.66759039
26BUB11.65212760
27TAOK11.65086702
28MOS1.64534202
29BMPR1B1.61250235
30TTK1.57234334
31KSR11.57161672
32MAP3K41.55747507
33DYRK21.55282560
34MUSK1.54488897
35RAF11.53968621
36BRAF1.53879521
37TRIM281.53262675
38ARAF1.49671798
39MAP3K131.49414262
40BCKDK1.49313909
41PINK11.41876790
42EPHA31.38337911
43PRKD21.36240912
44GRK11.33785485
45OBSCN1.33652608
46MAP3K71.32334393
47MAPK131.31919705
48TAOK31.29709161
49INSRR1.23497667
50BMPR21.22850379
51BCR1.22340936
52MAPKAPK31.19997096
53FER1.19649120
54STK161.16660385
55ILK1.15668402
56NUAK11.13095097
57UHMK11.10259163
58TAF11.08640162
59OXSR11.08602617
60STK391.08010617
61ERBB31.07904789
62WNK41.06362674
63MAP2K41.04485881
64NLK1.03781770
65ABL21.03608191
66CHEK21.03408484
67PAK61.02905086
68EPHA40.94612816
69CDK90.93944839
70SRPK10.93071071
71MARK10.91620028
72PRKCG0.91023034
73PRKCE0.87423276
74NEK20.87137576
75MAP3K20.81572464
76PLK10.79850834
77TYRO30.75438957
78ZAK0.75105451
79PKN10.72816734
80NTRK20.68381912
81NTRK30.65935694
82PNCK0.65592330
83AURKA0.63335155
84STK380.63129822
85DMPK0.61457322
86SIK20.59698386
87STK30.59229176
88RET0.58719667
89DYRK1B0.58606898
90MKNK20.56916960
91MELK0.55137660
92PRKACA0.54788217
93CAMK10.53838569
94HIPK20.53520816
95PRKAA20.53013810
96MAP3K10.52607249
97RPS6KA40.51635263
98PLK20.49190921
99VRK10.47608722
100CSNK1G20.47483423
101MINK10.46770287
102CSNK1G30.46502613
103LIMK10.46500405
104AURKB0.46310499
105DAPK30.45666482
106NTRK10.45566946
107DAPK20.45349064
108CDK11A0.43419097
109PRKG10.43304822
110PIK3CG0.43035369
111RPS6KA10.42314490
112TYK20.41761659
113CSNK1E0.40115102
114MAPK110.39183429
115CDK150.39014366
116FGR0.38945710
117PLK30.38576049
118MKNK10.38259787
119CSNK1D0.38138122
120MARK20.37908581
121CDK180.37905547
122CASK0.37537049
123CAMK40.37488506
124CAMK2A0.37090741
125STK110.37081776
126CSNK1A10.36782374
127MAP3K80.36770006
128CSNK1G10.36174048
129SGK2230.36082477
130SGK4940.36082477
131SGK20.35658025
132ERBB20.35654211
133PASK0.34765859
134SGK10.34102399
135ROCK20.34004127
136DYRK1A0.33679818
137RPS6KB20.33326699
138CAMK2D0.32176502
139ACVR1B0.31550793
140PRKCI0.29877303
141MAP3K120.29542501
142CDK70.29255874
143GSK3B0.28793547
144MAPKAPK50.28724121
145CDK140.28616139
146PRKCA0.28231054
147EPHB20.28229236
148FES0.28163883
149CCNB10.27936491
150MAPK150.27321603
151ADRBK10.27222161
152PRKCH0.26657896
153PRKAA10.26490615
154GRK50.26249631
155PRKACG0.25774038
156DYRK30.23471603
157CSNK1A1L0.23222090
158CDK50.22450621
159MAP2K10.22255142
160ATM0.20948426

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.69630969
2Cell cycle_Homo sapiens_hsa041103.04842326
3RNA degradation_Homo sapiens_hsa030182.87202939
4Oocyte meiosis_Homo sapiens_hsa041142.79445660
5Ovarian steroidogenesis_Homo sapiens_hsa049132.51057666
6Butanoate metabolism_Homo sapiens_hsa006502.50446691
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.37491058
8GnRH signaling pathway_Homo sapiens_hsa049122.31266025
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28692500
10Protein export_Homo sapiens_hsa030602.24801336
11Oxidative phosphorylation_Homo sapiens_hsa001902.20921784
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06894409
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03407177
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02801646
15Circadian rhythm_Homo sapiens_hsa047102.02614940
16Cardiac muscle contraction_Homo sapiens_hsa042602.00708366
17Propanoate metabolism_Homo sapiens_hsa006401.91217713
18Regulation of autophagy_Homo sapiens_hsa041401.89923026
19Insulin secretion_Homo sapiens_hsa049111.82954910
20Long-term depression_Homo sapiens_hsa047301.77178725
21Colorectal cancer_Homo sapiens_hsa052101.76383292
22Basal transcription factors_Homo sapiens_hsa030221.71290021
23Long-term potentiation_Homo sapiens_hsa047201.65019076
24Parkinsons disease_Homo sapiens_hsa050121.64540669
25Pancreatic cancer_Homo sapiens_hsa052121.63576385
26Glutamatergic synapse_Homo sapiens_hsa047241.52868110
27Spliceosome_Homo sapiens_hsa030401.52240938
28Ribosome_Homo sapiens_hsa030101.52164001
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51828784
30Olfactory transduction_Homo sapiens_hsa047401.50205654
31Fatty acid elongation_Homo sapiens_hsa000621.48331183
32Tryptophan metabolism_Homo sapiens_hsa003801.45064499
33Dopaminergic synapse_Homo sapiens_hsa047281.43590071
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41432409
35RNA transport_Homo sapiens_hsa030131.40304263
36VEGF signaling pathway_Homo sapiens_hsa043701.37592852
37Thyroid cancer_Homo sapiens_hsa052161.35736039
38mRNA surveillance pathway_Homo sapiens_hsa030151.35303763
39Hippo signaling pathway_Homo sapiens_hsa043901.35216248
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34292915
41Choline metabolism in cancer_Homo sapiens_hsa052311.32389366
42TGF-beta signaling pathway_Homo sapiens_hsa043501.32228783
43Homologous recombination_Homo sapiens_hsa034401.32102446
44DNA replication_Homo sapiens_hsa030301.31892765
45Melanogenesis_Homo sapiens_hsa049161.31397021
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29883488
47Hedgehog signaling pathway_Homo sapiens_hsa043401.29199304
48Bladder cancer_Homo sapiens_hsa052191.27826255
49Glioma_Homo sapiens_hsa052141.27572239
50mTOR signaling pathway_Homo sapiens_hsa041501.24129869
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23096485
52Serotonergic synapse_Homo sapiens_hsa047261.22985262
53Steroid biosynthesis_Homo sapiens_hsa001001.22917799
54Wnt signaling pathway_Homo sapiens_hsa043101.20596045
55Nicotine addiction_Homo sapiens_hsa050331.20410339
56Peroxisome_Homo sapiens_hsa041461.20313412
57Fanconi anemia pathway_Homo sapiens_hsa034601.20188199
58Prolactin signaling pathway_Homo sapiens_hsa049171.20138999
59Cholinergic synapse_Homo sapiens_hsa047251.20057603
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20020579
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19779842
62Taste transduction_Homo sapiens_hsa047421.17996214
63Vitamin B6 metabolism_Homo sapiens_hsa007501.16071403
64Gap junction_Homo sapiens_hsa045401.14997801
65Base excision repair_Homo sapiens_hsa034101.13224802
66Collecting duct acid secretion_Homo sapiens_hsa049661.12833440
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12500004
68Alzheimers disease_Homo sapiens_hsa050101.11787542
69Amphetamine addiction_Homo sapiens_hsa050311.10883087
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06953242
71Circadian entrainment_Homo sapiens_hsa047131.05885330
72Ether lipid metabolism_Homo sapiens_hsa005651.05871184
73Folate biosynthesis_Homo sapiens_hsa007901.05227700
74Linoleic acid metabolism_Homo sapiens_hsa005911.04906815
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04096412
76Estrogen signaling pathway_Homo sapiens_hsa049151.02802281
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02633344
78Oxytocin signaling pathway_Homo sapiens_hsa049211.02623095
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02321898
80MicroRNAs in cancer_Homo sapiens_hsa052061.01399754
81Arginine and proline metabolism_Homo sapiens_hsa003301.01145786
82Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00601112
83Non-small cell lung cancer_Homo sapiens_hsa052231.00502978
84Fatty acid degradation_Homo sapiens_hsa000711.00473837
85Phospholipase D signaling pathway_Homo sapiens_hsa040721.00341230
86RNA polymerase_Homo sapiens_hsa030200.99038054
87Endometrial cancer_Homo sapiens_hsa052130.98148404
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97352645
89Notch signaling pathway_Homo sapiens_hsa043300.97153817
90Fatty acid metabolism_Homo sapiens_hsa012120.95359293
91Caffeine metabolism_Homo sapiens_hsa002320.93834568
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93019158
93Basal cell carcinoma_Homo sapiens_hsa052170.89149602
94Nitrogen metabolism_Homo sapiens_hsa009100.87163482
95Renal cell carcinoma_Homo sapiens_hsa052110.86157881
96Ras signaling pathway_Homo sapiens_hsa040140.85712454
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84345590
98beta-Alanine metabolism_Homo sapiens_hsa004100.83850676
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82280501
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.81529970
101Synaptic vesicle cycle_Homo sapiens_hsa047210.81257206
102ABC transporters_Homo sapiens_hsa020100.81228205
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80827431
104ErbB signaling pathway_Homo sapiens_hsa040120.80756552
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80388059
106MAPK signaling pathway_Homo sapiens_hsa040100.78593198
107Sulfur metabolism_Homo sapiens_hsa009200.78147864
108Axon guidance_Homo sapiens_hsa043600.76645056
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76318467
110Melanoma_Homo sapiens_hsa052180.75823879
111Salivary secretion_Homo sapiens_hsa049700.75462865
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75421920
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75151954
114Mineral absorption_Homo sapiens_hsa049780.74648297
115cAMP signaling pathway_Homo sapiens_hsa040240.72830039
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72741759
117Mismatch repair_Homo sapiens_hsa034300.72712589
118Cocaine addiction_Homo sapiens_hsa050300.72255471
119Dorso-ventral axis formation_Homo sapiens_hsa043200.71721524
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.71691662
121Alcoholism_Homo sapiens_hsa050340.71633059
122Retinol metabolism_Homo sapiens_hsa008300.71206368
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71157028
124Chronic myeloid leukemia_Homo sapiens_hsa052200.70540289
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70463668
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67828719
127Chemical carcinogenesis_Homo sapiens_hsa052040.67718261
128Metabolic pathways_Homo sapiens_hsa011000.66703261
129Phototransduction_Homo sapiens_hsa047440.66545395
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64891204
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63000810
132Huntingtons disease_Homo sapiens_hsa050160.62609503
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.61203751
134Type II diabetes mellitus_Homo sapiens_hsa049300.60924781
135Pyrimidine metabolism_Homo sapiens_hsa002400.60644579
136Gastric acid secretion_Homo sapiens_hsa049710.59906465
137Rap1 signaling pathway_Homo sapiens_hsa040150.57920448
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56894647
139Renin secretion_Homo sapiens_hsa049240.56510351
140Morphine addiction_Homo sapiens_hsa050320.56397902
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56229310
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55798578
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.55603520
144Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51620691
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51322866
146HTLV-I infection_Homo sapiens_hsa051660.51245311
147Glucagon signaling pathway_Homo sapiens_hsa049220.50263658
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.50096208
149GABAergic synapse_Homo sapiens_hsa047270.49519030
150Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49449834
151Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47661753
152p53 signaling pathway_Homo sapiens_hsa041150.46933473
153AMPK signaling pathway_Homo sapiens_hsa041520.46553056
154Dilated cardiomyopathy_Homo sapiens_hsa054140.46310178
155Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45438743
156Calcium signaling pathway_Homo sapiens_hsa040200.45019890
157Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38968450
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.37486661
159Purine metabolism_Homo sapiens_hsa002300.36561088
160Lysine degradation_Homo sapiens_hsa003100.36425260

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