LMTK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.89718687
2locomotory exploration behavior (GO:0035641)5.72332274
3synaptic vesicle maturation (GO:0016188)5.70616770
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.53561824
5vocalization behavior (GO:0071625)5.38506908
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.04268969
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.90759598
8glutamate secretion (GO:0014047)4.77793589
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.67945481
10synaptic vesicle exocytosis (GO:0016079)4.67136967
11regulation of glutamate receptor signaling pathway (GO:1900449)4.45135275
12regulation of synaptic vesicle exocytosis (GO:2000300)4.36636946
13layer formation in cerebral cortex (GO:0021819)4.35920395
14regulation of synapse structural plasticity (GO:0051823)4.20916203
15regulation of long-term neuronal synaptic plasticity (GO:0048169)4.16443554
16dendritic spine morphogenesis (GO:0060997)4.12180378
17neurotransmitter secretion (GO:0007269)4.06091906
18regulation of neuronal synaptic plasticity (GO:0048168)4.02781479
19exploration behavior (GO:0035640)4.00509948
20sodium ion export (GO:0071436)3.95905874
21protein localization to synapse (GO:0035418)3.94625450
22neuronal action potential propagation (GO:0019227)3.89630779
23regulation of synaptic vesicle transport (GO:1902803)3.83620213
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.81713837
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.79267859
26cellular potassium ion homeostasis (GO:0030007)3.77461028
27positive regulation of synapse maturation (GO:0090129)3.76652611
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.70587798
29proline transport (GO:0015824)3.68892193
30negative regulation of dendrite morphogenesis (GO:0050774)3.68171058
31synaptic transmission, glutamatergic (GO:0035249)3.65525163
32neurotransmitter-gated ion channel clustering (GO:0072578)3.63691666
33activation of protein kinase A activity (GO:0034199)3.63029062
34regulation of dendritic spine morphogenesis (GO:0061001)3.53264204
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.52814136
36neuromuscular process controlling balance (GO:0050885)3.51929150
37neuron-neuron synaptic transmission (GO:0007270)3.48547116
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48115074
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.46450837
40positive regulation of membrane potential (GO:0045838)3.45893611
41long-term memory (GO:0007616)3.44433562
42cytoskeletal anchoring at plasma membrane (GO:0007016)3.41670026
43cell communication by electrical coupling (GO:0010644)3.39779865
44G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.34133488
45glutamate receptor signaling pathway (GO:0007215)3.32323836
46regulation of postsynaptic membrane potential (GO:0060078)3.30280820
47prepulse inhibition (GO:0060134)3.28520710
48regulation of synaptic plasticity (GO:0048167)3.28419682
49regulation of ARF protein signal transduction (GO:0032012)3.27656760
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.26700454
51neuron cell-cell adhesion (GO:0007158)3.17518386
52cerebellar Purkinje cell differentiation (GO:0021702)3.16008848
53auditory behavior (GO:0031223)3.15356874
54dendritic spine organization (GO:0097061)3.14032043
55embryonic retina morphogenesis in camera-type eye (GO:0060059)3.13912440
56response to histamine (GO:0034776)3.13123063
57L-amino acid import (GO:0043092)3.12880337
58neurotransmitter transport (GO:0006836)3.08784931
59positive regulation of neurotransmitter transport (GO:0051590)3.06206290
60amino acid import (GO:0043090)3.06058728
61regulation of clathrin-mediated endocytosis (GO:2000369)3.04613622
62vesicle transport along microtubule (GO:0047496)3.02615087
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02146309
64long-term synaptic potentiation (GO:0060291)3.01829291
65establishment of nucleus localization (GO:0040023)3.00721410
66gamma-aminobutyric acid transport (GO:0015812)3.00658567
67cell communication involved in cardiac conduction (GO:0086065)3.00613628
68positive regulation of neurotransmitter secretion (GO:0001956)2.97959931
69bundle of His cell to Purkinje myocyte communication (GO:0086069)2.97939989
70desmosome organization (GO:0002934)2.97781650
71membrane hyperpolarization (GO:0060081)2.97071935
72chemosensory behavior (GO:0007635)2.92480935
73innervation (GO:0060384)2.91839654
74neuronal ion channel clustering (GO:0045161)2.91601390
75membrane depolarization during action potential (GO:0086010)2.89691505
76synaptic vesicle endocytosis (GO:0048488)2.89674299
77regulation of neurotransmitter secretion (GO:0046928)2.89361276
78glycine transport (GO:0015816)2.88296902
79regulation of Rac protein signal transduction (GO:0035020)2.86910194
80regulation of synaptic transmission, glutamatergic (GO:0051966)2.84354644
81potassium ion import (GO:0010107)2.83329654
82regulation of cholesterol homeostasis (GO:2000188)2.82657412
83long term synaptic depression (GO:0060292)2.82106961
84regulation of neurotransmitter levels (GO:0001505)2.81450851
85regulation of dendritic spine development (GO:0060998)2.81389038
86negative regulation of organelle assembly (GO:1902116)2.79897422
87axonal fasciculation (GO:0007413)2.79016719
88neuron recognition (GO:0008038)2.78843522
89behavioral defense response (GO:0002209)2.78567034
90behavioral fear response (GO:0001662)2.78567034
91dendrite morphogenesis (GO:0048813)2.78173571
92membrane depolarization (GO:0051899)2.77690214
93regulation of voltage-gated calcium channel activity (GO:1901385)2.75611814
94neuromuscular process (GO:0050905)2.71860511
95response to auditory stimulus (GO:0010996)2.70927884
96cell migration in hindbrain (GO:0021535)2.69646272
97regulation of synapse maturation (GO:0090128)2.69525162
98cerebellar granule cell differentiation (GO:0021707)2.67680680
99regulation of neurotransmitter transport (GO:0051588)2.65948702
100positive regulation of dendritic spine morphogenesis (GO:0061003)2.65906276
101transmission of nerve impulse (GO:0019226)2.65771731
102regulation of NFAT protein import into nucleus (GO:0051532)2.65051415
103intraspecies interaction between organisms (GO:0051703)2.64723919
104social behavior (GO:0035176)2.64723919
105cellular sodium ion homeostasis (GO:0006883)2.63672213
106activation of Rac GTPase activity (GO:0032863)2.63112264
107positive regulation of synaptic transmission (GO:0050806)2.60732612
108striatum development (GO:0021756)2.59668850
109fear response (GO:0042596)2.58574925
110regulation of ion transmembrane transporter activity (GO:0032412)2.58171430
111* peptidyl-threonine phosphorylation (GO:0018107)2.57622731
112potassium ion homeostasis (GO:0055075)2.56135731
113cardiac conduction (GO:0061337)2.53320193
114* peptidyl-threonine modification (GO:0018210)2.51197770
115histone H3-K36 demethylation (GO:0070544)2.50690126
116adherens junction assembly (GO:0034333)2.49666458
117ventricular cardiac muscle cell action potential (GO:0086005)2.49433123
118regulation of heart rate by cardiac conduction (GO:0086091)2.44490110
119cell-substrate adherens junction assembly (GO:0007045)2.41708946
120focal adhesion assembly (GO:0048041)2.41708946
121myotube differentiation (GO:0014902)2.41605671
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.41600851
123muscle hypertrophy in response to stress (GO:0003299)2.37579865
124cardiac muscle adaptation (GO:0014887)2.37579865
125cardiac muscle hypertrophy in response to stress (GO:0014898)2.37579865
126insulin-like growth factor receptor signaling pathway (GO:0048009)2.35305853
127histone H3-K9 demethylation (GO:0033169)2.32644642
128embryonic camera-type eye morphogenesis (GO:0048596)2.30453780
129nuclear pore complex assembly (GO:0051292)2.29688949
130apical protein localization (GO:0045176)2.28392992
131cellular response to monoamine stimulus (GO:0071868)2.23008865
132cellular response to catecholamine stimulus (GO:0071870)2.23008865
133positive regulation of Rap GTPase activity (GO:0032854)2.22743483
134phosphate ion transmembrane transport (GO:0035435)2.22321337
135regulation of dendrite morphogenesis (GO:0048814)2.21199825
136regulation of Rap GTPase activity (GO:0032317)2.20751624
137positive regulation of glucose transport (GO:0010828)2.20717960
138cardiac muscle hypertrophy (GO:0003300)2.19637250
139positive regulation of dendritic spine development (GO:0060999)2.19343137
140positive regulation of macroautophagy (GO:0016239)2.18179724
141mating behavior (GO:0007617)2.17799965
142cardiac muscle cell action potential involved in contraction (GO:0086002)2.17732055
143cytoplasmic mRNA processing body assembly (GO:0033962)2.16165601
144cardiac muscle cell action potential (GO:0086001)2.14632507
145positive regulation of glucose import (GO:0046326)2.14624176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.68173192
2* RARB_27405468_Chip-Seq_BRAIN_Mouse2.95310443
3DROSHA_22980978_ChIP-Seq_HELA_Human2.92409937
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.70383045
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46364182
6GBX2_23144817_ChIP-Seq_PC3_Human2.46270478
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42863926
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38006161
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.37597316
10REST_21632747_ChIP-Seq_MESCs_Mouse2.35194559
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27810289
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18858465
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18858465
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.11023800
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.06396779
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06316874
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04888540
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04402682
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97924301
20REST_18959480_ChIP-ChIP_MESCs_Mouse1.93339612
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92661768
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.87388071
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79201592
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78020864
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.77865270
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75101389
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.72866166
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.71768620
29KDM2B_26808549_Chip-Seq_K562_Human1.71723063
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70107762
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.68975951
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.68311211
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.68185367
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66471411
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63585974
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54830910
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51698127
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50119149
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49158579
40AR_21572438_ChIP-Seq_LNCaP_Human1.47379120
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47127692
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.46924197
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.46859217
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46452402
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45927274
46AHR_22903824_ChIP-Seq_MCF-7_Human1.44550712
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43480455
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.43431249
49* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43376292
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42307389
51TCF7_22412390_ChIP-Seq_EML_Mouse1.38743344
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.38454365
53* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38352198
54AR_19668381_ChIP-Seq_PC3_Human1.38167710
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37605727
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36197220
57SMAD4_21799915_ChIP-Seq_A2780_Human1.35964185
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35711502
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33423483
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.32868531
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30374504
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30106039
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30068778
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29764473
65CDX2_20551321_ChIP-Seq_CACO-2_Human1.29753316
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28708141
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27497522
68ISL1_27105846_Chip-Seq_CPCs_Mouse1.26169709
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25185287
70TP53_16413492_ChIP-PET_HCT116_Human1.24642868
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.23798486
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.23037997
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22855135
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.22705630
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20379298
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.18133790
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17700367
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16767302
79CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16668063
80* STAT3_23295773_ChIP-Seq_U87_Human1.15681693
81SMAD3_21741376_ChIP-Seq_HESCs_Human1.15587146
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15062847
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12620473
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11984179
85RACK7_27058665_Chip-Seq_MCF-7_Human1.11906187
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11673946
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.11332369
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11144411
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10671367
90RXR_22108803_ChIP-Seq_LS180_Human1.10416580
91KDM2B_26808549_Chip-Seq_DND41_Human1.09931152
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07100772
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06720193
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06193621
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05727133
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04609843
97CLOCK_20551151_ChIP-Seq_293T_Human1.03753574
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03716711
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.03596180
100TBX20_22080862_ChIP-Seq_HEART_Mouse1.03596180
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03018335
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02993737
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02842529
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01032381
105SMAD4_21741376_ChIP-Seq_HESCs_Human1.00856975
106PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99502629
107ESR2_21235772_ChIP-Seq_MCF-7_Human0.99464994
108KDM2B_26808549_Chip-Seq_JURKAT_Human0.99213948
109* TCF4_23295773_ChIP-Seq_U87_Human0.98808097
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98245723
111ZNF274_21170338_ChIP-Seq_K562_Hela0.98181764
112SMAD3_21741376_ChIP-Seq_EPCs_Human0.97449451
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97180884
114AR_25329375_ChIP-Seq_VCAP_Human0.96966603
115TCF4_18268006_ChIP-ChIP_LS174T_Human0.96633077
116LXR_22158963_ChIP-Seq_LIVER_Mouse0.96574133
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95667072
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95100627
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92285080
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92232136
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.92111000
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91966220
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91928994
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91747272
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.91368095
126ZNF263_19887448_ChIP-Seq_K562_Human0.91259899
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89481917
128* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88157193
129CTCF_27219007_Chip-Seq_Bcells_Human0.87833555
130CREB1_26743006_Chip-Seq_LNCaP_Human0.87765939
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.87331514
132GATA1_26923725_Chip-Seq_HPCs_Mouse0.86859266
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86607801
134TET1_21490601_ChIP-Seq_MESCs_Mouse0.86230515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.13746316
2MP0002822_catalepsy4.07756055
3MP0003635_abnormal_synaptic_transmissio4.06116766
4MP0004270_analgesia3.69245223
5MP0003880_abnormal_central_pattern3.60233514
6MP0002063_abnormal_learning/memory/cond3.30586663
7MP0009745_abnormal_behavioral_response3.15015181
8MP0009780_abnormal_chondrocyte_physiolo2.87383448
9MP0009046_muscle_twitch2.84744345
10MP0010234_abnormal_vibrissa_follicle2.82511223
11MP0002064_seizures2.73473913
12MP0005409_darkened_coat_color2.64594613
13MP0002572_abnormal_emotion/affect_behav2.51450273
14MP0003123_paternal_imprinting2.44567501
15MP0002734_abnormal_mechanical_nocicepti2.23433330
16MP0001486_abnormal_startle_reflex2.21601146
17MP0002909_abnormal_adrenal_gland2.15714120
18MP0003283_abnormal_digestive_organ2.15196980
19MP0005423_abnormal_somatic_nervous2.03283201
20MP0002272_abnormal_nervous_system2.02431128
21MP0002009_preneoplasia1.98468956
22MP0001968_abnormal_touch/_nociception1.97087372
23MP0010352_gastrointestinal_tract_polyps1.97081773
24MP0004858_abnormal_nervous_system1.96627532
25MP0008569_lethality_at_weaning1.92236437
26MP0003787_abnormal_imprinting1.88791687
27MP0004885_abnormal_endolymph1.87533494
28MP0001501_abnormal_sleep_pattern1.84756432
29MP0003122_maternal_imprinting1.83522600
30MP0008961_abnormal_basal_metabolism1.77667672
31MP0004811_abnormal_neuron_physiology1.77435488
32MP0000566_synostosis1.76054397
33MP0000569_abnormal_digit_pigmentation1.68878701
34MP0003879_abnormal_hair_cell1.65744032
35MP0000537_abnormal_urethra_morphology1.64706194
36MP0001440_abnormal_grooming_behavior1.61709293
37MP0000579_abnormal_nail_morphology1.58394152
38MP0002733_abnormal_thermal_nociception1.56639316
39MP0002557_abnormal_social/conspecific_i1.55717954
40MP0004924_abnormal_behavior1.55266934
41MP0005386_behavior/neurological_phenoty1.55266934
42MP0003329_amyloid_beta_deposits1.53801237
43MP0010678_abnormal_skin_adnexa1.51569517
44MP0002796_impaired_skin_barrier1.50366505
45MP0000778_abnormal_nervous_system1.48557297
46MP0001970_abnormal_pain_threshold1.45758124
47MP0002067_abnormal_sensory_capabilities1.42811189
48MP0008057_abnormal_DNA_replication1.41699868
49MP0000955_abnormal_spinal_cord1.41185174
50MP0002184_abnormal_innervation1.37054582
51MP0005451_abnormal_body_composition1.31915594
52MP0003633_abnormal_nervous_system1.30935332
53MP0002735_abnormal_chemical_nociception1.26958399
54MP0001348_abnormal_lacrimal_gland1.26265962
55MP0000751_myopathy1.22394195
56MP0003690_abnormal_glial_cell1.21847395
57MP0002066_abnormal_motor_capabilities/c1.21487530
58MP0003868_abnormal_feces_composition1.18617680
59MP0002837_dystrophic_cardiac_calcinosis1.17804218
60MP0003566_abnormal_cell_adhesion1.16448879
61MP0004233_abnormal_muscle_weight1.15999502
62MP0009672_abnormal_birth_weight1.14374201
63MP0001177_atelectasis1.14060251
64MP0002882_abnormal_neuron_morphology1.12438672
65MP0004264_abnormal_extraembryonic_tissu1.10985587
66MP0002736_abnormal_nociception_after1.10751265
67MP0003045_fibrosis1.09695206
68MP0002152_abnormal_brain_morphology1.09451590
69MP0008872_abnormal_physiological_respon1.06549459
70MP0010630_abnormal_cardiac_muscle1.06218001
71MP0003631_nervous_system_phenotype1.05054404
72MP0006138_congestive_heart_failure1.04441267
73MP0008874_decreased_physiological_sensi1.04301054
74MP0004085_abnormal_heartbeat1.03581135
75MP0005646_abnormal_pituitary_gland1.02949629
76MP0005076_abnormal_cell_differentiation1.01023639
77MP0004215_abnormal_myocardial_fiber1.00325464
78MP0003705_abnormal_hypodermis_morpholog0.98556566
79MP0001346_abnormal_lacrimal_gland0.98312339
80MP0004043_abnormal_pH_regulation0.95829572
81MP0005167_abnormal_blood-brain_barrier0.95143650
82MP0005623_abnormal_meninges_morphology0.92884116
83MP0003453_abnormal_keratinocyte_physiol0.92508896
84MP0003634_abnormal_glial_cell0.91327889
85MP0000920_abnormal_myelination0.90932703
86MP0004130_abnormal_muscle_cell0.89778589
87MP0004484_altered_response_of0.89635675
88MP0004185_abnormal_adipocyte_glucose0.87711591
89MP0005666_abnormal_adipose_tissue0.86415530
90MP0001666_abnormal_nutrient_absorption0.86020734
91MP0002069_abnormal_eating/drinking_beha0.85776566
92MP0005187_abnormal_penis_morphology0.85707599
93MP0000013_abnormal_adipose_tissue0.85492086
94MP0004087_abnormal_muscle_fiber0.84949757
95MP0003091_abnormal_cell_migration0.83261418
96MP0002234_abnormal_pharynx_morphology0.82961556
97MP0009703_decreased_birth_body0.82016629
98MP0002098_abnormal_vibrissa_morphology0.81496493
99MP0004145_abnormal_muscle_electrophysio0.79969973
100MP0003890_abnormal_embryonic-extraembry0.79154464
101MP0003183_abnormal_peptide_metabolism0.78295245
102MP0001984_abnormal_olfaction0.78163475
103MP0000383_abnormal_hair_follicle0.76827927
104MP0003075_altered_response_to0.76133837
105MP0003137_abnormal_impulse_conducting0.75021240
106MP0003115_abnormal_respiratory_system0.74914562
107MP0005535_abnormal_body_temperature0.74786437
108MP0001502_abnormal_circadian_rhythm0.74046430
109MP0003119_abnormal_digestive_system0.73857876
110MP0003632_abnormal_nervous_system0.72625027
111MP0000462_abnormal_digestive_system0.70855601
112MP0000747_muscle_weakness0.70822690
113MP0002653_abnormal_ependyma_morphology0.69246058
114MP0000678_abnormal_parathyroid_gland0.68359160
115MP0003861_abnormal_nervous_system0.68312563
116MP0004036_abnormal_muscle_relaxation0.67513332
117MP0002082_postnatal_lethality0.67065577
118MP0010770_preweaning_lethality0.67065577
119MP0005645_abnormal_hypothalamus_physiol0.64956823
120MP0005248_abnormal_Harderian_gland0.62901560
121MP0004084_abnormal_cardiac_muscle0.61724733
122MP0003300_gastrointestinal_ulcer0.61494221
123MP0001765_abnormal_ion_homeostasis0.61464531
124MP0005620_abnormal_muscle_contractility0.60598355
125MP0002269_muscular_atrophy0.60321773
126MP0002877_abnormal_melanocyte_morpholog0.59538128
127MP0001943_abnormal_respiration0.59475175
128MP0001849_ear_inflammation0.58731274
129MP0002229_neurodegeneration0.57033516
130MP0003646_muscle_fatigue0.56736899
131MP0010769_abnormal_survival0.56590232
132MP0000604_amyloidosis0.55770758
133MP0001299_abnormal_eye_distance/0.55517666
134MP0004742_abnormal_vestibular_system0.55470955
135MP0005499_abnormal_olfactory_system0.53895960
136MP0005394_taste/olfaction_phenotype0.53895960
137MP0001664_abnormal_digestion0.53185350
138MP0002089_abnormal_postnatal_growth/wei0.53172864
139MP0000631_abnormal_neuroendocrine_gland0.53045810
140MP0000003_abnormal_adipose_tissue0.52991824

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.84512929
2Myokymia (HP:0002411)5.31478042
3Focal seizures (HP:0007359)4.88634726
4Visual hallucinations (HP:0002367)4.23278615
5Epileptic encephalopathy (HP:0200134)3.64720112
6Abnormality of the lower motor neuron (HP:0002366)3.38775396
7Febrile seizures (HP:0002373)3.35361882
8Dysmetric saccades (HP:0000641)3.35215882
9Impaired vibration sensation in the lower limbs (HP:0002166)3.33604410
10Right ventricular cardiomyopathy (HP:0011663)3.27561918
11Poor eye contact (HP:0000817)3.21848294
12Abnormal social behavior (HP:0012433)3.21462007
13Impaired social interactions (HP:0000735)3.21462007
14Action tremor (HP:0002345)3.16894362
15Papilledema (HP:0001085)3.06951770
16Urinary bladder sphincter dysfunction (HP:0002839)2.96376560
17Progressive cerebellar ataxia (HP:0002073)2.95742642
18Dysdiadochokinesis (HP:0002075)2.95223731
19Absence seizures (HP:0002121)2.94416770
20Broad-based gait (HP:0002136)2.90371607
21Atonic seizures (HP:0010819)2.89226100
22Generalized tonic-clonic seizures (HP:0002069)2.88517864
23Ankyloglossia (HP:0010296)2.87966826
24Gaze-evoked nystagmus (HP:0000640)2.87516971
25Impaired smooth pursuit (HP:0007772)2.83339975
26Urinary urgency (HP:0000012)2.78535855
27Depression (HP:0000716)2.68422667
28Resting tremor (HP:0002322)2.66525767
29Insomnia (HP:0100785)2.66461416
30Postural instability (HP:0002172)2.65939389
31Ankle clonus (HP:0011448)2.64676247
32Pointed chin (HP:0000307)2.64546535
33Abnormality of the fingertips (HP:0001211)2.61911294
34Ventricular fibrillation (HP:0001663)2.60518728
35Truncal ataxia (HP:0002078)2.59288240
36Dialeptic seizures (HP:0011146)2.57212701
37Lower limb amyotrophy (HP:0007210)2.49956135
38Bundle branch block (HP:0011710)2.49099314
39Abnormality of ocular smooth pursuit (HP:0000617)2.47217471
40Annular pancreas (HP:0001734)2.46068267
41Hyperacusis (HP:0010780)2.45803539
42Elfin facies (HP:0004428)2.43392840
43Hemiplegia (HP:0002301)2.37329183
44Genetic anticipation (HP:0003743)2.37241526
45Dysmetria (HP:0001310)2.35860446
46Supranuclear gaze palsy (HP:0000605)2.34009950
47Subacute progressive viral hepatitis (HP:0006572)2.29771205
48Impaired vibratory sensation (HP:0002495)2.29594815
49Abnormality of the astrocytes (HP:0100707)2.28883167
50Astrocytoma (HP:0009592)2.28883167
51Germ cell neoplasia (HP:0100728)2.25754091
52Difficulty running (HP:0009046)2.25338104
53Amblyopia (HP:0000646)2.24454565
54Hyporeflexia of lower limbs (HP:0002600)2.24197936
55Stereotypic behavior (HP:0000733)2.23706764
56Hyperventilation (HP:0002883)2.22793306
57Flat acetabular roof (HP:0003180)2.20647835
58Neurofibrillary tangles (HP:0002185)2.18417782
59Excessive salivation (HP:0003781)2.17248199
60Drooling (HP:0002307)2.17248199
61Abnormality of oral frenula (HP:0000190)2.17008229
62Intention tremor (HP:0002080)2.12748559
63Anal stenosis (HP:0002025)2.11973379
64Papillary thyroid carcinoma (HP:0002895)2.10413509
65Intellectual disability, profound (HP:0002187)2.09425784
66Abnormal eating behavior (HP:0100738)2.09082406
67Scanning speech (HP:0002168)2.07866239
68Thickened helices (HP:0000391)2.06310867
69Urethral obstruction (HP:0000796)2.04811299
70Torticollis (HP:0000473)2.03364054
71Hemiparesis (HP:0001269)2.03278087
72Insidious onset (HP:0003587)2.01970571
73Termporal pattern (HP:0011008)2.01970571
74Bradykinesia (HP:0002067)2.01876234
75Macroorchidism (HP:0000053)2.01378216
76Broad face (HP:0000283)2.00916188
77Obsessive-compulsive behavior (HP:0000722)2.00776391
78Septate vagina (HP:0001153)2.00599734
79Epileptiform EEG discharges (HP:0011182)1.97281316
80Abnormality of the salivary glands (HP:0010286)1.95917982
81Abnormality of the distal phalanx of the thumb (HP:0009617)1.95794978
82Asymmetry of the thorax (HP:0001555)1.95628587
83Spastic gait (HP:0002064)1.94731911
84Lower limb muscle weakness (HP:0007340)1.94494954
85Anxiety (HP:0000739)1.92534140
86Amyotrophic lateral sclerosis (HP:0007354)1.92466049
87Decreased motor nerve conduction velocity (HP:0003431)1.91219851
88Hyperkalemia (HP:0002153)1.89689134
89EEG with generalized epileptiform discharges (HP:0011198)1.89585776
90Advanced eruption of teeth (HP:0006288)1.89189204
91Upper limb amyotrophy (HP:0009129)1.87675930
92Distal upper limb amyotrophy (HP:0007149)1.87675930
93Renovascular hypertension (HP:0100817)1.87456547
94Status epilepticus (HP:0002133)1.85637302
95Curly hair (HP:0002212)1.84991014
96Hepatoblastoma (HP:0002884)1.84926015
97Hypsarrhythmia (HP:0002521)1.84049248
98Aplasia involving bones of the upper limbs (HP:0009823)1.84046029
99Aplasia of the phalanges of the hand (HP:0009802)1.84046029
100Aplasia involving bones of the extremities (HP:0009825)1.84046029
101Absent speech (HP:0001344)1.83509653
102Vertebral arch anomaly (HP:0008438)1.83422316
103Diplopia (HP:0000651)1.81389557
104Abnormality of binocular vision (HP:0011514)1.81389557
105Aqueductal stenosis (HP:0002410)1.80941505
106Ependymoma (HP:0002888)1.77196273
107Subaortic stenosis (HP:0001682)1.76723778
108Abnormality of the left ventricular outflow tract (HP:0011103)1.76723778
109Heterotopia (HP:0002282)1.75816485
110Abnormality of the nasal septum (HP:0000419)1.75454604
111Cerebral inclusion bodies (HP:0100314)1.75358744
112Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73189541
113Overriding aorta (HP:0002623)1.72399561
114Prolonged QT interval (HP:0001657)1.71444379
115Abnormal EKG (HP:0003115)1.71268172
116Megalencephaly (HP:0001355)1.70775716
117Abnormality of the labia minora (HP:0012880)1.70289367
118Focal dystonia (HP:0004373)1.70135314
119Sudden death (HP:0001699)1.69303734
120Syncope (HP:0001279)1.68335486
121Incomplete penetrance (HP:0003829)1.68170456
122Abnormality of the gastric mucosa (HP:0004295)1.68087417
123Enlarged penis (HP:0000040)1.67501030
124Onion bulb formation (HP:0003383)1.67457245
125Blue irides (HP:0000635)1.66392747
126Mutism (HP:0002300)1.65685540
127Hand muscle atrophy (HP:0009130)1.65669448
128Distal lower limb amyotrophy (HP:0008944)1.64353162
129Clonus (HP:0002169)1.63848277
130Lower limb asymmetry (HP:0100559)1.61892560
131Precocious puberty (HP:0000826)1.61876722
132Obstructive sleep apnea (HP:0002870)1.61353637
133Bronchomalacia (HP:0002780)1.60925195
134Laryngomalacia (HP:0001601)1.60322715
135Renal duplication (HP:0000075)1.60122672
136Cerebral aneurysm (HP:0004944)1.59603704
137Cubitus valgus (HP:0002967)1.57651401
138Increased circulating renin level (HP:0000848)1.56616182
139Neonatal hypoglycemia (HP:0001998)1.56590810
140Relative macrocephaly (HP:0004482)1.56253994
141Arterial tortuosity (HP:0005116)1.56025006
142Pheochromocytoma (HP:0002666)1.55489942
143Deep venous thrombosis (HP:0002625)1.55449256
144Slow saccadic eye movements (HP:0000514)1.55364222
145Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.53523965
146Bifid scrotum (HP:0000048)1.51618688
147Bowel incontinence (HP:0002607)1.51053929
148Akinesia (HP:0002304)1.50038986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.29516337
2MAP3K94.19145851
3NTRK33.60632061
4EEF2K2.72563694
5MAP3K42.72502774
6DAPK22.65891715
7KSR22.45041829
8MARK12.38279483
9PRKD32.34975420
10KSR12.29464383
11CAMKK12.27325641
12MINK12.19377949
13NTRK12.14254095
14NTRK22.08724618
15PAK62.07394880
16MST1R1.92974075
17MAP3K21.88711898
18RIPK11.88532123
19BRD41.62119014
20STK381.61603392
21TAOK11.58205305
22DAPK11.54596503
23FGFR41.51553346
24RIPK41.49224066
25FGFR31.48869478
26LATS11.48079410
27TYRO31.43043706
28SIK11.35734333
29SMG11.34777345
30SIK21.34751064
31CAMK1G1.31689911
32MAP2K41.29703825
33MAP2K71.29249496
34ALK1.22983410
35NEK61.22867732
36LMTK21.22585416
37* CDK51.21212955
38STK111.19728573
39CAMKK21.17848655
40SGK31.16743336
41CDK121.13276161
42NEK11.10976987
43IRAK21.06442468
44PNCK1.06091008
45LATS21.01637856
46SGK21.00976316
47CAMK1D0.98708563
48MTOR0.98640701
49MET0.97916606
50PRKCH0.95750449
51RET0.94214443
52TRIB30.93602810
53MAP3K70.93035421
54STK390.86416956
55MAP3K100.86122804
56SGK4940.83476469
57SGK2230.83476469
58PRKCG0.81673396
59CAMK10.81595461
60SCYL20.81575112
61BMX0.80897947
62PLK20.80595190
63SIK30.80475135
64SGK10.80353543
65AKT30.79866548
66PKN20.78616300
67PRPF4B0.77526875
68DMPK0.77096739
69ICK0.76285587
70EPHA20.75301930
71PDGFRA0.73881946
72MARK20.73522074
73TTN0.72983091
74PDK10.72248113
75YES10.70192337
76PAK30.69856489
77STK240.69076972
78RAF10.68616113
79MAP3K130.68384644
80PDK30.65716094
81PDK40.65716094
82PDPK10.65523177
83MAP3K60.65412845
84CDC42BPA0.65008358
85CAMK40.64571820
86FRK0.63307936
87CDK180.63217108
88GRK50.63045143
89UHMK10.61935718
90PRKAA20.60811742
91PHKG10.59860481
92PHKG20.59860481
93WNK10.59216184
94CDK150.58424238
95RPS6KB10.57996846
96PRKCZ0.56858044
97RPS6KA30.56801899
98FES0.56382042
99ERBB20.56244863
100PTK2B0.56143580
101MAPK120.56012278
102WNK30.55331580
103MAP3K10.54898255
104PDGFRB0.52689129
105CAMK2A0.52373247
106FGFR20.51914752
107CAMK2B0.49802531
108MAP3K30.47808712
109CDK11A0.47015632
110DYRK1A0.46793784
111PTK60.45692645
112MAP2K10.45591982
113CDK140.45503346
114FER0.45281528
115MAPK100.45061102
116EPHB20.45054371
117PIK3CA0.41708911
118MAPK130.40976579
119MELK0.40820509
120FYN0.39544615
121PRKAA10.39262010
122CASK0.38069760
123STK38L0.37960175
124GSK3B0.37938328
125CSNK1D0.37153875
126MAP3K120.37008170
127PINK10.34775169
128PTK20.34520008
129CDK190.34163198
130GRK60.33139567
131MAPK80.32321411

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.69346389
2Synaptic vesicle cycle_Homo sapiens_hsa047212.51237143
3Long-term potentiation_Homo sapiens_hsa047202.49814444
4Olfactory transduction_Homo sapiens_hsa047402.41228089
5Circadian entrainment_Homo sapiens_hsa047132.32071400
6Amphetamine addiction_Homo sapiens_hsa050312.14593909
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14122730
8Salivary secretion_Homo sapiens_hsa049702.09599835
9Glutamatergic synapse_Homo sapiens_hsa047242.08094513
10GABAergic synapse_Homo sapiens_hsa047272.04392224
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04153684
12Morphine addiction_Homo sapiens_hsa050322.03283658
13Insulin secretion_Homo sapiens_hsa049111.90726336
14Gastric acid secretion_Homo sapiens_hsa049711.90195460
15Dopaminergic synapse_Homo sapiens_hsa047281.83006738
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80358158
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.77688272
18Cholinergic synapse_Homo sapiens_hsa047251.72336622
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67494534
20Renin secretion_Homo sapiens_hsa049241.64317640
21Type II diabetes mellitus_Homo sapiens_hsa049301.60588792
22Oxytocin signaling pathway_Homo sapiens_hsa049211.57974245
23Glioma_Homo sapiens_hsa052141.42159550
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41253020
25Calcium signaling pathway_Homo sapiens_hsa040201.41107258
26Nitrogen metabolism_Homo sapiens_hsa009101.40110553
27GnRH signaling pathway_Homo sapiens_hsa049121.39800023
28Taste transduction_Homo sapiens_hsa047421.38858741
29Cocaine addiction_Homo sapiens_hsa050301.37052730
30Estrogen signaling pathway_Homo sapiens_hsa049151.33907471
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33592303
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30597718
33Long-term depression_Homo sapiens_hsa047301.30407582
34Gap junction_Homo sapiens_hsa045401.27876986
35Vitamin B6 metabolism_Homo sapiens_hsa007501.27294093
36Dorso-ventral axis formation_Homo sapiens_hsa043201.22707156
37cAMP signaling pathway_Homo sapiens_hsa040241.21764463
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21594901
39ErbB signaling pathway_Homo sapiens_hsa040121.20359000
40Arginine biosynthesis_Homo sapiens_hsa002201.20266097
41mTOR signaling pathway_Homo sapiens_hsa041501.17134498
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14437428
43Melanogenesis_Homo sapiens_hsa049161.10727928
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06211610
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03616674
46Serotonergic synapse_Homo sapiens_hsa047261.02507384
47Thyroid cancer_Homo sapiens_hsa052161.02503689
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00617312
49Lysine degradation_Homo sapiens_hsa003100.99630188
50Axon guidance_Homo sapiens_hsa043600.96929502
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96259358
52Dilated cardiomyopathy_Homo sapiens_hsa054140.95393685
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.91807055
54Endometrial cancer_Homo sapiens_hsa052130.89768199
55Oocyte meiosis_Homo sapiens_hsa041140.89454422
56Pancreatic secretion_Homo sapiens_hsa049720.89054953
57Thyroid hormone synthesis_Homo sapiens_hsa049180.88730050
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85556697
59Choline metabolism in cancer_Homo sapiens_hsa052310.85305795
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.84811230
61FoxO signaling pathway_Homo sapiens_hsa040680.84688052
62Non-small cell lung cancer_Homo sapiens_hsa052230.83422406
63Glucagon signaling pathway_Homo sapiens_hsa049220.82851084
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.82839798
65VEGF signaling pathway_Homo sapiens_hsa043700.81804958
66Bile secretion_Homo sapiens_hsa049760.81512540
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79011181
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77732928
69Prostate cancer_Homo sapiens_hsa052150.76118408
70MAPK signaling pathway_Homo sapiens_hsa040100.75390115
71Insulin signaling pathway_Homo sapiens_hsa049100.75088626
72Inositol phosphate metabolism_Homo sapiens_hsa005620.74181150
73Rap1 signaling pathway_Homo sapiens_hsa040150.73841879
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70282561
75MicroRNAs in cancer_Homo sapiens_hsa052060.68117663
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66275595
77Collecting duct acid secretion_Homo sapiens_hsa049660.65200327
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.64737249
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63629885
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.62955297
81Pancreatic cancer_Homo sapiens_hsa052120.62338764
82Alcoholism_Homo sapiens_hsa050340.61735366
83Renal cell carcinoma_Homo sapiens_hsa052110.59385753
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59152282
85Notch signaling pathway_Homo sapiens_hsa043300.57240703
86Tight junction_Homo sapiens_hsa045300.56842267
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55069847
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54865998
89Ras signaling pathway_Homo sapiens_hsa040140.52760069
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52557762
91Focal adhesion_Homo sapiens_hsa045100.52203450
92Histidine metabolism_Homo sapiens_hsa003400.51795545
93Wnt signaling pathway_Homo sapiens_hsa043100.51146473
94Acute myeloid leukemia_Homo sapiens_hsa052210.50069288
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49425370
96ABC transporters_Homo sapiens_hsa020100.48484616
97Mineral absorption_Homo sapiens_hsa049780.48313916
98Endocytosis_Homo sapiens_hsa041440.47644433
99Cardiac muscle contraction_Homo sapiens_hsa042600.47515986
100Prolactin signaling pathway_Homo sapiens_hsa049170.47405738
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47124013
102Adherens junction_Homo sapiens_hsa045200.47074364
103Insulin resistance_Homo sapiens_hsa049310.47028529
104Fatty acid biosynthesis_Homo sapiens_hsa000610.45628173
105Circadian rhythm_Homo sapiens_hsa047100.45498067
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45335268
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44837999
108Colorectal cancer_Homo sapiens_hsa052100.44174209
109AMPK signaling pathway_Homo sapiens_hsa041520.44091458
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.42077026
111Chronic myeloid leukemia_Homo sapiens_hsa052200.42038366
112Proteoglycans in cancer_Homo sapiens_hsa052050.42014444
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41803668
114Hippo signaling pathway_Homo sapiens_hsa043900.41044154
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40993575
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40843959
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40434218
118Chemokine signaling pathway_Homo sapiens_hsa040620.39135603

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