LONP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.09038368
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.09038368
3L-phenylalanine metabolic process (GO:0006558)6.79269915
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.79269915
5aromatic amino acid family catabolic process (GO:0009074)6.41077893
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.04537993
7alpha-linolenic acid metabolic process (GO:0036109)5.87329246
8tryptophan catabolic process (GO:0006569)5.83181080
9indole-containing compound catabolic process (GO:0042436)5.83181080
10indolalkylamine catabolic process (GO:0046218)5.83181080
11kynurenine metabolic process (GO:0070189)5.74648088
12bile acid biosynthetic process (GO:0006699)5.73341250
13glyoxylate metabolic process (GO:0046487)5.50355544
14tryptophan metabolic process (GO:0006568)5.48777154
15urea cycle (GO:0000050)5.38217733
16urea metabolic process (GO:0019627)5.38217733
17sulfur amino acid catabolic process (GO:0000098)5.33088234
18cysteine metabolic process (GO:0006534)5.26618941
19high-density lipoprotein particle remodeling (GO:0034375)5.21635946
20complement activation, alternative pathway (GO:0006957)5.20902676
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.19159468
22negative regulation of fibrinolysis (GO:0051918)5.12061729
23regulation of protein activation cascade (GO:2000257)5.06474087
24protein carboxylation (GO:0018214)4.92864793
25peptidyl-glutamic acid carboxylation (GO:0017187)4.92864793
26nitrogen cycle metabolic process (GO:0071941)4.92508796
27bile acid metabolic process (GO:0008206)4.88172389
28serine family amino acid catabolic process (GO:0009071)4.87857330
29regulation of fibrinolysis (GO:0051917)4.87401038
30regulation of triglyceride catabolic process (GO:0010896)4.86372276
31homocysteine metabolic process (GO:0050667)4.81218298
32lysine metabolic process (GO:0006553)4.80336710
33lysine catabolic process (GO:0006554)4.80336710
34regulation of complement activation (GO:0030449)4.76029981
35amino-acid betaine metabolic process (GO:0006577)4.69760510
36aromatic amino acid family metabolic process (GO:0009072)4.65386574
37reverse cholesterol transport (GO:0043691)4.64723820
38cellular ketone body metabolic process (GO:0046950)4.55178042
39alpha-amino acid catabolic process (GO:1901606)4.51408323
40tyrosine metabolic process (GO:0006570)4.50263695
41triglyceride homeostasis (GO:0070328)4.50041997
42acylglycerol homeostasis (GO:0055090)4.50041997
43protein-lipid complex remodeling (GO:0034368)4.48546681
44macromolecular complex remodeling (GO:0034367)4.48546681
45plasma lipoprotein particle remodeling (GO:0034369)4.48546681
46exogenous drug catabolic process (GO:0042738)4.47016171
47regulation of cholesterol esterification (GO:0010872)4.46756548
48coenzyme catabolic process (GO:0009109)4.31703219
49phospholipid efflux (GO:0033700)4.26502712
50ethanol oxidation (GO:0006069)4.23882952
51cellular amino acid catabolic process (GO:0009063)4.21245386
52plasma lipoprotein particle clearance (GO:0034381)4.20667251
53negative regulation of cholesterol transport (GO:0032375)4.20553103
54negative regulation of sterol transport (GO:0032372)4.20553103
55bile acid and bile salt transport (GO:0015721)4.18227087
56indolalkylamine metabolic process (GO:0006586)4.12280280
57omega-hydroxylase P450 pathway (GO:0097267)4.10574123
58positive regulation of glycolytic process (GO:0045821)4.08863252
59glycine metabolic process (GO:0006544)4.07314674
60glutamate metabolic process (GO:0006536)4.04415374
61acetyl-CoA metabolic process (GO:0006084)4.00502801
62cellular biogenic amine catabolic process (GO:0042402)3.98143196
63amine catabolic process (GO:0009310)3.98143196
64cellular glucuronidation (GO:0052695)3.97354615
65serine family amino acid metabolic process (GO:0009069)3.96418948
66cholesterol efflux (GO:0033344)3.94846779
67short-chain fatty acid metabolic process (GO:0046459)3.94228097
68ketone body metabolic process (GO:1902224)3.93431008
69dicarboxylic acid biosynthetic process (GO:0043650)3.93165697
70benzene-containing compound metabolic process (GO:0042537)3.92409606
71cellular modified amino acid catabolic process (GO:0042219)3.92032825
72imidazole-containing compound metabolic process (GO:0052803)3.92005283
73fatty acid beta-oxidation (GO:0006635)3.88175771
742-oxoglutarate metabolic process (GO:0006103)3.86495750
75epoxygenase P450 pathway (GO:0019373)3.84841188
76positive regulation of fatty acid beta-oxidation (GO:0032000)3.82957590
77positive regulation of lipid catabolic process (GO:0050996)3.82948515
78fatty acid oxidation (GO:0019395)3.82469692
79organic acid catabolic process (GO:0016054)3.81543336
80carboxylic acid catabolic process (GO:0046395)3.81543336
81phospholipid homeostasis (GO:0055091)3.80651348
82arginine metabolic process (GO:0006525)3.80017323
83plasma lipoprotein particle assembly (GO:0034377)3.78780954
84valine metabolic process (GO:0006573)3.77162303
85serine family amino acid biosynthetic process (GO:0009070)3.75423187
86lipid oxidation (GO:0034440)3.75172267
87monocarboxylic acid catabolic process (GO:0072329)3.73464110
88fatty acid catabolic process (GO:0009062)3.71652120
89low-density lipoprotein particle remodeling (GO:0034374)3.71567310
90regulation of cholesterol homeostasis (GO:2000188)3.68192422
91negative regulation of protein activation cascade (GO:2000258)3.66367509
92drug catabolic process (GO:0042737)3.65629451
93cytolysis (GO:0019835)3.65398071
94carnitine metabolic process (GO:0009437)3.62557057
95very-low-density lipoprotein particle assembly (GO:0034379)3.60181621
96cofactor catabolic process (GO:0051187)3.58564420
97aspartate family amino acid catabolic process (GO:0009068)3.58441290
98complement activation, classical pathway (GO:0006958)3.57788853
99complement activation (GO:0006956)3.56866294
100negative regulation of lipase activity (GO:0060192)3.55427043
101fibrinolysis (GO:0042730)3.54699789
102positive regulation of triglyceride lipase activity (GO:0061365)3.53464606
103positive regulation of lipoprotein lipase activity (GO:0051006)3.53464606
104cholesterol homeostasis (GO:0042632)3.52739045
105regulation of bile acid biosynthetic process (GO:0070857)3.52431921
106negative regulation of complement activation (GO:0045916)3.43446783
107oxidative demethylation (GO:0070989)3.40262169
108phenylpropanoid metabolic process (GO:0009698)3.23328329
109regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.14242220
110regulation of energy homeostasis (GO:2000505)3.09423457
111flavonoid metabolic process (GO:0009812)3.04722548
112regulation of protein glycosylation (GO:0060049)3.00392313
113biotin metabolic process (GO:0006768)2.94303948
114purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.89333671
1153-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.89333671
116drug metabolic process (GO:0017144)2.87167058
117water-soluble vitamin biosynthetic process (GO:0042364)2.84397826
118cellular response to ethanol (GO:0071361)2.84204965
119macroautophagy (GO:0016236)2.83148548
120branched-chain amino acid catabolic process (GO:0009083)2.73589626
121negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72010600
122S-adenosylmethionine metabolic process (GO:0046500)2.67203152
123uronic acid metabolic process (GO:0006063)2.64937046
124glucuronate metabolic process (GO:0019585)2.64937046
125positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.57728114
126retinal metabolic process (GO:0042574)2.57068503
127inositol phosphate catabolic process (GO:0071545)2.56948406
128xenobiotic catabolic process (GO:0042178)2.56594827
129regulation of glycolytic process (GO:0006110)2.55925401
130regulation of hexokinase activity (GO:1903299)2.54937495
131regulation of glucokinase activity (GO:0033131)2.54937495
132Golgi to endosome transport (GO:0006895)2.50580834
133establishment of protein localization to Golgi (GO:0072600)2.48019695
134positive regulation of fatty acid oxidation (GO:0046321)2.47711738
135negative regulation of hormone biosynthetic process (GO:0032353)2.46531161
136negative regulation of neurological system process (GO:0031645)2.45691514
137fatty acid transmembrane transport (GO:1902001)2.41294784
138fatty acid homeostasis (GO:0055089)2.41269583
139negative regulation of humoral immune response (GO:0002921)2.40332299
140positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.40241817
141vascular smooth muscle contraction (GO:0014829)2.39761565
142ethanol metabolic process (GO:0006067)2.38115808
143amino-acid betaine transport (GO:0015838)2.36598797
144carnitine transport (GO:0015879)2.36598797
145monoubiquitinated protein deubiquitination (GO:0035520)2.34639500
146negative regulation of hormone metabolic process (GO:0032351)2.34580731
147regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.33190171
148melanin biosynthetic process (GO:0042438)2.33166108
149branched-chain amino acid metabolic process (GO:0009081)2.32044082
150polyol catabolic process (GO:0046174)2.31385430
151positive regulation of glycogen biosynthetic process (GO:0045725)2.30077328
152protein localization to Golgi apparatus (GO:0034067)2.29077736
153reflex (GO:0060004)2.27824396
154estrogen metabolic process (GO:0008210)2.27142801
155COPII vesicle coating (GO:0048208)2.25758859
156regulation of lipoprotein metabolic process (GO:0050746)2.25694667
157dentate gyrus development (GO:0021542)2.25322349
158nitric oxide mediated signal transduction (GO:0007263)2.23149545
159secondary metabolite biosynthetic process (GO:0044550)2.23133556
160quaternary ammonium group transport (GO:0015697)2.22907511
161melanin metabolic process (GO:0006582)2.22365166
162glial cell proliferation (GO:0014009)2.22280701
163protein targeting to Golgi (GO:0000042)2.22050869
164endocrine pancreas development (GO:0031018)2.21837123
165keratinocyte development (GO:0003334)2.21045401
166brain morphogenesis (GO:0048854)2.18566126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.04595017
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.93948497
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.53627519
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.27290850
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.86611887
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.06089893
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.77278134
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.98101652
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.78535424
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.20837455
11GBX2_23144817_ChIP-Seq_PC3_Human3.12964300
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73540657
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.66165451
14* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.63455270
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60629609
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53377426
17* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.42507388
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.33436613
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11415951
20* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08980631
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08177033
22IGF1R_20145208_ChIP-Seq_DFB_Human2.04306391
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.01935498
24CLOCK_20551151_ChIP-Seq_293T_Human2.01402556
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3525146
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.91962012
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.90494324
28* SMAD4_21799915_ChIP-Seq_A2780_Human1.90242347
29FUS_26573619_Chip-Seq_HEK293_Human1.86863360
30ZNF274_21170338_ChIP-Seq_K562_Hela1.81189390
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.79134658
32GATA1_22025678_ChIP-Seq_K562_Human1.75334548
33* STAT3_23295773_ChIP-Seq_U87_Human1.75093483
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74120233
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71178676
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69474198
37ER_23166858_ChIP-Seq_MCF-7_Human1.68495866
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.68452155
39TCF4_23295773_ChIP-Seq_U87_Human1.63313704
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.63035676
41AHR_22903824_ChIP-Seq_MCF-7_Human1.56868068
42* P300_19829295_ChIP-Seq_ESCs_Human1.56034856
43* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53896292
44* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.53237864
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50148493
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.49177466
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48806273
48HTT_18923047_ChIP-ChIP_STHdh_Human1.44953307
49CBP_20019798_ChIP-Seq_JUKART_Human1.44793262
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44793262
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.44593003
52AR_25329375_ChIP-Seq_VCAP_Human1.43523572
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41759233
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40806662
55* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40204608
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39471862
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.39321466
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.38997131
59HNF4A_19822575_ChIP-Seq_HepG2_Human1.38408331
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38365310
61TP53_16413492_ChIP-PET_HCT116_Human1.36029728
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34269891
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32854280
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.32804926
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32282061
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30692204
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29490881
68TP53_18474530_ChIP-ChIP_U2OS_Human1.27833237
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25182300
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24191896
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24170612
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24033114
73VDR_22108803_ChIP-Seq_LS180_Human1.23656502
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23614206
75TCF4_22108803_ChIP-Seq_LS180_Human1.20054269
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19973692
77AR_21572438_ChIP-Seq_LNCaP_Human1.18798764
78P53_22387025_ChIP-Seq_ESCs_Mouse1.18701972
79EWS_26573619_Chip-Seq_HEK293_Human1.18623700
80* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18271100
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17727283
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.17364838
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16041048
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.15715931
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.14721695
86CJUN_26792858_Chip-Seq_BT549_Human1.13176310
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.12730058
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.11659062
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11466813
90RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09832433
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.09247533
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09211728
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08623335
94RUNX2_22187159_ChIP-Seq_PCA_Human1.07768166
95* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07424687
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06605509
97CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05631379
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04942157
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.04343270
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03835191
101RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02766707
102TAL1_26923725_Chip-Seq_HPCs_Mouse1.02540765
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.02527611
104SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01791400
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01398508
106STAT3_18555785_Chip-Seq_ESCs_Mouse0.99776586
107PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99406841
108IRF8_22096565_ChIP-ChIP_GC-B_Human0.98833614
109SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95822258
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95016225
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94905693
112ZNF263_19887448_ChIP-Seq_K562_Human0.93692482
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89085430
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85310309
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84046839
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80540370
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80276946
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79148620
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77672219
120GATA4_25053715_ChIP-Seq_YYC3_Human0.77243936
121* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76602060
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.76377921
123KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74544783
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73798800
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73798800
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70441994
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69774311
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.67997302
129TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.67363982
130PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63885424
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63750414
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61524655
133CEBPB_22108803_ChIP-Seq_LS180_Human0.60183285
134RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59173073
135RARB_24833708_ChIP-Seq_LIVER_Mouse0.59011177
136AR_20517297_ChIP-Seq_VCAP_Human0.56096075
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.55438240
138BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55238686
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55058456
140GATA1_19941827_ChIP-Seq_MEL_Mouse0.54904013
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.52811277
142CBP_21632823_ChIP-Seq_H3396_Human0.51922091
143BCAT_22108803_ChIP-Seq_LS180_Human0.51918353
144RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.51373071
145PPAR_26484153_Chip-Seq_NCI-H1993_Human0.50965958
146GATA2_19941826_ChIP-Seq_K562_Human0.50281513
147GATA1_19941826_ChIP-Seq_K562_Human0.50194595
148ESR1_21235772_ChIP-Seq_MCF-7_Human0.49904046
149MYC_19915707_ChIP-ChIP_AK7_Human0.49896649
150STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49603624
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.49500467
152STAT1_17558387_ChIP-Seq_HELA_Human0.48949628
153PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.48729534
154TAF15_26573619_Chip-Seq_HEK293_Human0.47938146
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46890035
156EGR1_19032775_ChIP-ChIP_M12_Human0.45392094
157FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.44703287
158ESET_19884257_ChIP-Seq_ESCs_Mouse0.44296763
159P53_21459846_ChIP-Seq_SAOS-2_Human0.44206830
160* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.43689869
161ERG_20517297_ChIP-Seq_VCAP_Human0.42927145
162PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.42784523
163PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.42356187
164LXR_22292898_ChIP-Seq_THP-1_Human0.42232134
165SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41509187
166SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41357962
167TBX20_22080862_ChIP-Seq_HEART_Mouse0.40635774
168TBX20_22328084_ChIP-Seq_HEART_Mouse0.40635774
169* ESR1_20079471_ChIP-ChIP_T-47D_Human0.40370532
170PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40253759
171FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.39576370
172GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.39486532
173CDX2_22108803_ChIP-Seq_LS180_Human0.38889635
174GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.38648127
175NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.38461636
176GATA3_24758297_ChIP-Seq_MCF-7_Human0.38265379
177GATA2_21666600_ChIP-Seq_HMVEC_Human0.38242696
178TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.38162106
179FOXH1_21741376_ChIP-Seq_EPCs_Human0.37954627
180CDX2_20551321_ChIP-Seq_CACO-2_Human0.36793503
181LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36442726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.02833585
2MP0005360_urolithiasis7.18807176
3MP0005365_abnormal_bile_salt6.19526951
4MP0005085_abnormal_gallbladder_physiolo6.13333839
5MP0008875_abnormal_xenobiotic_pharmacok4.93138405
6MP0003806_abnormal_nucleotide_metabolis4.06952929
7MP0003252_abnormal_bile_duct3.82992531
8MP0010329_abnormal_lipoprotein_level3.70886206
9MP0000372_irregular_coat_pigmentation3.35382549
10MP0009840_abnormal_foam_cell3.13612215
11MP0009780_abnormal_chondrocyte_physiolo3.09251009
12MP0005083_abnormal_biliary_tract2.84834381
13MP0005332_abnormal_amino_acid2.77435297
14MP0005171_absent_coat_pigmentation2.74208157
15MP0000569_abnormal_digit_pigmentation2.67587452
16MP0001666_abnormal_nutrient_absorption2.58963300
17MP0003195_calcinosis2.56673684
18MP0003646_muscle_fatigue2.41909985
19MP0003191_abnormal_cellular_cholesterol2.36818845
20MP0005075_abnormal_melanosome_morpholog2.28768955
21MP0002118_abnormal_lipid_homeostasis2.22205373
22MP0000609_abnormal_liver_physiology2.20994979
23MP0002909_abnormal_adrenal_gland2.05972117
24MP0004019_abnormal_vitamin_homeostasis2.05103309
25MP0002138_abnormal_hepatobiliary_system1.87039620
26MP0005319_abnormal_enzyme/_coenzyme1.85361401
27MP0003868_abnormal_feces_composition1.84704936
28MP0000427_abnormal_hair_cycle1.79558740
29MP0001764_abnormal_homeostasis1.70449766
30MP0005670_abnormal_white_adipose1.69636950
31MP0000015_abnormal_ear_pigmentation1.68489973
32MP0005584_abnormal_enzyme/coenzyme_acti1.65304093
33MP0000371_diluted_coat_color1.63466867
34MP0005646_abnormal_pituitary_gland1.62183298
35MP0005187_abnormal_penis_morphology1.60391798
36MP0009697_abnormal_copulation1.58839162
37MP0008775_abnormal_heart_ventricle1.57308796
38MP0000013_abnormal_adipose_tissue1.57263438
39MP0010386_abnormal_urinary_bladder1.57171728
40MP0005551_abnormal_eye_electrophysiolog1.54555213
41MP0005174_abnormal_tail_pigmentation1.50461268
42MP0001984_abnormal_olfaction1.44002614
43MP0004130_abnormal_muscle_cell1.42125090
44MP0003186_abnormal_redox_activity1.37908879
45MP0002102_abnormal_ear_morphology1.36871569
46MP0003011_delayed_dark_adaptation1.35813969
47MP0005253_abnormal_eye_physiology1.33829166
48MP0005248_abnormal_Harderian_gland1.33431481
49MP0009643_abnormal_urine_homeostasis1.32857285
50MP0005451_abnormal_body_composition1.30820546
51MP0010678_abnormal_skin_adnexa1.23738076
52MP0003656_abnormal_erythrocyte_physiolo1.23686560
53MP0002938_white_spotting1.23304436
54MP0002638_abnormal_pupillary_reflex1.22193755
55MP0009046_muscle_twitch1.21212589
56MP0002166_altered_tumor_susceptibility1.19635512
57MP0004381_abnormal_hair_follicle1.17338734
58MP0000598_abnormal_liver_morphology1.16743032
59MP0005379_endocrine/exocrine_gland_phen1.16364118
60MP0000538_abnormal_urinary_bladder1.13268645
61MP0001501_abnormal_sleep_pattern1.12517976
62MP0005647_abnormal_sex_gland1.11924871
63MP0003705_abnormal_hypodermis_morpholog1.10118340
64MP0003045_fibrosis1.09911614
65MP0006036_abnormal_mitochondrial_physio1.09759205
66MP0002095_abnormal_skin_pigmentation1.07731859
67MP0002876_abnormal_thyroid_physiology1.06811943
68MP0002075_abnormal_coat/hair_pigmentati1.06357031
69MP0001986_abnormal_taste_sensitivity1.05025766
70MP0000604_amyloidosis1.04998016
71MP0009764_decreased_sensitivity_to1.04926821
72MP0000516_abnormal_urinary_system1.04625638
73MP0005367_renal/urinary_system_phenotyp1.04625638
74MP0004924_abnormal_behavior1.04077800
75MP0005386_behavior/neurological_phenoty1.04077800
76MP0004134_abnormal_chest_morphology1.03052450
77MP0001324_abnormal_eye_pigmentation1.01785100
78MP0002254_reproductive_system_inflammat1.00973909
79MP0002837_dystrophic_cardiac_calcinosis0.99423949
80MP0002078_abnormal_glucose_homeostasis0.96684823
81MP0002971_abnormal_brown_adipose0.96551986
82MP0009763_increased_sensitivity_to0.96540148
83MP0000383_abnormal_hair_follicle0.96191120
84MP0005636_abnormal_mineral_homeostasis0.95234631
85MP0001661_extended_life_span0.95189304
86MP0010368_abnormal_lymphatic_system0.94853115
87MP0006072_abnormal_retinal_apoptosis0.94782415
88MP0000613_abnormal_salivary_gland0.94026799
89MP0005334_abnormal_fat_pad0.91056128
90MP0005535_abnormal_body_temperature0.90883639
91MP0005666_abnormal_adipose_tissue0.90193819
92MP0004885_abnormal_endolymph0.90154153
93MP0003136_yellow_coat_color0.89158572
94MP0001270_distended_abdomen0.88918352
95MP0009642_abnormal_blood_homeostasis0.88802715
96MP0005084_abnormal_gallbladder_morpholo0.87742220
97MP0005645_abnormal_hypothalamus_physiol0.86929770
98MP0003950_abnormal_plasma_membrane0.86577681
99MP0003633_abnormal_nervous_system0.85020783
100MP0008469_abnormal_protein_level0.84940285
101MP0003787_abnormal_imprinting0.84712760
102MP0002009_preneoplasia0.82827931
103MP0005376_homeostasis/metabolism_phenot0.81219849
104MP0003122_maternal_imprinting0.80373869
105MP0004270_analgesia0.78786908
106MP0004484_altered_response_of0.75896238
107MP0001186_pigmentation_phenotype0.75034465
108MP0004085_abnormal_heartbeat0.74165822
109MP0005448_abnormal_energy_balance0.74001033
110MP0002557_abnormal_social/conspecific_i0.73809702
111MP0005266_abnormal_metabolism0.73337243
112MP0002160_abnormal_reproductive_system0.73210425
113MP0010352_gastrointestinal_tract_polyps0.72575125
114MP0004036_abnormal_muscle_relaxation0.72416448
115MP0001756_abnormal_urination0.72019149
116MP0002234_abnormal_pharynx_morphology0.71876448
117MP0005220_abnormal_exocrine_pancreas0.71869402
118MP0002693_abnormal_pancreas_physiology0.71770887
119MP0003329_amyloid_beta_deposits0.71511312
120MP0009765_abnormal_xenobiotic_induced0.71302824
121MP0006035_abnormal_mitochondrial_morpho0.68764422
122MP0003690_abnormal_glial_cell0.68714549
123MP0000003_abnormal_adipose_tissue0.67880905
124MP0005408_hypopigmentation0.60061111
125MP0009115_abnormal_fat_cell0.57243599
126MP0003724_increased_susceptibility_to0.55329486
127MP0000639_abnormal_adrenal_gland0.54547703
128MP0003953_abnormal_hormone_level0.52498366
129MP0004782_abnormal_surfactant_physiolog0.51564041
130MP0002822_catalepsy0.50786105
131MP0005464_abnormal_platelet_physiology0.50503225
132MP0002136_abnormal_kidney_physiology0.49840703
133MP0002928_abnormal_bile_duct0.49308631
134MP0002970_abnormal_white_adipose0.48085231
135MP0000230_abnormal_systemic_arterial0.47990260
136MP0005395_other_phenotype0.43331980
137MP0008874_decreased_physiological_sensi0.42919891
138MP0003638_abnormal_response/metabolism_0.42822925
139MP0003075_altered_response_to0.41555905
140MP0004185_abnormal_adipocyte_glucose0.41257345
141MP0005375_adipose_tissue_phenotype0.40001754
142MP0001881_abnormal_mammary_gland0.38166199
143MP0001853_heart_inflammation0.37287529
144MP0004043_abnormal_pH_regulation0.36875187
145MP0002168_other_aberrant_phenotype0.36179194
146MP0008872_abnormal_physiological_respon0.35851787
147MP0008873_increased_physiological_sensi0.35654487
148MP0005166_decreased_susceptibility_to0.34672455
149MP0003959_abnormal_lean_body0.34374184
150MP0002269_muscular_atrophy0.34055822
151MP0002090_abnormal_vision0.34037637
152MP0005058_abnormal_lysosome_morphology0.33207458
153MP0009672_abnormal_birth_weight0.32711831
154MP0000249_abnormal_blood_vessel0.32583935
155MP0009384_cardiac_valve_regurgitation0.31290959
156MP0003718_maternal_effect0.29033971
157MP0005330_cardiomyopathy0.28099309
158MP0005452_abnormal_adipose_tissue0.28042290
159MP0004147_increased_porphyrin_level0.27942460
160MP0001944_abnormal_pancreas_morphology0.27691308
161MP0004264_abnormal_extraembryonic_tissu0.27393675
162MP0005595_abnormal_vascular_smooth0.27348020
163MP0010234_abnormal_vibrissa_follicle0.26705429

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.88569718
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.81148337
3Deep venous thrombosis (HP:0002625)6.79388932
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.08687085
5Xanthomatosis (HP:0000991)6.07541794
6Prolonged partial thromboplastin time (HP:0003645)5.97718237
7Hypobetalipoproteinemia (HP:0003563)5.90590135
8Hyperlipoproteinemia (HP:0010980)5.38750851
9Complement deficiency (HP:0004431)5.23603372
10Hyperammonemia (HP:0001987)4.75782443
11Hypolipoproteinemia (HP:0010981)4.63999466
12Hyperglycinemia (HP:0002154)4.53171305
13Ketosis (HP:0001946)4.46579049
14Epidermoid cyst (HP:0200040)4.43642612
15Hyperglycinuria (HP:0003108)4.30746817
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.28822658
17Joint hemorrhage (HP:0005261)4.25660570
18Hypoalphalipoproteinemia (HP:0003233)4.22590171
19Cutaneous melanoma (HP:0012056)4.19428431
20Abnormality of serine family amino acid metabolism (HP:0010894)4.19158151
21Abnormality of glycine metabolism (HP:0010895)4.19158151
22Hypoglycemic coma (HP:0001325)4.18879443
23Abnormality of the common coagulation pathway (HP:0010990)4.08017138
24Blue irides (HP:0000635)4.01903982
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.01444981
26Fat malabsorption (HP:0002630)3.99613321
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.99010328
28Hyperventilation (HP:0002883)3.97471175
29Abnormality of methionine metabolism (HP:0010901)3.88236929
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.87828307
31Abnormality of fatty-acid metabolism (HP:0004359)3.81157598
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.75814432
33Abnormality of complement system (HP:0005339)3.66867646
34Abnormality of the intrinsic pathway (HP:0010989)3.66496267
35Conjugated hyperbilirubinemia (HP:0002908)3.59032173
36Ketoacidosis (HP:0001993)3.50109466
37Hypercholesterolemia (HP:0003124)3.42626138
38Abnormality of pyrimidine metabolism (HP:0004353)3.34127657
39Generalized hypopigmentation of hair (HP:0011358)3.24038099
40Hyperbilirubinemia (HP:0002904)3.22481260
41Abnormality of serum amino acid levels (HP:0003112)3.18427847
42Fair hair (HP:0002286)3.16623500
43Delayed CNS myelination (HP:0002188)3.05306900
44Abnormality of nucleobase metabolism (HP:0010932)3.04743520
45Steatorrhea (HP:0002570)3.01265697
46Dicarboxylic aciduria (HP:0003215)2.94085185
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.94085185
48Metabolic acidosis (HP:0001942)2.91880081
49Skin nodule (HP:0200036)2.90349421
50Abnormality of purine metabolism (HP:0004352)2.90051451
51Spontaneous abortion (HP:0005268)2.84729166
52Myocardial infarction (HP:0001658)2.84486200
53Hepatocellular carcinoma (HP:0001402)2.80163004
54Hypothermia (HP:0002045)2.77397730
55Thyroiditis (HP:0100646)2.76909314
56Lethargy (HP:0001254)2.74033840
57Abnormality of the renal cortex (HP:0011035)2.70922417
58Hemiparesis (HP:0001269)2.69328533
59Gaze-evoked nystagmus (HP:0000640)2.65921722
60Hypoglycemic seizures (HP:0002173)2.65064390
61Gout (HP:0001997)2.64967093
62Chronic hepatic failure (HP:0100626)2.58872715
63Hamartoma of the eye (HP:0010568)2.56837744
64Systemic lupus erythematosus (HP:0002725)2.56663206
65Large for gestational age (HP:0001520)2.55724356
66Abnormal gallbladder morphology (HP:0012437)2.53300496
67Hypochromic microcytic anemia (HP:0004840)2.50659185
68Cholelithiasis (HP:0001081)2.50339642
69Cerebral edema (HP:0002181)2.50112986
70Acanthocytosis (HP:0001927)2.48989999
71Sensorimotor neuropathy (HP:0007141)2.43622369
72Generalized aminoaciduria (HP:0002909)2.43149217
73Spastic diplegia (HP:0001264)2.40518253
74Calf muscle hypertrophy (HP:0008981)2.39988340
75Abnormal gallbladder physiology (HP:0012438)2.36500489
76Cholecystitis (HP:0001082)2.36500489
77Brushfield spots (HP:0001088)2.32271639
78Irritability (HP:0000737)2.31169438
79Neonatal onset (HP:0003623)2.30752498
80Macroorchidism (HP:0000053)2.27615280
81Congenital stationary night blindness (HP:0007642)2.26197468
82Mitral stenosis (HP:0001718)2.25868171
83Pancreatitis (HP:0001733)2.25201146
84Congenital sensorineural hearing impairment (HP:0008527)2.24207823
85Vascular calcification (HP:0004934)2.23604223
86Neoplasm of the adrenal cortex (HP:0100641)2.23168958
87Late onset (HP:0003584)2.20602252
88Progressive cerebellar ataxia (HP:0002073)2.19438116
89Vomiting (HP:0002013)2.17781692
90Pancreatic cysts (HP:0001737)2.17460843
91Renal cortical cysts (HP:0000803)2.15492668
92Recurrent gram-negative bacterial infections (HP:0005420)2.13239570
93Esophageal varix (HP:0002040)2.11874274
94EEG with generalized epileptiform discharges (HP:0011198)2.10148134
95Malnutrition (HP:0004395)2.09283480
96Albinism (HP:0001022)2.08899380
97Epileptiform EEG discharges (HP:0011182)2.08349052
98Medial flaring of the eyebrow (HP:0010747)2.07959785
99Hyperinsulinemic hypoglycemia (HP:0000825)2.07570758
100Ocular albinism (HP:0001107)2.07545289
101Abnormality of the gallbladder (HP:0005264)2.07135614
102Generalized hypopigmentation (HP:0007513)2.05200379
103Glomerulonephritis (HP:0000099)2.04992915
104Cystic liver disease (HP:0006706)2.03857419
105Amyloidosis (HP:0011034)2.03832846
106Insulin-resistant diabetes mellitus (HP:0000831)2.01555828
107Abnormality of proline metabolism (HP:0010907)1.99838348
108Hydroxyprolinuria (HP:0003080)1.99838348
109Hypsarrhythmia (HP:0002521)1.99446930
110Pancreatic fibrosis (HP:0100732)1.99274028
111Cardiovascular calcification (HP:0011915)1.99143820
112Abnormality of vitamin metabolism (HP:0100508)1.98864749
113Gingival bleeding (HP:0000225)1.97911057
114Enlarged kidneys (HP:0000105)1.96192423
115Muscle hypertrophy of the lower extremities (HP:0008968)1.96070194
116Hemorrhage of the eye (HP:0011885)1.95921666
117Aplasia/Hypoplasia of the fovea (HP:0008060)1.95295288
118Hypoplasia of the fovea (HP:0007750)1.95295288
119Abnormal cartilage morphology (HP:0002763)1.95162959
120Elevated hepatic transaminases (HP:0002910)1.94398535
121Hyperuricemia (HP:0002149)1.94024480
122Increased purine levels (HP:0004368)1.94024480
123Abnormality of endocrine pancreas physiology (HP:0012093)1.93957872
124Abnormality of the pancreatic islet cells (HP:0006476)1.93957872
125Hypertriglyceridemia (HP:0002155)1.93860686
126Hyperglycemia (HP:0003074)1.93736691
127Febrile seizures (HP:0002373)1.92766620
128Abnormality of the nasal septum (HP:0000419)1.92644837
129Abnormal biliary tract physiology (HP:0012439)1.92614990
130Bile duct proliferation (HP:0001408)1.92614990
131Thrombophlebitis (HP:0004418)1.92531318
132Neoplasm of the heart (HP:0100544)1.92307473
133Methylmalonic acidemia (HP:0002912)1.92162130
134Menorrhagia (HP:0000132)1.90689605
135Abnormality of the renal medulla (HP:0100957)1.89464864
136Lymphangioma (HP:0100764)1.88910618
137Opisthotonus (HP:0002179)1.88440624
138Nephronophthisis (HP:0000090)1.88355004
139Meningioma (HP:0002858)1.87265861
140Metaphyseal dysplasia (HP:0100255)1.86991900
141Proximal tubulopathy (HP:0000114)1.86807961
142Poikilocytosis (HP:0004447)1.85481242
143Type II lissencephaly (HP:0007260)1.85397402
144True hermaphroditism (HP:0010459)1.84754815
145Lip pit (HP:0100267)1.83110764
146Hematochezia (HP:0002573)1.81258744
147Widely spaced teeth (HP:0000687)1.80422403
148Abnormality of vitamin B metabolism (HP:0004340)1.78802639
149Acute hepatic failure (HP:0006554)1.78424725
150Myoglobinuria (HP:0002913)1.77777270
151Tubular atrophy (HP:0000092)1.76099926
152Nausea (HP:0002018)1.75642613
153Status epilepticus (HP:0002133)1.73794175
154Abnormal pancreas size (HP:0012094)1.73760041
155Patchy hypopigmentation of hair (HP:0011365)1.72606398
156Symptomatic seizures (HP:0011145)1.72595549
157Absent speech (HP:0001344)1.72499404
158Urinary glycosaminoglycan excretion (HP:0003541)1.71822147
159Mucopolysacchariduria (HP:0008155)1.71822147
160White forelock (HP:0002211)1.71470541
161Testicular neoplasm (HP:0010788)1.71350548
162Aplasia/Hypoplasia of the macula (HP:0008059)1.70988030
163Abnormality of the fovea (HP:0000493)1.69715127
164Thyroid carcinoma (HP:0002890)1.67919362
165Iris hypopigmentation (HP:0007730)1.67714673
166Disproportionate short-trunk short stature (HP:0003521)1.67275902

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.99596003
2SIK14.49482895
3FGFR44.13475547
4ERN13.88722696
5INSRR3.20778648
6TRIB32.84188308
7TAOK32.80347686
8BMPR1B2.50260309
9MAP4K22.32076669
10PKN22.26457128
11ERBB42.20302850
12MAP2K42.19018318
13STK392.13744375
14FLT31.88636731
15MAPK111.79638156
16FER1.75194769
17PIK3CG1.73114956
18TIE11.66040768
19PDK31.65863257
20PDK41.65863257
21FRK1.64756694
22ACVR1B1.63710127
23ERBB31.55258562
24CAMK1D1.55240853
25MST1R1.50250570
26TYK21.48167111
27NLK1.47706523
28NEK91.46080342
29DAPK21.43836010
30CAMKK21.38848985
31TRPM71.36693745
32MAP3K21.36580480
33CASK1.36384435
34PRKAA21.32752805
35NTRK31.29611792
36OBSCN1.29548379
37MAP3K71.28673872
38EIF2AK31.27434360
39PINK11.26807136
40PTK61.24676805
41KDR1.24432062
42BRSK21.23326431
43FGFR21.21204806
44MAPK131.19342892
45CSNK1A1L1.17041073
46JAK11.16236869
47MAP2K31.16020696
48WNK41.15265255
49JAK21.14336511
50LATS11.12157419
51WNK31.11845602
52MAPKAPK31.04403919
53OXSR10.98515015
54ADRBK20.97403166
55RIPK10.97054968
56PLK20.96242378
57ABL20.96068082
58TBK10.93420761
59PDK20.93382508
60PRKAA10.91391022
61TGFBR20.90635075
62SGK30.88289618
63CSNK1G30.87423993
64PRKCE0.86160752
65EPHA30.83464601
66MAPK120.83365821
67STK38L0.82980756
68CAMK1G0.82556393
69FGFR30.82099280
70CSNK1G20.81728450
71SGK20.80238329
72MAPK40.78053624
73LMTK20.77683608
74GRK60.74133642
75MARK10.71027919
76PRKACG0.69310041
77NUAK10.66399083
78MYLK0.65564611
79PTK2B0.65089993
80PDPK10.65031251
81MAP3K30.64995217
82WNK10.64828875
83RET0.64154273
84ERBB20.63304589
85PRKCZ0.62225307
86PIK3CA0.60582595
87MAP3K100.59934202
88IRAK30.59796772
89MAP3K40.59247175
90SGK2230.57945719
91SGK4940.57945719
92ADRBK10.57436584
93MAP3K60.57309203
94MAPK70.56887771
95MAP2K60.56695004
96PDK10.54706073
97MAP2K10.54583831
98STK240.54075617
99CAMK2G0.54040013
100IKBKE0.53791144
101CDK60.53756406
102STK30.52254054
103TEC0.51854189
104IGF1R0.51209261
105BCR0.51086301
106MET0.49015707
107MAP3K50.48588106
108MARK30.48148085
109BMPR20.48027568
110SGK10.47981357
111JAK30.47974911
112CSNK1D0.47831359
113IRAK10.46873689
114GSK3A0.46659672
115MAP3K140.45984981
116EEF2K0.45341671
117TNK20.45114716
118CSF1R0.44641928
119PRKCH0.44050326
120PAK60.41896954
121PTK20.41099139
122AKT30.40806090
123PRKCQ0.39901428
124TGFBR10.39742510
125PRKCG0.39586619
126CSK0.39186826
127ZAP700.39176676
128MAP3K110.39168208
129CCNB10.38740472
130MAP3K130.38538614
131STK110.38317649
132DYRK1B0.38245507
133MKNK20.37507277
134CSNK1A10.37417407
135NEK10.37397155
136MAP4K10.37124346
137PAK30.36841749
138PHKG10.36809320
139PHKG20.36809320
140PRKD30.36215812
141ITK0.36030184
142RPS6KB10.34790055
143HIPK20.34635171
144EPHB10.33337765
145TAOK20.32678615
146CHUK0.32631727
147CAMK2A0.32420613
148PRKACA0.31847423
149KIT0.30372192
150CAMK40.28169775
151CSNK1G10.27194933
152CAMKK10.26628742
153FGFR10.25958387
154GRK10.25276415
155STK380.24571780
156PDGFRA0.24551449

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.31288442
2Nitrogen metabolism_Homo sapiens_hsa009103.43275521
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25949951
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17759989
5Arginine biosynthesis_Homo sapiens_hsa002202.88765261
6Fatty acid degradation_Homo sapiens_hsa000712.76836019
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75089010
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71179398
9Tryptophan metabolism_Homo sapiens_hsa003802.67039105
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.66821385
11Complement and coagulation cascades_Homo sapiens_hsa046102.52769637
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38173781
13Propanoate metabolism_Homo sapiens_hsa006402.37689060
14Butanoate metabolism_Homo sapiens_hsa006502.29179126
15Peroxisome_Homo sapiens_hsa041462.16174838
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11853345
17Fatty acid metabolism_Homo sapiens_hsa012122.09378077
18PPAR signaling pathway_Homo sapiens_hsa033202.09105921
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97443549
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85536993
21Caffeine metabolism_Homo sapiens_hsa002321.83695290
22beta-Alanine metabolism_Homo sapiens_hsa004101.80137435
23Chemical carcinogenesis_Homo sapiens_hsa052041.79788998
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75881793
25Histidine metabolism_Homo sapiens_hsa003401.74924404
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.73754758
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67755090
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65166751
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.65022442
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63382714
31Pyruvate metabolism_Homo sapiens_hsa006201.61802756
32Retinol metabolism_Homo sapiens_hsa008301.57484079
33Staphylococcus aureus infection_Homo sapiens_hsa051501.52958008
34Phenylalanine metabolism_Homo sapiens_hsa003601.50866467
35Selenocompound metabolism_Homo sapiens_hsa004501.45941400
36Bile secretion_Homo sapiens_hsa049761.45253466
37Fatty acid elongation_Homo sapiens_hsa000621.40187638
38Tyrosine metabolism_Homo sapiens_hsa003501.38449088
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36846799
40Carbon metabolism_Homo sapiens_hsa012001.34785771
41Starch and sucrose metabolism_Homo sapiens_hsa005001.31908618
42Sulfur metabolism_Homo sapiens_hsa009201.31450729
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.27894292
44Biosynthesis of amino acids_Homo sapiens_hsa012301.26896956
45Insulin secretion_Homo sapiens_hsa049111.20314968
46ABC transporters_Homo sapiens_hsa020101.19903848
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17179781
48Fat digestion and absorption_Homo sapiens_hsa049751.16437331
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14601083
50Folate biosynthesis_Homo sapiens_hsa007901.06174274
51Vitamin B6 metabolism_Homo sapiens_hsa007501.05728858
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03803541
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94419771
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.93452640
55Steroid biosynthesis_Homo sapiens_hsa001000.91579733
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.90455009
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89216852
58Arginine and proline metabolism_Homo sapiens_hsa003300.86398061
59Vitamin digestion and absorption_Homo sapiens_hsa049770.85250053
60Glycerolipid metabolism_Homo sapiens_hsa005610.84216951
61Renin secretion_Homo sapiens_hsa049240.83716517
62Sulfur relay system_Homo sapiens_hsa041220.83605837
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82354325
64Lysine degradation_Homo sapiens_hsa003100.81855354
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81226997
66Fatty acid biosynthesis_Homo sapiens_hsa000610.80358370
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79151013
68Ether lipid metabolism_Homo sapiens_hsa005650.72704242
69Phototransduction_Homo sapiens_hsa047440.72456737
70Sphingolipid metabolism_Homo sapiens_hsa006000.70610634
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66805890
72Salivary secretion_Homo sapiens_hsa049700.65164301
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64198513
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.62636684
75Pentose phosphate pathway_Homo sapiens_hsa000300.62179673
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60887375
77Dorso-ventral axis formation_Homo sapiens_hsa043200.60392479
78Glutathione metabolism_Homo sapiens_hsa004800.58476575
79mTOR signaling pathway_Homo sapiens_hsa041500.57879771
80Circadian entrainment_Homo sapiens_hsa047130.55528494
81Pancreatic secretion_Homo sapiens_hsa049720.55500022
82Protein export_Homo sapiens_hsa030600.54923308
83One carbon pool by folate_Homo sapiens_hsa006700.51963002
84Metabolic pathways_Homo sapiens_hsa011000.45638358
85Mineral absorption_Homo sapiens_hsa049780.44903938
86Serotonergic synapse_Homo sapiens_hsa047260.44867066
87FoxO signaling pathway_Homo sapiens_hsa040680.44706040
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43960289
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41517829
90Calcium signaling pathway_Homo sapiens_hsa040200.40787540
91Amphetamine addiction_Homo sapiens_hsa050310.39486978
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.39325940
93Long-term depression_Homo sapiens_hsa047300.38759042
94Glutamatergic synapse_Homo sapiens_hsa047240.38311365
95Dopaminergic synapse_Homo sapiens_hsa047280.37633889
96Insulin resistance_Homo sapiens_hsa049310.37026904
97Fructose and mannose metabolism_Homo sapiens_hsa000510.35004905
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34254854
99Galactose metabolism_Homo sapiens_hsa000520.34243806
100Inositol phosphate metabolism_Homo sapiens_hsa005620.32181097
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29617659
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29209510
103Prion diseases_Homo sapiens_hsa050200.27930613
104Glucagon signaling pathway_Homo sapiens_hsa049220.24682656
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.21389321
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20844558
107AMPK signaling pathway_Homo sapiens_hsa041520.17767456
108Linoleic acid metabolism_Homo sapiens_hsa005910.10431064
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06120445
110Insulin signaling pathway_Homo sapiens_hsa049100.03786932
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00398485
112Amoebiasis_Homo sapiens_hsa05146-0.2427525
113Arachidonic acid metabolism_Homo sapiens_hsa00590-0.2276275
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1983767
115Type II diabetes mellitus_Homo sapiens_hsa04930-0.1973821
116Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1961300
117Renin-angiotensin system_Homo sapiens_hsa04614-0.1704208
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1680438
119Hepatitis C_Homo sapiens_hsa05160-0.1672448
120Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1652007
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1621042
122Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1581444
123Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1252070
124Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1233499
125Circadian rhythm_Homo sapiens_hsa04710-0.1093321
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1055224
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0982926
128Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0767231
129Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0688857
130Regulation of autophagy_Homo sapiens_hsa04140-0.0455977

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