LONRF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)7.03983216
2polyketide metabolic process (GO:0030638)7.03983216
3doxorubicin metabolic process (GO:0044598)7.03983216
4response to pheromone (GO:0019236)5.91998026
5mitotic sister chromatid cohesion (GO:0007064)5.30379327
6synapsis (GO:0007129)5.28138779
7nuclear pore complex assembly (GO:0051292)4.72118038
8DNA synthesis involved in DNA repair (GO:0000731)4.65017968
9regulation of histone H3-K9 methylation (GO:0051570)4.29087073
10aminoglycoside antibiotic metabolic process (GO:0030647)4.27628069
11nuclear pore organization (GO:0006999)4.15781235
12histone H3-K9 demethylation (GO:0033169)4.00463960
13pre-miRNA processing (GO:0031054)3.99776034
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.94222294
15sister chromatid cohesion (GO:0007062)3.86377303
16regulation of meiosis I (GO:0060631)3.72156310
17vocalization behavior (GO:0071625)3.71627200
18auditory receptor cell stereocilium organization (GO:0060088)3.68364392
19chromosome organization involved in meiosis (GO:0070192)3.67828362
20negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.59847055
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.58879169
22cerebral cortex radially oriented cell migration (GO:0021799)3.55870101
23negative regulation of synaptic transmission, GABAergic (GO:0032229)3.55346915
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.53952795
25pore complex assembly (GO:0046931)3.53205939
26G-protein coupled receptor internalization (GO:0002031)3.51620394
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.44794096
28energy homeostasis (GO:0097009)3.44513269
29histone exchange (GO:0043486)3.44093653
30mitotic metaphase plate congression (GO:0007080)3.42435371
31acrosome assembly (GO:0001675)3.39456199
32paraxial mesoderm development (GO:0048339)3.38982110
33neuron cell-cell adhesion (GO:0007158)3.38570881
34detection of molecule of bacterial origin (GO:0032490)3.37892969
35genitalia morphogenesis (GO:0035112)3.37190754
36inner ear receptor stereocilium organization (GO:0060122)3.35429328
37protein localization to kinetochore (GO:0034501)3.34201080
38regulation of glutamate receptor signaling pathway (GO:1900449)3.32213420
39neuron remodeling (GO:0016322)3.31849990
40histone H3-K36 demethylation (GO:0070544)3.28992494
41male meiosis (GO:0007140)3.27797607
42positive regulation of neurotransmitter secretion (GO:0001956)3.26232961
43glutamate receptor signaling pathway (GO:0007215)3.25286843
44NLS-bearing protein import into nucleus (GO:0006607)3.24604355
45anterior/posterior axis specification, embryo (GO:0008595)3.23269044
46regulation of gene silencing by RNA (GO:0060966)3.21389715
47regulation of posttranscriptional gene silencing (GO:0060147)3.21389715
48regulation of gene silencing by miRNA (GO:0060964)3.21389715
49chromatin remodeling at centromere (GO:0031055)3.19466319
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15817498
51presynaptic membrane assembly (GO:0097105)3.15307986
52CENP-A containing nucleosome assembly (GO:0034080)3.14389171
53regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.10418774
54regulation of NFAT protein import into nucleus (GO:0051532)3.10165723
55piRNA metabolic process (GO:0034587)3.09262518
56sulfate transmembrane transport (GO:1902358)3.04187380
57startle response (GO:0001964)3.02635713
58regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.00173637
59negative regulation of DNA-dependent DNA replication (GO:2000104)2.99082079
60regulation of DNA endoreduplication (GO:0032875)2.97497201
61metaphase plate congression (GO:0051310)2.96943362
62synaptic transmission, glutamatergic (GO:0035249)2.96689899
63single strand break repair (GO:0000012)2.96460788
64glycosphingolipid biosynthetic process (GO:0006688)2.95449481
65cellular anion homeostasis (GO:0030002)2.94149164
66synaptonemal complex assembly (GO:0007130)2.93406999
67regulation of chromatin silencing (GO:0031935)2.93010292
68negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.92308267
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92308267
70negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92308267
71negative regulation of mitotic sister chromatid separation (GO:2000816)2.92308267
72negative regulation of sister chromatid segregation (GO:0033046)2.92308267
73male meiosis I (GO:0007141)2.92225962
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91311305
75regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91311305
76embryonic retina morphogenesis in camera-type eye (GO:0060059)2.91158433
77regulation of sister chromatid segregation (GO:0033045)2.91115426
78regulation of mitotic sister chromatid separation (GO:0010965)2.91115426
79regulation of mitotic sister chromatid segregation (GO:0033047)2.91115426
80positive regulation of SMAD protein import into nucleus (GO:0060391)2.90223152
81atrial cardiac muscle cell action potential (GO:0086014)2.90032943
82mitotic G2/M transition checkpoint (GO:0044818)2.89952191
83serotonin receptor signaling pathway (GO:0007210)2.89615312
84dendritic spine organization (GO:0097061)2.87279667
85locomotory exploration behavior (GO:0035641)2.86543949
86centrosome localization (GO:0051642)2.86534853
87positive regulation of catenin import into nucleus (GO:0035413)2.85169392
88negative regulation of histone methylation (GO:0031061)2.83142377
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.81939467
90synaptic vesicle endocytosis (GO:0048488)2.81532498
91spindle checkpoint (GO:0031577)2.81342222
92negative regulation of chromosome segregation (GO:0051985)2.80916012
93protein localization to synapse (GO:0035418)2.80398566
94proline transport (GO:0015824)2.79728092
95histone lysine demethylation (GO:0070076)2.79041274
96mitotic G2 DNA damage checkpoint (GO:0007095)2.78621076
97ATP-dependent chromatin remodeling (GO:0043044)2.78238119
98protein localization to chromosome, centromeric region (GO:0071459)2.76867894
99protein localization to chromosome (GO:0034502)2.76816448
100negative regulation of fibroblast apoptotic process (GO:2000270)2.76565791
101postsynaptic membrane organization (GO:0001941)2.76494419
102mitotic spindle checkpoint (GO:0071174)2.74493246
103negative regulation of DNA repair (GO:0045738)2.73716009
104gamma-aminobutyric acid signaling pathway (GO:0007214)2.71582363
105drinking behavior (GO:0042756)2.69708164
106synaptonemal complex organization (GO:0070193)2.69480456
107positive regulation of CREB transcription factor activity (GO:0032793)2.68483623
108presynaptic membrane organization (GO:0097090)2.67163860
109central nervous system projection neuron axonogenesis (GO:0021952)2.65875329
110positive regulation of neurotransmitter transport (GO:0051590)2.65836573
111meiotic nuclear division (GO:0007126)2.65754298
112dorsal/ventral axis specification (GO:0009950)2.65415099
113neuron-neuron synaptic transmission (GO:0007270)2.64880643
114DNA replication-independent nucleosome assembly (GO:0006336)2.64635871
115DNA replication-independent nucleosome organization (GO:0034724)2.64635871
116establishment of chromosome localization (GO:0051303)2.64539642
117opioid receptor signaling pathway (GO:0038003)2.64509456
118regulation of chromosome segregation (GO:0051983)2.63614107
119mitotic spindle assembly checkpoint (GO:0007094)2.61833160
120post-embryonic morphogenesis (GO:0009886)2.60044494
121positive regulation of chromosome segregation (GO:0051984)2.60008298
122lateral ventricle development (GO:0021670)2.59825594
123IMP metabolic process (GO:0046040)2.59430671
124negative regulation of gene silencing (GO:0060969)2.59404809
125histone demethylation (GO:0016577)2.59019488
126negative regulation of NF-kappaB import into nucleus (GO:0042347)2.58376184
127superoxide anion generation (GO:0042554)2.58016304
128monoubiquitinated protein deubiquitination (GO:0035520)2.57681090
129sulfate transport (GO:0008272)2.56993241
130gastrulation with mouth forming second (GO:0001702)2.56588217
131spindle assembly checkpoint (GO:0071173)2.56485040
132regulation of synaptic vesicle exocytosis (GO:2000300)2.55687091
133regulation of gene silencing (GO:0060968)2.52214722
134positive regulation of neurological system process (GO:0031646)2.51887213
135neuron recognition (GO:0008038)2.51665248
136histone H3-K4 trimethylation (GO:0080182)2.51360642
137somite rostral/caudal axis specification (GO:0032525)2.51126407
138regulation of short-term neuronal synaptic plasticity (GO:0048172)2.50222490
139axonal fasciculation (GO:0007413)2.49951654
140L-serine metabolic process (GO:0006563)2.49775059
141positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.49228336
142regulation of centriole replication (GO:0046599)2.48188122
143negative regulation of meiosis (GO:0045835)2.48178360
144dendritic spine morphogenesis (GO:0060997)2.47855125
145long-chain fatty acid biosynthetic process (GO:0042759)2.46435329
146histone H3-K9 modification (GO:0061647)2.46115026
147nodal signaling pathway (GO:0038092)2.45081068
148regulation of synaptic transmission, glutamatergic (GO:0051966)2.44660245
149exploration behavior (GO:0035640)2.44478447
150positive regulation of cell cycle checkpoint (GO:1901978)2.44066411
151embryonic body morphogenesis (GO:0010172)2.44032255
152apical protein localization (GO:0045176)2.43800738
153negative regulation of macroautophagy (GO:0016242)2.43626042
154regulation of DNA methylation (GO:0044030)2.43525545
155neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.43124657
156vitamin catabolic process (GO:0009111)2.42344447
157fat-soluble vitamin catabolic process (GO:0042363)2.42344447
158regulation of collateral sprouting (GO:0048670)2.41460138
159regulation of cell fate specification (GO:0042659)2.41404924
160prostate gland growth (GO:0060736)2.40947945
161prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.40828306
162heterochromatin organization (GO:0070828)2.40271638
163regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.39782265
164positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.38944538
165urinary tract smooth muscle contraction (GO:0014848)2.38484882
166righting reflex (GO:0060013)2.37711994
167dendrite development (GO:0016358)2.33842315
168long term synaptic depression (GO:0060292)2.32964963
169trivalent inorganic anion homeostasis (GO:0072506)2.32896133
170phosphate ion homeostasis (GO:0055062)2.32896133
171positive regulation of synaptic transmission, GABAergic (GO:0032230)2.32766506
172regulation of mitotic spindle checkpoint (GO:1903504)2.31273297
173regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.31273297
174developmental pigmentation (GO:0048066)2.30988500
175regulation of fever generation (GO:0031620)2.29614147
176positive regulation of heat generation (GO:0031652)2.29397296
177regulation of non-canonical Wnt signaling pathway (GO:2000050)2.28328044
178negative regulation of systemic arterial blood pressure (GO:0003085)2.26055213
179glycine transport (GO:0015816)2.26006100
180neuronal ion channel clustering (GO:0045161)2.25920823
181regulation of synaptic transmission, GABAergic (GO:0032228)2.25634049
182regulation of synaptic vesicle transport (GO:1902803)2.25015326
183detection of external biotic stimulus (GO:0098581)2.24757203
184regulation of postsynaptic membrane potential (GO:0060078)2.24333621
185negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.24146831
186negative regulation of translation, ncRNA-mediated (GO:0040033)2.24146831
187regulation of translation, ncRNA-mediated (GO:0045974)2.24146831
188regulation of excitatory postsynaptic membrane potential (GO:0060079)2.23346408
189innervation (GO:0060384)2.22361629
190negative regulation of neurotransmitter transport (GO:0051589)2.22003028
191regulation of pigment cell differentiation (GO:0050932)2.19802593
192regulation of neurotransmitter secretion (GO:0046928)2.19059231
193membrane hyperpolarization (GO:0060081)2.19045194
194positive regulation of dendritic spine morphogenesis (GO:0061003)2.18951332

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.76130177
2EZH2_22144423_ChIP-Seq_EOC_Human4.36226541
3GBX2_23144817_ChIP-Seq_PC3_Human4.24951722
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.99553032
5E2F7_22180533_ChIP-Seq_HELA_Human3.08852380
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.67639145
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.67639145
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.67639145
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.51879458
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.43289631
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38720131
12TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.38292273
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31806181
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29086280
15IGF1R_20145208_ChIP-Seq_DFB_Human2.21547198
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15380381
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.15161285
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.13416361
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.12671903
20* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.07388099
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05608212
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.03476074
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02467909
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.02136252
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.02073691
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00092764
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96914299
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.96525169
29* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95818665
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93782775
31P300_19829295_ChIP-Seq_ESCs_Human1.93741081
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92531175
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92130469
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92130469
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.87793044
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.87642981
37TAF15_26573619_Chip-Seq_HEK293_Human1.84415628
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84394165
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.83277218
40SMAD4_21799915_ChIP-Seq_A2780_Human1.83267487
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81765948
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81532291
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70547094
44AR_21572438_ChIP-Seq_LNCaP_Human1.69936508
45FUS_26573619_Chip-Seq_HEK293_Human1.69785669
46TP53_16413492_ChIP-PET_HCT116_Human1.66364480
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.66317107
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65765714
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.65205136
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64800682
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62640279
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.61840571
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.61839101
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60726182
55REST_21632747_ChIP-Seq_MESCs_Mouse1.60594361
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57297604
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56006229
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55815978
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55043864
60RNF2_27304074_Chip-Seq_NSC_Mouse1.54599405
61VDR_22108803_ChIP-Seq_LS180_Human1.53711656
62STAT3_23295773_ChIP-Seq_U87_Human1.51923270
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.51465525
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.51404187
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.51022999
66ER_23166858_ChIP-Seq_MCF-7_Human1.50382134
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50267618
68DROSHA_22980978_ChIP-Seq_HELA_Human1.49917079
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49515947
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48699141
71AR_21909140_ChIP-Seq_LNCAP_Human1.48692006
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.48450930
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46855242
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45537464
75EWS_26573619_Chip-Seq_HEK293_Human1.44710419
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44290420
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.42798738
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42595399
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42011064
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41558882
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41235665
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40998962
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39847468
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39847468
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.39127302
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39087372
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38304849
88AR_25329375_ChIP-Seq_VCAP_Human1.37701461
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37526832
90* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36876201
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36854849
92TCF3_18692474_ChIP-Seq_MESCs_Mouse1.35608131
93TCF4_23295773_ChIP-Seq_U87_Human1.34385353
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.33519580
95P53_22127205_ChIP-Seq_FIBROBLAST_Human1.32611348
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31789784
97P53_22387025_ChIP-Seq_ESCs_Mouse1.31329733
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.30362399
99SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30143902
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.29187380
101TP53_18474530_ChIP-ChIP_U2OS_Human1.27920748
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26201449
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.25716171
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24670211
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23627551
106* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23592183
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22722132
108TBX3_20139965_ChIP-Seq_MESCs_Mouse1.22238441
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22022968
110SMAD3_21741376_ChIP-Seq_HESCs_Human1.21604915
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21009194
112TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20957267
113* RUNX2_22187159_ChIP-Seq_PCA_Human1.20864154
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19596462
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.18577471
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.18482015
117* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17081289
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15921201
119PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15383008
120FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15155119
121AHR_22903824_ChIP-Seq_MCF-7_Human1.14723840
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.14673043
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14253069
124CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13442637
125SOX9_26525672_Chip-Seq_HEART_Mouse1.12257814
126NMYC_18555785_Chip-Seq_ESCs_Mouse1.11294894
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11214700
128SOX2_18555785_Chip-Seq_ESCs_Mouse1.11201684
129POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11174195
130JUN_21703547_ChIP-Seq_K562_Human1.10774692
131* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10753377
132YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09539553
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09457144
134TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09434317
135P300_18555785_Chip-Seq_ESCs_Mouse1.09072863
136OCT4_18555785_Chip-Seq_ESCs_Mouse1.08923813
137NANOG_16153702_ChIP-ChIP_HESCs_Human1.08532445
138* RXR_22108803_ChIP-Seq_LS180_Human1.07034189
139TP63_19390658_ChIP-ChIP_HaCaT_Human1.06897915
140SOX2_21211035_ChIP-Seq_LN229_Gbm1.06589074
141FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06512021
142ISL1_27105846_Chip-Seq_CPCs_Mouse1.05549955
143E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03523350
144SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02772809
145CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02188727
146TCF4_18268006_ChIP-ChIP_LS174T_Human1.02015626
147ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01721782
148PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01446691
149STAT3_18555785_ChIP-Seq_MESCs_Mouse1.00719395
150SOX2_16153702_ChIP-ChIP_HESCs_Human0.99948978
151CLOCK_20551151_ChIP-Seq_293T_Human0.99581093
152E2F1_21310950_ChIP-Seq_MCF-7_Human0.97547546
153CBP_20019798_ChIP-Seq_JUKART_Human0.97527770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.87263006
2MP0008057_abnormal_DNA_replication3.71491585
3MP0003880_abnormal_central_pattern3.60349332
4MP0004859_abnormal_synaptic_plasticity3.42919539
5MP0006292_abnormal_olfactory_placode2.97543055
6MP0001188_hyperpigmentation2.72204663
7MP0000569_abnormal_digit_pigmentation2.65233669
8MP0005645_abnormal_hypothalamus_physiol2.61392872
9MP0002735_abnormal_chemical_nociception2.55749863
10MP0002277_abnormal_respiratory_mucosa2.53640012
11MP0001486_abnormal_startle_reflex2.51659276
12MP0000566_synostosis2.49859880
13MP0002796_impaired_skin_barrier2.47569610
14MP0008004_abnormal_stomach_pH2.46623753
15MP0005423_abnormal_somatic_nervous2.34026254
16MP0003787_abnormal_imprinting2.33769436
17MP0002254_reproductive_system_inflammat2.31522954
18MP0001968_abnormal_touch/_nociception2.27940701
19MP0003635_abnormal_synaptic_transmissio2.23139525
20MP0003567_abnormal_fetal_cardiomyocyte2.21801944
21MP0010234_abnormal_vibrissa_follicle2.20987492
22MP0005646_abnormal_pituitary_gland2.20636091
23MP0003878_abnormal_ear_physiology2.19039947
24MP0005377_hearing/vestibular/ear_phenot2.19039947
25MP0009672_abnormal_birth_weight2.12239956
26MP0009745_abnormal_behavioral_response2.11615748
27MP0004742_abnormal_vestibular_system2.10968143
28MP0006276_abnormal_autonomic_nervous2.06853794
29MP0002063_abnormal_learning/memory/cond2.04125108
30MP0002736_abnormal_nociception_after1.97982459
31MP0002572_abnormal_emotion/affect_behav1.97876512
32MP0010094_abnormal_chromosome_stability1.92299532
33MP0009697_abnormal_copulation1.86672507
34MP0005171_absent_coat_pigmentation1.85262506
35MP0003123_paternal_imprinting1.83457578
36MP0001346_abnormal_lacrimal_gland1.79194346
37MP0001501_abnormal_sleep_pattern1.79144913
38MP0000372_irregular_coat_pigmentation1.77767851
39MP0009046_muscle_twitch1.76105255
40MP0004957_abnormal_blastocyst_morpholog1.74981545
41MP0000778_abnormal_nervous_system1.74542151
42MP0001984_abnormal_olfaction1.74043331
43MP0003136_yellow_coat_color1.73022590
44MP0005076_abnormal_cell_differentiation1.72249543
45MP0010678_abnormal_skin_adnexa1.68550412
46MP0005257_abnormal_intraocular_pressure1.68509482
47MP0002557_abnormal_social/conspecific_i1.68482557
48MP0004270_analgesia1.66056018
49MP0002064_seizures1.65982455
50MP0000383_abnormal_hair_follicle1.65511801
51MP0009703_decreased_birth_body1.65414379
52MP0008058_abnormal_DNA_repair1.64610964
53MP0001485_abnormal_pinna_reflex1.64575794
54MP0002734_abnormal_mechanical_nocicepti1.64153702
55MP0001440_abnormal_grooming_behavior1.62294038
56MP0002009_preneoplasia1.60302595
57MP0003941_abnormal_skin_development1.59074254
58MP0003879_abnormal_hair_cell1.57349441
59MP0001502_abnormal_circadian_rhythm1.56838770
60MP0003111_abnormal_nucleus_morphology1.56293144
61MP0002163_abnormal_gland_morphology1.55198240
62MP0003693_abnormal_embryo_hatching1.54230574
63MP0001529_abnormal_vocalization1.52096568
64MP0002272_abnormal_nervous_system1.51931113
65MP0005409_darkened_coat_color1.50902589
66MP0001177_atelectasis1.47941660
67MP0010352_gastrointestinal_tract_polyps1.45899780
68MP0002184_abnormal_innervation1.42007308
69MP0005551_abnormal_eye_electrophysiolog1.41346392
70MP0003077_abnormal_cell_cycle1.40811315
71MP0005075_abnormal_melanosome_morpholog1.37410920
72MP0001730_embryonic_growth_arrest1.37106850
73MP0002067_abnormal_sensory_capabilities1.35455313
74MP0000678_abnormal_parathyroid_gland1.33919131
75MP0001293_anophthalmia1.33558971
76MP0002102_abnormal_ear_morphology1.33346655
77MP0003119_abnormal_digestive_system1.30464526
78MP0001986_abnormal_taste_sensitivity1.26737012
79MP0001672_abnormal_embryogenesis/_devel1.25980356
80MP0005380_embryogenesis_phenotype1.25980356
81MP0002210_abnormal_sex_determination1.25536406
82MP0004197_abnormal_fetal_growth/weight/1.24148090
83MP0001970_abnormal_pain_threshold1.22889948
84MP0002084_abnormal_developmental_patter1.21052327
85MP0003718_maternal_effect1.20614413
86MP0003646_muscle_fatigue1.20572107
87MP0005310_abnormal_salivary_gland1.20167670
88MP0002938_white_spotting1.18533427
89MP0001929_abnormal_gametogenesis1.18205701
90MP0001963_abnormal_hearing_physiology1.17416708
91MP0004185_abnormal_adipocyte_glucose1.16850960
92MP0005666_abnormal_adipose_tissue1.13777647
93MP0001697_abnormal_embryo_size1.11988225
94MP0002088_abnormal_embryonic_growth/wei1.11905178
95MP0001286_abnormal_eye_development1.11014848
96MP0002638_abnormal_pupillary_reflex1.10607167
97MP0000015_abnormal_ear_pigmentation1.10282571
98MP0003984_embryonic_growth_retardation1.10175392
99MP0000631_abnormal_neuroendocrine_gland1.10008652
100MP0004484_altered_response_of1.09918446
101MP0000579_abnormal_nail_morphology1.08975742
102MP0003698_abnormal_male_reproductive1.08170481
103MP0004924_abnormal_behavior1.07735833
104MP0005386_behavior/neurological_phenoty1.07735833
105MP0003122_maternal_imprinting1.07333708
106MP0003861_abnormal_nervous_system1.07219119
107MP0000428_abnormal_craniofacial_morphol1.06822685
108MP0004858_abnormal_nervous_system1.06143049
109MP0002085_abnormal_embryonic_tissue1.05113410
110MP0003121_genomic_imprinting1.04795582
111MP0001145_abnormal_male_reproductive1.04101169
112MP0003221_abnormal_cardiomyocyte_apopto1.03442297
113MP0002095_abnormal_skin_pigmentation0.99866453
114MP0009250_abnormal_appendicular_skeleto0.98769093
115MP0002090_abnormal_vision0.98579402
116MP0000371_diluted_coat_color0.97510489
117MP0004510_myositis0.96089751
118MP0002733_abnormal_thermal_nociception0.95316972
119MP0003453_abnormal_keratinocyte_physiol0.95104187
120MP0008932_abnormal_embryonic_tissue0.94204792
121MP0000026_abnormal_inner_ear0.93547316
122MP0000653_abnormal_sex_gland0.92715405
123MP0004381_abnormal_hair_follicle0.92158369
124MP0000350_abnormal_cell_proliferation0.91979998
125MP0002697_abnormal_eye_size0.91174472
126MP0010307_abnormal_tumor_latency0.91088809
127MP0005394_taste/olfaction_phenotype0.90738561
128MP0005499_abnormal_olfactory_system0.90738561
129MP0003938_abnormal_ear_development0.90487649
130MP0008789_abnormal_olfactory_epithelium0.90301849
131MP0002882_abnormal_neuron_morphology0.90062124
132MP0003890_abnormal_embryonic-extraembry0.88819234
133MP0005174_abnormal_tail_pigmentation0.88445422
134MP0000613_abnormal_salivary_gland0.88358706
135MP0001324_abnormal_eye_pigmentation0.87243428
136MP0003755_abnormal_palate_morphology0.86624649
137MP0003868_abnormal_feces_composition0.86134318
138MP0000049_abnormal_middle_ear0.85988074
139MP0005367_renal/urinary_system_phenotyp0.85557404
140MP0000516_abnormal_urinary_system0.85557404
141MP0004885_abnormal_endolymph0.85504937
142MP0003690_abnormal_glial_cell0.81891967
143MP0000681_abnormal_thyroid_gland0.81536380
144MP0004811_abnormal_neuron_physiology0.81235062
145MP0005647_abnormal_sex_gland0.81157312
146MP0000647_abnormal_sebaceous_gland0.80921386
147MP0002086_abnormal_extraembryonic_tissu0.80083106
148MP0002752_abnormal_somatic_nervous0.79962905
149MP0002066_abnormal_motor_capabilities/c0.79269069
150MP0002111_abnormal_tail_morphology0.79082707
151MP0000955_abnormal_spinal_cord0.78812016
152MP0005248_abnormal_Harderian_gland0.78565230
153MP0010386_abnormal_urinary_bladder0.77488032
154MP0005275_abnormal_skin_tensile0.77207880
155MP0002139_abnormal_hepatobiliary_system0.76900097
156MP0005379_endocrine/exocrine_gland_phen0.75042421
157MP0003385_abnormal_body_wall0.74467204
158MP0002233_abnormal_nose_morphology0.72793484
159MP0008995_early_reproductive_senescence0.71941640
160MP0002249_abnormal_larynx_morphology0.69418925
161MP0003937_abnormal_limbs/digits/tail_de0.68725407
162MP0005253_abnormal_eye_physiology0.67764470
163MP0001299_abnormal_eye_distance/0.67740775
164MP0002116_abnormal_craniofacial_bone0.67303822
165MP0002152_abnormal_brain_morphology0.66499596

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)4.62256154
2Focal motor seizures (HP:0011153)4.40615675
3Parakeratosis (HP:0001036)4.15432770
4Absent eyebrow (HP:0002223)4.00633477
5Hepatoblastoma (HP:0002884)3.71628239
6Unilateral renal agenesis (HP:0000122)3.64834895
7Abnormality of the labia minora (HP:0012880)3.64038054
8Aplasia/Hypoplasia of the sternum (HP:0006714)3.52804745
9Papillary thyroid carcinoma (HP:0002895)3.51961170
10Congenital sensorineural hearing impairment (HP:0008527)3.27783653
11Cortical dysplasia (HP:0002539)3.24646922
12Septo-optic dysplasia (HP:0100842)3.10896950
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.10819784
14Epileptic encephalopathy (HP:0200134)3.08479966
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.06238863
16Absent/shortened dynein arms (HP:0200106)3.06238863
17Rhabdomyosarcoma (HP:0002859)3.02525640
18Abnormal lung lobation (HP:0002101)3.00854646
19Hypoplastic labia majora (HP:0000059)2.93013318
20Chromsome breakage (HP:0040012)2.89181272
21Nephroblastoma (Wilms tumor) (HP:0002667)2.87482253
22Abnormality of dental color (HP:0011073)2.85859885
23Cheilitis (HP:0100825)2.84712603
24Embryonal renal neoplasm (HP:0011794)2.79850774
25Colon cancer (HP:0003003)2.74934865
26Increased nuchal translucency (HP:0010880)2.72671597
27Abnormality of incisor morphology (HP:0011063)2.70352687
28Gonadotropin excess (HP:0000837)2.67139842
29Follicular hyperkeratosis (HP:0007502)2.66455763
30Bilateral sensorineural hearing impairment (HP:0008619)2.60490603
31Ectopic kidney (HP:0000086)2.60177577
32Protruding tongue (HP:0010808)2.57659803
33Prostate neoplasm (HP:0100787)2.57346986
34Abnormality of the labia majora (HP:0012881)2.56832214
35Neoplasm of the oral cavity (HP:0100649)2.56386305
36Medulloblastoma (HP:0002885)2.53537541
37Abnormal ciliary motility (HP:0012262)2.52226263
38Focal seizures (HP:0007359)2.51581455
39Absent speech (HP:0001344)2.47270188
40Labial hypoplasia (HP:0000066)2.46254040
41Absent eyelashes (HP:0000561)2.41338050
42Abnormality of the salivary glands (HP:0010286)2.40825300
43Megalencephaly (HP:0001355)2.40750731
44Transitional cell carcinoma of the bladder (HP:0006740)2.38778400
45White forelock (HP:0002211)2.38721064
46Gastrointestinal carcinoma (HP:0002672)2.37445522
47Malignant gastrointestinal tract tumors (HP:0006749)2.37445522
48Widely spaced teeth (HP:0000687)2.36403457
49Aplasia cutis congenita (HP:0001057)2.34483450
50Choanal stenosis (HP:0000452)2.34044725
51Alopecia of scalp (HP:0002293)2.33981305
52Oligodontia (HP:0000677)2.29952819
532-3 toe syndactyly (HP:0004691)2.29893156
54Uterine leiomyosarcoma (HP:0002891)2.29772079
55Leiomyosarcoma (HP:0100243)2.29772079
56Hyperventilation (HP:0002883)2.25088919
57Hypoplastic female external genitalia (HP:0012815)2.24703755
58Recurrent corneal erosions (HP:0000495)2.24646831
59Dyschromatopsia (HP:0007641)2.23768726
60Patchy hypopigmentation of hair (HP:0011365)2.23696283
61Embryonal neoplasm (HP:0002898)2.22605898
62Ulnar claw (HP:0001178)2.22088828
63Neoplasm of striated muscle (HP:0009728)2.21790940
64Midline defect of the nose (HP:0004122)2.21652943
65Congenital stationary night blindness (HP:0007642)2.20783528
66Thickened helices (HP:0000391)2.20133391
67Bladder neoplasm (HP:0009725)2.18863088
68Bladder carcinoma (HP:0002862)2.18863088
69Facial hemangioma (HP:0000329)2.18565387
70Chronic hepatic failure (HP:0100626)2.18361108
71Abnormal hair whorl (HP:0010721)2.14233797
72Alveolar cell carcinoma (HP:0006519)2.13896434
73Neoplasm of the tracheobronchial system (HP:0100552)2.13706681
74Lip pit (HP:0100267)2.13301320
75Decreased central vision (HP:0007663)2.12871749
76Abnormality of the renal collecting system (HP:0004742)2.12614000
77Hyperphosphatemia (HP:0002905)2.11796062
78Supernumerary spleens (HP:0009799)2.10242551
79Aplasia involving bones of the extremities (HP:0009825)2.09712812
80Aplasia involving bones of the upper limbs (HP:0009823)2.09712812
81Aplasia of the phalanges of the hand (HP:0009802)2.09712812
82Small hand (HP:0200055)2.09557596
83Broad-based gait (HP:0002136)2.09188232
84Inappropriate behavior (HP:0000719)2.09123861
85Impaired vibration sensation in the lower limbs (HP:0002166)2.08692543
86Cutaneous finger syndactyly (HP:0010554)2.08332033
87Drooling (HP:0002307)2.07054756
88Excessive salivation (HP:0003781)2.07054756
89Vertebral arch anomaly (HP:0008438)2.07022610
90Aqueductal stenosis (HP:0002410)2.05861602
91Osteomalacia (HP:0002749)2.03680144
92Abnormality of chromosome segregation (HP:0002916)2.03061393
93Progressive cerebellar ataxia (HP:0002073)2.02889066
94Short middle phalanx of the 5th finger (HP:0004220)2.02624004
95Duplicated collecting system (HP:0000081)2.02419289
96Thyroid carcinoma (HP:0002890)1.99693656
97Fetal akinesia sequence (HP:0001989)1.97875630
98Absent septum pellucidum (HP:0001331)1.96540157
99Generalized hypopigmentation of hair (HP:0011358)1.95202898
100Abnormality of the nasal septum (HP:0000419)1.95037653
101Abnormality of the pubic bones (HP:0003172)1.94528253
102Increased number of teeth (HP:0011069)1.91751137
103Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90785490
104Amyotrophic lateral sclerosis (HP:0007354)1.90763274
105Conical tooth (HP:0000698)1.90672983
106Renal dysplasia (HP:0000110)1.87721128
107Neoplasm of the small intestine (HP:0100833)1.87268611
108Curly hair (HP:0002212)1.86854777
109Depressed nasal tip (HP:0000437)1.86212977
110Truncal obesity (HP:0001956)1.84848387
111Abnormality of the dental root (HP:0006486)1.83764956
112Taurodontia (HP:0000679)1.83764956
113Abnormality of permanent molar morphology (HP:0011071)1.83764956
114Abnormal respiratory motile cilium morphology (HP:0005938)1.83682819
115Abnormal respiratory epithelium morphology (HP:0012253)1.83682819
116Rimmed vacuoles (HP:0003805)1.83633857
117Abnormality of the lower motor neuron (HP:0002366)1.83269600
118Generalized tonic-clonic seizures (HP:0002069)1.82893060
119Impulsivity (HP:0100710)1.82250459
120Abnormal respiratory motile cilium physiology (HP:0012261)1.82136596
121Dysdiadochokinesis (HP:0002075)1.81604056
122Obsessive-compulsive behavior (HP:0000722)1.81012136
123Hip dysplasia (HP:0001385)1.80799096
124Cupped ear (HP:0000378)1.80689491
125Small epiphyses (HP:0010585)1.80469626
126Intestinal atresia (HP:0011100)1.80398790
127Fair hair (HP:0002286)1.80148569
128Abnormality of the intervertebral disk (HP:0005108)1.79905067
129Optic nerve hypoplasia (HP:0000609)1.79319595
130Turricephaly (HP:0000262)1.78122943
131Ectropion (HP:0000656)1.77576291
132Menstrual irregularities (HP:0000858)1.77240765
133Blue irides (HP:0000635)1.76988174
134Broad alveolar ridges (HP:0000187)1.75325897
135Abolished electroretinogram (ERG) (HP:0000550)1.75228112
136Skull defect (HP:0001362)1.74899971
137Cutaneous syndactyly (HP:0012725)1.74731490
138Abnormality of the septum pellucidum (HP:0007375)1.74525041
139Absent hair (HP:0002298)1.73712579
140Heterotopia (HP:0002282)1.73412150
141Oligodactyly (hands) (HP:0001180)1.72680290
142Oligodactyly (HP:0012165)1.72377271
143Gastroesophageal reflux (HP:0002020)1.70767203
144Absent radius (HP:0003974)1.70153519
145Decreased lacrimation (HP:0000633)1.70104721
146Atonic seizures (HP:0010819)1.69989799
147Erythroderma (HP:0001019)1.68907857
148Genetic anticipation (HP:0003743)1.68686443
149Biliary tract neoplasm (HP:0100574)1.67632700
150Germ cell neoplasia (HP:0100728)1.66622181
151Sensory axonal neuropathy (HP:0003390)1.65860330
152Dialeptic seizures (HP:0011146)1.65858079
153Alacrima (HP:0000522)1.65616783
154Shoulder girdle muscle weakness (HP:0003547)1.64158818
155Abnormality of the labia (HP:0000058)1.63074225
156Volvulus (HP:0002580)1.62550352
157Absence seizures (HP:0002121)1.62370030
158Neoplasm of the lung (HP:0100526)1.62321277
159Uterine neoplasm (HP:0010784)1.62089594
160Myelomeningocele (HP:0002475)1.61802924
161Non-midline cleft lip (HP:0100335)1.61499613
162Omphalocele (HP:0001539)1.61462144
163Hypoplastic iliac wings (HP:0002866)1.61352185
164Abnormality of chromosome stability (HP:0003220)1.60479497
165Peripheral hypomyelination (HP:0007182)1.60415535
166Generalized hypotonia (HP:0001290)1.59650415
167Urinary bladder sphincter dysfunction (HP:0002839)1.56440274
168Poor eye contact (HP:0000817)1.55972126
169Gaze-evoked nystagmus (HP:0000640)1.55476834
170Anomalous pulmonary venous return (HP:0010772)1.54901894
171Myokymia (HP:0002411)1.53953375
172Tented upper lip vermilion (HP:0010804)1.53746016
173Preauricular pit (HP:0004467)1.52609739
174Periauricular skin pits (HP:0100277)1.52609739
175Hypoplasia of the capital femoral epiphysis (HP:0003090)1.52600572
176Primary atrial arrhythmia (HP:0001692)1.50012247
177Abnormality of the right ventricle (HP:0001707)1.48516820
178Abnormality of salivation (HP:0100755)1.47785074
179Nephrogenic diabetes insipidus (HP:0009806)1.47108130
180Hypocalcemia (HP:0002901)1.46197307
181Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.46036771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.31413032
2SIK23.43651397
3CASK3.15442812
4NTRK32.87992673
5TNIK2.67021701
6CDK82.50164508
7EPHA42.37544535
8MAP2K72.36908650
9STK242.31128751
10TTK2.26340959
11PLK42.21549349
12LATS12.03689351
13MAP3K42.01865790
14MAPK131.98270603
15MARK11.91278386
16RIPK41.87633958
17WEE11.86228249
18MAP3K101.83131131
19EEF2K1.78593820
20STK38L1.70045726
21EIF2AK31.67272742
22FGFR11.62833285
23SIK11.61478885
24PLK21.61055983
25TYRO31.59474374
26MARK31.55029987
27LATS21.53022976
28FGFR21.52951090
29PRPF4B1.52781085
30NLK1.47706446
31BMPR21.46431529
32TSSK61.41828073
33ACVR1B1.41130202
34BMPR1B1.40114185
35CDK121.39321226
36CDC71.33144787
37TAF11.31674329
38BRD41.27038742
39MAP3K121.24885351
40TRIM281.24511151
41SGK21.24492389
42CDK31.23790939
43BRSK21.22038641
44MAP2K41.21378386
45CDK61.13817938
46AKT31.12454422
47NEK11.10226673
48NTRK21.08290554
49MKNK21.08273383
50DMPK1.06276451
51TXK1.05602557
52MAP3K61.02915772
53GRK71.00370812
54WNK30.99669807
55INSRR0.98281201
56MINK10.95584726
57ALK0.91038842
58BRAF0.88130072
59ZAK0.87208892
60IRAK10.86022778
61TGFBR10.85743290
62DYRK30.85659477
63ADRBK20.85113254
64SGK4940.83491863
65SGK2230.83491863
66SGK10.82631216
67CAMK1G0.81587997
68SGK30.81165672
69ATM0.80754241
70MAP3K130.80041854
71NUAK10.78083224
72WNK10.75659928
73PBK0.74978006
74RPS6KB10.74487962
75BCR0.73973547
76PLK10.73728669
77CHEK20.73236691
78TAOK20.72985787
79STK30.72572178
80STK380.72392381
81FGFR30.71392031
82FGR0.71039744
83STK110.70918544
84EPHA30.70312496
85YES10.70210799
86TNK20.69873265
87EIF2AK20.68634564
88NEK60.68313721
89DYRK1A0.68034378
90IRAK20.67967491
91CAMK10.67168340
92DYRK20.66716265
93MAP3K140.66317765
94CAMK2A0.66119823
95MARK20.65727267
96DAPK20.64403183
97CAMK1D0.60617251
98PKN10.58615660
99MAP3K90.58246244
100ERBB40.57485930
101GRK50.57405925
102PRKCE0.57296559
103CAMK40.56970333
104PDGFRB0.56009186
105FES0.55752594
106OBSCN0.55627834
107CSNK1D0.55251538
108CDK50.54668239
109MELK0.54642674
110EPHB20.54595230
111TAOK30.54520298
112CHEK10.52860499
113NEK20.51184762
114PNCK0.49888769
115KSR10.49604938
116ERBB30.49481191
117CSNK1E0.48692862
118CDK10.48506252
119MAPK100.45927142
120PINK10.45866941
121NEK90.45626183
122PRKG10.45566657
123MAP3K50.44934268
124PAK60.42362900
125EPHA20.41533042
126ATR0.40301929
127CDK20.40152828
128CSNK1G10.39723885
129PDGFRA0.39657654
130MOS0.39378349
131PRKDC0.39301919
132CSNK1G20.38556501
133MKNK10.38057182
134CDK40.37860587
135CDK180.37564033
136GSK3B0.37063913
137TEC0.36970899
138PLK30.34369821
139PRKAA20.34311548
140PRKCG0.34138573
141SRPK10.33610254
142MAPK140.31644407
143CSNK1A1L0.30694122
144CDK70.29618286
145CLK10.29238813
146IRAK40.28678329
147CSNK1A10.28415607
148CDK190.28207551
149GRK10.27412732

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.35938446
2Steroid biosynthesis_Homo sapiens_hsa001002.81890710
3Non-homologous end-joining_Homo sapiens_hsa034502.76924160
4Cell cycle_Homo sapiens_hsa041102.27425310
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.17516979
6mRNA surveillance pathway_Homo sapiens_hsa030151.97764092
7Morphine addiction_Homo sapiens_hsa050321.97182108
8Phototransduction_Homo sapiens_hsa047441.97001553
9Oocyte meiosis_Homo sapiens_hsa041141.89828490
10Glutamatergic synapse_Homo sapiens_hsa047241.86855039
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85573781
12Circadian entrainment_Homo sapiens_hsa047131.84602941
13Fatty acid biosynthesis_Homo sapiens_hsa000611.74826880
14Serotonergic synapse_Homo sapiens_hsa047261.73655780
15Olfactory transduction_Homo sapiens_hsa047401.72290725
16Synaptic vesicle cycle_Homo sapiens_hsa047211.70619676
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.69213137
18RNA transport_Homo sapiens_hsa030131.66584867
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63162705
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62291245
21Axon guidance_Homo sapiens_hsa043601.61702493
22Long-term potentiation_Homo sapiens_hsa047201.57736675
23Circadian rhythm_Homo sapiens_hsa047101.57030024
24Colorectal cancer_Homo sapiens_hsa052101.55832252
25Taste transduction_Homo sapiens_hsa047421.55319815
26Calcium signaling pathway_Homo sapiens_hsa040201.54928857
27GABAergic synapse_Homo sapiens_hsa047271.50383075
28Propanoate metabolism_Homo sapiens_hsa006401.44548444
29Long-term depression_Homo sapiens_hsa047301.43931160
30RNA degradation_Homo sapiens_hsa030181.41116875
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40845191
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40082276
33Salivary secretion_Homo sapiens_hsa049701.38446358
34Amphetamine addiction_Homo sapiens_hsa050311.33712422
35Cholinergic synapse_Homo sapiens_hsa047251.33689922
36Renin secretion_Homo sapiens_hsa049241.33258939
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.31878727
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29946277
39Dopaminergic synapse_Homo sapiens_hsa047281.25245160
40Mismatch repair_Homo sapiens_hsa034301.24124999
41Oxytocin signaling pathway_Homo sapiens_hsa049211.21094636
42ErbB signaling pathway_Homo sapiens_hsa040121.20823004
43Thyroid cancer_Homo sapiens_hsa052161.19757489
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17119715
45TGF-beta signaling pathway_Homo sapiens_hsa043501.15196354
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13274406
47Inositol phosphate metabolism_Homo sapiens_hsa005621.11811907
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11226878
49cAMP signaling pathway_Homo sapiens_hsa040241.10240021
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09233290
51Insulin secretion_Homo sapiens_hsa049111.08812677
52Type II diabetes mellitus_Homo sapiens_hsa049301.08730977
53Fatty acid metabolism_Homo sapiens_hsa012121.07305991
54GnRH signaling pathway_Homo sapiens_hsa049121.03590624
55Choline metabolism in cancer_Homo sapiens_hsa052311.03396897
56Melanoma_Homo sapiens_hsa052181.03274942
57Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03081618
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02455824
59Spliceosome_Homo sapiens_hsa030401.02244844
60Collecting duct acid secretion_Homo sapiens_hsa049661.00960458
61Wnt signaling pathway_Homo sapiens_hsa043100.99351356
62Lysine degradation_Homo sapiens_hsa003100.98559829
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97994134
64Cocaine addiction_Homo sapiens_hsa050300.97256664
65Glucagon signaling pathway_Homo sapiens_hsa049220.95680212
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95196684
67Ras signaling pathway_Homo sapiens_hsa040140.94746150
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94393194
69Tight junction_Homo sapiens_hsa045300.94055180
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93967417
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93292635
72Insulin signaling pathway_Homo sapiens_hsa049100.93143803
73Mineral absorption_Homo sapiens_hsa049780.92952681
74Glioma_Homo sapiens_hsa052140.92829968
75MAPK signaling pathway_Homo sapiens_hsa040100.91726973
76Ovarian steroidogenesis_Homo sapiens_hsa049130.90478386
77Hedgehog signaling pathway_Homo sapiens_hsa043400.90384717
78Rheumatoid arthritis_Homo sapiens_hsa053230.89995562
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89885076
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87378227
81Dorso-ventral axis formation_Homo sapiens_hsa043200.87313878
82Pyruvate metabolism_Homo sapiens_hsa006200.87033966
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86623073
84Autoimmune thyroid disease_Homo sapiens_hsa053200.84905387
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84275441
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84107031
87African trypanosomiasis_Homo sapiens_hsa051430.82878208
88Gastric acid secretion_Homo sapiens_hsa049710.82576254
89Melanogenesis_Homo sapiens_hsa049160.81074568
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80121548
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79833865
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.79404122
93Basal transcription factors_Homo sapiens_hsa030220.79326975
94Renal cell carcinoma_Homo sapiens_hsa052110.79267780
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77045012
96VEGF signaling pathway_Homo sapiens_hsa043700.76579038
97Chronic myeloid leukemia_Homo sapiens_hsa052200.75768387
98Osteoclast differentiation_Homo sapiens_hsa043800.75492677
99Asthma_Homo sapiens_hsa053100.74864304
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.71069048
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70685776
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.68772200
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.68519844
104Prolactin signaling pathway_Homo sapiens_hsa049170.68394693
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68207729
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68113497
107Tuberculosis_Homo sapiens_hsa051520.67933734
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67518936
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67495860
110AMPK signaling pathway_Homo sapiens_hsa041520.66839553
111Rap1 signaling pathway_Homo sapiens_hsa040150.66684556
112FoxO signaling pathway_Homo sapiens_hsa040680.65631825
113p53 signaling pathway_Homo sapiens_hsa041150.63657729
114TNF signaling pathway_Homo sapiens_hsa046680.63536867
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62968492
116Estrogen signaling pathway_Homo sapiens_hsa049150.62742880
117Sphingolipid metabolism_Homo sapiens_hsa006000.62242355
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.61754590
119Ether lipid metabolism_Homo sapiens_hsa005650.61515385
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61232719
121Non-small cell lung cancer_Homo sapiens_hsa052230.60779158
122Fanconi anemia pathway_Homo sapiens_hsa034600.60395509
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.60140240
124Gap junction_Homo sapiens_hsa045400.59894605
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59642095
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59516523
127Endometrial cancer_Homo sapiens_hsa052130.58749285
128Chemokine signaling pathway_Homo sapiens_hsa040620.58478022
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58393902
130T cell receptor signaling pathway_Homo sapiens_hsa046600.57682400
131Dilated cardiomyopathy_Homo sapiens_hsa054140.57316128
132Acute myeloid leukemia_Homo sapiens_hsa052210.57292680
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.56397093
134Pancreatic cancer_Homo sapiens_hsa052120.55672179
135MicroRNAs in cancer_Homo sapiens_hsa052060.55458377
136Hippo signaling pathway_Homo sapiens_hsa043900.54953666
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53926249
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53897088
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53357413
140mTOR signaling pathway_Homo sapiens_hsa041500.53055669
141Proteoglycans in cancer_Homo sapiens_hsa052050.52468204
142Prostate cancer_Homo sapiens_hsa052150.52260241
143DNA replication_Homo sapiens_hsa030300.51608103
144Homologous recombination_Homo sapiens_hsa034400.51601304
145Adherens junction_Homo sapiens_hsa045200.51518134
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51178455
147Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51095332
148Basal cell carcinoma_Homo sapiens_hsa052170.51047225
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.50854734
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50844048
151Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47818095
152Pathways in cancer_Homo sapiens_hsa052000.47019366
153Notch signaling pathway_Homo sapiens_hsa043300.45126936
154Hepatitis B_Homo sapiens_hsa051610.44863402
155B cell receptor signaling pathway_Homo sapiens_hsa046620.44544186

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