LMO7DN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of macrophage activation (GO:0043032)6.14499168
2muscle cell cellular homeostasis (GO:0046716)5.74040390
3response to muscle activity (GO:0014850)5.63174334
4regulation of integrin-mediated signaling pathway (GO:2001044)4.99436340
5negative regulation of axon extension involved in axon guidance (GO:0048843)4.62817934
6positive regulation of chemokine secretion (GO:0090197)4.52266293
7endocrine hormone secretion (GO:0060986)4.48546386
8positive regulation of catecholamine secretion (GO:0033605)4.43291653
9regulation of gonadotropin secretion (GO:0032276)4.34635028
10mesenchymal-epithelial cell signaling (GO:0060638)4.27714691
11negative regulation of axon guidance (GO:1902668)4.25445242
12anterior/posterior axis specification, embryo (GO:0008595)4.24533293
13positive regulation of natural killer cell differentiation (GO:0032825)4.20553104
14cellular response to zinc ion (GO:0071294)4.19864768
15arginine catabolic process (GO:0006527)4.11891446
16regulation of chemokine secretion (GO:0090196)3.76901937
17positive regulation of protein kinase C signaling (GO:0090037)3.64777693
18multicellular organismal movement (GO:0050879)3.61874597
19musculoskeletal movement (GO:0050881)3.61874597
20negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.61640713
21regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.53694528
22vagina development (GO:0060068)3.50570550
23regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.49749093
24negative regulation of macrophage differentiation (GO:0045650)3.48691117
25regulation of hippo signaling (GO:0035330)3.48147116
26female genitalia development (GO:0030540)3.39019901
27fibroblast migration (GO:0010761)3.38667319
28myofibril assembly (GO:0030239)3.27417418
29regulation of natural killer cell differentiation (GO:0032823)3.25374619
30positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.23956751
31G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21703983
32positive regulation of protein autophosphorylation (GO:0031954)3.18777297
33muscle cell fate commitment (GO:0042693)3.12938802
34activation of protein kinase B activity (GO:0032148)3.08417256
35lymphangiogenesis (GO:0001946)3.03548226
36cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.03096906
37myoblast migration (GO:0051451)3.02996492
38ovulation cycle (GO:0042698)3.02597271
39cellular response to interferon-alpha (GO:0035457)3.01032730
40negative regulation of stem cell proliferation (GO:2000647)3.00262820
41neural crest cell development (GO:0014032)2.99632773
42ADP metabolic process (GO:0046031)2.97304492
43neuromuscular synaptic transmission (GO:0007274)2.97303543
44negative regulation of interferon-gamma production (GO:0032689)2.94875377
45sulfation (GO:0051923)2.91602913
46melanin biosynthetic process (GO:0042438)2.91453995
47peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.89862349
48regulation of axon extension involved in axon guidance (GO:0048841)2.87833982
49cellular response to sterol (GO:0036315)2.87266128
50regulation of axon guidance (GO:1902667)2.84237999
51mesodermal cell differentiation (GO:0048333)2.83124986
52plasma membrane repair (GO:0001778)2.82078235
53cell migration involved in heart development (GO:0060973)2.80087191
54retinal rod cell development (GO:0046548)2.79397143
55regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.79372064
56substrate adhesion-dependent cell spreading (GO:0034446)2.79157379
57uterus development (GO:0060065)2.78392355
58behavioral response to nicotine (GO:0035095)2.78333974
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77732039
60positive regulation of actin filament depolymerization (GO:0030836)2.77466222
61platelet dense granule organization (GO:0060155)2.76210491
62regulation of organ formation (GO:0003156)2.76131022
63regulation of interleukin-5 production (GO:0032674)2.74618006
64negative regulation of nitric-oxide synthase activity (GO:0051001)2.71728821
65negative regulation of chondrocyte differentiation (GO:0032331)2.70822936
66oligosaccharide biosynthetic process (GO:0009312)2.70580659
67regulation of macrophage activation (GO:0043030)2.68796789
68secondary metabolite biosynthetic process (GO:0044550)2.67111492
69positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.66763815
70negative regulation of synaptic transmission, GABAergic (GO:0032229)2.65293731
71negative regulation of complement activation (GO:0045916)2.64499296
72smooth muscle tissue development (GO:0048745)2.63129744
73coenzyme catabolic process (GO:0009109)2.62021739
74activin receptor signaling pathway (GO:0032924)2.61452964
75dermatan sulfate biosynthetic process (GO:0030208)2.61412222
76DNA integration (GO:0015074)2.60787606
77multicellular organism reproduction (GO:0032504)2.59963932
78eyelid development in camera-type eye (GO:0061029)2.59156429
79cornea development in camera-type eye (GO:0061303)2.58304660
80mesenchymal cell development (GO:0014031)2.58270853
81behavioral response to ethanol (GO:0048149)2.53391311
82melanin metabolic process (GO:0006582)2.52287601
83protein localization to cell surface (GO:0034394)2.51548790
84regulation of skeletal muscle contraction (GO:0014819)2.49806740
85regulation of keratinocyte proliferation (GO:0010837)2.49136987
86negative regulation of striated muscle cell apoptotic process (GO:0010664)2.48506116
87cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.47457507
88neuronal action potential (GO:0019228)2.46701401
89regulation of oxidative stress-induced neuron death (GO:1903203)2.46435777
90ovulation from ovarian follicle (GO:0001542)2.45709295
91positive regulation of fatty acid oxidation (GO:0046321)2.43676799
92sarcomere organization (GO:0045214)2.42271230
93kidney mesenchyme development (GO:0072074)2.40463492
94organ induction (GO:0001759)2.40047372
95glandular epithelial cell development (GO:0002068)2.39125480
96regulation of protein autophosphorylation (GO:0031952)2.36608442
97collagen fibril organization (GO:0030199)2.36025592
98AMP metabolic process (GO:0046033)2.34399779
99pigment cell differentiation (GO:0050931)2.31071552
100UDP-N-acetylglucosamine metabolic process (GO:0006047)2.30954814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.80222299
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.59742937
3GBX2_23144817_ChIP-Seq_PC3_Human3.16776748
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.14910420
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46686697
6ZNF274_21170338_ChIP-Seq_K562_Hela2.45160262
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44472137
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43690314
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.36009508
10CJUN_26792858_Chip-Seq_BT549_Human2.18622473
11PIAS1_25552417_ChIP-Seq_VCAP_Human2.13994902
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.09114164
13VDR_22108803_ChIP-Seq_LS180_Human1.96861080
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94934350
15BRD4_25478319_ChIP-Seq_HGPS_Human1.94537919
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89331012
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85406529
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.84412472
19ER_23166858_ChIP-Seq_MCF-7_Human1.82516939
20P300_19829295_ChIP-Seq_ESCs_Human1.80985937
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77242026
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.76678074
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75396644
24SMAD4_21799915_ChIP-Seq_A2780_Human1.68999036
25FUS_26573619_Chip-Seq_HEK293_Human1.67618880
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64890295
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.62169802
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60893091
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.57394044
30AR_21572438_ChIP-Seq_LNCaP_Human1.56751014
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.56535309
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55273348
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55273348
34STAT3_23295773_ChIP-Seq_U87_Human1.54723290
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54290067
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.53238702
37TP53_18474530_ChIP-ChIP_U2OS_Human1.52047875
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49391245
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49384762
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46171232
41CBP_20019798_ChIP-Seq_JUKART_Human1.46171232
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42378518
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42306526
44BCAT_22108803_ChIP-Seq_LS180_Human1.38682412
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38420158
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.37865473
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36325058
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.35482435
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34791491
50EWS_26573619_Chip-Seq_HEK293_Human1.31178233
51AHR_22903824_ChIP-Seq_MCF-7_Human1.30823905
52RXR_22108803_ChIP-Seq_LS180_Human1.30727865
53TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30146867
54TP53_16413492_ChIP-PET_HCT116_Human1.29512843
55CRX_20693478_ChIP-Seq_RETINA_Mouse1.28819814
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26941802
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.26550431
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26032112
59TCF4_22108803_ChIP-Seq_LS180_Human1.24871490
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24763990
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.24030172
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.23761202
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23047929
64AR_25329375_ChIP-Seq_VCAP_Human1.22522420
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22462183
66TCF4_23295773_ChIP-Seq_U87_Human1.20145384
67IGF1R_20145208_ChIP-Seq_DFB_Human1.19832319
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19341669
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19299787
70CDX2_22108803_ChIP-Seq_LS180_Human1.18731906
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18576466
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18447292
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.13393019
74MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.13288108
75SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12667158
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11624975
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11028269
78SOX2_19829295_ChIP-Seq_ESCs_Human1.10735509
79NANOG_19829295_ChIP-Seq_ESCs_Human1.10735509
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10023182
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.09174055
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08967388
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08087563
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05098185
85RUNX2_22187159_ChIP-Seq_PCA_Human1.05052976
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04363506
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02635880
88EED_16625203_ChIP-ChIP_MESCs_Mouse1.02138867
89AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00922818
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00752408
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.00215011
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99811582
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99163509
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.99001083
95OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98783794
96IRF8_22096565_ChIP-ChIP_GC-B_Human0.98521493
97TBL1_22424771_ChIP-Seq_293T_Human0.98370424
98KDM2B_26808549_Chip-Seq_REH_Human0.97965989
99P53_22387025_ChIP-Seq_ESCs_Mouse0.97210284
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94854393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane5.02440056
2MP0005171_absent_coat_pigmentation4.65046624
3MP0003136_yellow_coat_color4.48397050
4MP0000749_muscle_degeneration4.09799621
5MP0002837_dystrophic_cardiac_calcinosis4.05898724
6MP0000372_irregular_coat_pigmentation3.45556552
7MP0005187_abnormal_penis_morphology3.14408259
8MP0003806_abnormal_nucleotide_metabolis2.90830108
9MP0009780_abnormal_chondrocyte_physiolo2.81634266
10MP0003315_abnormal_perineum_morphology2.43087585
11MP0004084_abnormal_cardiac_muscle2.39248571
12MP0010030_abnormal_orbit_morphology2.30463565
13MP0001299_abnormal_eye_distance/2.01997381
14MP0003279_aneurysm2.00652103
15MP0002160_abnormal_reproductive_system1.99035308
16MP0008438_abnormal_cutaneous_collagen1.98231408
17MP0003646_muscle_fatigue1.97011691
18MP0005174_abnormal_tail_pigmentation1.96408389
19MP0009384_cardiac_valve_regurgitation1.90412855
20MP0006054_spinal_hemorrhage1.88643167
21MP0002102_abnormal_ear_morphology1.82545189
22MP0004215_abnormal_myocardial_fiber1.74430610
23MP0005408_hypopigmentation1.71766391
24MP0005360_urolithiasis1.68945883
25MP0005670_abnormal_white_adipose1.61379483
26MP0000538_abnormal_urinary_bladder1.56533581
27MP0004036_abnormal_muscle_relaxation1.55152242
28MP0005075_abnormal_melanosome_morpholog1.51074619
29MP0005595_abnormal_vascular_smooth1.49584612
30MP0005503_abnormal_tendon_morphology1.49168592
31MP0001485_abnormal_pinna_reflex1.47821765
32MP0002095_abnormal_skin_pigmentation1.43369468
33MP0002282_abnormal_trachea_morphology1.41892271
34MP0001984_abnormal_olfaction1.39782446
35MP0005253_abnormal_eye_physiology1.39773090
36MP0003195_calcinosis1.38330624
37MP0002090_abnormal_vision1.37451675
38MP0010368_abnormal_lymphatic_system1.37321134
39MP0002108_abnormal_muscle_morphology1.31602671
40MP0005620_abnormal_muscle_contractility1.30445025
41MP0008775_abnormal_heart_ventricle1.24931824
42MP0002876_abnormal_thyroid_physiology1.21525856
43MP0004272_abnormal_basement_membrane1.17812997
44MP0000015_abnormal_ear_pigmentation1.16165446
45MP0003045_fibrosis1.14709553
46MP0002269_muscular_atrophy1.11906304
47MP0009250_abnormal_appendicular_skeleto1.10694926
48MP0005551_abnormal_eye_electrophysiolog1.08443762
49MP0000534_abnormal_ureter_morphology1.07783987
50MP0002877_abnormal_melanocyte_morpholog1.07666541
51MP0004145_abnormal_muscle_electrophysio1.06258875
52MP0006072_abnormal_retinal_apoptosis1.05282004
53MP0000343_altered_response_to1.04893079
54MP0000759_abnormal_skeletal_muscle1.04830500
55MP0004233_abnormal_muscle_weight1.03624203
56MP0002938_white_spotting1.02095052
57MP0000767_abnormal_smooth_muscle1.00495596
58MP0000230_abnormal_systemic_arterial0.98837382
59MP0010386_abnormal_urinary_bladder0.98826197
60MP0005248_abnormal_Harderian_gland0.98615179
61MP0005083_abnormal_biliary_tract0.98352532
62MP0008004_abnormal_stomach_pH0.97975921
63MP0000371_diluted_coat_color0.96811467
64MP0004484_altered_response_of0.95360055
65MP0005623_abnormal_meninges_morphology0.94310772
66MP0000427_abnormal_hair_cycle0.90707016
67MP0002234_abnormal_pharynx_morphology0.88839427
68MP0000569_abnormal_digit_pigmentation0.86170795
69MP0001756_abnormal_urination0.85789179
70MP0005389_reproductive_system_phenotype0.85701175
71MP0005367_renal/urinary_system_phenotyp0.83549605
72MP0000516_abnormal_urinary_system0.83549605
73MP0005275_abnormal_skin_tensile0.81872427
74MP0003252_abnormal_bile_duct0.80609998
75MP0003011_delayed_dark_adaptation0.79788104
76MP0005330_cardiomyopathy0.79423805
77MP0002168_other_aberrant_phenotype0.79301045
78MP0006138_congestive_heart_failure0.79247603
79MP0001324_abnormal_eye_pigmentation0.79172825
80MP0003942_abnormal_urinary_system0.77304076
81MP0005084_abnormal_gallbladder_morpholo0.75653279
82MP0002751_abnormal_autonomic_nervous0.73831737
83MP0003828_pulmonary_edema0.72494141
84MP0003283_abnormal_digestive_organ0.72261851
85MP0000733_abnormal_muscle_development0.70645585
86MP0005508_abnormal_skeleton_morphology0.70241297
87MP0009840_abnormal_foam_cell0.68517244
88MP0003755_abnormal_palate_morphology0.67726186
89MP0004381_abnormal_hair_follicle0.67720246
90MP0005197_abnormal_uvea_morphology0.66965844
91MP0003879_abnormal_hair_cell0.65624776
92MP0005023_abnormal_wound_healing0.65028440
93MP0001958_emphysema0.64286166
94MP0001270_distended_abdomen0.64160911
95MP0000750_abnormal_muscle_regeneration0.61896536
96MP0004085_abnormal_heartbeat0.60950108
97MP0003705_abnormal_hypodermis_morpholog0.60365793
98MP0004087_abnormal_muscle_fiber0.60130828
99MP0005257_abnormal_intraocular_pressure0.57838214
100MP0005369_muscle_phenotype0.57589412

Predicted human phenotypes

RankGene SetZ-score
1Popliteal pterygium (HP:0009756)6.00310145
2Aplasia of the musculature (HP:0100854)5.04740226
3Type 2 muscle fiber atrophy (HP:0003554)4.98360041
4Congenital stationary night blindness (HP:0007642)4.95539524
5Amniotic constriction ring (HP:0009775)4.10553128
6Abnormality of placental membranes (HP:0011409)4.10553128
7Muscle fiber atrophy (HP:0100295)4.09696026
8Congenital sensorineural hearing impairment (HP:0008527)3.78418087
9Hyporeflexia of lower limbs (HP:0002600)3.69465244
10Abnormality of the neuromuscular junction (HP:0003398)3.65294904
11Fatigable weakness (HP:0003473)3.65294904
12Aplasia/Hypoplasia involving the musculature (HP:0001460)3.57342266
13Weak cry (HP:0001612)3.52345875
14Follicular hyperkeratosis (HP:0007502)3.47851157
15Decreased central vision (HP:0007663)3.47624510
16Fetal akinesia sequence (HP:0001989)3.27040936
17Clumsiness (HP:0002312)3.22631783
18Hypoplastic ischia (HP:0003175)3.21045498
19Scapular winging (HP:0003691)3.15425247
20Albinism (HP:0001022)3.03542480
21Malignant hyperthermia (HP:0002047)2.99125041
22Calf muscle hypertrophy (HP:0008981)2.96915867
23Aortic aneurysm (HP:0004942)2.91177238
24White forelock (HP:0002211)2.88570967
25Reduced antithrombin III activity (HP:0001976)2.87292187
26Akinesia (HP:0002304)2.84467019
27Ocular albinism (HP:0001107)2.83401575
28Abnormality of the shoulder girdle musculature (HP:0001435)2.76907269
29Abnormality of the ischium (HP:0003174)2.74133285
30Patchy hypopigmentation of hair (HP:0011365)2.70710070
31Absent/shortened dynein arms (HP:0200106)2.66419685
32Dynein arm defect of respiratory motile cilia (HP:0012255)2.66419685
33Abnormality of the calf musculature (HP:0001430)2.65837150
34Mesomelia (HP:0003027)2.62515246
35Easy fatigability (HP:0003388)2.62429398
36Gowers sign (HP:0003391)2.55518187
37Muscle hypertrophy of the lower extremities (HP:0008968)2.54249382
38Sensory axonal neuropathy (HP:0003390)2.52956867
39Iris hypopigmentation (HP:0007730)2.50172031
40Proximal amyotrophy (HP:0007126)2.46379176
41Pterygium (HP:0001059)2.44092348
42Small hand (HP:0200055)2.39848230
43Pancreatic cysts (HP:0001737)2.37766695
44Aplasia/Hypoplasia of the macula (HP:0008059)2.36521459
45Amblyopia (HP:0000646)2.30857416
46Inability to walk (HP:0002540)2.23454303
47Blue irides (HP:0000635)2.22845979
48Tubular atrophy (HP:0000092)2.20340596
49Generalized hypopigmentation (HP:0007513)2.20295543
50Cystic hygroma (HP:0000476)2.18955126
51Aplasia/Hypoplasia affecting the retina (HP:0008061)2.17630185
52Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.17266352
53Large for gestational age (HP:0001520)2.14609347
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.11786609
55Hypoplasia of the fovea (HP:0007750)2.11786609
56Attenuation of retinal blood vessels (HP:0007843)2.09058190
57Molar tooth sign on MRI (HP:0002419)2.07167063
58Abnormality of midbrain morphology (HP:0002418)2.07167063
59Delayed gross motor development (HP:0002194)2.05369154
60Abnormality of the renal cortex (HP:0011035)2.05235867
61Recurrent corneal erosions (HP:0000495)2.04747756
62Supernumerary spleens (HP:0009799)2.00947356
63Pancreatic fibrosis (HP:0100732)1.98205728
64Increased corneal curvature (HP:0100692)1.96798706
65Keratoconus (HP:0000563)1.96798706
66Abnormality of the renal medulla (HP:0100957)1.96429433
67Difficulty walking (HP:0002355)1.94979830
68Prolonged QT interval (HP:0001657)1.92484664
69Muscle fiber inclusion bodies (HP:0100299)1.90552158
70Chorioretinal atrophy (HP:0000533)1.89986605
71Gaze-evoked nystagmus (HP:0000640)1.87366951
72Horizontal nystagmus (HP:0000666)1.86570003
73Nephronophthisis (HP:0000090)1.86131429
74Bulbar palsy (HP:0001283)1.85949739
75Thin ribs (HP:0000883)1.84558361
76Nonprogressive disorder (HP:0003680)1.84072419
77Abnormal pancreas size (HP:0012094)1.84063470
78Lipoatrophy (HP:0100578)1.83182096
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82523084
80True hermaphroditism (HP:0010459)1.81424938
81Aortic dissection (HP:0002647)1.80844794
82Spondylolisthesis (HP:0003302)1.80660145
83Hypoplastic iliac wings (HP:0002866)1.79495833
84Hypoplastic heart (HP:0001961)1.77079385
85Exercise-induced muscle cramps (HP:0003710)1.76267240
86Abnormal respiratory epithelium morphology (HP:0012253)1.75079160
87Abnormal respiratory motile cilium morphology (HP:0005938)1.75079160
88Abnormality of the wing of the ilium (HP:0011867)1.74390086
89Abnormality of macular pigmentation (HP:0008002)1.74387948
90Hypoplastic labia majora (HP:0000059)1.74026003
91Hypopigmentation of the fundus (HP:0007894)1.72460733
92Abnormality of the fovea (HP:0000493)1.68596360
93Aplasia/Hypoplasia of the tongue (HP:0010295)1.67873007
94Nemaline bodies (HP:0003798)1.66871203
95Increased number of teeth (HP:0011069)1.64722462
96Respiratory insufficiency due to muscle weakness (HP:0002747)1.64465356
97Hypoplasia of the iris (HP:0007676)1.63469868
98Left ventricular hypertrophy (HP:0001712)1.63349166
99Furrowed tongue (HP:0000221)1.61255822
100Decreased muscle mass (HP:0003199)1.60458492

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.09024341
2LATS14.73036092
3INSRR4.29274447
4FRK4.26033488
5BMPR1B3.15839852
6STK38L2.85402108
7MUSK2.83653446
8AKT32.67403973
9MYLK2.52807578
10OBSCN2.31212651
11MARK32.25482413
12ACVR1B2.08262354
13MAPKAPK32.06003113
14LATS22.05946383
15MAP3K121.96239503
16CLK11.82831352
17EIF2AK31.77449466
18PAK31.67940813
19DDR21.66505556
20LIMK11.65034578
21STK31.39579530
22CCNB11.35933013
23NUAK11.34315371
24MELK1.30076893
25ILK1.26377248
26ADRBK21.21621974
27MAPK131.21171496
28PIK3CG1.19505067
29MAP4K21.17328465
30PNCK1.15509828
31EEF2K1.14722870
32TRPM71.13850576
33NEK91.10592573
34STK381.06822243
35MAP2K71.05526997
36PLK21.05157296
37TGFBR11.05098748
38ROCK10.97021362
39MAPKAPK50.89983830
40PAK20.88433318
41PRKD30.85899945
42PTK2B0.80585310
43GRK10.78309389
44CSNK1A1L0.71642400
45TAF10.70581757
46CDK80.64773419
47ADRBK10.64722760
48FER0.61541564
49BRSK20.60586148
50STK390.60378493
51MAPK120.58674122
52FGFR20.56922223
53STK240.56260792
54PRKAA20.53326312
55TLK10.53095125
56MAP2K10.51399675
57NEK20.50889095
58PRKCE0.50036573
59CSNK1G20.44912758
60PRKCQ0.44858669
61CDK30.44545565
62MAP3K50.42595475
63WEE10.42590512
64PLK30.41959432
65PRKCH0.41763217
66OXSR10.39661062
67TNIK0.39491428
68MAPK110.39115198
69DAPK20.36535443
70PHKG20.35642011
71PHKG10.35642011
72PRKCG0.34694946
73DMPK0.34363370
74ROCK20.33586156
75PDK20.33429918
76CDK90.32993191
77PRKG20.32621299
78WNK30.32308170
79NLK0.32040594
80TNK20.32021903
81GRK70.31792101
82PKN10.31755920
83MAP3K30.29934947
84SGK20.28092095
85KIT0.27295972
86CAMK2D0.26396759
87ZAK0.26026003
88ABL10.25747806
89MKNK20.25617263
90DAPK30.25324558
91MAPK150.24363795
92AKT20.22249490
93PRKG10.21360717
94SGK2230.20914017
95SGK4940.20914017
96CAMK1G0.20732311
97CASK0.19922740
98GRK50.19705799
99PRKACB0.19499872
100NEK60.18983814

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.22063269
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.83688057
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.54669049
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.51589805
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.42476065
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.19299544
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.96587429
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.91109201
9Dilated cardiomyopathy_Homo sapiens_hsa054141.85504675
10Mineral absorption_Homo sapiens_hsa049781.80862450
11Calcium signaling pathway_Homo sapiens_hsa040201.80361734
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80108299
13Phototransduction_Homo sapiens_hsa047441.78128887
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.73321529
15Circadian rhythm_Homo sapiens_hsa047101.69439850
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.65524881
17Olfactory transduction_Homo sapiens_hsa047401.60994222
18Hedgehog signaling pathway_Homo sapiens_hsa043401.60550142
19Selenocompound metabolism_Homo sapiens_hsa004501.59697756
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57938988
21TGF-beta signaling pathway_Homo sapiens_hsa043501.52582652
22Butanoate metabolism_Homo sapiens_hsa006501.48872574
23Dorso-ventral axis formation_Homo sapiens_hsa043201.44146751
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.41277281
25ECM-receptor interaction_Homo sapiens_hsa045121.39937243
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37672221
27Nitrogen metabolism_Homo sapiens_hsa009101.34476556
28Sphingolipid metabolism_Homo sapiens_hsa006001.30398419
29Basal transcription factors_Homo sapiens_hsa030221.29856507
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25261356
31Propanoate metabolism_Homo sapiens_hsa006401.21298329
32Tryptophan metabolism_Homo sapiens_hsa003801.20241489
33Chemical carcinogenesis_Homo sapiens_hsa052041.20007817
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18015867
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17800953
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15993216
37Melanoma_Homo sapiens_hsa052181.11877137
38Oxytocin signaling pathway_Homo sapiens_hsa049211.09212393
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08956290
40Hippo signaling pathway_Homo sapiens_hsa043901.07472821
41Basal cell carcinoma_Homo sapiens_hsa052171.06833183
42Fatty acid biosynthesis_Homo sapiens_hsa000611.06343964
43Salivary secretion_Homo sapiens_hsa049701.02154410
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01874341
45Histidine metabolism_Homo sapiens_hsa003401.01822216
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.00566581
47Protein export_Homo sapiens_hsa030600.98185280
48Taste transduction_Homo sapiens_hsa047420.97928968
49Sulfur metabolism_Homo sapiens_hsa009200.95074510
50Regulation of autophagy_Homo sapiens_hsa041400.94004559
51Renin secretion_Homo sapiens_hsa049240.93789371
52Morphine addiction_Homo sapiens_hsa050320.86438478
53Linoleic acid metabolism_Homo sapiens_hsa005910.84698783
54Circadian entrainment_Homo sapiens_hsa047130.83938015
55Tight junction_Homo sapiens_hsa045300.83670172
56Focal adhesion_Homo sapiens_hsa045100.82951101
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82638401
58Wnt signaling pathway_Homo sapiens_hsa043100.81390930
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81309360
60beta-Alanine metabolism_Homo sapiens_hsa004100.81048621
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79461865
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79429205
63GABAergic synapse_Homo sapiens_hsa047270.79154154
64RNA polymerase_Homo sapiens_hsa030200.78168947
65Melanogenesis_Homo sapiens_hsa049160.77369183
66ABC transporters_Homo sapiens_hsa020100.71450748
67Retinol metabolism_Homo sapiens_hsa008300.71046788
68Collecting duct acid secretion_Homo sapiens_hsa049660.70488177
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70024320
70cAMP signaling pathway_Homo sapiens_hsa040240.67453758
71Gastric acid secretion_Homo sapiens_hsa049710.66671413
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65392610
73Insulin secretion_Homo sapiens_hsa049110.62903397
74Glycerolipid metabolism_Homo sapiens_hsa005610.62568826
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62488775
76Adherens junction_Homo sapiens_hsa045200.61519788
77Purine metabolism_Homo sapiens_hsa002300.60967214
78One carbon pool by folate_Homo sapiens_hsa006700.59628829
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58469359
80Pyruvate metabolism_Homo sapiens_hsa006200.57559186
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57219227
82Complement and coagulation cascades_Homo sapiens_hsa046100.57068931
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55859988
84Cardiac muscle contraction_Homo sapiens_hsa042600.54767102
85Sulfur relay system_Homo sapiens_hsa041220.54431247
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53695965
87Arginine and proline metabolism_Homo sapiens_hsa003300.53627543
88Fatty acid degradation_Homo sapiens_hsa000710.52696565
89Proteoglycans in cancer_Homo sapiens_hsa052050.49582398
90PPAR signaling pathway_Homo sapiens_hsa033200.49318836
91Nicotine addiction_Homo sapiens_hsa050330.48797359
92Glucagon signaling pathway_Homo sapiens_hsa049220.48782161
93Homologous recombination_Homo sapiens_hsa034400.48371836
94N-Glycan biosynthesis_Homo sapiens_hsa005100.48275985
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47863286
96Caffeine metabolism_Homo sapiens_hsa002320.47769372
97Glutamatergic synapse_Homo sapiens_hsa047240.46643522
98Metabolic pathways_Homo sapiens_hsa011000.46368339
99Axon guidance_Homo sapiens_hsa043600.44653763
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43988539

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