LOC440461

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)5.09391119
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.94662667
3negative regulation of cell killing (GO:0031342)4.94662667
4cellular extravasation (GO:0045123)4.71738156
5neutrophil activation involved in immune response (GO:0002283)4.57057981
6NIK/NF-kappaB signaling (GO:0038061)4.56020769
7response to muramyl dipeptide (GO:0032495)4.17327627
8regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.01759964
9negative regulation of interleukin-12 production (GO:0032695)3.98892744
10regulation of chemokine biosynthetic process (GO:0045073)3.86345178
11germinal center formation (GO:0002467)3.78200009
12macrophage activation involved in immune response (GO:0002281)3.74056840
13positive regulation of gamma-delta T cell activation (GO:0046645)3.68209345
14positive regulation by symbiont of host defense response (GO:0052509)3.62982781
15modulation by symbiont of host defense response (GO:0052031)3.62982781
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.62982781
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.62982781
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.62982781
19modulation by symbiont of host immune response (GO:0052553)3.62982781
20defense response to protozoan (GO:0042832)3.59341644
21immunoglobulin mediated immune response (GO:0016064)3.56390133
22leukocyte aggregation (GO:0070486)3.51112219
23positive regulation of chemokine biosynthetic process (GO:0045080)3.46577334
24regulation of mast cell degranulation (GO:0043304)3.40458556
25negative regulation of erythrocyte differentiation (GO:0045647)3.40220998
26regulation of interferon-beta biosynthetic process (GO:0045357)3.38050225
27response to protozoan (GO:0001562)3.34400623
28lipopolysaccharide-mediated signaling pathway (GO:0031663)3.27350231
29regulation of leukocyte degranulation (GO:0043300)3.21308888
30negative regulation of phagocytosis (GO:0050765)3.19726984
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.17233977
32granulocyte activation (GO:0036230)3.13197946
33microglial cell activation (GO:0001774)3.12663696
34regulation of myeloid leukocyte mediated immunity (GO:0002886)3.09855685
35tumor necrosis factor-mediated signaling pathway (GO:0033209)3.07813383
36regulation of B cell receptor signaling pathway (GO:0050855)3.06193414
37macrophage activation (GO:0042116)3.05363449
38regulation of mast cell activation involved in immune response (GO:0033006)3.04205110
39antigen processing and presentation of endogenous antigen (GO:0019883)3.02196228
40detection of bacterium (GO:0016045)3.00499825
41detection of other organism (GO:0098543)2.98925815
42myeloid cell activation involved in immune response (GO:0002275)2.98348741
43neutrophil activation (GO:0042119)2.97136965
44mannose metabolic process (GO:0006013)2.94686487
45negative regulation of innate immune response (GO:0045824)2.94575132
46positive regulation of mast cell activation involved in immune response (GO:0033008)2.94262252
47positive regulation of mast cell degranulation (GO:0043306)2.94262252
48positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93715225
49cellular response to type I interferon (GO:0071357)2.91811326
50type I interferon signaling pathway (GO:0060337)2.91811326
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91445928
52response to type I interferon (GO:0034340)2.91168227
53neutrophil mediated immunity (GO:0002446)2.91061136
54respiratory burst (GO:0045730)2.90960761
55negative regulation of cytokine production involved in immune response (GO:0002719)2.90539932
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.90367893
57positive regulation of heat generation (GO:0031652)2.89155411
58CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.88493780
59T-helper cell differentiation (GO:0042093)2.88493780
60activation of MAPKKK activity (GO:0000185)2.86162869
61positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.83197789
62induction of positive chemotaxis (GO:0050930)2.83079430
63negative regulation of growth of symbiont in host (GO:0044130)2.82784936
64negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.82784936
65modulation of growth of symbiont involved in interaction with host (GO:0044144)2.82784936
66regulation of growth of symbiont in host (GO:0044126)2.82784936
67regulation of type I interferon-mediated signaling pathway (GO:0060338)2.82549827
68regulation of T-helper 2 cell differentiation (GO:0045628)2.82391399
69regulation of vitamin D biosynthetic process (GO:0060556)2.81636223
70negative regulation of interleukin-6 production (GO:0032715)2.79819625
71regulation of gamma-delta T cell activation (GO:0046643)2.72054963
72negative regulation of myeloid cell apoptotic process (GO:0033033)2.71873540
73positive regulation of mast cell activation (GO:0033005)2.71665906
74positive regulation of tumor necrosis factor production (GO:0032760)2.70087704
75negative regulation of lymphocyte mediated immunity (GO:0002707)2.70034267
76eosinophil chemotaxis (GO:0048245)2.67703637
77myeloid dendritic cell differentiation (GO:0043011)2.67400980
78negative regulation of leukocyte mediated immunity (GO:0002704)2.67359481
79protein localization to endosome (GO:0036010)2.64684140
80regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.63269287
81positive regulation of leukocyte degranulation (GO:0043302)2.63071911
82regulation of interleukin-2 biosynthetic process (GO:0045076)2.62624682
83regulation of regulated secretory pathway (GO:1903305)2.62424736
84B cell mediated immunity (GO:0019724)2.58931653
85interferon-gamma-mediated signaling pathway (GO:0060333)2.58399493
86regulation of interferon-alpha production (GO:0032647)2.57537835
87positive thymic T cell selection (GO:0045059)2.57201663
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.57147934
89glycosphingolipid catabolic process (GO:0046479)2.55648089
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.55512391
91regulation of tumor necrosis factor production (GO:0032680)2.55260186
92myeloid dendritic cell activation (GO:0001773)2.51285154
93positive regulation of antigen processing and presentation (GO:0002579)2.51033285
94regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.50656045
95regulation of natural killer cell mediated immunity (GO:0002715)2.50656045
96regulation of mast cell activation (GO:0033003)2.50645175
97regulation of fever generation (GO:0031620)2.50056648
98modulation by symbiont of host cellular process (GO:0044068)2.46896031
99T cell migration (GO:0072678)2.46109503
100positive regulation of Cdc42 GTPase activity (GO:0043089)2.45857042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.65370453
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.20880012
3MYC_22102868_ChIP-Seq_BL_Human2.87233055
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.74888784
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.66374422
6VDR_24763502_ChIP-Seq_THP-1_Human2.57816069
7* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.55129585
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.53792536
9LXR_22292898_ChIP-Seq_THP-1_Human2.51079881
10* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.45155487
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.34480949
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34097590
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.31726333
14* KDM2B_26808549_Chip-Seq_DND41_Human2.25877475
15TCF7_22412390_ChIP-Seq_EML_Mouse2.22340595
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20382178
17MAF_26560356_Chip-Seq_TH1_Human2.18320258
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.17538144
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16227943
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15293040
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10302268
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09616658
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07142934
24UTX_26944678_Chip-Seq_JUKART_Human2.03499848
25RUNX1_22412390_ChIP-Seq_EML_Mouse1.98227245
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.98055546
27MAF_26560356_Chip-Seq_TH2_Human1.90725152
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89047110
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88334186
30SCL_19346495_ChIP-Seq_HPC-7_Human1.87997413
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86808564
32SPI1_23547873_ChIP-Seq_NB4_Human1.83901596
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83644644
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81919697
35* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78337636
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77971039
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77717395
38SPI1_23127762_ChIP-Seq_K562_Human1.77231727
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73306797
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71431109
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.70145898
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65721036
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59338388
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.53426150
45P68_20966046_ChIP-Seq_HELA_Human1.53357068
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.49222626
47PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.49049411
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48342106
49* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46228547
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42891540
51* KDM2B_26808549_Chip-Seq_JURKAT_Human1.42785840
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41858065
53* SA1_27219007_Chip-Seq_ERYTHROID_Human1.40069528
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39419336
55MYB_26560356_Chip-Seq_TH2_Human1.38943242
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37594910
57BCL6_27268052_Chip-Seq_Bcells_Human1.37015051
58* MYB_26560356_Chip-Seq_TH1_Human1.34586330
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34246204
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33845226
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.33785763
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33386399
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.32354847
64SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29303533
65* KDM2B_26808549_Chip-Seq_K562_Human1.29014793
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.29011218
67RUNX_20019798_ChIP-Seq_JUKART_Human1.28748452
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28554656
69BCOR_27268052_Chip-Seq_Bcells_Human1.26423027
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26331012
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.25704463
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25637202
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25545369
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25493857
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24585295
76SMC4_20622854_ChIP-Seq_HELA_Human1.23230463
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22546725
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19869555
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16424553
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15157239
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15028091
82NCOR1_26117541_ChIP-Seq_K562_Human1.14758367
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13993286
84CTCF_26484167_Chip-Seq_Bcells_Mouse1.13579719
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13430967
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12935877
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12649489
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11101952
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09506392
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09111505
91CREB1_26743006_Chip-Seq_LNCaP_Human1.07940436
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06510217
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06027533
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05390958
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04457070
96* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03788491
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02465649
98TFEB_21752829_ChIP-Seq_HELA_Human1.02077854
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99970900
100ZNF263_19887448_ChIP-Seq_K562_Human0.97497077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.05017298
2MP0005058_abnormal_lysosome_morphology3.86496103
3MP0003436_decreased_susceptibility_to3.78651562
4MP0004510_myositis2.87086148
5MP0001835_abnormal_antigen_presentation2.83521916
6MP0009278_abnormal_bone_marrow2.76108323
7MP0005000_abnormal_immune_tolerance2.66322000
8MP0002419_abnormal_innate_immunity2.63238098
9MP0006082_CNS_inflammation2.62779989
10MP0005025_abnormal_response_to2.58255165
11MP0003724_increased_susceptibility_to2.55693375
12MP0002148_abnormal_hypersensitivity_rea2.51400164
13MP0009785_altered_susceptibility_to2.50746979
14MP0005387_immune_system_phenotype2.49125660
15MP0001790_abnormal_immune_system2.49125660
16MP0003191_abnormal_cellular_cholesterol2.34403436
17MP0000685_abnormal_immune_system2.33198376
18MP0001800_abnormal_humoral_immune2.32007966
19MP0005671_abnormal_response_to2.31961647
20MP0002723_abnormal_immune_serum2.25732573
21MP0002452_abnormal_antigen_presenting2.19790503
22MP0003172_abnormal_lysosome_physiology2.18880695
23MP0003763_abnormal_thymus_physiology2.16850366
24MP0002420_abnormal_adaptive_immunity2.11804922
25MP0001819_abnormal_immune_cell2.10350808
26MP0004947_skin_inflammation2.08242881
27MP0003300_gastrointestinal_ulcer2.00596212
28MP0010155_abnormal_intestine_physiology1.91455247
29MP0001533_abnormal_skeleton_physiology1.88886397
30MP0005451_abnormal_body_composition1.87429983
31MP0005310_abnormal_salivary_gland1.86485192
32MP0001873_stomach_inflammation1.85848590
33MP0002254_reproductive_system_inflammat1.79710273
34MP0002405_respiratory_system_inflammati1.77865652
35MP0009840_abnormal_foam_cell1.72523894
36MP0000858_altered_metastatic_potential1.68646111
37MP0009333_abnormal_splenocyte_physiolog1.67364463
38MP0001845_abnormal_inflammatory_respons1.65681405
39MP0003453_abnormal_keratinocyte_physiol1.64385823
40MP0000716_abnormal_immune_system1.62080281
41MP0002398_abnormal_bone_marrow1.60989249
42MP0005397_hematopoietic_system_phenotyp1.58827268
43MP0001545_abnormal_hematopoietic_system1.58827268
44MP0003705_abnormal_hypodermis_morpholog1.57873589
45MP0001853_heart_inflammation1.55298123
46MP0005464_abnormal_platelet_physiology1.54375909
47MP0004185_abnormal_adipocyte_glucose1.49565341
48MP0009764_decreased_sensitivity_to1.39669380
49MP0008469_abnormal_protein_level1.38831713
50MP0003075_altered_response_to1.37381673
51MP0002998_abnormal_bone_remodeling1.36535586
52MP0003183_abnormal_peptide_metabolism1.30274611
53MP0002722_abnormal_immune_system1.29716671
54MP0002429_abnormal_blood_cell1.28685431
55MP0003279_aneurysm1.27130083
56MP0000343_altered_response_to1.24529269
57MP0000490_abnormal_crypts_of1.24113514
58MP0000689_abnormal_spleen_morphology1.23493975
59MP0008260_abnormal_autophagy1.22614539
60MP0000703_abnormal_thymus_morphology1.22565820
61MP0005076_abnormal_cell_differentiation1.19504835
62MP0000465_gastrointestinal_hemorrhage1.18189174
63MP0004381_abnormal_hair_follicle1.12450697
64MP0005666_abnormal_adipose_tissue1.09859873
65MP0000604_amyloidosis0.98884925
66MP0003866_abnormal_defecation0.98681335
67MP0005167_abnormal_blood-brain_barrier0.95849877
68MP0002332_abnormal_exercise_endurance0.93730518
69MP0002796_impaired_skin_barrier0.91568623
70MP0003448_altered_tumor_morphology0.90479106
71MP0001663_abnormal_digestive_system0.88699254
72MP0005075_abnormal_melanosome_morpholog0.86998619
73MP0003828_pulmonary_edema0.83055929
74MP0004808_abnormal_hematopoietic_stem0.82979049
75MP0005166_decreased_susceptibility_to0.81686230
76MP0005164_abnormal_response_to0.79226796
77MP0002877_abnormal_melanocyte_morpholog0.79038041
78MP0000767_abnormal_smooth_muscle0.77549906
79MP0005501_abnormal_skin_physiology0.76269062
80MP0005390_skeleton_phenotype0.75529082
81MP0002933_joint_inflammation0.73620953
82MP0009763_increased_sensitivity_to0.73321165
83MP0003795_abnormal_bone_structure0.71495977
84MP0000249_abnormal_blood_vessel0.71475725
85MP0004883_abnormal_blood_vessel0.71075106
86MP0005375_adipose_tissue_phenotype0.70955884
87MP0001851_eye_inflammation0.70110105
88MP0008004_abnormal_stomach_pH0.69894123
89MP0010307_abnormal_tumor_latency0.69636097
90MP0001986_abnormal_taste_sensitivity0.69156536
91MP0008874_decreased_physiological_sensi0.67434090
92MP0006054_spinal_hemorrhage0.66994280
93MP0000371_diluted_coat_color0.64548160
94MP0001849_ear_inflammation0.63884592
95MP0003091_abnormal_cell_migration0.63217497
96MP0010234_abnormal_vibrissa_follicle0.62953581
97MP0000015_abnormal_ear_pigmentation0.62795487
98MP0001216_abnormal_epidermal_layer0.59961519
99MP0003806_abnormal_nucleotide_metabolis0.59636214
100MP0001191_abnormal_skin_condition0.59326037

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.70756784
2Abnormality of liposaccharide metabolism (HP:0010968)5.70756784
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.70756784
4Eczematoid dermatitis (HP:0000976)4.35871147
5Dysostosis multiplex (HP:0000943)4.24188781
6Recurrent bacterial skin infections (HP:0005406)4.13091102
7Recurrent abscess formation (HP:0002722)4.07620334
8Abnormality of macrophages (HP:0004311)3.99836739
9Mediastinal lymphadenopathy (HP:0100721)3.59387807
10Abnormality of mucopolysaccharide metabolism (HP:0011020)3.59189000
11Abnormality of polysaccharide metabolism (HP:0011012)3.59189000
12Abnormality of glycosaminoglycan metabolism (HP:0004371)3.59189000
13Thin bony cortex (HP:0002753)3.33980549
14Chronic obstructive pulmonary disease (HP:0006510)3.32182618
15Obstructive lung disease (HP:0006536)3.32182618
16Stomatitis (HP:0010280)3.23379042
17Loss of speech (HP:0002371)3.18623463
18Meningitis (HP:0001287)3.14404748
19Increased cerebral lipofuscin (HP:0011813)3.11966457
20Elevated erythrocyte sedimentation rate (HP:0003565)3.07004660
21Urinary glycosaminoglycan excretion (HP:0003541)3.03132388
22Mucopolysacchariduria (HP:0008155)3.03132388
23Chronic mucocutaneous candidiasis (HP:0002728)3.02151938
24Recurrent cutaneous fungal infections (HP:0011370)3.02151938
25Myositis (HP:0100614)2.99027248
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.98388643
27Systemic lupus erythematosus (HP:0002725)2.95445447
28Vacuolated lymphocytes (HP:0001922)2.88795514
29Recurrent skin infections (HP:0001581)2.85113013
30Orchitis (HP:0100796)2.80690662
31Increased serum ferritin (HP:0003281)2.79378309
32Increased IgE level (HP:0003212)2.78552715
33Disinhibition (HP:0000734)2.78066884
34Vasculitis (HP:0002633)2.77753990
35Recurrent fungal infections (HP:0002841)2.77065731
36Hepatosplenomegaly (HP:0001433)2.76580262
37Spontaneous hematomas (HP:0007420)2.70300965
38Recurrent gram-negative bacterial infections (HP:0005420)2.69680629
39Cellulitis (HP:0100658)2.69558608
40Hemoptysis (HP:0002105)2.63598903
41Gastrointestinal infarctions (HP:0005244)2.54350509
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.54123006
43Chest pain (HP:0100749)2.50007353
44Optic neuritis (HP:0100653)2.49883439
45Retrobulbar optic neuritis (HP:0100654)2.49883439
46Petechiae (HP:0000967)2.47802731
47Apathy (HP:0000741)2.46505970
48Purpura (HP:0000979)2.45464074
49Gingivitis (HP:0000230)2.44671965
50Diminished motivation (HP:0000745)2.44037955
51Progressive neurologic deterioration (HP:0002344)2.42324340
52Axonal loss (HP:0003447)2.42181108
53Colitis (HP:0002583)2.33629751
54Pulmonary infiltrates (HP:0002113)2.33534095
55Neuronal loss in central nervous system (HP:0002529)2.23227882
56Autoimmune thrombocytopenia (HP:0001973)2.22101297
57Urticaria (HP:0001025)2.20397678
58Gastrointestinal inflammation (HP:0004386)2.19078237
59Pustule (HP:0200039)2.16836472
60Asymmetric septal hypertrophy (HP:0001670)2.15325146
61Agammaglobulinemia (HP:0004432)2.14715856
62Restrictive lung disease (HP:0002091)2.14038617
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.13615474
64Amyloidosis (HP:0011034)2.11242877
65Inflammation of the large intestine (HP:0002037)2.11130142
66Gastrointestinal stroma tumor (HP:0100723)2.10566285
67Bone pain (HP:0002653)2.09664850
68Basal ganglia calcification (HP:0002135)2.09126745
69Recurrent viral infections (HP:0004429)2.08431650
70J-shaped sella turcica (HP:0002680)2.08369512
71Gangrene (HP:0100758)2.08046541
72Mutism (HP:0002300)2.06696030
73Abnormality of iron homeostasis (HP:0011031)2.04948795
74Pulmonary embolism (HP:0002204)2.04008402
75Interstitial pulmonary disease (HP:0006530)2.03725553
76Granulocytopenia (HP:0001913)2.02753009
77Hypergammaglobulinemia (HP:0010702)2.00768280
78Hematochezia (HP:0002573)1.98239757
79Epistaxis (HP:0000421)1.96909709
80Upper motor neuron abnormality (HP:0002127)1.95907058
81Abnormality of the pleura (HP:0002103)1.94404569
82Personality changes (HP:0000751)1.93933918
83Flat acetabular roof (HP:0003180)1.90743649
84Slow saccadic eye movements (HP:0000514)1.90593806
85Nuclear cataract (HP:0100018)1.90534137
86Osteomyelitis (HP:0002754)1.88173627
87Abnormality of the nasal mucosa (HP:0000433)1.88111635
88Metaphyseal irregularity (HP:0003025)1.86974049
89Sepsis (HP:0100806)1.82978760
90Keratoconjunctivitis sicca (HP:0001097)1.80742122
91Encephalitis (HP:0002383)1.80713043
92Episodic fever (HP:0001954)1.80088089
93Hemorrhage of the eye (HP:0011885)1.79716417
94Prolonged neonatal jaundice (HP:0006579)1.78588130
95Distal lower limb muscle weakness (HP:0009053)1.78225370
96Increased IgM level (HP:0003496)1.77928693
97Ragged-red muscle fibers (HP:0003200)1.77052045
98Pathologic fracture (HP:0002756)1.75323217
99Leukocytosis (HP:0001974)1.74908744
100Flat occiput (HP:0005469)1.73466192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.91893939
2TRIB33.55415933
3MAP4K13.38441363
4IRAK32.52231576
5IRAK42.47694762
6TBK12.35668177
7PRPF4B2.26522166
8MAP3K112.21545887
9RIPK42.20521121
10TAOK12.18791302
11MAP3K142.14738290
12MAP2K32.12562841
13CDK122.06793189
14TNK21.95665580
15SIK11.94201006
16BLK1.79714173
17TYK21.79695947
18IKBKE1.76086349
19NME21.67779355
20SMG11.66794820
21ZAP701.62257432
22TAOK21.58660972
23TESK21.58404130
24JAK31.48960044
25MAP3K31.45196103
26MAP3K131.44961840
27IKBKB1.43927687
28FES1.43480508
29MATK1.41636620
30CSK1.40142566
31PKN21.39214708
32RIPK11.33872827
33GRK61.29741575
34MAP3K101.28487943
35CDC42BPA1.25321383
36TGFBR21.24914748
37IRAK21.23951962
38SIK31.23523043
39CDK41.21656620
40FGR1.19912996
41MAP3K11.17782273
42CSF1R1.16876968
43BTK1.11889558
44TESK11.09134347
45SYK1.02861288
46HCK0.94784312
47MARK20.93988872
48ICK0.93864012
49GRK70.92517596
50LYN0.90471744
51EPHB10.90151005
52MARK30.89637562
53CDK60.87151013
54RPS6KL10.86198613
55RPS6KC10.86198613
56IRAK10.85677303
57SIK20.85020258
58PRKD20.84769760
59LCK0.84102957
60BMPR20.83208336
61CHUK0.82789207
62RPS6KA20.79553156
63TTN0.79317126
64RPS6KA60.73265289
65EPHA20.70598255
66HIPK20.69834170
67PDK10.69001147
68PTK60.67659768
69TXK0.66123516
70KIT0.65181467
71JAK20.64633410
72MAPKAPK30.63803565
73MAP3K60.63580956
74MOS0.62785196
75PDPK10.62775969
76KDR0.58438091
77STK380.57799133
78JAK10.56962705
79MAPKAPK20.56902187
80MAP3K80.56389932
81MAP2K20.54518161
82RPS6KB20.52823083
83PIM20.52806594
84MAP2K60.52375664
85CDK90.51577044
86KSR20.49127173
87LIMK10.48642140
88PAK40.47569120
89STK100.47098393
90BRD40.44576482
91EEF2K0.44536172
92RET0.43152386
93ITK0.42469770
94MAPK120.42153986
95PIK3CG0.41586473
96CAMKK10.40878078
97MAPK110.39019408
98RPS6KA40.38905891
99DDR20.37884534
100RPS6KA10.36305395

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.43125161
2Osteoclast differentiation_Homo sapiens_hsa043802.71221615
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.36788502
4Leishmaniasis_Homo sapiens_hsa051402.27532613
5Lysosome_Homo sapiens_hsa041422.15617297
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.11444207
7B cell receptor signaling pathway_Homo sapiens_hsa046622.11197280
8Acute myeloid leukemia_Homo sapiens_hsa052212.04296098
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.96595111
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.93823998
11Tuberculosis_Homo sapiens_hsa051521.92871119
12Staphylococcus aureus infection_Homo sapiens_hsa051501.89716840
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84413796
14Allograft rejection_Homo sapiens_hsa053301.83668153
15TNF signaling pathway_Homo sapiens_hsa046681.82427771
16Graft-versus-host disease_Homo sapiens_hsa053321.67775376
17Malaria_Homo sapiens_hsa051441.62578038
18Primary immunodeficiency_Homo sapiens_hsa053401.60551796
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55405213
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54122027
21Rheumatoid arthritis_Homo sapiens_hsa053231.51160287
22Type I diabetes mellitus_Homo sapiens_hsa049401.50624572
23Autoimmune thyroid disease_Homo sapiens_hsa053201.48956467
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47606428
25Pertussis_Homo sapiens_hsa051331.47519349
26Toxoplasmosis_Homo sapiens_hsa051451.46635360
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46562372
28Influenza A_Homo sapiens_hsa051641.46555409
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44128323
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39151406
31T cell receptor signaling pathway_Homo sapiens_hsa046601.37835700
32Hepatitis C_Homo sapiens_hsa051601.35277669
33Asthma_Homo sapiens_hsa053101.33094931
34VEGF signaling pathway_Homo sapiens_hsa043701.26663593
35Measles_Homo sapiens_hsa051621.24437126
36Hepatitis B_Homo sapiens_hsa051611.21253413
37Antigen processing and presentation_Homo sapiens_hsa046121.19717120
38Shigellosis_Homo sapiens_hsa051311.19256483
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.17075217
40Herpes simplex infection_Homo sapiens_hsa051681.14091615
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13957551
42Salmonella infection_Homo sapiens_hsa051321.13835311
43Chronic myeloid leukemia_Homo sapiens_hsa052201.12193836
44Legionellosis_Homo sapiens_hsa051341.12007217
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11777392
46Prion diseases_Homo sapiens_hsa050201.10718277
47Notch signaling pathway_Homo sapiens_hsa043301.09066364
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.06876826
49Hematopoietic cell lineage_Homo sapiens_hsa046401.05822597
50Viral myocarditis_Homo sapiens_hsa054161.05548005
51Apoptosis_Homo sapiens_hsa042101.05174640
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.02825769
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02121895
54Chemokine signaling pathway_Homo sapiens_hsa040621.00010037
55Prolactin signaling pathway_Homo sapiens_hsa049170.98904011
56Non-small cell lung cancer_Homo sapiens_hsa052230.98883327
57Phagosome_Homo sapiens_hsa041450.97730785
58African trypanosomiasis_Homo sapiens_hsa051430.97641992
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.96889092
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92282602
61Pancreatic cancer_Homo sapiens_hsa052120.91799437
62Bladder cancer_Homo sapiens_hsa052190.90449435
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.88238540
64mTOR signaling pathway_Homo sapiens_hsa041500.85700825
65Amoebiasis_Homo sapiens_hsa051460.83538260
66Epstein-Barr virus infection_Homo sapiens_hsa051690.81402994
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.79633877
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79257105
69Renal cell carcinoma_Homo sapiens_hsa052110.77882629
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70781496
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70499742
72Endocytosis_Homo sapiens_hsa041440.68818540
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68424677
74HTLV-I infection_Homo sapiens_hsa051660.66412122
75Insulin resistance_Homo sapiens_hsa049310.64051887
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.63412493
77Choline metabolism in cancer_Homo sapiens_hsa052310.60571247
78Viral carcinogenesis_Homo sapiens_hsa052030.59428268
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59274862
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57676035
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56639112
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55064430
83Prostate cancer_Homo sapiens_hsa052150.52331044
84GnRH signaling pathway_Homo sapiens_hsa049120.52282572
85Platelet activation_Homo sapiens_hsa046110.51617185
86ErbB signaling pathway_Homo sapiens_hsa040120.51094435
87Glioma_Homo sapiens_hsa052140.50265699
88FoxO signaling pathway_Homo sapiens_hsa040680.49618205
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49530404
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49372108
91Insulin signaling pathway_Homo sapiens_hsa049100.47929197
92Sphingolipid metabolism_Homo sapiens_hsa006000.46560422
93Collecting duct acid secretion_Homo sapiens_hsa049660.46528991
94MAPK signaling pathway_Homo sapiens_hsa040100.45734859
95Endometrial cancer_Homo sapiens_hsa052130.44418713
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43045581
97Vibrio cholerae infection_Homo sapiens_hsa051100.41474349
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39782951
99HIF-1 signaling pathway_Homo sapiens_hsa040660.39682701
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39615151

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