LOXL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a lysyl oxidase, which likely functions as an amine oxidase and plays a role in the formation of crosslinks in collagens and elastin. Deletion of the related gene in mouse causes neonatal mortality with cleft palate, spine deformity, and defects in collagen organization. A mutation in this gene was found in a family with Stickler syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)7.97070092
2collagen fibril organization (GO:0030199)7.60787065
3protein heterotrimerization (GO:0070208)6.59917766
4sequestering of extracellular ligand from receptor (GO:0035581)6.14363901
5skin morphogenesis (GO:0043589)5.89230514
6dermatan sulfate biosynthetic process (GO:0030208)5.43126328
7cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.25718809
8endodermal cell differentiation (GO:0035987)5.19361485
9bone trabecula formation (GO:0060346)5.15446046
10type B pancreatic cell proliferation (GO:0044342)5.02724594
11dermatan sulfate metabolic process (GO:0030205)4.97686603
12wound healing, spreading of epidermal cells (GO:0035313)4.93092301
13negative regulation of homotypic cell-cell adhesion (GO:0034111)4.81324986
14positive regulation of endothelial cell apoptotic process (GO:2000353)4.72905890
15collagen metabolic process (GO:0032963)4.71061385
16cell adhesion mediated by integrin (GO:0033627)4.64772581
17collagen catabolic process (GO:0030574)4.62400793
18mesenchymal-epithelial cell signaling (GO:0060638)4.61574321
19regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.48185554
20barbed-end actin filament capping (GO:0051016)4.47207681
21multicellular organismal macromolecule metabolic process (GO:0044259)4.36077157
22peptidyl-proline hydroxylation (GO:0019511)4.35485710
23chondrocyte development (GO:0002063)4.22656703
24multicellular organismal catabolic process (GO:0044243)4.19536028
25negative regulation of fatty acid transport (GO:2000192)4.17410228
26keratan sulfate catabolic process (GO:0042340)4.12514762
27multicellular organismal metabolic process (GO:0044236)4.07330153
28extracellular fibril organization (GO:0043206)3.99431894
29craniofacial suture morphogenesis (GO:0097094)3.96914969
30wound healing, spreading of cells (GO:0044319)3.96585900
31extracellular matrix disassembly (GO:0022617)3.94517524
32fibril organization (GO:0097435)3.91652603
33negative regulation of focal adhesion assembly (GO:0051895)3.86884665
34negative regulation of cell junction assembly (GO:1901889)3.86884665
35negative regulation of adherens junction organization (GO:1903392)3.86884665
36axon extension involved in axon guidance (GO:0048846)3.78681357
37neuron projection extension involved in neuron projection guidance (GO:1902284)3.78681357
38metanephric mesenchyme development (GO:0072075)3.66594776
39chondroitin sulfate catabolic process (GO:0030207)3.65798658
40extracellular matrix assembly (GO:0085029)3.65342085
41cellular response to vitamin (GO:0071295)3.64201976
42protein hydroxylation (GO:0018126)3.63903705
43regulation of platelet aggregation (GO:0090330)3.63829440
44basement membrane organization (GO:0071711)3.62305502
45chondroitin sulfate biosynthetic process (GO:0030206)3.60000643
46cellular response to vitamin D (GO:0071305)3.57358531
47apoptotic cell clearance (GO:0043277)3.56285369
48regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.53916245
49regulation of tight junction assembly (GO:2000810)3.52800147
50positive regulation of macrophage cytokine production (GO:0060907)3.50214185
51cellular response to interferon-alpha (GO:0035457)3.47641089
52endothelial cell morphogenesis (GO:0001886)3.46988379
53positive regulation of macrophage activation (GO:0043032)3.43119391
54kidney mesenchyme development (GO:0072074)3.43003462
55heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.41738029
56positive regulation of astrocyte differentiation (GO:0048711)3.41569924
57positive regulation of blood vessel endothelial cell migration (GO:0043536)3.38267804
58extracellular matrix organization (GO:0030198)3.36389587
59extracellular structure organization (GO:0043062)3.34829117
60positive regulation of epithelial to mesenchymal transition (GO:0010718)3.32056667
61positive regulation of cartilage development (GO:0061036)3.31047606
62adhesion of symbiont to host (GO:0044406)3.29969833
63regulation of plasminogen activation (GO:0010755)3.29939389
64maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.29703203
65protein retention in ER lumen (GO:0006621)3.28755859
66positive regulation of osteoblast proliferation (GO:0033690)3.27978169
67extracellular regulation of signal transduction (GO:1900115)3.27561980
68extracellular negative regulation of signal transduction (GO:1900116)3.27561980
69hyaluronan catabolic process (GO:0030214)3.23805254
70negative regulation of smooth muscle cell migration (GO:0014912)3.23362414
71vascular endothelial growth factor signaling pathway (GO:0038084)3.22019955
72positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.17310908
73cell migration involved in heart development (GO:0060973)3.17283144
74negative regulation of chondrocyte differentiation (GO:0032331)3.17088711
75regulation of macrophage cytokine production (GO:0010935)3.15275126
76positive regulation of extracellular matrix organization (GO:1903055)3.13540376
77protein localization to cell surface (GO:0034394)3.12613365
78cranial suture morphogenesis (GO:0060363)3.12227612
79negative regulation of platelet activation (GO:0010544)3.12007261
80positive regulation of axon extension (GO:0045773)3.11365686
81glomerular basement membrane development (GO:0032836)3.11351052
82positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.11255693
83substrate-dependent cell migration (GO:0006929)3.09538626
84middle ear morphogenesis (GO:0042474)3.09249758
85epithelial cell-cell adhesion (GO:0090136)3.08201743
86embryonic cranial skeleton morphogenesis (GO:0048701)3.06285337
87regulation of cartilage development (GO:0061035)3.04660204
88platelet aggregation (GO:0070527)3.01650120
89retina vasculature morphogenesis in camera-type eye (GO:0061299)3.00447714
90plasma membrane repair (GO:0001778)2.99930484
91phagocytosis, recognition (GO:0006910)2.98389174
92negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.95611124
93outer ear morphogenesis (GO:0042473)2.94820372
94regulation of integrin-mediated signaling pathway (GO:2001044)2.93488118
95planar cell polarity pathway involved in neural tube closure (GO:0090179)2.93101845
96positive regulation of natural killer cell differentiation (GO:0032825)2.91912130
97cortical cytoskeleton organization (GO:0030865)2.90647669
98phagocytosis, engulfment (GO:0006911)2.89729504
99regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.89559149
100stress fiber assembly (GO:0043149)2.87081481
101endocardial cushion development (GO:0003197)2.86229131
102glial cell migration (GO:0008347)2.85153319
103regulation of chondrocyte differentiation (GO:0032330)2.84837420
104adhesion of symbiont to host cell (GO:0044650)2.84325383
105virion attachment to host cell (GO:0019062)2.84325383
106substrate adhesion-dependent cell spreading (GO:0034446)2.81060049
107regulation of monocyte chemotaxis (GO:0090025)2.80087751
108negative regulation of cartilage development (GO:0061037)2.80078169
109regulation of homotypic cell-cell adhesion (GO:0034110)2.79407341
110negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.78944302
111tooth mineralization (GO:0034505)2.78597188
112endochondral ossification (GO:0001958)2.77724906
113replacement ossification (GO:0036075)2.77724906
114positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.77603534
115negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.77058430
116wound healing (GO:0042060)2.76643661
117negative regulation of embryonic development (GO:0045992)2.75955499
118membrane invagination (GO:0010324)2.75711858
119regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74781713
120hyaluronan metabolic process (GO:0030212)2.73171884
121embryonic body morphogenesis (GO:0010172)2.72617176
122G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.71452933
123regulation of integrin activation (GO:0033623)2.71020147
124cellular response to amino acid stimulus (GO:0071230)2.69707479
125negative regulation of skeletal muscle tissue development (GO:0048642)2.68706596
126glycosaminoglycan catabolic process (GO:0006027)2.68470479
127negative regulation of nitric-oxide synthase activity (GO:0051001)2.67246399
128negative regulation of anoikis (GO:2000811)2.67077304
129muscle cell migration (GO:0014812)2.67022090
130COPI coating of Golgi vesicle (GO:0048205)2.66983454
131Golgi transport vesicle coating (GO:0048200)2.66983454
132cortical actin cytoskeleton organization (GO:0030866)2.66372607
133lipopolysaccharide biosynthetic process (GO:0009103)2.65823856
134cell aggregation (GO:0098743)2.62890606
135cartilage condensation (GO:0001502)2.62890606
136axon regeneration (GO:0031103)2.62273691
137regulation of smooth muscle cell migration (GO:0014910)2.62009163
138pinocytosis (GO:0006907)2.61993787
139regulation of platelet activation (GO:0010543)2.59790811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.11353463
2RARG_19884340_ChIP-ChIP_MEFs_Mouse5.51808550
3TP63_17297297_ChIP-ChIP_HaCaT_Human5.48721193
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.31998138
5RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.60434045
6TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.34605993
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.24424596
8CLOCK_20551151_ChIP-Seq_293T_Human3.16529474
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.88000639
10CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.87327405
11CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.86940886
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.86866848
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68321146
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.54206541
15CJUN_26792858_Chip-Seq_BT549_Human2.50689857
16BRD4_25478319_ChIP-Seq_HGPS_Human2.49305219
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.28152326
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.22547358
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.21546265
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.15387236
21ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.08469203
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.08068915
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.03574977
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.03188736
25* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.99512642
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98259231
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.97816387
28NRF2_20460467_ChIP-Seq_MEFs_Mouse1.97816387
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.96375235
30SMC1_22415368_ChIP-Seq_MEFs_Mouse1.93128738
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.91640056
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.91640056
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.91008994
34ELK1_22589737_ChIP-Seq_MCF10A_Human1.81853705
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.78276418
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76328831
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.76298177
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72032055
39JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71487055
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70809011
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67127067
42UBF1/2_26484160_Chip-Seq_HMECs_Human1.67126331
43TP53_22127205_ChIP-Seq_IMR90_Human1.64838568
44JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63492407
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.63407237
46SMC3_22415368_ChIP-Seq_MEFs_Mouse1.62676224
47TP53_18474530_ChIP-ChIP_U2OS_Human1.60121444
48* TP53_23651856_ChIP-Seq_MEFs_Mouse1.58579735
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.56338743
50HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.56242731
51ATF3_27146783_Chip-Seq_COLON_Human1.53112760
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50128805
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50036875
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48384485
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47844835
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47574685
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45646789
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.44110228
59MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.43188031
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.43141192
61SA1_22415368_ChIP-Seq_MEFs_Mouse1.42262355
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40722973
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37312576
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36872034
65NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.35849840
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31432094
67* SOX2_20726797_ChIP-Seq_SW620_Human1.30242906
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28485443
69TP53_16413492_ChIP-PET_HCT116_Human1.28345414
70ELK4_26923725_Chip-Seq_MESODERM_Mouse1.27055220
71NFI_21473784_ChIP-Seq_ESCs_Mouse1.26039123
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25844716
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.25340848
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24416745
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.18669096
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14184020
77SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11714695
78* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11622015
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11297067
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10457643
81SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10448400
82RACK7_27058665_Chip-Seq_MCF-7_Human1.09793552
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09404074
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07772483
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.07639650
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07011454
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.05881993
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05430866
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04685936
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03716315
91LXR_22292898_ChIP-Seq_THP-1_Human1.02538308
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02293407
93VDR_21846776_ChIP-Seq_THP-1_Human1.02113173
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01883663
95EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01596501
96RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01596501
97SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00597381
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.00219346
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.00219346
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99730255
101SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99487348
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99065239
103SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98921641
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97881115
105VDR_24763502_ChIP-Seq_THP-1_Human0.97833386
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97372117
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96285847
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96273427
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95571888
110BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93566693
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92725033
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92233666
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91708547
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91153299
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90519648
116* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90503687
117* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87980290
118EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87077024
119PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.86981966
120TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86479978
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85921372
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85539439
123* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85533062
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85374241
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85314990
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83547097
127ISL1_27105846_Chip-Seq_CPCs_Mouse0.83133995
128PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82946214
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.82824965
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82228173
131CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81571261
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80760565
133RUNX1_22412390_ChIP-Seq_EML_Mouse0.80626172
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80137140
135CSB_26484114_Chip-Seq_FIBROBLAST_Human0.79740187
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.78569958
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77211867
138TFEB_21752829_ChIP-Seq_HELA_Human0.76867280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.40984920
2MP0005503_abnormal_tendon_morphology5.68756823
3MP0005275_abnormal_skin_tensile4.99354850
4MP0003279_aneurysm4.41598450
5MP0003705_abnormal_hypodermis_morpholog3.81851642
6MP0001958_emphysema3.24484694
7MP0009384_cardiac_valve_regurgitation2.61028704
8MP0005257_abnormal_intraocular_pressure2.58136953
9MP0004272_abnormal_basement_membrane2.49513276
10MP0005623_abnormal_meninges_morphology2.45282969
11MP0005508_abnormal_skeleton_morphology2.41438319
12MP0006054_spinal_hemorrhage2.36585231
13MP0009250_abnormal_appendicular_skeleto2.24792777
14MP0001542_abnormal_bone_strength2.23437923
15MP0010030_abnormal_orbit_morphology2.23339898
16MP0004858_abnormal_nervous_system2.21103820
17MP0003566_abnormal_cell_adhesion2.14739264
18MP0005058_abnormal_lysosome_morphology2.09912154
19MP0005023_abnormal_wound_healing2.05970300
20MP0003091_abnormal_cell_migration2.00229076
21MP0002295_abnormal_pulmonary_circulatio1.89591572
22MP0002060_abnormal_skin_morphology1.87089183
23MP0010352_gastrointestinal_tract_polyps1.84351575
24MP0002933_joint_inflammation1.79837672
25MP0001243_abnormal_dermal_layer1.71075893
26MP0004134_abnormal_chest_morphology1.67471036
27MP0003385_abnormal_body_wall1.65522322
28MP0002282_abnormal_trachea_morphology1.65238673
29MP0002108_abnormal_muscle_morphology1.64181602
30MP0001299_abnormal_eye_distance/1.62828073
31MP0005390_skeleton_phenotype1.58898981
32MP0000163_abnormal_cartilage_morphology1.55912528
33MP0002896_abnormal_bone_mineralization1.55531867
34MP0001348_abnormal_lacrimal_gland1.50876500
35MP0000767_abnormal_smooth_muscle1.47914592
36MP0005464_abnormal_platelet_physiology1.47866622
37MP0002115_abnormal_skeleton_extremities1.45528509
38MP0000733_abnormal_muscle_development1.45359952
39MP0003828_pulmonary_edema1.30750181
40MP0002113_abnormal_skeleton_development1.26813807
41MP0009053_abnormal_anal_canal1.24852947
42MP0000428_abnormal_craniofacial_morphol1.17841240
43MP0002998_abnormal_bone_remodeling1.16149177
44MP0000750_abnormal_muscle_regeneration1.15941624
45MP0002877_abnormal_melanocyte_morpholog1.14891700
46MP0001533_abnormal_skeleton_physiology1.14388777
47MP0002932_abnormal_joint_morphology1.14249459
48MP0000013_abnormal_adipose_tissue1.09611205
49MP0003942_abnormal_urinary_system1.09473765
50MP0001849_ear_inflammation1.08344932
51MP0003755_abnormal_palate_morphology1.07593043
52MP0000049_abnormal_middle_ear1.07388959
53MP0003283_abnormal_digestive_organ1.06566072
54MP0002089_abnormal_postnatal_growth/wei1.04610692
55MP0003172_abnormal_lysosome_physiology1.04540918
56MP0000751_myopathy1.04004054
57MP0008260_abnormal_autophagy1.03296762
58MP0002938_white_spotting1.01559033
59MP0010368_abnormal_lymphatic_system1.00858433
60MP0010386_abnormal_urinary_bladder1.00596950
61MP0005595_abnormal_vascular_smooth0.99315503
62MP0003795_abnormal_bone_structure0.99133426
63MP0002109_abnormal_limb_morphology0.97449947
64MP0005171_absent_coat_pigmentation0.95829972
65MP0004510_myositis0.92724689
66MP0002168_other_aberrant_phenotype0.91131748
67MP0009278_abnormal_bone_marrow0.91104152
68MP0005076_abnormal_cell_differentiation0.89486040
69MP0000432_abnormal_head_morphology0.88307813
70MP0002116_abnormal_craniofacial_bone0.86996288
71MP0002128_abnormal_blood_circulation0.84156841
72MP0003045_fibrosis0.83464726
73MP0003941_abnormal_skin_development0.83363236
74MP0005164_abnormal_response_to0.82397636
75MP0003448_altered_tumor_morphology0.82069236
76MP0002751_abnormal_autonomic_nervous0.80941995
77MP0000858_altered_metastatic_potential0.79738535
78MP0000534_abnormal_ureter_morphology0.79718985
79MP0001614_abnormal_blood_vessel0.79152636
80MP0003937_abnormal_limbs/digits/tail_de0.78510128
81MP0006082_CNS_inflammation0.78170287
82MP0002111_abnormal_tail_morphology0.78018743
83MP0003115_abnormal_respiratory_system0.77555142
84MP0002177_abnormal_outer_ear0.75381645
85MP0000759_abnormal_skeletal_muscle0.74032239
86MP0004084_abnormal_cardiac_muscle0.73784795
87MP0002249_abnormal_larynx_morphology0.72062996
88MP0001175_abnormal_lung_morphology0.71284026
89MP0005197_abnormal_uvea_morphology0.71041803
90MP0000762_abnormal_tongue_morphology0.70804142
91MP0002114_abnormal_axial_skeleton0.69777807
92MP0001879_abnormal_lymphatic_vessel0.69728108
93MP0003935_abnormal_craniofacial_develop0.67909153
94MP0001915_intracranial_hemorrhage0.67651369
95MP0002254_reproductive_system_inflammat0.67118376
96MP0005248_abnormal_Harderian_gland0.66602352
97MP0000749_muscle_degeneration0.65515806
98MP0000343_altered_response_to0.64229150
99MP0002233_abnormal_nose_morphology0.64195116
100MP0004808_abnormal_hematopoietic_stem0.61481809
101MP0000003_abnormal_adipose_tissue0.61399012
102MP0005193_abnormal_anterior_eye0.60817950
103MP0008007_abnormal_cellular_replicative0.60687321
104MP0005165_increased_susceptibility_to0.59871178
105MP0009840_abnormal_foam_cell0.57766431
106MP0008004_abnormal_stomach_pH0.57749803
107MP0002419_abnormal_innate_immunity0.54916070
108MP0003950_abnormal_plasma_membrane0.54698302
109MP0003634_abnormal_glial_cell0.54614744
110MP0002925_abnormal_cardiovascular_devel0.54006225
111MP0004087_abnormal_muscle_fiber0.53710717
112MP0000358_abnormal_cell_content/0.53117019
113MP0002133_abnormal_respiratory_system0.52780874
114MP0005388_respiratory_system_phenotype0.52780874
115MP0003303_peritoneal_inflammation0.52777219
116MP0009379_abnormal_foot_pigmentation0.52701583
117MP0000604_amyloidosis0.52054272
118MP0000920_abnormal_myelination0.51596597
119MP0003300_gastrointestinal_ulcer0.51062396
120MP0004036_abnormal_muscle_relaxation0.49971077
121MP0008932_abnormal_embryonic_tissue0.49413502
122MP0005397_hematopoietic_system_phenotyp0.49311063
123MP0001545_abnormal_hematopoietic_system0.49311063
124MP0005369_muscle_phenotype0.49285731
125MP0005621_abnormal_cell_physiology0.49205444
126MP0004883_abnormal_blood_vessel0.49071118
127MP0001270_distended_abdomen0.48854726
128MP0000249_abnormal_blood_vessel0.47574883

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.72123887
2Premature rupture of membranes (HP:0001788)8.49450121
3Aortic dissection (HP:0002647)4.96007045
4Peritonitis (HP:0002586)4.75516264
5Soft skin (HP:0000977)4.69570192
6Abnormality of dentin (HP:0010299)4.38038651
7Vertebral compression fractures (HP:0002953)4.37913377
8Shallow orbits (HP:0000586)4.32467164
9Neonatal short-limb short stature (HP:0008921)4.29698731
10Atrophic scars (HP:0001075)4.18396298
11Biconcave vertebral bodies (HP:0004586)4.18011220
12Aortic aneurysm (HP:0004942)3.98219909
13Ankle contracture (HP:0006466)3.97270149
14Genu recurvatum (HP:0002816)3.80099351
15Cervical subluxation (HP:0003308)3.77549740
16Dilatation of the ascending aorta (HP:0005111)3.77045605
17Bladder diverticulum (HP:0000015)3.69134772
18Cerebral aneurysm (HP:0004944)3.66464051
19Fragile skin (HP:0001030)3.64342559
20Wormian bones (HP:0002645)3.61851283
21Blue sclerae (HP:0000592)3.45594137
22Broad metatarsal (HP:0001783)3.40266244
23Hypoventilation (HP:0002791)3.21760203
24Spinal rigidity (HP:0003306)3.16346857
25Hand muscle atrophy (HP:0009130)3.14831579
26Type 1 muscle fiber predominance (HP:0003803)3.05624342
27Mitral valve prolapse (HP:0001634)3.02988560
28Follicular hyperkeratosis (HP:0007502)2.93839779
29Abnormality of the acetabulum (HP:0003170)2.91557871
30Abnormal delivery (HP:0001787)2.86507513
31Mesomelia (HP:0003027)2.84356309
32Upper limb muscle weakness (HP:0003484)2.76388973
33Hypoplasia of the iris (HP:0007676)2.71118398
34Wrist flexion contracture (HP:0001239)2.70562739
35Increased connective tissue (HP:0009025)2.68838494
36Vascular tortuosity (HP:0004948)2.67817088
37Coxa vara (HP:0002812)2.67161582
38Hyperextensible skin (HP:0000974)2.64302425
39Elbow flexion contracture (HP:0002987)2.60984804
40Osteoarthritis (HP:0002758)2.59094585
41Overgrowth (HP:0001548)2.59072871
42Mild short stature (HP:0003502)2.52398675
43Bowel diverticulosis (HP:0005222)2.51484465
44Infantile muscular hypotonia (HP:0008947)2.51380125
45Short nail (HP:0001799)2.49770750
46Ectopia lentis (HP:0001083)2.44877772
47Narrow nasal bridge (HP:0000446)2.43141825
48Radial bowing (HP:0002986)2.41639052
49Dysostosis multiplex (HP:0000943)2.37628329
50Slender build (HP:0001533)2.37167250
51Epiphyseal dysplasia (HP:0002656)2.33849911
52Breech presentation (HP:0001623)2.32381601
53Joint laxity (HP:0001388)2.32009618
54Wide anterior fontanel (HP:0000260)2.31445520
55Beaking of vertebral bodies (HP:0004568)2.31053406
56Joint stiffness (HP:0001387)2.30237261
57Arterial tortuosity (HP:0005116)2.29648888
58Disproportionate tall stature (HP:0001519)2.28469309
59Abnormality of the calcaneus (HP:0008364)2.27542132
60Hypoplastic ischia (HP:0003175)2.26287982
61Spinal cord compression (HP:0002176)2.25442201
62Cupped ribs (HP:0000887)2.25436741
63Mildly elevated creatine phosphokinase (HP:0008180)2.24291177
64Platyspondyly (HP:0000926)2.23675577
65Nonimmune hydrops fetalis (HP:0001790)2.23326978
66Round ear (HP:0100830)2.22334952
67Osteolytic defects of the hand bones (HP:0009699)2.21172865
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.21172865
69Generalized amyotrophy (HP:0003700)2.20567063
70Mitral regurgitation (HP:0001653)2.20356293
71Bell-shaped thorax (HP:0001591)2.19113728
72Abnormality of liposaccharide metabolism (HP:0010968)2.17947748
73Abnormality of glycosphingolipid metabolism (HP:0004343)2.17947748
74Abnormality of glycolipid metabolism (HP:0010969)2.17947748
75Deformed tarsal bones (HP:0008119)2.17676922
76Aneurysm (HP:0002617)2.16623243
77Broad long bones (HP:0005622)2.16597355
78Long toe (HP:0010511)2.16096125
79Abnormality of the peritoneum (HP:0002585)2.16081556
80Calcaneovalgus deformity (HP:0001848)2.15318164
81Deviation of the hallux (HP:0010051)2.14825274
82Spondylolisthesis (HP:0003302)2.13470647
83Decreased skull ossification (HP:0004331)2.13345011
84Broad ribs (HP:0000885)2.13237090
85Ovoid vertebral bodies (HP:0003300)2.10497320
86Mitral stenosis (HP:0001718)2.09636585
87Aortic valve stenosis (HP:0001650)2.08268119
88Ulnar bowing (HP:0003031)2.07623424
89Hallux valgus (HP:0001822)2.06909463
90Femoral bowing (HP:0002980)2.05901557
91Tibial bowing (HP:0002982)2.05205793
92Increased variability in muscle fiber diameter (HP:0003557)2.04242451
93Camptodactyly of toe (HP:0001836)2.04225503
94Coronal craniosynostosis (HP:0004440)2.02217716
95Syringomyelia (HP:0003396)2.02174525
96Spinal cord lesions (HP:0100561)2.02174525
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.01969121
98Abnormality of skull ossification (HP:0002703)2.01758969
99Abnormality of polysaccharide metabolism (HP:0011012)2.00461064
100Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00461064
101Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00461064
102Urinary glycosaminoglycan excretion (HP:0003541)1.99972437
103Mucopolysacchariduria (HP:0008155)1.99972437
104Increased mean platelet volume (HP:0011877)1.99118876
105Renal duplication (HP:0000075)1.98166929
106Bowed forearm bones (HP:0003956)1.96939917
107Bowing of the arm (HP:0006488)1.96939917
108White forelock (HP:0002211)1.96642026
109Inguinal hernia (HP:0000023)1.93629568
110Peripheral hypomyelination (HP:0007182)1.92520604
111Increased density of long bones (HP:0006392)1.92259959
112Pulmonary artery stenosis (HP:0004415)1.90565535
113Petechiae (HP:0000967)1.90203890
114Abnormality of the ischium (HP:0003174)1.86731671
115Flat cornea (HP:0007720)1.86112844
116Thin bony cortex (HP:0002753)1.85936378
117Abnormal platelet volume (HP:0011876)1.85639162
118Aortic regurgitation (HP:0001659)1.85603601
119Venous abnormality (HP:0002624)1.82577542
120Limb-girdle muscle weakness (HP:0003325)1.82164873
121Flexion contracture of toe (HP:0005830)1.81821153
122Joint contractures involving the joints of the feet (HP:0100492)1.81821153
123Scapular winging (HP:0003691)1.81147085
124Osteopenia (HP:0000938)1.80426906
125Abnormality of skeletal muscle fiber size (HP:0012084)1.79636586
126Thin ribs (HP:0000883)1.79094658
127Entropion (HP:0000621)1.79085735
128Flat capital femoral epiphysis (HP:0003370)1.79051255
129Purpura (HP:0000979)1.78064742
130Upper limb amyotrophy (HP:0009129)1.77698129
131Distal upper limb amyotrophy (HP:0007149)1.77698129
132Achilles tendon contracture (HP:0001771)1.76939173
133Natal tooth (HP:0000695)1.75115174
134Knee flexion contracture (HP:0006380)1.74389873
135Tarsal synostosis (HP:0008368)1.73647996
136Delayed cranial suture closure (HP:0000270)1.70341438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.81858953
2TTN4.09879077
3TRIB33.88060762
4LATS23.20119289
5PDGFRA3.01671843
6NME22.46707773
7PIM22.33607505
8PKN22.29888639
9PAK22.29312305
10ERN12.27916062
11LATS12.23203408
12TLK12.21036849
13SIK12.06323454
14SIK32.02566934
15BMX2.00036212
16TESK11.91471753
17NEK91.91084002
18EPHB21.85698783
19MAP4K21.80317216
20LIMK11.79616512
21BCR1.77697951
22TRPM71.77624221
23EPHA31.74400486
24MOS1.73941661
25LMTK21.66459910
26FER1.66351643
27RPS6KA41.58923365
28TESK21.54008053
29BLK1.53597565
30PTK2B1.51794619
31TRIM281.51750141
32LRRK21.50582936
33ERBB41.50212126
34PTK21.46793067
35DMPK1.42768039
36EIF2AK11.40206638
37PAK31.37425000
38PIK3CG1.35519275
39PAK41.25367038
40ARAF1.21447295
41TGFBR21.20338484
42ILK1.15594176
43ROCK11.09075516
44PIK3CA1.08538399
45TAOK21.06935494
46MET1.03833574
47FLT31.02059311
48KIT1.00426553
49MAPK70.97024587
50STK30.91580294
51CSF1R0.91285812
52FGR0.90734156
53MYLK0.90619698
54DAPK30.89828788
55FGFR10.85532491
56BCKDK0.85148519
57MAP3K60.83517099
58AKT30.81908108
59JAK30.81396579
60PDGFRB0.81363076
61TGFBR10.81015141
62PAK10.80894397
63STK160.79994338
64PTK60.78533416
65ADRBK10.77877318
66ZAP700.77416619
67ROCK20.74073773
68RIPK10.73512805
69ABL20.72656514
70ADRBK20.72053931
71MAP3K30.70631598
72EPHA20.70312321
73TBK10.69655779
74DYRK1B0.69421266
75ERBB30.69146685
76MAP3K110.68806751
77EPHB10.68165895
78INSR0.67805487
79TYK20.67763075
80GSK3A0.67659579
81PRKD20.67653912
82MTOR0.65338927
83PRKG20.65010829
84DYRK30.64159161
85MAP2K10.63343983
86KSR10.63200013
87EEF2K0.60836593
88MAP2K30.60182669
89PLK20.59272649
90SCYL20.58144686
91STK38L0.57222591
92MAP3K50.56780180
93GRK70.51941950
94CDK140.50982197
95CSNK1G30.50425643
96IKBKB0.48837612
97MAPKAPK50.48192304
98MAP3K80.47975910
99PRKD10.47722380
100RPS6KA20.47479264
101RET0.47164836
102DYRK1A0.45536619
103TAOK10.44963519
104MKNK10.43544540
105CDK150.41111254
106CSNK1A1L0.40167294
107CSNK1G20.39913419
108JAK10.39216331
109IRAK10.39051244
110CDC42BPA0.38484606
111SRC0.38448180
112MATK0.38225034
113CDK11A0.37097134
114CDK60.36843810
115MAP2K70.36004871
116DYRK20.35293321
117MAPKAPK30.34828239
118RIPK40.34375593
119PRKCD0.33963631
120STK100.33912832
121CDK180.33875785
122NTRK10.33133431
123BRAF0.31764204
124PAK60.31598639
125CDK80.31371411
126KDR0.31174838
127MARK20.30325460
128ABL10.29788221
129NUAK10.28815196
130MAPKAPK20.28772283
131MAP3K100.28624271
132MAP3K140.28623734
133HCK0.28472657
134PKN10.26595333
135STK380.26308081
136CAMKK20.26296837
137CSK0.25314432
138MAPK10.21109930

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.70429131
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.18199442
3Focal adhesion_Homo sapiens_hsa045103.16191677
4Malaria_Homo sapiens_hsa051442.98587050
5Protein digestion and absorption_Homo sapiens_hsa049742.50186527
6Bladder cancer_Homo sapiens_hsa052192.49743047
7Proteoglycans in cancer_Homo sapiens_hsa052052.39927121
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.21980953
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.03699897
10TGF-beta signaling pathway_Homo sapiens_hsa043501.97637082
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.95793134
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.95545448
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.93339760
14MicroRNAs in cancer_Homo sapiens_hsa052061.89189120
15Amoebiasis_Homo sapiens_hsa051461.84601686
16Dilated cardiomyopathy_Homo sapiens_hsa054141.84206873
17p53 signaling pathway_Homo sapiens_hsa041151.82277857
18PI3K-Akt signaling pathway_Homo sapiens_hsa041511.73336502
19Small cell lung cancer_Homo sapiens_hsa052221.67194900
20Adherens junction_Homo sapiens_hsa045201.66568068
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64292113
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56773350
23Hippo signaling pathway_Homo sapiens_hsa043901.56090632
24Shigellosis_Homo sapiens_hsa051311.50173334
25Melanoma_Homo sapiens_hsa052181.45892419
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.44000439
27Chronic myeloid leukemia_Homo sapiens_hsa052201.43670067
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.40044394
29Galactose metabolism_Homo sapiens_hsa000521.36047740
30Basal cell carcinoma_Homo sapiens_hsa052171.34094197
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.29022409
32Phagosome_Homo sapiens_hsa041451.26644854
33Viral myocarditis_Homo sapiens_hsa054161.15339398
34Ribosome_Homo sapiens_hsa030101.13997985
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12161193
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08588548
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.07689462
38TNF signaling pathway_Homo sapiens_hsa046681.07094541
39HTLV-I infection_Homo sapiens_hsa051661.06721428
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.02720656
41Staphylococcus aureus infection_Homo sapiens_hsa051501.02428916
42Prostate cancer_Homo sapiens_hsa052151.02030864
43Pentose phosphate pathway_Homo sapiens_hsa000301.01371097
44Hedgehog signaling pathway_Homo sapiens_hsa043401.01149625
45Glioma_Homo sapiens_hsa052140.99689289
46HIF-1 signaling pathway_Homo sapiens_hsa040660.98998148
47Platelet activation_Homo sapiens_hsa046110.97625976
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97143967
49Apoptosis_Homo sapiens_hsa042100.96867017
50Pancreatic cancer_Homo sapiens_hsa052120.96632943
51Other glycan degradation_Homo sapiens_hsa005110.93298650
52One carbon pool by folate_Homo sapiens_hsa006700.90771758
53Rap1 signaling pathway_Homo sapiens_hsa040150.90096185
54Pathways in cancer_Homo sapiens_hsa052000.89624981
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87311289
56Toxoplasmosis_Homo sapiens_hsa051450.86700601
57Leishmaniasis_Homo sapiens_hsa051400.86006593
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85667072
59Sulfur relay system_Homo sapiens_hsa041220.85654939
60Systemic lupus erythematosus_Homo sapiens_hsa053220.85463326
61N-Glycan biosynthesis_Homo sapiens_hsa005100.84304141
62Wnt signaling pathway_Homo sapiens_hsa043100.84200076
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84172579
64Hepatitis B_Homo sapiens_hsa051610.83612789
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.81137971
66Alcoholism_Homo sapiens_hsa050340.77893442
67Fructose and mannose metabolism_Homo sapiens_hsa000510.75004828
68Salmonella infection_Homo sapiens_hsa051320.74194529
69Axon guidance_Homo sapiens_hsa043600.73161628
70Viral carcinogenesis_Homo sapiens_hsa052030.71457768
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70911594
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70735423
73Protein export_Homo sapiens_hsa030600.70636682
74Melanogenesis_Homo sapiens_hsa049160.67127619
75Lysosome_Homo sapiens_hsa041420.66869564
76Osteoclast differentiation_Homo sapiens_hsa043800.64852802
77Renal cell carcinoma_Homo sapiens_hsa052110.62177616
78Prion diseases_Homo sapiens_hsa050200.62059656
79Gap junction_Homo sapiens_hsa045400.61030418
80Tight junction_Homo sapiens_hsa045300.59795832
81Pertussis_Homo sapiens_hsa051330.58447325
82Glutathione metabolism_Homo sapiens_hsa004800.58317228
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58224472
84Sphingolipid metabolism_Homo sapiens_hsa006000.57162829
85Chemokine signaling pathway_Homo sapiens_hsa040620.55193766
86Cell cycle_Homo sapiens_hsa041100.54994011
87VEGF signaling pathway_Homo sapiens_hsa043700.54365208
88Biosynthesis of amino acids_Homo sapiens_hsa012300.52317754
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.51355675
90Tuberculosis_Homo sapiens_hsa051520.50605081
91Asthma_Homo sapiens_hsa053100.50591785
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49893151
93Ras signaling pathway_Homo sapiens_hsa040140.49260388
94Cocaine addiction_Homo sapiens_hsa050300.48729629
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48402152
96Endocytosis_Homo sapiens_hsa041440.46837298
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46243676
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46156666
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.44341587
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43980608
101Rheumatoid arthritis_Homo sapiens_hsa053230.42716729
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41626603
103GnRH signaling pathway_Homo sapiens_hsa049120.41491187
104Colorectal cancer_Homo sapiens_hsa052100.39983047
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.39135774
106Legionellosis_Homo sapiens_hsa051340.39046180
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.38875888
108Steroid biosynthesis_Homo sapiens_hsa001000.38795880
109Acute myeloid leukemia_Homo sapiens_hsa052210.38633060
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37516316
111Base excision repair_Homo sapiens_hsa034100.36785572
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.36637454
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36582693
114Vibrio cholerae infection_Homo sapiens_hsa051100.36232254
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35874004
116Thyroid cancer_Homo sapiens_hsa052160.35432812
117Hematopoietic cell lineage_Homo sapiens_hsa046400.35311366
118African trypanosomiasis_Homo sapiens_hsa051430.35218235
119Notch signaling pathway_Homo sapiens_hsa043300.34229754
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.33778608
121Epstein-Barr virus infection_Homo sapiens_hsa051690.32917555
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32619062
123Estrogen signaling pathway_Homo sapiens_hsa049150.31796782
124FoxO signaling pathway_Homo sapiens_hsa040680.31311627
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31244793

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