LOC100421166

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1blood coagulation, intrinsic pathway (GO:0007597)6.09252326
2negative regulation of complement activation (GO:0045916)5.77211964
3retinal cone cell development (GO:0046549)5.70049455
4angiogenesis involved in wound healing (GO:0060055)5.68657418
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.51423217
6negative regulation of protein activation cascade (GO:2000258)5.34249210
7protein neddylation (GO:0045116)5.28897452
8response to magnesium ion (GO:0032026)5.27285518
9thrombin receptor signaling pathway (GO:0070493)5.20214471
10xenobiotic catabolic process (GO:0042178)4.90618703
11regulation of platelet activation (GO:0010543)4.78793139
12negative regulation of humoral immune response (GO:0002921)4.68272207
13regulation of platelet aggregation (GO:0090330)4.66991793
14negative regulation of platelet activation (GO:0010544)4.50722719
15lysine catabolic process (GO:0006554)4.40293896
16lysine metabolic process (GO:0006553)4.40293896
17neutrophil activation involved in immune response (GO:0002283)4.36407165
18regulation of integrin-mediated signaling pathway (GO:2001044)4.29860002
19negative regulation of protein localization to cell surface (GO:2000009)4.29856370
20negative regulation of heart rate (GO:0010459)4.23525176
21response to folic acid (GO:0051593)4.21703239
22reverse cholesterol transport (GO:0043691)4.19902277
23regulation of Golgi to plasma membrane protein transport (GO:0042996)4.19041710
24negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.04416816
25negative regulation of T-helper cell differentiation (GO:0045623)4.04416816
26response to misfolded protein (GO:0051788)4.00649243
27beta-amyloid metabolic process (GO:0050435)3.99415073
28negative regulation of norepinephrine secretion (GO:0010700)3.95752671
29positive regulation of synaptic transmission, GABAergic (GO:0032230)3.95441404
30alkaloid metabolic process (GO:0009820)3.86047612
31negative regulation of appetite (GO:0032099)3.85131546
32negative regulation of response to food (GO:0032096)3.85131546
33negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.84896018
34negative regulation of homotypic cell-cell adhesion (GO:0034111)3.84833192
35adenosine receptor signaling pathway (GO:0001973)3.83886037
36low-density lipoprotein particle remodeling (GO:0034374)3.77068323
37positive regulation of endothelial cell differentiation (GO:0045603)3.76579350
38positive regulation of cellular amide metabolic process (GO:0034250)3.73153797
39platelet degranulation (GO:0002576)3.71830257
40negative regulation of heart contraction (GO:0045822)3.66744061
41leukocyte migration involved in inflammatory response (GO:0002523)3.66448887
42vesicle targeting (GO:0006903)3.61564734
43regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.57889931
44regulation of lipoprotein metabolic process (GO:0050746)3.55923252
45neuronal action potential propagation (GO:0019227)3.55596375
46positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.52138856
47peptide catabolic process (GO:0043171)3.50015924
48platelet aggregation (GO:0070527)3.48339796
49negative regulation of protein oligomerization (GO:0032460)3.37300098
50regulation of amyloid precursor protein catabolic process (GO:1902991)3.35483970
51regulation of T-helper 2 cell differentiation (GO:0045628)3.34661006
52regulation of memory T cell differentiation (GO:0043380)3.30746485
53amino-acid betaine metabolic process (GO:0006577)3.29928848
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.29886238
55regulation of beta-amyloid formation (GO:1902003)3.28032266
56positive regulation of receptor recycling (GO:0001921)3.21165289
57regulation of endothelial cell differentiation (GO:0045601)3.17059505
58synaptonemal complex organization (GO:0070193)3.14914719
59platelet activation (GO:0030168)3.14724254
60G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.12738532
61positive regulation of coagulation (GO:0050820)3.11130735
62tonic smooth muscle contraction (GO:0014820)3.07161536
63synaptonemal complex assembly (GO:0007130)3.04143718
64high-density lipoprotein particle remodeling (GO:0034375)3.02811036
65regulation of complement activation (GO:0030449)3.02786032
66positive regulation of blood coagulation (GO:0030194)3.01173207
67positive regulation of hemostasis (GO:1900048)3.01173207
68postsynaptic membrane organization (GO:0001941)2.98528013
69activation of protein kinase A activity (GO:0034199)2.96560600
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.95447296
71purinergic nucleotide receptor signaling pathway (GO:0035590)2.92015386
72cGMP-mediated signaling (GO:0019934)2.90999171
73regulation of protein activation cascade (GO:2000257)2.89466232
74termination of G-protein coupled receptor signaling pathway (GO:0038032)2.88633544
75phospholipid homeostasis (GO:0055091)2.88290623
76regulation of macrophage derived foam cell differentiation (GO:0010743)2.87921183
77eosinophil chemotaxis (GO:0048245)2.84724387
78platelet formation (GO:0030220)2.83600941
79regulation of hemostasis (GO:1900046)2.79735727
80regulation of blood coagulation (GO:0030193)2.79735727
81cellular biogenic amine catabolic process (GO:0042402)2.78873328
82amine catabolic process (GO:0009310)2.78873328
83response to gravity (GO:0009629)2.76380619
84positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.75758855
85neurotransmitter uptake (GO:0001504)2.75219683
86protein activation cascade (GO:0072376)2.74094138
87negative regulation of blood circulation (GO:1903523)2.73495209
88negative regulation of muscle contraction (GO:0045932)2.73257905
89termination of signal transduction (GO:0023021)2.71953949
90regulation of female receptivity (GO:0045924)2.71273758
91regulation of cAMP-dependent protein kinase activity (GO:2000479)2.69926501
92lipoxygenase pathway (GO:0019372)2.69471661
93negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.69440402
94fusion of sperm to egg plasma membrane (GO:0007342)2.68018353
95negative regulation of alpha-beta T cell differentiation (GO:0046639)2.67916664
96positive regulation of systemic arterial blood pressure (GO:0003084)2.67853736
97regulation of coagulation (GO:0050818)2.65780605
98positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.64851706
99positive regulation of Rho protein signal transduction (GO:0035025)2.63136374
100relaxation of smooth muscle (GO:0044557)2.62842263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.16657651
2GBX2_23144817_ChIP-Seq_PC3_Human3.12268863
3SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.08850558
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.53568585
5GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.33055500
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.31339270
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27278729
8SCL_19346495_ChIP-Seq_HPC-7_Human2.15490394
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12634843
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09915243
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03998108
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.02012666
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00351480
14TAF15_26573619_Chip-Seq_HEK293_Human1.99964216
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97932531
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.94223161
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.90666136
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81014173
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.81014173
20TCF4_18268006_ChIP-ChIP_LS174T_Human1.77242557
21VDR_22108803_ChIP-Seq_LS180_Human1.76166814
22BCAT_22108803_ChIP-Seq_LS180_Human1.73507762
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66775990
24GATA1_19941826_ChIP-Seq_K562_Human1.66530756
25GATA2_19941826_ChIP-Seq_K562_Human1.64737966
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63309736
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61031122
28LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59370418
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56934087
30SMAD4_21799915_ChIP-Seq_A2780_Human1.56062586
31GATA1_19941827_ChIP-Seq_MEL_Mouse1.55900812
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55846267
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55631666
34RUNX_20019798_ChIP-Seq_JUKART_Human1.53217048
35PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.51846463
36GATA1_22025678_ChIP-Seq_K562_Human1.49879007
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47476365
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46907255
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45322998
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.41663109
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40513680
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40229046
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39801159
44STAT3_23295773_ChIP-Seq_U87_Human1.37298398
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37221509
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37221509
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36110407
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.35477811
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34830142
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.34555468
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.33400330
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.32901232
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.30156311
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30014510
55HTT_18923047_ChIP-ChIP_STHdh_Human1.29410645
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29161543
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26044090
58SPI1_23127762_ChIP-Seq_K562_Human1.25345533
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25242784
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24217939
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24101845
62TCF4_23295773_ChIP-Seq_U87_Human1.20419044
63SALL4_22934838_ChIP-ChIP_CD34+_Human1.20373237
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18214523
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16964844
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.14485787
67ER_23166858_ChIP-Seq_MCF-7_Human1.13896349
68AR_25329375_ChIP-Seq_VCAP_Human1.13743627
69P300_19829295_ChIP-Seq_ESCs_Human1.13038372
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12008644
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11989204
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11867897
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10726085
74LXR_22158963_ChIP-Seq_LIVER_Mouse1.09553863
75AR_21572438_ChIP-Seq_LNCaP_Human1.08977630
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06082059
77TP53_16413492_ChIP-PET_HCT116_Human1.05651013
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.04995629
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04811808
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.04773070
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03154676
82P53_22387025_ChIP-Seq_ESCs_Mouse1.02803249
83GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01755859
84CDX2_22108803_ChIP-Seq_LS180_Human1.01641601
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00785674
86IRF8_27001747_Chip-Seq_BMDM_Mouse1.00740602
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98537532
88SMRT_27268052_Chip-Seq_Bcells_Human0.98413652
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97799816
90CJUN_26792858_Chip-Seq_BT549_Human0.97333864
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96981380
92E2F1_18555785_Chip-Seq_ESCs_Mouse0.95798591
93OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95457478
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95244735
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94855385
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94822639
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93998671
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.93899131
99CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93732551
100TCF4_22108803_ChIP-Seq_LS180_Human0.93545734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.60800139
2MP0002638_abnormal_pupillary_reflex5.52033590
3MP0001661_extended_life_span4.87285435
4MP0008004_abnormal_stomach_pH3.47762640
5MP0004510_myositis3.07534297
6MP0003136_yellow_coat_color2.78731449
7MP0005275_abnormal_skin_tensile2.78613482
8MP0000579_abnormal_nail_morphology2.43337048
9MP0003011_delayed_dark_adaptation2.43257442
10MP0003724_increased_susceptibility_to2.30846363
11MP0002736_abnormal_nociception_after2.27499868
12MP0000013_abnormal_adipose_tissue2.12242284
13MP0006054_spinal_hemorrhage2.10388640
14MP0003950_abnormal_plasma_membrane1.91381888
15MP0004084_abnormal_cardiac_muscle1.90705471
16MP0000230_abnormal_systemic_arterial1.81881549
17MP0000465_gastrointestinal_hemorrhage1.80529860
18MP0001879_abnormal_lymphatic_vessel1.74844039
19MP0004036_abnormal_muscle_relaxation1.69402894
20MP0005171_absent_coat_pigmentation1.66455431
21MP0003329_amyloid_beta_deposits1.66005972
22MP0001502_abnormal_circadian_rhythm1.64013899
23MP0004130_abnormal_muscle_cell1.62215977
24MP0001851_eye_inflammation1.58554264
25MP0001835_abnormal_antigen_presentation1.58104106
26MP0000343_altered_response_to1.56615214
27MP0003638_abnormal_response/metabolism_1.56181789
28MP0005167_abnormal_blood-brain_barrier1.54945146
29MP0002132_abnormal_respiratory_system1.52498095
30MP0000383_abnormal_hair_follicle1.51931593
31MP0003566_abnormal_cell_adhesion1.50656314
32MP0004272_abnormal_basement_membrane1.48655823
33MP0010368_abnormal_lymphatic_system1.44991731
34MP0004215_abnormal_myocardial_fiber1.44691500
35MP0009053_abnormal_anal_canal1.42270231
36MP0001853_heart_inflammation1.41752359
37MP0003303_peritoneal_inflammation1.41577779
38MP0004947_skin_inflammation1.35887047
39MP0003828_pulmonary_edema1.34884041
40MP0000685_abnormal_immune_system1.31958896
41MP0001968_abnormal_touch/_nociception1.26828774
42MP0001790_abnormal_immune_system1.26106995
43MP0005387_immune_system_phenotype1.26106995
44MP0005551_abnormal_eye_electrophysiolog1.25096066
45MP0005365_abnormal_bile_salt1.24740019
46MP0008775_abnormal_heart_ventricle1.23812089
47MP0005058_abnormal_lysosome_morphology1.23578374
48MP0005671_abnormal_response_to1.23254931
49MP0010329_abnormal_lipoprotein_level1.20043346
50MP0005084_abnormal_gallbladder_morpholo1.08487900
51MP0005253_abnormal_eye_physiology1.08384024
52MP0009763_increased_sensitivity_to1.06527769
53MP0002138_abnormal_hepatobiliary_system1.01052055
54MP0005595_abnormal_vascular_smooth1.01004381
55MP0000249_abnormal_blood_vessel1.00013889
56MP0001800_abnormal_humoral_immune0.98654110
57MP0003646_muscle_fatigue0.97981590
58MP0005620_abnormal_muscle_contractility0.92078291
59MP0002972_abnormal_cardiac_muscle0.91554640
60MP0008872_abnormal_physiological_respon0.91346233
61MP0002733_abnormal_thermal_nociception0.90091036
62MP0003091_abnormal_cell_migration0.89698560
63MP0006276_abnormal_autonomic_nervous0.89008598
64MP0000604_amyloidosis0.88778545
65MP0003656_abnormal_erythrocyte_physiolo0.86739382
66MP0005000_abnormal_immune_tolerance0.85928602
67MP0000751_myopathy0.83084472
68MP0001664_abnormal_digestion0.81487820
69MP0005085_abnormal_gallbladder_physiolo0.78242484
70MP0008438_abnormal_cutaneous_collagen0.76903177
71MP0005023_abnormal_wound_healing0.76730096
72MP0002090_abnormal_vision0.75954305
73MP0005410_abnormal_fertilization0.73289544
74MP0002128_abnormal_blood_circulation0.73246213
75MP0003879_abnormal_hair_cell0.72690518
76MP0003252_abnormal_bile_duct0.72338478
77MP0008569_lethality_at_weaning0.71121777
78MP0003045_fibrosis0.70003826
79MP0002095_abnormal_skin_pigmentation0.67856572
80MP0010155_abnormal_intestine_physiology0.66641320
81MP0002398_abnormal_bone_marrow0.66511448
82MP0008874_decreased_physiological_sensi0.66203258
83MP0002234_abnormal_pharynx_morphology0.65991339
84MP0000749_muscle_degeneration0.65658844
85MP0010678_abnormal_skin_adnexa0.64355563
86MP0005646_abnormal_pituitary_gland0.63651552
87MP0002452_abnormal_antigen_presenting0.63155656
88MP0001545_abnormal_hematopoietic_system0.62935972
89MP0005397_hematopoietic_system_phenotyp0.62935972
90MP0005165_increased_susceptibility_to0.62919745
91MP0009642_abnormal_blood_homeostasis0.62870201
92MP0001663_abnormal_digestive_system0.61721194
93MP0004484_altered_response_of0.61614491
94MP0005670_abnormal_white_adipose0.60908930
95MP0002723_abnormal_immune_serum0.60477264
96MP0002118_abnormal_lipid_homeostasis0.60143050
97MP0001756_abnormal_urination0.59150065
98MP0002089_abnormal_postnatal_growth/wei0.58495213
99MP0002909_abnormal_adrenal_gland0.58448763
100MP0001970_abnormal_pain_threshold0.57840032

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)8.32743332
2Menorrhagia (HP:0000132)7.48698013
3Petechiae (HP:0000967)7.30823200
4Conjunctival telangiectasia (HP:0000524)6.80030723
5Increased mean platelet volume (HP:0011877)6.66324288
6Purpura (HP:0000979)6.59167885
7Abnormal platelet volume (HP:0011876)6.15934670
8Epistaxis (HP:0000421)5.77094113
9Abnormality of the vasculature of the conjunctiva (HP:0008054)5.64911094
10Gingival bleeding (HP:0000225)5.28000267
11Hyperlipoproteinemia (HP:0010980)4.93754182
12Abnormality of binocular vision (HP:0011514)4.23041190
13Diplopia (HP:0000651)4.23041190
14Absent phalangeal crease (HP:0006109)4.02216424
15Impaired platelet aggregation (HP:0003540)4.01960276
16Abnormal platelet function (HP:0011869)4.01960276
17Follicular hyperkeratosis (HP:0007502)3.81885960
18Abnormal finger flexion creases (HP:0006143)3.52591857
19Spontaneous hematomas (HP:0007420)3.50070536
20Congenital, generalized hypertrichosis (HP:0004540)3.37991270
21Mitral stenosis (HP:0001718)3.28388926
22Coronal craniosynostosis (HP:0004440)3.24391373
23Abnormality of the common coagulation pathway (HP:0010990)3.17582191
24Pili torti (HP:0003777)2.93568336
25Poikilocytosis (HP:0004447)2.85794569
26Mucosal telangiectasiae (HP:0100579)2.83089384
27Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.77932070
28Neonatal respiratory distress (HP:0002643)2.75499144
29Abnormal pupillary function (HP:0007686)2.71390815
30Short 5th finger (HP:0009237)2.70994255
31Thyroid-stimulating hormone excess (HP:0002925)2.65516460
32Joint hemorrhage (HP:0005261)2.61846546
33Bruising susceptibility (HP:0000978)2.60320895
34Spontaneous abortion (HP:0005268)2.58534951
35Bundle branch block (HP:0011710)2.56797523
36Acanthocytosis (HP:0001927)2.47310991
37Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.43260671
38Polyphagia (HP:0002591)2.40075472
39Xanthomatosis (HP:0000991)2.38122207
40Papillary thyroid carcinoma (HP:0002895)2.37508916
41Abnormal hair laboratory examination (HP:0003328)2.37446014
42Paralysis (HP:0003470)2.37272217
43Exercise-induced myalgia (HP:0003738)2.35224118
44Atonic seizures (HP:0010819)2.33456252
45Joint swelling (HP:0001386)2.32743775
46Muscle fiber splitting (HP:0003555)2.21799751
47Supernumerary nipples (HP:0002558)2.19790281
48Broad foot (HP:0001769)2.19402059
49Abnormality of lateral ventricle (HP:0030047)2.14858503
50Menstrual irregularities (HP:0000858)2.11116512
51Abnormal auditory evoked potentials (HP:0006958)2.10909824
52Increased density of long bones (HP:0006392)2.10276862
53Growth hormone excess (HP:0000845)2.07965148
54Abnormality of the anterior chamber (HP:0000593)2.07166261
55Basal ganglia calcification (HP:0002135)2.05196540
56Neuroendocrine neoplasm (HP:0100634)2.05109923
57Blue irides (HP:0000635)2.01546321
58Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.98076654
59Status epilepticus (HP:0002133)1.93819941
60Generalized tonic-clonic seizures (HP:0002069)1.93170281
61Dyschromatopsia (HP:0007641)1.91369958
62Split foot (HP:0001839)1.90153065
63Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.82928177
64Hemiparesis (HP:0001269)1.81444544
65Neoplasm of the heart (HP:0100544)1.80475122
66Nemaline bodies (HP:0003798)1.80091241
67Woolly hair (HP:0002224)1.78967086
68Pheochromocytoma (HP:0002666)1.77262003
69Spastic paraparesis (HP:0002313)1.76896535
70Upper limb muscle weakness (HP:0003484)1.76849338
71Abnormality of calcium-phosphate metabolism (HP:0100530)1.76750106
72Abolished electroretinogram (ERG) (HP:0000550)1.76578628
73Decreased central vision (HP:0007663)1.75513193
74Vascular calcification (HP:0004934)1.75491351
75Hyperpituitarism (HP:0010514)1.73920095
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73457379
77Postural tremor (HP:0002174)1.73353491
78Testicular neoplasm (HP:0010788)1.72223401
79Increased cerebral lipofuscin (HP:0011813)1.71733211
80Wide anterior fontanel (HP:0000260)1.71708406
81Increased neuronal autofluorescent lipopigment (HP:0002074)1.70943988
82Hypoplasia of the iris (HP:0007676)1.70014234
83Conjugated hyperbilirubinemia (HP:0002908)1.68828020
84Increased variability in muscle fiber diameter (HP:0003557)1.64248958
85Cardiovascular calcification (HP:0011915)1.63261313
86Striae distensae (HP:0001065)1.62083860
87Focal seizures (HP:0007359)1.61410541
88Ventricular fibrillation (HP:0001663)1.60728362
89Generalized myoclonic seizures (HP:0002123)1.60311693
90Hypercortisolism (HP:0001578)1.59172134
91Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.58264710
92Insidious onset (HP:0003587)1.56743050
93Termporal pattern (HP:0011008)1.56743050
94Abnormality of skeletal muscle fiber size (HP:0012084)1.55417799
95Vertigo (HP:0002321)1.52658595
96Hepatosplenomegaly (HP:0001433)1.52054424
97Gait imbalance (HP:0002141)1.51856131
98Muscle fiber inclusion bodies (HP:0100299)1.51370250
99Intellectual disability, mild (HP:0001256)1.50211698
100Biliary tract neoplasm (HP:0100574)1.49189533

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK3.31420351
2PDK23.21461935
3RIPK42.96985759
4MST42.93086527
5BMX2.88473371
6PTK2B2.78651748
7STK38L2.74915979
8PIK3CG2.71834476
9MAP4K22.66973181
10FGR2.52921230
11STK242.23728568
12OBSCN2.20521794
13TEC2.19283362
14CSF1R2.09526330
15MKNK22.02937654
16FRK1.99782695
17BTK1.97359297
18STK31.83384928
19SYK1.79259716
20PHKG11.75202948
21PHKG21.75202948
22MAPKAPK31.66779186
23TRPM71.58466334
24PLK21.57319698
25CSK1.56866239
26EIF2AK11.54414041
27BMPR1B1.40138044
28EPHA31.36173937
29BLK1.35955084
30BMPR21.34522814
31GRK51.32046642
32JAK31.27417242
33DYRK1A1.27248036
34MAPK121.26917628
35FER1.13998444
36NEK91.11467253
37TIE11.09154622
38ZAP701.06610393
39ILK1.05273981
40GRK11.04309718
41EPHB21.03443844
42IKBKB0.99952594
43TAOK30.96243331
44PAK30.92297846
45LYN0.91634432
46PKN10.89798191
47MARK30.89345731
48ADRBK20.89306081
49HCK0.80262678
50FES0.79578269
51MAPK70.79026901
52LMTK20.77373931
53MKNK10.75635960
54JAK10.74724586
55TNIK0.73919336
56DDR20.72863861
57PDK10.71393789
58ITK0.70675170
59NLK0.70351661
60TLK10.69282077
61TNK20.67404455
62SIK10.66909196
63PRKACG0.65191506
64IRAK10.64521505
65MAP3K120.64019185
66GRK60.63636262
67PDGFRB0.62070423
68DAPK30.61869422
69ADRBK10.59543948
70MAP3K50.59450357
71MAPK130.57460601
72PRKG10.57320052
73ROCK10.57072038
74PDPK10.52214215
75TXK0.52078809
76PRKCE0.51949019
77SGK20.51040238
78IRAK20.49473330
79IGF1R0.48928651
80PRKD10.48910767
81BRSK20.47557866
82ABL20.47515179
83DAPK20.45040879
84ABL10.41705157
85GSK3A0.40201943
86RET0.39817576
87CCNB10.39603209
88PRKACA0.39323847
89MAP3K100.38795158
90PIM20.36638550
91PAK10.36420977
92VRK10.35932983
93CAMK2A0.35415537
94SIK30.35255043
95PRKACB0.34664800
96MAPKAPK20.31694939
97MAP2K10.31502079
98PRKCZ0.30400270
99FYN0.30017006
100PRKCA0.29969304

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046113.84976646
2beta-Alanine metabolism_Homo sapiens_hsa004103.24739971
3Glycerolipid metabolism_Homo sapiens_hsa005613.10787625
4ABC transporters_Homo sapiens_hsa020103.04149264
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.67291351
6One carbon pool by folate_Homo sapiens_hsa006702.52897833
7ECM-receptor interaction_Homo sapiens_hsa045122.46463725
8Histidine metabolism_Homo sapiens_hsa003402.45310081
9Complement and coagulation cascades_Homo sapiens_hsa046102.37221218
10Nitrogen metabolism_Homo sapiens_hsa009102.27304619
11Staphylococcus aureus infection_Homo sapiens_hsa051501.83629195
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83046059
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.77246400
14Renin-angiotensin system_Homo sapiens_hsa046141.76288615
15Arachidonic acid metabolism_Homo sapiens_hsa005901.57592984
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.56123769
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.54329452
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.54190171
19Hematopoietic cell lineage_Homo sapiens_hsa046401.48236288
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.44114894
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.41151804
22Arginine and proline metabolism_Homo sapiens_hsa003301.35556250
23Circadian rhythm_Homo sapiens_hsa047101.35466754
24Fatty acid degradation_Homo sapiens_hsa000711.33157781
25Choline metabolism in cancer_Homo sapiens_hsa052311.29918431
26Asthma_Homo sapiens_hsa053101.28859806
27Phospholipase D signaling pathway_Homo sapiens_hsa040721.28352039
28Tryptophan metabolism_Homo sapiens_hsa003801.25935042
29Olfactory transduction_Homo sapiens_hsa047401.25825802
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.23201224
31Linoleic acid metabolism_Homo sapiens_hsa005911.22024798
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21671120
33Dilated cardiomyopathy_Homo sapiens_hsa054141.13752187
34Chemical carcinogenesis_Homo sapiens_hsa052041.11200251
35Serotonergic synapse_Homo sapiens_hsa047261.09749554
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08600710
37Lysine degradation_Homo sapiens_hsa003101.07399390
38Pancreatic secretion_Homo sapiens_hsa049721.06341865
39Retinol metabolism_Homo sapiens_hsa008301.00659473
40Gap junction_Homo sapiens_hsa045400.96668552
41Chemokine signaling pathway_Homo sapiens_hsa040620.96112472
42Bile secretion_Homo sapiens_hsa049760.94770810
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92512934
44Systemic lupus erythematosus_Homo sapiens_hsa053220.89490906
45Fatty acid elongation_Homo sapiens_hsa000620.89484835
46PPAR signaling pathway_Homo sapiens_hsa033200.88663276
47Focal adhesion_Homo sapiens_hsa045100.85520664
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84117282
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82996153
50Collecting duct acid secretion_Homo sapiens_hsa049660.81583059
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80787499
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.80692413
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79096227
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78465498
55Calcium signaling pathway_Homo sapiens_hsa040200.78057782
56Malaria_Homo sapiens_hsa051440.77218697
57Glutathione metabolism_Homo sapiens_hsa004800.72703618
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71850633
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68930174
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62793618
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59114314
62GABAergic synapse_Homo sapiens_hsa047270.59049837
63Amoebiasis_Homo sapiens_hsa051460.57610185
64B cell receptor signaling pathway_Homo sapiens_hsa046620.56568112
65Endocytosis_Homo sapiens_hsa041440.56412748
66Starch and sucrose metabolism_Homo sapiens_hsa005000.56245453
67Sulfur metabolism_Homo sapiens_hsa009200.55868056
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54225460
69Insulin resistance_Homo sapiens_hsa049310.53189602
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52395135
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.52278872
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51681453
73Circadian entrainment_Homo sapiens_hsa047130.48635904
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.46941408
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46738773
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45975837
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45188452
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44727146
79Salivary secretion_Homo sapiens_hsa049700.43832959
80Glutamatergic synapse_Homo sapiens_hsa047240.43627229
81cAMP signaling pathway_Homo sapiens_hsa040240.42583322
82Fatty acid biosynthesis_Homo sapiens_hsa000610.40782161
83Phagosome_Homo sapiens_hsa041450.39995834
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39442215
85Oxytocin signaling pathway_Homo sapiens_hsa049210.38944300
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38607833
87Long-term depression_Homo sapiens_hsa047300.36973967
88Rap1 signaling pathway_Homo sapiens_hsa040150.36896234
89Peroxisome_Homo sapiens_hsa041460.36701127
90Gastric acid secretion_Homo sapiens_hsa049710.35759037
91Alcoholism_Homo sapiens_hsa050340.35614269
92Graft-versus-host disease_Homo sapiens_hsa053320.34457696
93Morphine addiction_Homo sapiens_hsa050320.32450076
94Small cell lung cancer_Homo sapiens_hsa052220.32079307
95Ovarian steroidogenesis_Homo sapiens_hsa049130.31851125
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.30280082
97Glucagon signaling pathway_Homo sapiens_hsa049220.28015365
98Viral myocarditis_Homo sapiens_hsa054160.27678948
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27598471
100Hedgehog signaling pathway_Homo sapiens_hsa043400.26832192

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