LNX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.13272261
2vocalization behavior (GO:0071625)4.70744059
3locomotory exploration behavior (GO:0035641)4.70602867
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.36447588
5postsynaptic membrane organization (GO:0001941)4.27729369
6presynaptic membrane assembly (GO:0097105)4.11406559
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.03186408
8response to pheromone (GO:0019236)4.00729845
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.91576596
10neurotransmitter-gated ion channel clustering (GO:0072578)3.87354571
11regulation of glutamate receptor signaling pathway (GO:1900449)3.86691073
12synaptic vesicle exocytosis (GO:0016079)3.82880890
13neuronal action potential propagation (GO:0019227)3.79493230
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.73471898
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.73143447
16regulation of synaptic vesicle exocytosis (GO:2000300)3.66289558
17L-amino acid import (GO:0043092)3.63009045
18negative regulation of dendrite morphogenesis (GO:0050774)3.57550754
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.55387992
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.54953351
21presynaptic membrane organization (GO:0097090)3.50770569
22neurotransmitter secretion (GO:0007269)3.47803130
23glutamate secretion (GO:0014047)3.42515121
24exploration behavior (GO:0035640)3.40618243
25protein localization to synapse (GO:0035418)3.31500565
26positive regulation of synapse maturation (GO:0090129)3.31442021
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.30860587
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30702439
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30493952
30regulation of dendritic spine morphogenesis (GO:0061001)3.29986854
31regulation of synaptic plasticity (GO:0048167)3.25872073
32righting reflex (GO:0060013)3.25437489
33positive regulation of dendritic spine morphogenesis (GO:0061003)3.24514787
34membrane hyperpolarization (GO:0060081)3.23794978
35amino acid import (GO:0043090)3.17232547
36regulation of synaptic vesicle transport (GO:1902803)3.15692880
37cell communication by electrical coupling (GO:0010644)3.14721531
38long-chain fatty acid biosynthetic process (GO:0042759)3.13836241
39cellular potassium ion homeostasis (GO:0030007)3.11707335
40innervation (GO:0060384)3.11555432
41positive regulation of synaptic transmission, GABAergic (GO:0032230)3.11520312
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.11327897
43positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.10532313
44long-term synaptic potentiation (GO:0060291)3.10354401
45keratinization (GO:0031424)3.06873850
46synaptic vesicle maturation (GO:0016188)3.04243217
47neurotransmitter transport (GO:0006836)3.03634742
48startle response (GO:0001964)3.02846443
49synaptic transmission, glutamatergic (GO:0035249)3.02843414
50apical protein localization (GO:0045176)3.01385513
51positive regulation of synapse assembly (GO:0051965)3.01051842
52detection of calcium ion (GO:0005513)3.00537358
53neuronal ion channel clustering (GO:0045161)3.00525245
54regulation of dendritic spine development (GO:0060998)2.99427946
55gamma-aminobutyric acid transport (GO:0015812)2.98971757
56neuron-neuron synaptic transmission (GO:0007270)2.95722805
57protein targeting to Golgi (GO:0000042)2.94893965
58glutamate receptor signaling pathway (GO:0007215)2.93692085
59positive regulation of dendritic spine development (GO:0060999)2.92928274
60regulation of neurotransmitter transport (GO:0051588)2.92173806
61regulation of synaptic transmission, glutamatergic (GO:0051966)2.92134957
62cell communication involved in cardiac conduction (GO:0086065)2.91742679
63serotonin metabolic process (GO:0042428)2.89574908
64regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88083198
65cerebellar granule cell differentiation (GO:0021707)2.87977890
66regulation of cAMP-dependent protein kinase activity (GO:2000479)2.87874426
67positive regulation of neurotransmitter secretion (GO:0001956)2.86531649
68dendritic spine morphogenesis (GO:0060997)2.85836038
69negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85796937
70proline transport (GO:0015824)2.83948785
71regulation of vesicle fusion (GO:0031338)2.82773758
72central nervous system myelination (GO:0022010)2.79607916
73axon ensheathment in central nervous system (GO:0032291)2.79607916
74regulation of calcium ion-dependent exocytosis (GO:0017158)2.78806259
75synaptic vesicle docking involved in exocytosis (GO:0016081)2.78804676
76vesicle docking involved in exocytosis (GO:0006904)2.77390659
77regulation of ARF protein signal transduction (GO:0032012)2.75933977
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75560321
79positive regulation of membrane potential (GO:0045838)2.74949041
80layer formation in cerebral cortex (GO:0021819)2.74210862
81activation of protein kinase A activity (GO:0034199)2.74155909
82cellular sodium ion homeostasis (GO:0006883)2.72371441
83membrane depolarization during action potential (GO:0086010)2.72370223
84regulation of neurotransmitter levels (GO:0001505)2.71853024
85sodium ion export (GO:0071436)2.69834461
86negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.68606833
87negative regulation of dendrite development (GO:2000171)2.67662407
88chemosensory behavior (GO:0007635)2.67229070
89neuromuscular synaptic transmission (GO:0007274)2.66856103
90regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.65789270
91dendritic spine organization (GO:0097061)2.65615731
92alanine transport (GO:0032328)2.65112732
93regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.64698127
94retrograde transport, vesicle recycling within Golgi (GO:0000301)2.64696782
95axonal fasciculation (GO:0007413)2.64297585
96vesicle docking (GO:0048278)2.64109504
97regulation of synapse maturation (GO:0090128)2.63650719
98cytoskeletal anchoring at plasma membrane (GO:0007016)2.62479196
99transmission of nerve impulse (GO:0019226)2.61793857
100behavioral response to ethanol (GO:0048149)2.61456003
101glycosphingolipid biosynthetic process (GO:0006688)2.61438775
102regulation of cell communication by electrical coupling (GO:0010649)2.61082666
103positive regulation of neurotransmitter transport (GO:0051590)2.60962147
104cerebellar Purkinje cell differentiation (GO:0021702)2.59471935
105synaptic transmission (GO:0007268)2.57573249
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.57156292
107synaptic vesicle endocytosis (GO:0048488)2.56559184
108long term synaptic depression (GO:0060292)2.56543545
109synapse assembly (GO:0007416)2.56504060
110potassium ion import (GO:0010107)2.54683050
111regulation of synaptic transmission (GO:0050804)2.54149281
112establishment of protein localization to Golgi (GO:0072600)2.53894335
113neurotransmitter uptake (GO:0001504)2.53492428
114regulation of dendrite morphogenesis (GO:0048814)2.53087589
115regulation of sodium ion transmembrane transporter activity (GO:2000649)2.51695143
116long-term memory (GO:0007616)2.51441170
117regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.50048224
118response to auditory stimulus (GO:0010996)2.49211892
119neuromuscular process controlling posture (GO:0050884)2.48272634
120striatum development (GO:0021756)2.47784525
121regulation of neuronal synaptic plasticity (GO:0048168)2.47700665
122gonadal mesoderm development (GO:0007506)2.47689450
123potassium ion homeostasis (GO:0055075)2.47391611
124auditory receptor cell stereocilium organization (GO:0060088)2.47285070
125regulation of voltage-gated calcium channel activity (GO:1901385)2.46294774
126regulation of neurotransmitter secretion (GO:0046928)2.44662613
127cell differentiation in hindbrain (GO:0021533)2.44232788
128positive regulation of potassium ion transmembrane transport (GO:1901381)2.43649385
129response to histamine (GO:0034776)2.42336876
130regulation of respiratory system process (GO:0044065)2.41982716
131regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.41838385
132auditory behavior (GO:0031223)2.41662407
133regulation of synaptic transmission, GABAergic (GO:0032228)2.41301694
134regulation of long-term neuronal synaptic plasticity (GO:0048169)2.40808618
135positive regulation of synaptic transmission (GO:0050806)2.40673244
136regulation of excitatory postsynaptic membrane potential (GO:0060079)2.40657914
137membrane depolarization (GO:0051899)2.40263239
138cochlea development (GO:0090102)2.39833509
139energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.39442299
140ATP hydrolysis coupled proton transport (GO:0015991)2.39442299
141neuron recognition (GO:0008038)2.38810861
142negative regulation of synaptic transmission (GO:0050805)2.38387671
143regulation of synapse structural plasticity (GO:0051823)2.37697005
144multicellular organismal signaling (GO:0035637)2.37689690
145regulation of postsynaptic membrane potential (GO:0060078)2.37029366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.99459285
2GBX2_23144817_ChIP-Seq_PC3_Human3.83338539
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99140040
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89637639
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68428036
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56810707
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49852686
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49852686
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48000311
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42813862
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41883030
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35293463
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.34245602
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33433863
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.30835473
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.18983925
17REST_21632747_ChIP-Seq_MESCs_Mouse2.14938927
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13293215
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.00011141
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97712297
21DROSHA_22980978_ChIP-Seq_HELA_Human1.96792048
22AR_21572438_ChIP-Seq_LNCaP_Human1.96490682
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91186183
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87210127
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86079107
26* TAF15_26573619_Chip-Seq_HEK293_Human1.76242693
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75428535
28SMAD4_21799915_ChIP-Seq_A2780_Human1.69022701
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.66239436
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61366140
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57849054
32VDR_22108803_ChIP-Seq_LS180_Human1.57395747
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56404055
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55501255
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.53520616
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.51357640
37* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50918603
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49894925
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47088156
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45018741
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.43425996
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.42541507
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42406730
44* P300_19829295_ChIP-Seq_ESCs_Human1.38317450
45ZNF274_21170338_ChIP-Seq_K562_Hela1.37062295
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.36860481
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35285152
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33374437
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32515644
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.32345219
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32236692
52AR_25329375_ChIP-Seq_VCAP_Human1.30601813
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29768034
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27649119
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.27163968
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.26959777
57* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26266622
58* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26266622
59AHR_22903824_ChIP-Seq_MCF-7_Human1.26126413
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24081592
61CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23905052
62BCAT_22108803_ChIP-Seq_LS180_Human1.22376140
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.20552358
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19639355
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17199099
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17150501
67* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17065717
68STAT3_23295773_ChIP-Seq_U87_Human1.16547768
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15626299
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15185732
71* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15183286
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.14491417
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12887248
74TP53_18474530_ChIP-ChIP_U2OS_Human1.12558486
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.07459950
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06305109
77AR_19668381_ChIP-Seq_PC3_Human1.06148132
78FUS_26573619_Chip-Seq_HEK293_Human1.05644149
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04894566
80* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04630146
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04271136
82* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03527901
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02891618
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01857542
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01657830
86ER_23166858_ChIP-Seq_MCF-7_Human1.01321152
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01202166
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00693006
89* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99250992
90* TCF4_23295773_ChIP-Seq_U87_Human0.99140498
91KDM2B_26808549_Chip-Seq_REH_Human0.99021620
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98442488
93* RUNX2_22187159_ChIP-Seq_PCA_Human0.98102263
94* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98080845
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97688461
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.97656938
97P53_22387025_ChIP-Seq_ESCs_Mouse0.97624734
98RNF2_27304074_Chip-Seq_NSC_Mouse0.96752426
99CMYC_18555785_Chip-Seq_ESCs_Mouse0.96391528
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96127475
101IGF1R_20145208_ChIP-Seq_DFB_Human0.94679829
102EP300_21415370_ChIP-Seq_HL-1_Mouse0.94665346
103PRDM14_20953172_ChIP-Seq_ESCs_Human0.94122213
104* SMAD3_21741376_ChIP-Seq_HESCs_Human0.93502774
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92098355
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90663123
107* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90355961
108* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88536612
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.88234154
110* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87994211
111NANOG_18555785_Chip-Seq_ESCs_Mouse0.87151368
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86383583
113RING1B_27294783_Chip-Seq_NPCs_Mouse0.86334766
114TCF4_22108803_ChIP-Seq_LS180_Human0.86101529
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85893526
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85202666
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84619853
118TCF4_18268006_ChIP-ChIP_LS174T_Human0.84445630
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84161123
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83943010
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82022838
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82022838
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.81221934

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.06871833
2MP0004859_abnormal_synaptic_plasticity3.45806591
3MP0003635_abnormal_synaptic_transmissio2.96830728
4MP0009745_abnormal_behavioral_response2.64676147
5MP0009780_abnormal_chondrocyte_physiolo2.62718035
6MP0002822_catalepsy2.61602416
7MP0004270_analgesia2.57423164
8MP0009046_muscle_twitch2.55924693
9MP0002064_seizures2.48257069
10MP0001486_abnormal_startle_reflex2.44986622
11MP0001968_abnormal_touch/_nociception2.35809023
12MP0002837_dystrophic_cardiac_calcinosis2.34574728
13MP0005646_abnormal_pituitary_gland2.33003372
14MP0002272_abnormal_nervous_system2.29635539
15MP0001501_abnormal_sleep_pattern2.27922459
16MP0002063_abnormal_learning/memory/cond2.27620105
17MP0004043_abnormal_pH_regulation2.20448543
18MP0010234_abnormal_vibrissa_follicle2.17857046
19MP0002572_abnormal_emotion/affect_behav2.16226189
20MP0005423_abnormal_somatic_nervous2.15013661
21MP0002734_abnormal_mechanical_nocicepti2.12364636
22MP0003941_abnormal_skin_development2.12021896
23MP0005645_abnormal_hypothalamus_physiol2.03161407
24MP0002736_abnormal_nociception_after2.01327262
25MP0003183_abnormal_peptide_metabolism1.89177108
26MP0004858_abnormal_nervous_system1.88228548
27MP0004147_increased_porphyrin_level1.87267432
28MP0002067_abnormal_sensory_capabilities1.87070061
29MP0001502_abnormal_circadian_rhythm1.78180524
30MP0002557_abnormal_social/conspecific_i1.73606427
31MP0002733_abnormal_thermal_nociception1.71636054
32MP0002735_abnormal_chemical_nociception1.71330795
33MP0001440_abnormal_grooming_behavior1.71302163
34MP0006072_abnormal_retinal_apoptosis1.69229617
35MP0005551_abnormal_eye_electrophysiolog1.68311089
36MP0010386_abnormal_urinary_bladder1.67973415
37MP0002909_abnormal_adrenal_gland1.64106992
38MP0001529_abnormal_vocalization1.61931952
39MP0001984_abnormal_olfaction1.60856045
40MP0001970_abnormal_pain_threshold1.60384767
41MP0004215_abnormal_myocardial_fiber1.60138575
42MP0000013_abnormal_adipose_tissue1.59492463
43MP0002184_abnormal_innervation1.44551764
44MP0003879_abnormal_hair_cell1.42816219
45MP0008877_abnormal_DNA_methylation1.39908549
46MP0006276_abnormal_autonomic_nervous1.39076025
47MP0004742_abnormal_vestibular_system1.37959607
48MP0005386_behavior/neurological_phenoty1.37731799
49MP0004924_abnormal_behavior1.37731799
50MP0003787_abnormal_imprinting1.32378811
51MP0008569_lethality_at_weaning1.30947024
52MP0004142_abnormal_muscle_tone1.24060241
53MP0005379_endocrine/exocrine_gland_phen1.22756735
54MP0001664_abnormal_digestion1.19540833
55MP0003283_abnormal_digestive_organ1.18817537
56MP0000751_myopathy1.17672243
57MP0002638_abnormal_pupillary_reflex1.16999710
58MP0002066_abnormal_motor_capabilities/c1.13279905
59MP0003868_abnormal_feces_composition1.10038733
60MP0004085_abnormal_heartbeat1.09968612
61MP0000920_abnormal_myelination1.08273455
62MP0002876_abnormal_thyroid_physiology1.07308126
63MP0003329_amyloid_beta_deposits1.07050133
64MP0001666_abnormal_nutrient_absorption1.06188861
65MP0002090_abnormal_vision1.05532380
66MP0000462_abnormal_digestive_system1.05331461
67MP0002882_abnormal_neuron_morphology1.03711431
68MP0005535_abnormal_body_temperature1.03505678
69MP0001963_abnormal_hearing_physiology1.01842768
70MP0010678_abnormal_skin_adnexa1.01696661
71MP0002796_impaired_skin_barrier1.01653027
72MP0000955_abnormal_spinal_cord1.01246304
73MP0002229_neurodegeneration0.98404705
74MP0004145_abnormal_muscle_electrophysio0.98201034
75MP0004885_abnormal_endolymph0.97626643
76MP0003633_abnormal_nervous_system0.96681263
77MP0000631_abnormal_neuroendocrine_gland0.94567836
78MP0000778_abnormal_nervous_system0.94538167
79MP0005253_abnormal_eye_physiology0.93439228
80MP0003137_abnormal_impulse_conducting0.92355179
81MP0004036_abnormal_muscle_relaxation0.90326301
82MP0001485_abnormal_pinna_reflex0.89510268
83MP0002139_abnormal_hepatobiliary_system0.88736213
84MP0005171_absent_coat_pigmentation0.86815747
85MP0002069_abnormal_eating/drinking_beha0.84835111
86MP0001188_hyperpigmentation0.84490559
87MP0004811_abnormal_neuron_physiology0.84002523
88MP0000537_abnormal_urethra_morphology0.83777562
89MP0003136_yellow_coat_color0.81842596
90MP0003122_maternal_imprinting0.79870241
91MP0000026_abnormal_inner_ear0.79334744
92MP0003890_abnormal_embryonic-extraembry0.77454350
93MP0008872_abnormal_physiological_respon0.77160127
94MP0001905_abnormal_dopamine_level0.76248511
95MP0004084_abnormal_cardiac_muscle0.74626303
96MP0003631_nervous_system_phenotype0.74511675
97MP0000003_abnormal_adipose_tissue0.73595027
98MP0003634_abnormal_glial_cell0.73217086
99MP0001765_abnormal_ion_homeostasis0.72733689
100MP0000639_abnormal_adrenal_gland0.70642906
101MP0000467_abnormal_esophagus_morphology0.70082714
102MP0002752_abnormal_somatic_nervous0.70035092
103MP0002078_abnormal_glucose_homeostasis0.69865774
104MP0002152_abnormal_brain_morphology0.69594131
105MP0003690_abnormal_glial_cell0.68431119
106MP0000230_abnormal_systemic_arterial0.68069969
107MP0000383_abnormal_hair_follicle0.67578908
108MP0004019_abnormal_vitamin_homeostasis0.66645752
109MP0005275_abnormal_skin_tensile0.65537407
110MP0002693_abnormal_pancreas_physiology0.64844664
111MP0000538_abnormal_urinary_bladder0.64715035
112MP0001177_atelectasis0.64494108
113MP0002163_abnormal_gland_morphology0.64097872
114MP0001299_abnormal_eye_distance/0.63828642
115MP0003123_paternal_imprinting0.63567557
116MP0004484_altered_response_of0.62984369
117MP0001756_abnormal_urination0.57737698
118MP0005365_abnormal_bile_salt0.57665286
119MP0005367_renal/urinary_system_phenotyp0.57568696
120MP0000516_abnormal_urinary_system0.57568696
121MP0005085_abnormal_gallbladder_physiolo0.57464093
122MP0010769_abnormal_survival0.54100926
123MP0002082_postnatal_lethality0.52529049
124MP0010770_preweaning_lethality0.52529049
125MP0010768_mortality/aging0.51889239
126MP0002089_abnormal_postnatal_growth/wei0.50278627
127MP0010771_integument_phenotype0.49593522

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.57004782
2Febrile seizures (HP:0002373)4.07570943
3Epileptic encephalopathy (HP:0200134)4.05018446
4Myokymia (HP:0002411)4.01497873
5Atonic seizures (HP:0010819)3.85444598
6Visual hallucinations (HP:0002367)3.68576351
7Hyperventilation (HP:0002883)3.67157836
8Focal seizures (HP:0007359)3.54235624
9Papilledema (HP:0001085)3.52660730
10Congenital sensorineural hearing impairment (HP:0008527)3.44293732
11Absence seizures (HP:0002121)3.39757611
12Pheochromocytoma (HP:0002666)3.30135754
13Generalized tonic-clonic seizures (HP:0002069)3.22853284
14Impaired vibration sensation in the lower limbs (HP:0002166)2.99756932
15Abnormality of the corticospinal tract (HP:0002492)2.98555779
16Progressive cerebellar ataxia (HP:0002073)2.97620084
17Neuroendocrine neoplasm (HP:0100634)2.90737053
18Central scotoma (HP:0000603)2.88386361
19Limb dystonia (HP:0002451)2.87504990
20Synostosis involving the elbow (HP:0003938)2.87428696
21Humeroradial synostosis (HP:0003041)2.87428696
22Degeneration of the lateral corticospinal tracts (HP:0002314)2.87150266
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.87150266
24Urinary bladder sphincter dysfunction (HP:0002839)2.84896205
25Dialeptic seizures (HP:0011146)2.84335423
26Oligodactyly (hands) (HP:0001180)2.81775419
27Dysmetria (HP:0001310)2.78375474
28Abnormality of the lower motor neuron (HP:0002366)2.77382180
29Urinary urgency (HP:0000012)2.74973869
30Intention tremor (HP:0002080)2.72242590
31Ventricular fibrillation (HP:0001663)2.70014955
32Neoplasm of the peripheral nervous system (HP:0100007)2.65273729
33Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.63315423
34Spastic gait (HP:0002064)2.57771943
35Acute necrotizing encephalopathy (HP:0006965)2.54569118
36Split foot (HP:0001839)2.51709889
37Prolonged QT interval (HP:0001657)2.44166224
38Menstrual irregularities (HP:0000858)2.42962383
39Syncope (HP:0001279)2.42766449
40Abnormality of macular pigmentation (HP:0008002)2.42469227
41Congenital stationary night blindness (HP:0007642)2.42060472
42Impaired vibratory sensation (HP:0002495)2.41637276
43Epileptiform EEG discharges (HP:0011182)2.40611179
44Abnormal mitochondria in muscle tissue (HP:0008316)2.40226332
45Torticollis (HP:0000473)2.40191519
46EEG with generalized epileptiform discharges (HP:0011198)2.38649472
47Action tremor (HP:0002345)2.38307415
48Anxiety (HP:0000739)2.36686635
49Akinesia (HP:0002304)2.34084100
50Hemiparesis (HP:0001269)2.29361665
51Right ventricular cardiomyopathy (HP:0011663)2.24777849
52Lower limb muscle weakness (HP:0007340)2.22972726
53Hypsarrhythmia (HP:0002521)2.20899104
54Ketoacidosis (HP:0001993)2.18850794
55Supranuclear gaze palsy (HP:0000605)2.18361959
56Blue irides (HP:0000635)2.17723894
57Hyperinsulinemic hypoglycemia (HP:0000825)2.17389412
58Progressive macrocephaly (HP:0004481)2.16698543
59Symptomatic seizures (HP:0011145)2.16376348
60Acute encephalopathy (HP:0006846)2.16306744
61Gaze-evoked nystagmus (HP:0000640)2.14905744
62Hypothermia (HP:0002045)2.10466369
63Dysdiadochokinesis (HP:0002075)2.08291216
64Papillary thyroid carcinoma (HP:0002895)2.07031067
65Abnormal eating behavior (HP:0100738)2.03728164
66Testicular neoplasm (HP:0010788)2.02473322
67Postural instability (HP:0002172)2.00564752
68Status epilepticus (HP:0002133)1.99506655
69Clonus (HP:0002169)1.99426373
70Scanning speech (HP:0002168)1.99425443
71Palpitations (HP:0001962)1.99279967
72Decreased circulating renin level (HP:0003351)1.98377647
73Labial hypoplasia (HP:0000066)1.98004177
74Symphalangism affecting the phalanges of the hand (HP:0009773)1.97058085
75Sensorimotor neuropathy (HP:0007141)1.95904179
76Morphological abnormality of the pyramidal tract (HP:0002062)1.95462627
77Insulin-resistant diabetes mellitus (HP:0000831)1.94584914
78Truncal ataxia (HP:0002078)1.94248525
79Optic disc pallor (HP:0000543)1.94050328
80Drooling (HP:0002307)1.92892849
81Excessive salivation (HP:0003781)1.92892849
82Depression (HP:0000716)1.92234655
83Amyotrophic lateral sclerosis (HP:0007354)1.91699770
84Gait ataxia (HP:0002066)1.91564287
85Broad-based gait (HP:0002136)1.91554362
86Abnormal EKG (HP:0003115)1.91342498
87Hammertoe (HP:0001765)1.90694684
88Mutism (HP:0002300)1.89438722
89Agitation (HP:0000713)1.88656901
90Abnormality of calcium-phosphate metabolism (HP:0100530)1.88609873
91Gait imbalance (HP:0002141)1.86790752
92Polyphagia (HP:0002591)1.86448856
93Exercise-induced myalgia (HP:0003738)1.86209323
94Hypoglycemic seizures (HP:0002173)1.85999739
95Oligomenorrhea (HP:0000876)1.85635744
96Bundle branch block (HP:0011710)1.84907811
97Retinal dysplasia (HP:0007973)1.84422084
98Termporal pattern (HP:0011008)1.83119281
99Insidious onset (HP:0003587)1.83119281
100Neoplasm of head and neck (HP:0012288)1.82744296
101Esophageal neoplasm (HP:0100751)1.82744296
102Progressive inability to walk (HP:0002505)1.82469355
103Fibular aplasia (HP:0002990)1.82364386
104Cerebral hypomyelination (HP:0006808)1.82285687
105Poor suck (HP:0002033)1.81645399
106Decreased lacrimation (HP:0000633)1.80979379
107Hypoplastic nipples (HP:0002557)1.79741397
108Alacrima (HP:0000522)1.79150907
109Mitochondrial inheritance (HP:0001427)1.78542503
110Hyperactive renin-angiotensin system (HP:0000841)1.78518934
111Bronchomalacia (HP:0002780)1.78057134
112Generalized myoclonic seizures (HP:0002123)1.78046720
113Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77392782
114Gonadotropin excess (HP:0000837)1.77286639
115Ankle clonus (HP:0011448)1.76758720
116Delusions (HP:0000746)1.76069492
117Scotoma (HP:0000575)1.75571760
118Absent speech (HP:0001344)1.75338459
119Gonadal dysgenesis (HP:0000133)1.75189177
120Hyperaldosteronism (HP:0000859)1.74996366
121Neurofibrillary tangles (HP:0002185)1.74474265
122Metabolic alkalosis (HP:0200114)1.73509385
123Aplasia involving bones of the upper limbs (HP:0009823)1.73035671
124Aplasia of the phalanges of the hand (HP:0009802)1.73035671
125Aplasia involving bones of the extremities (HP:0009825)1.73035671
126Focal dystonia (HP:0004373)1.72976833
127Impaired smooth pursuit (HP:0007772)1.72954862
128Abnormality of ocular smooth pursuit (HP:0000617)1.72323847
129Fetal akinesia sequence (HP:0001989)1.71894684
130Abnormal social behavior (HP:0012433)1.71446021
131Impaired social interactions (HP:0000735)1.71446021
132Growth hormone excess (HP:0000845)1.71074059
133White forelock (HP:0002211)1.70100379
134Poor eye contact (HP:0000817)1.69869413
135Bradykinesia (HP:0002067)1.69499614
136Dysmetric saccades (HP:0000641)1.68963879
137Heterochromia iridis (HP:0001100)1.68868742
138Sudden death (HP:0001699)1.68253380
139Vaginal atresia (HP:0000148)1.67742174
140Increased circulating renin level (HP:0000848)1.67422563
141Genital tract atresia (HP:0001827)1.67016340
142Congenital primary aphakia (HP:0007707)1.65695741
143Hypoplastic female external genitalia (HP:0012815)1.65256024
144Morphological abnormality of the middle ear (HP:0008609)1.65243486
145Bradycardia (HP:0001662)1.65038387
146Abnormality of renin-angiotensin system (HP:0000847)1.64863681
147Abnormality of binocular vision (HP:0011514)1.64134902
148Diplopia (HP:0000651)1.64134902
149Genetic anticipation (HP:0003743)1.63562031
150Male infertility (HP:0003251)1.62485814
151Hyperkalemia (HP:0002153)1.59709495
152Obstructive sleep apnea (HP:0002870)1.56985109
153Megalencephaly (HP:0001355)1.55472299
154Tracheomalacia (HP:0002779)1.54925607
155Craniofacial dystonia (HP:0012179)1.53542408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.99079086
2NTRK33.98807488
3MAP3K42.71623474
4INSRR2.43134081
5MAPK152.27914400
6LMTK22.25935226
7MAP3K122.13680162
8MAP2K72.00180375
9PHKG21.96961274
10PHKG11.96961274
11AKT31.85434508
12PDGFRA1.77175592
13MARK11.72753418
14MAP2K41.70986841
15DAPK21.68194354
16ACVR1B1.66282891
17MAP3K91.64084990
18EPHA41.62186910
19CDK191.57905263
20WNK41.56001652
21NTRK11.53989110
22NTRK21.50455766
23GRK51.49482627
24MINK11.47203787
25MAP3K21.39327004
26CDC42BPA1.38387188
27FRK1.34166419
28CAMK1G1.34106519
29FER1.29981117
30NME11.26825391
31LATS21.26006878
32CAMK1D1.24998019
33PAK61.24966492
34TNIK1.16413487
35DAPK11.14449831
36GRK71.13759221
37PRKD31.13577563
38CDK51.13273320
39CAMK2D1.09643941
40PAK31.08390882
41CAMK2A1.08080159
42TYRO31.07718378
43TAOK11.05785924
44SGK2231.04973925
45SGK4941.04973925
46PRKCG1.00308800
47BCR0.96847083
48RIPK10.96777989
49WNK30.96160537
50PRKCE0.95303660
51WNK10.94795688
52PDK20.92853542
53PDK30.88701527
54PDK40.88701527
55NEK60.85920310
56CAMK2B0.84752734
57MAPK130.84738507
58SGK20.83290757
59SIK20.82300169
60OXSR10.82117467
61STK380.80109188
62KSR20.79567664
63ARAF0.79156113
64MAP3K10.78942314
65STK390.78680888
66ERBB40.77853483
67BMPR20.77097488
68MAP3K60.76788218
69CAMK2G0.74994397
70UHMK10.74276102
71RET0.74117600
72EIF2AK30.72931923
73MUSK0.72513508
74MAP3K130.71745253
75LATS10.71470086
76PIK3CA0.70190848
77STK38L0.70161352
78MYLK0.69878664
79TNK20.68460836
80ERBB30.68276379
81PNCK0.67614688
82CAMK10.67291209
83PRKG20.66488559
84PDPK10.66296578
85CAMKK10.66100520
86DMPK0.65149649
87EPHA20.64764857
88SGK30.64356607
89ADRBK10.62497456
90SGK10.61108175
91CCNB10.61061512
92BRAF0.60120548
93DYRK1A0.59273790
94PRKACA0.58604456
95ADRBK20.57896242
96PRKCZ0.57071132
97ROCK10.54630311
98CSNK1G20.54296888
99NEK90.53999840
100BMPR1B0.53942308
101CAMKK20.53578500
102PRKCH0.53368723
103CDK180.52906417
104PRKCA0.52851510
105PKN10.52376957
106STK240.52007209
107TESK10.51760460
108PLK20.50878365
109PRPF4B0.50402118
110ROCK20.49690531
111CDK150.49690527
112MST40.49588669
113MAPK100.48922213
114RPS6KA30.47988084
115PRKG10.47730705
116MAP2K20.45596993
117MAPK70.44604933
118MAP3K70.44009953
119RPS6KA20.43925523
120MARK20.43846760
121CAMK40.43606260
122PDK10.43518263
123MAP2K10.42806192
124PINK10.42432082
125YES10.42309738
126CDK11A0.42201617
127STK110.42114613
128MAPKAPK50.41402751
129PRKAA10.41383415
130EPHA30.40645359
131ALK0.38047592

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.37496383
2Synaptic vesicle cycle_Homo sapiens_hsa047212.71706730
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40554997
4GABAergic synapse_Homo sapiens_hsa047272.40503986
5Insulin secretion_Homo sapiens_hsa049112.24755398
6Collecting duct acid secretion_Homo sapiens_hsa049662.09142843
7Morphine addiction_Homo sapiens_hsa050321.99119654
8Circadian entrainment_Homo sapiens_hsa047131.97660348
9Oxidative phosphorylation_Homo sapiens_hsa001901.92961123
10Cardiac muscle contraction_Homo sapiens_hsa042601.85352852
11Amphetamine addiction_Homo sapiens_hsa050311.82971317
12Taste transduction_Homo sapiens_hsa047421.78850398
13Salivary secretion_Homo sapiens_hsa049701.76035975
14Glutamatergic synapse_Homo sapiens_hsa047241.75060858
15Olfactory transduction_Homo sapiens_hsa047401.69803394
16Sulfur metabolism_Homo sapiens_hsa009201.64607128
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64591391
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.64070309
19Renin secretion_Homo sapiens_hsa049241.59278243
20Dopaminergic synapse_Homo sapiens_hsa047281.57806173
21Vibrio cholerae infection_Homo sapiens_hsa051101.56836112
22Cocaine addiction_Homo sapiens_hsa050301.52370184
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52105336
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49134731
25Serotonergic synapse_Homo sapiens_hsa047261.46254487
26Gastric acid secretion_Homo sapiens_hsa049711.45700515
27Long-term potentiation_Homo sapiens_hsa047201.38184052
28Parkinsons disease_Homo sapiens_hsa050121.36654688
29Cholinergic synapse_Homo sapiens_hsa047251.34158918
30Alzheimers disease_Homo sapiens_hsa050101.33275791
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32733562
32Type II diabetes mellitus_Homo sapiens_hsa049301.31257183
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29924883
34Calcium signaling pathway_Homo sapiens_hsa040201.27997297
35Long-term depression_Homo sapiens_hsa047301.25031665
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23248829
37Vitamin B6 metabolism_Homo sapiens_hsa007501.20791215
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17124227
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16205320
40Butanoate metabolism_Homo sapiens_hsa006501.14998555
41Oxytocin signaling pathway_Homo sapiens_hsa049211.10826585
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06203681
43Pancreatic secretion_Homo sapiens_hsa049721.05677874
44Dilated cardiomyopathy_Homo sapiens_hsa054141.00520154
45Gap junction_Homo sapiens_hsa045400.98738789
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97812398
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95663397
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95155638
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93413601
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92617883
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91343556
52Mineral absorption_Homo sapiens_hsa049780.91338500
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91216227
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91201425
55GnRH signaling pathway_Homo sapiens_hsa049120.90651159
56Tight junction_Homo sapiens_hsa045300.89637474
57Oocyte meiosis_Homo sapiens_hsa041140.89454014
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86071411
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.83323173
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82027729
61cAMP signaling pathway_Homo sapiens_hsa040240.80684155
62Bile secretion_Homo sapiens_hsa049760.79580495
63Thyroid hormone synthesis_Homo sapiens_hsa049180.77945347
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76411522
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75931792
66Pyruvate metabolism_Homo sapiens_hsa006200.74744266
67Huntingtons disease_Homo sapiens_hsa050160.73287004
68Phototransduction_Homo sapiens_hsa047440.72744036
69Ras signaling pathway_Homo sapiens_hsa040140.70885799
70Circadian rhythm_Homo sapiens_hsa047100.70454519
71Estrogen signaling pathway_Homo sapiens_hsa049150.70275291
72Fructose and mannose metabolism_Homo sapiens_hsa000510.70244731
73Phenylalanine metabolism_Homo sapiens_hsa003600.70162002
74Galactose metabolism_Homo sapiens_hsa000520.68645209
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67564970
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66051468
77Arginine biosynthesis_Homo sapiens_hsa002200.66033934
78Glioma_Homo sapiens_hsa052140.65922228
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.65422523
80Fat digestion and absorption_Homo sapiens_hsa049750.65392993
81Propanoate metabolism_Homo sapiens_hsa006400.64765569
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64733972
83Protein digestion and absorption_Homo sapiens_hsa049740.59968796
84Ovarian steroidogenesis_Homo sapiens_hsa049130.58295331
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56753962
86Rap1 signaling pathway_Homo sapiens_hsa040150.56611953
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56166148
88Melanogenesis_Homo sapiens_hsa049160.56085905
89Ether lipid metabolism_Homo sapiens_hsa005650.55652930
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55364646
91Dorso-ventral axis formation_Homo sapiens_hsa043200.55099613
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.54769302
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54591765
94Linoleic acid metabolism_Homo sapiens_hsa005910.54200974
95Axon guidance_Homo sapiens_hsa043600.52678752
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52423976
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52000929
98Type I diabetes mellitus_Homo sapiens_hsa049400.51360905
99Sphingolipid metabolism_Homo sapiens_hsa006000.51230076
100Glycerolipid metabolism_Homo sapiens_hsa005610.50864457
101Glucagon signaling pathway_Homo sapiens_hsa049220.50609344
102Arginine and proline metabolism_Homo sapiens_hsa003300.50406121
103Fatty acid metabolism_Homo sapiens_hsa012120.50242946
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50007624
105Fatty acid degradation_Homo sapiens_hsa000710.49917507
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49179988
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48818691
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48802321
109beta-Alanine metabolism_Homo sapiens_hsa004100.48784586
110Adherens junction_Homo sapiens_hsa045200.48637603
111Histidine metabolism_Homo sapiens_hsa003400.46730984
112Starch and sucrose metabolism_Homo sapiens_hsa005000.46673291
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46182749
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.44728302
115Choline metabolism in cancer_Homo sapiens_hsa052310.43789281
116Fatty acid biosynthesis_Homo sapiens_hsa000610.43281556
117Wnt signaling pathway_Homo sapiens_hsa043100.41677137
118ABC transporters_Homo sapiens_hsa020100.40801040
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40623489
120Tyrosine metabolism_Homo sapiens_hsa003500.40515164
121Rheumatoid arthritis_Homo sapiens_hsa053230.39828969
122AMPK signaling pathway_Homo sapiens_hsa041520.39691273
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39153802
124Hippo signaling pathway_Homo sapiens_hsa043900.37560015
125ErbB signaling pathway_Homo sapiens_hsa040120.37356205
126Inositol phosphate metabolism_Homo sapiens_hsa005620.37179042
127Nitrogen metabolism_Homo sapiens_hsa009100.37009343
128Tryptophan metabolism_Homo sapiens_hsa003800.36298210
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.36126600
130Insulin signaling pathway_Homo sapiens_hsa049100.35236579

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