LPAR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.51213037
2* axon ensheathment (GO:0008366)7.13304353
3* ensheathment of neurons (GO:0007272)7.13304353
4* myelination (GO:0042552)7.09659262
5long-chain fatty acid biosynthetic process (GO:0042759)5.80574354
6negative regulation of neurotransmitter secretion (GO:0046929)5.40067187
7myelin maintenance (GO:0043217)5.31371787
8oligodendrocyte differentiation (GO:0048709)4.97850503
9cholesterol biosynthetic process (GO:0006695)4.81759983
10negative regulation of neurotransmitter transport (GO:0051589)4.72113878
11apical protein localization (GO:0045176)4.70869289
12asymmetric protein localization (GO:0008105)4.58485321
13astrocyte development (GO:0014002)4.52567610
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.48937736
15photoreceptor cell differentiation (GO:0046530)4.43017631
16eye photoreceptor cell differentiation (GO:0001754)4.43017631
17myelination in peripheral nervous system (GO:0022011)4.42819221
18peripheral nervous system axon ensheathment (GO:0032292)4.42819221
19adhesion of symbiont to host cell (GO:0044650)4.33033784
20virion attachment to host cell (GO:0019062)4.33033784
21glycerophospholipid catabolic process (GO:0046475)4.29429193
22negative regulation of protein localization to cell surface (GO:2000009)4.26507082
23protein heterotrimerization (GO:0070208)4.25849552
24sterol biosynthetic process (GO:0016126)4.23001580
25regulation of collateral sprouting (GO:0048670)4.21247402
26collagen fibril organization (GO:0030199)4.15332083
27response to redox state (GO:0051775)4.11743059
28creatine metabolic process (GO:0006600)4.06245211
29establishment of mitochondrion localization (GO:0051654)4.05748455
30skin morphogenesis (GO:0043589)4.01159872
31sequestering of extracellular ligand from receptor (GO:0035581)3.97787084
32chondrocyte proliferation (GO:0035988)3.96425829
33limb bud formation (GO:0060174)3.93516462
34substantia nigra development (GO:0021762)3.85664007
35isoprenoid biosynthetic process (GO:0008299)3.75839245
36type B pancreatic cell proliferation (GO:0044342)3.75097500
37glutamate secretion (GO:0014047)3.73159068
38import into cell (GO:0098657)3.72907789
39presynaptic membrane organization (GO:0097090)3.70439708
40kidney mesenchyme development (GO:0072074)3.68487298
41presynaptic membrane assembly (GO:0097105)3.64394399
42response to lipoprotein particle (GO:0055094)3.61762438
43positive regulation of oligodendrocyte differentiation (GO:0048714)3.61315395
44negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.61262546
45long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.55054554
46regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.53544325
47negative regulation of JUN kinase activity (GO:0043508)3.53377418
48mesenchymal-epithelial cell signaling (GO:0060638)3.53100381
49cell migration involved in heart development (GO:0060973)3.50457583
50cellular potassium ion homeostasis (GO:0030007)3.44799352
51amyloid precursor protein metabolic process (GO:0042982)3.43931141
52metanephric mesenchyme development (GO:0072075)3.43553895
53endodermal cell differentiation (GO:0035987)3.42793848
54positive regulation of action potential (GO:0045760)3.40705388
55L-amino acid import (GO:0043092)3.39488385
56positive regulation of fibroblast migration (GO:0010763)3.37773063
57response to methylmercury (GO:0051597)3.37583081
58interleukin-6-mediated signaling pathway (GO:0070102)3.36662324
59extracellular fibril organization (GO:0043206)3.31199765
60peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.30862295
61peptidyl-tyrosine autophosphorylation (GO:0038083)3.27735178
62lateral sprouting from an epithelium (GO:0060601)3.27522915
63peripheral nervous system development (GO:0007422)3.26773467
64long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.25361015
65leukocyte migration involved in inflammatory response (GO:0002523)3.18775389
66cerebral cortex radially oriented cell migration (GO:0021799)3.17260553
67regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.16018711
68adhesion of symbiont to host (GO:0044406)3.13373625
69magnesium ion transport (GO:0015693)3.13319640
70protein palmitoylation (GO:0018345)3.11362931
71glycosylceramide metabolic process (GO:0006677)3.10145059
72GPI anchor biosynthetic process (GO:0006506)3.09946709
73negative regulation of axonogenesis (GO:0050771)3.07679706
74dermatan sulfate biosynthetic process (GO:0030208)3.07123355
75cortical actin cytoskeleton organization (GO:0030866)3.06810660
76negative regulation of myoblast differentiation (GO:0045662)3.06547781
77glial cell development (GO:0021782)3.05597918
78endocardial cushion development (GO:0003197)3.03359214
79fatty-acyl-CoA biosynthetic process (GO:0046949)2.99605655
80axon development (GO:0061564)2.99279849
81membrane tubulation (GO:0097320)2.99267576
82cell adhesion mediated by integrin (GO:0033627)2.98345327
83nucleotide transmembrane transport (GO:1901679)2.97488460
84GPI anchor metabolic process (GO:0006505)2.97328841
85regulation of short-term neuronal synaptic plasticity (GO:0048172)2.97133062
86enteric nervous system development (GO:0048484)2.92703806
87collagen metabolic process (GO:0032963)2.92319626
88regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.91513836
89sodium ion export (GO:0071436)2.91014802
90dermatan sulfate metabolic process (GO:0030205)2.89664985
91barbed-end actin filament capping (GO:0051016)2.89663538
92fibril organization (GO:0097435)2.86674424
93cellular response to vitamin (GO:0071295)2.82942553
94Leydig cell differentiation (GO:0033327)2.82783764
95negative regulation of smooth muscle cell migration (GO:0014912)2.82724466
96preassembly of GPI anchor in ER membrane (GO:0016254)2.81765100
97cortical cytoskeleton organization (GO:0030865)2.81060331
98Golgi to plasma membrane protein transport (GO:0043001)2.80352903
99myelin assembly (GO:0032288)2.79001878
100collagen catabolic process (GO:0030574)2.78714404
101amino acid import (GO:0043090)2.78426085
102cellular response to epinephrine stimulus (GO:0071872)2.78332100
103bone trabecula formation (GO:0060346)2.77787954
104membrane assembly (GO:0071709)2.76590788
105transmission of nerve impulse (GO:0019226)2.75407180
106cellular response to hepatocyte growth factor stimulus (GO:0035729)2.74291522
107response to hepatocyte growth factor (GO:0035728)2.74291522
108synaptic vesicle maturation (GO:0016188)2.73349140
109multicellular organismal macromolecule metabolic process (GO:0044259)2.72389436
110positive regulation of glial cell differentiation (GO:0045687)2.72275814
111membrane raft organization (GO:0031579)2.72228135
112cytoskeletal anchoring at plasma membrane (GO:0007016)2.71878733
113fatty-acyl-CoA metabolic process (GO:0035337)2.70271576
114prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.68948565
115histone H2B ubiquitination (GO:0033523)2.68822660
116protein targeting to plasma membrane (GO:0072661)2.67860484
117hemidesmosome assembly (GO:0031581)2.66600333
118response to gravity (GO:0009629)2.66385812
119glial cell differentiation (GO:0010001)2.65875010
120positive regulation of actin filament depolymerization (GO:0030836)2.65340149
121negative regulation of axon extension (GO:0030517)2.65227474
122cell-substrate junction assembly (GO:0007044)2.65220886
123adult walking behavior (GO:0007628)2.64999331
124regulation of extracellular matrix disassembly (GO:0010715)2.64513816
125negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64293938
126protein localization to endosome (GO:0036010)2.64118351
127microtubule polymerization or depolymerization (GO:0031109)2.63412564
128protein retention in ER lumen (GO:0006621)2.63374207
129apoptotic cell clearance (GO:0043277)2.63074769
130regulation of lipoprotein metabolic process (GO:0050746)2.63018002
131protein neddylation (GO:0045116)2.61830150
132organ growth (GO:0035265)2.61536531
133substrate-dependent cell migration (GO:0006929)2.60589051
134heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.58128344
135multicellular organismal metabolic process (GO:0044236)2.57286019
136neural nucleus development (GO:0048857)2.57264330
137multicellular organismal catabolic process (GO:0044243)2.56345084
138very long-chain fatty acid metabolic process (GO:0000038)2.54489051
139maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54264419
140smooth muscle tissue development (GO:0048745)2.54159926
141negative regulation of BMP signaling pathway (GO:0030514)2.53808871
142hypotonic response (GO:0006971)2.52396719
143otic vesicle formation (GO:0030916)2.51803246
144negative regulation of osteoblast proliferation (GO:0033689)2.49722731
145ear development (GO:0043583)2.48832997
146positive regulation of gliogenesis (GO:0014015)2.47628790
147protein localization to cell surface (GO:0034394)2.47085205
148regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.45591197
149stress fiber assembly (GO:0043149)2.45161180
150cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.45009329
151cranial nerve development (GO:0021545)2.44810928
152response to epinephrine (GO:0071871)2.44427119
153extracellular matrix assembly (GO:0085029)2.44253672
154extracellular matrix disassembly (GO:0022617)2.43293547
155extracellular negative regulation of signal transduction (GO:1900116)2.42775309
156extracellular regulation of signal transduction (GO:1900115)2.42775309
157regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.41970579
158synaptic vesicle exocytosis (GO:0016079)2.40740058
159positive regulation of extracellular matrix organization (GO:1903055)2.40671471
160extracellular matrix organization (GO:0030198)2.40573806
161peptidyl-cysteine modification (GO:0018198)2.40482563
162response to lead ion (GO:0010288)2.39995457
163positive regulation of axon extension (GO:0045773)2.39825847
164regulation of somitogenesis (GO:0014807)2.39674504
165extracellular structure organization (GO:0043062)2.39573369
166negative regulation of leukocyte chemotaxis (GO:0002689)2.38487746
167regulation of integrin-mediated signaling pathway (GO:2001044)2.36330498
168vascular endothelial growth factor signaling pathway (GO:0038084)2.35895077
169actin filament depolymerization (GO:0030042)2.35750784
170substrate adhesion-dependent cell spreading (GO:0034446)2.35043318
171blood vessel maturation (GO:0001955)2.34752162
172negative regulation of axon extension involved in axon guidance (GO:0048843)2.32915435
173neuronal ion channel clustering (GO:0045161)2.32418818
174regulation of axon extension involved in axon guidance (GO:0048841)2.30503389
175muscle cell migration (GO:0014812)2.28808333
176axon extension (GO:0048675)2.27357544
177regulation of glomerular filtration (GO:0003093)2.26972197
178heparan sulfate proteoglycan metabolic process (GO:0030201)2.26808241
179membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.26603146
180potassium ion homeostasis (GO:0055075)2.26025231
181cellular response to vitamin D (GO:0071305)2.24659000
182positive regulation of blood vessel endothelial cell migration (GO:0043536)2.24620602
183adherens junction assembly (GO:0034333)2.23175340
184axon ensheathment in central nervous system (GO:0032291)10.9515787
185central nervous system myelination (GO:0022010)10.9515787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.22029697
2RARG_19884340_ChIP-ChIP_MEFs_Mouse2.93948608
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.81382414
4SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.76468400
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.38816345
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34344157
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26385598
8OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.18382047
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16785883
10TAF15_26573619_Chip-Seq_HEK293_Human2.13456783
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.12947112
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.11276177
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.10835526
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10262872
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.10060101
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05928350
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04470815
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00749906
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00749906
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00546160
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98800765
22* BRD4_25478319_ChIP-Seq_HGPS_Human1.94993964
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91932545
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.86308620
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86108928
26AR_21572438_ChIP-Seq_LNCaP_Human1.83249619
27TP53_16413492_ChIP-PET_HCT116_Human1.81831439
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81164464
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80625089
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.80237527
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79582701
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.78998881
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77380919
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72384609
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.66496826
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.66117784
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64561891
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63616587
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.62321310
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.62321310
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.62219338
42* ER_23166858_ChIP-Seq_MCF-7_Human1.61163035
43VDR_22108803_ChIP-Seq_LS180_Human1.60730895
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60402000
45* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58494185
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56946590
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54750130
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54506533
49FUS_26573619_Chip-Seq_HEK293_Human1.54042644
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.52658831
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.48909312
52TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48203620
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.47949055
54* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.47012453
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46243960
56* PIAS1_25552417_ChIP-Seq_VCAP_Human1.46233144
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45556791
58CLOCK_20551151_ChIP-Seq_293T_Human1.44407072
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42864280
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39614138
61EZH2_22144423_ChIP-Seq_EOC_Human1.37212817
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36474454
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36471057
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36113037
65SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.33284451
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31297197
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31166527
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30759640
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30380338
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29015683
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.27952530
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27294431
73* P300_19829295_ChIP-Seq_ESCs_Human1.27288517
74* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24287780
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22170035
76TP53_23651856_ChIP-Seq_MEFs_Mouse1.21311904
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20005821
78* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18683521
79DROSHA_22980978_ChIP-Seq_HELA_Human1.18248698
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17598402
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17338029
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17016461
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14662330
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14058615
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.13947181
86RNF2_27304074_Chip-Seq_NSC_Mouse1.12720633
87* STAT3_23295773_ChIP-Seq_U87_Human1.12291175
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10740455
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.10630827
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10497051
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.10466052
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10104412
93EOMES_21245162_ChIP-Seq_HESCs_Human1.09381139
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08755055
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08303760
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07146503
97* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07062580
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06867248
99AHR_22903824_ChIP-Seq_MCF-7_Human1.06741993
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04853481
101* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04536271
102ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04381781
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03761823
104TBX20_22328084_ChIP-Seq_HEART_Mouse1.03444739
105TBX20_22080862_ChIP-Seq_HEART_Mouse1.03444739
106* CMYC_18555785_Chip-Seq_ESCs_Mouse1.03387051
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.02993402
108* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02351954
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01588894
110KDM2B_26808549_Chip-Seq_K562_Human1.01234254
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.00488968
112* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00133639
113P300_18555785_Chip-Seq_ESCs_Mouse1.00044862
114TET1_21490601_ChIP-Seq_MESCs_Mouse1.00007390
115TP53_18474530_ChIP-ChIP_U2OS_Human0.99900062
116CJUN_26792858_Chip-Seq_BT549_Human0.99805145
117* SA1_22415368_ChIP-Seq_MEFs_Mouse0.99762387
118LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99310786
119* SMAD4_21799915_ChIP-Seq_A2780_Human0.99091817
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98711430
121SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98327643
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98083774
123TCF4_23295773_ChIP-Seq_U87_Human0.97774798
124* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97556730
125WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97511584
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96984771
127* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96965958
128TBL1_22424771_ChIP-Seq_293T_Human0.96145692
129SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95989098
130EWS_26573619_Chip-Seq_HEK293_Human0.95852377
131KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95145060
132KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95145060
133KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95145060
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95063378
135* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95057367
136CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94995275
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93762369
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93040392
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92701079
140SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92517927
141TP53_22127205_ChIP-Seq_IMR90_Human0.92429158
142RARB_27405468_Chip-Seq_BRAIN_Mouse0.92230799
143* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92049899
144UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91346102
145GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91261368
146NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90500031
147ESR1_20079471_ChIP-ChIP_T-47D_Human0.90497631
148ISL1_27105846_Chip-Seq_CPCs_Mouse0.90137057
149SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89995669
150SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89995669
151ELK3_25401928_ChIP-Seq_HUVEC_Human0.89118454
152PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88734676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.45214911
2MP0003950_abnormal_plasma_membrane4.35485238
3MP0003705_abnormal_hypodermis_morpholog4.18490925
4MP0008438_abnormal_cutaneous_collagen4.00612684
5MP0003279_aneurysm3.50709901
6MP0005171_absent_coat_pigmentation3.03676426
7MP0009780_abnormal_chondrocyte_physiolo2.93240801
8MP0004270_analgesia2.90894520
9MP0003690_abnormal_glial_cell2.90846817
10MP0005503_abnormal_tendon_morphology2.68064223
11MP0004885_abnormal_endolymph2.56279477
12MP0003136_yellow_coat_color2.54886503
13MP0003880_abnormal_central_pattern2.54737534
14MP0005257_abnormal_intraocular_pressure2.53107625
15MP0006054_spinal_hemorrhage2.38546410
16MP0004742_abnormal_vestibular_system2.18389497
17* MP0003634_abnormal_glial_cell2.16836052
18MP0004134_abnormal_chest_morphology2.10930812
19MP0001529_abnormal_vocalization2.05605046
20MP0000751_myopathy2.03140260
21MP0001485_abnormal_pinna_reflex2.02151505
22MP0000778_abnormal_nervous_system2.02033017
23MP0003329_amyloid_beta_deposits1.99740406
24MP0005409_darkened_coat_color1.96997049
25MP0003566_abnormal_cell_adhesion1.92232251
26MP0005451_abnormal_body_composition1.90199439
27MP0002272_abnormal_nervous_system1.90163218
28MP0009250_abnormal_appendicular_skeleto1.86528337
29MP0005023_abnormal_wound_healing1.84073013
30MP0000566_synostosis1.78311390
31MP0001486_abnormal_startle_reflex1.76801156
32MP0000462_abnormal_digestive_system1.73708736
33MP0010386_abnormal_urinary_bladder1.73290624
34MP0003091_abnormal_cell_migration1.71704097
35MP0000383_abnormal_hair_follicle1.68031347
36MP0003632_abnormal_nervous_system1.66717908
37MP0010368_abnormal_lymphatic_system1.66210496
38MP0003937_abnormal_limbs/digits/tail_de1.65710084
39MP0004142_abnormal_muscle_tone1.61131499
40* MP0001905_abnormal_dopamine_level1.60291347
41MP0010678_abnormal_skin_adnexa1.59524399
42MP0005623_abnormal_meninges_morphology1.57976462
43MP0005410_abnormal_fertilization1.54585687
44MP0000767_abnormal_smooth_muscle1.53387288
45MP0001346_abnormal_lacrimal_gland1.51284393
46MP0002896_abnormal_bone_mineralization1.49897920
47MP0004272_abnormal_basement_membrane1.49778214
48MP0000762_abnormal_tongue_morphology1.49708800
49MP0002229_neurodegeneration1.49428094
50MP0002108_abnormal_muscle_morphology1.41236212
51MP0002064_seizures1.41048714
52MP0005595_abnormal_vascular_smooth1.40947172
53MP0002060_abnormal_skin_morphology1.40583945
54MP0005275_abnormal_skin_tensile1.39136141
55MP0000013_abnormal_adipose_tissue1.38729487
56MP0002734_abnormal_mechanical_nocicepti1.37432009
57MP0004145_abnormal_muscle_electrophysio1.36139552
58MP0003385_abnormal_body_wall1.29003063
59MP0003938_abnormal_ear_development1.28704808
60MP0000955_abnormal_spinal_cord1.28259527
61MP0002295_abnormal_pulmonary_circulatio1.24009380
62MP0004858_abnormal_nervous_system1.20083077
63MP0002938_white_spotting1.19747060
64MP0001177_atelectasis1.18753316
65MP0001243_abnormal_dermal_layer1.18438252
66MP0001963_abnormal_hearing_physiology1.16178190
67MP0009384_cardiac_valve_regurgitation1.15597735
68MP0002882_abnormal_neuron_morphology1.15116932
69MP0009046_muscle_twitch1.13668446
70MP0005508_abnormal_skeleton_morphology1.13490006
71* MP0001299_abnormal_eye_distance/1.12326524
72MP0000747_muscle_weakness1.12314230
73MP0003806_abnormal_nucleotide_metabolis1.12155123
74MP0003755_abnormal_palate_morphology1.10642109
75MP0004859_abnormal_synaptic_plasticity1.10374442
76MP0004381_abnormal_hair_follicle1.10248747
77MP0001958_emphysema1.09410831
78MP0003942_abnormal_urinary_system1.04295521
79MP0010352_gastrointestinal_tract_polyps1.04241093
80MP0003191_abnormal_cellular_cholesterol1.02769072
81MP0004147_increased_porphyrin_level1.02435301
82MP0003631_nervous_system_phenotype1.01489424
83* MP0002752_abnormal_somatic_nervous1.01382237
84MP0001661_extended_life_span0.99241685
85MP0000026_abnormal_inner_ear0.97521093
86MP0008260_abnormal_autophagy0.96319460
87MP0002933_joint_inflammation0.95164641
88MP0002133_abnormal_respiratory_system0.93977565
89MP0005388_respiratory_system_phenotype0.93977565
90MP0000647_abnormal_sebaceous_gland0.92316446
91MP0005390_skeleton_phenotype0.91819671
92MP0000604_amyloidosis0.91817605
93MP0000467_abnormal_esophagus_morphology0.91583405
94MP0003941_abnormal_skin_development0.90814922
95MP0000759_abnormal_skeletal_muscle0.89413375
96MP0003195_calcinosis0.89208277
97* MP0002066_abnormal_motor_capabilities/c0.89057635
98MP0009745_abnormal_behavioral_response0.87212361
99MP0010030_abnormal_orbit_morphology0.86717341
100* MP0000428_abnormal_craniofacial_morphol0.86241866
101MP0001348_abnormal_lacrimal_gland0.85888817
102MP0005164_abnormal_response_to0.85815095
103MP0000537_abnormal_urethra_morphology0.85616302
104MP0003633_abnormal_nervous_system0.85606280
105MP0001849_ear_inflammation0.84029132
106MP0001851_eye_inflammation0.83650148
107MP0005551_abnormal_eye_electrophysiolog0.83369385
108MP0008569_lethality_at_weaning0.83220107
109MP0001340_abnormal_eyelid_morphology0.82324342
110MP0003879_abnormal_hair_cell0.82098919
111MP0002063_abnormal_learning/memory/cond0.81888994
112MP0004043_abnormal_pH_regulation0.81399969
113MP0001542_abnormal_bone_strength0.81272572
114MP0000003_abnormal_adipose_tissue0.80566240
115MP0003045_fibrosis0.80359113
116MP0000534_abnormal_ureter_morphology0.78714247
117MP0005195_abnormal_posterior_eye0.78605802
118MP0002998_abnormal_bone_remodeling0.78225963
119MP0000749_muscle_degeneration0.78219410
120MP0000733_abnormal_muscle_development0.78073732
121MP0000579_abnormal_nail_morphology0.77866520
122MP0005423_abnormal_somatic_nervous0.77388431
123MP0002877_abnormal_melanocyte_morpholog0.76257323
124MP0005386_behavior/neurological_phenoty0.75893281
125MP0004924_abnormal_behavior0.75893281
126* MP0003635_abnormal_synaptic_transmissio0.75121031
127MP0002115_abnormal_skeleton_extremities0.74910089
128MP0001970_abnormal_pain_threshold0.73880854
129MP0004133_heterotaxia0.73303150
130MP0002067_abnormal_sensory_capabilities0.73007828
131MP0004510_myositis0.71868231
132MP0001440_abnormal_grooming_behavior0.71552939
133MP0000372_irregular_coat_pigmentation0.70718587
134MP0002089_abnormal_postnatal_growth/wei0.69909257
135MP0000163_abnormal_cartilage_morphology0.69154305
136MP0002282_abnormal_trachea_morphology0.69139873
137MP0003283_abnormal_digestive_organ0.68911262
138MP0005408_hypopigmentation0.68590683
139MP0005165_increased_susceptibility_to0.68430387
140MP0009053_abnormal_anal_canal0.67190505
141MP0003075_altered_response_to0.67190285
142MP0004036_abnormal_muscle_relaxation0.67181218
143MP0000750_abnormal_muscle_regeneration0.63846483
144MP0009840_abnormal_foam_cell0.63628497
145MP0002572_abnormal_emotion/affect_behav0.60738908
146MP0003115_abnormal_respiratory_system0.60575731
147MP0002168_other_aberrant_phenotype0.60099711
148MP0000569_abnormal_digit_pigmentation0.59873353
149MP0002113_abnormal_skeleton_development0.59327395
150MP0002733_abnormal_thermal_nociception0.58229943
151MP0002735_abnormal_chemical_nociception0.57873575

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.54944387
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.09312712
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.09312712
4Neurofibrillary tangles (HP:0002185)5.20333760
5Aortic aneurysm (HP:0004942)4.89799793
6Aortic dissection (HP:0002647)4.68196797
7Sensory axonal neuropathy (HP:0003390)4.66475487
8Vascular tortuosity (HP:0004948)4.57670768
9Parakeratosis (HP:0001036)4.40069443
10Ankle contracture (HP:0006466)4.35400166
11Abnormality of the corticospinal tract (HP:0002492)4.28307026
12Follicular hyperkeratosis (HP:0007502)4.28208038
13Type 1 muscle fiber predominance (HP:0003803)4.06444577
14Arterial tortuosity (HP:0005116)3.99405274
15Atrophic scars (HP:0001075)3.88975159
16Bladder diverticulum (HP:0000015)3.77007368
17Shallow orbits (HP:0000586)3.74874427
18Peripheral hypomyelination (HP:0007182)3.60164181
19Soft skin (HP:0000977)3.59311916
20Onion bulb formation (HP:0003383)3.51908332
21Cerebral inclusion bodies (HP:0100314)3.50838249
22Neonatal short-limb short stature (HP:0008921)3.44932138
23Slender build (HP:0001533)3.42053425
24Termporal pattern (HP:0011008)3.39345941
25Insidious onset (HP:0003587)3.39345941
26Spinal rigidity (HP:0003306)3.33050389
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.30796464
28Premature rupture of membranes (HP:0001788)3.27678468
29Abnormal auditory evoked potentials (HP:0006958)3.25247175
30Alacrima (HP:0000522)3.23879761
31Cerebral hypomyelination (HP:0006808)3.23435445
32Cervical subluxation (HP:0003308)3.16727701
33Fragile skin (HP:0001030)3.11929920
34Spondylolisthesis (HP:0003302)3.03461321
35Hypoplastic pelvis (HP:0008839)3.02945251
36Genu recurvatum (HP:0002816)2.99017106
37Premature skin wrinkling (HP:0100678)2.95453799
38Dilatation of the ascending aorta (HP:0005111)2.90746081
39Abnormality of the phalanges of the 2nd finger (HP:0009541)2.89884404
40Vertebral compression fractures (HP:0002953)2.89362220
41Coronal craniosynostosis (HP:0004440)2.88424875
42Autoamputation (HP:0001218)2.86958196
43Stridor (HP:0010307)2.85096510
44Adrenal hypoplasia (HP:0000835)2.83584009
45Overgrowth (HP:0001548)2.81575866
46Spastic gait (HP:0002064)2.78328587
47Bowel diverticulosis (HP:0005222)2.76681240
48Intention tremor (HP:0002080)2.74680403
49Increased variability in muscle fiber diameter (HP:0003557)2.69484399
50Supranuclear gaze palsy (HP:0000605)2.68146282
51Osteolytic defects of the hand bones (HP:0009699)2.66559380
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.66559380
53Hyperextensible skin (HP:0000974)2.65933817
54Hypoventilation (HP:0002791)2.64311597
55Mitral regurgitation (HP:0001653)2.63946972
56Akinesia (HP:0002304)2.62580976
57Aplasia involving bones of the extremities (HP:0009825)2.60470874
58Aplasia involving bones of the upper limbs (HP:0009823)2.60470874
59Aplasia of the phalanges of the hand (HP:0009802)2.60470874
60Epiphyseal dysplasia (HP:0002656)2.59838247
61Mildly elevated creatine phosphokinase (HP:0008180)2.59493095
62Wide anterior fontanel (HP:0000260)2.57003303
63Blue sclerae (HP:0000592)2.53429906
64Joint laxity (HP:0001388)2.51104271
65Mild short stature (HP:0003502)2.49333348
66Bell-shaped thorax (HP:0001591)2.49167259
67Decreased lacrimation (HP:0000633)2.48632116
68Small epiphyses (HP:0010585)2.42279747
69Segmental peripheral demyelination/remyelination (HP:0003481)2.41969221
70Aortic regurgitation (HP:0001659)2.41765566
71Peritonitis (HP:0002586)2.41441625
72Infantile muscular hypotonia (HP:0008947)2.39642049
73Mitral valve prolapse (HP:0001634)2.39456563
74Congenital ichthyosiform erythroderma (HP:0007431)2.34622798
75Retinal dysplasia (HP:0007973)2.33811207
76Absent septum pellucidum (HP:0001331)2.33485636
77Dysmetria (HP:0001310)2.33477285
78Cerebral aneurysm (HP:0004944)2.30779219
79Anteriorly placed anus (HP:0001545)2.29342260
80Thickened helices (HP:0000391)2.28563092
81White forelock (HP:0002211)2.28109668
82Action tremor (HP:0002345)2.25094312
83Elbow flexion contracture (HP:0002987)2.23721913
84Patchy hypopigmentation of hair (HP:0011365)2.23462233
85Synostosis involving the elbow (HP:0003938)2.22925554
86Humeroradial synostosis (HP:0003041)2.22925554
87Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22055785
88Abnormality of the middle phalanges of the toes (HP:0010183)2.19705819
89Irregular epiphyses (HP:0010582)2.19483570
90Abnormality of skeletal muscle fiber size (HP:0012084)2.18869709
91Delayed epiphyseal ossification (HP:0002663)2.18368482
92Aneurysm (HP:0002617)2.17639681
93Turricephaly (HP:0000262)2.17017325
94Obstructive sleep apnea (HP:0002870)2.15272492
95Biconcave vertebral bodies (HP:0004586)2.14751698
96Abnormality of incisor morphology (HP:0011063)2.14088831
97Abnormality of glycolysis (HP:0004366)2.11957802
98Increased serum pyruvate (HP:0003542)2.11957802
99Foot dorsiflexor weakness (HP:0009027)2.11635634
100Hypoplasia of the iris (HP:0007676)2.10605733
101Muscle fiber splitting (HP:0003555)2.10063736
102Mitral stenosis (HP:0001718)2.09810670
103Ulnar bowing (HP:0003031)2.09770408
104Barrel-shaped chest (HP:0001552)2.09374762
105Spastic paraparesis (HP:0002313)2.06863448
106Leukodystrophy (HP:0002415)2.06119880
107Generalized amyotrophy (HP:0003700)2.04829862
108Hypoplastic ischia (HP:0003175)2.04823172
109Camptodactyly of toe (HP:0001836)2.04493024
110Abnormality of the ischium (HP:0003174)2.03973673
111Scanning speech (HP:0002168)2.03616012
112Myelomeningocele (HP:0002475)2.03014793
113Round ear (HP:0100830)2.02575619
114Abnormality of the fetal cardiovascular system (HP:0010948)2.02097704
115Abnormal umbilical cord blood vessels (HP:0011403)2.02097704
116Single umbilical artery (HP:0001195)2.02097704
117Slow saccadic eye movements (HP:0000514)2.01820441
118Abnormality of the septum pellucidum (HP:0007375)2.01703298
119Relative macrocephaly (HP:0004482)1.99875361
120Abnormality of dentin (HP:0010299)1.98119893
121Torticollis (HP:0000473)1.95770898
122Upper limb amyotrophy (HP:0009129)1.94013967
123Distal upper limb amyotrophy (HP:0007149)1.94013967
124Split foot (HP:0001839)1.93990189
125Abnormality of the 2nd finger (HP:0004100)1.91866760
126Mixed hearing impairment (HP:0000410)1.91301974
127Abnormal delivery (HP:0001787)1.91048983
128Esophageal atresia (HP:0002032)1.90787842
129Aortic valve stenosis (HP:0001650)1.88131134
130Limb-girdle muscle weakness (HP:0003325)1.88012539
131Clumsiness (HP:0002312)1.87618389
132Pheochromocytoma (HP:0002666)1.87001681
133Abnormality of the foot musculature (HP:0001436)1.86166515
134Spinal cord lesions (HP:0100561)1.85742797
135Syringomyelia (HP:0003396)1.85742797
136Wormian bones (HP:0002645)1.85104505
137Limited hip movement (HP:0008800)1.84596892
138Absent frontal sinuses (HP:0002688)1.84275696
139Prominent occiput (HP:0000269)1.84218746
140Increased connective tissue (HP:0009025)1.84017456
141Ankle clonus (HP:0011448)1.84006057
142Deviation of the hallux (HP:0010051)1.83996360
143Metaphyseal dysplasia (HP:0100255)1.83123917
144Protruding ear (HP:0000411)1.82939980
145Bradycardia (HP:0001662)1.82410159
146Broad metatarsal (HP:0001783)1.82245406
147Short nail (HP:0001799)1.80967609
148Lower limb muscle weakness (HP:0007340)1.80895640
149Cardiovascular calcification (HP:0011915)1.80298784
150Nasolacrimal duct obstruction (HP:0000579)1.80283470
151Gowers sign (HP:0003391)1.80255087
152Hallux valgus (HP:0001822)1.79987942
153Cupped ear (HP:0000378)1.78521687
154Abnormality of the acetabulum (HP:0003170)1.77971009
155Steppage gait (HP:0003376)1.76725729
156Achilles tendon contracture (HP:0001771)1.76415332
157Hypomagnesemia (HP:0002917)1.76103761
158Delayed cranial suture closure (HP:0000270)1.74578752
159Abnormality of the umbilical cord (HP:0010881)1.74561069
160Morphological abnormality of the inner ear (HP:0011390)1.74017618
161Long toe (HP:0010511)1.73666790
162Enlarged epiphyses (HP:0010580)1.73517327
163Hydroureter (HP:0000072)1.73018829
164Partial duplication of the phalanx of hand (HP:0009999)1.72654797
165Decreased motor nerve conduction velocity (HP:0003431)1.72583148
166Insomnia (HP:0100785)1.71892007
167Joint stiffness (HP:0001387)1.71230750
168Methylmalonic acidemia (HP:0002912)1.71214186
169Lower limb amyotrophy (HP:0007210)1.71111499
170Disproportionate tall stature (HP:0001519)1.70677486
171Chin dimple (HP:0010751)1.70456487
172Hypophosphatemic rickets (HP:0004912)1.70002647
173Ectopia lentis (HP:0001083)1.69583109
174Hepatosplenomegaly (HP:0001433)1.68881454
175Buphthalmos (HP:0000557)1.68832558
176Scapular winging (HP:0003691)1.67980646
177Partial agenesis of the corpus callosum (HP:0001338)1.67707722
178Megalencephaly (HP:0001355)1.67209790
179Renal duplication (HP:0000075)1.66948780
180Knee flexion contracture (HP:0006380)1.66902025
181Osteoarthritis (HP:0002758)1.65623187
182Spinal cord compression (HP:0002176)1.64483785
183Mesomelia (HP:0003027)1.64395200
184Thoracolumbar scoliosis (HP:0002944)1.64096796
185Congenital glaucoma (HP:0001087)1.62445677
186Flat cornea (HP:0007720)1.61282528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.30413157
2PRPF4B4.70312036
3OXSR14.33329994
4PDGFRA3.87118196
5MYLK3.61432620
6EPHB13.13743796
7BCR3.07122678
8PBK2.53370514
9MET2.51787088
10LATS22.40137067
11WNK42.40010375
12PKN12.32900520
13RIPK12.32505428
14PTK22.28650885
15FGFR22.27301107
16WNK12.16982295
17CDK192.09367741
18LIMK12.06385902
19NEK91.94143711
20TNIK1.90218594
21NEK61.89005333
22STK381.83549231
23TESK11.75771648
24MAPKAPK51.74639221
25CSNK1A1L1.73940214
26CSNK1G31.73116427
27TTN1.69219812
28AKT31.62128758
29ROCK21.61592683
30GRK51.59826268
31UHMK11.55784041
32PRKD21.55267882
33TGFBR21.51884441
34DDR21.51310767
35CASK1.48813229
36NTRK31.48668200
37CLK11.48361882
38ICK1.43325220
39CSNK1G11.41553241
40NTRK11.33245111
41GRK71.31003873
42CAMK2B1.22485600
43CSNK1G21.20773780
44SIK11.20720674
45SGK2231.16508168
46SGK4941.16508168
47PNCK1.16409728
48ERN11.16262974
49MST41.15068086
50CAMK2D1.14356076
51FGR1.12110026
52ABL21.11150863
53PAK61.10843659
54NTRK21.07373098
55PAK31.06012762
56TESK21.05605705
57CDC42BPA1.03830187
58TRPM71.02328175
59EPHA41.01915409
60DYRK21.01230274
61LMTK20.96924600
62MINK10.95245378
63JAK10.93843158
64PAK40.89453388
65PIK3CG0.89080405
66KSR20.88240396
67ADRBK10.87626567
68BMPR1B0.85260076
69CAMK2G0.83529756
70CDK140.82793282
71MUSK0.80283274
72TRIB30.79870104
73CAMKK10.78326814
74PRKG20.75863536
75DAPK30.75230969
76NUAK10.73838321
77PRKCQ0.72092353
78PRKCE0.70407963
79TYRO30.69737028
80CDK150.68990678
81RPS6KA20.68186321
82CAMKK20.67402139
83ERBB40.66851066
84MKNK10.66798446
85CAMK2A0.66715592
86CDK180.66489200
87ILK0.65035535
88MAPK150.64442603
89ARAF0.64370183
90CAMK10.64078102
91DAPK20.61953311
92PRKD10.61159395
93CDK50.60007290
94CDK11A0.59804031
95PRKCH0.59638378
96IRAK20.59404531
97SGK30.59001726
98MARK20.58445507
99ROCK10.54202343
100MAP3K120.52854477
101GSK3A0.52673591
102MAPK130.48322926
103RPS6KA50.48157294
104MTOR0.47880058
105PLK20.46615825
106MAP2K10.46260339
107CSNK1D0.45848727
108CSNK1A10.45507347
109PIK3CA0.45162537
110MAP3K90.44451757
111IRAK10.44065794
112MARK10.43725889
113FYN0.42913871
114PRKG10.42416790
115PHKG10.42326070
116PHKG20.42326070
117PAK10.41903834
118PDGFRB0.41301089
119MAP3K130.41299566
120SRC0.40902275
121SGK20.38945173
122KIT0.38227730
123BMX0.37588053
124PRKACB0.37384314
125PRKCG0.36906915
126PTK2B0.36897681
127TAOK20.36851077
128MAP3K60.36759480
129INSR0.34879965
130EPHB20.34859922
131LATS10.32724947
132EPHA30.32342606
133PDPK10.31456367
134PAK20.30823304
135MAPK70.29590508
136MAPK100.28705913
137YES10.27633383
138MKNK20.26848849
139BMPR20.26219981
140MOS0.24751226
141OBSCN0.24384926
142PRKD30.23665535
143PRKACA0.21996964
144DMPK0.21994638
145CSNK1E0.20343914
146CAMK1G0.20194151
147MAP2K20.19199265

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.51639641
2Steroid biosynthesis_Homo sapiens_hsa001005.08896646
3Fatty acid elongation_Homo sapiens_hsa000624.39085536
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.36760122
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.20890945
6Ether lipid metabolism_Homo sapiens_hsa005653.11983084
7Sphingolipid metabolism_Homo sapiens_hsa006002.25980110
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23781401
9Protein export_Homo sapiens_hsa030602.20428593
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.20212718
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.15147303
12Sulfur metabolism_Homo sapiens_hsa009202.13663645
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.11288708
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.06139881
15Axon guidance_Homo sapiens_hsa043602.06098202
16Vitamin B6 metabolism_Homo sapiens_hsa007501.73807864
17Synaptic vesicle cycle_Homo sapiens_hsa047211.68885280
18Long-term potentiation_Homo sapiens_hsa047201.63127518
19Proteoglycans in cancer_Homo sapiens_hsa052051.61900789
20Linoleic acid metabolism_Homo sapiens_hsa005911.59664830
21ECM-receptor interaction_Homo sapiens_hsa045121.53117366
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.50090006
23Insulin secretion_Homo sapiens_hsa049111.47974079
24Oxidative phosphorylation_Homo sapiens_hsa001901.46757890
25Gastric acid secretion_Homo sapiens_hsa049711.41533101
26Amoebiasis_Homo sapiens_hsa051461.40691269
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39392665
28Amphetamine addiction_Homo sapiens_hsa050311.33769214
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32563557
30Tight junction_Homo sapiens_hsa045301.32030007
31Arginine and proline metabolism_Homo sapiens_hsa003301.28622155
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27606982
33Histidine metabolism_Homo sapiens_hsa003401.27597856
34Glioma_Homo sapiens_hsa052141.25716534
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23963643
36Nicotine addiction_Homo sapiens_hsa050331.22892892
37Prion diseases_Homo sapiens_hsa050201.22751490
38Renin secretion_Homo sapiens_hsa049241.22609886
39* Gap junction_Homo sapiens_hsa045401.22545512
40Arachidonic acid metabolism_Homo sapiens_hsa005901.21933535
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21147680
42Renal cell carcinoma_Homo sapiens_hsa052111.16278281
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.15054740
44Adherens junction_Homo sapiens_hsa045201.15003522
45Estrogen signaling pathway_Homo sapiens_hsa049151.14521777
46Calcium signaling pathway_Homo sapiens_hsa040201.13932084
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12900090
48cAMP signaling pathway_Homo sapiens_hsa040241.11238713
49Melanoma_Homo sapiens_hsa052181.10504823
50* Rap1 signaling pathway_Homo sapiens_hsa040151.09913246
51GnRH signaling pathway_Homo sapiens_hsa049121.07756648
52Serotonergic synapse_Homo sapiens_hsa047261.07290597
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04780084
54Oxytocin signaling pathway_Homo sapiens_hsa049211.04727880
55Malaria_Homo sapiens_hsa051441.03675298
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02978908
57Hedgehog signaling pathway_Homo sapiens_hsa043401.02752102
58Alzheimers disease_Homo sapiens_hsa050101.01576323
59Glutathione metabolism_Homo sapiens_hsa004801.00221110
60Butanoate metabolism_Homo sapiens_hsa006500.99767347
61Parkinsons disease_Homo sapiens_hsa050120.97691506
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.97656766
63Vibrio cholerae infection_Homo sapiens_hsa051100.94551974
64Long-term depression_Homo sapiens_hsa047300.92803435
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92465402
66Thyroid hormone synthesis_Homo sapiens_hsa049180.91117653
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.88168914
68Ras signaling pathway_Homo sapiens_hsa040140.87611392
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87346189
70Mineral absorption_Homo sapiens_hsa049780.83719445
71Endocytosis_Homo sapiens_hsa041440.82716581
72Protein digestion and absorption_Homo sapiens_hsa049740.78049655
73Pancreatic secretion_Homo sapiens_hsa049720.76493497
74MicroRNAs in cancer_Homo sapiens_hsa052060.76098624
75Ovarian steroidogenesis_Homo sapiens_hsa049130.75850624
76Glutamatergic synapse_Homo sapiens_hsa047240.75706334
77Autoimmune thyroid disease_Homo sapiens_hsa053200.75407970
78Rheumatoid arthritis_Homo sapiens_hsa053230.74303181
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.73746902
80GABAergic synapse_Homo sapiens_hsa047270.73160771
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73066980
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73056298
83Hippo signaling pathway_Homo sapiens_hsa043900.70941691
84* Pathways in cancer_Homo sapiens_hsa052000.70624769
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70166060
86Basal cell carcinoma_Homo sapiens_hsa052170.69702872
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.68105387
88Phagosome_Homo sapiens_hsa041450.67318693
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66597529
90* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66497231
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66292839
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65935304
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.65654277
94Chronic myeloid leukemia_Homo sapiens_hsa052200.65169794
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64250656
96Lysosome_Homo sapiens_hsa041420.63616864
97Bile secretion_Homo sapiens_hsa049760.63147099
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62932974
99Small cell lung cancer_Homo sapiens_hsa052220.62881349
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62679889
101ErbB signaling pathway_Homo sapiens_hsa040120.62089057
102Fatty acid metabolism_Homo sapiens_hsa012120.61328847
103Bladder cancer_Homo sapiens_hsa052190.61181601
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.60781354
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59610144
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58705263
107Focal adhesion_Homo sapiens_hsa045100.57122702
108Cocaine addiction_Homo sapiens_hsa050300.56901962
109Inositol phosphate metabolism_Homo sapiens_hsa005620.55512120
110Wnt signaling pathway_Homo sapiens_hsa043100.55510406
111Morphine addiction_Homo sapiens_hsa050320.55171462
112TGF-beta signaling pathway_Homo sapiens_hsa043500.54763483
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54578327
114* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54355097
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52322660
116Cardiac muscle contraction_Homo sapiens_hsa042600.51606919
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.51552172
118Collecting duct acid secretion_Homo sapiens_hsa049660.50345453
119Circadian rhythm_Homo sapiens_hsa047100.49823364
120* Phospholipase D signaling pathway_Homo sapiens_hsa040720.49146500
121Endometrial cancer_Homo sapiens_hsa052130.48617128
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47422078
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47198108
124Folate biosynthesis_Homo sapiens_hsa007900.46997545
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46612101
126Phototransduction_Homo sapiens_hsa047440.45577844
127Huntingtons disease_Homo sapiens_hsa050160.45255739
128Dilated cardiomyopathy_Homo sapiens_hsa054140.45115604
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45030427
130Prostate cancer_Homo sapiens_hsa052150.44732980
131Fatty acid biosynthesis_Homo sapiens_hsa000610.44299992
132Asthma_Homo sapiens_hsa053100.43900385
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42850205
134Dorso-ventral axis formation_Homo sapiens_hsa043200.41888976
135Basal transcription factors_Homo sapiens_hsa030220.38347811
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37341321
137Metabolic pathways_Homo sapiens_hsa011000.35900620
138Circadian entrainment_Homo sapiens_hsa047130.35206655
139Vitamin digestion and absorption_Homo sapiens_hsa049770.35096254
140Melanogenesis_Homo sapiens_hsa049160.32299254
141Choline metabolism in cancer_Homo sapiens_hsa052310.32177479
142Propanoate metabolism_Homo sapiens_hsa006400.31931385
143Dopaminergic synapse_Homo sapiens_hsa047280.31930376
144Salivary secretion_Homo sapiens_hsa049700.31565767
145Cholinergic synapse_Homo sapiens_hsa047250.30042927
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29601132
147Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29595809
148Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28825967
149MAPK signaling pathway_Homo sapiens_hsa040100.28702588
150Salmonella infection_Homo sapiens_hsa051320.27006249
151Peroxisome_Homo sapiens_hsa041460.26705170

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