LMX1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)9.25746342
2glomerular epithelial cell development (GO:0072310)9.12964096
3glomerular basement membrane development (GO:0032836)8.69212209
4* dopaminergic neuron differentiation (GO:0071542)7.16702108
5negative regulation of axon guidance (GO:1902668)6.51574955
6negative regulation of mesenchymal cell apoptotic process (GO:2001054)6.43691362
7regulation of mesenchymal cell apoptotic process (GO:2001053)6.13831808
8cell proliferation involved in metanephros development (GO:0072203)6.09768648
9regulation of axon guidance (GO:1902667)5.48780523
10glomerulus development (GO:0032835)5.35406235
11otic vesicle formation (GO:0030916)5.09600657
12paraxial mesoderm development (GO:0048339)4.96657461
13negative regulation of axon extension involved in axon guidance (GO:0048843)4.86437872
14branching involved in salivary gland morphogenesis (GO:0060445)4.79303056
15axon extension involved in axon guidance (GO:0048846)4.53226188
16neuron projection extension involved in neuron projection guidance (GO:1902284)4.53226188
17primitive streak formation (GO:0090009)4.48126261
18mesenchymal cell proliferation (GO:0010463)4.45935923
19lung epithelium development (GO:0060428)4.44158119
20* midbrain development (GO:0030901)4.42147537
21regulation of axon extension involved in axon guidance (GO:0048841)4.35992349
22embryonic foregut morphogenesis (GO:0048617)4.34086501
23positive regulation of gastrulation (GO:2000543)4.28330545
24limb bud formation (GO:0060174)4.24880913
25lateral sprouting from an epithelium (GO:0060601)4.23367958
26cell proliferation involved in kidney development (GO:0072111)4.22998310
27planar cell polarity pathway involved in neural tube closure (GO:0090179)4.14983672
28camera-type eye morphogenesis (GO:0048593)4.14849652
29mesonephros development (GO:0001823)4.10537187
30mesenchymal-epithelial cell signaling (GO:0060638)4.07781753
31artery development (GO:0060840)4.07003864
32embryonic camera-type eye development (GO:0031076)4.05871880
33thalamus development (GO:0021794)4.00083749
34cornea development in camera-type eye (GO:0061303)3.98436935
35lung-associated mesenchyme development (GO:0060484)3.93141586
36kidney morphogenesis (GO:0060993)3.91631710
37establishment of planar polarity (GO:0001736)3.91402129
38establishment of tissue polarity (GO:0007164)3.91402129
39astrocyte differentiation (GO:0048708)3.90682516
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.88971922
41regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.79449264
42positive regulation of oligodendrocyte differentiation (GO:0048714)3.79294488
43regulation of organ formation (GO:0003156)3.72944874
44positive regulation of protein kinase C signaling (GO:0090037)3.66406568
45epithelial cell differentiation involved in kidney development (GO:0035850)3.65916497
46dorsal/ventral neural tube patterning (GO:0021904)3.65873324
47non-canonical Wnt signaling pathway (GO:0035567)3.65019451
48regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.63466209
49regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.61055368
50hindbrain development (GO:0030902)3.54027677
51myotube differentiation (GO:0014902)3.52752649
52neuronal ion channel clustering (GO:0045161)3.52292910
53behavioral response to nicotine (GO:0035095)3.49804183
54negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.48002084
55skeletal muscle adaptation (GO:0043501)3.46082582
56ear development (GO:0043583)3.43760677
57axonal fasciculation (GO:0007413)3.42620847
58pattern specification involved in kidney development (GO:0061004)3.41704031
59somite development (GO:0061053)3.39824430
60pyrimidine nucleobase catabolic process (GO:0006208)3.39057549
61regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.38971865
62positive regulation of embryonic development (GO:0040019)3.37812822
63lens fiber cell development (GO:0070307)3.37775711
64neuron fate determination (GO:0048664)3.37760265
65lung lobe morphogenesis (GO:0060463)3.29273089
66cardiac right ventricle morphogenesis (GO:0003215)3.28967786
67cell migration in hindbrain (GO:0021535)3.26555826
68positive regulation of neuroblast proliferation (GO:0002052)3.24000704
69lung secretory cell differentiation (GO:0061140)3.22727274
70dendritic spine morphogenesis (GO:0060997)3.21135609
71negative regulation of smooth muscle cell differentiation (GO:0051151)3.19841277
72negative chemotaxis (GO:0050919)3.17150760
73renal filtration (GO:0097205)3.17087495
74negative regulation of axon extension (GO:0030517)3.08733811
75metanephros development (GO:0001656)3.08090833
76axis elongation (GO:0003401)3.07853687
77negative regulation of DNA-templated transcription, elongation (GO:0032785)3.07094575
78negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.07094575
79negative regulation of kidney development (GO:0090185)3.06541725
80prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.05797367
81cell migration involved in heart development (GO:0060973)3.05072142
82startle response (GO:0001964)3.04276148
83cochlea morphogenesis (GO:0090103)3.03154830
84regulation of cell proliferation involved in kidney development (GO:1901722)3.03132278
85embryonic hindlimb morphogenesis (GO:0035116)3.01579567
86ectoderm development (GO:0007398)3.01378578
87branching involved in ureteric bud morphogenesis (GO:0001658)3.00864810
88adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.98725467
89neuronal stem cell maintenance (GO:0097150)2.98498687
90epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.96227925
91hindlimb morphogenesis (GO:0035137)2.95835289
92positive regulation of smoothened signaling pathway (GO:0045880)2.95334989
93cardiovascular system development (GO:0072358)2.95019366
94nephron tubule morphogenesis (GO:0072078)2.92257303
95nephron epithelium morphogenesis (GO:0072088)2.92257303
96establishment of nucleus localization (GO:0040023)2.89152748
97branch elongation of an epithelium (GO:0060602)2.87724030
98myoblast fusion (GO:0007520)2.87013850
99renal system development (GO:0072001)2.86943310
100urinary tract smooth muscle contraction (GO:0014848)2.86478396
101osteoblast development (GO:0002076)2.85970008
102neuron recognition (GO:0008038)2.85922132
103embryonic forelimb morphogenesis (GO:0035115)2.85265039
104regulation of mesoderm development (GO:2000380)2.84055010
105neuron maturation (GO:0042551)2.83678240
106apical protein localization (GO:0045176)2.83593871
107embryonic skeletal system development (GO:0048706)2.82389355
108male genitalia development (GO:0030539)2.82386155
109Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.81550090
110face development (GO:0060324)2.81400040
111embryonic retina morphogenesis in camera-type eye (GO:0060059)2.81082366
112positive regulation of mesenchymal cell proliferation (GO:0002053)2.80992422
113positive regulation of BMP signaling pathway (GO:0030513)2.80243117
114negative regulation of chemotaxis (GO:0050922)2.80243096
115outer ear morphogenesis (GO:0042473)2.80101428
116neuron fate specification (GO:0048665)2.79112220
117convergent extension (GO:0060026)2.78406254
118retinal ganglion cell axon guidance (GO:0031290)2.78345012
119negative regulation of embryonic development (GO:0045992)2.76485592
120forelimb morphogenesis (GO:0035136)2.74769708
121negative regulation of microtubule polymerization (GO:0031115)2.74705297
122regulation of oligodendrocyte differentiation (GO:0048713)2.73604682
123* organ growth (GO:0035265)2.73409514
124mesenchyme development (GO:0060485)2.72139449
125midgut development (GO:0007494)2.72058351
126negative regulation of Rho protein signal transduction (GO:0035024)2.71577447
127regulation of establishment of planar polarity (GO:0090175)2.71518311
128peripheral nervous system axon ensheathment (GO:0032292)2.70892780
129myelination in peripheral nervous system (GO:0022011)2.70892780
130nucleobase catabolic process (GO:0046113)2.70546074
131glomerular filtration (GO:0003094)2.69599524
132prostate gland growth (GO:0060736)2.67220279
133prostate gland epithelium morphogenesis (GO:0060740)2.66616909
134radial glial cell differentiation (GO:0060019)2.65094864
135bicarbonate transport (GO:0015701)2.64864220
136neuron remodeling (GO:0016322)2.64529878
137retina layer formation (GO:0010842)2.63820069
138embryonic body morphogenesis (GO:0010172)2.63185513
139positive regulation of fatty acid beta-oxidation (GO:0032000)2.63015568
140neural crest cell migration (GO:0001755)2.61888963
141cell-cell signaling involved in cell fate commitment (GO:0045168)2.61386685
142white fat cell differentiation (GO:0050872)2.59753230
143organ induction (GO:0001759)2.59737390
144sympathetic nervous system development (GO:0048485)2.59472782
145positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.56375515
146embryonic digestive tract morphogenesis (GO:0048557)2.53149321
147RNA localization (GO:0006403)2.52283559
148positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.48573486
149body morphogenesis (GO:0010171)2.47958112
150innervation (GO:0060384)2.47196762
151cardiac muscle cell proliferation (GO:0060038)2.44530798
152synapse assembly (GO:0007416)2.43818058
153determination of left/right symmetry (GO:0007368)2.42438424
154epithelial cilium movement (GO:0003351)2.40311225
155cochlea development (GO:0090102)2.40260639
156developmental induction (GO:0031128)2.38606667
157regulation of keratinocyte proliferation (GO:0010837)2.37436853
158regulation of glycogen (starch) synthase activity (GO:2000465)2.35633770
159inner ear receptor stereocilium organization (GO:0060122)2.35423080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.42271485
2EED_16625203_ChIP-ChIP_MESCs_Mouse3.49031668
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04920047
4* EZH2_27304074_Chip-Seq_ESCs_Mouse3.03532885
5* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.99849396
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.99849396
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98293236
8* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.95832796
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.95614636
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.83521204
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81439077
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.80381935
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.70994296
14* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67345152
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.59365688
16* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.57751082
17* TP63_19390658_ChIP-ChIP_HaCaT_Human2.52000475
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.50692936
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46338985
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37564510
21* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.33504141
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.29760228
23* TP53_20018659_ChIP-ChIP_R1E_Mouse2.28550793
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.28200175
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.26509584
26ESR1_20079471_ChIP-ChIP_T-47D_Human2.21217169
27TRIM28_21343339_ChIP-Seq_HEK293_Human2.20916632
28* CBX2_27304074_Chip-Seq_ESCs_Mouse2.18568430
29VDR_22108803_ChIP-Seq_LS180_Human2.16977929
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07114975
31* ERG_21242973_ChIP-ChIP_JURKAT_Human2.05653230
32OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.96095158
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94829577
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94132291
35* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93447547
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88659265
37* RING1B_27294783_Chip-Seq_NPCs_Mouse1.85588600
38* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83622177
39* RING1B_27294783_Chip-Seq_ESCs_Mouse1.79303754
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75664964
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67265490
42* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65645822
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65410431
44GBX2_23144817_ChIP-Seq_PC3_Human1.65064775
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.64203472
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60521898
47* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.58975475
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53201957
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52048763
50* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51349201
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42849061
52ER_23166858_ChIP-Seq_MCF-7_Human1.41809416
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.41477493
54* RNF2_27304074_Chip-Seq_NSC_Mouse1.41063767
55* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40473827
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.35324661
57* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33862536
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32720801
59DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32684239
60AHR_22903824_ChIP-Seq_MCF-7_Human1.31613938
61* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31066716
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27568341
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22826595
64* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22188245
65EWS_26573619_Chip-Seq_HEK293_Human1.20988050
66AR_21572438_ChIP-Seq_LNCaP_Human1.20954206
67* DROSHA_22980978_ChIP-Seq_HELA_Human1.18424712
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16414455
69* KDM2B_26808549_Chip-Seq_K562_Human1.16223565
70* RUNX1_27514584_Chip-Seq_MCF-7_Human1.12390726
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.12301135
72* PIAS1_25552417_ChIP-Seq_VCAP_Human1.12020873
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11387754
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11357252
75* ZNF274_21170338_ChIP-Seq_K562_Hela1.10411037
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09782698
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.09152840
78* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08574174
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06374554
80CTCF_27219007_Chip-Seq_Bcells_Human1.05605028
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04892581
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04345919
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04011954
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03621427
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01909151
86* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00709499
87* AR_19668381_ChIP-Seq_PC3_Human0.99776580
88TAF15_26573619_Chip-Seq_HEK293_Human0.98981521
89REST_21632747_ChIP-Seq_MESCs_Mouse0.98752592
90EP300_21415370_ChIP-Seq_HL-1_Mouse0.98517446
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.98134281
92* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97063491
93REST_18959480_ChIP-ChIP_MESCs_Mouse0.96058951
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95255816
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.94776190
96TP53_18474530_ChIP-ChIP_U2OS_Human0.94669268
97* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94579458
98* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94309652
99RXR_22108803_ChIP-Seq_LS180_Human0.93696214
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93628880
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92391333
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92075997
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91831789
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91831789
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91831789
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91454942
107CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91198978
108P300_19829295_ChIP-Seq_ESCs_Human0.90134125
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89397190
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88715501
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88142154
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87588320
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87325289
114* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86946301
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86648987
116* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86595607
117SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86007316
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.85114122
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84970311
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84855524
121* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84577114
122TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83576093
123ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83508866
124* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81967265
125* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81967265
126FUS_26573619_Chip-Seq_HEK293_Human0.79814583
127* KLF5_25053715_ChIP-Seq_YYC3_Human0.79751660
128CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79548666
129GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77801576
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.77700328
131* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77527684
132* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.77281314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ6.11354241
2MP0003878_abnormal_ear_physiology5.81777515
3MP0005377_hearing/vestibular/ear_phenot5.81777515
4MP0009053_abnormal_anal_canal5.14268029
5MP0000566_synostosis3.68993603
6MP0010030_abnormal_orbit_morphology3.61423271
7MP0000537_abnormal_urethra_morphology3.28460948
8MP0002102_abnormal_ear_morphology2.98585941
9MP0002234_abnormal_pharynx_morphology2.98094505
10MP0004885_abnormal_endolymph2.95543742
11MP0003122_maternal_imprinting2.90759248
12MP0002653_abnormal_ependyma_morphology2.71668508
13MP0003942_abnormal_urinary_system2.64258689
14MP0005187_abnormal_penis_morphology2.50223716
15MP0002282_abnormal_trachea_morphology2.36009899
16MP0005623_abnormal_meninges_morphology2.32457049
17MP0000534_abnormal_ureter_morphology2.26056972
18* MP0003937_abnormal_limbs/digits/tail_de2.00496780
19MP0003938_abnormal_ear_development1.98683303
20MP0000778_abnormal_nervous_system1.98262198
21MP0008961_abnormal_basal_metabolism1.97227751
22MP0003315_abnormal_perineum_morphology1.88496586
23MP0000569_abnormal_digit_pigmentation1.86240972
24MP0000462_abnormal_digestive_system1.84657989
25MP0006276_abnormal_autonomic_nervous1.79596119
26MP0004272_abnormal_basement_membrane1.77488840
27* MP0002932_abnormal_joint_morphology1.72250081
28MP0002233_abnormal_nose_morphology1.68125070
29MP0003385_abnormal_body_wall1.67919543
30MP0003115_abnormal_respiratory_system1.66096303
31MP0003119_abnormal_digestive_system1.65465296
32MP0000049_abnormal_middle_ear1.63824805
33MP0004133_heterotaxia1.63333568
34MP0003123_paternal_imprinting1.63287452
35MP0001968_abnormal_touch/_nociception1.59282835
36MP0000383_abnormal_hair_follicle1.58307626
37MP0002751_abnormal_autonomic_nervous1.56986188
38MP0001299_abnormal_eye_distance/1.53402090
39MP0002736_abnormal_nociception_after1.50301068
40MP0002277_abnormal_respiratory_mucosa1.42663764
41MP0003121_genomic_imprinting1.42450510
42MP0003890_abnormal_embryonic-extraembry1.40812764
43MP0000428_abnormal_craniofacial_morphol1.38671957
44MP0002938_white_spotting1.38190308
45MP0006072_abnormal_retinal_apoptosis1.37483170
46MP0002249_abnormal_larynx_morphology1.36179348
47* MP0002116_abnormal_craniofacial_bone1.32353939
48MP0000538_abnormal_urinary_bladder1.30806129
49MP0010678_abnormal_skin_adnexa1.27514500
50MP0005646_abnormal_pituitary_gland1.27397938
51MP0000427_abnormal_hair_cycle1.26358639
52* MP0000579_abnormal_nail_morphology1.25602937
53MP0003755_abnormal_palate_morphology1.24638148
54MP0001293_anophthalmia1.24040188
55MP0001346_abnormal_lacrimal_gland1.21129642
56* MP0009250_abnormal_appendicular_skeleto1.21062082
57MP0001286_abnormal_eye_development1.18491691
58* MP0003861_abnormal_nervous_system1.18014075
59MP0003880_abnormal_central_pattern1.17282033
60MP0004859_abnormal_synaptic_plasticity1.15684966
61* MP0002697_abnormal_eye_size1.15213695
62MP0000026_abnormal_inner_ear1.15154006
63MP0003935_abnormal_craniofacial_develop1.12051926
64MP0004264_abnormal_extraembryonic_tissu1.11220732
65MP0005423_abnormal_somatic_nervous1.10219978
66MP0002092_abnormal_eye_morphology1.09776385
67MP0000631_abnormal_neuroendocrine_gland1.06908815
68* MP0002572_abnormal_emotion/affect_behav1.06890969
69MP0000467_abnormal_esophagus_morphology1.05645234
70MP0002177_abnormal_outer_ear1.03318762
71MP0001502_abnormal_circadian_rhythm1.03173007
72MP0001529_abnormal_vocalization0.99957618
73* MP0005508_abnormal_skeleton_morphology0.97520290
74* MP0002184_abnormal_innervation0.96559027
75MP0001963_abnormal_hearing_physiology0.92826577
76MP0000955_abnormal_spinal_cord0.91480647
77* MP0002109_abnormal_limb_morphology0.90740755
78MP0000762_abnormal_tongue_morphology0.89741291
79MP0002098_abnormal_vibrissa_morphology0.88945233
80MP0000647_abnormal_sebaceous_gland0.88851431
81MP0002928_abnormal_bile_duct0.87612847
82MP0001340_abnormal_eyelid_morphology0.87340182
83MP0001486_abnormal_startle_reflex0.86814896
84MP0003091_abnormal_cell_migration0.86603027
85MP0002114_abnormal_axial_skeleton0.85700621
86MP0009745_abnormal_behavioral_response0.84754234
87MP0002822_catalepsy0.84655844
88* MP0002085_abnormal_embryonic_tissue0.84027701
89* MP0002084_abnormal_developmental_patter0.83996279
90* MP0000163_abnormal_cartilage_morphology0.83135658
91* MP0002152_abnormal_brain_morphology0.82833274
92MP0005248_abnormal_Harderian_gland0.82728511
93* MP0002081_perinatal_lethality0.82406201
94MP0005257_abnormal_intraocular_pressure0.82361393
95MP0001849_ear_inflammation0.82279486
96MP0002735_abnormal_chemical_nociception0.81026483
97MP0003936_abnormal_reproductive_system0.79806229
98MP0001485_abnormal_pinna_reflex0.79330270
99MP0003787_abnormal_imprinting0.77840443
100MP0005391_vision/eye_phenotype0.77786219
101* MP0002752_abnormal_somatic_nervous0.77572914
102MP0002272_abnormal_nervous_system0.77479121
103MP0002111_abnormal_tail_morphology0.74302980
104* MP0002115_abnormal_skeleton_extremities0.74300875
105MP0008995_early_reproductive_senescence0.74136339
106MP0002557_abnormal_social/conspecific_i0.73622313
107MP0000613_abnormal_salivary_gland0.73253649
108MP0000432_abnormal_head_morphology0.73225193
109* MP0005197_abnormal_uvea_morphology0.72664263
110* MP0002113_abnormal_skeleton_development0.71820341
111MP0001324_abnormal_eye_pigmentation0.70700459
112MP0001188_hyperpigmentation0.70510029
113MP0002909_abnormal_adrenal_gland0.70235599
114MP0002009_preneoplasia0.69538096
115MP0002067_abnormal_sensory_capabilities0.69421933
116MP0001501_abnormal_sleep_pattern0.69078181
117MP0003137_abnormal_impulse_conducting0.68985993
118* MP0003635_abnormal_synaptic_transmissio0.68983887
119MP0004381_abnormal_hair_follicle0.68911775
120MP0002734_abnormal_mechanical_nocicepti0.68877570
121MP0001905_abnormal_dopamine_level0.68853311
122MP0008872_abnormal_physiological_respon0.68457909
123MP0005076_abnormal_cell_differentiation0.67517604
124MP0000733_abnormal_muscle_development0.66126502
125MP0000470_abnormal_stomach_morphology0.65927388
126MP0005253_abnormal_eye_physiology0.65218829
127MP0004742_abnormal_vestibular_system0.64453284
128* MP0005503_abnormal_tendon_morphology0.63134112
129MP0004145_abnormal_muscle_electrophysio0.61271406
130* MP0002063_abnormal_learning/memory/cond0.61001958
131MP0001879_abnormal_lymphatic_vessel0.60426848
132MP0004197_abnormal_fetal_growth/weight/0.60134452
133* MP0002882_abnormal_neuron_morphology0.60134114

Predicted human phenotypes

RankGene SetZ-score
1Focal segmental glomerulosclerosis (HP:0000097)5.05960080
2Mesangial abnormality (HP:0001966)5.01483518
3Renal duplication (HP:0000075)4.55084044
4Short middle phalanx of the 5th finger (HP:0004220)4.53320855
5Aplasia involving bones of the extremities (HP:0009825)4.50606245
6Aplasia involving bones of the upper limbs (HP:0009823)4.50606245
7Aplasia of the phalanges of the hand (HP:0009802)4.50606245
8Glomerulosclerosis (HP:0000096)3.90491922
9Bilateral microphthalmos (HP:0007633)3.62209364
10Short 5th finger (HP:0009237)3.59999886
11Hypoalbuminemia (HP:0003073)3.53577247
12Abnormal albumin level (HP:0012116)3.53577247
13Partial duplication of thumb phalanx (HP:0009944)3.53384855
14Partial duplication of the phalanx of hand (HP:0009999)3.46737870
15Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.44245485
16Abnormal number of incisors (HP:0011064)3.32488392
17* Concave nail (HP:0001598)3.31089921
18Anophthalmia (HP:0000528)3.16966548
19Alacrima (HP:0000522)3.16647004
20Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.15617401
21Mesomelia (HP:0003027)3.13920929
22Pancreatic cysts (HP:0001737)3.04622581
23Narrow nasal bridge (HP:0000446)3.03393413
24Type II lissencephaly (HP:0007260)2.99768245
25Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.91885338
26Tubular atrophy (HP:0000092)2.91306382
27Stage 5 chronic kidney disease (HP:0003774)2.88827030
28Maternal diabetes (HP:0009800)2.88223038
29Preaxial foot polydactyly (HP:0001841)2.87080824
30Midline defect of the nose (HP:0004122)2.85417337
31Anterior segment dysgenesis (HP:0007700)2.84315206
32Down-sloping shoulders (HP:0200021)2.83853785
33Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.81686212
34Growth hormone deficiency (HP:0000824)2.80934416
35Nephronophthisis (HP:0000090)2.75481195
36Abnormality of the lacrimal duct (HP:0011481)2.73406519
37Lymphangioma (HP:0100764)2.71451526
38Labial hypoplasia (HP:0000066)2.69340421
39Abnormality of incisor morphology (HP:0011063)2.69062211
40Esophageal atresia (HP:0002032)2.66101096
41Anosmia (HP:0000458)2.65578328
42Abnormality of the phalanges of the 5th finger (HP:0004213)2.63768100
43Abnormality of the parathyroid morphology (HP:0011766)2.61345304
44Septate vagina (HP:0001153)2.59298799
45Abnormality of midbrain morphology (HP:0002418)2.58192503
46Molar tooth sign on MRI (HP:0002419)2.58192503
47Broad thumb (HP:0011304)2.57033371
48Conical tooth (HP:0000698)2.56216377
49Nasolacrimal duct obstruction (HP:0000579)2.55825324
50True hermaphroditism (HP:0010459)2.50105992
51Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.48804780
52Abnormality of the nasolacrimal system (HP:0000614)2.47756511
53Limb dystonia (HP:0002451)2.45309101
54Abnormality of chromosome segregation (HP:0002916)2.44866323
55Agitation (HP:0000713)2.43257874
56Decreased lacrimation (HP:0000633)2.43242519
57Tented upper lip vermilion (HP:0010804)2.40096678
58Broad hallux (HP:0010055)2.39965018
59Hypoplastic female external genitalia (HP:0012815)2.37752496
60Abnormality of permanent molar morphology (HP:0011071)2.36986000
61Abnormality of the dental root (HP:0006486)2.36986000
62Taurodontia (HP:0000679)2.36986000
63Oligodactyly (hands) (HP:0001180)2.35750405
64Anomalous pulmonary venous return (HP:0010772)2.34539369
65Corneal erosion (HP:0200020)2.30195605
66Cystic liver disease (HP:0006706)2.28626936
67Pancreatic fibrosis (HP:0100732)2.27786227
68Anal stenosis (HP:0002025)2.26368615
69Abnormality of the 4th metacarpal (HP:0010012)2.23186906
70Recurrent corneal erosions (HP:0000495)2.22621506
71Abnormality of the renal medulla (HP:0100957)2.21482770
72Abnormality of molar morphology (HP:0011070)2.17654695
73Abnormality of molar (HP:0011077)2.17654695
74Oligodactyly (HP:0012165)2.17107775
75Abnormality of the incisor (HP:0000676)2.16454373
76Bifid tongue (HP:0010297)2.16257668
77Bicornuate uterus (HP:0000813)2.14825248
78Mixed hearing impairment (HP:0000410)2.14416854
79Intestinal atresia (HP:0011100)2.13925189
80Fibular aplasia (HP:0002990)2.13779514
81Deviation of the hallux (HP:0010051)2.13551651
82Cerebellar dysplasia (HP:0007033)2.11551582
83Chin dimple (HP:0010751)2.11424732
84Abnormality of the dental pulp (HP:0006479)2.10612780
85Congenital glaucoma (HP:0001087)2.08503748
86High anterior hairline (HP:0009890)2.07553623
87Hepatoblastoma (HP:0002884)2.07111182
88Broad toe (HP:0001837)2.06112775
89Hypoplastic labia majora (HP:0000059)2.05650961
90Abnormality of the parietal bone (HP:0002696)2.05159447
91Preaxial hand polydactyly (HP:0001177)2.04648705
92Hyperacusis (HP:0010780)2.04297515
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02800697
94Humeroradial synostosis (HP:0003041)2.00189609
95Synostosis involving the elbow (HP:0003938)2.00189609
96Shawl scrotum (HP:0000049)1.99679801
97Aqueductal stenosis (HP:0002410)1.98822330
98Coronal craniosynostosis (HP:0004440)1.97908536
99Broad phalanges of the hand (HP:0009768)1.97231872
100Nonprogressive disorder (HP:0003680)1.96761711
101Bifid scrotum (HP:0000048)1.96379815
102Exotropia (HP:0000577)1.96059394
103Short middle phalanx of finger (HP:0005819)1.95694710
104Abnormality of the intervertebral disk (HP:0005108)1.95026746
105Abnormal respiratory epithelium morphology (HP:0012253)1.94368935
106Abnormal respiratory motile cilium morphology (HP:0005938)1.94368935
107Focal motor seizures (HP:0011153)1.94332554
108Deep palmar crease (HP:0006191)1.94103858
109Shallow orbits (HP:0000586)1.93378161
110Hyperventilation (HP:0002883)1.92762702
111Occipital encephalocele (HP:0002085)1.91160612
112Hallux valgus (HP:0001822)1.91139338
113Abnormality of the right ventricle (HP:0001707)1.90374772
114Abnormality of the pulmonary veins (HP:0011718)1.89833725
115Enlarged penis (HP:0000040)1.89121953
116Overriding aorta (HP:0002623)1.89000611
117Hypothermia (HP:0002045)1.88817444
118Buphthalmos (HP:0000557)1.87947665
119Chronic hepatic failure (HP:0100626)1.87912099
120Broad finger (HP:0001500)1.86898117
121Lissencephaly (HP:0001339)1.86034312
122Pheochromocytoma (HP:0002666)1.85674793
123Hypoplasia of the ulna (HP:0003022)1.83804427
124Cutaneous finger syndactyly (HP:0010554)1.83759134
125Chorioretinal coloboma (HP:0000567)1.83251573
126Abnormality of the pubic bones (HP:0003172)1.82309592
127Abnormality of the labia majora (HP:0012881)1.81804427
128Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.80971094
129Short 1st metacarpal (HP:0010034)1.80971094
130Hyperthyroidism (HP:0000836)1.80038873
131Vesicoureteral reflux (HP:0000076)1.78421511
132Hypoparathyroidism (HP:0000829)1.78379048
133* Patellar aplasia (HP:0006443)1.78094634
134Hypoplastic ischia (HP:0003175)1.77989951
135* Nephrotic syndrome (HP:0000100)1.77575139
136Renal dysplasia (HP:0000110)1.77438941
137Hypodontia (HP:0000668)1.77255128
138Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76861801
139Short 4th metacarpal (HP:0010044)1.76861801
140Aplasia/Hypoplasia of the ulna (HP:0006495)1.76784659
141Broad phalanx (HP:0006009)1.76378454
142Meningocele (HP:0002435)1.76182254
143Turricephaly (HP:0000262)1.75654248
144Bronchomalacia (HP:0002780)1.75580546
145Metaphyseal dysplasia (HP:0100255)1.75380308
146Symphalangism affecting the phalanges of the hand (HP:0009773)1.75367387
147* Aplasia/Hypoplasia of the patella (HP:0006498)1.74721717
148Pendular nystagmus (HP:0012043)1.74532263
149Hydronephrosis (HP:0000126)1.73478725
150Abnormality of the labia minora (HP:0012880)1.73217368
151Duplication of thumb phalanx (HP:0009942)1.73052146
152Ectopic kidney (HP:0000086)1.72524232
153Rapidly progressive (HP:0003678)1.71903150
154Long palpebral fissure (HP:0000637)1.71077320
155Infantile muscular hypotonia (HP:0008947)1.70688792
156Absent radius (HP:0003974)1.70471393
157Abnormality of the middle phalanges of the toes (HP:0010183)1.69786017
158Neoplasm of the heart (HP:0100544)1.69518945
159Gastrointestinal atresia (HP:0002589)1.69100946
160Elfin facies (HP:0004428)1.68679651
161Megalocornea (HP:0000485)1.68554652
162Aplasia involving forearm bones (HP:0009822)1.68344688
163Absent forearm bone (HP:0003953)1.68344688
164Abnormality of the 2nd finger (HP:0004100)1.67932657
165Hypoplasia of the pons (HP:0012110)1.67774213
166Ulnar deviation of finger (HP:0009465)1.67045012
167Abnormality of the labia (HP:0000058)1.66905438
168Retinal dysplasia (HP:0007973)1.66738677
169Sclerocornea (HP:0000647)1.66653955
170Septo-optic dysplasia (HP:0100842)1.66586264
171Ulnar claw (HP:0001178)1.66249471
172* Patellar dislocation (HP:0002999)1.65631903
173Broad long bones (HP:0005622)1.65108577
174Abnormality of the pons (HP:0007361)1.64808977
175Cupped ear (HP:0000378)1.63839079
176Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.63756964
177Broad distal phalanx of finger (HP:0009836)1.62948828
178Morphological abnormality of the inner ear (HP:0011390)1.62899295
179Absent/shortened dynein arms (HP:0200106)1.62373401
180Dynein arm defect of respiratory motile cilia (HP:0012255)1.62373401
181Trigonocephaly (HP:0000243)1.61618274
182Morphological abnormality of the middle ear (HP:0008609)1.61391890
183Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.59389421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB25.16226517
2SIK33.92793173
3KSR13.77518673
4MAPK153.68018537
5CASK3.07529674
6PKN22.77572927
7BCR2.75028280
8FGFR22.65624080
9LATS12.51567783
10MUSK2.45880642
11UHMK12.21681619
12PDGFRA2.11693944
13WNK42.09970371
14MARK12.03592331
15TNIK1.92613255
16MINK11.89591976
17TGFBR11.88347169
18LATS21.87092522
19DYRK31.85787479
20TYRO31.84798022
21IRAK21.83717590
22MAP2K21.81765766
23BUB11.80162109
24NTRK21.76071510
25PASK1.74973901
26CAMK1G1.73969211
27EIF2AK11.69623493
28CDK191.67468671
29PAK31.66995562
30TLK11.65170445
31PAK41.62193303
32ADRBK21.57886359
33ERBB31.57415455
34ICK1.55514182
35FGFR41.53849851
36PNCK1.51347119
37ERBB21.46511367
38MAPKAPK31.41709109
39FER1.41274434
40FGFR11.35507770
41PIK3CA1.32781384
42NTRK31.32122896
43STK38L1.30356310
44TAF11.27693613
45GRK11.26993083
46NTRK11.24594740
47TRIB31.23385013
48CDK181.20801462
49STK391.19559828
50OXSR11.17601239
51CAMK1D1.15293397
52CHUK1.14307422
53CSNK1G31.11642343
54PRKCG1.10837210
55DYRK21.09932001
56MAP2K71.07885007
57AKT21.07239157
58RPS6KA61.03237518
59RPS6KA21.03105925
60DYRK1B1.01426143
61RPS6KB21.00776378
62CDK151.00666577
63CDK140.96797951
64CSNK1G10.96552016
65INSRR0.95764230
66FRK0.95470761
67CDK11A0.94393547
68DDR20.93324264
69NEK10.92781565
70MAPK130.90958124
71CSNK1G20.89135950
72MAP3K100.88997438
73RPS6KC10.88484448
74RPS6KL10.88484448
75LIMK10.86505730
76MAP3K90.85699391
77PAK60.85594446
78RIPK10.83687540
79PRKD30.79129700
80SIK10.78905669
81VRK20.78128493
82MAPK90.76685037
83PTK60.76094967
84CDK30.74697323
85WEE10.74612880
86PHKG20.72120896
87PHKG10.72120896
88CDK80.71686926
89PINK10.71469675
90SRPK10.71206676
91MKNK10.70256794
92EIF2AK20.70061051
93VRK10.69101317
94WNK30.68369125
95PRKCZ0.68197828
96ZAK0.67790389
97MAP2K40.67769202
98PRKCE0.67311411
99ROCK10.66452544
100TAOK30.66270015
101CDK120.64397793
102NEK60.63883920
103MAP3K70.61229971
104CDC70.60595203
105MELK0.59638714
106TRIM280.58620241
107MOS0.58078677
108CAMK2B0.57475288
109PTK20.56500305
110MAP3K60.55285263
111RPS6KA40.55097977
112MAPKAPK50.54725533
113GRK60.53574731
114MAP2K10.52250975
115WNK10.51669695
116PAK20.50993984
117FGFR30.50699786
118CSNK1D0.50277801
119MTOR0.49223013
120IRAK10.48770500
121BRD40.48637571
122ROCK20.48634240
123ADRBK10.47838475
124CDK50.46511197
125CSNK1A1L0.45746032
126CSNK1A10.45516733
127YES10.44612641
128RPS6KB10.44196381
129RPS6KA10.43737236
130MAPK80.43231827
131BCKDK0.42886640
132CAMKK10.42388767
133SIK20.42089580
134ILK0.40629852
135MAPK100.40482371
136DYRK1A0.40470190
137MAP3K40.40091699
138STK110.39651530
139NME10.38796520
140CAMK2A0.38383418
141DMPK0.37877465
142STK380.35916463
143TIE10.35826424
144CSNK1E0.34897863
145CDK70.34771592
146RET0.34645761
147CDC42BPA0.34128597
148TGFBR20.33746143
149SRC0.33129277
150EPHA30.32349186
151BMPR1B0.32109465
152FYN0.30905245
153PRKCI0.30636674
154MAP3K120.28667323
155EPHA20.27054442

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.20140744
2Hedgehog signaling pathway_Homo sapiens_hsa043404.04353533
3Nitrogen metabolism_Homo sapiens_hsa009103.40995603
4Axon guidance_Homo sapiens_hsa043603.09738397
5Hippo signaling pathway_Homo sapiens_hsa043902.76270292
6Phototransduction_Homo sapiens_hsa047442.44368532
7Notch signaling pathway_Homo sapiens_hsa043302.31935986
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.24095446
9Cocaine addiction_Homo sapiens_hsa050302.21248026
10ECM-receptor interaction_Homo sapiens_hsa045122.10764275
11Wnt signaling pathway_Homo sapiens_hsa043102.05657895
12Oxidative phosphorylation_Homo sapiens_hsa001902.03875795
13Melanogenesis_Homo sapiens_hsa049162.01913882
14Cardiac muscle contraction_Homo sapiens_hsa042601.88167534
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83964465
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.74367322
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70916271
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.70034090
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.66018680
20Proteoglycans in cancer_Homo sapiens_hsa052051.59272142
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57798174
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.57069404
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53502200
24Parkinsons disease_Homo sapiens_hsa050121.51044899
25Gap junction_Homo sapiens_hsa045401.50295137
26Linoleic acid metabolism_Homo sapiens_hsa005911.47591864
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36482313
28Renal cell carcinoma_Homo sapiens_hsa052111.35921137
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35628886
30Small cell lung cancer_Homo sapiens_hsa052221.34643321
31Alzheimers disease_Homo sapiens_hsa050101.34469777
32Dopaminergic synapse_Homo sapiens_hsa047281.32896420
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31749244
34Serotonergic synapse_Homo sapiens_hsa047261.30040219
35TGF-beta signaling pathway_Homo sapiens_hsa043501.29753615
36Protein digestion and absorption_Homo sapiens_hsa049741.28518244
37Pathways in cancer_Homo sapiens_hsa052001.27490880
38Amphetamine addiction_Homo sapiens_hsa050311.26619722
39Synaptic vesicle cycle_Homo sapiens_hsa047211.25874323
40Focal adhesion_Homo sapiens_hsa045101.25805503
41MicroRNAs in cancer_Homo sapiens_hsa052061.23293607
42N-Glycan biosynthesis_Homo sapiens_hsa005101.22242470
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19467788
44Bladder cancer_Homo sapiens_hsa052191.19141598
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17489678
46Vibrio cholerae infection_Homo sapiens_hsa051101.16830528
47Sulfur relay system_Homo sapiens_hsa041221.16196339
48Oocyte meiosis_Homo sapiens_hsa041141.14306405
49Insulin secretion_Homo sapiens_hsa049111.13802637
50Nicotine addiction_Homo sapiens_hsa050331.12652659
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10283678
52Basal transcription factors_Homo sapiens_hsa030221.09270994
53Spliceosome_Homo sapiens_hsa030401.08965380
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07388965
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06634216
56Selenocompound metabolism_Homo sapiens_hsa004501.06617251
57Cell cycle_Homo sapiens_hsa041101.06110877
58Colorectal cancer_Homo sapiens_hsa052101.03988632
59Huntingtons disease_Homo sapiens_hsa050161.02653275
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02389071
61Adherens junction_Homo sapiens_hsa045201.02081364
62Chronic myeloid leukemia_Homo sapiens_hsa052200.96455161
63Ovarian steroidogenesis_Homo sapiens_hsa049130.96092732
64Dilated cardiomyopathy_Homo sapiens_hsa054140.94620834
65Protein export_Homo sapiens_hsa030600.92043437
66RNA degradation_Homo sapiens_hsa030180.91760766
67Alcoholism_Homo sapiens_hsa050340.90522978
68Renin-angiotensin system_Homo sapiens_hsa046140.89989935
69ErbB signaling pathway_Homo sapiens_hsa040120.89753932
70Tight junction_Homo sapiens_hsa045300.89534442
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89273443
72Collecting duct acid secretion_Homo sapiens_hsa049660.88621664
73GABAergic synapse_Homo sapiens_hsa047270.88589998
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87580900
75Amoebiasis_Homo sapiens_hsa051460.87353353
76Olfactory transduction_Homo sapiens_hsa047400.87180086
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87028962
78Ether lipid metabolism_Homo sapiens_hsa005650.86200967
79mTOR signaling pathway_Homo sapiens_hsa041500.83114648
80Endometrial cancer_Homo sapiens_hsa052130.83049121
81Glioma_Homo sapiens_hsa052140.82344356
82Rap1 signaling pathway_Homo sapiens_hsa040150.81743467
83HTLV-I infection_Homo sapiens_hsa051660.80237194
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79706551
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78918719
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78901436
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78436354
88Ribosome_Homo sapiens_hsa030100.78200928
89Estrogen signaling pathway_Homo sapiens_hsa049150.76473001
90Lysine degradation_Homo sapiens_hsa003100.75491255
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75440569
92Circadian rhythm_Homo sapiens_hsa047100.75215589
93Glutamatergic synapse_Homo sapiens_hsa047240.74862224
94Taste transduction_Homo sapiens_hsa047420.74842924
95Circadian entrainment_Homo sapiens_hsa047130.74690226
96AMPK signaling pathway_Homo sapiens_hsa041520.73156549
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73101947
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72006029
99Long-term depression_Homo sapiens_hsa047300.71881356
100ABC transporters_Homo sapiens_hsa020100.71034525
101mRNA surveillance pathway_Homo sapiens_hsa030150.70334322
102Tryptophan metabolism_Homo sapiens_hsa003800.70315730
103Butanoate metabolism_Homo sapiens_hsa006500.70082835
104Type II diabetes mellitus_Homo sapiens_hsa049300.68683213
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66686976
106cAMP signaling pathway_Homo sapiens_hsa040240.66133869
107Pancreatic cancer_Homo sapiens_hsa052120.65693848
108Phenylalanine metabolism_Homo sapiens_hsa003600.65419717
109Regulation of autophagy_Homo sapiens_hsa041400.64445987
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63591127
111Melanoma_Homo sapiens_hsa052180.62132107
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62102589
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.61983360
114Non-small cell lung cancer_Homo sapiens_hsa052230.60273583
115Long-term potentiation_Homo sapiens_hsa047200.59919948
116Dorso-ventral axis formation_Homo sapiens_hsa043200.59855161
117Cholinergic synapse_Homo sapiens_hsa047250.59471676
118Morphine addiction_Homo sapiens_hsa050320.57345443
119Choline metabolism in cancer_Homo sapiens_hsa052310.56922655
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56878077
121Renin secretion_Homo sapiens_hsa049240.56386696
122RNA polymerase_Homo sapiens_hsa030200.56353106
123VEGF signaling pathway_Homo sapiens_hsa043700.56221152
124Salivary secretion_Homo sapiens_hsa049700.54245066
125Thyroid hormone synthesis_Homo sapiens_hsa049180.54112234
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53888409
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53812819
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.52853146
129Fanconi anemia pathway_Homo sapiens_hsa034600.51374340
130Oxytocin signaling pathway_Homo sapiens_hsa049210.51329592
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50344898
132MAPK signaling pathway_Homo sapiens_hsa040100.50159233
133Prostate cancer_Homo sapiens_hsa052150.49808565
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49674393
135Phagosome_Homo sapiens_hsa041450.49158387
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48002258
137Histidine metabolism_Homo sapiens_hsa003400.47615299
138GnRH signaling pathway_Homo sapiens_hsa049120.47338765
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46658947
140Ras signaling pathway_Homo sapiens_hsa040140.46639060
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45205438
142Inositol phosphate metabolism_Homo sapiens_hsa005620.45125424
143Calcium signaling pathway_Homo sapiens_hsa040200.44708066
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.44293361

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