LMO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.53028367
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.47748852
3ionotropic glutamate receptor signaling pathway (GO:0035235)5.39566845
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.38465240
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.25627548
6neuron cell-cell adhesion (GO:0007158)5.25093376
7synaptic vesicle exocytosis (GO:0016079)5.22833722
8regulation of glutamate receptor signaling pathway (GO:1900449)4.95771765
9protein localization to synapse (GO:0035418)4.91463612
10glutamate receptor signaling pathway (GO:0007215)4.86910256
11locomotory exploration behavior (GO:0035641)4.80444402
12neuron-neuron synaptic transmission (GO:0007270)4.61495075
13synaptic transmission, glutamatergic (GO:0035249)4.60537877
14glutamate secretion (GO:0014047)4.59886831
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.59837435
16synaptic vesicle maturation (GO:0016188)4.52556332
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.50966424
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.50760756
19regulation of synaptic vesicle exocytosis (GO:2000300)4.44594046
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.44234528
21neurotransmitter-gated ion channel clustering (GO:0072578)4.39315909
22response to histamine (GO:0034776)4.33884846
23exploration behavior (GO:0035640)4.28953192
24regulation of neuronal synaptic plasticity (GO:0048168)4.21445238
25regulation of synapse structural plasticity (GO:0051823)4.17282153
26neuron recognition (GO:0008038)4.12330320
27regulation of excitatory postsynaptic membrane potential (GO:0060079)4.11793385
28neuronal action potential propagation (GO:0019227)4.11057980
29regulation of synaptic vesicle transport (GO:1902803)4.07003434
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.00657281
31neurotransmitter secretion (GO:0007269)3.94408912
32long-term synaptic potentiation (GO:0060291)3.91030992
33regulation of postsynaptic membrane potential (GO:0060078)3.88745109
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.87027106
35presynaptic membrane assembly (GO:0097105)3.86609243
36behavioral response to cocaine (GO:0048148)3.79926096
37prepulse inhibition (GO:0060134)3.79399048
38long-term memory (GO:0007616)3.79325584
39axonal fasciculation (GO:0007413)3.76144970
40positive regulation of membrane potential (GO:0045838)3.75421109
41behavioral defense response (GO:0002209)3.73972791
42behavioral fear response (GO:0001662)3.73972791
43regulation of synaptic plasticity (GO:0048167)3.72168009
44regulation of dendritic spine morphogenesis (GO:0061001)3.72154283
45pyrimidine nucleobase catabolic process (GO:0006208)3.71318790
46dendritic spine morphogenesis (GO:0060997)3.70272838
47positive regulation of synapse maturation (GO:0090129)3.70260127
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.69767266
49synaptic transmission, dopaminergic (GO:0001963)3.67539891
50membrane depolarization during action potential (GO:0086010)3.67215597
51postsynaptic membrane organization (GO:0001941)3.65300949
52adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.64007507
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.63992881
54gamma-aminobutyric acid transport (GO:0015812)3.63523388
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60632684
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.60092472
57presynaptic membrane organization (GO:0097090)3.59393158
58cellular potassium ion homeostasis (GO:0030007)3.58978661
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.58355292
60serotonin metabolic process (GO:0042428)3.58115586
61layer formation in cerebral cortex (GO:0021819)3.51945135
62synaptic vesicle endocytosis (GO:0048488)3.50572977
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.50135626
64positive regulation of neurotransmitter secretion (GO:0001956)3.48488716
65transmission of nerve impulse (GO:0019226)3.47781332
66regulation of glutamate secretion (GO:0014048)3.47427393
67striatum development (GO:0021756)3.46296435
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.43163481
69fear response (GO:0042596)3.42655500
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.41909046
71regulation of female receptivity (GO:0045924)3.38326561
72regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.37795549
73regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.37795549
74positive regulation of neurotransmitter transport (GO:0051590)3.35236612
75learning (GO:0007612)3.34757799
76startle response (GO:0001964)3.34133985
77innervation (GO:0060384)3.32802798
78response to amphetamine (GO:0001975)3.31186699
79central nervous system projection neuron axonogenesis (GO:0021952)3.29930440
80female mating behavior (GO:0060180)3.25693409
81neurotransmitter transport (GO:0006836)3.25203334
82membrane depolarization (GO:0051899)3.23455389
83auditory behavior (GO:0031223)3.23045001
84dopamine receptor signaling pathway (GO:0007212)3.21071176
85long term synaptic depression (GO:0060292)3.19987274
86regulation of dendritic spine development (GO:0060998)3.18169290
87proline transport (GO:0015824)3.15091748
88synapse assembly (GO:0007416)3.14845536
89nucleobase catabolic process (GO:0046113)3.14823869
90regulation of neurotransmitter secretion (GO:0046928)3.14209931
91primary amino compound metabolic process (GO:1901160)3.13908665
92regulation of vesicle fusion (GO:0031338)3.12886263
93behavioral response to nicotine (GO:0035095)3.12146645
94activation of protein kinase A activity (GO:0034199)3.10577600
95positive regulation of synaptic transmission (GO:0050806)3.10387178
96positive regulation of dendritic spine development (GO:0060999)3.08792747
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08002837
98regulation of neurotransmitter transport (GO:0051588)3.06467713
99dendritic spine organization (GO:0097061)3.05649973
100response to auditory stimulus (GO:0010996)3.03424463
101synaptic transmission (GO:0007268)3.02914628
102regulation of neurotransmitter uptake (GO:0051580)3.02861288
103L-amino acid import (GO:0043092)3.02767989
104negative regulation of dendrite development (GO:2000171)3.02673023
105regulation of neurotransmitter levels (GO:0001505)3.02538980
106regulation of synaptic transmission (GO:0050804)3.02372312
107regulation of voltage-gated calcium channel activity (GO:1901385)3.01642347
108mechanosensory behavior (GO:0007638)3.00903593
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00531270
110membrane hyperpolarization (GO:0060081)2.99268806
111regulation of synapse maturation (GO:0090128)2.97699593
112positive regulation of dendritic spine morphogenesis (GO:0061003)2.96472930
113dendrite morphogenesis (GO:0048813)2.95907259
114axon ensheathment in central nervous system (GO:0032291)2.93403553
115central nervous system myelination (GO:0022010)2.93403553
116neuronal action potential (GO:0019228)2.92854471
117sodium ion export (GO:0071436)2.87858195
118adaptation of signaling pathway (GO:0023058)2.84946888
119cerebellar granule cell differentiation (GO:0021707)2.82013321
120adult walking behavior (GO:0007628)2.81576291
121neuromuscular synaptic transmission (GO:0007274)2.81469519
122positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80437632
123neuronal ion channel clustering (GO:0045161)2.79256294
124positive regulation of potassium ion transmembrane transport (GO:1901381)2.77919714
125neurotransmitter uptake (GO:0001504)2.77130461
126cerebellar Purkinje cell differentiation (GO:0021702)2.75597027
127regulation of collateral sprouting (GO:0048670)2.73581427
128positive regulation of synapse assembly (GO:0051965)2.71907456
129central nervous system neuron axonogenesis (GO:0021955)2.71841094
130glycosphingolipid biosynthetic process (GO:0006688)2.71783204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.25396671
2GBX2_23144817_ChIP-Seq_PC3_Human4.06546707
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21036946
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11040620
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05933953
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72684530
7REST_21632747_ChIP-Seq_MESCs_Mouse2.69863619
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65897123
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65897123
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.61832117
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61375683
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.61162831
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55834624
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51689083
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40069359
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39839070
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.31377302
18TAF15_26573619_Chip-Seq_HEK293_Human2.28707216
19DROSHA_22980978_ChIP-Seq_HELA_Human2.17558233
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17297435
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.15612395
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15193021
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.14879008
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14008981
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.12375175
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05015512
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01085105
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99185378
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97793899
30AR_21572438_ChIP-Seq_LNCaP_Human1.94174138
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87285319
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85480750
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.78696699
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75830652
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74096519
36P300_19829295_ChIP-Seq_ESCs_Human1.73344687
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72407422
38* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60436123
39ZNF274_21170338_ChIP-Seq_K562_Hela1.57879814
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54659398
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.52327537
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49714488
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.49328587
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46184415
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45548358
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45177236
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42665083
48FUS_26573619_Chip-Seq_HEK293_Human1.39574229
49* AR_25329375_ChIP-Seq_VCAP_Human1.39418753
50IGF1R_20145208_ChIP-Seq_DFB_Human1.38437318
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.37883116
52* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35795330
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35309563
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.34483554
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33985260
56RNF2_27304074_Chip-Seq_NSC_Mouse1.33741019
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33224712
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.32690140
59VDR_22108803_ChIP-Seq_LS180_Human1.31305958
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30961520
61* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30713606
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28025223
63STAT3_23295773_ChIP-Seq_U87_Human1.26216098
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23912086
65* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22283465
66EWS_26573619_Chip-Seq_HEK293_Human1.21624664
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.20947140
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19100512
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17436938
70TCF4_23295773_ChIP-Seq_U87_Human1.14140862
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.13673736
72AR_19668381_ChIP-Seq_PC3_Human1.12824868
73RUNX2_22187159_ChIP-Seq_PCA_Human1.12719710
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.12671778
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12488155
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12368685
77CBP_20019798_ChIP-Seq_JUKART_Human1.12368685
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11957602
79JUN_21703547_ChIP-Seq_K562_Human1.08279628
80SOX9_26525672_Chip-Seq_HEART_Mouse1.07648747
81* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06900975
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.06224155
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05740439
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04870965
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.04687902
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03958279
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03954159
88TP53_16413492_ChIP-PET_HCT116_Human1.03525953
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03454765
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03259713
91* KDM2B_26808549_Chip-Seq_REH_Human1.03208491
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02425958
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02425958
94BCAT_22108803_ChIP-Seq_LS180_Human1.02047313
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.02016193
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01778634
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01409723
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01333728
99ER_23166858_ChIP-Seq_MCF-7_Human1.01172869
100AHR_22903824_ChIP-Seq_MCF-7_Human1.01038236
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00891626
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.00287532
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00167438
104TP53_18474530_ChIP-ChIP_U2OS_Human0.99899213
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99719780
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99245758
107SALL1_21062744_ChIP-ChIP_HESCs_Human0.98812466
108CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96003082
109TAL1_26923725_Chip-Seq_HPCs_Mouse0.96001835
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95020826
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94402221
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93825683
113DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93141352
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.92452317
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91173788
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.91088489
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90998024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.51411721
2MP0003880_abnormal_central_pattern5.76544377
3MP0003635_abnormal_synaptic_transmissio4.21522951
4MP0004270_analgesia3.61443713
5MP0009745_abnormal_behavioral_response3.59542999
6MP0002063_abnormal_learning/memory/cond3.59456520
7MP0002064_seizures3.14654062
8MP0001968_abnormal_touch/_nociception3.12584441
9MP0002822_catalepsy3.08735968
10MP0002572_abnormal_emotion/affect_behav3.03841107
11MP0009046_muscle_twitch2.71938718
12MP0002736_abnormal_nociception_after2.66558439
13MP0001486_abnormal_startle_reflex2.60541257
14MP0002272_abnormal_nervous_system2.53457609
15MP0005423_abnormal_somatic_nervous2.42189991
16MP0001440_abnormal_grooming_behavior2.40105613
17MP0002734_abnormal_mechanical_nocicepti2.38618691
18MP0002735_abnormal_chemical_nociception2.27674271
19MP0001501_abnormal_sleep_pattern2.27503601
20MP0001529_abnormal_vocalization2.22779907
21MP0000778_abnormal_nervous_system2.03623417
22MP0002067_abnormal_sensory_capabilities1.96800762
23MP0002733_abnormal_thermal_nociception1.95367009
24MP0003787_abnormal_imprinting1.93254564
25MP0001970_abnormal_pain_threshold1.89407343
26MP0002184_abnormal_innervation1.82761858
27MP0005646_abnormal_pituitary_gland1.82507364
28MP0001905_abnormal_dopamine_level1.79462514
29MP0004924_abnormal_behavior1.77527205
30MP0005386_behavior/neurological_phenoty1.77527205
31MP0002557_abnormal_social/conspecific_i1.77415056
32MP0006276_abnormal_autonomic_nervous1.77262319
33MP0002909_abnormal_adrenal_gland1.71188335
34MP0009780_abnormal_chondrocyte_physiolo1.69305860
35MP0004811_abnormal_neuron_physiology1.63194434
36MP0001984_abnormal_olfaction1.62295120
37MP0001188_hyperpigmentation1.62025984
38MP0008569_lethality_at_weaning1.54988740
39MP0003879_abnormal_hair_cell1.51375065
40MP0003329_amyloid_beta_deposits1.46535711
41MP0003122_maternal_imprinting1.43589949
42MP0000955_abnormal_spinal_cord1.39368936
43MP0008877_abnormal_DNA_methylation1.39238353
44MP0002066_abnormal_motor_capabilities/c1.37960494
45MP0002882_abnormal_neuron_morphology1.34989868
46MP0002102_abnormal_ear_morphology1.25404067
47MP0004858_abnormal_nervous_system1.22433815
48MP0004885_abnormal_endolymph1.20305947
49MP0004142_abnormal_muscle_tone1.20027893
50MP0001502_abnormal_circadian_rhythm1.18911841
51MP0000049_abnormal_middle_ear1.18267575
52MP0002837_dystrophic_cardiac_calcinosis1.17111589
53MP0003938_abnormal_ear_development1.15656651
54MP0002152_abnormal_brain_morphology1.12219654
55MP0010386_abnormal_urinary_bladder1.09813125
56MP0003633_abnormal_nervous_system1.07660739
57MP0005645_abnormal_hypothalamus_physiol1.06974674
58MP0008872_abnormal_physiological_respon1.06040220
59MP0000569_abnormal_digit_pigmentation1.04401214
60MP0005409_darkened_coat_color1.04079046
61MP0000566_synostosis1.01876122
62MP0006072_abnormal_retinal_apoptosis0.99860332
63MP0002069_abnormal_eating/drinking_beha0.97439687
64MP0005253_abnormal_eye_physiology0.97360828
65MP0002751_abnormal_autonomic_nervous0.97307646
66MP0000751_myopathy0.96658081
67MP0003631_nervous_system_phenotype0.94894796
68MP0002876_abnormal_thyroid_physiology0.94037558
69MP0002234_abnormal_pharynx_morphology0.92812857
70MP0004133_heterotaxia0.91559832
71MP0004742_abnormal_vestibular_system0.90423069
72MP0008874_decreased_physiological_sensi0.89016636
73MP0000631_abnormal_neuroendocrine_gland0.88888307
74MP0005499_abnormal_olfactory_system0.86972383
75MP0005394_taste/olfaction_phenotype0.86972383
76MP0004085_abnormal_heartbeat0.85829127
77MP0005551_abnormal_eye_electrophysiolog0.85274115
78MP0008789_abnormal_olfactory_epithelium0.84892237
79MP0001963_abnormal_hearing_physiology0.83259725
80MP0002653_abnormal_ependyma_morphology0.81598120
81MP0003119_abnormal_digestive_system0.81191834
82MP0001177_atelectasis0.80310916
83MP0005535_abnormal_body_temperature0.79682465
84MP0002229_neurodegeneration0.78190513
85MP0001664_abnormal_digestion0.78006521
86MP0003690_abnormal_glial_cell0.74854255
87MP0004145_abnormal_muscle_electrophysio0.72890586
88MP0004130_abnormal_muscle_cell0.72714386
89MP0001986_abnormal_taste_sensitivity0.72465447
90MP0002752_abnormal_somatic_nervous0.70925161
91MP0004215_abnormal_myocardial_fiber0.69166897
92MP0005195_abnormal_posterior_eye0.69125391
93MP0005167_abnormal_blood-brain_barrier0.68361851
94MP0004484_altered_response_of0.66997753
95MP0001485_abnormal_pinna_reflex0.66614587
96MP0003137_abnormal_impulse_conducting0.65421836
97MP0000013_abnormal_adipose_tissue0.64047207
98MP0003634_abnormal_glial_cell0.63599531
99MP0003890_abnormal_embryonic-extraembry0.63518843
100MP0004147_increased_porphyrin_level0.63515668
101MP0003121_genomic_imprinting0.62815944
102MP0006292_abnormal_olfactory_placode0.61832361
103MP0003632_abnormal_nervous_system0.60118952
104MP0003861_abnormal_nervous_system0.59939950
105MP0004134_abnormal_chest_morphology0.59404218
106MP0002090_abnormal_vision0.57921024
107MP0000604_amyloidosis0.56909543
108MP0003283_abnormal_digestive_organ0.56534454
109MP0000026_abnormal_inner_ear0.56485480
110MP0005187_abnormal_penis_morphology0.55968688
111MP0003075_altered_response_to0.54994309
112MP0001943_abnormal_respiration0.53102029
113MP0002638_abnormal_pupillary_reflex0.51290018
114MP0005171_absent_coat_pigmentation0.50059563
115MP0010769_abnormal_survival0.48566960
116MP0002082_postnatal_lethality0.48459849
117MP0010770_preweaning_lethality0.48459849
118MP0003956_abnormal_body_size0.47625267
119MP0008961_abnormal_basal_metabolism0.46918706
120MP0000920_abnormal_myelination0.46070446
121MP0010768_mortality/aging0.45766203
122MP0003183_abnormal_peptide_metabolism0.44860903

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.59878805
2Myokymia (HP:0002411)6.62113711
3Focal seizures (HP:0007359)5.90334132
4Epileptic encephalopathy (HP:0200134)5.27487989
5Atonic seizures (HP:0010819)4.77824814
6Visual hallucinations (HP:0002367)4.77549354
7Febrile seizures (HP:0002373)4.54043733
8Hyperventilation (HP:0002883)4.42101338
9Progressive cerebellar ataxia (HP:0002073)4.31851642
10Absence seizures (HP:0002121)4.24170535
11Dialeptic seizures (HP:0011146)3.98328409
12Generalized tonic-clonic seizures (HP:0002069)3.91340390
13Broad-based gait (HP:0002136)3.78894319
14Amblyopia (HP:0000646)3.59623572
15Gaze-evoked nystagmus (HP:0000640)3.46469035
16Impaired vibration sensation in the lower limbs (HP:0002166)3.33703442
17Poor eye contact (HP:0000817)3.09854887
18Anxiety (HP:0000739)3.06811218
19Depression (HP:0000716)2.99195449
20Truncal ataxia (HP:0002078)2.98708674
21Drooling (HP:0002307)2.95643579
22Excessive salivation (HP:0003781)2.95643579
23Abnormal eating behavior (HP:0100738)2.94483997
24Epileptiform EEG discharges (HP:0011182)2.93029135
25Limb dystonia (HP:0002451)2.89899706
26Dysdiadochokinesis (HP:0002075)2.88810506
27Supranuclear gaze palsy (HP:0000605)2.87492660
28Progressive inability to walk (HP:0002505)2.87304593
29Action tremor (HP:0002345)2.85919313
30Dysmetria (HP:0001310)2.84386937
31Impaired social interactions (HP:0000735)2.75589609
32Abnormal social behavior (HP:0012433)2.75589609
33Urinary bladder sphincter dysfunction (HP:0002839)2.68537998
34True hermaphroditism (HP:0010459)2.64724307
35Hemiplegia (HP:0002301)2.62146531
36EEG with generalized epileptiform discharges (HP:0011198)2.62043280
37Abnormality of the labia minora (HP:0012880)2.59830849
38Abnormality of binocular vision (HP:0011514)2.57406401
39Diplopia (HP:0000651)2.57406401
40Cerebral inclusion bodies (HP:0100314)2.56711915
41Impaired smooth pursuit (HP:0007772)2.53897921
42Absent speech (HP:0001344)2.52698740
43Polyphagia (HP:0002591)2.52198581
44Nephronophthisis (HP:0000090)2.51237946
45Ankle clonus (HP:0011448)2.50544043
46Mutism (HP:0002300)2.50465071
47Focal dystonia (HP:0004373)2.49510087
48Torticollis (HP:0000473)2.47924481
49Fetal akinesia sequence (HP:0001989)2.45816385
50Hypsarrhythmia (HP:0002521)2.45395543
51Inability to walk (HP:0002540)2.44675404
52Stereotypic behavior (HP:0000733)2.43023755
53Hemiparesis (HP:0001269)2.42750530
54Abnormality of the lower motor neuron (HP:0002366)2.42083050
55Pancreatic fibrosis (HP:0100732)2.41932634
56Pendular nystagmus (HP:0012043)2.40982786
57Thyroid-stimulating hormone excess (HP:0002925)2.39112224
58Postural instability (HP:0002172)2.37385962
59Dysmetric saccades (HP:0000641)2.36648257
60Termporal pattern (HP:0011008)2.36562180
61Insidious onset (HP:0003587)2.36562180
62Bradykinesia (HP:0002067)2.36054147
63Pancreatic cysts (HP:0001737)2.34042400
64Urinary urgency (HP:0000012)2.32353332
65Impaired vibratory sensation (HP:0002495)2.30731007
66Gait imbalance (HP:0002141)2.30570521
67Blue irides (HP:0000635)2.30300414
68Papilledema (HP:0001085)2.29728238
69Abolished electroretinogram (ERG) (HP:0000550)2.29443342
70Genetic anticipation (HP:0003743)2.28844914
71Protruding tongue (HP:0010808)2.27258914
72Pheochromocytoma (HP:0002666)2.23258573
73Scanning speech (HP:0002168)2.21282269
74Abnormality of ocular smooth pursuit (HP:0000617)2.20466988
75Absent/shortened dynein arms (HP:0200106)2.19689692
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.19689692
77Incomplete penetrance (HP:0003829)2.17679135
78Neurofibrillary tangles (HP:0002185)2.16307167
79Abnormal hair whorl (HP:0010721)2.13690339
80Agitation (HP:0000713)2.12067585
81Generalized myoclonic seizures (HP:0002123)2.11751538
82Craniofacial dystonia (HP:0012179)2.10674372
83Spastic gait (HP:0002064)2.09026752
84Annular pancreas (HP:0001734)2.09025639
85Delusions (HP:0000746)2.07672578
86Molar tooth sign on MRI (HP:0002419)2.02479202
87Abnormality of midbrain morphology (HP:0002418)2.02479202
88Status epilepticus (HP:0002133)2.01174388
89Abnormality of the corticospinal tract (HP:0002492)2.00357178
90Abnormality of salivation (HP:0100755)1.99838643
91Intention tremor (HP:0002080)1.99207261
92Specific learning disability (HP:0001328)1.96744620
93Megalencephaly (HP:0001355)1.94572474
94Split foot (HP:0001839)1.94039391
95Neuroendocrine neoplasm (HP:0100634)1.93899640
96Amyotrophic lateral sclerosis (HP:0007354)1.93733642
97Optic nerve hypoplasia (HP:0000609)1.91647737
98Congenital primary aphakia (HP:0007707)1.91237729
99Vaginal atresia (HP:0000148)1.90766303
100Genital tract atresia (HP:0001827)1.89333292
101Decreased central vision (HP:0007663)1.88595429
102Septo-optic dysplasia (HP:0100842)1.87824390
103Medial flaring of the eyebrow (HP:0010747)1.87707702
104Dyskinesia (HP:0100660)1.86621317
105Thickened helices (HP:0000391)1.86431586
106Psychosis (HP:0000709)1.85208084
107Failure to thrive in infancy (HP:0001531)1.84753151
108Hypothermia (HP:0002045)1.84331875
109Gait ataxia (HP:0002066)1.84094190
110Hyperthyroidism (HP:0000836)1.83740956
111Abnormality of the renal medulla (HP:0100957)1.83117272
112Lower limb muscle weakness (HP:0007340)1.81539853
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80701176
114Cutaneous finger syndactyly (HP:0010554)1.80472710
115Sleep apnea (HP:0010535)1.79374190
116Lower limb asymmetry (HP:0100559)1.79352550
117Chronic hepatic failure (HP:0100626)1.79109862
118Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78781995
119Degeneration of the lateral corticospinal tracts (HP:0002314)1.78781995
120Resting tremor (HP:0002322)1.78648048
121Nephrogenic diabetes insipidus (HP:0009806)1.78623414
122Type II lissencephaly (HP:0007260)1.78137812
123Morphological abnormality of the pyramidal tract (HP:0002062)1.77461061
124Abnormal respiratory motile cilium morphology (HP:0005938)1.77425682
125Abnormal respiratory epithelium morphology (HP:0012253)1.77425682
126Generalized hypopigmentation of hair (HP:0011358)1.77026588
127Autism (HP:0000717)1.75983441
128Abnormal ciliary motility (HP:0012262)1.75493264
129Retinal dysplasia (HP:0007973)1.74857489
130Hydroureter (HP:0000072)1.74219007
131Esotropia (HP:0000565)1.73336846
132Cystic liver disease (HP:0006706)1.73096790
133Heterochromia iridis (HP:0001100)1.73009903

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.25749136
2NTRK34.58604790
3MAP3K93.15451264
4MAP3K43.11623351
5MAP3K122.92275011
6MARK12.90199726
7MAP2K72.84113816
8CASK2.75203993
9RIPK42.54722963
10MINK12.48409302
11DAPK22.14385575
12KSR12.06329922
13FRK2.06019803
14MAP2K41.96745933
15PLK21.93526196
16DAPK11.92957106
17PRPF4B1.88040464
18KSR21.81366917
19CDK191.79618514
20NTRK21.73629154
21PAK61.67968658
22ARAF1.63701455
23PNCK1.63307449
24TNIK1.49000786
25CDK51.45021669
26MAPK131.43803662
27SIK21.41554001
28DYRK21.41058083
29SIK31.40611227
30MAP4K21.37173295
31GRK11.32756226
32CAMKK11.31506552
33GRK51.29394811
34BMPR21.29244101
35PRKCG1.26015103
36PTK2B1.25827459
37FES1.22327515
38NME11.18027990
39CAMK2A1.16536379
40PRKD31.13111225
41CAMK2B1.12390629
42MAP3K131.09944135
43NTRK11.05997621
44MAPKAPK51.04659263
45MKNK21.03310898
46PKN11.02878372
47FGFR21.00653622
48OXSR11.00056068
49CSNK1G10.97188039
50CDK180.95750525
51RAF10.94150072
52CSNK1G30.93109748
53BCR0.90117578
54SGK2230.87749193
55SGK4940.87749193
56CDK140.87623260
57TRIM280.87225189
58FGR0.87107926
59CDK150.87085812
60BMPR1B0.86497886
61CSNK1A1L0.85104396
62UHMK10.84652541
63MAP3K20.83230629
64SGK20.82713105
65CAMKK20.80197794
66AKT30.79060283
67INSRR0.77383056
68STK380.77169915
69CDK11A0.74774242
70DYRK1A0.71530919
71TYRO30.71330300
72SGK10.71218581
73CAMK40.68695963
74CSNK1G20.65728319
75CAMK10.65393207
76CCNB10.61871741
77MAPK150.61693277
78BRAF0.60492037
79CSNK1A10.59672111
80MAP3K60.59583675
81LATS20.59226927
82STK110.58559777
83RET0.56037949
84PAK30.55174277
85PHKG20.54872002
86PHKG10.54872002
87GRK70.53836150
88PDK10.53284462
89PRKCE0.53019927
90SGK30.51137895
91WNK30.50812863
92PINK10.50625809
93MARK20.50508313
94PDPK10.49667506
95EPHA30.48963761
96ADRBK20.48392412
97CAMK2D0.47213236
98PRKCH0.45920334
99MKNK10.45895517
100FER0.45367351
101PRKCZ0.45290457
102MAP3K10.43357408
103TNK20.43293339
104ERBB20.43266977
105CAMK2G0.43171101
106CSNK1D0.42747773
107MAP2K10.42323199
108RPS6KA30.39599509
109FYN0.38501404
110BCKDK0.37471469
111BRSK10.37086030
112PRKCA0.36641389
113GRK60.35324490
114ACVR1B0.35286377
115PRKG10.35201341
116NUAK10.34887864
117ADRBK10.33817796
118TAOK20.32793290
119TSSK60.32314478
120ERBB30.31468226
121MAPK80.31236165
122DAPK30.31159544
123PRKCB0.31016857
124MAPK100.30431120
125PRKACA0.28685477
126PLK30.28475044
127CSNK1E0.28374937
128NEK60.27857074
129ROCK20.27794041
130PRKD20.27619002
131RPS6KA20.26949398
132ZAK0.26460488
133PRKACB0.25875403

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.28819600
2Synaptic vesicle cycle_Homo sapiens_hsa047213.17453355
3Long-term potentiation_Homo sapiens_hsa047202.97064260
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87012105
5Amphetamine addiction_Homo sapiens_hsa050312.85932709
6Circadian entrainment_Homo sapiens_hsa047132.81857269
7Olfactory transduction_Homo sapiens_hsa047402.76615814
8Morphine addiction_Homo sapiens_hsa050322.69246326
9Glutamatergic synapse_Homo sapiens_hsa047242.68956963
10GABAergic synapse_Homo sapiens_hsa047272.67442704
11Dopaminergic synapse_Homo sapiens_hsa047282.39753539
12Salivary secretion_Homo sapiens_hsa049702.18448090
13Collecting duct acid secretion_Homo sapiens_hsa049662.08585799
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95549322
15Taste transduction_Homo sapiens_hsa047421.95406975
16Cocaine addiction_Homo sapiens_hsa050301.92363278
17Renin secretion_Homo sapiens_hsa049241.89492219
18Serotonergic synapse_Homo sapiens_hsa047261.86561693
19Cholinergic synapse_Homo sapiens_hsa047251.82893466
20Insulin secretion_Homo sapiens_hsa049111.82525608
21Long-term depression_Homo sapiens_hsa047301.78338484
22Gastric acid secretion_Homo sapiens_hsa049711.77271050
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73549109
24Calcium signaling pathway_Homo sapiens_hsa040201.73373598
25Oxytocin signaling pathway_Homo sapiens_hsa049211.63135946
26Gap junction_Homo sapiens_hsa045401.45945726
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45776006
28GnRH signaling pathway_Homo sapiens_hsa049121.44772871
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35008659
30Vibrio cholerae infection_Homo sapiens_hsa051101.29001717
31cAMP signaling pathway_Homo sapiens_hsa040241.26531458
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26061277
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25845177
34Axon guidance_Homo sapiens_hsa043601.19833291
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15613259
36Glioma_Homo sapiens_hsa052141.09026815
37Estrogen signaling pathway_Homo sapiens_hsa049151.06760431
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06093058
39ErbB signaling pathway_Homo sapiens_hsa040121.04795814
40Melanogenesis_Homo sapiens_hsa049161.02784572
41Phototransduction_Homo sapiens_hsa047441.02538430
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02242370
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01909909
44Cardiac muscle contraction_Homo sapiens_hsa042600.98347243
45Oxidative phosphorylation_Homo sapiens_hsa001900.98001810
46Alzheimers disease_Homo sapiens_hsa050100.95881987
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95210673
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.90603570
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87962796
50Type II diabetes mellitus_Homo sapiens_hsa049300.87885751
51Oocyte meiosis_Homo sapiens_hsa041140.85940787
52Vitamin B6 metabolism_Homo sapiens_hsa007500.85698895
53Histidine metabolism_Homo sapiens_hsa003400.81083256
54Parkinsons disease_Homo sapiens_hsa050120.75141210
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74031576
56Pancreatic secretion_Homo sapiens_hsa049720.73832941
57Butanoate metabolism_Homo sapiens_hsa006500.72339271
58Dorso-ventral axis formation_Homo sapiens_hsa043200.70645422
59Hedgehog signaling pathway_Homo sapiens_hsa043400.70593899
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69809529
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69333300
62Choline metabolism in cancer_Homo sapiens_hsa052310.69207322
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.67359088
64Ether lipid metabolism_Homo sapiens_hsa005650.67007272
65MAPK signaling pathway_Homo sapiens_hsa040100.64914065
66Thyroid hormone synthesis_Homo sapiens_hsa049180.64226646
67VEGF signaling pathway_Homo sapiens_hsa043700.63810882
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62659358
69African trypanosomiasis_Homo sapiens_hsa051430.61529159
70beta-Alanine metabolism_Homo sapiens_hsa004100.61366616
71Nitrogen metabolism_Homo sapiens_hsa009100.60997034
72Ras signaling pathway_Homo sapiens_hsa040140.60609781
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60321660
74Alcoholism_Homo sapiens_hsa050340.59782585
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59268714
76Glucagon signaling pathway_Homo sapiens_hsa049220.57794195
77Bile secretion_Homo sapiens_hsa049760.56123151
78Rap1 signaling pathway_Homo sapiens_hsa040150.54398392
79Hippo signaling pathway_Homo sapiens_hsa043900.53429121
80Dilated cardiomyopathy_Homo sapiens_hsa054140.52989844
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50637774
82Huntingtons disease_Homo sapiens_hsa050160.49762171
83Basal cell carcinoma_Homo sapiens_hsa052170.49078863
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48839510
85Non-small cell lung cancer_Homo sapiens_hsa052230.48812353
86ABC transporters_Homo sapiens_hsa020100.47060375
87Tryptophan metabolism_Homo sapiens_hsa003800.45753044
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.45382636
89Regulation of autophagy_Homo sapiens_hsa041400.45112115
90Wnt signaling pathway_Homo sapiens_hsa043100.45029389
91Steroid biosynthesis_Homo sapiens_hsa001000.44920438
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44620157
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44289354
94Linoleic acid metabolism_Homo sapiens_hsa005910.43272757
95Mineral absorption_Homo sapiens_hsa049780.42654744
96Type I diabetes mellitus_Homo sapiens_hsa049400.42351315
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.41734913
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41584786
99Glycerolipid metabolism_Homo sapiens_hsa005610.39379120
100Prion diseases_Homo sapiens_hsa050200.39255293
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39215329
102Rheumatoid arthritis_Homo sapiens_hsa053230.38629620
103Inositol phosphate metabolism_Homo sapiens_hsa005620.38087515
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37080648
105Endometrial cancer_Homo sapiens_hsa052130.37008303
106Protein export_Homo sapiens_hsa030600.33725438
107Melanoma_Homo sapiens_hsa052180.33085654
108Renal cell carcinoma_Homo sapiens_hsa052110.32821041
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31715785
110Fatty acid biosynthesis_Homo sapiens_hsa000610.31607893
111Selenocompound metabolism_Homo sapiens_hsa004500.31297184
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30428820
113Arginine and proline metabolism_Homo sapiens_hsa003300.30091207
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29952790
115Circadian rhythm_Homo sapiens_hsa047100.29182274
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28430172
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27934288
118Insulin signaling pathway_Homo sapiens_hsa049100.26888711
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25648809
120Endocytosis_Homo sapiens_hsa041440.24718375
121mTOR signaling pathway_Homo sapiens_hsa041500.24147041
122Chemokine signaling pathway_Homo sapiens_hsa040620.23794760
123Ovarian steroidogenesis_Homo sapiens_hsa049130.23238961
124Colorectal cancer_Homo sapiens_hsa052100.22498474
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20280384

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