LONRF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.23785463
2synaptic vesicle maturation (GO:0016188)5.80111725
3vocalization behavior (GO:0071625)5.69483678
4locomotory exploration behavior (GO:0035641)5.50972117
5synaptic vesicle exocytosis (GO:0016079)5.46643427
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.46430686
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.42972425
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.21347970
9regulation of synaptic vesicle exocytosis (GO:2000300)5.15122904
10glutamate secretion (GO:0014047)5.09268377
11neuron cell-cell adhesion (GO:0007158)5.02905176
12regulation of glutamate receptor signaling pathway (GO:1900449)4.93147290
13protein localization to synapse (GO:0035418)4.90234614
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.76910457
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.70341008
16neurotransmitter secretion (GO:0007269)4.62112231
17exploration behavior (GO:0035640)4.58904156
18regulation of synaptic vesicle transport (GO:1902803)4.58287587
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.42624818
20layer formation in cerebral cortex (GO:0021819)4.30776689
21neurotransmitter-gated ion channel clustering (GO:0072578)4.23773667
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.23730580
23glutamate receptor signaling pathway (GO:0007215)4.23618697
24synaptic transmission, glutamatergic (GO:0035249)4.21456104
25regulation of neuronal synaptic plasticity (GO:0048168)4.19860786
26gamma-aminobutyric acid transport (GO:0015812)4.13568195
27neuronal action potential propagation (GO:0019227)4.11494140
28regulation of synapse structural plasticity (GO:0051823)4.10177325
29proline transport (GO:0015824)4.05705084
30neuron-neuron synaptic transmission (GO:0007270)4.04873796
31dendritic spine morphogenesis (GO:0060997)4.01555934
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.91466143
33neuron recognition (GO:0008038)3.85710292
34L-amino acid import (GO:0043092)3.84805780
35potassium ion homeostasis (GO:0055075)3.81586178
36cellular sodium ion homeostasis (GO:0006883)3.79795760
37postsynaptic membrane organization (GO:0001941)3.79378204
38neurotransmitter transport (GO:0006836)3.79068943
39long-term memory (GO:0007616)3.76064875
40positive regulation of synapse maturation (GO:0090129)3.72082404
41positive regulation of synaptic transmission, GABAergic (GO:0032230)3.69382619
42positive regulation of membrane potential (GO:0045838)3.67850328
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67602229
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64924600
45synaptic vesicle endocytosis (GO:0048488)3.62737468
46cellular potassium ion homeostasis (GO:0030007)3.59083020
47potassium ion import (GO:0010107)3.56909418
48activation of protein kinase A activity (GO:0034199)3.56117634
49regulation of postsynaptic membrane potential (GO:0060078)3.55192982
50presynaptic membrane assembly (GO:0097105)3.51527312
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.50957337
52gamma-aminobutyric acid signaling pathway (GO:0007214)3.49533101
53neuronal ion channel clustering (GO:0045161)3.49075778
54axonal fasciculation (GO:0007413)3.46419281
55regulation of neurotransmitter levels (GO:0001505)3.45371595
56cerebellar Purkinje cell differentiation (GO:0021702)3.41440302
57transmission of nerve impulse (GO:0019226)3.40574191
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.40507097
59regulation of neurotransmitter secretion (GO:0046928)3.39058966
60dendrite morphogenesis (GO:0048813)3.38602315
61negative regulation of dendrite morphogenesis (GO:0050774)3.37340771
62regulation of synaptic plasticity (GO:0048167)3.36195238
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.35772364
64auditory behavior (GO:0031223)3.32916981
65negative regulation of cytosolic calcium ion concentration (GO:0051481)3.32521232
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.32044353
67neuromuscular process controlling posture (GO:0050884)3.31913229
68amino acid import (GO:0043090)3.29936447
69cell communication involved in cardiac conduction (GO:0086065)3.29748294
70long-term synaptic potentiation (GO:0060291)3.29686635
71regulation of voltage-gated calcium channel activity (GO:1901385)3.29384096
72synapse assembly (GO:0007416)3.28616157
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28034899
74presynaptic membrane organization (GO:0097090)3.27645152
75cell migration in hindbrain (GO:0021535)3.26119492
76positive regulation of dendritic spine development (GO:0060999)3.24981817
77G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24936284
78regulation of vesicle fusion (GO:0031338)3.24685895
79regulation of dendritic spine morphogenesis (GO:0061001)3.23691240
80neuromuscular process controlling balance (GO:0050885)3.22975676
81response to histamine (GO:0034776)3.22921042
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21773566
83response to auditory stimulus (GO:0010996)3.20125431
84membrane hyperpolarization (GO:0060081)3.18311582
85sodium ion export (GO:0071436)3.17698939
86innervation (GO:0060384)3.16219644
87vesicle transport along microtubule (GO:0047496)3.16037358
88cerebellar granule cell differentiation (GO:0021707)3.16003925
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.14894827
90axon ensheathment in central nervous system (GO:0032291)3.13268671
91central nervous system myelination (GO:0022010)3.13268671
92regulation of neurotransmitter transport (GO:0051588)3.13232716
93membrane depolarization during action potential (GO:0086010)3.13149873
94detection of calcium ion (GO:0005513)3.11141546
95prepulse inhibition (GO:0060134)3.09338991
96membrane depolarization (GO:0051899)3.07772369
97regulation of synaptic transmission, GABAergic (GO:0032228)3.07666276
98learning (GO:0007612)3.05130033
99startle response (GO:0001964)3.04170530
100social behavior (GO:0035176)3.03733138
101intraspecies interaction between organisms (GO:0051703)3.03733138
102cell communication by electrical coupling (GO:0010644)3.03223906
103behavioral defense response (GO:0002209)3.02180742
104behavioral fear response (GO:0001662)3.02180742
105positive regulation of neurotransmitter transport (GO:0051590)3.01577846
106regulation of dendritic spine development (GO:0060998)3.01250342
107organelle transport along microtubule (GO:0072384)3.00763019
108regulation of ARF protein signal transduction (GO:0032012)2.99890297
109regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.99537104
110positive regulation of neurotransmitter secretion (GO:0001956)2.99395488
111synaptic transmission (GO:0007268)2.98823005
112regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97927305
113positive regulation of synaptic transmission (GO:0050806)2.96865084
114neuromuscular synaptic transmission (GO:0007274)2.96844035
115glycine transport (GO:0015816)2.95129216
116regulation of synaptic transmission (GO:0050804)2.93937222
117regulation of synapse maturation (GO:0090128)2.93745480
118synapse organization (GO:0050808)2.93664118
119positive regulation of dendritic spine morphogenesis (GO:0061003)2.88614165
120positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.84524010
121neurotransmitter uptake (GO:0001504)2.84216202
122serotonin metabolic process (GO:0042428)2.84005285
123neuromuscular process (GO:0050905)2.82908092
124positive regulation of potassium ion transmembrane transport (GO:1901381)2.80766944
125cochlea development (GO:0090102)2.80438520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.07631281
2GBX2_23144817_ChIP-Seq_PC3_Human3.81474314
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07908052
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00988224
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97364171
6REST_21632747_ChIP-Seq_MESCs_Mouse2.78259907
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61958009
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61958009
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57718354
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51965976
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.51445422
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46764033
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45467693
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42891663
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41008870
16DROSHA_22980978_ChIP-Seq_HELA_Human2.38788724
17* RARB_27405468_Chip-Seq_BRAIN_Mouse2.38692403
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32801528
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.25311306
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24254751
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22461412
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.22231574
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.21023196
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18752047
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.11817215
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04892907
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97265568
28AR_21572438_ChIP-Seq_LNCaP_Human1.96608836
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94474504
30TAF15_26573619_Chip-Seq_HEK293_Human1.90541658
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76259410
32SMAD4_21799915_ChIP-Seq_A2780_Human1.75625631
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71925499
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70127646
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69221383
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60259423
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52936353
38ZNF274_21170338_ChIP-Seq_K562_Hela1.51569784
39P300_19829295_ChIP-Seq_ESCs_Human1.48643058
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.43680725
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43227948
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40158859
43* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37945235
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.34948937
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.33783581
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32842961
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32515195
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.32443763
49AR_25329375_ChIP-Seq_VCAP_Human1.31505188
50IGF1R_20145208_ChIP-Seq_DFB_Human1.31446107
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31057674
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29706479
53STAT3_23295773_ChIP-Seq_U87_Human1.29484840
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28938298
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27458498
56* RING1B_27294783_Chip-Seq_ESCs_Mouse1.27295268
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26033446
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25337903
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23936382
60* AR_19668381_ChIP-Seq_PC3_Human1.23707555
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22413237
62* RNF2_27304074_Chip-Seq_NSC_Mouse1.20470062
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.19997090
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18657759
65* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18186408
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14393941
67* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14317173
68TCF4_23295773_ChIP-Seq_U87_Human1.13222395
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12458034
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12325952
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.12285989
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11148617
73YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09740395
74AHR_22903824_ChIP-Seq_MCF-7_Human1.09264462
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08976002
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07819964
77* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07576017
78* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06730718
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05946672
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05054896
81FUS_26573619_Chip-Seq_HEK293_Human1.03551102
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02996839
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02943641
84* RUNX2_22187159_ChIP-Seq_PCA_Human1.02473375
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00753122
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.00358754
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00018234
88SMAD3_21741376_ChIP-Seq_ESCs_Human0.97638612
89ESR2_21235772_ChIP-Seq_MCF-7_Human0.97498472
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96997194
91SMAD3_21741376_ChIP-Seq_HESCs_Human0.96671538
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96320497
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95835998
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95125982
95JUN_21703547_ChIP-Seq_K562_Human0.94878789
96EP300_21415370_ChIP-Seq_HL-1_Mouse0.94215601
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93796922
98KDM2B_26808549_Chip-Seq_K562_Human0.93729172
99ER_23166858_ChIP-Seq_MCF-7_Human0.93271862
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.93245809
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92658352
102ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91859368
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91766910
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91766910
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91483344
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91000409
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90389823
108EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89574334
109TP53_16413492_ChIP-PET_HCT116_Human0.88844471
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88829445
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88785236
112* NANOG_18555785_Chip-Seq_ESCs_Mouse0.88276946
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88100815
114KDM2B_26808549_Chip-Seq_REH_Human0.88055629
115* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88020395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.05899794
2MP0003880_abnormal_central_pattern4.73578697
3MP0003635_abnormal_synaptic_transmissio4.10524190
4MP0004270_analgesia3.70559791
5MP0009745_abnormal_behavioral_response3.35744840
6MP0002063_abnormal_learning/memory/cond3.29683872
7MP0009046_muscle_twitch3.25827960
8MP0005423_abnormal_somatic_nervous3.15877191
9MP0001968_abnormal_touch/_nociception3.15132336
10MP0002064_seizures3.13262185
11MP0002572_abnormal_emotion/affect_behav2.82828172
12MP0002734_abnormal_mechanical_nocicepti2.73972131
13MP0002272_abnormal_nervous_system2.58765144
14MP0002822_catalepsy2.55586767
15MP0001486_abnormal_startle_reflex2.48789184
16MP0002735_abnormal_chemical_nociception2.46042769
17MP0002736_abnormal_nociception_after2.37061034
18MP0001501_abnormal_sleep_pattern2.20514271
19MP0002733_abnormal_thermal_nociception2.14790661
20MP0001440_abnormal_grooming_behavior2.11953996
21MP0002067_abnormal_sensory_capabilities2.04064018
22MP0006276_abnormal_autonomic_nervous2.03503825
23MP0001970_abnormal_pain_threshold1.99781840
24MP0000778_abnormal_nervous_system1.98152951
25MP0002184_abnormal_innervation1.96472031
26MP0002557_abnormal_social/conspecific_i1.85129096
27MP0009780_abnormal_chondrocyte_physiolo1.84917848
28MP0004924_abnormal_behavior1.83669040
29MP0005386_behavior/neurological_phenoty1.83669040
30MP0004811_abnormal_neuron_physiology1.81534595
31MP0003787_abnormal_imprinting1.81159190
32MP0008569_lethality_at_weaning1.80321621
33MP0005646_abnormal_pituitary_gland1.77095387
34MP0003122_maternal_imprinting1.76993696
35MP0004858_abnormal_nervous_system1.74849233
36MP0005645_abnormal_hypothalamus_physiol1.71841859
37MP0001984_abnormal_olfaction1.70701467
38MP0002909_abnormal_adrenal_gland1.64932349
39MP0003329_amyloid_beta_deposits1.62108579
40MP0000955_abnormal_spinal_cord1.61342036
41MP0003879_abnormal_hair_cell1.49933428
42MP0002882_abnormal_neuron_morphology1.48383750
43MP0002066_abnormal_motor_capabilities/c1.44116389
44MP0004142_abnormal_muscle_tone1.41242020
45MP0004885_abnormal_endolymph1.41178962
46MP0001529_abnormal_vocalization1.35661120
47MP0001188_hyperpigmentation1.34966245
48MP0001502_abnormal_circadian_rhythm1.29395473
49MP0003633_abnormal_nervous_system1.24828168
50MP0001905_abnormal_dopamine_level1.24347259
51MP0000569_abnormal_digit_pigmentation1.23313881
52MP0002152_abnormal_brain_morphology1.16384919
53MP0005551_abnormal_eye_electrophysiolog1.07622818
54MP0003631_nervous_system_phenotype1.07104236
55MP0002229_neurodegeneration1.02088694
56MP0000751_myopathy1.00549015
57MP0002069_abnormal_eating/drinking_beha0.93485844
58MP0005394_taste/olfaction_phenotype0.93116127
59MP0005499_abnormal_olfactory_system0.93116127
60MP0000631_abnormal_neuroendocrine_gland0.91067442
61MP0004742_abnormal_vestibular_system0.90711051
62MP0008872_abnormal_physiological_respon0.90611112
63MP0004145_abnormal_muscle_electrophysio0.89903340
64MP0003634_abnormal_glial_cell0.86718561
65MP0004085_abnormal_heartbeat0.85378163
66MP0001177_atelectasis0.85100416
67MP0002752_abnormal_somatic_nervous0.83387582
68MP0004147_increased_porphyrin_level0.80955384
69MP0001963_abnormal_hearing_physiology0.80943050
70MP0010386_abnormal_urinary_bladder0.79489729
71MP0008874_decreased_physiological_sensi0.78026742
72MP0000013_abnormal_adipose_tissue0.77120267
73MP0003632_abnormal_nervous_system0.76497424
74MP0008877_abnormal_DNA_methylation0.76062409
75MP0005187_abnormal_penis_morphology0.75789323
76MP0005535_abnormal_body_temperature0.74974096
77MP0003121_genomic_imprinting0.74146178
78MP0003283_abnormal_digestive_organ0.72863115
79MP0002837_dystrophic_cardiac_calcinosis0.71897507
80MP0004130_abnormal_muscle_cell0.71577404
81MP0002638_abnormal_pupillary_reflex0.70864362
82MP0004215_abnormal_myocardial_fiber0.70135746
83MP0003690_abnormal_glial_cell0.69931799
84MP0000639_abnormal_adrenal_gland0.69473929
85MP0003123_paternal_imprinting0.67329746
86MP0003045_fibrosis0.66628057
87MP0003137_abnormal_impulse_conducting0.66619142
88MP0001346_abnormal_lacrimal_gland0.66111694
89MP0002876_abnormal_thyroid_physiology0.66091543
90MP0004043_abnormal_pH_regulation0.66064690
91MP0001299_abnormal_eye_distance/0.65666835
92MP0002090_abnormal_vision0.65060511
93MP0003861_abnormal_nervous_system0.65023976
94MP0000920_abnormal_myelination0.64703294
95MP0001348_abnormal_lacrimal_gland0.64531341
96MP0004233_abnormal_muscle_weight0.64330489
97MP0005409_darkened_coat_color0.63589958
98MP0006072_abnormal_retinal_apoptosis0.63570975
99MP0000604_amyloidosis0.62659000
100MP0001943_abnormal_respiration0.60595101
101MP0000681_abnormal_thyroid_gland0.59457574
102MP0000026_abnormal_inner_ear0.58975366
103MP0004484_altered_response_of0.58659469
104MP0010769_abnormal_survival0.57862551
105MP0002082_postnatal_lethality0.57486879
106MP0010770_preweaning_lethality0.57486879
107MP0000566_synostosis0.57182066
108MP0008961_abnormal_basal_metabolism0.56460800
109MP0001664_abnormal_digestion0.54907158
110MP0010768_mortality/aging0.54290858
111MP0001485_abnormal_pinna_reflex0.53206705
112MP0002751_abnormal_autonomic_nervous0.52402870

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.16051216
2Myokymia (HP:0002411)6.21024139
3Focal seizures (HP:0007359)5.59872081
4Visual hallucinations (HP:0002367)5.05633597
5Epileptic encephalopathy (HP:0200134)4.89618058
6Atonic seizures (HP:0010819)4.65541977
7Febrile seizures (HP:0002373)4.45415682
8Progressive cerebellar ataxia (HP:0002073)4.41615141
9Absence seizures (HP:0002121)4.23731228
10Dialeptic seizures (HP:0011146)3.82150755
11Generalized tonic-clonic seizures (HP:0002069)3.82148460
12Action tremor (HP:0002345)3.68341806
13Broad-based gait (HP:0002136)3.61290155
14Hyperventilation (HP:0002883)3.55107664
15Ankle clonus (HP:0011448)3.51548855
16Supranuclear gaze palsy (HP:0000605)3.44643260
17Mutism (HP:0002300)3.32679626
18Poor eye contact (HP:0000817)3.27735446
19Impaired vibration sensation in the lower limbs (HP:0002166)3.14247241
20Urinary bladder sphincter dysfunction (HP:0002839)3.13341404
21Gaze-evoked nystagmus (HP:0000640)3.12289458
22Truncal ataxia (HP:0002078)3.11379022
23Abnormal eating behavior (HP:0100738)3.11335070
24Obstructive sleep apnea (HP:0002870)3.10382657
25Depression (HP:0000716)3.06592741
26Abnormal social behavior (HP:0012433)3.01430994
27Impaired social interactions (HP:0000735)3.01430994
28Excessive salivation (HP:0003781)2.99757092
29Drooling (HP:0002307)2.99757092
30Dysdiadochokinesis (HP:0002075)2.96795541
31Papilledema (HP:0001085)2.91650640
32Progressive inability to walk (HP:0002505)2.90454131
33Anxiety (HP:0000739)2.89985552
34Genetic anticipation (HP:0003743)2.89613787
35Postural instability (HP:0002172)2.80649527
36Amblyopia (HP:0000646)2.74304163
37Pheochromocytoma (HP:0002666)2.73974417
38Dysmetria (HP:0001310)2.73688961
39Polyphagia (HP:0002591)2.71847706
40Urinary urgency (HP:0000012)2.69068223
41Limb dystonia (HP:0002451)2.68688027
42Abnormality of the corticospinal tract (HP:0002492)2.66022299
43Abnormality of the lower motor neuron (HP:0002366)2.62102234
44Spastic gait (HP:0002064)2.60634366
45Epileptiform EEG discharges (HP:0011182)2.60103653
46Impaired smooth pursuit (HP:0007772)2.55215296
47Insidious onset (HP:0003587)2.54175316
48Termporal pattern (HP:0011008)2.54175316
49EEG with generalized epileptiform discharges (HP:0011198)2.52515845
50Torticollis (HP:0000473)2.50080689
51Hemiparesis (HP:0001269)2.49219280
52Fetal akinesia sequence (HP:0001989)2.48806654
53Abnormality of binocular vision (HP:0011514)2.47975160
54Diplopia (HP:0000651)2.47975160
55Scanning speech (HP:0002168)2.46928866
56Absent speech (HP:0001344)2.43674330
57Amyotrophic lateral sclerosis (HP:0007354)2.40654732
58Hypsarrhythmia (HP:0002521)2.39713165
59Agitation (HP:0000713)2.39244957
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.38779354
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.38779354
62Bradykinesia (HP:0002067)2.36026179
63Neuroendocrine neoplasm (HP:0100634)2.35859239
64Inability to walk (HP:0002540)2.31943214
65Stereotypic behavior (HP:0000733)2.29503607
66Lower limb muscle weakness (HP:0007340)2.28158206
67Focal dystonia (HP:0004373)2.28110567
68Abnormality of ocular smooth pursuit (HP:0000617)2.25241452
69Bundle branch block (HP:0011710)2.22117147
70Dysmetric saccades (HP:0000641)2.21531156
71Neurofibrillary tangles (HP:0002185)2.19325547
72Cerebral inclusion bodies (HP:0100314)2.17641215
73Prolonged QT interval (HP:0001657)2.16420664
74Hemiplegia (HP:0002301)2.15698066
75Intention tremor (HP:0002080)2.15235926
76Status epilepticus (HP:0002133)2.14784086
77Gait imbalance (HP:0002141)2.10257514
78Impaired vibratory sensation (HP:0002495)2.10143954
79Akinesia (HP:0002304)2.07897831
80Generalized myoclonic seizures (HP:0002123)2.06261373
81Ventricular fibrillation (HP:0001663)2.05649535
82Craniofacial dystonia (HP:0012179)2.05273137
83Blue irides (HP:0000635)2.04459149
84Megalencephaly (HP:0001355)2.03932242
85Inappropriate behavior (HP:0000719)2.03681081
86Syncope (HP:0001279)2.03145492
87Protruding tongue (HP:0010808)2.02935489
88Increased circulating renin level (HP:0000848)2.00469876
89Failure to thrive in infancy (HP:0001531)1.98721556
90Tetraplegia (HP:0002445)1.98289384
91Abnormality of salivation (HP:0100755)1.96302659
92Specific learning disability (HP:0001328)1.95843471
93Insomnia (HP:0100785)1.92813397
94Hypoventilation (HP:0002791)1.92236553
95Bronchomalacia (HP:0002780)1.91293254
96Cerebral hypomyelination (HP:0006808)1.89784713
97Macroorchidism (HP:0000053)1.88770373
98Aqueductal stenosis (HP:0002410)1.87410360
99Rigidity (HP:0002063)1.87169672
100Hyperthyroidism (HP:0000836)1.85714395
101Gait ataxia (HP:0002066)1.84180079
102Clonus (HP:0002169)1.83798222
103Incomplete penetrance (HP:0003829)1.83180535
104Psychosis (HP:0000709)1.82437090
105Hypoplasia of the brainstem (HP:0002365)1.81793161
106Aplasia/Hypoplasia of the brainstem (HP:0007362)1.81793161
107Neoplasm of the peripheral nervous system (HP:0100007)1.81283840
108Annular pancreas (HP:0001734)1.78986558
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78200687
110Abnormal EKG (HP:0003115)1.77950863
111Pointed chin (HP:0000307)1.77502160
112Neuronal loss in central nervous system (HP:0002529)1.77202624
113Sleep apnea (HP:0010535)1.77107992
114Abnormal hair whorl (HP:0010721)1.76724340
115Morphological abnormality of the pyramidal tract (HP:0002062)1.73846715
116Aplasia involving bones of the upper limbs (HP:0009823)1.72516914
117Aplasia of the phalanges of the hand (HP:0009802)1.72516914
118Aplasia involving bones of the extremities (HP:0009825)1.72516914
119Spastic tetraparesis (HP:0001285)1.71333087
120Thyroid-stimulating hormone excess (HP:0002925)1.67810075
121Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67382576
122Rapidly progressive (HP:0003678)1.60265079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.44629454
2MARK14.34547377
3MAP3K93.73068528
4EPHA43.27677918
5MAP3K43.25652631
6MINK12.88475148
7MAP2K72.79973195
8CASK2.69307366
9NTRK22.34307105
10MAP3K122.29781821
11PAK62.17916630
12DAPK22.12827309
13MAP2K41.97893097
14MAPK131.74754927
15KSR21.70856883
16NTRK11.63802365
17TNIK1.63676371
18KSR11.61928703
19PRKD31.60180718
20CAMKK11.56887409
21PLK21.53737468
22CDK51.51870046
23DAPK11.38865323
24PRPF4B1.36006419
25PHKG21.33441547
26PHKG11.33441547
27GRK51.28869942
28PNCK1.28640230
29CDK191.26324224
30PRKCG1.26175323
31RIPK41.23947884
32UHMK11.20942311
33FRK1.20785223
34FGFR21.20345257
35SIK21.19616164
36STK381.16831952
37LATS21.16144898
38ARAF1.12275684
39FES1.06412928
40SGK2231.06140742
41SGK4941.06140742
42CAMK2A1.00783600
43SGK20.99962971
44RIPK10.98207121
45MAP3K20.97129612
46CAMKK20.91603469
47CDK180.90153730
48PAK30.89243664
49CDK140.87643753
50CSNK1G20.87243451
51TYRO30.86976243
52CDK150.86724678
53STK110.82681898
54PRKCH0.80875489
55SGK30.80048614
56NEK60.79935503
57DYRK1A0.79060426
58CAMK10.78645172
59RET0.77582486
60AKT30.76090771
61TAOK10.75205073
62CDK11A0.74551402
63WNK30.72835989
64MAPK120.72486994
65CAMK2B0.70753737
66SGK10.67966084
67OXSR10.66139120
68LMTK20.65806372
69MAP3K130.65067946
70MARK20.64211792
71ERBB30.63928724
72ALK0.61216085
73RAF10.60878499
74PRKCZ0.56126450
75PRKCE0.56084135
76PINK10.54404453
77RPS6KA20.53149073
78CCNB10.52585542
79DYRK20.51677522
80TNK20.50896091
81BMPR20.49933525
82PKN10.49699290
83STK390.49478168
84RPS6KA30.49226401
85PIK3CA0.48020371
86CDC42BPA0.47397744
87WNK10.46865413
88SCYL20.46285707
89NEK10.46181989
90PDK10.45494050
91CAMK2D0.45093128
92MAPKAPK50.44921189
93SIK30.44745219
94MAP3K10.43966578
95CAMK2G0.43827479
96CAMK1G0.43508306
97FER0.43218853
98CSNK1D0.43214984
99MAP3K60.43180939
100MAPK100.42974776
101FYN0.40767793
102BCR0.40381738
103PTK2B0.39525611
104PDPK10.39135565
105ROCK20.39131997
106DMPK0.38499941
107ERBB20.37743788
108INSRR0.37221668
109CAMK1D0.36867090
110PRKAA10.36194918
111CAMK40.35968966
112CSNK1G30.35957606
113RPS6KB10.35511783
114PRKCB0.35054890
115MAP2K10.34949183
116ROCK10.33482495
117CSNK1E0.33359041
118BRAF0.32848115
119PRKG10.32551121
120EEF2K0.31292424
121PRKACA0.30932113
122GSK3B0.30704833
123OBSCN0.30445752

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.97888249
2Synaptic vesicle cycle_Homo sapiens_hsa047213.49862432
3GABAergic synapse_Homo sapiens_hsa047272.89339514
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.73916810
5Olfactory transduction_Homo sapiens_hsa047402.72302016
6Circadian entrainment_Homo sapiens_hsa047132.69750606
7Morphine addiction_Homo sapiens_hsa050322.56944258
8Glutamatergic synapse_Homo sapiens_hsa047242.55377763
9Long-term potentiation_Homo sapiens_hsa047202.54687986
10Amphetamine addiction_Homo sapiens_hsa050312.34616790
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22397875
12Dopaminergic synapse_Homo sapiens_hsa047282.20508133
13Salivary secretion_Homo sapiens_hsa049702.06536004
14Insulin secretion_Homo sapiens_hsa049111.98858653
15Cholinergic synapse_Homo sapiens_hsa047251.89524706
16Taste transduction_Homo sapiens_hsa047421.86940470
17Serotonergic synapse_Homo sapiens_hsa047261.78994764
18Gastric acid secretion_Homo sapiens_hsa049711.77642554
19Long-term depression_Homo sapiens_hsa047301.73746200
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71682976
21Renin secretion_Homo sapiens_hsa049241.70654310
22Cocaine addiction_Homo sapiens_hsa050301.67628806
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63931476
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61416916
25Collecting duct acid secretion_Homo sapiens_hsa049661.61359595
26Oxytocin signaling pathway_Homo sapiens_hsa049211.58785339
27Calcium signaling pathway_Homo sapiens_hsa040201.49325027
28GnRH signaling pathway_Homo sapiens_hsa049121.38741405
29Gap junction_Homo sapiens_hsa045401.38551505
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27597848
31Axon guidance_Homo sapiens_hsa043601.26920561
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25037632
33cAMP signaling pathway_Homo sapiens_hsa040241.21662130
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19425026
35Type II diabetes mellitus_Homo sapiens_hsa049301.19096998
36Vitamin B6 metabolism_Homo sapiens_hsa007501.15871313
37Estrogen signaling pathway_Homo sapiens_hsa049151.14424016
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12394984
39ErbB signaling pathway_Homo sapiens_hsa040121.08653002
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06797926
41Glioma_Homo sapiens_hsa052141.06384463
42Vibrio cholerae infection_Homo sapiens_hsa051101.05727392
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03523989
44Melanogenesis_Homo sapiens_hsa049161.01369038
45Cardiac muscle contraction_Homo sapiens_hsa042601.00730084
46Phototransduction_Homo sapiens_hsa047440.98837272
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96970568
48Oocyte meiosis_Homo sapiens_hsa041140.87037782
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.86401531
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79997787
51Dorso-ventral axis formation_Homo sapiens_hsa043200.77265355
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.76653404
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76246654
54Dilated cardiomyopathy_Homo sapiens_hsa054140.72677291
55Pancreatic secretion_Homo sapiens_hsa049720.72159918
56MAPK signaling pathway_Homo sapiens_hsa040100.72136156
57Thyroid hormone synthesis_Homo sapiens_hsa049180.71386536
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69394670
59Choline metabolism in cancer_Homo sapiens_hsa052310.66373768
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66128110
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64091283
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.63213804
63Ras signaling pathway_Homo sapiens_hsa040140.60108224
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59560521
65Alcoholism_Homo sapiens_hsa050340.59223720
66Endometrial cancer_Homo sapiens_hsa052130.58994719
67Type I diabetes mellitus_Homo sapiens_hsa049400.58717252
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54940644
69Glucagon signaling pathway_Homo sapiens_hsa049220.52998550
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52381412
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50498001
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49622103
73Rap1 signaling pathway_Homo sapiens_hsa040150.48876755
74AMPK signaling pathway_Homo sapiens_hsa041520.48781304
75VEGF signaling pathway_Homo sapiens_hsa043700.48762590
76mTOR signaling pathway_Homo sapiens_hsa041500.47864055
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47793644
78Tight junction_Homo sapiens_hsa045300.47115060
79Renal cell carcinoma_Homo sapiens_hsa052110.46094611
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.45919047
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45781223
82Nitrogen metabolism_Homo sapiens_hsa009100.44942158
83Insulin signaling pathway_Homo sapiens_hsa049100.44434433
84Endocytosis_Homo sapiens_hsa041440.44310322
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44303388
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44162217
87Wnt signaling pathway_Homo sapiens_hsa043100.44103769
88Circadian rhythm_Homo sapiens_hsa047100.43473472
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42084894
90Fatty acid biosynthesis_Homo sapiens_hsa000610.42073282
91Alzheimers disease_Homo sapiens_hsa050100.41716429
92Inositol phosphate metabolism_Homo sapiens_hsa005620.41312223
93Prion diseases_Homo sapiens_hsa050200.40869129
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39612634
95Bile secretion_Homo sapiens_hsa049760.38893694
96Colorectal cancer_Homo sapiens_hsa052100.38866323
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38509740
98Mineral absorption_Homo sapiens_hsa049780.38246411
99Non-small cell lung cancer_Homo sapiens_hsa052230.38168829
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37337876
101Prolactin signaling pathway_Homo sapiens_hsa049170.35836790
102Ovarian steroidogenesis_Homo sapiens_hsa049130.35365632
103Hippo signaling pathway_Homo sapiens_hsa043900.34492602
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.33558227
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31354715
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30741941
107Histidine metabolism_Homo sapiens_hsa003400.29234667
108Chemokine signaling pathway_Homo sapiens_hsa040620.28250093
109Butanoate metabolism_Homo sapiens_hsa006500.28040673
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27353806
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26945179
112beta-Alanine metabolism_Homo sapiens_hsa004100.26580979
113ABC transporters_Homo sapiens_hsa020100.26417029
114Arginine biosynthesis_Homo sapiens_hsa002200.23081912

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