LMO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.48898298
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.98126542
3viral transcription (GO:0019083)5.96208099
4translational termination (GO:0006415)5.71849539
5response to peptidoglycan (GO:0032494)5.65728685
6definitive hemopoiesis (GO:0060216)5.63521969
7DNA deamination (GO:0045006)5.39327529
8neutrophil activation involved in immune response (GO:0002283)5.24018441
9* negative regulation of erythrocyte differentiation (GO:0045647)5.18426316
10platelet dense granule organization (GO:0060155)5.08573170
11antigen processing and presentation via MHC class Ib (GO:0002475)5.04556315
12translational elongation (GO:0006414)4.97611044
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.89210718
14cotranslational protein targeting to membrane (GO:0006613)4.77202463
15protein targeting to ER (GO:0045047)4.74828021
16positive regulation by symbiont of host defense response (GO:0052509)4.72101139
17modulation by symbiont of host defense response (GO:0052031)4.72101139
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.72101139
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.72101139
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.72101139
21modulation by symbiont of host immune response (GO:0052553)4.72101139
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.71704148
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.71704148
24ribosomal small subunit biogenesis (GO:0042274)4.62896466
25maturation of SSU-rRNA (GO:0030490)4.61721384
26establishment of protein localization to endoplasmic reticulum (GO:0072599)4.52854756
27protein localization to endoplasmic reticulum (GO:0070972)4.51619912
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.43647216
29positive regulation of B cell differentiation (GO:0045579)4.43077105
30viral life cycle (GO:0019058)4.40834938
31megakaryocyte development (GO:0035855)4.35012429
32response to interferon-beta (GO:0035456)4.24641364
33cellular protein complex disassembly (GO:0043624)4.19166235
34lymphoid progenitor cell differentiation (GO:0002320)4.18370420
35regulation of mast cell degranulation (GO:0043304)4.17998534
36cellular extravasation (GO:0045123)4.12883075
37negative regulation of interleukin-12 production (GO:0032695)4.11878019
38endosome to pigment granule transport (GO:0043485)4.11655094
39endosome to melanosome transport (GO:0035646)4.11655094
40microglial cell activation (GO:0001774)4.08693924
41response to muramyl dipeptide (GO:0032495)4.05533491
42regulation of gamma-delta T cell activation (GO:0046643)4.04917210
43detection of other organism (GO:0098543)4.04745411
44translational initiation (GO:0006413)3.98557083
45antigen processing and presentation of endogenous antigen (GO:0019883)3.95128032
46regulation of B cell receptor signaling pathway (GO:0050855)3.94915994
47macrophage activation involved in immune response (GO:0002281)3.93342616
48telomere maintenance via semi-conservative replication (GO:0032201)3.89558537
49regulation of mast cell activation involved in immune response (GO:0033006)3.85841890
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.85759024
51negative regulation of cell killing (GO:0031342)3.85759024
52detection of bacterium (GO:0016045)3.81316443
53regulation of myeloid leukocyte mediated immunity (GO:0002886)3.79116027
54protein complex disassembly (GO:0043241)3.76625331
55deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.74769244
56response to interferon-alpha (GO:0035455)3.71625113
57B cell receptor signaling pathway (GO:0050853)3.70168714
58positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.68897984
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.67075087
60response to host immune response (GO:0052572)3.67075087
61regulation of leukocyte degranulation (GO:0043300)3.66162592
62positive regulation of mast cell activation (GO:0033005)3.64687731
63mature B cell differentiation involved in immune response (GO:0002313)3.61792969
64positive regulation of mast cell degranulation (GO:0043306)3.58993722
65positive regulation of mast cell activation involved in immune response (GO:0033008)3.58993722
66regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.56503346
67macrophage activation (GO:0042116)3.56149800
68positive regulation of gamma-delta T cell activation (GO:0046645)3.55917157
69germinal center formation (GO:0002467)3.51935110
70endothelium development (GO:0003158)3.51036379
71macromolecular complex disassembly (GO:0032984)3.50708980
72DNA strand elongation involved in DNA replication (GO:0006271)3.48641014
73secretory granule organization (GO:0033363)3.47251528
74myeloid cell activation involved in immune response (GO:0002275)3.47115877
75nuclear-transcribed mRNA catabolic process (GO:0000956)3.44257862
76neutrophil activation (GO:0042119)3.42745765
77regulation of mast cell activation (GO:0033003)3.41690175
78DNA strand elongation (GO:0022616)3.38233500
79detection of external biotic stimulus (GO:0098581)3.32541982
80mRNA catabolic process (GO:0006402)3.31510708
81positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.29600298
82regulation of B cell differentiation (GO:0045577)3.22781455
83granulocyte activation (GO:0036230)3.22539181
84telomere maintenance via recombination (GO:0000722)3.21875217
85response to host (GO:0075136)3.21759659
86response to host defenses (GO:0052200)3.21759659
87response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.21759659
88RNA catabolic process (GO:0006401)3.14642544
89histamine secretion (GO:0001821)3.13968112
90defense response to protozoan (GO:0042832)3.13661617
91protein targeting to membrane (GO:0006612)3.11461366
92lipopolysaccharide-mediated signaling pathway (GO:0031663)3.11377531
93regulation of regulated secretory pathway (GO:1903305)3.10136534
94pseudouridine synthesis (GO:0001522)3.10081607
95polyketide metabolic process (GO:0030638)3.09270390
96doxorubicin metabolic process (GO:0044598)3.09270390
97daunorubicin metabolic process (GO:0044597)3.09270390
98purine-containing compound salvage (GO:0043101)3.09104204
99ribosomal large subunit biogenesis (GO:0042273)3.08962333
100detection of molecule of bacterial origin (GO:0032490)3.08259141
101negative regulation of bone mineralization (GO:0030502)3.07618282
102T cell homeostasis (GO:0043029)3.07478802
103leukocyte degranulation (GO:0043299)3.05689996
104erythrocyte maturation (GO:0043249)3.05435551
105neutrophil mediated immunity (GO:0002446)3.05285608
106positive regulation of granulocyte differentiation (GO:0030854)3.04817417
107negative regulation of T cell mediated immunity (GO:0002710)3.04638005
108regulation of interferon-beta biosynthetic process (GO:0045357)3.03602972
109detection of biotic stimulus (GO:0009595)3.01259050
110response to protozoan (GO:0001562)3.00679126
111negative regulation of lymphocyte mediated immunity (GO:0002707)2.97624336
112leukocyte aggregation (GO:0070486)2.96817330
113lymph node development (GO:0048535)2.96663157
114CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.95651194
115immunoglobulin mediated immune response (GO:0016064)2.94318364
116negative regulation of granulocyte differentiation (GO:0030853)2.94005522
117regulation of granulocyte differentiation (GO:0030852)2.93902503
118positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93326358
119positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.92448914
120ribonucleoprotein complex biogenesis (GO:0022613)2.89960952
121mature B cell differentiation (GO:0002335)2.89511817
122granulocyte differentiation (GO:0030851)2.89382187
123Peyers patch development (GO:0048541)2.87062260
124mucosal-associated lymphoid tissue development (GO:0048537)2.87062260
125DNA replication initiation (GO:0006270)2.82886125
126positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.82683158
127negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.82532687
128positive thymic T cell selection (GO:0045059)2.82261803
129mast cell activation (GO:0045576)2.81741275
130respiratory burst (GO:0045730)2.81036923
131negative regulation of leukocyte mediated immunity (GO:0002704)2.80054289
132interferon-gamma-mediated signaling pathway (GO:0060333)2.79903600
133regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78663446
134negative regulation of interleukin-6 production (GO:0032715)2.78261975
135mitotic recombination (GO:0006312)2.77447416
136respiratory chain complex IV assembly (GO:0008535)2.76993919
137* regulation of erythrocyte differentiation (GO:0045646)2.76478620
138necroptotic process (GO:0070266)2.76050917
139Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75814670
140positive regulation of interferon-alpha production (GO:0032727)2.75020267
141leukocyte migration involved in inflammatory response (GO:0002523)2.74938513
142translation (GO:0006412)2.74298665
143negative regulation of viral entry into host cell (GO:0046597)2.73987832
144regulation of interferon-alpha production (GO:0032647)2.73671543
145N-acetylneuraminate metabolic process (GO:0006054)2.73626664
146B cell mediated immunity (GO:0019724)2.72339379
147telomere maintenance via telomere lengthening (GO:0010833)2.72314900
148negative regulation of viral genome replication (GO:0045071)2.72258990
149negative regulation of cytokine production involved in immune response (GO:0002719)2.71489128
150positive regulation of tumor necrosis factor production (GO:0032760)2.70933673
151angiogenesis involved in wound healing (GO:0060055)2.70283856
152positive regulation of regulated secretory pathway (GO:1903307)2.68710932
153regulation of macrophage cytokine production (GO:0010935)2.68608068
154L-fucose catabolic process (GO:0042355)2.68398107
155fucose catabolic process (GO:0019317)2.68398107
156L-fucose metabolic process (GO:0042354)2.68398107
157negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66929886
158positive regulation of leukocyte degranulation (GO:0043302)2.65462591
159cellular response to type I interferon (GO:0071357)2.65191165
160type I interferon signaling pathway (GO:0060337)2.65191165
161tRNA methylation (GO:0030488)2.65058092
162regulation of interleukin-6 biosynthetic process (GO:0045408)2.64977748
163response to type I interferon (GO:0034340)2.64491619
164negative regulation of interleukin-17 production (GO:0032700)2.64066323
165iron-sulfur cluster assembly (GO:0016226)2.62884129
166metallo-sulfur cluster assembly (GO:0031163)2.62884129
167regulation of hypersensitivity (GO:0002883)2.62535320
168regulation of gamma-delta T cell differentiation (GO:0045586)2.60186033
169positive regulation of T cell mediated cytotoxicity (GO:0001916)2.59595398
170heparin biosynthetic process (GO:0030210)2.58643260
171heparin metabolic process (GO:0030202)2.58643260
172myeloid cell development (GO:0061515)2.57867258
173DNA unwinding involved in DNA replication (GO:0006268)2.56807466
174negative regulation of biomineral tissue development (GO:0070168)2.56587499
175mast cell activation involved in immune response (GO:0002279)2.56318372
176mast cell degranulation (GO:0043303)2.56318372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.59596897
2SCL_19346495_ChIP-Seq_HPC-7_Human4.34731829
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63007926
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06434222
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.05630768
6SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.03657245
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.98848660
8TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.92453634
9* IRF8_22096565_ChIP-ChIP_GC-B_Human2.90836969
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79111899
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.67460598
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.66506696
13FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.62986966
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.55161371
15GATA1_22025678_ChIP-Seq_K562_Human2.52875711
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50636942
17* VDR_21846776_ChIP-Seq_THP-1_Human2.43692870
18MYC_22102868_ChIP-Seq_BL_Human2.43127258
19* GATA1_19941826_ChIP-Seq_K562_Human2.35574562
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.32183661
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.25484350
22ERG_20887958_ChIP-Seq_HPC-7_Mouse2.21859343
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19981122
24SPI1_23547873_ChIP-Seq_NB4_Human2.17017465
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13422437
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09405297
27SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.08739768
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.01832089
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01516858
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95845334
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93146644
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91536488
33* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91403345
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.91181469
35VDR_23849224_ChIP-Seq_CD4+_Human1.90971675
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89972873
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.88703505
38* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87504854
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.85736086
40GATA1_22383799_ChIP-Seq_G1ME_Mouse1.81740667
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.81450471
42KDM2B_26808549_Chip-Seq_DND41_Human1.81151277
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.80295241
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78751927
45* VDR_24763502_ChIP-Seq_THP-1_Human1.78350714
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77850625
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77250267
48FOXP3_21729870_ChIP-Seq_TREG_Human1.75468828
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.74955220
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74330502
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74082779
52* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.71729670
53* VDR_24787735_ChIP-Seq_THP-1_Human1.68470671
54* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67792855
55* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.67606061
56CIITA_25753668_ChIP-Seq_RAJI_Human1.67175239
57* GATA2_19941826_ChIP-Seq_K562_Human1.66666632
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66289417
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64407145
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.64319084
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64298299
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63576352
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.62985828
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61307982
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61199259
66MAF_26560356_Chip-Seq_TH1_Human1.60373268
67XRN2_22483619_ChIP-Seq_HELA_Human1.58278030
68MYB_26560356_Chip-Seq_TH2_Human1.55917101
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53017907
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52064665
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.51444483
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47797176
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47491887
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46931811
75MYB_26560356_Chip-Seq_TH1_Human1.45800463
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45332785
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44332210
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43069662
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41969964
80* TCF7_22412390_ChIP-Seq_EML_Mouse1.41888236
81UTX_26944678_Chip-Seq_JUKART_Human1.41579098
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.40916711
83NCOR1_26117541_ChIP-Seq_K562_Human1.39091192
84GABP_19822575_ChIP-Seq_HepG2_Human1.38765914
85GATA3_27048872_Chip-Seq_THYMUS_Human1.36853389
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34469580
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32865737
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31087335
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.31066457
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30428448
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30311943
92LXR_22292898_ChIP-Seq_THP-1_Human1.29766005
93NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29012000
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28628384
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27493663
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25913094
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25510040
98TTF2_22483619_ChIP-Seq_HELA_Human1.24740338
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24543113
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23132003
101CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22452850
102PU_27001747_Chip-Seq_BMDM_Mouse1.22123433
103DCP1A_22483619_ChIP-Seq_HELA_Human1.21645176
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.21492543
105* IRF8_27001747_Chip-Seq_BMDM_Mouse1.20963300
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19361061
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19142542
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16961925
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.15652598
110BCL6_27268052_Chip-Seq_Bcells_Human1.15128060
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13785914
112E2F1_21310950_ChIP-Seq_MCF-7_Human1.13122936
113* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12569877
114* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11053685
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10495704
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08617871
117SPI1_23127762_ChIP-Seq_K562_Human1.08360562
118ELK1_19687146_ChIP-ChIP_HELA_Human1.07953059
119FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07374756
120MAF_26560356_Chip-Seq_TH2_Human1.07345051
121BCOR_27268052_Chip-Seq_Bcells_Human1.05293525
122* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04759466
123MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02969397
124PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02717784
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02338160
126CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01718323
127CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00128921
128VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99705858
129ETS1_22383799_ChIP-Seq_G1ME_Mouse0.99566709
130SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99168078
131TFEB_21752829_ChIP-Seq_HELA_Human0.97315057
132CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96308609
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95452417
134SPI1_20517297_ChIP-Seq_HL60_Human0.95134014
135* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94636885
136* RUNX_20019798_ChIP-Seq_JUKART_Human0.93804136
137ELK3_25401928_ChIP-Seq_HUVEC_Human0.93766844
138GATA3_26560356_Chip-Seq_TH2_Human0.93328174
139ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88789568
140GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88781084
141STAT1_20625510_ChIP-Seq_HELA_Human0.88572320
142* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88463101
143NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87737794
144YY1_21170310_ChIP-Seq_MESCs_Mouse0.87681438

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.41545588
2MP0002396_abnormal_hematopoietic_system4.25029473
3MP0001835_abnormal_antigen_presentation3.36874783
4MP0004147_increased_porphyrin_level3.34427828
5MP0005174_abnormal_tail_pigmentation3.32218820
6MP0001545_abnormal_hematopoietic_system3.16058342
7MP0005397_hematopoietic_system_phenotyp3.16058342
8MP0005075_abnormal_melanosome_morpholog3.13194589
9MP0004808_abnormal_hematopoietic_stem3.10294367
10MP0000685_abnormal_immune_system2.88391330
11MP0005464_abnormal_platelet_physiology2.84009089
12MP0009785_altered_susceptibility_to2.69946232
13MP0000465_gastrointestinal_hemorrhage2.62317668
14MP0005671_abnormal_response_to2.52875916
15MP0000490_abnormal_crypts_of2.30616656
16* MP0002398_abnormal_bone_marrow2.25798665
17MP0005025_abnormal_response_to2.22327688
18MP0003656_abnormal_erythrocyte_physiolo2.20897295
19MP0002095_abnormal_skin_pigmentation2.20765593
20* MP0000689_abnormal_spleen_morphology2.01907483
21MP0001800_abnormal_humoral_immune2.01471389
22MP0009379_abnormal_foot_pigmentation2.00093450
23MP0002452_abnormal_antigen_presenting1.99425200
24MP0009278_abnormal_bone_marrow1.95190161
25MP0002420_abnormal_adaptive_immunity1.93597942
26MP0003763_abnormal_thymus_physiology1.92803022
27MP0001819_abnormal_immune_cell1.91367925
28MP0003724_increased_susceptibility_to1.91320086
29MP0002723_abnormal_immune_serum1.91242933
30MP0002166_altered_tumor_susceptibility1.90845382
31MP0009333_abnormal_splenocyte_physiolog1.88260191
32MP0003693_abnormal_embryo_hatching1.87946232
33MP0000015_abnormal_ear_pigmentation1.87834011
34* MP0002722_abnormal_immune_system1.85982876
35MP0001873_stomach_inflammation1.82440443
36* MP0000716_abnormal_immune_system1.82383826
37MP0001853_heart_inflammation1.81791904
38MP0002419_abnormal_innate_immunity1.78661776
39* MP0002429_abnormal_blood_cell1.78622410
40MP0005000_abnormal_immune_tolerance1.75565974
41MP0006054_spinal_hemorrhage1.75373652
42MP0002148_abnormal_hypersensitivity_rea1.74977373
43MP0010155_abnormal_intestine_physiology1.74505156
44MP0003436_decreased_susceptibility_to1.71864807
45MP0003866_abnormal_defecation1.68911787
46MP0010094_abnormal_chromosome_stability1.65344419
47MP0003075_altered_response_to1.62190635
48MP0001986_abnormal_taste_sensitivity1.60009521
49MP0008058_abnormal_DNA_repair1.58610638
50MP0008007_abnormal_cellular_replicative1.58126066
51MP0008057_abnormal_DNA_replication1.47275524
52MP0005387_immune_system_phenotype1.45920285
53MP0001790_abnormal_immune_system1.45920285
54MP0000703_abnormal_thymus_morphology1.40223823
55MP0005167_abnormal_blood-brain_barrier1.39673018
56MP0003077_abnormal_cell_cycle1.35549043
57MP0003172_abnormal_lysosome_physiology1.32448792
58MP0002405_respiratory_system_inflammati1.30807706
59MP0002006_tumorigenesis1.30257193
60MP0003690_abnormal_glial_cell1.29449793
61MP0005451_abnormal_body_composition1.29106694
62MP0008004_abnormal_stomach_pH1.28732330
63MP0003943_abnormal_hepatobiliary_system1.28292484
64MP0001845_abnormal_inflammatory_respons1.24091208
65MP0001851_eye_inflammation1.22540242
66MP0008469_abnormal_protein_level1.15590037
67* MP0002019_abnormal_tumor_incidence1.11111395
68MP0004510_myositis1.09994917
69MP0008260_abnormal_autophagy1.09986420
70MP0004957_abnormal_blastocyst_morpholog1.09488468
71MP0000372_irregular_coat_pigmentation1.08138426
72MP0004883_abnormal_blood_vessel1.04983460
73MP0006036_abnormal_mitochondrial_physio1.04357023
74MP0003828_pulmonary_edema1.04102374
75MP0003191_abnormal_cellular_cholesterol1.03615202
76MP0000604_amyloidosis1.02888953
77MP0003111_abnormal_nucleus_morphology1.02726259
78MP0002998_abnormal_bone_remodeling1.02436398
79MP0005083_abnormal_biliary_tract1.02236852
80MP0003183_abnormal_peptide_metabolism1.02006022
81MP0005166_decreased_susceptibility_to1.00340391
82MP0001188_hyperpigmentation0.99112366
83MP0000681_abnormal_thyroid_gland0.98549837
84MP0002132_abnormal_respiratory_system0.98220485
85* MP0000313_abnormal_cell_death0.96869826
86MP0003567_abnormal_fetal_cardiomyocyte0.94886234
87MP0006292_abnormal_olfactory_placode0.93085177
88MP0000343_altered_response_to0.91385091
89MP0005164_abnormal_response_to0.90880566
90MP0002877_abnormal_melanocyte_morpholog0.89237468
91MP0010368_abnormal_lymphatic_system0.88943225
92MP0001348_abnormal_lacrimal_gland0.88111221
93MP0003186_abnormal_redox_activity0.85574182
94MP0003806_abnormal_nucleotide_metabolis0.85159543
95MP0005535_abnormal_body_temperature0.84738898
96MP0002009_preneoplasia0.83249105
97MP0002075_abnormal_coat/hair_pigmentati0.81454675
98MP0000249_abnormal_blood_vessel0.81197621
99MP0005409_darkened_coat_color0.81106851
100MP0002933_joint_inflammation0.81045987
101MP0004130_abnormal_muscle_cell0.79233916
102MP0003868_abnormal_feces_composition0.76197427
103MP0000477_abnormal_intestine_morphology0.76162841
104MP0000371_diluted_coat_color0.76042937
105MP0009840_abnormal_foam_cell0.74643951
106MP0008874_decreased_physiological_sensi0.74266857
107MP0004947_skin_inflammation0.72978161
108MP0005310_abnormal_salivary_gland0.71395948
109MP0001663_abnormal_digestive_system0.71003531
110MP0006082_CNS_inflammation0.70183753
111MP0005084_abnormal_gallbladder_morpholo0.70021386
112MP0009764_decreased_sensitivity_to0.69408657
113MP0005058_abnormal_lysosome_morphology0.68979473
114MP0002332_abnormal_exercise_endurance0.67282160
115MP0005165_increased_susceptibility_to0.66837239
116MP0003786_premature_aging0.66759301
117MP0001764_abnormal_homeostasis0.65938564
118MP0009697_abnormal_copulation0.65287073
119MP0001879_abnormal_lymphatic_vessel0.65190278
120MP0005666_abnormal_adipose_tissue0.64684130
121MP0003638_abnormal_response/metabolism_0.63781816
122MP0005390_skeleton_phenotype0.63599977
123MP0009763_increased_sensitivity_to0.63392467
124MP0003300_gastrointestinal_ulcer0.61595832
125MP0001533_abnormal_skeleton_physiology0.60853012
126MP0003448_altered_tumor_morphology0.60006185
127MP0003787_abnormal_imprinting0.59791310
128MP0009765_abnormal_xenobiotic_induced0.58744087
129* MP0000598_abnormal_liver_morphology0.57946496
130MP0000858_altered_metastatic_potential0.55598459
131MP0008995_early_reproductive_senescence0.54028534
132MP0002928_abnormal_bile_duct0.54003681
133MP0004185_abnormal_adipocyte_glucose0.53676102
134MP0003795_abnormal_bone_structure0.52720988
135MP0003329_amyloid_beta_deposits0.52685689
136MP0005319_abnormal_enzyme/_coenzyme0.52287559
137MP0005584_abnormal_enzyme/coenzyme_acti0.52236617

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.66892441
2Abnormality of cells of the erythroid lineage (HP:0012130)5.58572968
3Abnormal number of erythroid precursors (HP:0012131)5.49191602
4Aplastic anemia (HP:0001915)5.21967766
5Abnormality of the heme biosynthetic pathway (HP:0010472)5.02536024
6Prolonged bleeding time (HP:0003010)4.78085094
7Eczematoid dermatitis (HP:0000976)4.51234553
8Petechiae (HP:0000967)4.47569287
9Chronic otitis media (HP:0000389)4.39250918
10IgM deficiency (HP:0002850)4.10720865
11Stomatitis (HP:0010280)4.06723666
12Obstructive lung disease (HP:0006536)3.97265317
13Chronic obstructive pulmonary disease (HP:0006510)3.97265317
14Reticulocytopenia (HP:0001896)3.92403891
15Reduced antithrombin III activity (HP:0001976)3.88000647
16Elevated erythrocyte sedimentation rate (HP:0003565)3.81690121
17Type I transferrin isoform profile (HP:0003642)3.73878463
18Epistaxis (HP:0000421)3.67524086
19Myositis (HP:0100614)3.65296495
20Recurrent gram-negative bacterial infections (HP:0005420)3.62456966
21Polycythemia (HP:0001901)3.54926622
22Abnormal platelet function (HP:0011869)3.41187776
23Impaired platelet aggregation (HP:0003540)3.41187776
24Pallor (HP:0000980)3.38983933
25Recurrent cutaneous fungal infections (HP:0011370)3.38068195
26Chronic mucocutaneous candidiasis (HP:0002728)3.38068195
27Optic neuritis (HP:0100653)3.34116869
28Retrobulbar optic neuritis (HP:0100654)3.34116869
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.08344052
30Abnormal protein N-linked glycosylation (HP:0012347)3.08344052
31Abnormal protein glycosylation (HP:0012346)3.08344052
32Abnormal glycosylation (HP:0012345)3.08344052
33Encephalitis (HP:0002383)3.00045482
34Recurrent abscess formation (HP:0002722)2.98492906
35Abnormality of T cell physiology (HP:0011840)2.98219451
36Increased cerebral lipofuscin (HP:0011813)2.94111225
37Increased IgE level (HP:0003212)2.91843713
38Abnormality of the nasal mucosa (HP:0000433)2.91823600
39Acute lymphatic leukemia (HP:0006721)2.87564539
40Type 2 muscle fiber atrophy (HP:0003554)2.85330642
41Muscle fiber atrophy (HP:0100295)2.84384973
42Macrocytic anemia (HP:0001972)2.82768339
43Recurrent bronchitis (HP:0002837)2.82295415
44Panhypogammaglobulinemia (HP:0003139)2.79323937
45Urticaria (HP:0001025)2.75785329
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.75753379
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.75753379
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.75381383
49Recurrent bacterial skin infections (HP:0005406)2.69434850
50Amaurosis fugax (HP:0100576)2.67622234
51Abnormality of glycolipid metabolism (HP:0010969)2.67603878
52Abnormality of liposaccharide metabolism (HP:0010968)2.67603878
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.67603878
54Microcytic anemia (HP:0001935)2.65687342
55Acute myeloid leukemia (HP:0004808)2.62561920
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.62517847
57Gastrointestinal infarctions (HP:0005244)2.61884120
58Episodic fever (HP:0001954)2.61807863
59Autoimmune thrombocytopenia (HP:0001973)2.60622156
60Myelodysplasia (HP:0002863)2.60478505
61Gastrointestinal inflammation (HP:0004386)2.59859665
62Poikiloderma (HP:0001029)2.59515938
63Albinism (HP:0001022)2.56627295
64Abnormality of iron homeostasis (HP:0011031)2.55741855
65Gingivitis (HP:0000230)2.54981455
66Dysostosis multiplex (HP:0000943)2.54144796
67Keratoconjunctivitis sicca (HP:0001097)2.53909721
68Severe visual impairment (HP:0001141)2.51630089
69Hemoptysis (HP:0002105)2.51451890
70Inflammation of the large intestine (HP:0002037)2.50510536
71Hypothermia (HP:0002045)2.48371294
72Cellulitis (HP:0100658)2.47993443
73Hypochromic microcytic anemia (HP:0004840)2.47109955
74Granulocytopenia (HP:0001913)2.46405314
75Gingival bleeding (HP:0000225)2.46122345
76Leukocytosis (HP:0001974)2.45576994
77Purpura (HP:0000979)2.43298897
78Amyloidosis (HP:0011034)2.42059157
79Arterial thrombosis (HP:0004420)2.38953645
80Nasal polyposis (HP:0100582)2.38084351
81Spontaneous hematomas (HP:0007420)2.36674411
82Osteomyelitis (HP:0002754)2.36400224
83Recurrent viral infections (HP:0004429)2.36073555
84Pancytopenia (HP:0001876)2.35635170
85Asplenia (HP:0001746)2.33436673
86Meningitis (HP:0001287)2.30988604
87Keratoconjunctivitis (HP:0001096)2.30200532
88Erythema (HP:0010783)2.25664885
89Reticulocytosis (HP:0001923)2.25550538
90Hepatosplenomegaly (HP:0001433)2.24457294
91Pulmonary embolism (HP:0002204)2.24430591
92Lymphoma (HP:0002665)2.23183104
93Systemic lupus erythematosus (HP:0002725)2.21353767
94Vertigo (HP:0002321)2.21107908
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.21081692
96Pulmonary infiltrates (HP:0002113)2.19117401
97Increased IgM level (HP:0003496)2.19114086
98Interstitial pulmonary disease (HP:0006530)2.18051862
99Hypoproteinemia (HP:0003075)2.16620692
100Abnormality of macrophages (HP:0004311)2.16194936
101Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.16181232
102Hepatocellular necrosis (HP:0001404)2.16032470
103Agammaglobulinemia (HP:0004432)2.15416536
104Hypergammaglobulinemia (HP:0010702)2.14646882
105Loss of speech (HP:0002371)2.14177020
106Abnormality of transition element cation homeostasis (HP:0011030)2.13418860
107Abnormality of the prostate (HP:0008775)2.13161053
108Gastrointestinal stroma tumor (HP:0100723)2.12553159
109Hypertensive crisis (HP:0100735)2.12527469
110Recurrent skin infections (HP:0001581)2.11555288
111Abnormality of the columella (HP:0009929)2.09823612
112Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08154803
113IgG deficiency (HP:0004315)2.07865451
114Papilledema (HP:0001085)2.06407601
115Aplasia/Hypoplasia of the spleen (HP:0010451)2.02906524
116Autoimmune hemolytic anemia (HP:0001890)2.02567323
117Paralysis (HP:0003470)2.02418993
118Abnormal platelet volume (HP:0011876)2.02358507
119Colon cancer (HP:0003003)2.01780162
120Abnormality of T cells (HP:0002843)2.01729906
121Hypochromic anemia (HP:0001931)2.01181446
122Thrombophlebitis (HP:0004418)2.01177410
123Recurrent fungal infections (HP:0002841)2.00336064
124Fatigue (HP:0012378)2.00303949
125Polygenic inheritance (HP:0010982)2.00010281
126B lymphocytopenia (HP:0010976)1.99820869
127Abnormality of B cell number (HP:0010975)1.99820869
128Thyroid-stimulating hormone excess (HP:0002925)1.99788047
129Disinhibition (HP:0000734)1.99029417
130Increased intramyocellular lipid droplets (HP:0012240)1.98969275
131Exertional dyspnea (HP:0002875)1.98959079
132Viral hepatitis (HP:0006562)1.98577183
133Chest pain (HP:0100749)1.98384572
134Abnormality of binocular vision (HP:0011514)1.96834140
135Diplopia (HP:0000651)1.96834140
136Increased serum ferritin (HP:0003281)1.96289991
137Colitis (HP:0002583)1.95938582
138Nonprogressive disorder (HP:0003680)1.95604791
139Abnormality of the peritoneum (HP:0002585)1.95182645
140Skin rash (HP:0000988)1.92755428
141Lymphopenia (HP:0001888)1.92577478
142Hematochezia (HP:0002573)1.91420260
143Increased neuronal autofluorescent lipopigment (HP:0002074)1.89771783
144Menorrhagia (HP:0000132)1.89526505
145Increased muscle lipid content (HP:0009058)1.87060203
146Migraine (HP:0002076)1.85096701
147Neutropenia (HP:0001875)1.83906502
148Thoracic kyphosis (HP:0002942)1.83617957
149Abnormality of cells of the lymphoid lineage (HP:0012140)1.83065652
150Orchitis (HP:0100796)1.82207744
151Mediastinal lymphadenopathy (HP:0100721)1.81895321
152Pulmonary fibrosis (HP:0002206)1.80603169
153Hepatic necrosis (HP:0002605)1.80549486
154Chronic sinusitis (HP:0011109)1.79073431
155Vacuolated lymphocytes (HP:0001922)1.77747553
156Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77291084
157Vasculitis (HP:0002633)1.77262018
158Abnormality of reticulocytes (HP:0004312)1.76925303
159Bruising susceptibility (HP:0000978)1.76830028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT3.49658688
2TNIK3.42116436
3FLT32.99469403
4NME22.82557302
5STK162.77686292
6TGFBR12.68074841
7WEE12.61851615
8PRPF4B2.60688526
9MAP4K12.53390069
10CDK192.53272506
11EEF2K2.43243674
12TGFBR22.36339150
13MUSK2.30753922
14BTK2.30281820
15TEC2.23488145
16TIE12.07203661
17CSF1R2.05688106
18CSK1.90279558
19ACVR1B1.90239123
20MAP3K141.88653092
21MATK1.87663775
22MAP2K31.84856696
23PIM21.78236387
24JAK31.64895812
25RPS6KB21.50160979
26BRSK21.49849880
27VRK11.45808506
28BMPR21.43883930
29MAPKAPK51.42953485
30MAP3K11.41265253
31MAP3K131.40330178
32MAP3K121.40238873
33SYK1.40033512
34DYRK31.36662209
35TBK11.29462185
36SCYL21.28882130
37ZAP701.26305247
38CAMKK21.26140350
39MAP3K31.23311111
40FES1.21762208
41MKNK11.21424029
42IRAK41.19906050
43KDR1.15782523
44NLK1.14146756
45MAPK121.11920556
46TAOK21.11545861
47MAPKAPK31.10257649
48IKBKB1.09813524
49PIM11.08073353
50IKBKE1.06306661
51TYK21.03948827
52MAP3K61.02200895
53ITK1.01641372
54CDK80.99131222
55LRRK20.98593331
56LYN0.96991296
57IRAK10.95859860
58IRAK20.95026083
59BCKDK0.93454650
60CCNB10.92925754
61TAOK30.92296870
62MARK20.88439687
63DAPK20.87985263
64FGR0.87122645
65TAOK10.85112443
66PRKG20.84909247
67PKN20.83837783
68ADRBK20.82095325
69LCK0.81465969
70JAK10.78893684
71MAP2K60.77195953
72MAPK40.76626797
73MAP3K110.75957133
74CAMK10.75382595
75NEK20.75210196
76BUB10.75131936
77MARK30.75080000
78CDK70.74741559
79CDC70.73923628
80MAPK70.73699582
81TXK0.73183880
82PIK3CG0.72884710
83BLK0.72660386
84TESK20.72031027
85PRKCQ0.71541025
86MKNK20.71178479
87DAPK10.68318769
88EIF2AK30.66622580
89HIPK20.66415433
90MAP3K70.65521815
91ERN10.64527635
92PDK10.64310785
93CDK40.64209972
94PASK0.63918957
95MAPK110.59421190
96RPS6KA40.58645948
97MAP2K40.58290274
98PAK40.58074616
99ATR0.57795522
100HCK0.56363149
101EIF2AK10.56333845
102YES10.54923143
103PDPK10.54227368
104RAF10.53249937
105MAP3K50.52799192
106TNK20.51848146
107TLK10.48623648
108RPS6KA60.47862464
109STK100.47585099
110MAP2K20.47314269
111RIPK40.47313653
112MYLK0.46803828
113BRSK10.46756593
114DYRK1B0.45581284
115MAPK150.44940913
116STK40.44366272
117CDK60.41539786
118EPHB10.41101768
119KSR20.39525940
120TSSK60.39465935
121FYN0.38869239
122RPS6KA20.37980198
123RPS6KL10.37834100
124RPS6KC10.37834100
125ABL20.36634901
126GRK60.35297720
127SIK20.34654179
128PRKCD0.33935936
129AURKB0.33806538
130IRAK30.33570618
131JAK20.33545044
132RET0.33258179
133CLK10.32345104
134ABL10.32300313
135SGK20.31086239
136EIF2AK20.31000555
137GRK70.30708983
138NEK90.30402092
139TRPM70.30372954
140MAPK30.30274317
141SGK30.28661024
142PRKD20.27961597
143STK110.25382502

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.07819499
2DNA replication_Homo sapiens_hsa030304.61620283
3Mismatch repair_Homo sapiens_hsa034303.45547861
4Base excision repair_Homo sapiens_hsa034102.86288167
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.80738140
6Staphylococcus aureus infection_Homo sapiens_hsa051502.57476873
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.30881599
8Homologous recombination_Homo sapiens_hsa034402.29070265
9Spliceosome_Homo sapiens_hsa030402.13879605
10Pyrimidine metabolism_Homo sapiens_hsa002402.11943059
11Primary immunodeficiency_Homo sapiens_hsa053402.07689118
12Nucleotide excision repair_Homo sapiens_hsa034202.05692543
13Graft-versus-host disease_Homo sapiens_hsa053321.95046368
14Autoimmune thyroid disease_Homo sapiens_hsa053201.91085675
15RNA polymerase_Homo sapiens_hsa030201.81916672
16Sulfur relay system_Homo sapiens_hsa041221.79546216
17B cell receptor signaling pathway_Homo sapiens_hsa046621.66853574
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61889166
19Herpes simplex infection_Homo sapiens_hsa051681.61177686
20Type I diabetes mellitus_Homo sapiens_hsa049401.60601826
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59995850
22Other glycan degradation_Homo sapiens_hsa005111.56639450
23Leishmaniasis_Homo sapiens_hsa051401.55130752
24Rheumatoid arthritis_Homo sapiens_hsa053231.53933342
25Hematopoietic cell lineage_Homo sapiens_hsa046401.50797674
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49575911
27* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.40375543
28N-Glycan biosynthesis_Homo sapiens_hsa005101.39025160
29Measles_Homo sapiens_hsa051621.38860598
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38320094
31Antigen processing and presentation_Homo sapiens_hsa046121.37664667
32Proteasome_Homo sapiens_hsa030501.36538386
33RNA degradation_Homo sapiens_hsa030181.32778716
34Chemokine signaling pathway_Homo sapiens_hsa040621.31001767
35Cell cycle_Homo sapiens_hsa041101.29726007
36Fanconi anemia pathway_Homo sapiens_hsa034601.25254021
37Folate biosynthesis_Homo sapiens_hsa007901.24785061
38Platelet activation_Homo sapiens_hsa046111.22747403
39Non-homologous end-joining_Homo sapiens_hsa034501.21542759
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.19913413
41Phagosome_Homo sapiens_hsa041451.19650742
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19426418
43Acute myeloid leukemia_Homo sapiens_hsa052211.18278992
44Lysosome_Homo sapiens_hsa041421.17993680
45T cell receptor signaling pathway_Homo sapiens_hsa046601.17367126
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.15088110
47Caffeine metabolism_Homo sapiens_hsa002321.14214369
48Shigellosis_Homo sapiens_hsa051311.10398295
49Purine metabolism_Homo sapiens_hsa002301.10363073
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09879819
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.08502197
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03059806
53Viral myocarditis_Homo sapiens_hsa054161.02963696
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98131495
55Thyroid cancer_Homo sapiens_hsa052160.97035863
56VEGF signaling pathway_Homo sapiens_hsa043700.97000904
57Non-small cell lung cancer_Homo sapiens_hsa052230.95625979
58Basal transcription factors_Homo sapiens_hsa030220.95581394
59Systemic lupus erythematosus_Homo sapiens_hsa053220.95003495
60RNA transport_Homo sapiens_hsa030130.92025337
61p53 signaling pathway_Homo sapiens_hsa041150.92020859
62Osteoclast differentiation_Homo sapiens_hsa043800.91080303
63Legionellosis_Homo sapiens_hsa051340.88416477
64Pancreatic cancer_Homo sapiens_hsa052120.88282409
65Protein export_Homo sapiens_hsa030600.87861506
66Hepatitis B_Homo sapiens_hsa051610.86334285
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.86037999
68Prolactin signaling pathway_Homo sapiens_hsa049170.85895044
69Pertussis_Homo sapiens_hsa051330.84322154
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82495752
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80914314
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80471476
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80399303
74Dorso-ventral axis formation_Homo sapiens_hsa043200.80266627
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80040798
76Influenza A_Homo sapiens_hsa051640.79685175
77Pentose phosphate pathway_Homo sapiens_hsa000300.78522025
78Epstein-Barr virus infection_Homo sapiens_hsa051690.78043583
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77362391
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.76364387
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75085119
82One carbon pool by folate_Homo sapiens_hsa006700.74961295
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73256247
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.71752676
85Apoptosis_Homo sapiens_hsa042100.71638969
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71450781
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70222685
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69130199
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68715288
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67665095
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.66811047
92Renal cell carcinoma_Homo sapiens_hsa052110.66669436
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66465618
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.66392205
95Notch signaling pathway_Homo sapiens_hsa043300.66322858
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65221061
97Amoebiasis_Homo sapiens_hsa051460.64781640
98GnRH signaling pathway_Homo sapiens_hsa049120.64636636
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.64216792
100Malaria_Homo sapiens_hsa051440.62816037
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61065299
102Viral carcinogenesis_Homo sapiens_hsa052030.60471228
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59337440
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58754557
105MAPK signaling pathway_Homo sapiens_hsa040100.58254839
106Galactose metabolism_Homo sapiens_hsa000520.57883394
107Toxoplasmosis_Homo sapiens_hsa051450.57481476
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.55275693
109Endocytosis_Homo sapiens_hsa041440.54754686
110Chronic myeloid leukemia_Homo sapiens_hsa052200.54497869
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53845533
112Salmonella infection_Homo sapiens_hsa051320.52865441
113HIF-1 signaling pathway_Homo sapiens_hsa040660.52769244
114Prion diseases_Homo sapiens_hsa050200.52582614
115Tuberculosis_Homo sapiens_hsa051520.52432581
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50771140
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49381184
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48771582
119Choline metabolism in cancer_Homo sapiens_hsa052310.48233485
120Type II diabetes mellitus_Homo sapiens_hsa049300.46400421
121Estrogen signaling pathway_Homo sapiens_hsa049150.44818651
122mTOR signaling pathway_Homo sapiens_hsa041500.44248084
123Allograft rejection_Homo sapiens_hsa053300.42737739
124Collecting duct acid secretion_Homo sapiens_hsa049660.41225213
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40676415
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.40422908
127HTLV-I infection_Homo sapiens_hsa051660.40158653
128Regulation of autophagy_Homo sapiens_hsa041400.39843380
129Inositol phosphate metabolism_Homo sapiens_hsa005620.39740540
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38818151
131Selenocompound metabolism_Homo sapiens_hsa004500.37282136
132ABC transporters_Homo sapiens_hsa020100.36860260
133TNF signaling pathway_Homo sapiens_hsa046680.36616473
134FoxO signaling pathway_Homo sapiens_hsa040680.36516485
135African trypanosomiasis_Homo sapiens_hsa051430.36061327
136Alcoholism_Homo sapiens_hsa050340.35215193
137Oxytocin signaling pathway_Homo sapiens_hsa049210.34817491
138Small cell lung cancer_Homo sapiens_hsa052220.34675162
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34213781
140Renin secretion_Homo sapiens_hsa049240.33946868
141Asthma_Homo sapiens_hsa053100.33777037
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.32731106
143Arachidonic acid metabolism_Homo sapiens_hsa005900.32631828
144Insulin resistance_Homo sapiens_hsa049310.31868076
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.30197532
146Hepatitis C_Homo sapiens_hsa051600.29807980

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »