LNX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fat-soluble vitamin biosynthetic process (GO:0042362)9.90492238
2vascular endothelial growth factor signaling pathway (GO:0038084)7.16111999
3response to pheromone (GO:0019236)6.23558525
4positive regulation of dendritic spine morphogenesis (GO:0061003)6.03543151
5bundle of His cell to Purkinje myocyte communication (GO:0086069)5.33160884
6exogenous drug catabolic process (GO:0042738)5.10248972
7desmosome organization (GO:0002934)5.05210160
8response to UV-C (GO:0010225)5.03200425
9definitive hemopoiesis (GO:0060216)5.02262631
10sprouting angiogenesis (GO:0002040)4.98585659
11vitamin transmembrane transport (GO:0035461)4.91214911
12heart trabecula formation (GO:0060347)4.84049109
13endothelium development (GO:0003158)4.82674282
14drug catabolic process (GO:0042737)4.79747806
15cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.69626628
16cellular glucuronidation (GO:0052695)4.63836318
17N-terminal protein amino acid acetylation (GO:0006474)4.45584305
18uronic acid metabolic process (GO:0006063)4.44896577
19glucuronate metabolic process (GO:0019585)4.44896577
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.41758458
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.41758458
22positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)4.36902791
23very-low-density lipoprotein particle assembly (GO:0034379)4.32846764
24intestinal epithelial cell development (GO:0060576)4.30721768
25negative regulation of endothelial cell apoptotic process (GO:2000352)4.28170787
26positive regulation of cell junction assembly (GO:1901890)4.12764477
27positive regulation of focal adhesion assembly (GO:0051894)4.12764477
28epoxygenase P450 pathway (GO:0019373)4.09702261
29positive regulation of lipid kinase activity (GO:0090218)4.05398733
30regulation of establishment or maintenance of cell polarity (GO:0032878)4.03038452
31establishment of endothelial barrier (GO:0061028)4.03015900
32monoubiquitinated protein deubiquitination (GO:0035520)4.01421943
33antigen processing and presentation of endogenous antigen (GO:0019883)3.96346041
34regulation of bile acid biosynthetic process (GO:0070857)3.93816047
35positive regulation of adherens junction organization (GO:1903393)3.92606451
36endothelial tube morphogenesis (GO:0061154)3.81876327
37morphogenesis of an endothelium (GO:0003159)3.81876327
38patterning of blood vessels (GO:0001569)3.70896646
39peptidyl-tyrosine autophosphorylation (GO:0038083)3.60890857
40lymph vessel development (GO:0001945)3.57728339
41vitamin biosynthetic process (GO:0009110)3.56918966
42nuclear pore complex assembly (GO:0051292)3.55991235
43positive regulation of actin cytoskeleton reorganization (GO:2000251)3.54948278
44exocrine pancreas development (GO:0031017)3.44909760
45flavonoid metabolic process (GO:0009812)3.41610992
46drug metabolic process (GO:0017144)3.36415227
47bile acid and bile salt transport (GO:0015721)3.34463993
48regulation of endothelial cell apoptotic process (GO:2000351)3.33300787
49plasma lipoprotein particle assembly (GO:0034377)3.32633820
50regulation of phosphatidylinositol 3-kinase activity (GO:0043551)3.30881575
51trabecula formation (GO:0060343)3.30532938
52bile acid metabolic process (GO:0008206)3.27627447
53vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.25301819
54positive regulation of gamma-delta T cell activation (GO:0046645)3.25132178
55iron ion import (GO:0097286)3.25116704
56protein targeting to Golgi (GO:0000042)3.24856899
57omega-hydroxylase P450 pathway (GO:0097267)3.22418382
58phospholipid efflux (GO:0033700)3.21687160
59high-density lipoprotein particle remodeling (GO:0034375)3.21156194
60hemidesmosome assembly (GO:0031581)3.16083558
61COPII vesicle coating (GO:0048208)3.16017733
62surfactant homeostasis (GO:0043129)3.15884508
63regulation of gamma-delta T cell differentiation (GO:0045586)3.15857699
64lung vasculature development (GO:0060426)3.15559293
65S-adenosylmethionine metabolic process (GO:0046500)3.11458099
66gap junction assembly (GO:0016264)3.09721844
67regulation of hippo signaling (GO:0035330)3.09064361
68negative regulation of fatty acid biosynthetic process (GO:0045717)3.06515296
69intestinal cholesterol absorption (GO:0030299)3.05868907
70female genitalia development (GO:0030540)3.01819104
71valine metabolic process (GO:0006573)2.99014969
72retrograde transport, vesicle recycling within Golgi (GO:0000301)2.98899066
73regulation of lipid kinase activity (GO:0043550)2.97333677
74drug transmembrane transport (GO:0006855)2.97253079
75regulation of protein activation cascade (GO:2000257)2.97184029
76embryonic foregut morphogenesis (GO:0048617)2.96985063
77lung lobe morphogenesis (GO:0060463)2.96253049
78ethanol oxidation (GO:0006069)2.95231648
79organ regeneration (GO:0031100)2.94673296
80positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.93649100
81regulation of gamma-delta T cell activation (GO:0046643)2.87964395
82piRNA metabolic process (GO:0034587)2.87766441
83monocyte chemotaxis (GO:0002548)2.87495356
84negative regulation of sterol transport (GO:0032372)2.87334680
85negative regulation of cholesterol transport (GO:0032375)2.87334680
86positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068)2.87033318
87biotin metabolic process (GO:0006768)2.86853180
88positive regulation of natural killer cell differentiation (GO:0032825)2.86605399
89endothelial cell proliferation (GO:0001935)2.86574805
90regulation of water loss via skin (GO:0033561)2.86423895
91amino-acid betaine transport (GO:0015838)2.84153732
92carnitine transport (GO:0015879)2.84153732
93nuclear pore organization (GO:0006999)2.83741084
94establishment of protein localization to Golgi (GO:0072600)2.81571334
95pentose-phosphate shunt (GO:0006098)2.80800714
96regulation of vascular permeability (GO:0043114)2.80615747
97regulation of complement activation (GO:0030449)2.80486155
98modified amino acid transport (GO:0072337)2.80038985
99establishment of skin barrier (GO:0061436)2.79330839
100positive regulation of hormone biosynthetic process (GO:0046886)2.78223770
101transcytosis (GO:0045056)2.77680286
102positive regulation of vasculogenesis (GO:2001214)2.77480120
103regulation of sequestering of triglyceride (GO:0010889)2.75993700
104transepithelial transport (GO:0070633)2.75124170
105positive regulation by host of viral transcription (GO:0043923)2.74514673
106peptidyl-glutamic acid carboxylation (GO:0017187)2.74333597
107protein carboxylation (GO:0018214)2.74333597
108blood vessel endothelial cell migration (GO:0043534)2.74180815
109carnitine transmembrane transport (GO:1902603)2.73435201
110oxidative demethylation (GO:0070989)2.72017041
111carnitine shuttle (GO:0006853)2.71840904
112protein-lipid complex assembly (GO:0065005)2.70255630
113ear development (GO:0043583)2.69762268
114chemical homeostasis within a tissue (GO:0048875)2.68736733
115cholesterol efflux (GO:0033344)2.68159003
116quaternary ammonium group transport (GO:0015697)2.67048736
117negative regulation of keratinocyte proliferation (GO:0010839)2.66739575
118response to laminar fluid shear stress (GO:0034616)2.66199000
119macroautophagy (GO:0016236)2.66197869
120endothelial cell development (GO:0001885)2.64894950
121sphingomyelin metabolic process (GO:0006684)2.62508250
122mRNA transcription from RNA polymerase II promoter (GO:0042789)2.62121482
123bile acid biosynthetic process (GO:0006699)2.62110449
124regulation of cardioblast differentiation (GO:0051890)2.61070656
125positive thymic T cell selection (GO:0045059)2.61056239
126regulation of transforming growth factor beta2 production (GO:0032909)2.60687475
127ethanol metabolic process (GO:0006067)2.60148731
128cell migration involved in sprouting angiogenesis (GO:0002042)2.59824745
129negative T cell selection (GO:0043383)2.59259120
130negative regulation of fibrinolysis (GO:0051918)2.57735698
131pore complex assembly (GO:0046931)2.57672241
132cholesterol homeostasis (GO:0042632)2.57215122
133urea cycle (GO:0000050)2.57189936
134urea metabolic process (GO:0019627)2.57189936
135anterior/posterior axis specification, embryo (GO:0008595)2.57081367
136negative regulation of vascular permeability (GO:0043116)2.56548476
137phenylpropanoid metabolic process (GO:0009698)2.56213541
138glyoxylate metabolic process (GO:0046487)2.55940879
139triglyceride homeostasis (GO:0070328)2.55771295
140acylglycerol homeostasis (GO:0055090)2.55771295
141reverse cholesterol transport (GO:0043691)2.55493120
142amino-acid betaine metabolic process (GO:0006577)2.54854029
143multicellular organismal water homeostasis (GO:0050891)2.54706673
144regulation of cholesterol homeostasis (GO:2000188)2.54488129
145sterol homeostasis (GO:0055092)2.54393112
146calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.53987370
147growth hormone receptor signaling pathway (GO:0060396)2.53533946
148tight junction assembly (GO:0070830)2.53376988
149nitrogen cycle metabolic process (GO:0071941)2.52850696
150mRNA transcription (GO:0009299)2.52650281
151germ cell migration (GO:0008354)2.52582587
152fatty acid transmembrane transport (GO:1902001)2.51513077
153negative thymic T cell selection (GO:0045060)2.50547227
154response to interleukin-15 (GO:0070672)2.49719875
155thymic T cell selection (GO:0045061)2.49288646
156cysteine metabolic process (GO:0006534)2.46913705
157regulation of triglyceride catabolic process (GO:0010896)2.46798753
158T cell selection (GO:0045058)2.45996694
159muscle atrophy (GO:0014889)2.45842291
160cytoplasmic mRNA processing body assembly (GO:0033962)2.45366959
161alkaloid metabolic process (GO:0009820)2.44180981
162protein-lipid complex remodeling (GO:0034368)2.43962118
163macromolecular complex remodeling (GO:0034367)2.43962118
164plasma lipoprotein particle remodeling (GO:0034369)2.43962118
165intestinal absorption (GO:0050892)2.42576485
166homocysteine metabolic process (GO:0050667)2.42249216
167positive regulation of humoral immune response (GO:0002922)2.41595798
168low-density lipoprotein particle clearance (GO:0034383)2.41559405
169tolerance induction (GO:0002507)2.41165247
170regulation of phosphatidylinositol 3-kinase signaling (GO:0014066)2.40834232
171erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.40695096
172L-phenylalanine catabolic process (GO:0006559)2.40695096
173positive regulation of cellular amide metabolic process (GO:0034250)2.40465343
174regulation of establishment of cell polarity (GO:2000114)2.40054776
175Notch signaling involved in heart development (GO:0061314)2.39997763
176hormone catabolic process (GO:0042447)2.39801485
177positive regulation of lipid catabolic process (GO:0050996)2.39761802
178regulation of fibrinolysis (GO:0051917)2.39360280
179positive regulation of fatty acid beta-oxidation (GO:0032000)2.38329126
180negative regulation of protein activation cascade (GO:2000258)2.38151924
181erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.38085350
182L-phenylalanine metabolic process (GO:0006558)2.38085350
183regulation of keratinocyte proliferation (GO:0010837)2.37976906
184regulation of centriole replication (GO:0046599)2.36278003
185lipid homeostasis (GO:0055088)2.35813771
186embryonic retina morphogenesis in camera-type eye (GO:0060059)2.35754025
187diaphragm development (GO:0060539)2.35033948
188labyrinthine layer development (GO:0060711)2.34751913

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.54718144
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.94150082
3E2F7_22180533_ChIP-Seq_HELA_Human3.87001424
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.64321641
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.35475462
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.18406627
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.96250138
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.95140347
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.75983045
10* RXR_22158963_ChIP-Seq_LIVER_Mouse2.69564369
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.67516958
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.59146071
13FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.55009679
14GATA4_25053715_ChIP-Seq_YYC3_Human2.52525757
15MYC_22102868_ChIP-Seq_BL_Human2.44523372
16* LXR_22158963_ChIP-Seq_LIVER_Mouse2.40306530
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.40150158
18DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.39540569
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.35406961
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34429280
21* AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.19189337
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.18666952
23FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.13940666
24CLOCK_20551151_ChIP-Seq_293T_Human2.10375723
25FOXM1_26456572_ChIP-Seq_MCF-7_Human1.98612815
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.97125633
27* FOXA1_25552417_ChIP-Seq_VCAP_Human1.95022409
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94295866
29RUNX_20019798_ChIP-Seq_JUKART_Human1.94048432
30UTX_26944678_Chip-Seq_JUKART_Human1.91497064
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.90067207
32ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.88810891
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.88524843
34SCL_19346495_ChIP-Seq_HPC-7_Human1.85347039
35AHR_22903824_ChIP-Seq_MCF-7_Human1.83453661
36* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.81966640
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.81245816
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78622211
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78317409
40GATA3_24758297_ChIP-Seq_MCF-7_Human1.78227456
41FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.76789343
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75245762
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72810041
44MAF_26560356_Chip-Seq_TH1_Human1.72615628
45* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70911211
46* TCF7_22412390_ChIP-Seq_EML_Mouse1.68056301
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67612418
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65514479
49MYB_26560356_Chip-Seq_TH1_Human1.62277347
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62115955
51* SOX2_20726797_ChIP-Seq_SW620_Human1.60924837
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60660202
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60380938
54MYB_26560356_Chip-Seq_TH2_Human1.59929355
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59314857
56AR_21909140_ChIP-Seq_LNCAP_Human1.58767098
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58696128
58VDR_22108803_ChIP-Seq_LS180_Human1.56703043
59IGF1R_20145208_ChIP-Seq_DFB_Human1.56217996
60CDX2_22108803_ChIP-Seq_LS180_Human1.55769459
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54357911
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52963929
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.52208985
64HNF4A_19822575_ChIP-Seq_HepG2_Human1.52158852
65* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50501472
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50096009
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49675977
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48778827
69TCF4_18268006_ChIP-ChIP_LS174T_Human1.47752993
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47367196
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45557696
72GATA1_22025678_ChIP-Seq_K562_Human1.43458175
73* MAF_26560356_Chip-Seq_TH2_Human1.42408146
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.39752812
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.38804349
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37787375
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37713862
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37702341
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.34108170
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31208334
81KDM2B_26808549_Chip-Seq_DND41_Human1.30872296
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28642338
83TP63_23658742_ChIP-Seq_EP156T_Human1.28611303
84ZNF263_19887448_ChIP-Seq_K562_Human1.27282731
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26086065
86ZNF274_21170338_ChIP-Seq_K562_Hela1.26070213
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26054159
88ER_23166858_ChIP-Seq_MCF-7_Human1.25761254
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25106415
90CHD1_26751641_Chip-Seq_LNCaP_Human1.24311925
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22674794
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21431524
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21215618
94GATA1_19941826_ChIP-Seq_K562_Human1.20564964
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19215339
96TBX20_22328084_ChIP-Seq_HEART_Mouse1.18783413
97TBX20_22080862_ChIP-Seq_HEART_Mouse1.18783413
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18235373
99* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18033482
100SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16666398
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15792568
102VDR_21846776_ChIP-Seq_THP-1_Human1.14739628
103* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14675374
104* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14398120
105* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.13761245
106TP53_16413492_ChIP-PET_HCT116_Human1.13468591
107RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13463625
108RUNX1_22412390_ChIP-Seq_EML_Mouse1.12390923
109FOXA2_19822575_ChIP-Seq_HepG2_Human1.12137298
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.11497684
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10723478
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10595117
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09395039
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08786249
115FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07940464
116IRF8_27001747_Chip-Seq_BMDM_Mouse1.07592381
117* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06425234
118* ESR1_20079471_ChIP-ChIP_T-47D_Human1.05964330
119GATA6_25053715_ChIP-Seq_YYC3_Human1.05232068
120* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04164651
121* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04164651
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04100419
123RUNX1_27514584_Chip-Seq_MCF-7_Human1.03375536
124* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02824430
125BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02713054
126STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02654823
127SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02475337
128* STAT3_23295773_ChIP-Seq_U87_Human1.01482515
129FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00829635
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99762099
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99678275
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99561456
133TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98419424
134GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98410363
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98408887
136GATA3_27048872_Chip-Seq_THYMUS_Human0.98019439
137EP300_21415370_ChIP-Seq_HL-1_Mouse0.97748561
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97719856
139* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97637753
140PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97546072
141SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97278107
142RACK7_27058665_Chip-Seq_MCF-7_Human0.96732896
143CJUN_26792858_Chip-Seq_BT549_Human0.96365416
144* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95822199
145ATF3_27146783_Chip-Seq_COLON_Human0.95353189
146PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94445099
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94226729
148KDM2B_26808549_Chip-Seq_JURKAT_Human0.93808847
149IRF1_19129219_ChIP-ChIP_H3396_Human0.93549316
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93300691
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92983887
152NCOR1_26117541_ChIP-Seq_K562_Human0.92522229
153ESR2_21235772_ChIP-Seq_MCF-7_Human0.92091462
154* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92060945
155ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91965454
156NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89618374
157NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89618374
158* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86807493
159* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84273537
160KLF5_25053715_ChIP-Seq_YYC3_Human0.84176571
161KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84137585
162HOXB7_26014856_ChIP-Seq_BT474_Human0.83810684
163* FUS_26573619_Chip-Seq_HEK293_Human0.82849300
164TAF15_26573619_Chip-Seq_HEK293_Human0.82425695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.70725917
2MP0004264_abnormal_extraembryonic_tissu3.21108388
3MP0010678_abnormal_skin_adnexa2.87079669
4MP0001873_stomach_inflammation2.83169237
5MP0000383_abnormal_hair_follicle2.68711068
6MP0002796_impaired_skin_barrier2.63158250
7MP0006138_congestive_heart_failure2.55758029
8MP0003941_abnormal_skin_development2.52711679
9MP0005365_abnormal_bile_salt2.48383641
10MP0010368_abnormal_lymphatic_system2.45444347
11MP0005360_urolithiasis2.39255566
12MP0003806_abnormal_nucleotide_metabolis2.38914829
13MP0001879_abnormal_lymphatic_vessel2.33033201
14MP0002138_abnormal_hepatobiliary_system2.31350894
15MP0002166_altered_tumor_susceptibility2.26939636
16MP0005083_abnormal_biliary_tract2.22506097
17MP0002009_preneoplasia2.19939217
18MP0002098_abnormal_vibrissa_morphology2.18805599
19MP0005085_abnormal_gallbladder_physiolo2.17617866
20MP0004147_increased_porphyrin_level2.14180793
21MP0003195_calcinosis2.12351566
22MP0003300_gastrointestinal_ulcer2.09779863
23MP0003183_abnormal_peptide_metabolism2.05275903
24MP0003763_abnormal_thymus_physiology2.02946889
25MP0005670_abnormal_white_adipose2.01889206
26MP0002139_abnormal_hepatobiliary_system1.98144374
27MP0003890_abnormal_embryonic-extraembry1.89871318
28MP0003724_increased_susceptibility_to1.88629399
29MP0000566_synostosis1.86891659
30MP0005167_abnormal_blood-brain_barrier1.80951297
31MP0003705_abnormal_hypodermis_morpholog1.79780755
32MP0003868_abnormal_feces_composition1.78987018
33MP0003878_abnormal_ear_physiology1.75866968
34MP0005377_hearing/vestibular/ear_phenot1.75866968
35MP0001915_intracranial_hemorrhage1.70451431
36MP0002006_tumorigenesis1.67816864
37MP0009278_abnormal_bone_marrow1.65580531
38MP0006054_spinal_hemorrhage1.65244093
39MP0000685_abnormal_immune_system1.65205332
40MP0003943_abnormal_hepatobiliary_system1.64543380
41MP0003252_abnormal_bile_duct1.63062519
42MP0002396_abnormal_hematopoietic_system1.61593288
43MP0009840_abnormal_foam_cell1.59335387
44MP0009697_abnormal_copulation1.56663671
45MP0005076_abnormal_cell_differentiation1.56202359
46MP0005451_abnormal_body_composition1.56065204
47MP0004019_abnormal_vitamin_homeostasis1.56045424
48MP0000579_abnormal_nail_morphology1.54168546
49MP0005501_abnormal_skin_physiology1.53408073
50MP0010329_abnormal_lipoprotein_level1.49666167
51MP0005332_abnormal_amino_acid1.49179140
52MP0000427_abnormal_hair_cycle1.47138102
53MP0001800_abnormal_humoral_immune1.45369449
54MP0005387_immune_system_phenotype1.43295016
55MP0001790_abnormal_immune_system1.43295016
56MP0003828_pulmonary_edema1.38428161
57MP0009333_abnormal_splenocyte_physiolog1.35166834
58MP0010630_abnormal_cardiac_muscle1.31658056
59MP0000462_abnormal_digestive_system1.31489280
60MP0005165_increased_susceptibility_to1.31353806
61MP0002877_abnormal_melanocyte_morpholog1.29425099
62MP0005397_hematopoietic_system_phenotyp1.29083233
63MP0001545_abnormal_hematopoietic_system1.29083233
64MP0010352_gastrointestinal_tract_polyps1.28997227
65MP0003693_abnormal_embryo_hatching1.28289004
66MP0008875_abnormal_xenobiotic_pharmacok1.28065776
67MP0003567_abnormal_fetal_cardiomyocyte1.26084248
68MP0000767_abnormal_smooth_muscle1.25245130
69MP0001835_abnormal_antigen_presentation1.24439216
70MP0001666_abnormal_nutrient_absorption1.23805218
71MP0008007_abnormal_cellular_replicative1.23395157
72MP0004484_altered_response_of1.20525669
73MP0003566_abnormal_cell_adhesion1.20502765
74MP0005409_darkened_coat_color1.20338113
75MP0003436_decreased_susceptibility_to1.18533782
76MP0000613_abnormal_salivary_gland1.17873579
77MP0002452_abnormal_antigen_presenting1.17536623
78MP0010155_abnormal_intestine_physiology1.16413419
79MP0002876_abnormal_thyroid_physiology1.16169218
80MP0001216_abnormal_epidermal_layer1.14910571
81MP0003718_maternal_effect1.14159470
82MP0000609_abnormal_liver_physiology1.13699829
83MP0002086_abnormal_extraembryonic_tissu1.12360542
84MP0008961_abnormal_basal_metabolism1.12122061
85MP0004957_abnormal_blastocyst_morpholog1.11630782
86MP0004272_abnormal_basement_membrane1.10038482
87MP0005385_cardiovascular_system_phenoty1.08564423
88MP0001544_abnormal_cardiovascular_syste1.08564423
89MP0002420_abnormal_adaptive_immunity1.08509625
90MP0002398_abnormal_bone_marrow1.08452482
91MP0001819_abnormal_immune_cell1.06397084
92MP0008057_abnormal_DNA_replication1.06267880
93MP0004808_abnormal_hematopoietic_stem1.05908123
94MP0003283_abnormal_digestive_organ1.04774359
95MP0002925_abnormal_cardiovascular_devel1.04727929
96MP0002128_abnormal_blood_circulation1.03579142
97MP0000377_abnormal_hair_follicle1.03142875
98MP0009643_abnormal_urine_homeostasis1.02620805
99MP0005671_abnormal_response_to1.01793983
100MP0002429_abnormal_blood_cell1.00980207
101MP0000249_abnormal_blood_vessel0.99146109
102MP0005636_abnormal_mineral_homeostasis0.98706980
103MP0002723_abnormal_immune_serum0.97688324
104MP0000598_abnormal_liver_morphology0.97066966
105MP0000537_abnormal_urethra_morphology0.96323509
106MP0002118_abnormal_lipid_homeostasis0.96214474
107MP0004043_abnormal_pH_regulation0.96085033
108MP0003866_abnormal_defecation0.95172760
109MP0000689_abnormal_spleen_morphology0.94948588
110MP0005666_abnormal_adipose_tissue0.94853418
111MP0000716_abnormal_immune_system0.94649314
112MP0000703_abnormal_thymus_morphology0.93737350
113MP0002722_abnormal_immune_system0.93220821
114MP0000467_abnormal_esophagus_morphology0.91826807
115MP0003656_abnormal_erythrocyte_physiolo0.91448862
116MP0010771_integument_phenotype0.91286697
117MP0000627_abnormal_mammary_gland0.91279051
118MP0000733_abnormal_muscle_development0.91143893
119MP0001730_embryonic_growth_arrest0.89159672
120MP0002405_respiratory_system_inflammati0.87753946
121MP0003091_abnormal_cell_migration0.87447346
122MP0003303_peritoneal_inflammation0.86301271
123MP0002136_abnormal_kidney_physiology0.86091684
124MP0001661_extended_life_span0.85367529
125MP0008995_early_reproductive_senescence0.85232607
126MP0000762_abnormal_tongue_morphology0.84996671
127MP0005084_abnormal_gallbladder_morpholo0.84706169
128MP0005000_abnormal_immune_tolerance0.84559796
129MP0002088_abnormal_embryonic_growth/wei0.84454966
130MP0005220_abnormal_exocrine_pancreas0.83785128
131MP0004947_skin_inflammation0.82766054
132MP0001614_abnormal_blood_vessel0.82550073
133MP0003984_embryonic_growth_retardation0.81602192
134MP0009763_increased_sensitivity_to0.80390794
135MP0005023_abnormal_wound_healing0.79922136
136MP0001845_abnormal_inflammatory_respons0.79687763
137MP0004233_abnormal_muscle_weight0.79227613
138MP0002108_abnormal_muscle_morphology0.77915389
139MP0003453_abnormal_keratinocyte_physiol0.77625022
140MP0004185_abnormal_adipocyte_glucose0.77276158
141MP0001784_abnormal_fluid_regulation0.76611491
142MP0002254_reproductive_system_inflammat0.75871857
143MP0001765_abnormal_ion_homeostasis0.75265177
144MP0005380_embryogenesis_phenotype0.75208699
145MP0001672_abnormal_embryogenesis/_devel0.75208699
146MP0009115_abnormal_fat_cell0.74872003
147MP0004782_abnormal_surfactant_physiolog0.74690527
148MP0002060_abnormal_skin_morphology0.74165511
149MP0000266_abnormal_heart_morphology0.74142912
150MP0003638_abnormal_response/metabolism_0.73308943
151MP0009384_cardiac_valve_regurgitation0.71694584
152MP0000477_abnormal_intestine_morphology0.71517301
153MP0005408_hypopigmentation0.71269349
154MP0002089_abnormal_postnatal_growth/wei0.71044018
155MP0002084_abnormal_developmental_patter0.68810699
156MP0000470_abnormal_stomach_morphology0.67319573
157MP0000647_abnormal_sebaceous_gland0.65408084
158MP0005647_abnormal_sex_gland0.64472153
159MP0009703_decreased_birth_body0.63953869
160MP0001697_abnormal_embryo_size0.63566736
161MP0009780_abnormal_chondrocyte_physiolo0.62612645
162MP0003950_abnormal_plasma_membrane0.62253710
163MP0004197_abnormal_fetal_growth/weight/0.60024683
164MP0005395_other_phenotype0.57948355

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.91761213
2Hypobetalipoproteinemia (HP:0003563)4.70928197
3Hyperinsulinemic hypoglycemia (HP:0000825)4.58872714
4Esophageal varix (HP:0002040)4.33732566
5Hypoglycemic coma (HP:0001325)3.98726879
6Autoimmune thrombocytopenia (HP:0001973)3.81092868
7Hypoglycemic seizures (HP:0002173)3.68007230
8Microretrognathia (HP:0000308)3.66996511
9Hyperglycinuria (HP:0003108)3.60842052
10Fat malabsorption (HP:0002630)3.49439779
11Petechiae (HP:0000967)3.44298760
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.39561964
13Deep venous thrombosis (HP:0002625)3.36932615
14Annular pancreas (HP:0001734)3.35472743
15Acanthocytosis (HP:0001927)3.31914403
16Abnormal biliary tract morphology (HP:0012440)3.25286333
17Adactyly (HP:0009776)3.23944967
18Conjugated hyperbilirubinemia (HP:0002908)3.19501913
19Symptomatic seizures (HP:0011145)3.13587643
20Hydroxyprolinuria (HP:0003080)3.02125226
21Abnormality of proline metabolism (HP:0010907)3.02125226
22Proximal tubulopathy (HP:0000114)3.01936374
23Abnormality of serine family amino acid metabolism (HP:0010894)2.93882420
24Abnormality of glycine metabolism (HP:0010895)2.93882420
25Biliary tract neoplasm (HP:0100574)2.93760681
26Vascular calcification (HP:0004934)2.93457146
27Persistence of primary teeth (HP:0006335)2.90623428
28Poikilocytosis (HP:0004447)2.90507568
29Tetany (HP:0001281)2.90335168
30Fair hair (HP:0002286)2.90082056
31Aplasia/Hypoplasia of the spleen (HP:0010451)2.88035993
32Decreased circulating renin level (HP:0003351)2.85864839
33Joint hemorrhage (HP:0005261)2.85312613
34Polycythemia (HP:0001901)2.84625533
35Pancreatic islet-cell hyperplasia (HP:0004510)2.81445264
36Panhypogammaglobulinemia (HP:0003139)2.78624982
37Abnormality of the fingertips (HP:0001211)2.76853674
38Increased CSF protein (HP:0002922)2.76005361
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.74536147
40Hypoplastic labia majora (HP:0000059)2.72013765
41Lip pit (HP:0100267)2.67948016
42Abnormality of fatty-acid metabolism (HP:0004359)2.66829345
43Absent hand (HP:0004050)2.66083745
44Abnormal pancreas size (HP:0012094)2.65796464
45Abnormality of chloride homeostasis (HP:0011422)2.64114311
46Abnormality of nail color (HP:0100643)2.63500209
47Recurrent viral infections (HP:0004429)2.62678567
48Abnormality of T cell physiology (HP:0011840)2.60217114
49Intrahepatic cholestasis (HP:0001406)2.59917341
50Skull defect (HP:0001362)2.56645502
51Flat acetabular roof (HP:0003180)2.56262430
52Myocardial infarction (HP:0001658)2.55297826
53Portal hypertension (HP:0001409)2.54987394
54Colitis (HP:0002583)2.52082411
55Hypolipoproteinemia (HP:0010981)2.52071441
56Steatorrhea (HP:0002570)2.51667951
57Hyperkalemia (HP:0002153)2.51370356
58Xanthomatosis (HP:0000991)2.50733182
59Spontaneous hematomas (HP:0007420)2.49134224
60Abnormality of the common coagulation pathway (HP:0010990)2.48764459
61Curly hair (HP:0002212)2.48741206
62Nonimmune hydrops fetalis (HP:0001790)2.48276366
63Abnormality of the hepatic vasculature (HP:0006707)2.42137814
64Prolonged partial thromboplastin time (HP:0003645)2.41569948
65Acute myeloid leukemia (HP:0004808)2.38801595
66Azoospermia (HP:0000027)2.36292515
67Uterine leiomyosarcoma (HP:0002891)2.34977325
68Leiomyosarcoma (HP:0100243)2.34977325
69Abnormality of the pancreatic islet cells (HP:0006476)2.34091163
70Abnormality of endocrine pancreas physiology (HP:0012093)2.34091163
71Mesangial abnormality (HP:0001966)2.33730526
72Abnormality of the aortic arch (HP:0012303)2.33283494
73Abnormality of the labia majora (HP:0012881)2.32210934
74Cardiovascular calcification (HP:0011915)2.31434265
75Germ cell neoplasia (HP:0100728)2.30830101
76Osteomalacia (HP:0002749)2.29495101
77Malnutrition (HP:0004395)2.28969578
78Abnormality of vitamin metabolism (HP:0100508)2.27817401
79Plantar hyperkeratosis (HP:0007556)2.26824106
80Epidermoid cyst (HP:0200040)2.26568109
81Abnormality of the gastric mucosa (HP:0004295)2.26055208
82Abnormality of T cells (HP:0002843)2.25821822
83Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.24608847
84Onycholysis (HP:0001806)2.22933107
85Papillary thyroid carcinoma (HP:0002895)2.22587245
86Milia (HP:0001056)2.19508616
87Abnormality of the nasal mucosa (HP:0000433)2.18660066
88Abnormality of the nasal septum (HP:0000419)2.18493254
89Inflammation of the large intestine (HP:0002037)2.18486405
90Gastrointestinal inflammation (HP:0004386)2.16544906
91Septate vagina (HP:0001153)2.13779375
92Abnormality of the salivary glands (HP:0010286)2.13483959
93Lymphangioma (HP:0100764)2.11228627
94Porencephaly (HP:0002132)2.09790807
95Abnormality of the axillary hair (HP:0100134)2.09512587
96Abnormality of secondary sexual hair (HP:0009888)2.09512587
97Transitional cell carcinoma of the bladder (HP:0006740)2.08258634
98Ileus (HP:0002595)2.07749768
99Agammaglobulinemia (HP:0004432)2.07572473
100Generalized hypopigmentation of hair (HP:0011358)2.07099670
101Pseudobulbar signs (HP:0002200)2.06432470
102Cortical dysplasia (HP:0002539)2.04444576
103Breast carcinoma (HP:0003002)2.03886436
104Cutis marmorata (HP:0000965)2.03146476
105Hypothermia (HP:0002045)2.02935583
106Abnormality of the intrinsic pathway (HP:0010989)2.02840904
107Rickets (HP:0002748)2.02593400
108Recurrent fungal infections (HP:0002841)2.01502747
109Abnormality of the peritoneum (HP:0002585)2.01501197
110Rectal prolapse (HP:0002035)2.00611591
111Abnormal hair laboratory examination (HP:0003328)1.99045572
112Birth length less than 3rd percentile (HP:0003561)1.98611205
113Hypoplasia of the uterus (HP:0000013)1.97697679
114Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95926051
115Malignant gastrointestinal tract tumors (HP:0006749)1.95781878
116Gastrointestinal carcinoma (HP:0002672)1.95781878
117Intellectual disability, profound (HP:0002187)1.95428874
118Ectopic kidney (HP:0000086)1.95246838
119Woolly hair (HP:0002224)1.94800104
120Hyperactive renin-angiotensin system (HP:0000841)1.94427535
121Abnormality of renin-angiotensin system (HP:0000847)1.93833491
122Abnormal platelet function (HP:0011869)1.93734147
123Impaired platelet aggregation (HP:0003540)1.93734147
124Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93054668
125Hyperglycinemia (HP:0002154)1.92566791
126Hematochezia (HP:0002573)1.92220580
127Clitoromegaly (HP:0000057)1.91823857
128Pigmentary retinal degeneration (HP:0001146)1.91271915
129Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90057826
130Exocrine pancreatic insufficiency (HP:0001738)1.88684555
131Palmar hyperkeratosis (HP:0010765)1.86821503
132Glycosuria (HP:0003076)1.85806843
133Abnormality of urine glucose concentration (HP:0011016)1.85806843
134Palmoplantar hyperkeratosis (HP:0000972)1.85559957
135Long eyelashes (HP:0000527)1.84687975
136Bicornuate uterus (HP:0000813)1.84321944
137Spontaneous abortion (HP:0005268)1.82952843
138Hypoplasia of dental enamel (HP:0006297)1.82836228
139Abnormality of iron homeostasis (HP:0011031)1.82351882
140Scrotal hypoplasia (HP:0000046)1.82330118
141Hyperammonemia (HP:0001987)1.81144903
142Labial hypoplasia (HP:0000066)1.80928495
143Pulmonary embolism (HP:0002204)1.80465871
144Spastic diplegia (HP:0001264)1.80105791
145Abnormality of serum amino acid levels (HP:0003112)1.79141098
146Nasal polyposis (HP:0100582)1.79086973
147Bladder carcinoma (HP:0002862)1.77786096
148Bladder neoplasm (HP:0009725)1.77786096
149Fragile nails (HP:0001808)1.77538838
150Autoimmune hemolytic anemia (HP:0001890)1.77485336
151Chronic otitis media (HP:0000389)1.76357254
152Pili torti (HP:0003777)1.76342038
153Tubular atrophy (HP:0000092)1.76315965
154Abnormality of methionine metabolism (HP:0010901)1.76061368
155Abnormality of T cell number (HP:0011839)1.75531579
156Depressed nasal tip (HP:0000437)1.75480781
157Metabolic acidosis (HP:0001942)1.75036684
158Dehydration (HP:0001944)1.74525748
159Joint swelling (HP:0001386)1.74357638
160Abnormality of pyrimidine metabolism (HP:0004353)1.74254843
161Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74246825
162Chronic mucocutaneous candidiasis (HP:0002728)1.74189400
163Recurrent cutaneous fungal infections (HP:0011370)1.74189400
164Abnormality of transition element cation homeostasis (HP:0011030)1.74056612
165Prominent nose (HP:0000448)1.73807327
166Ovarian neoplasm (HP:0100615)1.73282081
167Narrow palate (HP:0000189)1.72969011
168Arterial thrombosis (HP:0004420)1.72887820
169Arteriovenous malformation (HP:0100026)1.72584987
170Abnormality of potassium homeostasis (HP:0011042)1.72348510
171Complement deficiency (HP:0004431)1.72335531
172Neoplasm of the small intestine (HP:0100833)1.72024617
173Viral hepatitis (HP:0006562)1.71738556
174Hand muscle atrophy (HP:0009130)1.70934455
175Late onset (HP:0003584)1.70819082
176Thrombophlebitis (HP:0004418)1.70058462
177Tetraparesis (HP:0002273)1.69879303
178Hemorrhage of the eye (HP:0011885)1.69781441
179T lymphocytopenia (HP:0005403)1.68724665
180Abnormality of the dental root (HP:0006486)1.67952114
181Taurodontia (HP:0000679)1.67952114
182Abnormality of permanent molar morphology (HP:0011071)1.67952114
183Abnormality of sulfur amino acid metabolism (HP:0004339)1.67448976
184Focal segmental glomerulosclerosis (HP:0000097)1.66375852
185Alopecia of scalp (HP:0002293)1.66314352
186Abnormal cartilage morphology (HP:0002763)1.66111177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.07311535
2KDR3.40453159
3MST1R3.12260154
4LMTK22.98357021
5TEC2.82700555
6GRK12.69179287
7CAMK1D2.68584549
8MST42.64920185
9BMX2.51268557
10BRSK22.23493860
11MET2.20986692
12STK242.04680356
13WNK42.02616335
14STK38L2.00964681
15SCYL22.00872277
16TIE112.7408801
17OXSR11.93884674
18CAMK1G1.84302811
19MAP4K11.83768959
20FRK1.74517652
21MAP3K21.64215575
22FER1.64140899
23TAF11.54366701
24EEF2K1.53910124
25FGFR41.49286541
26STK101.45927484
27EIF2AK31.37687390
28INSRR1.37580008
29CDK121.29309422
30TSSK61.25788694
31JAK31.20769041
32MAPKAPK31.15655404
33ZAK1.13445508
34SIK11.10006935
35TRIB31.06109603
36WNK11.05623349
37FLT31.01863099
38TAOK31.00497754
39TGFBR20.97731759
40MAP3K120.96205254
41PKN20.94657198
42TYK20.93049822
43TXK0.92363563
44MAP3K100.91613519
45ERN10.91386421
46WEE10.89854043
47MUSK0.89262138
48ERBB20.88845990
49NLK0.88024856
50YES10.85167451
51TGFBR10.85027073
52BCR0.83748460
53FGFR20.82243167
54NEK90.82173850
55TRPM70.80851644
56ERBB30.80059378
57ZAP700.78217589
58JAK10.77693514
59MAP3K140.74479326
60ITK0.73121484
61PTK60.73116751
62OBSCN0.72398486
63PRKAA20.70808964
64EPHB10.70384436
65PBK0.69651085
66RPS6KB10.69451197
67PINK10.68477328
68MAP2K20.66984448
69PIK3CG0.65928778
70NEK60.65574729
71EPHA30.65125841
72MTOR0.64535012
73LRRK20.63853024
74RPS6KB20.63272804
75ICK0.60827904
76NUAK10.59794595
77FGFR30.59418052
78TTN0.59380142
79LATS10.59269345
80SGK30.59118470
81PNCK0.58755423
82PRKG20.57291315
83DYRK30.57205684
84CHUK0.57144295
85CLK10.55262262
86BMPR1B0.53885838
87CDK60.51784356
88IKBKE0.51744735
89SGK20.51627477
90PRKCE0.51459670
91MKNK20.50293515
92KIT0.49184254
93EIF2AK10.48701306
94LATS20.48335292
95MAPK110.46247141
96EIF2AK20.45544813
97GRK60.45434981
98PIM10.44755046
99IKBKB0.44143453
100PLK10.43724318
101CDK40.42004322
102TBK10.41468202
103CAMK40.40603889
104WNK30.40232264
105EGFR0.39978222
106ACVR1B0.39976758
107JAK20.37964763
108PLK40.37853963
109CSK0.37490174
110MAP3K80.37216184
111RPS6KA40.35922771
112CDK90.35876171
113SMG10.35602477
114MAP3K30.34155493
115BCKDK0.32946231
116FGFR10.32917495
117EPHA20.32500862
118STK40.31908941
119PRKAA10.30908933
120RIPK10.30810570
121CHEK10.30734268
122TTK0.30587344
123BTK0.30480612
124BRD40.30367794
125PRKCI0.30061132
126CSNK1E0.29242362
127PDGFRA0.28896434
128TRIM280.28861096
129PDGFRB0.28822388
130MAP3K70.28643688
131MAP2K30.28604092
132IRAK10.28192207
133IGF1R0.26445798
134CSF1R0.26430197
135IRAK30.25842738
136MAPKAPK20.25825260
137MELK0.24914292
138PRKD20.24177410
139LCK0.23398457
140MAP3K130.23076058
141HCK0.22871182
142MARK30.21304827
143INSR0.21191803
144PIK3CA0.21010862
145CDK70.19843416
146DMPK0.19152729
147NEK20.18067264
148PASK0.17982879
149CDK80.17192292
150AKT30.16420624
151MAPK70.16396746
152STK30.16082766
153AKT20.14949306
154MAPK10.14347090

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73287247
2Retinol metabolism_Homo sapiens_hsa008302.41380279
3Linoleic acid metabolism_Homo sapiens_hsa005912.39216824
4Steroid hormone biosynthesis_Homo sapiens_hsa001402.35959475
5Primary immunodeficiency_Homo sapiens_hsa053402.32009671
6Bile secretion_Homo sapiens_hsa049762.17341077
7Chemical carcinogenesis_Homo sapiens_hsa052042.14010832
8PPAR signaling pathway_Homo sapiens_hsa033202.12505740
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.08281307
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01368403
11HIF-1 signaling pathway_Homo sapiens_hsa040661.97849751
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.95554781
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.94181460
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.92294295
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.86668250
16Adherens junction_Homo sapiens_hsa045201.85419994
17Starch and sucrose metabolism_Homo sapiens_hsa005001.82519786
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.70684644
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68527171
20Tryptophan metabolism_Homo sapiens_hsa003801.64634844
21Butanoate metabolism_Homo sapiens_hsa006501.64090987
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.59118206
23Fatty acid degradation_Homo sapiens_hsa000711.56739852
24Arginine biosynthesis_Homo sapiens_hsa002201.48375421
25Lysine degradation_Homo sapiens_hsa003101.47002189
26Antigen processing and presentation_Homo sapiens_hsa046121.46067385
27Notch signaling pathway_Homo sapiens_hsa043301.42116291
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41532456
29Renin-angiotensin system_Homo sapiens_hsa046141.38436598
30Nitrogen metabolism_Homo sapiens_hsa009101.38231401
31Ovarian steroidogenesis_Homo sapiens_hsa049131.37758045
32Complement and coagulation cascades_Homo sapiens_hsa046101.37138261
33Mineral absorption_Homo sapiens_hsa049781.35073282
34Small cell lung cancer_Homo sapiens_hsa052221.31459276
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.28007454
36Acute myeloid leukemia_Homo sapiens_hsa052211.23688309
37ABC transporters_Homo sapiens_hsa020101.19945466
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19921761
39Ether lipid metabolism_Homo sapiens_hsa005651.17618104
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15127490
41Toxoplasmosis_Homo sapiens_hsa051451.12855257
42Measles_Homo sapiens_hsa051621.12046737
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11142403
44Fatty acid biosynthesis_Homo sapiens_hsa000611.10952776
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.08889859
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.07124514
47Fatty acid metabolism_Homo sapiens_hsa012121.04909816
48Sulfur metabolism_Homo sapiens_hsa009201.04739128
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04641197
50Arginine and proline metabolism_Homo sapiens_hsa003301.04540981
51HTLV-I infection_Homo sapiens_hsa051661.03490645
52Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01469140
53Herpes simplex infection_Homo sapiens_hsa051681.01449056
54Steroid biosynthesis_Homo sapiens_hsa001001.00647053
55Selenocompound metabolism_Homo sapiens_hsa004501.00252893
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99412060
57Viral myocarditis_Homo sapiens_hsa054160.97935258
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97467282
59beta-Alanine metabolism_Homo sapiens_hsa004100.97278887
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96073690
61Arachidonic acid metabolism_Homo sapiens_hsa005900.93892084
62Protein digestion and absorption_Homo sapiens_hsa049740.93842429
63Fructose and mannose metabolism_Homo sapiens_hsa000510.93716059
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93283021
65Staphylococcus aureus infection_Homo sapiens_hsa051500.92861625
66Phenylalanine metabolism_Homo sapiens_hsa003600.91753194
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90539018
68Insulin resistance_Homo sapiens_hsa049310.90349785
69Pancreatic secretion_Homo sapiens_hsa049720.89771692
70Chronic myeloid leukemia_Homo sapiens_hsa052200.89194482
71Pyruvate metabolism_Homo sapiens_hsa006200.88564608
72Caffeine metabolism_Homo sapiens_hsa002320.88357013
73Glycerolipid metabolism_Homo sapiens_hsa005610.87679335
74T cell receptor signaling pathway_Homo sapiens_hsa046600.87408808
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87407724
76B cell receptor signaling pathway_Homo sapiens_hsa046620.86842507
77Fat digestion and absorption_Homo sapiens_hsa049750.86411985
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.86102370
79MicroRNAs in cancer_Homo sapiens_hsa052060.85855159
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84780873
81One carbon pool by folate_Homo sapiens_hsa006700.80652277
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78587905
83Peroxisome_Homo sapiens_hsa041460.77764968
84Sphingolipid metabolism_Homo sapiens_hsa006000.77263177
85Rheumatoid arthritis_Homo sapiens_hsa053230.77015859
86Prostate cancer_Homo sapiens_hsa052150.76848084
87Hepatitis B_Homo sapiens_hsa051610.75327622
88p53 signaling pathway_Homo sapiens_hsa041150.74688871
89Hematopoietic cell lineage_Homo sapiens_hsa046400.74381019
90Thyroid cancer_Homo sapiens_hsa052160.73127050
91Vitamin B6 metabolism_Homo sapiens_hsa007500.72047626
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72029588
93Rap1 signaling pathway_Homo sapiens_hsa040150.71903443
94Hepatitis C_Homo sapiens_hsa051600.71057889
95AMPK signaling pathway_Homo sapiens_hsa041520.70651676
96Tight junction_Homo sapiens_hsa045300.70475639
97Pancreatic cancer_Homo sapiens_hsa052120.69682018
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69030831
99Circadian rhythm_Homo sapiens_hsa047100.67395794
100Vitamin digestion and absorption_Homo sapiens_hsa049770.67176353
101Leishmaniasis_Homo sapiens_hsa051400.66409040
102Biosynthesis of amino acids_Homo sapiens_hsa012300.65892883
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.65855970
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.65836905
105FoxO signaling pathway_Homo sapiens_hsa040680.65718017
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65594157
107TNF signaling pathway_Homo sapiens_hsa046680.65205607
108Focal adhesion_Homo sapiens_hsa045100.64540769
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63586981
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62950992
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62505929
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61914930
113Viral carcinogenesis_Homo sapiens_hsa052030.61453356
114TGF-beta signaling pathway_Homo sapiens_hsa043500.60833675
115Dorso-ventral axis formation_Homo sapiens_hsa043200.60236567
116Allograft rejection_Homo sapiens_hsa053300.59770792
117Influenza A_Homo sapiens_hsa051640.58550907
118Proteoglycans in cancer_Homo sapiens_hsa052050.56978377
119Folate biosynthesis_Homo sapiens_hsa007900.56856410
120Cell cycle_Homo sapiens_hsa041100.56841802
121Prolactin signaling pathway_Homo sapiens_hsa049170.56232966
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56155074
123Osteoclast differentiation_Homo sapiens_hsa043800.55741438
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55029823
125Tyrosine metabolism_Homo sapiens_hsa003500.54779792
126Apoptosis_Homo sapiens_hsa042100.54594828
127Renal cell carcinoma_Homo sapiens_hsa052110.54466945
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51554130
129Legionellosis_Homo sapiens_hsa051340.51227205
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50707591
131Platelet activation_Homo sapiens_hsa046110.50659958
132Pentose phosphate pathway_Homo sapiens_hsa000300.50143806
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49621010
134Inositol phosphate metabolism_Homo sapiens_hsa005620.49563575
135Histidine metabolism_Homo sapiens_hsa003400.49389360
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48824781
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47854228
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47660580
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47636984
140Propanoate metabolism_Homo sapiens_hsa006400.47399394
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47352985
142Pathways in cancer_Homo sapiens_hsa052000.45614450
143Carbon metabolism_Homo sapiens_hsa012000.45177483
144Metabolic pathways_Homo sapiens_hsa011000.41787064
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38783902
146Glucagon signaling pathway_Homo sapiens_hsa049220.33584826
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32300073
148Choline metabolism in cancer_Homo sapiens_hsa052310.30793275
149Hippo signaling pathway_Homo sapiens_hsa043900.30479979
150Endometrial cancer_Homo sapiens_hsa052130.28864805
151N-Glycan biosynthesis_Homo sapiens_hsa005100.27092982
152Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25429789
153Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24584195

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