LMO7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.30954971
2sarcomere organization (GO:0045214)6.07524649
3bundle of His cell to Purkinje myocyte communication (GO:0086069)5.80479130
4cardiac myofibril assembly (GO:0055003)5.70073781
5negative regulation of potassium ion transmembrane transport (GO:1901380)5.51893256
6ventricular cardiac muscle cell action potential (GO:0086005)5.34068856
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.25774417
8regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.09088869
9cell communication involved in cardiac conduction (GO:0086065)4.89533312
10myofibril assembly (GO:0030239)4.83444821
11regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.66988388
12cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.66462597
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.60322420
14cardiac muscle contraction (GO:0060048)4.58231829
15cardiac muscle cell development (GO:0055013)4.42513399
16actomyosin structure organization (GO:0031032)4.38335398
17plasma membrane repair (GO:0001778)4.37099945
18muscle filament sliding (GO:0030049)4.33300572
19actin-myosin filament sliding (GO:0033275)4.33300572
20desmosome organization (GO:0002934)4.30523600
21skin morphogenesis (GO:0043589)4.25675600
22sequestering of extracellular ligand from receptor (GO:0035581)4.23419693
23regulation of cardioblast differentiation (GO:0051890)4.22837878
24collagen fibril organization (GO:0030199)4.22217107
25cell adhesion mediated by integrin (GO:0033627)4.17170974
26cardiac cell development (GO:0055006)4.16651377
27regulation of skeletal muscle contraction (GO:0014819)4.04842845
28regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.03837131
29endocardial cushion development (GO:0003197)4.03011469
30cell communication by electrical coupling (GO:0010644)4.01932018
31relaxation of cardiac muscle (GO:0055119)4.00968156
32actin-mediated cell contraction (GO:0070252)4.00524548
33cardiac muscle hypertrophy (GO:0003300)3.94023327
34regulation of actin filament-based movement (GO:1903115)3.92252690
35regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.88255941
36cardiac conduction (GO:0061337)3.80909765
37striated muscle hypertrophy (GO:0014897)3.73317444
38regulation of membrane repolarization (GO:0060306)3.72561248
39cardiac muscle cell action potential involved in contraction (GO:0086002)3.71931809
40regulation of sarcomere organization (GO:0060297)3.71633672
41cardiac muscle cell action potential (GO:0086001)3.69452309
42striated muscle contraction (GO:0006941)3.67546428
43regulation of heart rate by cardiac conduction (GO:0086091)3.65630036
44cardiac muscle tissue morphogenesis (GO:0055008)3.65061155
45heart trabecula formation (GO:0060347)3.60492374
46carnitine shuttle (GO:0006853)3.57807070
47tricarboxylic acid cycle (GO:0006099)3.57310721
48ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.56017143
49pericardium development (GO:0060039)3.55049195
50chemical homeostasis within a tissue (GO:0048875)3.54916151
51regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.54671485
52regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.47784387
53surfactant homeostasis (GO:0043129)3.46277713
54membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.44399475
55regulation of cell communication by electrical coupling (GO:0010649)3.43421362
56regulation of striated muscle contraction (GO:0006942)3.42924574
57regulation of relaxation of muscle (GO:1901077)3.42637915
58actin filament-based movement (GO:0030048)3.40616751
59sarcoplasmic reticulum calcium ion transport (GO:0070296)3.39369807
60chondrocyte proliferation (GO:0035988)3.38968104
61regulation of the force of heart contraction (GO:0002026)3.31240278
62muscle tissue morphogenesis (GO:0060415)3.31016055
63kidney mesenchyme development (GO:0072074)3.29396839
64positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.27699966
65regulation of integrin-mediated signaling pathway (GO:2001044)3.25452256
66cell migration involved in heart development (GO:0060973)3.25040522
67cell-substrate junction assembly (GO:0007044)3.24394462
68extracellular matrix assembly (GO:0085029)3.23695727
69negative regulation of fatty acid transport (GO:2000192)3.20640369
70endodermal cell differentiation (GO:0035987)3.20522351
71adult heart development (GO:0007512)3.18024227
72negative regulation of complement activation (GO:0045916)3.16827134
73fatty acid transmembrane transport (GO:1902001)3.16807261
74regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.16362060
75hypotonic response (GO:0006971)3.15854725
76muscle hypertrophy (GO:0014896)3.15457664
77hemidesmosome assembly (GO:0031581)3.14919815
78membrane repolarization during action potential (GO:0086011)3.11011262
79regulation of heart rate (GO:0002027)3.09771233
80substrate-dependent cell migration (GO:0006929)3.08646278
81regulation of cardiac muscle contraction (GO:0055117)3.07331372
82peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.05625100
83metanephric mesenchyme development (GO:0072075)3.01728540
84negative regulation of potassium ion transport (GO:0043267)2.97770677
85cardiac muscle hypertrophy in response to stress (GO:0014898)2.97173238
86muscle hypertrophy in response to stress (GO:0003299)2.97173238
87cardiac muscle adaptation (GO:0014887)2.97173238
88glomerular basement membrane development (GO:0032836)2.97172061
89regulation of cardiac muscle cell contraction (GO:0086004)2.96825977
90detection of calcium ion (GO:0005513)2.96259579
91regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.95945052
92extracellular fibril organization (GO:0043206)2.95633060
93regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.93762871
94endothelial cell morphogenesis (GO:0001886)2.92746712
95negative regulation of protein activation cascade (GO:2000258)2.92728357
96atrioventricular valve morphogenesis (GO:0003181)2.91112846
97regulation of heart contraction (GO:0008016)2.90738344
98membrane raft organization (GO:0031579)2.89298052
99retina vasculature morphogenesis in camera-type eye (GO:0061299)2.89231388
100cell-substrate adherens junction assembly (GO:0007045)2.89110900
101focal adhesion assembly (GO:0048041)2.89110900
102extracellular regulation of signal transduction (GO:1900115)2.88769036
103extracellular negative regulation of signal transduction (GO:1900116)2.88769036
104regulation of tight junction assembly (GO:2000810)2.87883570
105epithelial cell-cell adhesion (GO:0090136)2.86847252
106protein heterotrimerization (GO:0070208)2.81788825
107protein localization to endosome (GO:0036010)2.81699783
108positive regulation of cation channel activity (GO:2001259)2.79526929
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.78133413
110mesenchymal-epithelial cell signaling (GO:0060638)2.77474457
111regulation of acyl-CoA biosynthetic process (GO:0050812)2.76840952
112response to muscle activity (GO:0014850)2.75376446
113type B pancreatic cell proliferation (GO:0044342)2.74549516
114negative regulation of protein localization to cell surface (GO:2000009)2.73789415
115positive regulation of extracellular matrix organization (GO:1903055)2.73676617
116COPII vesicle coating (GO:0048208)2.71907914
117membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70470507
118regulation of calcium ion transmembrane transporter activity (GO:1901019)2.70279324
119regulation of calcium ion transmembrane transport (GO:1903169)2.70279324
120positive regulation of heart contraction (GO:0045823)2.70254702
121positive regulation of blood vessel endothelial cell migration (GO:0043536)2.69521623
122adherens junction assembly (GO:0034333)2.69163389
123bone trabecula formation (GO:0060346)2.68950619
124smooth muscle tissue development (GO:0048745)2.68042719
125barbed-end actin filament capping (GO:0051016)2.67957720
126relaxation of muscle (GO:0090075)2.66130529
127positive regulation of potassium ion transmembrane transport (GO:1901381)2.65266642
128fibril organization (GO:0097435)2.64388353
129carnitine transmembrane transport (GO:1902603)2.63587615
130negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.62582067
131regulation of transforming growth factor beta1 production (GO:0032908)2.62116250
132striated muscle cell development (GO:0055002)2.61630735
133regulation of potassium ion transmembrane transporter activity (GO:1901016)2.61401513
134cell migration involved in sprouting angiogenesis (GO:0002042)2.60905945
135striated muscle adaptation (GO:0014888)2.60777640
136positive regulation of osteoblast proliferation (GO:0033690)2.58523034
137regulation of potassium ion transmembrane transport (GO:1901379)2.58074098
138fibroblast migration (GO:0010761)2.57423374
139substrate adhesion-dependent cell spreading (GO:0034446)2.57405717
140virion attachment to host cell (GO:0019062)2.56172969
141adhesion of symbiont to host cell (GO:0044650)2.56172969
142negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.54794139
143carnitine transport (GO:0015879)2.54083120
144amino-acid betaine transport (GO:0015838)2.54083120
145positive regulation of endothelial cell apoptotic process (GO:2000353)2.54025209
146muscle contraction (GO:0006936)2.53872756
147negative regulation of stem cell proliferation (GO:2000647)2.51424847
148regulation of cofactor metabolic process (GO:0051193)2.49437867
149regulation of coenzyme metabolic process (GO:0051196)2.49437867
150regulation of transforming growth factor beta2 production (GO:0032909)2.49180474
151collagen metabolic process (GO:0032963)2.48318145
152actin filament depolymerization (GO:0030042)2.48054724
153striated muscle atrophy (GO:0014891)2.47309164
154basement membrane organization (GO:0071711)2.46240737
155muscle cell migration (GO:0014812)2.45901322
156protein localization to cell surface (GO:0034394)2.45876261
157negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45495211
158regulation of p38MAPK cascade (GO:1900744)2.44768347
159negative regulation of ion transmembrane transporter activity (GO:0032413)2.44574987
160cellular response to vitamin (GO:0071295)2.44411322
161protein targeting to Golgi (GO:0000042)2.43776229
162dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.43757151
163peptide cross-linking (GO:0018149)2.43738506
164vascular endothelial growth factor signaling pathway (GO:0038084)2.43081153
165negative regulation of humoral immune response (GO:0002921)2.42872833
166regulation of ATPase activity (GO:0043462)2.42658446
167glomerular visceral epithelial cell development (GO:0072015)2.40785432
168stress fiber assembly (GO:0043149)2.40715433
169apoptotic cell clearance (GO:0043277)2.40665776
170regulation of plasminogen activation (GO:0010755)2.40602621
171multicellular organismal macromolecule metabolic process (GO:0044259)2.40376777
172wound healing, spreading of epidermal cells (GO:0035313)2.39410304
173regulation of cardiac muscle cell differentiation (GO:2000725)2.39017673
174glomerular epithelial cell development (GO:0072310)2.38370866
175Golgi transport vesicle coating (GO:0048200)2.37744270
176COPI coating of Golgi vesicle (GO:0048205)2.37744270
177negative regulation of osteoblast proliferation (GO:0033689)2.35626812
178hippo signaling (GO:0035329)2.34704824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.94471380
2* EP300_21415370_ChIP-Seq_HL-1_Mouse2.94104888
3ESR1_20079471_ChIP-ChIP_T-47D_Human2.69487757
4EZH2_22144423_ChIP-Seq_EOC_Human2.42532853
5BRD4_25478319_ChIP-Seq_HGPS_Human2.31022514
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.29532280
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.16575368
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.16344969
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.12397507
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.10795994
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.02393695
12TBX20_22328084_ChIP-Seq_HEART_Mouse2.00561950
13TBX20_22080862_ChIP-Seq_HEART_Mouse2.00561950
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94314853
15TP53_18474530_ChIP-ChIP_U2OS_Human1.89005349
16CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.87842367
17WT1_19549856_ChIP-ChIP_CCG9911_Human1.87330590
18GATA1_22025678_ChIP-Seq_K562_Human1.81022050
19RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.80715407
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75746540
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74405260
22* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73275759
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.70115661
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.69704140
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.67903750
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62530628
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59850878
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55735000
29ZNF263_19887448_ChIP-Seq_K562_Human1.55121761
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.54961788
31* AHR_22903824_ChIP-Seq_MCF-7_Human1.52767699
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50566580
33* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49626716
34CDX2_20551321_ChIP-Seq_CACO-2_Human1.47819580
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.47399760
36DROSHA_22980978_ChIP-Seq_HELA_Human1.47250973
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45953071
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41236601
39ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38948005
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38889819
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38834369
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38834369
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38520496
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.37949468
45CLOCK_20551151_ChIP-Seq_293T_Human1.37921661
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36880508
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36748184
48JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34357722
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34235474
50SMAD3_21741376_ChIP-Seq_HESCs_Human1.33968826
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33954244
52* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32793842
53* ARNT_22903824_ChIP-Seq_MCF-7_Human1.31005082
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.30918407
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30474592
56TP53_16413492_ChIP-PET_HCT116_Human1.29973352
57MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.29511788
58SOX2_20726797_ChIP-Seq_SW620_Human1.29375083
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28735133
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.27675652
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26521613
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.24607200
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24133380
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23484251
65CJUN_26792858_Chip-Seq_BT549_Human1.23092636
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22344338
67* ISL1_27105846_Chip-Seq_CPCs_Mouse1.22294378
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21678236
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21534981
70* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21001151
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20499302
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19928542
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19709866
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17124480
75LXR_22158963_ChIP-Seq_LIVER_Mouse1.17046496
76RARB_27405468_Chip-Seq_BRAIN_Mouse1.15765598
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15217203
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14119146
79BCAT_22108803_ChIP-Seq_LS180_Human1.12862221
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.12738438
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12172522
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09816928
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07868194
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07634997
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.06906602
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.06374002
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06306911
88* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06191670
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06126419
90* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06002563
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05833157
92SMAD4_21741376_ChIP-Seq_HESCs_Human1.05605801
93JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05028358
94* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04724086
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04364461
96* GATA4_25053715_ChIP-Seq_YYC3_Human1.04350652
97* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03882859
98* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03882859
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01449232
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.00585493
101KDM2B_26808549_Chip-Seq_K562_Human0.99601869
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97804398
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97741953
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97592482
105RNF2_27304074_Chip-Seq_ESCs_Mouse0.97486640
106EZH2_27304074_Chip-Seq_ESCs_Mouse0.96476754
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96427439
108* TP63_23658742_ChIP-Seq_EP156T_Human0.96355254
109SMAD4_21799915_ChIP-Seq_A2780_Human0.95985765
110* KLF5_25053715_ChIP-Seq_YYC3_Human0.95627328
111* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95534834
112SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95178051
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95124323
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95124323
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94745540
116RXR_22108803_ChIP-Seq_LS180_Human0.94297333
117P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94170690
118TP53_23651856_ChIP-Seq_MEFs_Mouse0.94035045
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.93979481
120RACK7_27058665_Chip-Seq_MCF-7_Human0.93662011
121* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92472487
122SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91795353
123EED_16625203_ChIP-ChIP_MESCs_Mouse0.90839926
124* GATA6_25053715_ChIP-Seq_YYC3_Human0.90275415
125ZNF274_21170338_ChIP-Seq_K562_Hela0.89972139
126YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89493128
127* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89304213
128SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88900475
129* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88580463
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88173522
131RXR_22158963_ChIP-Seq_LIVER_Mouse0.84746634
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81779192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.37193292
2MP0002837_dystrophic_cardiac_calcinosis5.15415391
3MP0004084_abnormal_cardiac_muscle4.85282917
4MP0004215_abnormal_myocardial_fiber3.99098222
5MP0000751_myopathy3.97461080
6MP0005503_abnormal_tendon_morphology3.52304356
7MP0004036_abnormal_muscle_relaxation3.50903517
8MP0003646_muscle_fatigue3.26427124
9MP0005330_cardiomyopathy3.19929266
10MP0003279_aneurysm3.17024358
11MP0000749_muscle_degeneration2.87555373
12MP0010234_abnormal_vibrissa_follicle2.76473980
13MP0002972_abnormal_cardiac_muscle2.71860515
14* MP0004087_abnormal_muscle_fiber2.53327704
15MP0003137_abnormal_impulse_conducting2.51225782
16MP0004484_altered_response_of2.47139758
17MP0008775_abnormal_heart_ventricle2.39345296
18MP0005620_abnormal_muscle_contractility2.37348723
19MP0001542_abnormal_bone_strength2.27381346
20MP0006138_congestive_heart_failure2.23183115
21MP0010630_abnormal_cardiac_muscle2.18831531
22MP0004085_abnormal_heartbeat2.15646538
23MP0010352_gastrointestinal_tract_polyps2.15123633
24MP0001544_abnormal_cardiovascular_syste2.15059615
25MP0005385_cardiovascular_system_phenoty2.15059615
26MP0005257_abnormal_intraocular_pressure1.99100775
27MP0005023_abnormal_wound_healing1.96157331
28MP0003828_pulmonary_edema1.93624959
29MP0000750_abnormal_muscle_regeneration1.93398455
30MP0009780_abnormal_chondrocyte_physiolo1.89993144
31MP0010368_abnormal_lymphatic_system1.89816924
32MP0004130_abnormal_muscle_cell1.86677326
33MP0004145_abnormal_muscle_electrophysio1.85668896
34MP0002822_catalepsy1.84058271
35MP0002106_abnormal_muscle_physiology1.79518468
36MP0004043_abnormal_pH_regulation1.79063709
37MP0002108_abnormal_muscle_morphology1.77126018
38MP0002269_muscular_atrophy1.75959272
39MP0003950_abnormal_plasma_membrane1.71154148
40MP0002234_abnormal_pharynx_morphology1.59492974
41MP0003705_abnormal_hypodermis_morpholog1.59090963
42MP0002060_abnormal_skin_morphology1.55985805
43MP0000747_muscle_weakness1.54671525
44MP0004272_abnormal_basement_membrane1.50639645
45MP0002896_abnormal_bone_mineralization1.49490469
46MP0001299_abnormal_eye_distance/1.46252868
47MP0005369_muscle_phenotype1.41468279
48MP0002909_abnormal_adrenal_gland1.40611898
49MP0004233_abnormal_muscle_weight1.39860084
50MP0003566_abnormal_cell_adhesion1.36306310
51MP0009384_cardiac_valve_regurgitation1.34949502
52MP0004510_myositis1.33285736
53MP0002127_abnormal_cardiovascular_syste1.31075103
54MP0003941_abnormal_skin_development1.29198335
55MP0009250_abnormal_appendicular_skeleto1.28031597
56* MP0000759_abnormal_skeletal_muscle1.24784897
57MP0000537_abnormal_urethra_morphology1.22902482
58MP0001765_abnormal_ion_homeostasis1.20433957
59MP0005508_abnormal_skeleton_morphology1.19054750
60MP0000534_abnormal_ureter_morphology1.18533111
61MP0004264_abnormal_extraembryonic_tissu1.17005783
62MP0010386_abnormal_urinary_bladder1.15841467
63MP0004185_abnormal_adipocyte_glucose1.15338272
64MP0005165_increased_susceptibility_to1.12266736
65MP0003221_abnormal_cardiomyocyte_apopto1.11569543
66MP0005167_abnormal_blood-brain_barrier1.10671499
67MP0005595_abnormal_vascular_smooth1.09808937
68MP0001958_emphysema1.08931580
69MP0005275_abnormal_skin_tensile1.07999400
70MP0005187_abnormal_penis_morphology1.07267881
71MP0000762_abnormal_tongue_morphology1.06122978
72MP0004859_abnormal_synaptic_plasticity1.05709148
73MP0002168_other_aberrant_phenotype1.04771151
74MP0001243_abnormal_dermal_layer1.04035843
75MP0008961_abnormal_basal_metabolism1.03998144
76MP0005666_abnormal_adipose_tissue1.00216570
77MP0000230_abnormal_systemic_arterial0.99769065
78MP0010030_abnormal_orbit_morphology0.99731356
79MP0000266_abnormal_heart_morphology0.96578742
80MP0005164_abnormal_response_to0.95200646
81MP0002295_abnormal_pulmonary_circulatio0.94999951
82MP0005085_abnormal_gallbladder_physiolo0.94660201
83MP0005409_darkened_coat_color0.92666369
84MP0000462_abnormal_digestive_system0.92176439
85MP0001666_abnormal_nutrient_absorption0.91788434
86MP0002796_impaired_skin_barrier0.91404169
87MP0003567_abnormal_fetal_cardiomyocyte0.91277269
88MP0003045_fibrosis0.90642099
89MP0000013_abnormal_adipose_tissue0.90144277
90MP0002332_abnormal_exercise_endurance0.89697165
91MP0005451_abnormal_body_composition0.88139358
92MP0004782_abnormal_surfactant_physiolog0.87922437
93MP0003300_gastrointestinal_ulcer0.87905566
94MP0001879_abnormal_lymphatic_vessel0.87563499
95MP0004134_abnormal_chest_morphology0.87540622
96MP0003191_abnormal_cellular_cholesterol0.86099948
97MP0004270_analgesia0.83954005
98MP0008004_abnormal_stomach_pH0.83060388
99MP0003868_abnormal_feces_composition0.81349822
100MP0001348_abnormal_lacrimal_gland0.79512830
101MP0003942_abnormal_urinary_system0.78079533
102MP0003091_abnormal_cell_migration0.76715659
103MP0005623_abnormal_meninges_morphology0.75362678
104MP0003385_abnormal_body_wall0.75214011
105MP0001661_extended_life_span0.75166997
106MP0005360_urolithiasis0.75025578
107MP0010678_abnormal_skin_adnexa0.74474104
108MP0005375_adipose_tissue_phenotype0.71460823
109MP0005388_respiratory_system_phenotype0.71358587
110MP0002133_abnormal_respiratory_system0.71358587
111MP0005083_abnormal_biliary_tract0.70741444
112MP0002115_abnormal_skeleton_extremities0.68129020
113MP0002128_abnormal_blood_circulation0.68098947
114MP0001756_abnormal_urination0.67622183
115MP0008875_abnormal_xenobiotic_pharmacok0.67514191
116MP0001614_abnormal_blood_vessel0.66865103
117MP0000767_abnormal_smooth_muscle0.66306798
118MP0003878_abnormal_ear_physiology0.66020801
119MP0005377_hearing/vestibular/ear_phenot0.66020801
120MP0000163_abnormal_cartilage_morphology0.65623365
121MP0003252_abnormal_bile_duct0.65322628
122MP0009840_abnormal_foam_cell0.63912980
123MP0004883_abnormal_blood_vessel0.63562808
124MP0002925_abnormal_cardiovascular_devel0.63103094
125MP0000579_abnormal_nail_morphology0.63063323
126MP0000003_abnormal_adipose_tissue0.62936778
127MP0000432_abnormal_head_morphology0.62743864
128MP0000467_abnormal_esophagus_morphology0.62038849
129MP0009643_abnormal_urine_homeostasis0.60883374
130MP0003115_abnormal_respiratory_system0.58026490
131MP0006054_spinal_hemorrhage0.57861995
132MP0002877_abnormal_melanocyte_morpholog0.57191377
133MP0000538_abnormal_urinary_bladder0.56897328
134MP0002998_abnormal_bone_remodeling0.56722622
135MP0000343_altered_response_to0.56067364
136MP0001849_ear_inflammation0.55523768
137MP0001177_atelectasis0.55458385
138MP0001664_abnormal_digestion0.54907186
139MP0006036_abnormal_mitochondrial_physio0.54892055
140MP0000733_abnormal_muscle_development0.53629593

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.36886857
2Right ventricular cardiomyopathy (HP:0011663)6.74742697
3Premature rupture of membranes (HP:0001788)6.15809398
4Protrusio acetabuli (HP:0003179)5.99107282
5Ventricular tachycardia (HP:0004756)5.97324560
6Syncope (HP:0001279)5.38813455
7Atrial fibrillation (HP:0005110)5.31338513
8Aortic aneurysm (HP:0004942)5.15772986
9Primary atrial arrhythmia (HP:0001692)4.99077777
10Aortic dissection (HP:0002647)4.86841518
11Supraventricular tachycardia (HP:0004755)4.73475399
12Calf muscle hypertrophy (HP:0008981)4.71773258
13Supraventricular arrhythmia (HP:0005115)4.67550766
14Exercise-induced myalgia (HP:0003738)4.53942880
15Hyporeflexia of lower limbs (HP:0002600)4.47072095
16Bundle branch block (HP:0011710)4.43930438
17Prolonged QT interval (HP:0001657)4.43152793
18Ventricular fibrillation (HP:0001663)4.40198907
19Vascular tortuosity (HP:0004948)4.34939364
20Muscle fiber splitting (HP:0003555)4.33480928
21Ventricular arrhythmia (HP:0004308)4.32045155
22Abnormality of the calf musculature (HP:0001430)4.31551752
23Muscle hypertrophy of the lower extremities (HP:0008968)4.20211190
24Lipoatrophy (HP:0100578)4.18781714
25Exercise-induced muscle cramps (HP:0003710)4.12547869
26Arterial tortuosity (HP:0005116)4.08625636
27Abnormality of the left ventricular outflow tract (HP:0011103)3.98578463
28Subaortic stenosis (HP:0001682)3.98578463
29Palpitations (HP:0001962)3.66808873
30Heart block (HP:0012722)3.62798837
31Nemaline bodies (HP:0003798)3.59927645
32Atrioventricular block (HP:0001678)3.52486803
33Dilated cardiomyopathy (HP:0001644)3.51863389
34Abnormal atrioventricular conduction (HP:0005150)3.49253891
35Soft skin (HP:0000977)3.39030035
36Myoglobinuria (HP:0002913)3.35120498
37Increased connective tissue (HP:0009025)3.33156149
38EMG: myopathic abnormalities (HP:0003458)3.22738427
39Round ear (HP:0100830)3.21039988
40Spinal rigidity (HP:0003306)3.19692206
41Mildly elevated creatine phosphokinase (HP:0008180)3.15778220
42Abnormal EKG (HP:0003115)3.14784867
43Asymmetric septal hypertrophy (HP:0001670)3.13417585
44Wormian bones (HP:0002645)3.13019700
45Fragile skin (HP:0001030)3.03000785
46Cardiovascular calcification (HP:0011915)2.96986880
47Difficulty running (HP:0009046)2.96852394
48Spondylolisthesis (HP:0003302)2.91579259
49Bladder diverticulum (HP:0000015)2.90989973
50Ankle contracture (HP:0006466)2.85351018
51Difficulty climbing stairs (HP:0003551)2.82362955
52Neonatal short-limb short stature (HP:0008921)2.81303884
53Follicular hyperkeratosis (HP:0007502)2.78781377
54Hyperactive renin-angiotensin system (HP:0000841)2.75909189
55Overgrowth (HP:0001548)2.73517825
56Dilatation of the ascending aorta (HP:0005111)2.72211473
57Type 1 muscle fiber predominance (HP:0003803)2.70525101
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.70524052
59Osteolytic defects of the hand bones (HP:0009699)2.70524052
60Mitral stenosis (HP:0001718)2.70305059
61Abnormality of dentin (HP:0010299)2.69812043
62Cervical subluxation (HP:0003308)2.60020590
63Mitral valve prolapse (HP:0001634)2.59602050
64Shallow orbits (HP:0000586)2.53396173
65Popliteal pterygium (HP:0009756)2.49487097
66Aortic regurgitation (HP:0001659)2.43590070
67Cerebral aneurysm (HP:0004944)2.43044514
68Aplasia of the musculature (HP:0100854)2.42640950
69Palmoplantar keratoderma (HP:0000982)2.39790459
70Ketoacidosis (HP:0001993)2.37502245
71Peritonitis (HP:0002586)2.35060767
72Elbow flexion contracture (HP:0002987)2.34446771
73Hypoplastic ischia (HP:0003175)2.32202188
74Genu recurvatum (HP:0002816)2.31262718
75Myotonia (HP:0002486)2.29537260
76Broad metatarsal (HP:0001783)2.28701303
77Neck muscle weakness (HP:0000467)2.28673181
78Abnormality of the acetabulum (HP:0003170)2.26523931
79Ulnar deviation of the wrist (HP:0003049)2.26317294
80Blue sclerae (HP:0000592)2.25550486
81Sudden cardiac death (HP:0001645)2.24103925
82Dysmetric saccades (HP:0000641)2.23140302
83Increased variability in muscle fiber diameter (HP:0003557)2.22703223
84Rhabdomyolysis (HP:0003201)2.21689343
85Hyperkalemia (HP:0002153)2.20990850
86Congenital malformation of the right heart (HP:0011723)2.20933151
87Double outlet right ventricle (HP:0001719)2.20933151
88Slender build (HP:0001533)2.20616856
89Distal arthrogryposis (HP:0005684)2.16927837
90Distal lower limb muscle weakness (HP:0009053)2.16088307
91Hypoglycemic coma (HP:0001325)2.14344301
92Ulnar bowing (HP:0003031)2.13889038
93Short nail (HP:0001799)2.12780770
94Mitral regurgitation (HP:0001653)2.12456131
95Hyperextensible skin (HP:0000974)2.11140217
96Vascular calcification (HP:0004934)2.10088404
97Reduced subcutaneous adipose tissue (HP:0003758)2.08642205
98Abnormal delivery (HP:0001787)2.08371694
99Left ventricular hypertrophy (HP:0001712)2.06061658
100Joint laxity (HP:0001388)2.03709911
101Distal lower limb amyotrophy (HP:0008944)2.03387619
102Hyperglycemia (HP:0003074)2.01931105
103Bowel diverticulosis (HP:0005222)2.00760323
104Abnormality of the ischium (HP:0003174)1.99467169
105Testicular atrophy (HP:0000029)1.98177899
106EMG: neuropathic changes (HP:0003445)1.98022453
107Gout (HP:0001997)1.97999909
108Limited hip movement (HP:0008800)1.97747503
109Decreased circulating renin level (HP:0003351)1.97043102
110Vertebral compression fractures (HP:0002953)1.97009796
111Scapular winging (HP:0003691)1.96417456
112Interstitial pulmonary disease (HP:0006530)1.94886475
113Abnormality of skeletal muscle fiber size (HP:0012084)1.94397562
114Striae distensae (HP:0001065)1.94318811
115Hypoplasia of the iris (HP:0007676)1.92590059
116Abnormality of carpal bone ossification (HP:0006257)1.90873042
117Aneurysm (HP:0002617)1.90174217
118Knee flexion contracture (HP:0006380)1.88529348
119Limb-girdle muscle atrophy (HP:0003797)1.88403884
120Hip contracture (HP:0003273)1.86910698
121Polycythemia (HP:0001901)1.86359830
122Wide anterior fontanel (HP:0000260)1.86345316
123Camptodactyly of toe (HP:0001836)1.85048674
124Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82706847
125Gowers sign (HP:0003391)1.82390125
126Biconcave vertebral bodies (HP:0004586)1.79538546
127Mild short stature (HP:0003502)1.79023156
128Thin bony cortex (HP:0002753)1.78220558
129Atrophic scars (HP:0001075)1.77551624
130Proximal amyotrophy (HP:0007126)1.77360209
131Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76388173
132Milia (HP:0001056)1.76313290
133Calcaneovalgus deformity (HP:0001848)1.75083556
134Abnormality of chloride homeostasis (HP:0011422)1.74529556
135Lymphangioma (HP:0100764)1.74065341
136Generalized muscle weakness (HP:0003324)1.73475332
137Breech presentation (HP:0001623)1.73041551
138Onycholysis (HP:0001806)1.72909675
139Conjunctival hamartoma (HP:0100780)1.72857246
140Ovoid vertebral bodies (HP:0003300)1.72499805
141Rectal prolapse (HP:0002035)1.71484580
142Lower limb amyotrophy (HP:0007210)1.70893654
143Visceral angiomatosis (HP:0100761)1.69974430
144Aortic valve stenosis (HP:0001650)1.69440201
145Deformed tarsal bones (HP:0008119)1.68795947
146Muscle fiber inclusion bodies (HP:0100299)1.68179081
147Osteoarthritis (HP:0002758)1.67878212
148Joint stiffness (HP:0001387)1.67793690
149Hamartoma of the eye (HP:0010568)1.67457777
150Ileus (HP:0002595)1.66580241
151Hyperaldosteronism (HP:0000859)1.64786358
152Facial diplegia (HP:0001349)1.64507830
153Congestive heart failure (HP:0001635)1.64506781
154Muscular dystrophy (HP:0003560)1.63262709
155Insulin-resistant diabetes mellitus (HP:0000831)1.58712175
156Abnormality of renin-angiotensin system (HP:0000847)1.58600890
157Neonatal death (HP:0003811)1.57681380
158Abnormality of the foot musculature (HP:0001436)1.56759135
159Hemangiomatosis (HP:0007461)1.56742867
160Hyperinsulinemic hypoglycemia (HP:0000825)1.56684596
161Rapidly progressive (HP:0003678)1.56284937
162Abnormality of fatty-acid metabolism (HP:0004359)1.55103020
163Muscle stiffness (HP:0003552)1.52047134
164Bradycardia (HP:0001662)1.51689781
165Cavernous hemangioma (HP:0001048)1.51158485
166Centrally nucleated skeletal muscle fibers (HP:0003687)1.50962883
167Ketosis (HP:0001946)1.49266639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK23.65984882
2TTN3.30972555
3NEK92.93358721
4DMPK2.89875687
5OBSCN2.85149628
6MYLK2.73632714
7PKN22.26724146
8TRIB32.19221026
9PIK3CA2.18229695
10LATS12.17184323
11PHKG12.07738342
12PHKG22.07738342
13PDK32.07265895
14PDK42.07265895
15TIE12.06150396
16LIMK11.99835806
17EPHA41.96141066
18FRK1.86699104
19KSR21.86368123
20STK241.78409085
21PIK3CG1.77976440
22RIPK11.73782164
23MAP3K21.72079659
24PAK21.62237549
25EPHA21.59676521
26WNK41.57306457
27PDK21.54999067
28AKT31.51250550
29FER1.46847737
30STK391.45360625
31TESK11.44865101
32MST1R1.42936068
33PAK31.36171451
34TAOK11.32927343
35MST41.31414216
36MAP3K91.28125944
37PAK41.25291517
38MAP3K71.24406040
39STK38L1.23995355
40MAP3K121.20897778
41EPHB21.17272206
42NEK11.16489949
43PDGFRA1.13539139
44ICK1.12242326
45MUSK1.10385912
46PRKD31.07952965
47INSRR1.07788874
48PRKD11.07617167
49CAMK2D1.07404460
50STK381.04933042
51MAP3K31.04222019
52TRPM71.02536842
53MAPKAPK31.00216998
54LATS20.99771694
55FGFR40.98346622
56PRKD20.98009672
57MELK0.97655737
58CDK120.95948629
59MOS0.95086887
60ROCK10.94971588
61CDC42BPA0.90828226
62PTK60.88163214
63PRKAA20.87623679
64ILK0.84965089
65ERBB40.84799187
66MTOR0.83984435
67PINK10.83681071
68DDR20.78106738
69MAP2K10.77323391
70PTK2B0.75464607
71FGFR30.75076418
72MAPK70.73987887
73NTRK30.73867812
74PTK20.73695439
75DAPK20.73319144
76MAP3K10.72970442
77TAOK30.72967596
78MET0.72008576
79PRKAA10.71238312
80PDPK10.69898253
81CAMK2A0.69256939
82MARK20.69236226
83RET0.68989732
84CDK80.66249173
85NUAK10.65238006
86WNK10.63650120
87STK30.62469582
88TGFBR20.61342945
89LRRK20.60843970
90PRKG20.60318355
91PRKCE0.60045912
92MAP3K50.60014208
93BCKDK0.59788531
94KSR10.59188732
95CAMK10.57252229
96EPHB10.56868872
97SGK30.56365245
98CAMK2G0.55881159
99MAP3K60.55072680
100RPS6KA20.54203137
101PAK60.54195697
102NME10.53230124
103ERBB30.53097548
104SIK10.51755385
105ROCK20.50441937
106PDGFRB0.50166035
107OXSR10.47845300
108MAPK110.46456458
109PDK10.46401470
110NTRK10.46371612
111DAPK30.45733575
112GSK3A0.45653639
113JAK10.43722824
114CAMKK10.43288315
115FLT30.43055621
116GRK70.42850618
117CAMK2B0.41156213
118ERN10.40346731
119FGFR20.40308409
120ZAK0.40161269
121BRSK20.39728387
122SGK20.39249925
123CAMK40.38601144
124MAPK120.38520490
125ABL20.38019674
126EEF2K0.37929555
127RAF10.37734566
128MAP3K40.36974579
129SGK10.36605880
130ADRBK10.34392738
131MAP3K130.32129906
132SCYL20.31581482
133PRKG10.22979552
134AKT20.22559123

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.38747068
2Dilated cardiomyopathy_Homo sapiens_hsa054143.03903415
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.95805370
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.53741521
5Cardiac muscle contraction_Homo sapiens_hsa042602.47262892
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.45548478
7Fatty acid degradation_Homo sapiens_hsa000711.92599739
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78857757
9Propanoate metabolism_Homo sapiens_hsa006401.72827655
10Tight junction_Homo sapiens_hsa045301.56348204
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54091750
12Complement and coagulation cascades_Homo sapiens_hsa046101.52214283
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50694537
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49308260
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42838097
16Gastric acid secretion_Homo sapiens_hsa049711.33301224
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32877747
18Small cell lung cancer_Homo sapiens_hsa052221.27257662
19cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27247849
20* Adherens junction_Homo sapiens_hsa045201.26939971
21TGF-beta signaling pathway_Homo sapiens_hsa043501.26478684
22Focal adhesion_Homo sapiens_hsa045101.21452751
23ECM-receptor interaction_Homo sapiens_hsa045121.21124883
24Renin secretion_Homo sapiens_hsa049241.20931481
25Mineral absorption_Homo sapiens_hsa049781.19408536
26Fatty acid metabolism_Homo sapiens_hsa012121.18759279
27Oxytocin signaling pathway_Homo sapiens_hsa049211.17380101
28Carbon metabolism_Homo sapiens_hsa012001.14819221
29Sulfur metabolism_Homo sapiens_hsa009201.13462037
30Circadian entrainment_Homo sapiens_hsa047131.13265189
31Insulin secretion_Homo sapiens_hsa049111.11135197
32Salivary secretion_Homo sapiens_hsa049701.08985243
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.08188376
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07548946
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.05405051
36Long-term potentiation_Homo sapiens_hsa047201.04809771
37Bile secretion_Homo sapiens_hsa049761.02043253
38Calcium signaling pathway_Homo sapiens_hsa040201.00549655
39Type II diabetes mellitus_Homo sapiens_hsa049300.99366675
40Starch and sucrose metabolism_Homo sapiens_hsa005000.99324389
41Insulin resistance_Homo sapiens_hsa049310.97501125
42Glycosaminoglycan degradation_Homo sapiens_hsa005310.97292009
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96685904
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95887998
45Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95730053
46GnRH signaling pathway_Homo sapiens_hsa049120.95464673
47Histidine metabolism_Homo sapiens_hsa003400.94600290
48Butanoate metabolism_Homo sapiens_hsa006500.93340916
49Pyruvate metabolism_Homo sapiens_hsa006200.91570635
50Phenylalanine metabolism_Homo sapiens_hsa003600.90202277
51Glucagon signaling pathway_Homo sapiens_hsa049220.90183930
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88436060
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88362349
54cAMP signaling pathway_Homo sapiens_hsa040240.87982447
55Amphetamine addiction_Homo sapiens_hsa050310.86432609
56Renin-angiotensin system_Homo sapiens_hsa046140.84691822
57Arginine biosynthesis_Homo sapiens_hsa002200.84112492
58MicroRNAs in cancer_Homo sapiens_hsa052060.84005998
59Melanoma_Homo sapiens_hsa052180.82355581
60PPAR signaling pathway_Homo sapiens_hsa033200.82340320
61Dorso-ventral axis formation_Homo sapiens_hsa043200.82133936
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81821130
63Protein digestion and absorption_Homo sapiens_hsa049740.81763740
64Amoebiasis_Homo sapiens_hsa051460.81568644
65Circadian rhythm_Homo sapiens_hsa047100.81323331
66Viral myocarditis_Homo sapiens_hsa054160.81150950
67Olfactory transduction_Homo sapiens_hsa047400.79542039
68Tryptophan metabolism_Homo sapiens_hsa003800.78198814
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77145132
70Gap junction_Homo sapiens_hsa045400.76773289
71Fat digestion and absorption_Homo sapiens_hsa049750.76467268
72Insulin signaling pathway_Homo sapiens_hsa049100.75628970
73Thyroid hormone synthesis_Homo sapiens_hsa049180.74851072
74Alzheimers disease_Homo sapiens_hsa050100.73917204
75Cholinergic synapse_Homo sapiens_hsa047250.73489069
76Hedgehog signaling pathway_Homo sapiens_hsa043400.73415172
77Pancreatic secretion_Homo sapiens_hsa049720.73321117
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.72530011
79Taste transduction_Homo sapiens_hsa047420.71241893
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70533905
81Pathways in cancer_Homo sapiens_hsa052000.70155132
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.69178351
83Bladder cancer_Homo sapiens_hsa052190.68347844
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68286563
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68173485
86Sphingolipid metabolism_Homo sapiens_hsa006000.67601844
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67345450
88Platelet activation_Homo sapiens_hsa046110.66036150
89Estrogen signaling pathway_Homo sapiens_hsa049150.65732084
90Proteoglycans in cancer_Homo sapiens_hsa052050.64881938
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64775685
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64615562
93Endometrial cancer_Homo sapiens_hsa052130.64333140
94Dopaminergic synapse_Homo sapiens_hsa047280.63912423
95AMPK signaling pathway_Homo sapiens_hsa041520.62299246
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60957780
97Lysine degradation_Homo sapiens_hsa003100.60112197
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.59956429
99VEGF signaling pathway_Homo sapiens_hsa043700.59761451
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59724319
101Wnt signaling pathway_Homo sapiens_hsa043100.59704313
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59112141
103Chronic myeloid leukemia_Homo sapiens_hsa052200.59046604
104Hippo signaling pathway_Homo sapiens_hsa043900.59028580
105Glutamatergic synapse_Homo sapiens_hsa047240.58663385
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58403049
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.57442054
108Tyrosine metabolism_Homo sapiens_hsa003500.57088326
109Endocytosis_Homo sapiens_hsa041440.57086586
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56634375
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56128898
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56092511
113Rap1 signaling pathway_Homo sapiens_hsa040150.55915020
114Melanogenesis_Homo sapiens_hsa049160.55799847
115Renal cell carcinoma_Homo sapiens_hsa052110.55041515
116Pancreatic cancer_Homo sapiens_hsa052120.54844806
117Parkinsons disease_Homo sapiens_hsa050120.54783789
118Galactose metabolism_Homo sapiens_hsa000520.54604319
119Ovarian steroidogenesis_Homo sapiens_hsa049130.54130312
120Pertussis_Homo sapiens_hsa051330.54011650
121mTOR signaling pathway_Homo sapiens_hsa041500.54004278
122Chemical carcinogenesis_Homo sapiens_hsa052040.53814034
123Basal cell carcinoma_Homo sapiens_hsa052170.53319103
124ABC transporters_Homo sapiens_hsa020100.53132822
125Prostate cancer_Homo sapiens_hsa052150.52958850
126Cocaine addiction_Homo sapiens_hsa050300.52656429
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52570721
128Oxidative phosphorylation_Homo sapiens_hsa001900.52143971
129HIF-1 signaling pathway_Homo sapiens_hsa040660.51872676
130Glioma_Homo sapiens_hsa052140.51402077
131Other glycan degradation_Homo sapiens_hsa005110.51251737
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51231007
133Axon guidance_Homo sapiens_hsa043600.49684801
134beta-Alanine metabolism_Homo sapiens_hsa004100.49590612
135FoxO signaling pathway_Homo sapiens_hsa040680.47927645
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47746002
137Thyroid cancer_Homo sapiens_hsa052160.46246127
138Retinol metabolism_Homo sapiens_hsa008300.44094298
139Fructose and mannose metabolism_Homo sapiens_hsa000510.40313704

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