LPAR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)7.69033270
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.05698670
3epithelial cilium movement (GO:0003351)6.77134838
4hemidesmosome assembly (GO:0031581)6.50925521
5urinary tract smooth muscle contraction (GO:0014848)6.25707485
6bundle of His cell to Purkinje myocyte communication (GO:0086069)5.92006455
7lateral sprouting from an epithelium (GO:0060601)5.55186864
8regulation of posttranscriptional gene silencing (GO:0060147)5.42165725
9regulation of gene silencing by miRNA (GO:0060964)5.42165725
10regulation of gene silencing by RNA (GO:0060966)5.42165725
11adenosine metabolic process (GO:0046085)5.31827855
12behavioral response to pain (GO:0048266)4.96300005
13axoneme assembly (GO:0035082)4.91425488
14neuronal action potential (GO:0019228)4.89357286
15negative regulation of telomerase activity (GO:0051974)4.51947274
16regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.48407687
17keratinocyte proliferation (GO:0043616)4.48198990
18negative regulation of homotypic cell-cell adhesion (GO:0034111)4.47523108
19establishment of planar polarity (GO:0001736)4.45930951
20establishment of tissue polarity (GO:0007164)4.45930951
21establishment of apical/basal cell polarity (GO:0035089)4.33118926
22regulation of platelet aggregation (GO:0090330)3.90741603
23establishment or maintenance of monopolar cell polarity (GO:0061339)3.83421532
24establishment of monopolar cell polarity (GO:0061162)3.83421532
25response to xenobiotic stimulus (GO:0009410)3.73508922
26peristalsis (GO:0030432)3.72661835
27cardiac right ventricle morphogenesis (GO:0003215)3.63052625
28left/right pattern formation (GO:0060972)3.61016174
29negative regulation of T cell differentiation in thymus (GO:0033085)3.58631747
30male sex determination (GO:0030238)3.58515268
31negative regulation of keratinocyte proliferation (GO:0010839)3.56359958
32renal system development (GO:0072001)3.45335725
33positive regulation of synaptic transmission, GABAergic (GO:0032230)3.43858495
34cornea development in camera-type eye (GO:0061303)3.39427725
35response to pain (GO:0048265)3.37617007
36desmosome organization (GO:0002934)3.34216520
37negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.33721108
38regulation of hippo signaling (GO:0035330)3.30844078
39regulation of cilium movement (GO:0003352)3.29764711
40cell communication involved in cardiac conduction (GO:0086065)3.28605817
41regulation of keratinocyte proliferation (GO:0010837)3.24242561
42polarized epithelial cell differentiation (GO:0030859)3.23800531
43short-term memory (GO:0007614)3.21062751
44primary alcohol catabolic process (GO:0034310)3.20474089
45cilium organization (GO:0044782)3.20172741
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19545080
47anterior/posterior axis specification, embryo (GO:0008595)3.18760616
48membrane depolarization during action potential (GO:0086010)3.18576689
49detection of calcium ion (GO:0005513)3.15415759
50limb bud formation (GO:0060174)3.13878278
51negative regulation of dendrite morphogenesis (GO:0050774)3.13829539
52action potential (GO:0001508)3.12655156
53negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12599894
54negative regulation of complement activation (GO:0045916)3.10236418
55regulation of cardiac muscle contraction (GO:0055117)3.09256060
56positive regulation of cardiac muscle hypertrophy (GO:0010613)3.07567576
57positive regulation of muscle hypertrophy (GO:0014742)3.07567576
58membrane repolarization (GO:0086009)3.07440219
59negative regulation of protein localization to cell surface (GO:2000009)3.06999318
60gap junction assembly (GO:0016264)3.06886367
61regulation of striated muscle contraction (GO:0006942)3.05789125
62regulation of telomerase activity (GO:0051972)3.05573812
63peripheral nervous system neuron development (GO:0048935)3.05446584
64response to lipoprotein particle (GO:0055094)3.04602825
65regulation of cell communication by electrical coupling (GO:0010649)3.03365882
66establishment of skin barrier (GO:0061436)3.02144591
67white fat cell differentiation (GO:0050872)2.99746176
68cilium assembly (GO:0042384)2.99482888
69purinergic nucleotide receptor signaling pathway (GO:0035590)2.96645810
70membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.95564627
71left/right axis specification (GO:0070986)2.95235659
72branching involved in prostate gland morphogenesis (GO:0060442)2.93198784
73regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.93102642
74intestinal epithelial cell development (GO:0060576)2.91063116
75vitamin transmembrane transport (GO:0035461)2.90794001
76potassium ion export (GO:0071435)2.88230500
77cranial nerve morphogenesis (GO:0021602)2.87112022
78diterpenoid biosynthetic process (GO:0016102)2.86567722
79acrosome reaction (GO:0007340)2.86013353
80glomerular epithelial cell development (GO:0072310)2.85837260
81pyrimidine-containing compound transmembrane transport (GO:0072531)2.85145059
82microtubule bundle formation (GO:0001578)2.82665916
83positive regulation of fatty acid oxidation (GO:0046321)2.81910089
84regulation of mesoderm development (GO:2000380)2.81022187
85axonemal dynein complex assembly (GO:0070286)2.80129249
86positive regulation of potassium ion transmembrane transport (GO:1901381)2.80014778
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.79071164
88intraciliary transport (GO:0042073)2.78962358
89behavioral response to nicotine (GO:0035095)2.78866398
90ventricular system development (GO:0021591)2.78342852
91positive regulation of oligodendrocyte differentiation (GO:0048714)2.78255348
92regulation of water loss via skin (GO:0033561)2.78230578
93epithelial cell maturation (GO:0002070)2.78017307
94response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.77546338
95myoblast migration (GO:0051451)2.76677104
96response to nitrosative stress (GO:0051409)2.74675607
97membrane repolarization during action potential (GO:0086011)2.73850954
98keratinocyte development (GO:0003334)2.72898878
99lung-associated mesenchyme development (GO:0060484)2.72663501
100positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.72562425
101negative regulation of striated muscle cell apoptotic process (GO:0010664)2.72089964
102regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.71464914
103regulation of cardioblast differentiation (GO:0051890)2.71421895
104spindle assembly involved in mitosis (GO:0090307)2.69705576
105positive regulation of action potential (GO:0045760)2.69197205
106sex determination (GO:0007530)2.67229853
107negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.66788188
108prostate gland epithelium morphogenesis (GO:0060740)2.66679742
109hair cycle (GO:0042633)2.66551066
110molting cycle (GO:0042303)2.66551066
111response to ATP (GO:0033198)2.65579544
112regulation of homotypic cell-cell adhesion (GO:0034110)2.65348019
113positive regulation of cardiac muscle cell differentiation (GO:2000727)2.64427326
114positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.63156626
115regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.62968612
116regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.62612194
117negative regulation of gene silencing (GO:0060969)2.60926054
118branching involved in labyrinthine layer morphogenesis (GO:0060670)2.60842755
119neuromuscular synaptic transmission (GO:0007274)2.60619572
120cilium or flagellum-dependent cell motility (GO:0001539)2.59469696
121serine family amino acid catabolic process (GO:0009071)2.58555959
122glutathione derivative metabolic process (GO:1901685)2.58073613
123glutathione derivative biosynthetic process (GO:1901687)2.58073613
124epidermis development (GO:0008544)2.56974526
125negative regulation of cardiac muscle tissue development (GO:0055026)2.56338827
126regulation of sensory perception (GO:0051931)2.55951255
127regulation of sensory perception of pain (GO:0051930)2.55951255
128negative regulation of DNA biosynthetic process (GO:2000279)2.55572032
129motile cilium assembly (GO:0044458)2.55552360
130neuron remodeling (GO:0016322)2.55496124
131DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.54561523
132water-soluble vitamin biosynthetic process (GO:0042364)2.54230294
133intermediate filament organization (GO:0045109)2.52866269
134regulation of skeletal muscle contraction (GO:0014819)2.52787187
135neuron cell-cell adhesion (GO:0007158)2.52276944
136nucleoside diphosphate phosphorylation (GO:0006165)2.52237877
137negative regulation of systemic arterial blood pressure (GO:0003085)2.52138458
138positive regulation of cardiac muscle tissue development (GO:0055025)2.52047674
139keratinization (GO:0031424)2.51819684
140cardiac myofibril assembly (GO:0055003)2.51403561
141response to caffeine (GO:0031000)2.51320777
142phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.50461444
143enteric nervous system development (GO:0048484)2.49286687
144positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.48830948
145positive regulation of male gonad development (GO:2000020)2.48738985
146mesonephros development (GO:0001823)2.48236127
147regulation of actin filament-based movement (GO:1903115)2.48171835
148positive regulation of protein kinase C signaling (GO:0090037)2.47487597
149cerebral cortex radially oriented cell migration (GO:0021799)2.46127843
150ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.46015229
151regulation of the force of heart contraction (GO:0002026)2.45993592
152multicellular organismal water homeostasis (GO:0050891)2.45983626
153positive regulation of amino acid transport (GO:0051957)2.45840004
154mitochondrion morphogenesis (GO:0070584)2.45800651
155determination of left/right symmetry (GO:0007368)2.45595754
156negative regulation of skeletal muscle tissue development (GO:0048642)2.45152457
157polyol transport (GO:0015791)2.44703065
158reproductive system development (GO:0061458)2.44579000
159negative regulation of acute inflammatory response (GO:0002674)2.44270835
160male genitalia development (GO:0030539)2.43971911
161pseudouridine synthesis (GO:0001522)2.42540169
162mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.41831020
163mitochondrial respiratory chain complex I assembly (GO:0032981)2.41831020
164NADH dehydrogenase complex assembly (GO:0010257)2.41831020
165prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.41723282
166heart valve formation (GO:0003188)2.41205346
167regulation of mitotic spindle checkpoint (GO:1903504)2.40294928
168regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.40294928
169pharyngeal system development (GO:0060037)2.40102104
170UDP-N-acetylglucosamine metabolic process (GO:0006047)2.39564891
171DNA damage response, signal transduction resulting in transcription (GO:0042772)2.38552350
172regulation of tight junction assembly (GO:2000810)2.38389294
173cilium morphogenesis (GO:0060271)2.37796208
174regulation of male gonad development (GO:2000018)2.37477594
175retinoic acid metabolic process (GO:0042573)2.37140074
176negative regulation of cation channel activity (GO:2001258)2.36492979
177sensory perception of taste (GO:0050909)2.35922529
178organ formation (GO:0048645)2.35407235
179phasic smooth muscle contraction (GO:0014821)2.35161287
180cardiac muscle hypertrophy (GO:0003300)2.34179271
181positive regulation of cardiac muscle tissue growth (GO:0055023)2.33340091
182cellular response to prostaglandin stimulus (GO:0071379)2.33189425
183regulation of potassium ion transmembrane transport (GO:1901379)2.32623953
184cell communication by electrical coupling (GO:0010644)2.32288860
185glomerular basement membrane development (GO:0032836)2.31327013
186regulation of cardiac muscle hypertrophy (GO:0010611)2.30388401
187negative regulation of platelet activation (GO:0010544)2.30302410
188cardiac muscle tissue morphogenesis (GO:0055008)2.29468421
189atrioventricular valve morphogenesis (GO:0003181)2.29034788
190negative regulation of calcium ion transmembrane transport (GO:1903170)2.28389868
191negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.28389868
192membrane hyperpolarization (GO:0060081)2.27791430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.14256861
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.01339413
3EZH2_22144423_ChIP-Seq_EOC_Human3.73583219
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.12651355
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.63554864
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62552687
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61096400
8GBX2_23144817_ChIP-Seq_PC3_Human2.60731036
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60054069
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.53103711
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44702986
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.42441687
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40497864
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35613038
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31037745
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31037745
17VDR_22108803_ChIP-Seq_LS180_Human2.30413081
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28608093
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.25280842
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03710040
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01379222
22* EZH2_27294783_Chip-Seq_ESCs_Mouse1.98805857
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94502049
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.92716180
25FUS_26573619_Chip-Seq_HEK293_Human1.92411497
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89521898
27TAF15_26573619_Chip-Seq_HEK293_Human1.86352164
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.85689155
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.84848889
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82879002
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80602738
32* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80164807
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78172727
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.77056816
35* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.74194237
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74074048
37RNF2_27304074_Chip-Seq_NSC_Mouse1.71615303
38IGF1R_20145208_ChIP-Seq_DFB_Human1.67199926
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66574090
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66108947
41ZNF274_21170338_ChIP-Seq_K562_Hela1.65663995
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65559090
43AR_21572438_ChIP-Seq_LNCaP_Human1.63279997
44MYC_18940864_ChIP-ChIP_HL60_Human1.62345094
45FOXM1_26456572_ChIP-Seq_MCF-7_Human1.61701360
46SMAD4_21799915_ChIP-Seq_A2780_Human1.61343861
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59244151
48* TP63_23658742_ChIP-Seq_EP156T_Human1.56437064
49EWS_26573619_Chip-Seq_HEK293_Human1.55360360
50AR_21909140_ChIP-Seq_LNCAP_Human1.52586563
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.51471419
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51222677
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.50235714
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49245178
55P300_19829295_ChIP-Seq_ESCs_Human1.47376746
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.47149781
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.46270398
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46025377
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44737387
60* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.43448405
61FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.41579212
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38675830
63* PHF8_20622853_ChIP-Seq_HELA_Human1.38262199
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37162849
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.36725493
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36280066
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35878051
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35761506
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35504782
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34636530
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34454208
72* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.32340022
73* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31970765
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.31574414
75* ETV1_20927104_ChIP-Seq_GIST48_Human1.30466378
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.30276386
77* RBPJ_21746931_ChIP-Seq_IB4_Human1.29247187
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28845668
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.28099839
80NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.27277925
81TDRD3_21172665_ChIP-Seq_MCF-7_Human1.27155907
82* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26479071
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26470198
84AHR_22903824_ChIP-Seq_MCF-7_Human1.26462876
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26267053
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.25239402
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24307072
88* E2F1_18555785_Chip-Seq_ESCs_Mouse1.24151569
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.23050463
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22200266
91SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22200266
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22034437
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21428639
94* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20817970
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20803558
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.20458503
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19775025
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17433287
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16172981
100SMAD3_21741376_ChIP-Seq_HESCs_Human1.15898981
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15704082
102* HNFA_21074721_ChIP-Seq_CACO-2_Human1.15663939
103TP53_18474530_ChIP-ChIP_U2OS_Human1.15433234
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14924602
105* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13725612
106* P53_22387025_ChIP-Seq_ESCs_Mouse1.13351815
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.12913756
108RING1B_27294783_Chip-Seq_ESCs_Mouse1.10963974
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10613376
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10377118
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09992359
112* CMYC_18555785_Chip-Seq_ESCs_Mouse1.09540939
113FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.09525259
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09067569
115* GATA6_21074721_ChIP-Seq_CACO-2_Human1.09001356
116* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.08453671
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.08377144
118* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07900464
119SMAD4_21741376_ChIP-Seq_HESCs_Human1.07682366
120FOXO3_23340844_ChIP-Seq_DLD1_Human1.07590564
121STAT3_18555785_Chip-Seq_ESCs_Mouse1.07526330
122* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06953481
123* NFYB_21822215_ChIP-Seq_K562_Human1.06904299
124NFE2_27457419_Chip-Seq_LIVER_Mouse1.05974094
125* CDX2_22108803_ChIP-Seq_LS180_Human1.05391117
126EZH2_27294783_Chip-Seq_NPCs_Mouse1.05150379
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04734376
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04734376
129* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04547174
130FOXA1_25552417_ChIP-Seq_VCAP_Human1.04535115
131NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03947295
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03191700
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02959637
134ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02926648
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02813260
136KDM2B_26808549_Chip-Seq_REH_Human1.02405229
137* TBL1_22424771_ChIP-Seq_293T_Human1.02381475
138STAT3_23295773_ChIP-Seq_U87_Human1.02337053
139OCT4_18555785_Chip-Seq_ESCs_Mouse1.01973565
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01748247
141P300_18555785_Chip-Seq_ESCs_Mouse1.01712292
142SMAD4_21741376_ChIP-Seq_EPCs_Human1.01270212
143RING1B_27294783_Chip-Seq_NPCs_Mouse1.00858834
144EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00791968
145SOX2_18555785_Chip-Seq_ESCs_Mouse1.00101002
146* REST_21632747_ChIP-Seq_MESCs_Mouse0.99630952
147* NMYC_18555785_Chip-Seq_ESCs_Mouse0.99017303
148NOTCH1_21737748_ChIP-Seq_TLL_Human0.98072383
149RUNX2_22187159_ChIP-Seq_PCA_Human0.97369914
150BCAT_22108803_ChIP-Seq_LS180_Human0.97205898
151RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97056382
152TCF4_23295773_ChIP-Seq_U87_Human0.96758241
153GATA3_24758297_ChIP-Seq_MCF-7_Human0.96189420
154* NFYA_21822215_ChIP-Seq_K562_Human0.95111311
155TCF4_22108803_ChIP-Seq_LS180_Human0.94579130
156AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92747074
157KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91998833
158KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91998833
159KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91998833
160GATA4_25053715_ChIP-Seq_YYC3_Human0.90678703
161SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89497856
162MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88289579
163MYC_18555785_ChIP-Seq_MESCs_Mouse0.88057356
164SOX2_16153702_ChIP-ChIP_HESCs_Human0.87528188
165STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86896409
166* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86789642
167* FOXA1_25329375_ChIP-Seq_VCAP_Human0.86789642
168NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86628738
169AR_20517297_ChIP-Seq_VCAP_Human0.85550335
170* CHD1_26751641_Chip-Seq_LNCaP_Human0.84058213
171ELK1_19687146_ChIP-ChIP_HELA_Human0.83627837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after6.31056783
2MP0001968_abnormal_touch/_nociception6.04870185
3MP0002735_abnormal_chemical_nociception5.69132531
4MP0000579_abnormal_nail_morphology5.04037771
5MP0002102_abnormal_ear_morphology2.98986819
6MP0002733_abnormal_thermal_nociception2.95063855
7MP0000467_abnormal_esophagus_morphology2.79726893
8MP0002653_abnormal_ependyma_morphology2.74956013
9MP0009053_abnormal_anal_canal2.73889993
10MP0001986_abnormal_taste_sensitivity2.65078903
11MP0010234_abnormal_vibrissa_follicle2.55917257
12MP0003878_abnormal_ear_physiology2.51809325
13MP0005377_hearing/vestibular/ear_phenot2.51809325
14MP0002734_abnormal_mechanical_nocicepti2.45370522
15MP0001970_abnormal_pain_threshold2.44340051
16MP0000537_abnormal_urethra_morphology2.39173381
17MP0004084_abnormal_cardiac_muscle2.34887140
18MP0004185_abnormal_adipocyte_glucose2.31573741
19MP0005451_abnormal_body_composition2.28150851
20MP0005670_abnormal_white_adipose2.17911043
21MP0006276_abnormal_autonomic_nervous2.10636504
22MP0003937_abnormal_limbs/digits/tail_de2.08911265
23MP0002160_abnormal_reproductive_system2.04384721
24MP0000566_synostosis2.01216079
25MP0002796_impaired_skin_barrier2.00383036
26MP0004036_abnormal_muscle_relaxation1.91991028
27MP0000678_abnormal_parathyroid_gland1.91862366
28MP0003693_abnormal_embryo_hatching1.86324301
29MP0003941_abnormal_skin_development1.80870094
30MP0004145_abnormal_muscle_electrophysio1.79370745
31MP0004272_abnormal_basement_membrane1.78859026
32MP0008875_abnormal_xenobiotic_pharmacok1.78490145
33MP0004133_heterotaxia1.77837212
34MP0004742_abnormal_vestibular_system1.77645744
35MP0002282_abnormal_trachea_morphology1.73776580
36MP0002272_abnormal_nervous_system1.73333644
37MP0001849_ear_inflammation1.73207878
38MP0002277_abnormal_respiratory_mucosa1.72991681
39MP0001188_hyperpigmentation1.68828785
40MP0005623_abnormal_meninges_morphology1.67970663
41MP0008995_early_reproductive_senescence1.67418773
42MP0004215_abnormal_myocardial_fiber1.67006582
43MP0002067_abnormal_sensory_capabilities1.59467757
44MP0001216_abnormal_epidermal_layer1.57441320
45MP0003890_abnormal_embryonic-extraembry1.55448760
46MP0003119_abnormal_digestive_system1.55346550
47MP0002249_abnormal_larynx_morphology1.54764988
48MP0000013_abnormal_adipose_tissue1.53494998
49MP0008004_abnormal_stomach_pH1.53285280
50MP0004858_abnormal_nervous_system1.48965269
51MP0002254_reproductive_system_inflammat1.47334321
52MP0004019_abnormal_vitamin_homeostasis1.46649808
53MP0004043_abnormal_pH_regulation1.44826977
54MP0003950_abnormal_plasma_membrane1.43526871
55MP0003136_yellow_coat_color1.43355729
56MP0002060_abnormal_skin_morphology1.42804176
57MP0002972_abnormal_cardiac_muscle1.41591977
58MP0003137_abnormal_impulse_conducting1.38348779
59MP0008789_abnormal_olfactory_epithelium1.36137421
60MP0009384_cardiac_valve_regurgitation1.35582494
61MP0005389_reproductive_system_phenotype1.34222927
62MP0004885_abnormal_endolymph1.33109574
63MP0009379_abnormal_foot_pigmentation1.31030155
64MP0006292_abnormal_olfactory_placode1.30137293
65MP0004270_analgesia1.29882553
66MP0008877_abnormal_DNA_methylation1.26657292
67MP0003879_abnormal_hair_cell1.25349911
68MP0001293_anophthalmia1.24490271
69MP0000762_abnormal_tongue_morphology1.22803897
70MP0003718_maternal_effect1.22093518
71MP0000377_abnormal_hair_follicle1.21515395
72MP0001486_abnormal_startle_reflex1.19848581
73MP0000627_abnormal_mammary_gland1.19521321
74MP0002837_dystrophic_cardiac_calcinosis1.18706887
75MP0003880_abnormal_central_pattern1.18450231
76MP0004085_abnormal_heartbeat1.18261980
77MP0009046_muscle_twitch1.18156363
78MP0005171_absent_coat_pigmentation1.17533444
79MP0000383_abnormal_hair_follicle1.16781783
80MP0005410_abnormal_fertilization1.16597559
81MP0000749_muscle_degeneration1.16455305
82MP0003122_maternal_imprinting1.16391666
83MP0006138_congestive_heart_failure1.16095394
84MP0002111_abnormal_tail_morphology1.14949616
85MP0003567_abnormal_fetal_cardiomyocyte1.13755272
86MP0001661_extended_life_span1.13320625
87MP0004381_abnormal_hair_follicle1.10424343
88MP0005501_abnormal_skin_physiology1.10123140
89MP0008775_abnormal_heart_ventricle1.09178820
90MP0000751_myopathy1.08933172
91MP0003787_abnormal_imprinting1.08749786
92MP0003755_abnormal_palate_morphology1.07811688
93MP0003828_pulmonary_edema1.07114720
94MP0004957_abnormal_blastocyst_morpholog1.05982374
95MP0003453_abnormal_keratinocyte_physiol1.05950135
96MP0009780_abnormal_chondrocyte_physiolo1.05330321
97MP0002876_abnormal_thyroid_physiology1.05060115
98MP0000631_abnormal_neuroendocrine_gland1.03656973
99MP0009745_abnormal_behavioral_response1.02895401
100MP0003936_abnormal_reproductive_system1.02421889
101MP0005620_abnormal_muscle_contractility1.02262122
102MP0010030_abnormal_orbit_morphology1.01650354
103MP0010771_integument_phenotype1.01598964
104MP0006072_abnormal_retinal_apoptosis1.01081964
105MP0005646_abnormal_pituitary_gland1.00823497
106MP0001984_abnormal_olfaction1.00794851
107MP0003011_delayed_dark_adaptation0.99729985
108MP0001440_abnormal_grooming_behavior0.99188371
109MP0002697_abnormal_eye_size0.98057925
110MP0005330_cardiomyopathy0.94547405
111MP0000647_abnormal_sebaceous_gland0.93091388
112MP0004484_altered_response_of0.91961681
113MP0002184_abnormal_innervation0.91459263
114MP0000026_abnormal_inner_ear0.91240033
115MP0000681_abnormal_thyroid_gland0.88801718
116MP0005409_darkened_coat_color0.88567154
117MP0004147_increased_porphyrin_level0.86962159
118MP0009250_abnormal_appendicular_skeleto0.86431591
119MP0001963_abnormal_hearing_physiology0.86076653
120MP0004510_myositis0.85852352
121MP0000569_abnormal_digit_pigmentation0.85461287
122MP0003045_fibrosis0.85018244
123MP0000427_abnormal_hair_cycle0.84504187
124MP0005165_increased_susceptibility_to0.84321765
125MP0005595_abnormal_vascular_smooth0.83096212
126MP0005551_abnormal_eye_electrophysiolog0.82677052
127MP0008260_abnormal_autophagy0.81349766
128MP0002084_abnormal_developmental_patter0.81168307
129MP0001270_distended_abdomen0.80683817
130MP0000613_abnormal_salivary_gland0.80121194
131MP0001485_abnormal_pinna_reflex0.79440285
132MP0000049_abnormal_middle_ear0.79112268
133MP0001765_abnormal_ion_homeostasis0.78036099
134MP0003635_abnormal_synaptic_transmissio0.76777883
135MP0001286_abnormal_eye_development0.76328014
136MP0003938_abnormal_ear_development0.75459048
137MP0004264_abnormal_extraembryonic_tissu0.74592342
138MP0002064_seizures0.74300142
139MP0002127_abnormal_cardiovascular_syste0.73932440
140MP0000432_abnormal_head_morphology0.73108348
141MP0008932_abnormal_embryonic_tissue0.72881500
142MP0002751_abnormal_autonomic_nervous0.72400978
143MP0003566_abnormal_cell_adhesion0.72315195
144MP0003385_abnormal_body_wall0.72085590
145MP0001919_abnormal_reproductive_system0.71867649
146MP0002233_abnormal_nose_morphology0.71018722
147MP0004197_abnormal_fetal_growth/weight/0.69895864
148MP0001340_abnormal_eyelid_morphology0.69408108
149MP0000534_abnormal_ureter_morphology0.68853581
150MP0002234_abnormal_pharynx_morphology0.68640064
151MP0003942_abnormal_urinary_system0.68557066
152MP0002098_abnormal_vibrissa_morphology0.68352173
153MP0002572_abnormal_emotion/affect_behav0.67925837
154MP0002177_abnormal_outer_ear0.67525327
155MP0002085_abnormal_embryonic_tissue0.66649041
156MP0000516_abnormal_urinary_system0.66170916
157MP0005367_renal/urinary_system_phenotyp0.66170916
158MP0002752_abnormal_somatic_nervous0.66029631
159MP0002116_abnormal_craniofacial_bone0.65873268
160MP0001958_emphysema0.65542014
161MP0005253_abnormal_eye_physiology0.65230452
162MP0000778_abnormal_nervous_system0.64322221
163MP0001664_abnormal_digestion0.64145907
164MP0001544_abnormal_cardiovascular_syste0.63776232
165MP0005385_cardiovascular_system_phenoty0.63776232
166MP0010678_abnormal_skin_adnexa0.62541434
167MP0003315_abnormal_perineum_morphology0.62462704
168MP0005195_abnormal_posterior_eye0.61784143
169MP0010352_gastrointestinal_tract_polyps0.61485612

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.42393195
2Absent/shortened dynein arms (HP:0200106)4.42393195
3Bronchiectasis (HP:0002110)4.34839711
4Aplasia cutis congenita (HP:0001057)4.15660985
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.05863933
6Abnormal ciliary motility (HP:0012262)4.04734926
7Hypomagnesemia (HP:0002917)3.68810665
8Abnormal respiratory motile cilium physiology (HP:0012261)3.68458801
9Ulnar claw (HP:0001178)3.67190079
10Fragile nails (HP:0001808)3.60733730
11Pancreatic fibrosis (HP:0100732)3.56153031
12True hermaphroditism (HP:0010459)3.46787462
13Onycholysis (HP:0001806)3.40883945
14Upper limb muscle weakness (HP:0003484)3.36311500
15Pancreatic cysts (HP:0001737)3.29778489
16Abnormal respiratory epithelium morphology (HP:0012253)3.27392643
17Abnormal respiratory motile cilium morphology (HP:0005938)3.27392643
18Milia (HP:0001056)3.26921248
19Abnormality of nail color (HP:0100643)3.19712044
20Steppage gait (HP:0003376)3.13485771
21Plantar hyperkeratosis (HP:0007556)3.10130419
22Tubulointerstitial nephritis (HP:0001970)3.09631474
23Nasal polyposis (HP:0100582)3.02178062
24Atrial fibrillation (HP:0005110)2.98625160
25Double outlet right ventricle (HP:0001719)2.92932051
26Congenital malformation of the right heart (HP:0011723)2.92932051
27Thick nail (HP:0001805)2.91987688
28Abnormality of magnesium homeostasis (HP:0004921)2.90928706
29Morphological abnormality of the middle ear (HP:0008609)2.89511290
30Stenosis of the external auditory canal (HP:0000402)2.84887458
31Hypoplastic left heart (HP:0004383)2.83182764
32Sudden death (HP:0001699)2.83139826
33Short 1st metacarpal (HP:0010034)2.77236427
34Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.77236427
35Nephronophthisis (HP:0000090)2.74519434
36Syncope (HP:0001279)2.66585078
37Parakeratosis (HP:0001036)2.65902640
38Molar tooth sign on MRI (HP:0002419)2.65089750
39Abnormality of midbrain morphology (HP:0002418)2.65089750
40Preauricular pit (HP:0004467)2.63443640
41Periauricular skin pits (HP:0100277)2.63443640
42Primary atrial arrhythmia (HP:0001692)2.62910611
43Furrowed tongue (HP:0000221)2.60203429
44Abnormality of the lacrimal duct (HP:0011481)2.56525390
45White forelock (HP:0002211)2.53949039
46Occipital encephalocele (HP:0002085)2.53030079
47Hypoplasia of the iris (HP:0007676)2.52933243
48Cutaneous finger syndactyly (HP:0010554)2.51732211
49Popliteal pterygium (HP:0009756)2.46619600
50Maternal diabetes (HP:0009800)2.46070109
51Supraventricular arrhythmia (HP:0005115)2.45850218
52Supraventricular tachycardia (HP:0004755)2.45556020
53Abnormality of chloride homeostasis (HP:0011422)2.44654845
54Rhinitis (HP:0012384)2.44645747
55Chin dimple (HP:0010751)2.44508462
56Febrile seizures (HP:0002373)2.44135528
57Bradycardia (HP:0001662)2.41954854
58Focal motor seizures (HP:0011153)2.41312674
59Insidious onset (HP:0003587)2.40825222
60Termporal pattern (HP:0011008)2.40825222
61Short hallux (HP:0010109)2.40583737
62Cystic liver disease (HP:0006706)2.39144116
63Abnormality of the 1st metacarpal (HP:0010009)2.38399084
64Hypoplastic heart (HP:0001961)2.37108424
65Abnormality of the nasolacrimal system (HP:0000614)2.36267540
66Distal lower limb muscle weakness (HP:0009053)2.36128785
67Right ventricular cardiomyopathy (HP:0011663)2.35622717
68Abnormality of the parathyroid morphology (HP:0011766)2.33717935
69Esophageal atresia (HP:0002032)2.33255830
70Bronchitis (HP:0012387)2.32323412
71Patchy hypopigmentation of hair (HP:0011365)2.30805193
72Nasolacrimal duct obstruction (HP:0000579)2.29108229
73Septo-optic dysplasia (HP:0100842)2.26111374
74Palmoplantar hyperkeratosis (HP:0000972)2.25395413
75Hyporeflexia of lower limbs (HP:0002600)2.23883531
76Congenital sensorineural hearing impairment (HP:0008527)2.22447549
77Chronic hepatic failure (HP:0100626)2.21796242
78Chronic sinusitis (HP:0011109)2.21680053
79Asymmetry of the thorax (HP:0001555)2.21679084
80Abnormality of the renal collecting system (HP:0004742)2.19256411
81Carpal bone hypoplasia (HP:0001498)2.18527750
82Infertility (HP:0000789)2.18263501
83Conical tooth (HP:0000698)2.17960427
84Ventricular tachycardia (HP:0004756)2.17570111
85Submucous cleft hard palate (HP:0000176)2.17088419
86Palmar hyperkeratosis (HP:0010765)2.16467848
87Fused cervical vertebrae (HP:0002949)2.16349174
88Abnormality of the middle phalanges of the toes (HP:0010183)2.15380496
89Sex reversal (HP:0012245)2.15305116
90Abnormal sex determination (HP:0012244)2.15305116
91Lip pit (HP:0100267)2.15241792
92Abnormality of the renal medulla (HP:0100957)2.14974779
93Aplasia/Hypoplasia of the hallux (HP:0008362)2.14514693
94Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.14460327
95Hyperactive renin-angiotensin system (HP:0000841)2.14194512
96Sclerocornea (HP:0000647)2.13780560
97Metabolic alkalosis (HP:0200114)2.13523967
98Absent eyelashes (HP:0000561)2.13209476
99Abnormality of the ischium (HP:0003174)2.12269770
100Abnormality of the nasal mucosa (HP:0000433)2.12192099
101Hypoplastic labia majora (HP:0000059)2.10866092
102Chronic bronchitis (HP:0004469)2.09813706
103Anencephaly (HP:0002323)2.06964979
104Tubulointerstitial abnormality (HP:0001969)2.06612449
105Pendular nystagmus (HP:0012043)2.06153458
106Onion bulb formation (HP:0003383)2.06123606
107Oral leukoplakia (HP:0002745)2.05966861
108Hyperkalemia (HP:0002153)2.05628064
109Pulmonary artery stenosis (HP:0004415)2.02901524
110Aplasia of the phalanges of the hand (HP:0009802)2.02721350
111Aplasia involving bones of the extremities (HP:0009825)2.02721350
112Aplasia involving bones of the upper limbs (HP:0009823)2.02721350
113Short tibia (HP:0005736)2.02252413
114Male pseudohermaphroditism (HP:0000037)2.01550298
115Absent septum pellucidum (HP:0001331)2.00336782
116Hypoplasia of the uterus (HP:0000013)2.00049189
117Duplicated collecting system (HP:0000081)1.99491176
118Absent thumb (HP:0009777)1.98784735
119Ventricular fibrillation (HP:0001663)1.98562763
120Abnormality of the calf musculature (HP:0001430)1.98174034
121Segmental peripheral demyelination/remyelination (HP:0003481)1.98044683
122Metaphyseal dysplasia (HP:0100255)1.97749305
123Prolonged QT interval (HP:0001657)1.96988982
124Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.96182475
125Sparse eyelashes (HP:0000653)1.95336578
126Postaxial foot polydactyly (HP:0001830)1.93704481
127Abnormality of the labia majora (HP:0012881)1.93031555
128Ectopic kidney (HP:0000086)1.92999951
129Alopecia of scalp (HP:0002293)1.92908679
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.92838478
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.92742063
132Stage 5 chronic kidney disease (HP:0003774)1.92295991
133Abnormality of the nasal septum (HP:0000419)1.90800449
134Ventricular arrhythmia (HP:0004308)1.90419422
135Diaphragmatic weakness (HP:0009113)1.89795150
136Atonic seizures (HP:0010819)1.89469031
137Abnormality of renin-angiotensin system (HP:0000847)1.89267895
138Xerostomia (HP:0000217)1.87668191
139Dysautonomia (HP:0002459)1.87478479
140Cutaneous syndactyly (HP:0012725)1.87416641
141Focal seizures (HP:0007359)1.87405886
142Absent hair (HP:0002298)1.85827502
143Nasal speech (HP:0001611)1.85054977
144Abnormality of secondary sexual hair (HP:0009888)1.82672355
145Abnormality of the axillary hair (HP:0100134)1.82672355
146Congenital stationary night blindness (HP:0007642)1.81294827
147Oligodontia (HP:0000677)1.80544794
148Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80395523
149Degeneration of the lateral corticospinal tracts (HP:0002314)1.80395523
150Aplasia/hypoplasia of the uterus (HP:0008684)1.80214959
151Abnormality of the pulmonary veins (HP:0011718)1.78259272
152Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77900550
153Abnormality of incisor morphology (HP:0011063)1.77845853
154Tubular atrophy (HP:0000092)1.77802302
155Skin pits (HP:0100276)1.77507845
156Hypothermia (HP:0002045)1.77286777
157Abnormality of the musculature of the hand (HP:0001421)1.76968179
158Anophthalmia (HP:0000528)1.76620138
159Genital tract atresia (HP:0001827)1.76417136
160Pili torti (HP:0003777)1.76260448
161Epileptic encephalopathy (HP:0200134)1.74137458
162Recurrent sinusitis (HP:0011108)1.74134934
163Delayed epiphyseal ossification (HP:0002663)1.74121252
164Preaxial hand polydactyly (HP:0001177)1.72030835
165Woolly hair (HP:0002224)1.71497396
166Hypoplasia of dental enamel (HP:0006297)1.68547137
167Chorioretinal atrophy (HP:0000533)1.67646276
168Pterygium (HP:0001059)1.66398178
169Asplenia (HP:0001746)1.65798371
170Recurrent otitis media (HP:0000403)1.64741043
171Abnormality of the distal phalanges of the toes (HP:0010182)1.64476729
172Nail dystrophy (HP:0008404)1.64458108
173Short phalanx of the thumb (HP:0009660)1.62921947
174Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.61009969
175Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.60233999
176Wide intermamillary distance (HP:0006610)1.58237344
177Synostosis of carpal bones (HP:0005048)1.57147200
178Aplasia/Hypoplasia of the spleen (HP:0010451)1.56266160
179Congenital, generalized hypertrichosis (HP:0004540)1.56237406
180Congenital hepatic fibrosis (HP:0002612)1.55830201
181Amelogenesis imperfecta (HP:0000705)1.55680730
182Abnormality of the proximal phalanges of the hand (HP:0009834)1.54596454
183Labial hypoplasia (HP:0000066)1.52357098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.42436550
2RIPK43.45352409
3EPHA23.37673117
4STK243.18170754
5WNK43.01662213
6TAF13.00637105
7CASK2.67252446
8LATS12.59818562
9MAPKAPK32.49778108
10TNIK2.44639215
11STK392.43155079
12PRPF4B2.43136688
13GRK12.27519933
14AKT32.26073671
15PBK2.19696153
16LIMK12.18319281
17OBSCN2.08422996
18TTK2.07182517
19BMPR1B2.02539561
20MYLK1.94607528
21NTRK31.91125979
22NME11.90727335
23CAMK1D1.80664118
24STK38L1.78081220
25FRK1.71190827
26CDC71.68277029
27GRK51.66028854
28TSSK61.64659417
29STK31.61535803
30WNK11.60200549
31MAP2K71.59788290
32FER1.57272143
33PNCK1.57032207
34CAMK1G1.55347083
35OXSR11.53070808
36CDC42BPA1.48426718
37EEF2K1.41151152
38MET1.38080339
39BUB11.33018920
40CAMKK21.32421167
41MKNK21.31222773
42YES11.28347753
43PIK3CA1.26436828
44EPHA31.25206608
45TLK11.22973299
46BRSK21.21094122
47PRKCI1.20985257
48VRK21.20225415
49TGFBR11.18229330
50LMTK21.17679049
51MAP3K41.13300940
52CDK91.11359741
53BRAF1.10905296
54EPHB21.10613124
55WNK31.09762071
56MINK11.08570953
57MAP3K131.08543932
58MARK31.08240326
59PKN11.06124545
60DAPK21.06122057
61PINK10.98481280
62EPHB10.97699331
63MAPK150.97478671
64MAP3K120.96226074
65MAP2K40.95811298
66NEK60.95718748
67PRKCE0.92938934
68NUAK10.92824741
69MAPK130.91613532
70PAK60.90460313
71CHEK20.90158021
72ADRBK20.90110150
73MAP3K90.89882539
74MST1R0.89109770
75STK160.88735259
76FLT30.87371495
77BCR0.87132080
78ARAF0.86852199
79SMG10.86598079
80PLK10.83221377
81MAP3K140.82527530
82GRK70.80578756
83IRAK10.79974518
84ROCK10.79973558
85MUSK0.79029136
86CAMK10.76228059
87DMPK0.74790979
88LATS20.74002835
89MAP3K20.73103642
90PTK2B0.72431369
91ACVR1B0.72221380
92SIK30.71753759
93FGFR20.71567148
94ERBB40.71412075
95PAK30.71329548
96RET0.70905108
97ADRBK10.69633042
98AURKA0.69219196
99DYRK30.68801861
100BMPR20.68283895
101PTK20.68222601
102TESK10.66779484
103CAMK2A0.66586778
104SGK2230.66474853
105SGK4940.66474853
106MAP2K10.65514223
107ILK0.64354077
108EIF2AK20.62879934
109PRKD20.61575140
110EPHA40.61372749
111PDK40.60789792
112PDK30.60789792
113MKNK10.60433590
114TIE10.60000939
115TAOK20.59970725
116PRKACA0.59567776
117PLK30.56929633
118ZAK0.56606822
119ERBB30.55833062
120PIM20.54224586
121INSRR0.53941150
122WEE10.52909892
123ATR0.52445171
124PRKCH0.52286189
125ROCK20.51311659
126CSNK1E0.50609230
127MAP2K20.50545669
128KSR20.49822949
129NTRK10.49548102
130MST40.49548024
131MAPKAPK50.49421429
132RPS6KA50.48945331
133EIF2AK30.48313147
134FES0.47575605
135CAMK2D0.45978251
136SGK20.45960550
137PRKAA20.45845277
138FGFR10.44880404
139RPS6KB20.43777048
140PLK20.43603026
141FGR0.43317641
142UHMK10.42579525
143PDK20.41193610
144TRPM70.40763180
145DYRK20.39953135
146PRKG20.39893472
147CHEK10.39171272
148ERBB20.39120450
149SGK10.38866422
150PRKG10.38850568
151MATK0.38571077
152CSNK1G10.37768828
153PRKD30.37601403
154NLK0.34336529
155CSNK1A1L0.32150136
156CSNK1A10.31977830
157ATM0.30243944
158AURKB0.29660485
159ABL20.28936898

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.82931572
2Cardiac muscle contraction_Homo sapiens_hsa042602.79794098
3RNA polymerase_Homo sapiens_hsa030202.73705515
4Selenocompound metabolism_Homo sapiens_hsa004502.70060152
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.52994115
6Taste transduction_Homo sapiens_hsa047422.52677024
7Fatty acid elongation_Homo sapiens_hsa000622.31078705
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.30400742
9Histidine metabolism_Homo sapiens_hsa003402.29584582
10Sulfur metabolism_Homo sapiens_hsa009202.24337393
11Mineral absorption_Homo sapiens_hsa049782.15881179
12Chemical carcinogenesis_Homo sapiens_hsa052042.14861715
13Linoleic acid metabolism_Homo sapiens_hsa005912.09934989
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09685345
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04388492
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02785106
17Renin-angiotensin system_Homo sapiens_hsa046141.96078707
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87654204
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.86921335
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.86397729
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79535390
22Nicotine addiction_Homo sapiens_hsa050331.79065711
23Thyroid cancer_Homo sapiens_hsa052161.77791302
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77421405
25* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70246738
26Oxidative phosphorylation_Homo sapiens_hsa001901.68631760
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65757081
28Phenylalanine metabolism_Homo sapiens_hsa003601.62996525
29Axon guidance_Homo sapiens_hsa043601.61063853
30Salivary secretion_Homo sapiens_hsa049701.58545567
31Serotonergic synapse_Homo sapiens_hsa047261.56074118
32Basal transcription factors_Homo sapiens_hsa030221.54810211
33Calcium signaling pathway_Homo sapiens_hsa040201.54384796
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53630537
35Basal cell carcinoma_Homo sapiens_hsa052171.52991862
36Glutathione metabolism_Homo sapiens_hsa004801.51145256
37One carbon pool by folate_Homo sapiens_hsa006701.48538827
38Dilated cardiomyopathy_Homo sapiens_hsa054141.46577302
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.43995280
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43802132
41Protein digestion and absorption_Homo sapiens_hsa049741.43074177
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41304597
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39566788
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38526573
45Tyrosine metabolism_Homo sapiens_hsa003501.35043752
46Hippo signaling pathway_Homo sapiens_hsa043901.32915659
47Phototransduction_Homo sapiens_hsa047441.30992430
48Glutamatergic synapse_Homo sapiens_hsa047241.29690450
49Retinol metabolism_Homo sapiens_hsa008301.29328098
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.26944652
51Homologous recombination_Homo sapiens_hsa034401.25932035
52Oxytocin signaling pathway_Homo sapiens_hsa049211.25548745
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24917270
54Gastric acid secretion_Homo sapiens_hsa049711.24860007
55Collecting duct acid secretion_Homo sapiens_hsa049661.23897598
56ECM-receptor interaction_Homo sapiens_hsa045121.23343171
57Insulin secretion_Homo sapiens_hsa049111.21711128
58Ribosome_Homo sapiens_hsa030101.20711383
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.20096505
60Alzheimers disease_Homo sapiens_hsa050101.16427106
61Morphine addiction_Homo sapiens_hsa050321.15488367
62Renin secretion_Homo sapiens_hsa049241.15121442
63Parkinsons disease_Homo sapiens_hsa050121.15114205
64Pyrimidine metabolism_Homo sapiens_hsa002401.09687714
65RNA degradation_Homo sapiens_hsa030181.09461600
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05019282
67Tryptophan metabolism_Homo sapiens_hsa003801.03500135
68Nucleotide excision repair_Homo sapiens_hsa034201.01359898
69Purine metabolism_Homo sapiens_hsa002301.00541939
70Sphingolipid metabolism_Homo sapiens_hsa006000.99530007
71p53 signaling pathway_Homo sapiens_hsa041150.99290014
72Circadian entrainment_Homo sapiens_hsa047130.98194804
73Dorso-ventral axis formation_Homo sapiens_hsa043200.97467881
74Ether lipid metabolism_Homo sapiens_hsa005650.97235160
75Synaptic vesicle cycle_Homo sapiens_hsa047210.97085619
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95805176
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95472822
78Long-term depression_Homo sapiens_hsa047300.94833299
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93955029
80Huntingtons disease_Homo sapiens_hsa050160.92517729
81Amoebiasis_Homo sapiens_hsa051460.91650237
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90960500
83Fatty acid metabolism_Homo sapiens_hsa012120.88748500
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.88436487
85RNA transport_Homo sapiens_hsa030130.87499588
86Arginine and proline metabolism_Homo sapiens_hsa003300.86932811
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86663513
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86307445
89Butanoate metabolism_Homo sapiens_hsa006500.86152266
90Dopaminergic synapse_Homo sapiens_hsa047280.85951839
91Fanconi anemia pathway_Homo sapiens_hsa034600.82130011
92GABAergic synapse_Homo sapiens_hsa047270.81585971
93Melanoma_Homo sapiens_hsa052180.80954531
94Olfactory transduction_Homo sapiens_hsa047400.80510282
95Cholinergic synapse_Homo sapiens_hsa047250.80274519
96Spliceosome_Homo sapiens_hsa030400.80167870
97Tight junction_Homo sapiens_hsa045300.79553615
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79145724
99Pancreatic secretion_Homo sapiens_hsa049720.77892932
100GnRH signaling pathway_Homo sapiens_hsa049120.76677307
101cAMP signaling pathway_Homo sapiens_hsa040240.76026381
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75258738
103Vitamin digestion and absorption_Homo sapiens_hsa049770.74990300
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.74671220
105Protein export_Homo sapiens_hsa030600.74275393
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72562553
107Salmonella infection_Homo sapiens_hsa051320.72463010
108Arachidonic acid metabolism_Homo sapiens_hsa005900.70865935
109Phagosome_Homo sapiens_hsa041450.70796437
110Rheumatoid arthritis_Homo sapiens_hsa053230.70742307
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70291133
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69356404
113Choline metabolism in cancer_Homo sapiens_hsa052310.69331655
114Type II diabetes mellitus_Homo sapiens_hsa049300.68784024
115Metabolic pathways_Homo sapiens_hsa011000.68662921
116Glycerolipid metabolism_Homo sapiens_hsa005610.68469300
117Hedgehog signaling pathway_Homo sapiens_hsa043400.65136128
118Propanoate metabolism_Homo sapiens_hsa006400.64161866
119Ras signaling pathway_Homo sapiens_hsa040140.63308004
120Thyroid hormone synthesis_Homo sapiens_hsa049180.61848958
121Caffeine metabolism_Homo sapiens_hsa002320.61741390
122Steroid biosynthesis_Homo sapiens_hsa001000.61458260
123beta-Alanine metabolism_Homo sapiens_hsa004100.59901428
124Nitrogen metabolism_Homo sapiens_hsa009100.59320804
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59171286
126Wnt signaling pathway_Homo sapiens_hsa043100.59122616
127Focal adhesion_Homo sapiens_hsa045100.58050454
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57766203
129African trypanosomiasis_Homo sapiens_hsa051430.57597500
130Adherens junction_Homo sapiens_hsa045200.57474235
131Fatty acid biosynthesis_Homo sapiens_hsa000610.56033318
132Long-term potentiation_Homo sapiens_hsa047200.56010044
133* Rap1 signaling pathway_Homo sapiens_hsa040150.55773150
134Sulfur relay system_Homo sapiens_hsa041220.55624486
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53562057
136Pyruvate metabolism_Homo sapiens_hsa006200.52688207
137Circadian rhythm_Homo sapiens_hsa047100.52478129
138TGF-beta signaling pathway_Homo sapiens_hsa043500.51497961
139Non-homologous end-joining_Homo sapiens_hsa034500.51439010
140Melanogenesis_Homo sapiens_hsa049160.51410962
141Viral myocarditis_Homo sapiens_hsa054160.50907873
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50314033
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49523586
144Fatty acid degradation_Homo sapiens_hsa000710.49138876
145ErbB signaling pathway_Homo sapiens_hsa040120.47114881
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45873353
147Starch and sucrose metabolism_Homo sapiens_hsa005000.45781095
148Prostate cancer_Homo sapiens_hsa052150.45463867
149Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44382301
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.44090183
151Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42733678
152Ovarian steroidogenesis_Homo sapiens_hsa049130.41928679
153mRNA surveillance pathway_Homo sapiens_hsa030150.41302250
154Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40032655
155Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39920674
156MAPK signaling pathway_Homo sapiens_hsa040100.39163527
157* Pathways in cancer_Homo sapiens_hsa052000.39149584
158Inositol phosphate metabolism_Homo sapiens_hsa005620.39122432
159Toxoplasmosis_Homo sapiens_hsa051450.39070209
160Vitamin B6 metabolism_Homo sapiens_hsa007500.38781900
161Mismatch repair_Homo sapiens_hsa034300.38172215
162Fat digestion and absorption_Homo sapiens_hsa049750.37809872
163Small cell lung cancer_Homo sapiens_hsa052220.37673952
164Gap junction_Homo sapiens_hsa045400.37338915

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