LONP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)5.38618285
2lysine catabolic process (GO:0006554)5.38618285
3proline biosynthetic process (GO:0006561)5.21454359
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.07853661
5L-phenylalanine metabolic process (GO:0006558)5.07853661
6DNA unwinding involved in DNA replication (GO:0006268)5.07096421
7L-phenylalanine catabolic process (GO:0006559)4.93548372
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.93548372
9glyoxylate metabolic process (GO:0046487)4.74811460
10Golgi transport vesicle coating (GO:0048200)4.72293080
11COPI coating of Golgi vesicle (GO:0048205)4.72293080
12alpha-linolenic acid metabolic process (GO:0036109)4.72155486
13glycine metabolic process (GO:0006544)4.70588167
14cysteine metabolic process (GO:0006534)4.62904501
15mitotic chromosome condensation (GO:0007076)4.55264569
162-oxoglutarate metabolic process (GO:0006103)4.48635053
17kynurenine metabolic process (GO:0070189)4.36460029
18serine family amino acid catabolic process (GO:0009071)4.33386525
19sulfur amino acid catabolic process (GO:0000098)4.27378269
20aromatic amino acid family catabolic process (GO:0009074)4.25890862
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.22794412
22serine family amino acid biosynthetic process (GO:0009070)4.19312612
23serine family amino acid metabolic process (GO:0009069)4.13621257
24negative regulation of fibrinolysis (GO:0051918)4.10300865
25homocysteine metabolic process (GO:0050667)4.07098060
26nuclear pore complex assembly (GO:0051292)4.04436939
27aspartate family amino acid catabolic process (GO:0009068)4.02844725
28amino-acid betaine metabolic process (GO:0006577)4.00450040
29urea cycle (GO:0000050)3.99377274
30urea metabolic process (GO:0019627)3.99377274
31negative regulation of fatty acid biosynthetic process (GO:0045717)3.95936189
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.92788442
33bile acid biosynthetic process (GO:0006699)3.85604291
34regulation of fatty acid beta-oxidation (GO:0031998)3.85362945
35spliceosomal tri-snRNP complex assembly (GO:0000244)3.85011581
36regulation of cholesterol homeostasis (GO:2000188)3.85010212
37valine metabolic process (GO:0006573)3.82928941
38regulation of mammary gland epithelial cell proliferation (GO:0033599)3.82863284
39acetyl-CoA metabolic process (GO:0006084)3.81922906
40positive regulation of fatty acid beta-oxidation (GO:0032000)3.80887836
41tricarboxylic acid metabolic process (GO:0072350)3.80625990
42folic acid-containing compound biosynthetic process (GO:0009396)3.80356568
434-hydroxyproline metabolic process (GO:0019471)3.75957049
44oxaloacetate metabolic process (GO:0006107)3.70162102
45tryptophan catabolic process (GO:0006569)3.70133348
46indole-containing compound catabolic process (GO:0042436)3.70133348
47indolalkylamine catabolic process (GO:0046218)3.70133348
48ethanol oxidation (GO:0006069)3.67155673
49proline metabolic process (GO:0006560)3.66227138
50fatty acid beta-oxidation (GO:0006635)3.65996957
51L-serine metabolic process (GO:0006563)3.65445121
52nitrogen cycle metabolic process (GO:0071941)3.65263711
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.64824923
54retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.64633584
55cellular protein complex localization (GO:0034629)3.61523883
56alpha-amino acid catabolic process (GO:1901606)3.60898602
57peptidyl-glutamic acid carboxylation (GO:0017187)3.58297088
58protein carboxylation (GO:0018214)3.58297088
59regulation of triglyceride catabolic process (GO:0010896)3.57251300
60regulation of early endosome to late endosome transport (GO:2000641)3.57210310
61protein retention in ER lumen (GO:0006621)3.57102800
62regulation of protein activation cascade (GO:2000257)3.56540416
63dicarboxylic acid biosynthetic process (GO:0043650)3.55895152
64cellular modified amino acid catabolic process (GO:0042219)3.54022532
65protein complex localization (GO:0031503)3.52173186
66complement activation, alternative pathway (GO:0006957)3.52140845
67tryptophan metabolic process (GO:0006568)3.51884986
68formation of translation preinitiation complex (GO:0001731)3.51747098
69negative regulation of cholesterol transport (GO:0032375)3.50422962
70negative regulation of sterol transport (GO:0032372)3.50422962
71regulation of fibrinolysis (GO:0051917)3.50178850
72low-density lipoprotein particle clearance (GO:0034383)3.48926361
73one-carbon metabolic process (GO:0006730)3.48075624
74high-density lipoprotein particle remodeling (GO:0034375)3.47173608
75plasma lipoprotein particle clearance (GO:0034381)3.46569954
76negative regulation of fatty acid metabolic process (GO:0045922)3.46052008
77adherens junction assembly (GO:0034333)3.46033032
78tetrahydrofolate metabolic process (GO:0046653)3.45395206
79fatty acid oxidation (GO:0019395)3.45047813
80fatty acid transmembrane transport (GO:1902001)3.42472089
81cellular amino acid catabolic process (GO:0009063)3.40720466
82triglyceride homeostasis (GO:0070328)3.40273344
83acylglycerol homeostasis (GO:0055090)3.40273344
84focal adhesion assembly (GO:0048041)3.36177323
85cell-substrate adherens junction assembly (GO:0007045)3.36177323
86regulation of complement activation (GO:0030449)3.35567964
87short-chain fatty acid metabolic process (GO:0046459)3.35314519
88lipid oxidation (GO:0034440)3.34744014
89carnitine metabolic process (GO:0009437)3.34177929
90cellular ketone body metabolic process (GO:0046950)3.34141982
91DNA replication initiation (GO:0006270)3.33331615
92glucose 6-phosphate metabolic process (GO:0051156)3.32779645
93tricarboxylic acid cycle (GO:0006099)3.32704949
94apoptotic process involved in morphogenesis (GO:0060561)3.32594113
95glutamate metabolic process (GO:0006536)3.32162994
96peptidyl-arginine omega-N-methylation (GO:0035247)3.31843867
97carnitine shuttle (GO:0006853)3.31545756
98negative regulation of cell size (GO:0045792)3.31395764
99nuclear pore organization (GO:0006999)3.31266195
100protein localization to endosome (GO:0036010)3.30581736
101regulation of fatty acid oxidation (GO:0046320)3.30002324
102aromatic amino acid family metabolic process (GO:0009072)3.26230722
103bile acid metabolic process (GO:0008206)3.25302893
104tyrosine metabolic process (GO:0006570)3.24995784
105fatty acid catabolic process (GO:0009062)3.20689980
106positive regulation of fatty acid oxidation (GO:0046321)3.20074505
107heterochromatin organization (GO:0070828)3.19706400
108negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19102275
109fatty acid homeostasis (GO:0055089)3.18241214
110regulation of translational fidelity (GO:0006450)3.18178044
111NADH metabolic process (GO:0006734)3.18080542
112positive regulation of triglyceride metabolic process (GO:0090208)3.17389807
113DNA strand elongation involved in DNA replication (GO:0006271)3.15055439
114regulation of RNA export from nucleus (GO:0046831)3.12130885
115activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.11821693
116DNA strand elongation (GO:0022616)3.09644366
117negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.08773746
118positive regulation of triglyceride biosynthetic process (GO:0010867)3.08320362
119regulation of translational termination (GO:0006449)3.08202250
120positive regulation of nuclease activity (GO:0032075)3.08106179
121mitotic sister chromatid segregation (GO:0000070)3.07872254
122ketone body metabolic process (GO:1902224)3.07777775
123organic acid catabolic process (GO:0016054)3.06252385
124carboxylic acid catabolic process (GO:0046395)3.06252385
125monocarboxylic acid catabolic process (GO:0072329)3.06208129
126regulation of NFAT protein import into nucleus (GO:0051532)3.06109903
127folic acid metabolic process (GO:0046655)3.04700409
128activation of Rac GTPase activity (GO:0032863)3.04664059
129positive regulation of lipid catabolic process (GO:0050996)3.03272172
130reverse cholesterol transport (GO:0043691)3.02418237
131planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02281766
132RNA stabilization (GO:0043489)3.01275449
133mRNA stabilization (GO:0048255)3.01275449
134phospholipid homeostasis (GO:0055091)3.00195209
135pentose-phosphate shunt (GO:0006098)2.99502282
136coenzyme catabolic process (GO:0009109)2.99141334
137ribosomal small subunit biogenesis (GO:0042274)2.99085179
138dicarboxylic acid metabolic process (GO:0043648)2.98119223
139maternal placenta development (GO:0001893)2.97918057
140protein export from nucleus (GO:0006611)2.97182489
141negative regulation of erythrocyte differentiation (GO:0045647)2.97074847
142branched-chain amino acid metabolic process (GO:0009081)2.96325773
143benzene-containing compound metabolic process (GO:0042537)2.95942498
144macromolecular complex remodeling (GO:0034367)2.95501846
145pore complex assembly (GO:0046931)2.94890556
146regulation of glucose import in response to insulin stimulus (GO:2001273)2.93736835
147DNA duplex unwinding (GO:0032508)2.88878459
148regulation of nucleobase-containing compound transport (GO:0032239)2.88441466
149mannose metabolic process (GO:0006013)2.87374604
150cytoskeletal anchoring at plasma membrane (GO:0007016)2.86509233
151basement membrane organization (GO:0071711)2.85086629
152regulation of histone H3-K27 methylation (GO:0061085)2.83692818
153protein-DNA complex disassembly (GO:0032986)2.82689506
154nucleosome disassembly (GO:0006337)2.82689506
155protein maturation by protein folding (GO:0022417)2.82556313
156regulation of translational elongation (GO:0006448)2.81746684
1573-UTR-mediated mRNA stabilization (GO:0070935)2.81632907
158intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.81155951
159endoplasmic reticulum unfolded protein response (GO:0030968)2.80710656
160regulation of nuclease activity (GO:0032069)2.77946271
161ER-nucleus signaling pathway (GO:0006984)2.76868915
162chromosome condensation (GO:0030261)2.74710549
163NADPH regeneration (GO:0006740)2.73887712
164histone arginine methylation (GO:0034969)2.73498353
165glucose catabolic process (GO:0006007)2.72251508
166sister chromatid segregation (GO:0000819)2.70965631
167cell-substrate junction assembly (GO:0007044)2.69888359
168protein localization to chromosome, centromeric region (GO:0071459)2.66635308
169regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.65246969
170mitotic nuclear envelope disassembly (GO:0007077)2.64812516
171UV protection (GO:0009650)2.64206922
172nucleobase-containing small molecule interconversion (GO:0015949)2.63395868
173mitochondrial fusion (GO:0008053)2.63263510
174DNA geometric change (GO:0032392)2.62965532
175peptidyl-arginine N-methylation (GO:0035246)2.61058392
176peptidyl-arginine methylation (GO:0018216)2.61058392
177glycolytic process (GO:0006096)2.60022271
178regulation of chromatin binding (GO:0035561)2.59083579
179regulation of cholesterol biosynthetic process (GO:0045540)2.57703079
180cellular response to unfolded protein (GO:0034620)2.57228563
181glutamine family amino acid biosynthetic process (GO:0009084)2.55196963
182membrane disassembly (GO:0030397)2.53828304
183nuclear envelope disassembly (GO:0051081)2.53828304
184monosaccharide biosynthetic process (GO:0046364)2.52938833
185pinocytosis (GO:0006907)2.52895909
186intracellular estrogen receptor signaling pathway (GO:0030520)2.52403487
187snRNA metabolic process (GO:0016073)2.51072960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.52370204
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.97454654
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.39381624
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.19173847
5E2F7_22180533_ChIP-Seq_HELA_Human3.90376752
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.30583752
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87870669
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.74277376
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.53616504
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.49682004
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.47378447
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.37975650
13CLOCK_20551151_ChIP-Seq_293T_Human2.37828057
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26122676
15ZNF263_19887448_ChIP-Seq_K562_Human2.25344576
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.20265090
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.12869130
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11658679
19MYC_22102868_ChIP-Seq_BL_Human2.01866773
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.01222216
21STAT3_1855785_ChIP-Seq_MESCs_Mouse1.88381776
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86522462
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85831393
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83108944
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77450783
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73027025
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.71941117
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71227316
29* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68646225
30AR_21909140_ChIP-Seq_LNCAP_Human1.63986118
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60886847
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58488258
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56805230
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56144984
35* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50916383
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.50014784
37* ATF3_27146783_Chip-Seq_COLON_Human1.47727584
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43606865
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.43340013
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.42518678
41KDM2B_26808549_Chip-Seq_K562_Human1.41642645
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.35569875
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33759438
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33674715
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32414960
46CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30212984
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.29383321
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.27999147
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27595406
50* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27542750
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27192643
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26943072
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24665041
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.24200866
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21426316
56RACK7_27058665_Chip-Seq_MCF-7_Human1.21324285
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21313714
58XRN2_22483619_ChIP-Seq_HELA_Human1.20784039
59VDR_21846776_ChIP-Seq_THP-1_Human1.20276450
60* LXR_22292898_ChIP-Seq_THP-1_Human1.20029544
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18987354
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17849479
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.16878475
64MAF_26560356_Chip-Seq_TH1_Human1.16752204
65SMC4_20622854_ChIP-Seq_HELA_Human1.15792863
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14016368
67MAF_26560356_Chip-Seq_TH2_Human1.12722676
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12305454
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.12269343
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11990283
71* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11124405
72* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09735199
73TP53_22127205_ChIP-Seq_IMR90_Human1.09140957
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08876807
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.07743844
76* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07661203
77* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06803630
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06406430
79* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06059654
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05570686
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05482360
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04649914
83VDR_24763502_ChIP-Seq_THP-1_Human1.04169538
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04165820
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03003641
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02838309
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02803641
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02407853
89KDM5A_27292631_Chip-Seq_BREAST_Human1.02184959
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01023036
91KDM2B_26808549_Chip-Seq_DND41_Human1.00707833
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00358559
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00144687
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99670447
95TCF7_22412390_ChIP-Seq_EML_Mouse0.99576883
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99219027
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98638650
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.97506576
99MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97252426
100* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96842271
101UBF1/2_26484160_Chip-Seq_HMECs_Human0.96530658
102UTX_26944678_Chip-Seq_JUKART_Human0.95855390
103TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94270966
104NCOR1_26117541_ChIP-Seq_K562_Human0.93475708
105GATA6_25053715_ChIP-Seq_YYC3_Human0.93353406
106* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92260464
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92108433
108OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90071083
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89412652
110* ETS1_20019798_ChIP-Seq_JURKAT_Human0.88812987
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88241875
112P68_20966046_ChIP-Seq_HELA_Human0.88178060
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86613015
114CHD1_26751641_Chip-Seq_LNCaP_Human0.86596740
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85952100
116* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.85718200
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85461889
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85413377
119HNF4A_19822575_ChIP-Seq_HepG2_Human0.84714762
120CREB1_26743006_Chip-Seq_LNCaP_Human0.84159876
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83913519
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83730502
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83674706
124* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82561722
125DCP1A_22483619_ChIP-Seq_HELA_Human0.81845960
126FOXA2_19822575_ChIP-Seq_HepG2_Human0.81642414
127* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81349400
128SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80729647
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.80416978
130TBX20_22080862_ChIP-Seq_HEART_Mouse0.80416978
131* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80321441
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79244867
133GATA1_22025678_ChIP-Seq_K562_Human0.79086634
134NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79038656
135* GABP_19822575_ChIP-Seq_HepG2_Human0.79032823
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78632448
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78603893

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.61369017
2MP0005360_urolithiasis5.10930169
3MP0005365_abnormal_bile_salt4.07964700
4MP0005085_abnormal_gallbladder_physiolo4.07578936
5MP0003806_abnormal_nucleotide_metabolis3.79790228
6MP0003705_abnormal_hypodermis_morpholog3.57493717
7MP0009840_abnormal_foam_cell2.96592657
8MP0008875_abnormal_xenobiotic_pharmacok2.94319133
9MP0003252_abnormal_bile_duct2.73492007
10MP0010329_abnormal_lipoprotein_level2.71289828
11MP0005058_abnormal_lysosome_morphology2.57752661
12MP0005083_abnormal_biliary_tract2.37282414
13MP0004858_abnormal_nervous_system2.36033988
14MP0005332_abnormal_amino_acid2.08659121
15MP0010094_abnormal_chromosome_stability2.03812551
16MP0002837_dystrophic_cardiac_calcinosis2.02079179
17MP0000678_abnormal_parathyroid_gland1.94363024
18MP0005670_abnormal_white_adipose1.90006912
19MP0009278_abnormal_bone_marrow1.88460701
20MP0000609_abnormal_liver_physiology1.87408188
21MP0003191_abnormal_cellular_cholesterol1.82981353
22MP0005666_abnormal_adipose_tissue1.81540584
23MP0008260_abnormal_autophagy1.77356592
24MP0003453_abnormal_keratinocyte_physiol1.74980866
25MP0004130_abnormal_muscle_cell1.73065017
26MP0001666_abnormal_nutrient_absorption1.67568523
27MP0005319_abnormal_enzyme/_coenzyme1.65467435
28MP0000350_abnormal_cell_proliferation1.63889356
29MP0004185_abnormal_adipocyte_glucose1.63507499
30MP0010352_gastrointestinal_tract_polyps1.61418864
31MP0003195_calcinosis1.59174171
32MP0000537_abnormal_urethra_morphology1.58924785
33MP0004084_abnormal_cardiac_muscle1.58641405
34MP0002118_abnormal_lipid_homeostasis1.58263592
35MP0005257_abnormal_intraocular_pressure1.46879997
36MP0008932_abnormal_embryonic_tissue1.46792858
37MP0008438_abnormal_cutaneous_collagen1.46530189
38MP0001348_abnormal_lacrimal_gland1.41690022
39MP0005501_abnormal_skin_physiology1.40992181
40MP0002269_muscular_atrophy1.39328940
41MP0005330_cardiomyopathy1.38144704
42MP0004808_abnormal_hematopoietic_stem1.37300269
43MP0002089_abnormal_postnatal_growth/wei1.35424610
44MP0003646_muscle_fatigue1.33261614
45MP0006036_abnormal_mitochondrial_physio1.30949151
46MP0003091_abnormal_cell_migration1.29808424
47MP0008007_abnormal_cellular_replicative1.27751941
48MP0002796_impaired_skin_barrier1.26559374
49MP0000598_abnormal_liver_morphology1.25531826
50MP0005409_darkened_coat_color1.23890203
51MP0002060_abnormal_skin_morphology1.23180683
52MP0005375_adipose_tissue_phenotype1.22806940
53MP0009643_abnormal_urine_homeostasis1.22524769
54MP0003221_abnormal_cardiomyocyte_apopto1.22417310
55MP0003329_amyloid_beta_deposits1.22349822
56MP0004019_abnormal_vitamin_homeostasis1.21422245
57MP0004087_abnormal_muscle_fiber1.21414941
58MP0005623_abnormal_meninges_morphology1.20882465
59MP0003566_abnormal_cell_adhesion1.20478756
60MP0002396_abnormal_hematopoietic_system1.19309797
61MP0005621_abnormal_cell_physiology1.19012099
62MP0008057_abnormal_DNA_replication1.15678636
63MP0002249_abnormal_larynx_morphology1.15608360
64MP0010630_abnormal_cardiac_muscle1.13671926
65MP0003172_abnormal_lysosome_physiology1.11088049
66MP0001730_embryonic_growth_arrest1.10743851
67MP0005076_abnormal_cell_differentiation1.10408142
68MP0010234_abnormal_vibrissa_follicle1.09507292
69MP0003186_abnormal_redox_activity1.08813004
70MP0003123_paternal_imprinting1.08744139
71MP0005584_abnormal_enzyme/coenzyme_acti1.08538093
72MP0000750_abnormal_muscle_regeneration1.08046151
73MP0000313_abnormal_cell_death1.07605700
74MP0009333_abnormal_splenocyte_physiolog1.07151634
75MP0000858_altered_metastatic_potential1.05610167
76MP0000751_myopathy1.03028337
77MP0010030_abnormal_orbit_morphology1.02096362
78MP0004957_abnormal_blastocyst_morpholog1.01961412
79MP0000747_muscle_weakness1.01835738
80MP0009672_abnormal_birth_weight1.00555410
81MP0004233_abnormal_muscle_weight0.98512225
82MP0002971_abnormal_brown_adipose0.97990247
83MP0005384_cellular_phenotype0.97213734
84MP0003656_abnormal_erythrocyte_physiolo0.96978039
85MP0004197_abnormal_fetal_growth/weight/0.96498890
86MP0005023_abnormal_wound_healing0.96013038
87MP0002085_abnormal_embryonic_tissue0.95818064
88MP0003984_embryonic_growth_retardation0.94978577
89MP0002088_abnormal_embryonic_growth/wei0.94957809
90MP0010307_abnormal_tumor_latency0.92943849
91MP0008775_abnormal_heart_ventricle0.92031851
92MP0004036_abnormal_muscle_relaxation0.91600947
93MP0000490_abnormal_crypts_of0.90572788
94MP0003567_abnormal_fetal_cardiomyocyte0.90526548
95MP0003868_abnormal_feces_composition0.90180612
96MP0009053_abnormal_anal_canal0.89633553
97MP0002138_abnormal_hepatobiliary_system0.89548428
98MP0001672_abnormal_embryogenesis/_devel0.89467384
99MP0005380_embryogenesis_phenotype0.89467384
100MP0005266_abnormal_metabolism0.89322204
101MP0006035_abnormal_mitochondrial_morpho0.88212123
102MP0003111_abnormal_nucleus_morphology0.87639406
103MP0006138_congestive_heart_failure0.85974668
104MP0002877_abnormal_melanocyte_morpholog0.85247894
105MP0003693_abnormal_embryo_hatching0.85168495
106MP0005385_cardiovascular_system_phenoty0.84647523
107MP0001544_abnormal_cardiovascular_syste0.84647523
108MP0008961_abnormal_basal_metabolism0.84124311
109MP0002970_abnormal_white_adipose0.83353636
110MP0002084_abnormal_developmental_patter0.82643934
111MP0009931_abnormal_skin_appearance0.82573122
112MP0002086_abnormal_extraembryonic_tissu0.80654915
113MP0000003_abnormal_adipose_tissue0.80297949
114MP0005451_abnormal_body_composition0.80050853
115MP0004947_skin_inflammation0.79866046
116MP0003300_gastrointestinal_ulcer0.79402278
117MP0002078_abnormal_glucose_homeostasis0.78703570
118MP0001764_abnormal_homeostasis0.78602288
119MP0003115_abnormal_respiratory_system0.77251130
120MP0005220_abnormal_exocrine_pancreas0.76138284
121MP0005334_abnormal_fat_pad0.74286763
122MP0002080_prenatal_lethality0.74197040
123MP0001915_intracranial_hemorrhage0.73980095
124MP0001697_abnormal_embryo_size0.72554305
125MP0001661_extended_life_span0.71829130
126MP0009115_abnormal_fat_cell0.71493077
127MP0000749_muscle_degeneration0.71419352
128MP0003077_abnormal_cell_cycle0.70387678
129MP0001216_abnormal_epidermal_layer0.70369141
130MP0001849_ear_inflammation0.68573179
131MP0003959_abnormal_lean_body0.67970320
132MP0004215_abnormal_myocardial_fiber0.67879203
133MP0000733_abnormal_muscle_development0.67702077
134MP0001756_abnormal_urination0.67168475
135MP0003634_abnormal_glial_cell0.66888572
136MP0002019_abnormal_tumor_incidence0.66693702
137MP0000358_abnormal_cell_content/0.65885502
138MP0004782_abnormal_surfactant_physiolog0.65836525
139MP0000467_abnormal_esophagus_morphology0.65762466
140MP0005397_hematopoietic_system_phenotyp0.65320387
141MP0001545_abnormal_hematopoietic_system0.65320387
142MP0009763_increased_sensitivity_to0.65036948
143MP0000759_abnormal_skeletal_muscle0.64681318
144MP0000566_synostosis0.64594890
145MP0003385_abnormal_body_wall0.64049865
146MP0010368_abnormal_lymphatic_system0.63151578
147MP0000266_abnormal_heart_morphology0.61866686
148MP0005636_abnormal_mineral_homeostasis0.60158279
149MP0004272_abnormal_basement_membrane0.59535588

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.05570448
2Intrahepatic cholestasis (HP:0001406)4.61109559
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.54132124
4Xanthomatosis (HP:0000991)4.54033607
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.35409423
6Hypobetalipoproteinemia (HP:0003563)4.08511138
7Hyperacusis (HP:0010780)4.07301775
8Hyperammonemia (HP:0001987)4.05143942
9Hyperglycinuria (HP:0003108)4.02313938
10Hypoglycemic coma (HP:0001325)3.96948322
11Ketosis (HP:0001946)3.86663565
12Abnormality of serine family amino acid metabolism (HP:0010894)3.81668918
13Abnormality of glycine metabolism (HP:0010895)3.81668918
14Hyperglycinemia (HP:0002154)3.72924593
15Hypolipoproteinemia (HP:0010981)3.50101780
16Hyperlipoproteinemia (HP:0010980)3.41120519
17Hypoalphalipoproteinemia (HP:0003233)3.37680283
18Myoglobinuria (HP:0002913)3.28902694
19Ketoacidosis (HP:0001993)3.27066415
20Abnormality of fatty-acid metabolism (HP:0004359)3.24719395
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.23550998
22Ulnar bowing (HP:0003031)3.20411700
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.15646732
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.14682317
25Complement deficiency (HP:0004431)3.12823778
26Spastic diplegia (HP:0001264)3.11878946
27Premature rupture of membranes (HP:0001788)3.08510500
28Insomnia (HP:0100785)3.05155908
29Epidermoid cyst (HP:0200040)3.01262854
30Rhabdomyolysis (HP:0003201)2.93811959
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.81110939
32Prolonged partial thromboplastin time (HP:0003645)2.78974823
33Multiple enchondromatosis (HP:0005701)2.78742700
34Vertebral compression fractures (HP:0002953)2.73943099
35Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72989649
36Abnormality of the common coagulation pathway (HP:0010990)2.72713802
37Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72325158
38Dicarboxylic aciduria (HP:0003215)2.72325158
39Progressive muscle weakness (HP:0003323)2.70771568
40Dysmetric saccades (HP:0000641)2.68227427
41Long palpebral fissure (HP:0000637)2.65806937
42Abnormal cartilage morphology (HP:0002763)2.65598800
43Gout (HP:0001997)2.64389828
44Increased connective tissue (HP:0009025)2.63673888
45Distal lower limb amyotrophy (HP:0008944)2.62275569
46Skin nodule (HP:0200036)2.62043034
47Abnormality of pyrimidine metabolism (HP:0004353)2.60724139
48Centrally nucleated skeletal muscle fibers (HP:0003687)2.60185924
49Disproportionate tall stature (HP:0001519)2.55898581
50Abnormality of methionine metabolism (HP:0010901)2.54497521
51Hepatocellular carcinoma (HP:0001402)2.53142047
52Abnormality of the intrinsic pathway (HP:0010989)2.52757153
53Exercise-induced muscle cramps (HP:0003710)2.52644667
54Abnormality of serum amino acid levels (HP:0003112)2.51255306
55Cholelithiasis (HP:0001081)2.44771803
56Abnormality of complement system (HP:0005339)2.41700347
57Abnormality of nucleobase metabolism (HP:0010932)2.38517602
58Hypercholesterolemia (HP:0003124)2.38089049
59Reticulocytosis (HP:0001923)2.37360787
60Late onset (HP:0003584)2.37341156
61Abnormality of the Achilles tendon (HP:0005109)2.37044907
62Lymphangioma (HP:0100764)2.34471821
63Myocardial infarction (HP:0001658)2.32792308
64Biconcave vertebral bodies (HP:0004586)2.30522252
65Hyperbilirubinemia (HP:0002904)2.29501675
66Cholecystitis (HP:0001082)2.28903374
67Abnormal gallbladder physiology (HP:0012438)2.28903374
68Neonatal onset (HP:0003623)2.27917570
69Abnormal gallbladder morphology (HP:0012437)2.27700249
70Abnormality of purine metabolism (HP:0004352)2.27414333
71Protrusio acetabuli (HP:0003179)2.26511278
72Right ventricular cardiomyopathy (HP:0011663)2.25009115
73Trismus (HP:0000211)2.23693940
74Back pain (HP:0003418)2.22509479
75Abnormality of the thoracic spine (HP:0100711)2.21686775
76Broad face (HP:0000283)2.20178419
77Fat malabsorption (HP:0002630)2.18910547
78Sparse lateral eyebrow (HP:0005338)2.16647171
79Myopathic facies (HP:0002058)2.14465299
80Metabolic acidosis (HP:0001942)2.12818361
81Ragged-red muscle fibers (HP:0003200)2.11635271
82Ankyloglossia (HP:0010296)2.09195827
83Esophageal varix (HP:0002040)2.08563617
84Lethargy (HP:0001254)2.05723102
85Thin bony cortex (HP:0002753)2.04418922
86Shallow orbits (HP:0000586)2.03701184
87Overriding aorta (HP:0002623)2.02227938
88Delayed CNS myelination (HP:0002188)2.01876091
89Premature skin wrinkling (HP:0100678)2.00815367
90Fragile skin (HP:0001030)2.00665292
91Renal duplication (HP:0000075)2.00464960
92Hyperinsulinemic hypoglycemia (HP:0000825)1.99818172
93Joint hemorrhage (HP:0005261)1.99552363
94Nausea (HP:0002018)1.99310223
95Hyperglycemia (HP:0003074)1.99051149
96Distal lower limb muscle weakness (HP:0009053)1.98385157
97Turricephaly (HP:0000262)1.98102045
98Pointed chin (HP:0000307)1.98044485
99Broad distal phalanx of finger (HP:0009836)1.97886126
100Elbow flexion contracture (HP:0002987)1.97387583
101Hydroxyprolinuria (HP:0003080)1.97357797
102Abnormality of proline metabolism (HP:0010907)1.97357797
103Pseudobulbar signs (HP:0002200)1.96925731
104Elfin facies (HP:0004428)1.96397273
105Polycythemia (HP:0001901)1.95975488
106Abnormality of reticulocytes (HP:0004312)1.95864939
107Truncus arteriosus (HP:0001660)1.95242086
108Spinal rigidity (HP:0003306)1.94711337
109Achilles tendon contracture (HP:0001771)1.94006134
110Abnormality of the calcaneus (HP:0008364)1.93417339
111Hyperuricemia (HP:0002149)1.93330383
112Increased purine levels (HP:0004368)1.93330383
113Flat acetabular roof (HP:0003180)1.91485490
114Patellar dislocation (HP:0002999)1.91057919
115Cerebral aneurysm (HP:0004944)1.90518482
116Ankle contracture (HP:0006466)1.90442947
117Stridor (HP:0010307)1.89241194
118Thoracic kyphosis (HP:0002942)1.88934235
119Hyporeflexia of lower limbs (HP:0002600)1.87908153
120Angiofibromas (HP:0010615)1.86293344
121Adenoma sebaceum (HP:0009720)1.86293344
122Hypoglycemic seizures (HP:0002173)1.86268435
123Global brain atrophy (HP:0002283)1.85412089
124Upper limb amyotrophy (HP:0009129)1.85394799
125Distal upper limb amyotrophy (HP:0007149)1.85394799
126Abnormality of the fingertips (HP:0001211)1.85353289
127Increased nuchal translucency (HP:0010880)1.85154259
128Progressive external ophthalmoplegia (HP:0000590)1.84916801
129Lower limb amyotrophy (HP:0007210)1.84147952
130Cerebral edema (HP:0002181)1.83995027
131Sudden death (HP:0001699)1.83267691
132Ventricular tachycardia (HP:0004756)1.82947746
133Deviation of the thumb (HP:0009603)1.82591578
134Selective tooth agenesis (HP:0001592)1.82389759
135Blue sclerae (HP:0000592)1.81179672
136Atrioventricular block (HP:0001678)1.81011521
137Advanced eruption of teeth (HP:0006288)1.80112087
138Hemorrhage of the eye (HP:0011885)1.79734529
139Bladder diverticulum (HP:0000015)1.79709617
140Insulin resistance (HP:0000855)1.79374190
141Generalized aminoaciduria (HP:0002909)1.79213439
142Deep palmar crease (HP:0006191)1.78578554
143Difficulty climbing stairs (HP:0003551)1.78309512
144Obstructive sleep apnea (HP:0002870)1.78179687
145Ependymoma (HP:0002888)1.76883149
146Increased variability in muscle fiber diameter (HP:0003557)1.76445648
147Short nail (HP:0001799)1.76323712
148Malnutrition (HP:0004395)1.76155823
149Breast hypoplasia (HP:0003187)1.76031407
150Asymmetry of the thorax (HP:0001555)1.75342890
151Abnormality of oral frenula (HP:0000190)1.75271554
152Mitral regurgitation (HP:0001653)1.74702181
153Abnormality of the gallbladder (HP:0005264)1.74411836
154Hand muscle atrophy (HP:0009130)1.74336942
155Natal tooth (HP:0000695)1.73740409
156Abnormality of iron homeostasis (HP:0011031)1.73546520
157Aneurysm (HP:0002617)1.73047425
158Generalized amyotrophy (HP:0003700)1.72935711
159Abnormality of the tricuspid valve (HP:0001702)1.72465871
160Cerebral inclusion bodies (HP:0100314)1.72439718
161Thin ribs (HP:0000883)1.71166394
162Exercise-induced myalgia (HP:0003738)1.70978307
163Microvesicular hepatic steatosis (HP:0001414)1.70871101
164Upper limb muscle weakness (HP:0003484)1.70088081
165Bowing of the arm (HP:0006488)1.69601583
166Bowed forearm bones (HP:0003956)1.69601583
167Proximal placement of thumb (HP:0009623)1.68901643
168Genu recurvatum (HP:0002816)1.67979994
169Hammertoe (HP:0001765)1.67908847
170Abnormality of glycolysis (HP:0004366)1.67629547
171Flat cornea (HP:0007720)1.65683293
172Abnormality of skeletal muscle fiber size (HP:0012084)1.64208002
173Squamous cell carcinoma (HP:0002860)1.63687038
174Upper motor neuron abnormality (HP:0002127)1.60770906
175Abnormal ossification of hand bones (HP:0005921)1.59401171
176Hyperparathyroidism (HP:0000843)1.59291821
177Bowel incontinence (HP:0002607)1.58921433
178Abnormality of carpal bone ossification (HP:0006257)1.58773274
179Nonimmune hydrops fetalis (HP:0001790)1.58276105
180Vertebral arch anomaly (HP:0008438)1.56148401
181Precocious puberty (HP:0000826)1.56091312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.06716467
2PKN24.96397535
3SMG14.26000703
4BCKDK3.92319752
5EEF2K3.22217001
6PRPF4B3.17726248
7IRAK32.97806689
8TTN2.74848621
9ERN12.71318583
10SIK12.49399154
11MAP3K102.44092771
12NEK12.43375133
13FLT32.06238217
14FGFR41.81861698
15CDK121.78921921
16PTK61.72679113
17LATS11.61074404
18PDK31.57376553
19PDK41.57376553
20RIPK11.51133749
21EPHA21.49926615
22PDGFRA1.49735045
23TAOK21.44928901
24NEK21.42471711
25SCYL21.38293874
26ARAF1.34931039
27MAP2K31.31609644
28MAP3K131.29054121
29CDK41.26930819
30MTOR1.25186879
31PRKD31.23607496
32LRRK21.22771972
33ICK1.16937618
34RPS6KB21.16934554
35WEE11.13593649
36BRAF1.12016180
37BMX1.10240156
38LATS21.09451033
39NME21.09398057
40PAK41.08886728
41TTK1.06632290
42PASK1.06175816
43MAPKAPK31.03423674
44MAPK111.03118221
45CDC71.01956705
46MAP3K81.00565780
47LMTK20.94903171
48MST1R0.94831710
49MET0.94500542
50CAMK1D0.93010526
51ALK0.88895458
52CDK60.88875485
53MAP3K90.88448976
54PIM20.85310754
55PAK20.82451652
56CHEK20.81946420
57NTRK10.79493377
58MAP3K30.79281599
59SIK20.77503566
60MAP3K70.76886575
61RPS6KA40.76273844
62PDPK10.75455318
63RPS6KA20.73229593
64ACVR1B0.71989475
65PTK20.70330319
66PDK20.68021016
67ERBB40.67928458
68STK38L0.65568603
69CDK80.64707582
70TGFBR10.64289292
71STK100.63379448
72TESK20.62997611
73CDK70.62325305
74CDC42BPA0.61662045
75IRAK20.61401219
76AKT20.61362994
77MAP3K110.60752919
78NEK90.60736557
79FGFR10.60703881
80TYRO30.59960070
81AURKB0.58509602
82ILK0.57865678
83MARK20.57527752
84KDR0.57154292
85BUB10.57151745
86EIF2AK10.56857633
87RET0.56706545
88STK30.53683959
89RAF10.53158306
90MAP3K10.52807000
91DDR20.51561155
92JAK20.50769220
93PRKAA10.50306117
94GRK60.49686275
95STK40.48051378
96BRSK20.47581599
97TAOK10.47305142
98PRKD20.46872534
99ATR0.46750408
100MAPK120.46209251
101KSR20.45728107
102CDK90.44475931
103RPS6KA60.44335288
104RPS6KA10.43958038
105PRKAA20.43920944
106ABL20.43175571
107MOS0.42549389
108MAP2K20.42365206
109PLK10.42178627
110CDK10.42137054
111BRSK10.40882621
112CDK11A0.40143408
113CLK10.40110733
114PIM10.39030591
115PAK10.37996773
116CHEK10.37839207
117DYRK1B0.37440905
118MAP2K10.37132112
119DAPK30.37122786
120TAOK30.36234166
121HIPK20.35759017
122TESK10.35357346
123CDK150.35025047
124GSK3A0.35020104
125OBSCN0.35014856
126PRKD10.33803877
127AURKA0.33102421
128MELK0.32829325
129CDK20.32458667
130MAP3K140.32445620
131TBK10.31433665
132CSNK1E0.31395291
133TSSK60.30565796
134EPHB10.29644760
135CAMKK10.29584166
136RPS6KL10.28739203
137RPS6KC10.28739203
138ERBB20.28550383
139CAMK1G0.28226259
140PDGFRB0.28191854
141TYK20.27016557

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.58758531
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.19759043
3Nitrogen metabolism_Homo sapiens_hsa009103.18448524
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.02067661
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.00116822
6Fatty acid degradation_Homo sapiens_hsa000712.80841815
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73106590
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.69302483
9Arginine biosynthesis_Homo sapiens_hsa002202.66530915
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.60914735
11Propanoate metabolism_Homo sapiens_hsa006402.46581113
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32049818
13Carbon metabolism_Homo sapiens_hsa012002.22198087
14Tryptophan metabolism_Homo sapiens_hsa003802.22184424
15Biosynthesis of amino acids_Homo sapiens_hsa012302.14742337
16Fatty acid metabolism_Homo sapiens_hsa012122.06242038
17Other glycan degradation_Homo sapiens_hsa005111.97861827
18PPAR signaling pathway_Homo sapiens_hsa033201.93547974
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.92820081
20Selenocompound metabolism_Homo sapiens_hsa004501.90017373
21Butanoate metabolism_Homo sapiens_hsa006501.89803415
22One carbon pool by folate_Homo sapiens_hsa006701.88637537
23Pyruvate metabolism_Homo sapiens_hsa006201.87301108
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67009895
25Complement and coagulation cascades_Homo sapiens_hsa046101.61802103
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59044853
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.58874211
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.58670336
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58436872
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.53406932
31Peroxisome_Homo sapiens_hsa041461.50877847
32Acute myeloid leukemia_Homo sapiens_hsa052211.49522968
33beta-Alanine metabolism_Homo sapiens_hsa004101.48877811
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42941976
35Cell cycle_Homo sapiens_hsa041101.39089763
36Lysine degradation_Homo sapiens_hsa003101.34299059
37Caffeine metabolism_Homo sapiens_hsa002321.33176877
38Pancreatic cancer_Homo sapiens_hsa052121.28673594
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28323300
40Fat digestion and absorption_Homo sapiens_hsa049751.26975333
41VEGF signaling pathway_Homo sapiens_hsa043701.26620116
42Bile secretion_Homo sapiens_hsa049761.21287481
43Phenylalanine metabolism_Homo sapiens_hsa003601.18353704
44Starch and sucrose metabolism_Homo sapiens_hsa005001.18033711
45Pentose phosphate pathway_Homo sapiens_hsa000301.17253476
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14152557
47mRNA surveillance pathway_Homo sapiens_hsa030151.13824286
48Notch signaling pathway_Homo sapiens_hsa043301.13276857
49Chemical carcinogenesis_Homo sapiens_hsa052041.11456419
50Spliceosome_Homo sapiens_hsa030401.11137718
51Sulfur relay system_Homo sapiens_hsa041221.10715641
52Tyrosine metabolism_Homo sapiens_hsa003501.10094078
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08231001
54Endometrial cancer_Homo sapiens_hsa052131.07508284
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.04668877
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04411607
57Folate biosynthesis_Homo sapiens_hsa007901.01558957
58Glioma_Homo sapiens_hsa052141.00772842
59Arginine and proline metabolism_Homo sapiens_hsa003300.99968303
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98886055
61MicroRNAs in cancer_Homo sapiens_hsa052060.97868965
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96430451
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95118925
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93760267
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89185892
66Renal cell carcinoma_Homo sapiens_hsa052110.88301400
67ErbB signaling pathway_Homo sapiens_hsa040120.88002713
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.87918691
69Retinol metabolism_Homo sapiens_hsa008300.86861177
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86356221
71Histidine metabolism_Homo sapiens_hsa003400.85862831
72N-Glycan biosynthesis_Homo sapiens_hsa005100.85083959
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.84856572
74Prostate cancer_Homo sapiens_hsa052150.82014823
75Vitamin B6 metabolism_Homo sapiens_hsa007500.80270924
76Nucleotide excision repair_Homo sapiens_hsa034200.78533521
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75343134
78Fatty acid biosynthesis_Homo sapiens_hsa000610.74989477
79Apoptosis_Homo sapiens_hsa042100.74956450
80B cell receptor signaling pathway_Homo sapiens_hsa046620.74177571
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73671836
82ABC transporters_Homo sapiens_hsa020100.72489957
83Fructose and mannose metabolism_Homo sapiens_hsa000510.72459715
84HTLV-I infection_Homo sapiens_hsa051660.71842291
85Insulin resistance_Homo sapiens_hsa049310.71200110
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.70488931
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69716940
88Glycerolipid metabolism_Homo sapiens_hsa005610.69645321
89Staphylococcus aureus infection_Homo sapiens_hsa051500.68384800
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.65578273
91Colorectal cancer_Homo sapiens_hsa052100.64666308
92Fatty acid elongation_Homo sapiens_hsa000620.64263300
93Sulfur metabolism_Homo sapiens_hsa009200.63869440
94Hepatitis B_Homo sapiens_hsa051610.63799307
95Glutathione metabolism_Homo sapiens_hsa004800.61876653
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61492704
97Galactose metabolism_Homo sapiens_hsa000520.61255253
98AMPK signaling pathway_Homo sapiens_hsa041520.59848766
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.56580845
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55974701
101Adherens junction_Homo sapiens_hsa045200.51045506
102Inositol phosphate metabolism_Homo sapiens_hsa005620.50552087
103Vitamin digestion and absorption_Homo sapiens_hsa049770.50238875
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49267125
105Prolactin signaling pathway_Homo sapiens_hsa049170.48270932
106GnRH signaling pathway_Homo sapiens_hsa049120.48110712
107Glucagon signaling pathway_Homo sapiens_hsa049220.47941550
108Vibrio cholerae infection_Homo sapiens_hsa051100.45428945
109Estrogen signaling pathway_Homo sapiens_hsa049150.44985867
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43762455
111DNA replication_Homo sapiens_hsa030300.43506406
112Hepatitis C_Homo sapiens_hsa051600.43190116
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42191539
114Epstein-Barr virus infection_Homo sapiens_hsa051690.40618170
115Lysosome_Homo sapiens_hsa041420.40479001
116Insulin signaling pathway_Homo sapiens_hsa049100.39745522
117Bladder cancer_Homo sapiens_hsa052190.39185250
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.37040944
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36543903
120Shigellosis_Homo sapiens_hsa051310.36406032
121Metabolic pathways_Homo sapiens_hsa011000.35636590
122Melanoma_Homo sapiens_hsa052180.35319157
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.34626017
124RNA transport_Homo sapiens_hsa030130.33512429
125ECM-receptor interaction_Homo sapiens_hsa045120.33468373
126mTOR signaling pathway_Homo sapiens_hsa041500.32793742
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31087394
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30731540
129Small cell lung cancer_Homo sapiens_hsa052220.22653968
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21810105
131Systemic lupus erythematosus_Homo sapiens_hsa053220.20132140
132Steroid biosynthesis_Homo sapiens_hsa001000.16762689
133Prion diseases_Homo sapiens_hsa050200.16305044
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16271081
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.15549102
136Thyroid cancer_Homo sapiens_hsa052160.14799961
137Mismatch repair_Homo sapiens_hsa034300.13794692
138HIF-1 signaling pathway_Homo sapiens_hsa040660.12126609
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10961395
140Chronic myeloid leukemia_Homo sapiens_hsa052200.10932017
141Pyrimidine metabolism_Homo sapiens_hsa002400.06561481
142Focal adhesion_Homo sapiens_hsa045100.04091664
143Proteoglycans in cancer_Homo sapiens_hsa052050.03806445
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03337862
145Base excision repair_Homo sapiens_hsa034100.03138153
146Non-small cell lung cancer_Homo sapiens_hsa052230.03114887
147Viral carcinogenesis_Homo sapiens_hsa052030.02216687
148Amoebiasis_Homo sapiens_hsa051460.00817878

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