LNP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.77344273
2detection of light stimulus involved in visual perception (GO:0050908)7.27960598
3detection of light stimulus involved in sensory perception (GO:0050962)7.27960598
4protein K11-linked deubiquitination (GO:0035871)5.94900907
5protein localization to synapse (GO:0035418)5.74863740
6regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.55679935
7synaptic vesicle exocytosis (GO:0016079)5.43599867
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.32665154
9positive regulation of synapse maturation (GO:0090129)5.27625559
10rhodopsin mediated signaling pathway (GO:0016056)5.26590446
11retinal rod cell development (GO:0046548)5.25142694
12cellular potassium ion homeostasis (GO:0030007)5.11689657
13regulation of short-term neuronal synaptic plasticity (GO:0048172)5.08079123
14G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.06807451
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.96881840
16neurotransmitter-gated ion channel clustering (GO:0072578)4.88096125
17positive regulation of uterine smooth muscle contraction (GO:0070474)4.76288392
18regulation of synaptic vesicle exocytosis (GO:2000300)4.66027105
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.61439926
20tachykinin receptor signaling pathway (GO:0007217)4.59666206
21pyrimidine dimer repair (GO:0006290)4.55402156
22synaptic transmission, glutamatergic (GO:0035249)4.45739959
23gamma-aminobutyric acid signaling pathway (GO:0007214)4.39196922
24neuron-neuron synaptic transmission (GO:0007270)4.33697934
25synaptic vesicle maturation (GO:0016188)4.27680634
26paraxial mesoderm development (GO:0048339)4.21851923
27regulation of synaptic vesicle transport (GO:1902803)4.21525359
28negative regulation of cytosolic calcium ion concentration (GO:0051481)4.18027557
29regulation of catecholamine metabolic process (GO:0042069)4.17090891
30regulation of dopamine metabolic process (GO:0042053)4.17090891
31neuron projection extension involved in neuron projection guidance (GO:1902284)4.15635992
32axon extension involved in axon guidance (GO:0048846)4.15635992
33synaptic vesicle endocytosis (GO:0048488)4.14469712
34positive regulation of synaptic transmission, GABAergic (GO:0032230)4.01745224
35glutamate receptor signaling pathway (GO:0007215)3.95560146
36regulation of voltage-gated calcium channel activity (GO:1901385)3.95027621
37serotonin receptor signaling pathway (GO:0007210)3.94799744
38regulation of uterine smooth muscle contraction (GO:0070472)3.94182285
39regulation of synapse maturation (GO:0090128)3.90453515
40positive regulation of dendritic spine morphogenesis (GO:0061003)3.88508534
41membrane hyperpolarization (GO:0060081)3.86456101
42regulation of rhodopsin mediated signaling pathway (GO:0022400)3.83507291
43glutamate secretion (GO:0014047)3.82355280
44potassium ion homeostasis (GO:0055075)3.78852889
45DNA double-strand break processing (GO:0000729)3.78556894
46innervation (GO:0060384)3.78263157
47negative regulation of axon guidance (GO:1902668)3.76314706
48regulation of chemokine-mediated signaling pathway (GO:0070099)3.68642855
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.68599450
50righting reflex (GO:0060013)3.66663528
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.66484457
52photoreceptor cell development (GO:0042461)3.65912901
53layer formation in cerebral cortex (GO:0021819)3.60769679
54hyperosmotic salinity response (GO:0042538)3.58211545
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.55767352
56ionotropic glutamate receptor signaling pathway (GO:0035235)3.52774716
57striatum development (GO:0021756)3.50714460
58protein-chromophore linkage (GO:0018298)3.49719521
59GMP metabolic process (GO:0046037)3.48546762
60long-term memory (GO:0007616)3.48030785
61peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.44072620
62potassium ion export (GO:0071435)3.42228758
63eye photoreceptor cell development (GO:0042462)3.42106080
64response to histamine (GO:0034776)3.39178105
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37908836
66positive regulation of membrane potential (GO:0045838)3.35764123
67positive regulation of heart rate (GO:0010460)3.32077821
68negative regulation of leukocyte chemotaxis (GO:0002689)3.28168125
69regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.27817138
70urinary tract smooth muscle contraction (GO:0014848)3.27693617
71vocalization behavior (GO:0071625)3.25618392
72regulation of appetite (GO:0032098)3.22900160
73regulation of neurotransmitter secretion (GO:0046928)3.18148328
74nuclear pore organization (GO:0006999)3.15402674
75retinal cone cell development (GO:0046549)3.14477372
76mating behavior (GO:0007617)3.10535183
77photoreceptor cell maintenance (GO:0045494)3.10319049
78regulation of vesicle fusion (GO:0031338)3.10223011
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09877613
80CENP-A containing nucleosome assembly (GO:0034080)3.09766112
81locomotory exploration behavior (GO:0035641)3.07523292
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07269141
83glycolytic process (GO:0006096)3.06105510
84establishment of synaptic vesicle localization (GO:0097480)3.05278878
85synaptic vesicle transport (GO:0048489)3.05278878
86chromatin remodeling at centromere (GO:0031055)3.05056424
87protein localization to kinetochore (GO:0034501)3.04499039
88regulation of neurotransmitter transport (GO:0051588)3.04306047
89DNA strand renaturation (GO:0000733)3.03483922
90regulation of glutamate receptor signaling pathway (GO:1900449)3.02390855
91regulation of synaptic transmission, glutamatergic (GO:0051966)3.00990301
92detection of light stimulus (GO:0009583)3.00133908
93negative regulation of cation channel activity (GO:2001258)2.99653251
94axon cargo transport (GO:0008088)2.99315687
95fat-soluble vitamin catabolic process (GO:0042363)2.98817080
96vitamin catabolic process (GO:0009111)2.98817080
97cardiac myofibril assembly (GO:0055003)2.97172215
98regulation of postsynaptic membrane potential (GO:0060078)2.92890191
99regulation of axon guidance (GO:1902667)2.91154779
100neuron cell-cell adhesion (GO:0007158)2.89753575
101negative regulation of calcium ion transmembrane transport (GO:1903170)2.87729615
102negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.87729615
103cell communication by electrical coupling (GO:0010644)2.86575509
104regulation of synaptic transmission, GABAergic (GO:0032228)2.86268517
105neurotransmitter secretion (GO:0007269)2.85024277
106detection of visible light (GO:0009584)2.83757284
107regulation of synapse structural plasticity (GO:0051823)2.81713244
108replication fork processing (GO:0031297)2.80557897
109regulation of excitatory postsynaptic membrane potential (GO:0060079)2.79141725
110presynaptic membrane assembly (GO:0097105)2.79132274
111regulation of dopamine secretion (GO:0014059)2.78651890
112negative regulation of circadian rhythm (GO:0042754)2.77957643
113establishment of integrated proviral latency (GO:0075713)2.75529718
114cellular response to light stimulus (GO:0071482)2.75154554
115cellular sodium ion homeostasis (GO:0006883)2.74755231
116mitotic sister chromatid segregation (GO:0000070)2.73575174
117mitotic metaphase plate congression (GO:0007080)2.72148514
118protein K6-linked ubiquitination (GO:0085020)2.71833362
119pyrimidine nucleobase catabolic process (GO:0006208)2.70734651
120neuron fate determination (GO:0048664)2.70521227
121presynaptic membrane organization (GO:0097090)2.68683134
122protein localization to chromosome, centromeric region (GO:0071459)2.68448655
123sister chromatid segregation (GO:0000819)2.62697062
124negative regulation of hormone biosynthetic process (GO:0032353)2.61379925
125hematopoietic stem cell proliferation (GO:0071425)2.59053857
126DNA ligation (GO:0006266)2.56212489
127histone exchange (GO:0043486)2.53450460
128glycerophospholipid catabolic process (GO:0046475)2.52390308
129nucleobase catabolic process (GO:0046113)2.51489982
130mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50716150
131mitochondrial respiratory chain complex I assembly (GO:0032981)2.50716150
132NADH dehydrogenase complex assembly (GO:0010257)2.50716150
133lymphangiogenesis (GO:0001946)2.49881115
134double-strand break repair via nonhomologous end joining (GO:0006303)2.49122771
135non-recombinational repair (GO:0000726)2.49122771
136serine family amino acid biosynthetic process (GO:0009070)2.48299571
137positive regulation of osteoblast proliferation (GO:0033690)2.48202178
138intra-S DNA damage checkpoint (GO:0031573)2.47476352
139protein complex biogenesis (GO:0070271)2.46372905
140metaphase plate congression (GO:0051310)2.44538535
141maturation of 5.8S rRNA (GO:0000460)2.42267313
142cysteine metabolic process (GO:0006534)2.42067137
143mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41870140
144DNA replication checkpoint (GO:0000076)2.40070383
145mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.39937858
146behavioral response to nicotine (GO:0035095)2.39421587
147positive regulation of hair cycle (GO:0042635)2.39038623
148positive regulation of hair follicle development (GO:0051798)2.39038623
149spindle assembly involved in mitosis (GO:0090307)2.38650423
150mitochondrial respiratory chain complex assembly (GO:0033108)2.38042106
151spindle checkpoint (GO:0031577)2.37108649
152maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.35082747
153DNA replication-independent nucleosome assembly (GO:0006336)2.34941104
154DNA replication-independent nucleosome organization (GO:0034724)2.34941104
155DNA replication-dependent nucleosome organization (GO:0034723)2.34275484
156DNA replication-dependent nucleosome assembly (GO:0006335)2.34275484
157aspartate family amino acid catabolic process (GO:0009068)2.33892277
158synapsis (GO:0007129)2.31849713
159retinal ganglion cell axon guidance (GO:0031290)2.31760257
160negative regulation of DNA recombination (GO:0045910)2.30225108
161homocysteine metabolic process (GO:0050667)2.30181273
162negative regulation of DNA-dependent DNA replication (GO:2000104)2.28877950
163mitotic spindle organization (GO:0007052)2.28645450
164protein-cofactor linkage (GO:0018065)2.23367727
165axon ensheathment in central nervous system (GO:0032291)2.22763324
166central nervous system myelination (GO:0022010)2.22763324
167protein K63-linked deubiquitination (GO:0070536)2.22245706
168gonadal mesoderm development (GO:0007506)2.21003771
169DNA strand elongation involved in DNA replication (GO:0006271)2.20380491
170resolution of meiotic recombination intermediates (GO:0000712)2.19334217
171mitotic spindle checkpoint (GO:0071174)2.18649415
172nonmotile primary cilium assembly (GO:0035058)2.17840579
173DNA integration (GO:0015074)2.16560712
174establishment of protein localization to mitochondrial membrane (GO:0090151)2.14782799
175negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.14513668
176mitotic nuclear envelope disassembly (GO:0007077)2.13759245
177kinetochore organization (GO:0051383)2.13148663
178DNA strand elongation (GO:0022616)2.13136306
179negative regulation of hormone metabolic process (GO:0032351)2.12452815
180coenzyme A metabolic process (GO:0015936)2.11915748
181regulation of centriole replication (GO:0046599)2.10064174
182regulation of mitochondrial translation (GO:0070129)2.08825105
183axonal fasciculation (GO:0007413)2.06357391
184sulfation (GO:0051923)2.05766379
185telomere maintenance via semi-conservative replication (GO:0032201)2.04979209
186neuron recognition (GO:0008038)2.04535902
187omega-hydroxylase P450 pathway (GO:0097267)2.04443535
188female gonad development (GO:0008585)2.04225548
189ATP synthesis coupled proton transport (GO:0015986)2.03986980
190energy coupled proton transport, down electrochemical gradient (GO:0015985)2.03986980
191kinetochore assembly (GO:0051382)2.02867947
192sex differentiation (GO:0007548)2.02728131
193protein sumoylation (GO:0016925)2.02496395
194cerebral cortex radially oriented cell migration (GO:0021799)2.02224128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.67123199
2GBX2_23144817_ChIP-Seq_PC3_Human4.45656958
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.36990348
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.96123964
5E2F7_22180533_ChIP-Seq_HELA_Human3.79083361
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.37894656
7VDR_22108803_ChIP-Seq_LS180_Human3.30645955
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.08291003
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.94429459
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93604483
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89851729
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.89194638
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80471657
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79150590
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77078312
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65549982
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64432723
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61565133
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60971917
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60971917
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60499308
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.49044145
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47404830
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.45551507
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33984790
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31152494
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30403136
28REST_21632747_ChIP-Seq_MESCs_Mouse2.25319132
29EZH2_27304074_Chip-Seq_ESCs_Mouse2.18431988
30CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17711885
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11943991
32RARB_27405468_Chip-Seq_BRAIN_Mouse2.11194215
33DROSHA_22980978_ChIP-Seq_HELA_Human2.10105345
34EST1_17652178_ChIP-ChIP_JURKAT_Human2.09882581
35CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06810697
36SALL1_21062744_ChIP-ChIP_HESCs_Human2.06547508
37REST_18959480_ChIP-ChIP_MESCs_Mouse2.04593089
38GABP_17652178_ChIP-ChIP_JURKAT_Human2.00447068
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98738626
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98544338
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96052271
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94857968
43TAF15_26573619_Chip-Seq_HEK293_Human1.94397789
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94267455
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94172199
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.92760858
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91895146
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79385311
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76466192
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.72595018
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70842317
52P53_22127205_ChIP-Seq_FIBROBLAST_Human1.65210801
53ZNF274_21170338_ChIP-Seq_K562_Hela1.61280487
54SMAD4_21799915_ChIP-Seq_A2780_Human1.59972831
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59373618
56P300_19829295_ChIP-Seq_ESCs_Human1.58788175
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58697568
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58046541
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56940002
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.54560070
61TTF2_22483619_ChIP-Seq_HELA_Human1.54442659
62ELK1_19687146_ChIP-ChIP_HELA_Human1.50039587
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.47555661
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46558085
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44859650
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42492682
67MYC_18940864_ChIP-ChIP_HL60_Human1.42351201
68AR_21909140_ChIP-Seq_LNCAP_Human1.41720451
69DCP1A_22483619_ChIP-Seq_HELA_Human1.40179696
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37582640
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35117199
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35065500
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34392882
74* ETS1_20019798_ChIP-Seq_JURKAT_Human1.33723514
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33664743
76AR_25329375_ChIP-Seq_VCAP_Human1.33549131
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32112293
78FUS_26573619_Chip-Seq_HEK293_Human1.31807097
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29818334
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29457996
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28505916
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.27856733
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27107930
84BCAT_22108803_ChIP-Seq_LS180_Human1.26225833
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.25385750
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.24883865
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.24673673
88RNF2_27304074_Chip-Seq_NSC_Mouse1.23689082
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21305628
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20901089
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20397083
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.20298162
93* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20124698
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.18625583
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.18489587
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17781380
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17137941
98CTCF_27219007_Chip-Seq_Bcells_Human1.16651608
99AR_19668381_ChIP-Seq_PC3_Human1.16348690
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.16270065
101* STAT3_23295773_ChIP-Seq_U87_Human1.16072156
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15336865
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14258402
104AR_21572438_ChIP-Seq_LNCaP_Human1.13729899
105XRN2_22483619_ChIP-Seq_HELA_Human1.12397774
106TBL1_22424771_ChIP-Seq_293T_Human1.11684541
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.09573468
108SMAD3_21741376_ChIP-Seq_HESCs_Human1.09398049
109TCF4_23295773_ChIP-Seq_U87_Human1.09121078
110LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08190688
111NANOG_16153702_ChIP-ChIP_HESCs_Human1.08114339
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07907079
113FOXP3_21729870_ChIP-Seq_TREG_Human1.07637793
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06220558
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06079169
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.05598015
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05249451
118SOX9_26525672_Chip-Seq_HEART_Mouse1.04835166
119IGF1R_20145208_ChIP-Seq_DFB_Human1.04785903
120TRIM28_21343339_ChIP-Seq_HEK293_Human1.04064549
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03847419
122VDR_23849224_ChIP-Seq_CD4+_Human1.03269571
123ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03225709
124MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02943246
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02204907
126EWS_26573619_Chip-Seq_HEK293_Human1.01804038
127TP63_19390658_ChIP-ChIP_HaCaT_Human1.01086889
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00730102
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99530043
130CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98918749
131JUN_21703547_ChIP-Seq_K562_Human0.98681578
132FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98399920
133YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97313143
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97312957
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96025714
136TCF4_22108803_ChIP-Seq_LS180_Human0.95903929
137RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94587170
138SOX3_22085726_ChIP-Seq_NPCs_Mouse0.93827337
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93012861
140SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91822391
141EZH2_27294783_Chip-Seq_NPCs_Mouse0.91737694
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91582360
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90554341
144WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90480426
145MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89784720
146CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89773577
147CBP_20019798_ChIP-Seq_JUKART_Human0.89282970
148IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89282970
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.89233294
150EP300_21415370_ChIP-Seq_HL-1_Mouse0.89094072
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.88273990
152SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.87934663
153CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87868249
154MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87776913
155SRF_21415370_ChIP-Seq_HL-1_Mouse0.87515077
156MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87339148
157PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87089531
158PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86958239
159SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86412943
160RING1B_27294783_Chip-Seq_NPCs_Mouse0.86357610
161PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86180948
162POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85817898
163TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85817898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog5.41729469
2MP0004859_abnormal_synaptic_plasticity4.05098044
3MP0001984_abnormal_olfaction3.73524895
4MP0003880_abnormal_central_pattern3.30669984
5MP0003787_abnormal_imprinting3.07231701
6MP0002090_abnormal_vision3.03649823
7MP0003635_abnormal_synaptic_transmissio2.85694460
8MP0002735_abnormal_chemical_nociception2.80967154
9MP0002822_catalepsy2.78516740
10MP0006292_abnormal_olfactory_placode2.76293898
11MP0003136_yellow_coat_color2.54939040
12MP0006072_abnormal_retinal_apoptosis2.46013992
13MP0000372_irregular_coat_pigmentation2.41272422
14MP0005253_abnormal_eye_physiology2.38683460
15MP0003011_delayed_dark_adaptation2.37008174
16MP0001968_abnormal_touch/_nociception2.34805418
17MP0000566_synostosis2.33043373
18MP0002063_abnormal_learning/memory/cond2.26979549
19MP0002272_abnormal_nervous_system2.23651551
20MP0009046_muscle_twitch2.22681517
21MP0002938_white_spotting2.19824915
22MP0009745_abnormal_behavioral_response2.18177108
23MP0002736_abnormal_nociception_after2.17703437
24MP0002064_seizures2.14891405
25MP0002638_abnormal_pupillary_reflex2.11981356
26MP0006276_abnormal_autonomic_nervous2.10156000
27MP0005195_abnormal_posterior_eye2.08057188
28MP0001486_abnormal_startle_reflex2.07640637
29MP0001502_abnormal_circadian_rhythm2.05826564
30MP0010386_abnormal_urinary_bladder2.01774831
31MP0002734_abnormal_mechanical_nocicepti1.98867698
32MP0010094_abnormal_chromosome_stability1.98096399
33MP0005423_abnormal_somatic_nervous1.96992904
34MP0001346_abnormal_lacrimal_gland1.91235950
35MP0004036_abnormal_muscle_relaxation1.90642091
36MP0002572_abnormal_emotion/affect_behav1.84596602
37MP0004084_abnormal_cardiac_muscle1.83308793
38MP0003693_abnormal_embryo_hatching1.81645665
39MP0002067_abnormal_sensory_capabilities1.80130112
40MP0008877_abnormal_DNA_methylation1.79915878
41MP0004270_analgesia1.72342222
42MP0008058_abnormal_DNA_repair1.72053193
43MP0003121_genomic_imprinting1.69898910
44MP0000749_muscle_degeneration1.68038620
45MP0004215_abnormal_myocardial_fiber1.66659580
46MP0010368_abnormal_lymphatic_system1.65883025
47MP0002229_neurodegeneration1.64447584
48MP0005171_absent_coat_pigmentation1.58669582
49MP0001440_abnormal_grooming_behavior1.57733605
50MP0001188_hyperpigmentation1.56971185
51MP0010030_abnormal_orbit_morphology1.56123916
52MP0001293_anophthalmia1.55323025
53MP0003950_abnormal_plasma_membrane1.51315080
54MP0002184_abnormal_innervation1.49657106
55MP0003122_maternal_imprinting1.49468367
56MP0005394_taste/olfaction_phenotype1.46879180
57MP0005499_abnormal_olfactory_system1.46879180
58MP0001501_abnormal_sleep_pattern1.46462486
59MP0002882_abnormal_neuron_morphology1.46283591
60MP0000631_abnormal_neuroendocrine_gland1.45564091
61MP0004142_abnormal_muscle_tone1.45402191
62MP0003937_abnormal_limbs/digits/tail_de1.42278081
63MP0008569_lethality_at_weaning1.39706243
64MP0004957_abnormal_blastocyst_morpholog1.38754292
65MP0004858_abnormal_nervous_system1.37184704
66MP0003111_abnormal_nucleus_morphology1.34772572
67MP0003718_maternal_effect1.32482062
68MP0008057_abnormal_DNA_replication1.28875004
69MP0001970_abnormal_pain_threshold1.27349580
70MP0005084_abnormal_gallbladder_morpholo1.27073511
71MP0002752_abnormal_somatic_nervous1.26212446
72MP0008789_abnormal_olfactory_epithelium1.25570518
73MP0003172_abnormal_lysosome_physiology1.25547821
74MP0003119_abnormal_digestive_system1.24129750
75MP0002233_abnormal_nose_morphology1.23672318
76MP0002909_abnormal_adrenal_gland1.22515966
77MP0008932_abnormal_embryonic_tissue1.21405643
78MP0003077_abnormal_cell_cycle1.20157903
79MP0003861_abnormal_nervous_system1.18454557
80MP0004233_abnormal_muscle_weight1.18118105
81MP0008004_abnormal_stomach_pH1.17289685
82MP0003879_abnormal_hair_cell1.16854768
83MP0002837_dystrophic_cardiac_calcinosis1.15534372
84MP0004085_abnormal_heartbeat1.14707963
85MP0000569_abnormal_digit_pigmentation1.14307641
86MP0005409_darkened_coat_color1.13589046
87MP0001529_abnormal_vocalization1.12474555
88MP0002163_abnormal_gland_morphology1.09195551
89MP0002557_abnormal_social/conspecific_i1.08358120
90MP0002234_abnormal_pharynx_morphology1.08227781
91MP0000049_abnormal_middle_ear1.08113814
92MP0003938_abnormal_ear_development1.07643388
93MP0001324_abnormal_eye_pigmentation1.07340902
94MP0005620_abnormal_muscle_contractility1.07085857
95MP0003315_abnormal_perineum_morphology1.05141269
96MP0002697_abnormal_eye_size1.03943161
97MP0004811_abnormal_neuron_physiology1.03589434
98MP0004510_myositis1.03059659
99MP0001299_abnormal_eye_distance/1.01983882
100MP0008961_abnormal_basal_metabolism0.99912863
101MP0005391_vision/eye_phenotype0.96880687
102MP0001905_abnormal_dopamine_level0.96721721
103MP0005623_abnormal_meninges_morphology0.95870830
104MP0000534_abnormal_ureter_morphology0.94357483
105MP0002066_abnormal_motor_capabilities/c0.92010541
106MP0005595_abnormal_vascular_smooth0.90499201
107MP0001286_abnormal_eye_development0.90429514
108MP0000955_abnormal_spinal_cord0.89050398
109MP0003755_abnormal_palate_morphology0.88810831
110MP0000778_abnormal_nervous_system0.88666445
111MP0005386_behavior/neurological_phenoty0.88039049
112MP0004924_abnormal_behavior0.88039049
113MP0004133_heterotaxia0.87527334
114MP0009250_abnormal_appendicular_skeleto0.86362878
115MP0005451_abnormal_body_composition0.85579984
116MP0002084_abnormal_developmental_patter0.85231837
117MP0005187_abnormal_penis_morphology0.84631038
118MP0003567_abnormal_fetal_cardiomyocyte0.84511856
119MP0003868_abnormal_feces_composition0.81643348
120MP0004145_abnormal_muscle_electrophysio0.81072677
121MP0002972_abnormal_cardiac_muscle0.80971996
122MP0002085_abnormal_embryonic_tissue0.80659506
123MP0003385_abnormal_body_wall0.80105963
124MP0004484_altered_response_of0.79601189
125MP0002928_abnormal_bile_duct0.79084788
126MP0002733_abnormal_thermal_nociception0.78298706
127MP0002210_abnormal_sex_determination0.77112718
128MP0000537_abnormal_urethra_morphology0.77016893
129MP0000751_myopathy0.76959296
130MP0002160_abnormal_reproductive_system0.76623599
131MP0001485_abnormal_pinna_reflex0.75274100
132MP0001177_atelectasis0.74968900
133MP0002177_abnormal_outer_ear0.74957042
134MP0009697_abnormal_copulation0.74184572
135MP0000647_abnormal_sebaceous_gland0.73962410
136MP0003935_abnormal_craniofacial_develop0.73587927
137MP0002152_abnormal_brain_morphology0.73457906
138MP0000613_abnormal_salivary_gland0.72359608
139MP0003183_abnormal_peptide_metabolism0.72096226
140MP0002127_abnormal_cardiovascular_syste0.71221201
141MP0003890_abnormal_embryonic-extraembry0.68239772
142MP0002102_abnormal_ear_morphology0.67526324
143MP0002269_muscular_atrophy0.64681301
144MP0005330_cardiomyopathy0.63872638
145MP0003633_abnormal_nervous_system0.61864619
146MP0004742_abnormal_vestibular_system0.61707836
147MP0008775_abnormal_heart_ventricle0.60346849
148MP0004043_abnormal_pH_regulation0.59683248

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)6.91624331
2Increased corneal curvature (HP:0100692)6.11698239
3Keratoconus (HP:0000563)6.11698239
4Abnormal rod and cone electroretinograms (HP:0008323)5.80063802
5Abnormality of macular pigmentation (HP:0008002)5.72887298
6Severe visual impairment (HP:0001141)5.20541523
7Abnormal gallbladder physiology (HP:0012438)5.13002778
8Cholecystitis (HP:0001082)5.13002778
9Scotoma (HP:0000575)4.92041461
10Epileptic encephalopathy (HP:0200134)4.81959680
11Decreased central vision (HP:0007663)4.63668882
12Myokymia (HP:0002411)4.31871804
13Focal motor seizures (HP:0011153)4.30511470
14Bony spicule pigmentary retinopathy (HP:0007737)4.12078685
15Absent rod-and cone-mediated responses on ERG (HP:0007688)4.11380971
16Absence seizures (HP:0002121)3.98313618
17Febrile seizures (HP:0002373)3.64363612
18Dialeptic seizures (HP:0011146)3.49853692
19Atonic seizures (HP:0010819)3.25924098
20Abnormal pupillary function (HP:0007686)3.16972643
21Abnormality of the labia minora (HP:0012880)3.16967852
22Progressive cerebellar ataxia (HP:0002073)3.14202456
23Focal seizures (HP:0007359)3.10818582
24Cortical dysplasia (HP:0002539)3.08716870
25Generalized tonic-clonic seizures (HP:0002069)2.92836184
26Partial agenesis of the corpus callosum (HP:0001338)2.88729873
27Chorioretinal atrophy (HP:0000533)2.77385421
28Aplasia/Hypoplasia of the fovea (HP:0008060)2.76916467
29Hypoplasia of the fovea (HP:0007750)2.76916467
30True hermaphroditism (HP:0010459)2.75337735
31Dyschromatopsia (HP:0007641)2.70281970
32Exercise-induced muscle cramps (HP:0003710)2.69642768
33Abolished electroretinogram (ERG) (HP:0000550)2.68204997
34Septo-optic dysplasia (HP:0100842)2.67570163
35Exercise-induced myalgia (HP:0003738)2.66917457
36EEG with generalized epileptiform discharges (HP:0011198)2.66524621
37Decreased circulating renin level (HP:0003351)2.66229988
38Pancreatic fibrosis (HP:0100732)2.64605404
39Epileptiform EEG discharges (HP:0011182)2.62512592
40Molar tooth sign on MRI (HP:0002419)2.61644944
41Abnormality of midbrain morphology (HP:0002418)2.61644944
42Visual hallucinations (HP:0002367)2.58229517
43Pigmentary retinal degeneration (HP:0001146)2.56111229
44Acute encephalopathy (HP:0006846)2.54877801
45Pendular nystagmus (HP:0012043)2.54011068
46Pancreatic cysts (HP:0001737)2.49177128
47Photophobia (HP:0000613)2.47214726
48Bifid tongue (HP:0010297)2.45392213
49Choroideremia (HP:0001139)2.43780028
50Abnormal pancreas size (HP:0012094)2.43240466
51Hepatocellular necrosis (HP:0001404)2.39411367
52Hyperglycinemia (HP:0002154)2.39180648
53Nephronophthisis (HP:0000090)2.35680106
54Acute necrotizing encephalopathy (HP:0006965)2.35168385
55Abnormal lung lobation (HP:0002101)2.33227652
56Abnormality of the fovea (HP:0000493)2.29446288
57Widely spaced teeth (HP:0000687)2.28676403
58Preaxial foot polydactyly (HP:0001841)2.27590641
59Attenuation of retinal blood vessels (HP:0007843)2.26661095
60Intestinal atresia (HP:0011100)2.24627954
61Optic disc pallor (HP:0000543)2.22637634
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.18872624
63Abnormality of the ileum (HP:0001549)2.18518932
64Atrial fibrillation (HP:0005110)2.16830505
65Meckel diverticulum (HP:0002245)2.16732232
66Type II diabetes mellitus (HP:0005978)2.16372519
67Chorioretinal coloboma (HP:0000567)2.16250508
68Absent radius (HP:0003974)2.15287846
69Aplasia/Hypoplasia of the macula (HP:0008059)2.14899729
70Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12098822
71Supraventricular tachycardia (HP:0004755)2.11985127
72Aplasia/Hypoplasia of the tongue (HP:0010295)2.11844069
73Retinal dysplasia (HP:0007973)2.11213413
74Absent forearm bone (HP:0003953)2.09889594
75Aplasia involving forearm bones (HP:0009822)2.09889594
76Incomplete penetrance (HP:0003829)2.09827651
77Horseshoe kidney (HP:0000085)2.09624639
78Bicornuate uterus (HP:0000813)2.08377271
79Abnormality of alanine metabolism (HP:0010916)2.08075589
80Hyperalaninemia (HP:0003348)2.08075589
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08075589
82Primary atrial arrhythmia (HP:0001692)2.07412992
83Abnormal mitochondria in muscle tissue (HP:0008316)2.07059529
84Hepatoblastoma (HP:0002884)2.06551054
85Triphalangeal thumb (HP:0001199)2.06495005
86Hepatic necrosis (HP:0002605)2.06398315
87Congenital sensorineural hearing impairment (HP:0008527)2.05983243
88Syncope (HP:0001279)2.05160675
89Mitochondrial inheritance (HP:0001427)2.03815769
90Macular degeneration (HP:0000608)2.03667451
91Abnormality of chromosome stability (HP:0003220)2.03574187
92Supraventricular arrhythmia (HP:0005115)2.03150643
93Optic nerve hypoplasia (HP:0000609)2.02919148
94Oligodactyly (hands) (HP:0001180)2.02305392
95Dysdiadochokinesis (HP:0002075)2.01948214
96Constricted visual fields (HP:0001133)2.01594171
97Progressive macrocephaly (HP:0004481)2.01576696
98Aplasia/hypoplasia of the uterus (HP:0008684)2.00283018
99Congenital stationary night blindness (HP:0007642)10.0536188
100Sudden death (HP:0001699)1.99950104
101Truncal ataxia (HP:0002078)1.98686089
102Gastrointestinal atresia (HP:0002589)1.98559513
103Anxiety (HP:0000739)1.97731234
104Chromsome breakage (HP:0040012)1.95205237
105Retinitis pigmentosa (HP:0000510)1.94624503
106Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94028908
107Esophageal atresia (HP:0002032)1.93942846
108Prolonged QT interval (HP:0001657)1.92045063
109Myelomeningocele (HP:0002475)1.91494073
110Abnormality of abdominal situs (HP:0011620)1.91298049
111Abdominal situs inversus (HP:0003363)1.91298049
112Abnormal hair whorl (HP:0010721)1.90034114
113Cerebellar dysplasia (HP:0007033)1.89997769
114Ectopic kidney (HP:0000086)1.88092478
115Reticulocytopenia (HP:0001896)1.86688729
116Hyperinsulinemic hypoglycemia (HP:0000825)1.84355416
117Cone-rod dystrophy (HP:0000548)1.83266431
118Hemiparesis (HP:0001269)1.83256452
119Bile duct proliferation (HP:0001408)1.83150761
120Abnormal biliary tract physiology (HP:0012439)1.83150761
121Increased hepatocellular lipid droplets (HP:0006565)1.82751188
122Lower limb hyperreflexia (HP:0002395)1.82713290
123Posterior subcapsular cataract (HP:0007787)1.82175638
124Aplasia/Hypoplasia affecting the retina (HP:0008061)1.82086171
125Anencephaly (HP:0002323)1.81796297
126Stenosis of the external auditory canal (HP:0000402)1.81773796
127Gout (HP:0001997)1.81560931
128Depression (HP:0000716)1.81525500
129Hypoplasia of the uterus (HP:0000013)1.81286299
130Duplication of thumb phalanx (HP:0009942)1.80548338
131Medial flaring of the eyebrow (HP:0010747)1.80315785
132Hypsarrhythmia (HP:0002521)1.80129882
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.79220961
134Chronic hepatic failure (HP:0100626)1.79129683
135Excessive salivation (HP:0003781)1.77570530
136Drooling (HP:0002307)1.77570530
137Ependymoma (HP:0002888)1.77060477
138Increased CSF lactate (HP:0002490)1.76669629
139Oligodactyly (HP:0012165)1.76158756
140Preaxial hand polydactyly (HP:0001177)1.74452446
141Type 2 muscle fiber atrophy (HP:0003554)1.74417936
142Intellectual disability, moderate (HP:0002342)1.74328790
143Methylmalonic acidemia (HP:0002912)1.74145023
144Congenital primary aphakia (HP:0007707)1.73992708
145Poor suck (HP:0002033)1.73138294
146Gait imbalance (HP:0002141)1.72953059
147Supernumerary spleens (HP:0009799)1.71405660
148Anophthalmia (HP:0000528)1.71193387
149Nephrogenic diabetes insipidus (HP:0009806)1.70989108
150Unsteady gait (HP:0002317)1.70359111
151Sloping forehead (HP:0000340)1.70054823
152Limb dystonia (HP:0002451)1.68966195
153Albinism (HP:0001022)1.68933659
154Multiple enchondromatosis (HP:0005701)1.68830774
155Dysmetria (HP:0001310)1.68707156
156Amblyopia (HP:0000646)1.66115274
157Gaze-evoked nystagmus (HP:0000640)1.65418373
158Genital tract atresia (HP:0001827)1.65088583
1593-Methylglutaconic aciduria (HP:0003535)1.65019265
160Ventricular arrhythmia (HP:0004308)1.64847214
161Abnormality of the renal medulla (HP:0100957)1.64758023
162Cystic liver disease (HP:0006706)1.64184749
163Abnormality of the duodenum (HP:0002246)1.64076025
164Leukodystrophy (HP:0002415)1.63372320
165Calf muscle hypertrophy (HP:0008981)1.62892530
166Left ventricular hypertrophy (HP:0001712)1.62726974
167Torticollis (HP:0000473)1.62357574
168Labial hypoplasia (HP:0000066)1.62337545
169Horizontal nystagmus (HP:0000666)1.61646404
170Duodenal stenosis (HP:0100867)1.61536204
171Small intestinal stenosis (HP:0012848)1.61536204
172Skin nodule (HP:0200036)1.61450193
173Renal hypoplasia (HP:0000089)1.61268789
174Small epiphyses (HP:0010585)1.60944035
175Cerebral edema (HP:0002181)1.60739778
176Action tremor (HP:0002345)1.60270437
177Increased circulating renin level (HP:0000848)1.60178466
178Vaginal atresia (HP:0000148)1.60163434
179Bilateral microphthalmos (HP:0007633)1.59815330
180Ventricular fibrillation (HP:0001663)1.59350641
181Spondylolisthesis (HP:0003302)1.58958669
182Prominent nasal bridge (HP:0000426)1.58430629
183Astigmatism (HP:0000483)1.58226788
184Paraplegia (HP:0010550)1.58183589
185Fetal akinesia sequence (HP:0001989)1.57717776
186Hypoplastic female external genitalia (HP:0012815)1.57562449
187Specific learning disability (HP:0001328)1.56422287
188Hemivertebrae (HP:0002937)1.55266924
189Lipid accumulation in hepatocytes (HP:0006561)1.54582059
190Unilateral renal agenesis (HP:0000122)1.54350953
191Impaired vibration sensation in the lower limbs (HP:0002166)1.54331884
192Poikiloderma (HP:0001029)1.53618608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK7.59186749
2NME14.38773052
3WNK33.90466281
4PRPF4B3.55421865
5STK38L3.36588102
6FRK2.82736578
7MAP3K92.62522775
8MARK12.59650003
9BUB12.57398021
10NEK12.55764646
11OBSCN2.49886159
12PAK62.40775577
13TRIM282.30107587
14CDC72.27912088
15TTK2.25601740
16BCR2.18343991
17MINK12.17219545
18NTRK32.13036167
19CDK32.04477121
20RIPK12.02673559
21KSR22.02517678
22TAOK22.01586692
23STK381.95506451
24PLK31.93381633
25EIF2AK31.87858267
26WEE11.86411227
27EPHA41.82760276
28SRPK11.71392460
29PLK41.67559569
30CCNB11.66303064
31FES1.58800705
32MKNK11.54508699
33KSR11.47767204
34ARAF1.43834261
35FGFR21.42127536
36BRSK21.41989292
37PHKG21.39978382
38PHKG11.39978382
39DYRK21.39064007
40MYLK1.37259772
41MAP3K131.35062576
42TSSK61.34684167
43MKNK21.34077921
44DYRK1A1.33387348
45STK161.28615209
46CLK11.27082335
47PRKD31.24406644
48CDK191.23807938
49TNIK1.21417938
50EIF2AK11.21292183
51CAMK2D1.18691980
52VRK11.17783728
53PLK11.15014610
54ERBB31.12219729
55TLK11.10693619
56PKN21.10325903
57NEK21.10209600
58CDK141.09732572
59TAF11.01272695
60BMPR1B0.98471689
61PTK2B0.96717883
62GRK10.96263566
63MAP2K70.93998816
64YES10.92903814
65PASK0.92317361
66CAMK2A0.91246385
67CDK180.89511509
68CDK150.89085219
69CAMK10.88771895
70EPHB20.88036958
71PLK20.86899964
72MAP4K20.86627818
73VRK20.85845522
74ZAK0.85300404
75TXK0.84044068
76NTRK10.83946462
77CDK50.83024873
78STK240.83001263
79BMPR20.82524222
80PAK30.82037314
81MAP3K70.79944788
82SGK2230.79921762
83SGK4940.79921762
84CSNK1G10.78807434
85STK30.78270369
86ATR0.74619343
87CDK11A0.74584743
88MAP2K40.74263463
89PINK10.72596719
90DYRK30.71045641
91AURKB0.70639422
92CDC42BPA0.70066952
93RAF10.69637338
94CSNK1G30.68612741
95CSNK1G20.68469411
96BRAF0.66961908
97GRK50.66936587
98DAPK20.66899380
99PRKCG0.66318033
100PRKAA10.64515718
101EIF2AK20.64057541
102WNK40.63368709
103AURKA0.63329661
104MARK20.62928393
105MAPK130.62113780
106SIK30.61479519
107SIK20.60985606
108BRD40.60301241
109MAPK70.59579474
110PKN10.58774972
111MAP3K40.58656101
112LIMK10.58487703
113NTRK20.57539233
114FER0.56817616
115FGFR10.56543395
116CSNK1E0.55809414
117ATM0.53766301
118BRSK10.53626889
119ADRBK20.52253272
120CDK10.51433536
121PRKDC0.51133329
122PIK3CA0.51072489
123PRKCA0.50040591
124IRAK10.48815681
125DYRK1B0.48798442
126RPS6KA40.48730388
127CSNK1A1L0.47348318
128CHEK10.46995045
129CSNK1A10.46061896
130CASK0.45437074
131LATS20.44487404
132CAMK1G0.44103266
133MOS0.43715435
134PRKG10.43308194
135MARK30.42425100
136PRKCB0.40883100
137PRKCZ0.39042033
138PNCK0.36586033
139CSNK2A20.36534355
140PRKD20.36222327
141PRKCE0.35054904
142EGFR0.33857339
143PRKG20.32977084
144CAMK2G0.32938886
145PRKACA0.32661018
146DAPK30.32311765
147MAPK100.31817877
148SGK10.30560719
149MAP2K10.30312229
150MAP3K20.30269573
151LMTK20.29853121
152PRKACB0.29039372
153RPS6KA30.28778357
154GRK70.27777403
155CHEK20.27384649
156UHMK10.25847138
157RIPK40.24635716
158ERBB20.24096131

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.73328205
2Phototransduction_Homo sapiens_hsa047443.80750767
3Synaptic vesicle cycle_Homo sapiens_hsa047213.80622719
4GABAergic synapse_Homo sapiens_hsa047273.51401779
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.46931057
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.33997690
7Morphine addiction_Homo sapiens_hsa050323.27352712
8Circadian entrainment_Homo sapiens_hsa047132.99961097
9Olfactory transduction_Homo sapiens_hsa047402.86700845
10Cardiac muscle contraction_Homo sapiens_hsa042602.74985440
11Propanoate metabolism_Homo sapiens_hsa006402.34458243
12Glutamatergic synapse_Homo sapiens_hsa047242.29645747
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.22421292
14Taste transduction_Homo sapiens_hsa047422.22356898
15DNA replication_Homo sapiens_hsa030302.18426645
16Non-homologous end-joining_Homo sapiens_hsa034502.18376884
17Cholinergic synapse_Homo sapiens_hsa047252.14561686
18Mismatch repair_Homo sapiens_hsa034302.13142184
19Butanoate metabolism_Homo sapiens_hsa006502.12815751
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.08201046
21Protein export_Homo sapiens_hsa030601.98140842
22Selenocompound metabolism_Homo sapiens_hsa004501.93457794
23Steroid biosynthesis_Homo sapiens_hsa001001.91766980
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.88920408
25Insulin secretion_Homo sapiens_hsa049111.88801193
26Dilated cardiomyopathy_Homo sapiens_hsa054141.84093330
27Dopaminergic synapse_Homo sapiens_hsa047281.80269380
28Serotonergic synapse_Homo sapiens_hsa047261.79896789
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.77761775
30Renin secretion_Homo sapiens_hsa049241.77636586
31Homologous recombination_Homo sapiens_hsa034401.77131215
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75916313
33RNA polymerase_Homo sapiens_hsa030201.72414776
34Long-term potentiation_Homo sapiens_hsa047201.65432304
35Proteasome_Homo sapiens_hsa030501.65399860
36Oxytocin signaling pathway_Homo sapiens_hsa049211.64253429
37RNA transport_Homo sapiens_hsa030131.60566150
38Circadian rhythm_Homo sapiens_hsa047101.60537079
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.59813381
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57154243
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56760712
42Salivary secretion_Homo sapiens_hsa049701.54484194
43Fanconi anemia pathway_Homo sapiens_hsa034601.52608408
44Fructose and mannose metabolism_Homo sapiens_hsa000511.49716729
45Calcium signaling pathway_Homo sapiens_hsa040201.41917807
46Ribosome_Homo sapiens_hsa030101.41766235
47Cell cycle_Homo sapiens_hsa041101.40774831
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37736593
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37171599
50Nucleotide excision repair_Homo sapiens_hsa034201.35452735
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.35325127
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32830550
53Collecting duct acid secretion_Homo sapiens_hsa049661.27875586
54Base excision repair_Homo sapiens_hsa034101.26042998
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25445172
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24736800
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23078034
58Spliceosome_Homo sapiens_hsa030401.22538562
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17279184
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17258491
61Central carbon metabolism in cancer_Homo sapiens_hsa052301.14754747
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14706586
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14704255
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.14124699
65Basal transcription factors_Homo sapiens_hsa030221.12790636
66Amphetamine addiction_Homo sapiens_hsa050311.08889772
67Biosynthesis of amino acids_Homo sapiens_hsa012301.06911243
68RNA degradation_Homo sapiens_hsa030181.04600295
69Long-term depression_Homo sapiens_hsa047301.02238811
70Folate biosynthesis_Homo sapiens_hsa007901.01128652
71Type II diabetes mellitus_Homo sapiens_hsa049300.99643701
72Basal cell carcinoma_Homo sapiens_hsa052170.99266976
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.99133563
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99126918
75Hedgehog signaling pathway_Homo sapiens_hsa043400.97835050
76Oxidative phosphorylation_Homo sapiens_hsa001900.97033549
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92241948
78Pyrimidine metabolism_Homo sapiens_hsa002400.91483136
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88745676
80Parkinsons disease_Homo sapiens_hsa050120.87567014
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86925973
82Alzheimers disease_Homo sapiens_hsa050100.86841615
83GnRH signaling pathway_Homo sapiens_hsa049120.86243154
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85496208
85cAMP signaling pathway_Homo sapiens_hsa040240.83677523
86Fatty acid metabolism_Homo sapiens_hsa012120.81262359
87Arginine and proline metabolism_Homo sapiens_hsa003300.80992113
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79794483
89Gap junction_Homo sapiens_hsa045400.79356313
90Peroxisome_Homo sapiens_hsa041460.78239974
91Hippo signaling pathway_Homo sapiens_hsa043900.76453187
92mRNA surveillance pathway_Homo sapiens_hsa030150.75528675
93Axon guidance_Homo sapiens_hsa043600.74328693
94Arginine biosynthesis_Homo sapiens_hsa002200.73957916
95Cocaine addiction_Homo sapiens_hsa050300.72809421
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72441888
97Lysine degradation_Homo sapiens_hsa003100.69192735
98Inositol phosphate metabolism_Homo sapiens_hsa005620.68336306
99Metabolic pathways_Homo sapiens_hsa011000.68081005
100Glutathione metabolism_Homo sapiens_hsa004800.66806164
101mTOR signaling pathway_Homo sapiens_hsa041500.64711509
102Gastric acid secretion_Homo sapiens_hsa049710.63024428
103Huntingtons disease_Homo sapiens_hsa050160.62597315
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61857703
105Ether lipid metabolism_Homo sapiens_hsa005650.61680497
106N-Glycan biosynthesis_Homo sapiens_hsa005100.60609383
107Carbon metabolism_Homo sapiens_hsa012000.60446380
108Estrogen signaling pathway_Homo sapiens_hsa049150.60254664
109Alcoholism_Homo sapiens_hsa050340.59727250
110One carbon pool by folate_Homo sapiens_hsa006700.59592854
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58030355
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57402314
113Fatty acid degradation_Homo sapiens_hsa000710.57306366
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57106936
115beta-Alanine metabolism_Homo sapiens_hsa004100.56527718
116p53 signaling pathway_Homo sapiens_hsa041150.54939379
117Vibrio cholerae infection_Homo sapiens_hsa051100.54624554
118Glioma_Homo sapiens_hsa052140.54013177
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53610039
120Tryptophan metabolism_Homo sapiens_hsa003800.51723892
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51121161
122Galactose metabolism_Homo sapiens_hsa000520.50914347
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48072260
124Glucagon signaling pathway_Homo sapiens_hsa049220.46432063
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43805253
126Melanogenesis_Homo sapiens_hsa049160.43548327
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43265669
128Fatty acid elongation_Homo sapiens_hsa000620.43011147
129Pancreatic secretion_Homo sapiens_hsa049720.42298200
130Nitrogen metabolism_Homo sapiens_hsa009100.42171210
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.41858200
132HIF-1 signaling pathway_Homo sapiens_hsa040660.41523274
133TGF-beta signaling pathway_Homo sapiens_hsa043500.41359134
134Linoleic acid metabolism_Homo sapiens_hsa005910.41089406
135ErbB signaling pathway_Homo sapiens_hsa040120.38968224
136Endometrial cancer_Homo sapiens_hsa052130.38323500
137Fat digestion and absorption_Homo sapiens_hsa049750.37977161
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37639842
139Pentose phosphate pathway_Homo sapiens_hsa000300.37523851
140Purine metabolism_Homo sapiens_hsa002300.37118661
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.36163446
142Choline metabolism in cancer_Homo sapiens_hsa052310.34886684
143Oocyte meiosis_Homo sapiens_hsa041140.34884901
144Renal cell carcinoma_Homo sapiens_hsa052110.33996750
145VEGF signaling pathway_Homo sapiens_hsa043700.33397457
146Pyruvate metabolism_Homo sapiens_hsa006200.31777459
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30810327
148Prion diseases_Homo sapiens_hsa050200.29471197
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28965504
150Melanoma_Homo sapiens_hsa052180.28507964
151MAPK signaling pathway_Homo sapiens_hsa040100.27747100
152Colorectal cancer_Homo sapiens_hsa052100.27682990
1532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27582175
154Ras signaling pathway_Homo sapiens_hsa040140.26342259
155Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23298623
156Thyroid hormone synthesis_Homo sapiens_hsa049180.22995973
157Bile secretion_Homo sapiens_hsa049760.21397814
158Tight junction_Homo sapiens_hsa045300.21038409
159Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20277241
160Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17098088
161Wnt signaling pathway_Homo sapiens_hsa043100.16201612
162Non-small cell lung cancer_Homo sapiens_hsa052230.15028004
163Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13514733
164Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11601935

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