LPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, alternative pathway (GO:0006957)9.12558389
2L-phenylalanine catabolic process (GO:0006559)8.22619245
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)8.22619245
4glyoxylate metabolic process (GO:0046487)8.01272278
5regulation of protein activation cascade (GO:2000257)7.93585136
6regulation of fibrinolysis (GO:0051917)7.85329930
7ethanol oxidation (GO:0006069)7.60340053
8regulation of complement activation (GO:0030449)7.58562588
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.43644551
10L-phenylalanine metabolic process (GO:0006558)7.43644551
11negative regulation of fibrinolysis (GO:0051918)7.04483106
12drug metabolic process (GO:0017144)6.81647331
13urea metabolic process (GO:0019627)6.74805351
14oxidative demethylation (GO:0070989)6.53748079
15imidazole-containing compound metabolic process (GO:0052803)6.42534941
16protein carboxylation (GO:0018214)6.32644355
17peptidyl-glutamic acid carboxylation (GO:0017187)6.32644355
18aromatic amino acid family catabolic process (GO:0009074)6.25639911
19nitrogen cycle metabolic process (GO:0071941)6.11170236
20serine family amino acid catabolic process (GO:0009071)6.09884085
21ethanol metabolic process (GO:0006067)6.04850396
22fibrinolysis (GO:0042730)5.98033772
23bile acid biosynthetic process (GO:0006699)5.90239407
24blood coagulation, intrinsic pathway (GO:0007597)5.84126763
25urea cycle (GO:0000050)5.73749987
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.64877760
27protein activation cascade (GO:0072376)5.47804429
28cellular glucuronidation (GO:0052695)5.45920577
29opsonization (GO:0008228)5.44762210
30regulation of triglyceride catabolic process (GO:0010896)5.38249156
31complement activation (GO:0006956)5.32554998
32complement activation, classical pathway (GO:0006958)5.22781426
33bile acid metabolic process (GO:0008206)5.20336500
34uronic acid metabolic process (GO:0006063)5.15878743
35glucuronate metabolic process (GO:0019585)5.15878743
36phenylpropanoid metabolic process (GO:0009698)5.14190418
37tyrosine metabolic process (GO:0006570)5.07767551
38glycine metabolic process (GO:0006544)5.07599492
39negative regulation of cholesterol transport (GO:0032375)5.01298104
40negative regulation of sterol transport (GO:0032372)5.01298104
41regulation of plasminogen activation (GO:0010755)4.92797558
42S-adenosylmethionine metabolic process (GO:0046500)4.90225455
43bile acid and bile salt transport (GO:0015721)4.88465822
44regulation of humoral immune response (GO:0002920)4.80924334
45glutamate metabolic process (GO:0006536)4.76693277
46negative regulation of protein activation cascade (GO:2000258)4.75718398
47disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.74229089
48killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.74229089
49cytolysis (GO:0019835)4.60588947
50indole-containing compound catabolic process (GO:0042436)4.50547171
51indolalkylamine catabolic process (GO:0046218)4.50547171
52tryptophan catabolic process (GO:0006569)4.50547171
53alkaloid metabolic process (GO:0009820)4.48886556
54acute-phase response (GO:0006953)4.46798038
55negative regulation of hemostasis (GO:1900047)4.44495008
56negative regulation of blood coagulation (GO:0030195)4.44495008
57positive regulation of triglyceride lipase activity (GO:0061365)4.33252411
58positive regulation of lipoprotein lipase activity (GO:0051006)4.33252411
59acylglycerol homeostasis (GO:0055090)4.31695180
60triglyceride homeostasis (GO:0070328)4.31695180
61alpha-amino acid catabolic process (GO:1901606)4.29505451
62aromatic amino acid family metabolic process (GO:0009072)4.12227848
63serine family amino acid metabolic process (GO:0009069)4.03548710
64cellular ketone body metabolic process (GO:0046950)4.03222305
65negative regulation of coagulation (GO:0050819)4.03045147
66plasma lipoprotein particle remodeling (GO:0034369)4.01041517
67protein-lipid complex remodeling (GO:0034368)4.01041517
68macromolecular complex remodeling (GO:0034367)4.01041517
69negative regulation of wound healing (GO:0061045)3.98694766
70positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.96733636
71amino-acid betaine metabolic process (GO:0006577)3.93927757
72negative regulation of complement activation (GO:0045916)3.93023291
73flavonoid metabolic process (GO:0009812)3.91036623
74tryptophan metabolic process (GO:0006568)3.80846220
75arginine metabolic process (GO:0006525)3.80596982
76positive regulation of hemostasis (GO:1900048)3.78397670
77positive regulation of blood coagulation (GO:0030194)3.78397670
78cholesterol efflux (GO:0033344)3.75083650
79intestinal cholesterol absorption (GO:0030299)3.72677298
80high-density lipoprotein particle remodeling (GO:0034375)3.66582253
81sodium-independent organic anion transport (GO:0043252)3.65713424
82cellular amino acid catabolic process (GO:0009063)3.65163617
83xenobiotic metabolic process (GO:0006805)3.57527705
84hormone catabolic process (GO:0042447)3.57255953
85ketone body metabolic process (GO:1902224)3.53102390
86response to mercury ion (GO:0046689)3.51307470
87fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.46001213
88positive regulation of coagulation (GO:0050820)3.45898025
89reverse cholesterol transport (GO:0043691)3.43737075
90oxaloacetate metabolic process (GO:0006107)3.43227958
91phospholipid efflux (GO:0033700)3.43204170
92serine family amino acid biosynthetic process (GO:0009070)3.35763755
93regulation of acute inflammatory response (GO:0002673)3.35167243
94cysteine metabolic process (GO:0006534)3.34428937
95positive regulation of lipid catabolic process (GO:0050996)3.32873085
96regulation of apoptotic cell clearance (GO:2000425)3.31352135
97exogenous drug catabolic process (GO:0042738)10.9081825
98omega-hydroxylase P450 pathway (GO:0097267)10.8895569
99epoxygenase P450 pathway (GO:0019373)10.6564465
100drug catabolic process (GO:0042737)10.1567879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse6.78317436
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.50229204
3FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.59490702
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.57678415
5PPARA_22158963_ChIP-Seq_LIVER_Mouse5.42879501
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.25778105
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06424703
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.88978216
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.46745166
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08936940
11FOXA2_19822575_ChIP-Seq_HepG2_Human2.05964998
12HTT_18923047_ChIP-ChIP_STHdh_Human2.00410567
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6242501
14HNF4A_19822575_ChIP-Seq_HepG2_Human1.97570106
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73481405
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63451239
17BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54221967
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50774241
19BCAT_22108803_ChIP-Seq_LS180_Human1.47404572
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.44929909
21ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23486989
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22721096
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13894604
24AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12539464
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.08813714
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04723854
27CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03852661
28DROSHA_22980978_ChIP-Seq_HELA_Human1.02455039
29CBP_21632823_ChIP-Seq_H3396_Human1.01898048
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01577304
31NFYA_21822215_ChIP-Seq_K562_Human0.99496603
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97922882
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97427096
34HNFA_21074721_ChIP-Seq_CACO-2_Human0.96195415
35* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95827791
36IRF8_22096565_ChIP-ChIP_GC-B_Human0.95607963
37GBX2_23144817_ChIP-Seq_PC3_Human0.94828812
38POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93907989
39PHF8_20622853_ChIP-Seq_HELA_Human0.93859563
40AR_20517297_ChIP-Seq_VCAP_Human0.93770706
41ER_23166858_ChIP-Seq_MCF-7_Human0.92486234
42TP53_18474530_ChIP-ChIP_U2OS_Human0.92437881
43IRF1_19129219_ChIP-ChIP_H3396_Human0.90741326
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90067601
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85013944
46GATA4_25053715_ChIP-Seq_YYC3_Human0.84488847
47TCF4_18268006_ChIP-ChIP_LS174T_Human0.81972914
48NFE2_27457419_Chip-Seq_LIVER_Mouse0.79821788
49TRIM28_21343339_ChIP-Seq_HEK293_Human0.79685839
50CEBPB_22108803_ChIP-Seq_LS180_Human0.76775689
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75622771
52GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.75338801
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75120884
54GATA6_21074721_ChIP-Seq_CACO-2_Human0.73810565
55ETV2_25802403_ChIP-Seq_MESCs_Mouse0.73456499
56CDX2_22108803_ChIP-Seq_LS180_Human0.73038830
57ETV1_20927104_ChIP-Seq_GIST48_Human0.72776354
58EZH2_27294783_Chip-Seq_NPCs_Mouse0.72417543
59RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72325126
60TAF15_26573619_Chip-Seq_HEK293_Human0.71724257
61FOXA1_25552417_ChIP-Seq_VCAP_Human0.71576688
62CBX2_22325352_ChIP-Seq_293T-Rex_Human0.70786113
63NFYB_21822215_ChIP-Seq_K562_Human0.70765894
64MYC_19829295_ChIP-Seq_ESCs_Human0.69573061
65KAP1_22055183_ChIP-Seq_ESCs_Mouse0.68959434
66TCF4_22108803_ChIP-Seq_LS180_Human0.67281914
67FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66835964
68SOX2_21211035_ChIP-Seq_LN229_Human0.66678306
69RAC3_21632823_ChIP-Seq_H3396_Human0.66152668
70CDX2_20551321_ChIP-Seq_CACO-2_Human0.66122483
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.66000351
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.65602906
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.65264117
74STAT3_23295773_ChIP-Seq_U87_Human0.64392742
75CTBP1_25329375_ChIP-Seq_LNCAP_Human0.63046663
76SUZ12_27294783_Chip-Seq_NPCs_Mouse0.63035183
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62961829
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62707211
79NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62707211
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.62337872
81PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.61506746
82P53_21459846_ChIP-Seq_SAOS-2_Human0.61011857
83KLF5_20875108_ChIP-Seq_MESCs_Mouse0.60362772
84TBL1_22424771_ChIP-Seq_293T_Human0.60309359
85CBP_20019798_ChIP-Seq_JUKART_Human0.60238502
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.60238502
87ESR2_21235772_ChIP-Seq_MCF-7_Human0.59228072
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58540428
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.58289993
90TAF2_19829295_ChIP-Seq_ESCs_Human0.58081377
91SPI1_20517297_ChIP-Seq_HL60_Human0.57754470
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.57565900
93ERG_20517297_ChIP-Seq_VCAP_Human0.57087143
94WDR5_24793694_ChIP-Seq_LNCAP_Human0.57043105
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.55901998
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.55601724
97RBPJ_21746931_ChIP-Seq_IB4_Human0.55542112
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.55445265
99SMC4_20622854_ChIP-Seq_HELA_Human0.54671634
100TP53_16413492_ChIP-PET_HCT116_Human0.54619360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.77391238
2MP0008875_abnormal_xenobiotic_pharmacok6.41495765
3MP0005085_abnormal_gallbladder_physiolo6.31211015
4MP0005360_urolithiasis5.93488624
5MP0005365_abnormal_bile_salt5.33718352
6MP0003195_calcinosis5.26821580
7MP0003252_abnormal_bile_duct4.39022238
8MP0002138_abnormal_hepatobiliary_system4.37220076
9MP0001666_abnormal_nutrient_absorption3.25446377
10MP0010329_abnormal_lipoprotein_level2.93795710
11MP0003868_abnormal_feces_composition2.72997511
12MP0003191_abnormal_cellular_cholesterol2.58868399
13MP0005332_abnormal_amino_acid2.38482127
14MP0009697_abnormal_copulation2.38020393
15MP0010368_abnormal_lymphatic_system2.35071367
16MP0003806_abnormal_nucleotide_metabolis2.09216157
17MP0000609_abnormal_liver_physiology1.82984689
18MP0005670_abnormal_white_adipose1.70698021
19MP0002118_abnormal_lipid_homeostasis1.69757312
20MP0002876_abnormal_thyroid_physiology1.68911454
21MP0001661_extended_life_span1.53746970
22MP0009840_abnormal_foam_cell1.46276271
23MP0001764_abnormal_homeostasis1.46057356
24MP0009053_abnormal_anal_canal1.41422932
25MP0002132_abnormal_respiratory_system1.27036272
26MP0002282_abnormal_trachea_morphology1.23205964
27MP0003656_abnormal_erythrocyte_physiolo1.23049586
28MP0004019_abnormal_vitamin_homeostasis1.15493784
29MP0002249_abnormal_larynx_morphology1.12243908
30MP0005408_hypopigmentation1.11410832
31MP0005319_abnormal_enzyme/_coenzyme1.09126834
32MP0000598_abnormal_liver_morphology1.05949302
33MP0009764_decreased_sensitivity_to1.05724824
34MP0008872_abnormal_physiological_respon1.04846767
35MP0003879_abnormal_hair_cell0.96429714
36MP0005584_abnormal_enzyme/coenzyme_acti0.91815489
37MP0009643_abnormal_urine_homeostasis0.89635036
38MP0009763_increased_sensitivity_to0.86289385
39MP0002971_abnormal_brown_adipose0.84643003
40MP0005187_abnormal_penis_morphology0.81945631
41MP0009642_abnormal_blood_homeostasis0.81517293
42MP0001915_intracranial_hemorrhage0.77336094
43MP0005376_homeostasis/metabolism_phenot0.77247371
44MP0005266_abnormal_metabolism0.74141039
45MP0008469_abnormal_protein_level0.72285792
46MP0005535_abnormal_body_temperature0.71408559
47MP0005636_abnormal_mineral_homeostasis0.70777077
48MP0002168_other_aberrant_phenotype0.70520728
49MP0005395_other_phenotype0.68937547
50MP0002332_abnormal_exercise_endurance0.66619301
51MP0004130_abnormal_muscle_cell0.65280093
52MP0004782_abnormal_surfactant_physiolog0.63295276
53MP0003690_abnormal_glial_cell0.62795435
54MP0003705_abnormal_hypodermis_morpholog0.61103459
55MP0000604_amyloidosis0.60839286
56MP0008874_decreased_physiological_sensi0.60524432
57MP0005334_abnormal_fat_pad0.59935145
58MP0002078_abnormal_glucose_homeostasis0.58819758
59MP0009765_abnormal_xenobiotic_induced0.52135219
60MP0005464_abnormal_platelet_physiology0.51139202
61MP0003186_abnormal_redox_activity0.49843479
62MP0005377_hearing/vestibular/ear_phenot0.49626917
63MP0003878_abnormal_ear_physiology0.49626917
64MP0005451_abnormal_body_composition0.48721976
65MP0005023_abnormal_wound_healing0.47650012
66MP0009785_altered_susceptibility_to0.43399662
67MP0003011_delayed_dark_adaptation0.42750310
68MP0005166_decreased_susceptibility_to0.42707349
69MP0000566_synostosis0.41343873
70MP0000467_abnormal_esophagus_morphology0.37645633
71MP0003638_abnormal_response/metabolism_0.37107209
72MP0005448_abnormal_energy_balance0.36134786
73MP0000639_abnormal_adrenal_gland0.34807689
74MP0005647_abnormal_sex_gland0.34547229
75MP0000249_abnormal_blood_vessel0.31684575
76MP0002136_abnormal_kidney_physiology0.30998078
77MP0003075_altered_response_to0.29548396
78MP0003953_abnormal_hormone_level0.27008752
79MP0009115_abnormal_fat_cell0.26769111
80MP0004043_abnormal_pH_regulation0.25865637
81MP0005220_abnormal_exocrine_pancreas0.25772632
82MP0004272_abnormal_basement_membrane0.25291226
83MP0005083_abnormal_biliary_tract0.24940934
84MP0006036_abnormal_mitochondrial_physio0.24278140
85MP0006292_abnormal_olfactory_placode0.23116127
86MP0002128_abnormal_blood_circulation0.22195220
87MP0001986_abnormal_taste_sensitivity0.20972215
88MP0001851_eye_inflammation0.20435165
89MP0004883_abnormal_blood_vessel0.19996728
90MP0002295_abnormal_pulmonary_circulatio0.19394515
91MP0005197_abnormal_uvea_morphology0.19032966
92MP0005397_hematopoietic_system_phenotyp0.18327552
93MP0001545_abnormal_hematopoietic_system0.18327552
94MP0005164_abnormal_response_to0.17574621
95MP0002697_abnormal_eye_size0.17397415
96MP0002928_abnormal_bile_duct0.17172183
97MP0003718_maternal_effect0.16885988
98MP0000371_diluted_coat_color0.16745082
99MP0002135_abnormal_kidney_morphology0.15606277
100MP0001756_abnormal_urination0.15578524

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.20502734
2Prolonged partial thromboplastin time (HP:0003645)9.17296157
3Abnormality of aromatic amino acid family metabolism (HP:0004338)8.76878782
4Abnormality of complement system (HP:0005339)8.60436460
5Conjugated hyperbilirubinemia (HP:0002908)7.93782435
6Hypobetalipoproteinemia (HP:0003563)7.29228237
7Joint hemorrhage (HP:0005261)6.38116175
8Hyperlipoproteinemia (HP:0010980)6.31853327
9Systemic lupus erythematosus (HP:0002725)6.26196336
10Intrahepatic cholestasis (HP:0001406)5.56554663
11Glomerulonephritis (HP:0000099)5.43429515
12Recurrent gram-negative bacterial infections (HP:0005420)5.16989845
13Abnormality of pyrimidine metabolism (HP:0004353)5.16769740
14Xanthomatosis (HP:0000991)4.82928562
15Spontaneous abortion (HP:0005268)4.56555790
16Abnormality of the intrinsic pathway (HP:0010989)4.48249132
17Hypolipoproteinemia (HP:0010981)4.34327677
18Abnormality of the common coagulation pathway (HP:0010990)4.19078819
19Nephritis (HP:0000123)4.07060011
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.89479368
21Hypoalphalipoproteinemia (HP:0003233)3.86412734
22Abnormality of methionine metabolism (HP:0010901)3.61362510
23Neonatal hypoglycemia (HP:0001998)3.60731368
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.32209232
25Hyperglycinemia (HP:0002154)3.24765611
26Fair hair (HP:0002286)3.17983386
27Delayed CNS myelination (HP:0002188)3.14033292
28Fat malabsorption (HP:0002630)3.05849400
29Hypercholesterolemia (HP:0003124)2.94063344
30Hyperammonemia (HP:0001987)2.92562537
31Epidermoid cyst (HP:0200040)2.84822707
32Abnormality of glycine metabolism (HP:0010895)2.84053313
33Abnormality of serine family amino acid metabolism (HP:0010894)2.84053313
34Hemorrhage of the eye (HP:0011885)2.78228182
35Mitral stenosis (HP:0001718)2.77255554
36Gingival bleeding (HP:0000225)2.76893894
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72504224
38Hyperbilirubinemia (HP:0002904)2.70672221
39Abnormality of nucleobase metabolism (HP:0010932)2.65926113
40Thrombophlebitis (HP:0004418)2.63866040
41Generalized aminoaciduria (HP:0002909)2.60212825
42Abnormality of serum amino acid levels (HP:0003112)2.56906217
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.55616120
44Osteomalacia (HP:0002749)2.53644752
45Hepatocellular carcinoma (HP:0001402)2.51146959
46Vascular calcification (HP:0004934)2.39612624
47Rickets (HP:0002748)2.37603728
48Hyperglycinuria (HP:0003108)2.30153885
49Menorrhagia (HP:0000132)2.26352779
50Generalized hypopigmentation of hair (HP:0011358)2.25083981
51Purpura (HP:0000979)2.23917016
52Pulmonary embolism (HP:0002204)2.22523817
53Cholelithiasis (HP:0001081)2.20887274
54Ketosis (HP:0001946)2.13955080
55Cardiovascular calcification (HP:0011915)2.12638320
56Steatorrhea (HP:0002570)2.11570518
57Elevated alkaline phosphatase (HP:0003155)2.06540497
58Abnormal gallbladder morphology (HP:0012437)2.04843092
59Blue irides (HP:0000635)2.03874857
60Complement deficiency (HP:0004431)10.7029221
61Abnormality of monocarboxylic acid metabolism (HP:0010996)10.4813972
62Metabolic acidosis (HP:0001942)1.97260328
63Enlarged kidneys (HP:0000105)1.95886861
64Arthropathy (HP:0003040)1.93947038
65Hypophosphatemic rickets (HP:0004912)1.91418760
66Abnormal enzyme/coenzyme activity (HP:0012379)1.88998016
67Abnormality of alkaline phosphatase activity (HP:0004379)1.85962667
68Myocardial infarction (HP:0001658)1.83971369
69Increased mean platelet volume (HP:0011877)1.80804130
70Cerebral palsy (HP:0100021)1.76499706
71Impaired platelet aggregation (HP:0003540)1.72135104
72Abnormal platelet function (HP:0011869)1.72135104
73Skin nodule (HP:0200036)1.71988958
74Joint swelling (HP:0001386)1.70817381
75Reduced antithrombin III activity (HP:0001976)1.70202559
76Epistaxis (HP:0000421)1.69118826
77Increased serum ferritin (HP:0003281)1.68101043
78Hypochromic microcytic anemia (HP:0004840)1.66370574
79Hyperphosphaturia (HP:0003109)1.66310630
80Cholecystitis (HP:0001082)1.66196613
81Abnormal gallbladder physiology (HP:0012438)1.66196613
82Poikilocytosis (HP:0004447)1.65689577
83Abnormality of vitamin metabolism (HP:0100508)1.65553937
84Abnormal platelet volume (HP:0011876)1.62711523
85Abnormality of iron homeostasis (HP:0011031)1.61973962
86Irritability (HP:0000737)1.60104639
87Reticulocytosis (HP:0001923)1.55101448
88Esophageal varix (HP:0002040)1.54850645
89Atrioventricular block (HP:0001678)1.54422066
90Abnormality of the Achilles tendon (HP:0005109)1.53578362
91Glycosuria (HP:0003076)1.53233999
92Abnormality of urine glucose concentration (HP:0011016)1.53233999
93Gangrene (HP:0100758)1.52527974
94Gout (HP:0001997)1.51930272
95Bifid scrotum (HP:0000048)1.51687965
96Abnormality of purine metabolism (HP:0004352)1.50956118
97Abnormality of transition element cation homeostasis (HP:0011030)1.50716652
98Abnormal biliary tract physiology (HP:0012439)1.49787911
99Bile duct proliferation (HP:0001408)1.49787911
100Abnormal delivery (HP:0001787)1.48984408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.15264519
2PIK3CG4.14963967
3MST1R3.78502921
4ACVR1B3.76064590
5SIK13.23732817
6FGFR43.22382219
7FRK2.83840749
8WNK42.47325624
9TRIB32.47064434
10PKN22.20076049
11TYK22.19613874
12BMPR1B2.14339883
13NTRK31.97081047
14RIPK11.87798267
15PRKAA21.86877858
16PRKACG1.84447920
17PIK3CA1.82066765
18MET1.79449455
19BCKDK1.73614542
20TNK21.69699840
21TIE11.68632313
22TAOK31.68246164
23EPHA31.65042937
24INSRR1.64431316
25AKT31.54851140
26MAP2K41.51859056
27NLK1.49768853
28MAPK111.42104029
29IGF1R1.36003986
30FER1.35851867
31ERBB21.34448015
32JAK11.29299668
33PRKCG1.15759031
34CSF1R1.14100237
35RET0.93644159
36TNIK0.93473264
37PDPK10.91875620
38FGFR30.91223749
39PDK10.87898814
40JAK20.87245948
41PRPF4B0.87029457
42BLK0.86764506
43MAP3K130.85974440
44PDK20.84154203
45PRKAA10.84037802
46MAP3K30.83317271
47PRKACA0.79100466
48PRKG10.78123527
49PRKCZ0.78123439
50ICK0.77884191
51MELK0.76141619
52MUSK0.74381163
53DAPK20.71254631
54NME10.69223929
55FLT30.66514712
56TGFBR10.66511189
57TGFBR20.66136397
58SGK20.64712453
59MAPK70.63715808
60PRKACB0.62852882
61KDR0.61460300
62EPHB10.60112963
63CAMK1D0.58817264
64SGK10.58687876
65EPHA40.58567391
66MAP4K20.57072587
67RPS6KA30.52451640
68MAP3K70.51750718
69MAP2K60.50978597
70MAP3K60.50743981
71LATS10.50483712
72MAP3K10.47477292
73PRKCB0.46655779
74MAPK120.45650674
75MTOR0.45304436
76SGK2230.44869234
77SGK4940.44869234
78NEK90.44839516
79PRKCA0.44295688
80SGK30.43991783
81KIT0.41202324
82CAMKK20.41018386
83ADRBK10.40621098
84NEK10.38367088
85SRC0.37694398
86MAPK40.35450164
87CSNK1D0.35201788
88CAMK40.35010145
89CSNK1E0.34609018
90MYLK0.34310049
91CAMKK10.32881272
92MAPK30.32293134
93WNK10.31858288
94NTRK10.31767966
95MAP2K10.30465324
96GSK3A0.29707905
97WNK30.29626086
98CSNK1A10.29086654
99MAPK10.27536342
100CAMK1G0.26332435

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.69304347
2Caffeine metabolism_Homo sapiens_hsa002324.64817843
3Complement and coagulation cascades_Homo sapiens_hsa046103.90033213
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.66922660
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.57434797
6Retinol metabolism_Homo sapiens_hsa008303.43408929
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10903312
8Chemical carcinogenesis_Homo sapiens_hsa052042.93270603
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.87965666
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.76460806
11Fatty acid degradation_Homo sapiens_hsa000712.67352068
12Arginine biosynthesis_Homo sapiens_hsa002202.59572359
13Tyrosine metabolism_Homo sapiens_hsa003502.54235991
14Phenylalanine metabolism_Homo sapiens_hsa003602.53874276
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.42773413
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.35033022
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.29248741
18Histidine metabolism_Homo sapiens_hsa003402.15732648
19Linoleic acid metabolism_Homo sapiens_hsa005912.12515390
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03155946
21Butanoate metabolism_Homo sapiens_hsa006501.92241994
22Tryptophan metabolism_Homo sapiens_hsa003801.90438582
23Bile secretion_Homo sapiens_hsa049761.70824326
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.56268239
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55427950
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53877045
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43144875
28Starch and sucrose metabolism_Homo sapiens_hsa005001.41709842
29Staphylococcus aureus infection_Homo sapiens_hsa051501.38928153
30Prion diseases_Homo sapiens_hsa050201.38815978
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.31710724
32PPAR signaling pathway_Homo sapiens_hsa033201.30791309
33Arachidonic acid metabolism_Homo sapiens_hsa005901.27182513
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.26691003
35beta-Alanine metabolism_Homo sapiens_hsa004101.19264680
36Vitamin B6 metabolism_Homo sapiens_hsa007501.18828698
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17312239
38Biosynthesis of amino acids_Homo sapiens_hsa012301.15027745
39Peroxisome_Homo sapiens_hsa041461.11956273
40ABC transporters_Homo sapiens_hsa020101.00217759
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99240769
42Pyruvate metabolism_Homo sapiens_hsa006200.97090753
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96567646
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92632430
45One carbon pool by folate_Homo sapiens_hsa006700.90066193
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85131987
47Arginine and proline metabolism_Homo sapiens_hsa003300.84766217
48Propanoate metabolism_Homo sapiens_hsa006400.76716812
49Carbon metabolism_Homo sapiens_hsa012000.75652432
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71951061
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66398170
52Fat digestion and absorption_Homo sapiens_hsa049750.62193274
53Fatty acid metabolism_Homo sapiens_hsa012120.61522293
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52636049
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.47792466
56Lysine degradation_Homo sapiens_hsa003100.45820417
57Metabolic pathways_Homo sapiens_hsa011000.40181001
58Pertussis_Homo sapiens_hsa051330.32271104
59Glycerolipid metabolism_Homo sapiens_hsa005610.29907403
60Sulfur metabolism_Homo sapiens_hsa009200.27551034
61Insulin resistance_Homo sapiens_hsa049310.27407864
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23919979
63Glucagon signaling pathway_Homo sapiens_hsa049220.23428303
64Systemic lupus erythematosus_Homo sapiens_hsa053220.20990064
65Sulfur relay system_Homo sapiens_hsa041220.18984192
66Fructose and mannose metabolism_Homo sapiens_hsa000510.15717718
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14008955
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.12049332
69Pentose phosphate pathway_Homo sapiens_hsa000300.11451206
70Amoebiasis_Homo sapiens_hsa051460.10776116
71Serotonergic synapse_Homo sapiens_hsa047260.07206567
72AMPK signaling pathway_Homo sapiens_hsa041520.04749238
73Fatty acid biosynthesis_Homo sapiens_hsa000610.04431566
74Mineral absorption_Homo sapiens_hsa049780.00832607
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.00344574
76GABAergic synapse_Homo sapiens_hsa04727-0.2699278
77ECM-receptor interaction_Homo sapiens_hsa04512-0.2678515
78Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2633028
79Protein digestion and absorption_Homo sapiens_hsa04974-0.2520769
80Type II diabetes mellitus_Homo sapiens_hsa04930-0.2376657
81Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2188159
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.2131156
83Circadian rhythm_Homo sapiens_hsa04710-0.1972238
84Insulin signaling pathway_Homo sapiens_hsa04910-0.1356531
85Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1299010
86Steroid biosynthesis_Homo sapiens_hsa00100-0.1272374
87Folate biosynthesis_Homo sapiens_hsa00790-0.1169701
88Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1155948
89Renin-angiotensin system_Homo sapiens_hsa04614-0.1108844
90Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1106805
91African trypanosomiasis_Homo sapiens_hsa05143-0.1010998
92Other glycan degradation_Homo sapiens_hsa00511-0.0967490
93Galactose metabolism_Homo sapiens_hsa00052-0.0960937
94Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0838238
95Fatty acid elongation_Homo sapiens_hsa00062-0.0642934
96Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0574781
97Nitrogen metabolism_Homo sapiens_hsa00910-0.0547961
98Glutathione metabolism_Homo sapiens_hsa00480-0.0362784
99Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0216855
100Selenocompound metabolism_Homo sapiens_hsa00450-0.0101137

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