LPAR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane repolarization during cardiac muscle cell action potential (GO:0086013)9.76321716
2membrane repolarization during action potential (GO:0086011)8.73333271
3membrane depolarization during cardiac muscle cell action potential (GO:0086012)8.06847586
4behavioral response to nicotine (GO:0035095)7.66253208
5regulation of skeletal muscle contraction (GO:0014819)7.36058610
6cellular response to exogenous dsRNA (GO:0071360)6.41051648
7cellular potassium ion homeostasis (GO:0030007)5.95828198
8membrane repolarization (GO:0086009)5.87578299
9magnesium ion transport (GO:0015693)5.78188112
10regulation of membrane repolarization (GO:0060306)5.54035845
11water-soluble vitamin biosynthetic process (GO:0042364)4.96956268
12regulation of DNA endoreduplication (GO:0032875)4.88944387
13paraxial mesoderm development (GO:0048339)4.85535102
14DNA deamination (GO:0045006)4.77484380
15kidney morphogenesis (GO:0060993)4.75168363
16notochord development (GO:0030903)4.55805416
17replicative senescence (GO:0090399)4.53113919
18lateral sprouting from an epithelium (GO:0060601)4.52774506
19DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.51056515
20positive regulation of histone deacetylation (GO:0031065)4.33863668
21parturition (GO:0007567)4.30299354
22vitamin catabolic process (GO:0009111)4.27195328
23fat-soluble vitamin catabolic process (GO:0042363)4.27195328
24lung-associated mesenchyme development (GO:0060484)4.27109845
25relaxation of cardiac muscle (GO:0055119)4.23391822
26regulation of non-canonical Wnt signaling pathway (GO:2000050)4.14479959
27positive regulation of potassium ion transmembrane transport (GO:1901381)4.10526926
28G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.06667801
29inner cell mass cell proliferation (GO:0001833)4.05002218
30radial glial cell differentiation (GO:0060019)4.04294879
31cardiovascular system development (GO:0072358)4.03042880
32chondrocyte proliferation (GO:0035988)4.02572749
33positive regulation of fatty acid beta-oxidation (GO:0032000)4.02165783
34negative regulation of protein localization to cell surface (GO:2000009)4.00450772
35negative regulation of T cell differentiation in thymus (GO:0033085)3.98379319
36limb bud formation (GO:0060174)3.97967539
37cellular response to electrical stimulus (GO:0071257)3.96715473
38mesenchymal-epithelial cell signaling (GO:0060638)3.93086806
39regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.92399289
40potassium ion import (GO:0010107)3.92304357
41response to xenobiotic stimulus (GO:0009410)3.91435849
42DNA damage response, signal transduction resulting in transcription (GO:0042772)3.90461194
43positive regulation of fatty acid oxidation (GO:0046321)3.89144713
44interferon-gamma secretion (GO:0072643)3.88724447
45epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.81502713
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.80893892
47NADH dehydrogenase complex assembly (GO:0010257)3.80893892
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.80893892
49spinal cord development (GO:0021510)3.78316459
50regulation of cell proliferation involved in kidney development (GO:1901722)3.77794239
51dermatan sulfate biosynthetic process (GO:0030208)3.76885434
52dermatan sulfate metabolic process (GO:0030205)3.75503623
53atrial cardiac muscle cell action potential (GO:0086014)3.73915806
54kinetochore organization (GO:0051383)3.68275997
55establishment of protein localization to mitochondrial membrane (GO:0090151)3.64779891
56regulation of heart rate by cardiac conduction (GO:0086091)3.59428878
57endothelium development (GO:0003158)3.59179675
58regulation of potassium ion transmembrane transport (GO:1901379)3.58191382
59cellular anion homeostasis (GO:0030002)3.57359183
60kinetochore assembly (GO:0051382)3.56583820
61negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.53204740
62outer ear morphogenesis (GO:0042473)3.51659031
63cellular response to dsRNA (GO:0071359)3.43380594
64segment specification (GO:0007379)3.42116547
65negative regulation of sodium ion transport (GO:0010766)3.40862624
66regulation of timing of cell differentiation (GO:0048505)3.40248670
67cell surface receptor signaling pathway involved in heart development (GO:0061311)3.39960095
68mesenchymal cell proliferation (GO:0010463)3.37143787
69positive regulation of endothelial cell differentiation (GO:0045603)3.33903432
70regulation of development, heterochronic (GO:0040034)3.33419476
71cell proliferation in forebrain (GO:0021846)3.31819038
72middle ear morphogenesis (GO:0042474)3.30675037
73mesenchyme morphogenesis (GO:0072132)3.30603817
74embryonic skeletal joint morphogenesis (GO:0060272)3.30138181
75positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.29546787
76glomerulus development (GO:0032835)3.29003049
77T cell lineage commitment (GO:0002360)3.27883612
78negative regulation of systemic arterial blood pressure (GO:0003085)3.27256984
79negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.27047465
80Notch signaling involved in heart development (GO:0061314)3.25867519
81positive regulation of synapse maturation (GO:0090129)3.24798481
82negative regulation of myoblast differentiation (GO:0045662)3.23972196
83regulation of histone deacetylation (GO:0031063)3.23602010
84regulation of tight junction assembly (GO:2000810)3.19675244
85one-carbon compound transport (GO:0019755)3.19403689
86lymph vessel development (GO:0001945)3.18636351
87positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.17980409
88positive regulation of astrocyte differentiation (GO:0048711)3.14604344
89phosphate ion homeostasis (GO:0055062)3.14082973
90trivalent inorganic anion homeostasis (GO:0072506)3.14082973
91neural crest cell development (GO:0014032)3.13533679
92regulation of endothelial cell differentiation (GO:0045601)3.12702810
93kidney mesenchyme development (GO:0072074)3.11322894
94mesonephros development (GO:0001823)3.11029396
95cell-cell signaling involved in cell fate commitment (GO:0045168)3.10944524
96positive regulation of protein deacetylation (GO:0090312)3.09222298
97otic vesicle formation (GO:0030916)3.09089887
98cardiac conduction (GO:0061337)3.07206488
99developmental induction (GO:0031128)3.05376170
100relaxation of muscle (GO:0090075)3.03311043
101negative regulation of oligodendrocyte differentiation (GO:0048715)3.01914172
102protein heterotrimerization (GO:0070208)3.00318072
103cell proliferation involved in kidney development (GO:0072111)3.00105927
104endocardial cushion morphogenesis (GO:0003203)2.99980970
105sulfation (GO:0051923)2.99719471
106heart trabecula morphogenesis (GO:0061384)2.99261053
107potassium ion homeostasis (GO:0055075)2.98737666
108sequestering of extracellular ligand from receptor (GO:0035581)2.98697306
109cardiac muscle cell action potential (GO:0086001)2.98680374
110organ induction (GO:0001759)2.98536350
111interkinetic nuclear migration (GO:0022027)2.98492143
112regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.98437867
113snRNA transcription (GO:0009301)2.97525251
114cell proliferation involved in metanephros development (GO:0072203)2.97001456
115regulation of mesenchymal cell apoptotic process (GO:2001053)2.96303792
116regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.96272814
117regulation of mesenchymal cell proliferation (GO:0010464)2.92648161
118negative regulation of response to food (GO:0032096)2.91250434
119negative regulation of appetite (GO:0032099)2.91250434
120negative regulation of DNA-templated transcription, elongation (GO:0032785)2.91183202
121convergent extension (GO:0060026)2.90470309
122retina vasculature morphogenesis in camera-type eye (GO:0061299)2.90365348
123regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.88781804
124negative regulation of telomere maintenance (GO:0032205)2.88682711
125negative regulation of astrocyte differentiation (GO:0048712)2.88157292
126protein complex biogenesis (GO:0070271)2.87136325
127heart valve formation (GO:0003188)2.86931177
128cardiac muscle cell action potential involved in contraction (GO:0086002)2.86582249
129response to electrical stimulus (GO:0051602)2.85510054
130embryonic forelimb morphogenesis (GO:0035115)2.85306300
131positive regulation of T cell apoptotic process (GO:0070234)2.84838757
132DNA replication checkpoint (GO:0000076)2.83329300
133negative regulation of axon extension involved in axon guidance (GO:0048843)2.83187091
134mesenchymal cell differentiation (GO:0048762)2.82838291
135pattern specification involved in kidney development (GO:0061004)2.82106379
136forelimb morphogenesis (GO:0035136)2.80065669
137negative regulation of glycogen biosynthetic process (GO:0045719)2.79819986
138blood vessel maturation (GO:0001955)2.79599815
139negative regulation of potassium ion transmembrane transport (GO:1901380)2.79059355
140branching involved in salivary gland morphogenesis (GO:0060445)2.78158852
141regulation of fatty acid beta-oxidation (GO:0031998)2.77990164
142endothelial cell differentiation (GO:0045446)2.77888785
143positive regulation of RNA splicing (GO:0033120)2.77580375
144mesenchymal cell development (GO:0014031)2.77468470
145ovulation cycle (GO:0042698)2.77270173
146metanephros development (GO:0001656)2.76143627
147regulation of mesoderm development (GO:2000380)2.74979281
148cardiac epithelial to mesenchymal transition (GO:0060317)2.74558798
149bone trabecula formation (GO:0060346)2.74247255
150protein localization to synapse (GO:0035418)2.73389418
151regulation of synapse maturation (GO:0090128)2.72633330
152proximal/distal pattern formation (GO:0009954)2.70745761
153positive regulation of extracellular matrix organization (GO:1903055)2.70475939
154positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.69507020
155positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.68959606
156mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.68686846
157positive regulation of cartilage development (GO:0061036)2.68609182
158mesenchymal cell differentiation involved in kidney development (GO:0072161)2.68574946
159mesenchymal cell differentiation involved in renal system development (GO:2001012)2.68574946
160positive regulation of cardiac muscle cell differentiation (GO:2000727)2.68401769
161regulation of hippo signaling (GO:0035330)2.67578572
162indolalkylamine metabolic process (GO:0006586)2.66139489
163hematopoietic stem cell proliferation (GO:0071425)2.66103451
164embryonic digestive tract morphogenesis (GO:0048557)2.66005040
165regulation of astrocyte differentiation (GO:0048710)2.65805131
166histone H2B ubiquitination (GO:0033523)2.65683155
167regulation of posttranscriptional gene silencing (GO:0060147)2.65156536
168regulation of gene silencing by miRNA (GO:0060964)2.65156536
169regulation of gene silencing by RNA (GO:0060966)2.65156536
170negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.64657769
171vitamin biosynthetic process (GO:0009110)2.64565034
172collagen fibril organization (GO:0030199)2.63395285
173positive regulation of mesenchymal cell proliferation (GO:0002053)2.63280500
174regulation of thymocyte apoptotic process (GO:0070243)2.63086979
175negative regulation of leukocyte chemotaxis (GO:0002689)2.62919954
176somite development (GO:0061053)2.62709530
177hippo signaling (GO:0035329)2.62486085
178somatic stem cell division (GO:0048103)2.61819392
179cochlea morphogenesis (GO:0090103)2.61128221
180epithelial to mesenchymal transition (GO:0001837)2.60622329
181gap junction assembly (GO:0016264)2.58941449
182metanephric mesenchyme development (GO:0072075)2.58744640
183alanine transport (GO:0032328)2.58282830
184negative regulation of chondrocyte differentiation (GO:0032331)2.58016302
185regulation of organ formation (GO:0003156)2.57492253
186regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.56829206
187energy homeostasis (GO:0097009)2.55963924
188extracellular negative regulation of signal transduction (GO:1900116)2.55649183
189extracellular regulation of signal transduction (GO:1900115)2.55649183
190mammary gland development (GO:0030879)2.53587705
191ventricular trabecula myocardium morphogenesis (GO:0003222)2.52698770
192branch elongation of an epithelium (GO:0060602)2.51971534
193glomerular basement membrane development (GO:0032836)2.50694727
194regulation of heart morphogenesis (GO:2000826)2.49754396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.56161019
2STAT6_21828071_ChIP-Seq_BEAS2B_Human5.04454440
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.94386741
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.89180415
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.50527775
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.24425316
7IRF1_19129219_ChIP-ChIP_H3396_Human3.00054379
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.81597700
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.79638770
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.79638770
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.79638770
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.74689580
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.64889734
14POU5F1_16153702_ChIP-ChIP_HESCs_Human2.60172634
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.58695645
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.47640746
17RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.39149171
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37758101
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.37669822
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.31610894
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.29768492
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.21887705
23FUS_26573619_Chip-Seq_HEK293_Human2.21338157
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.20647071
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.13150450
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13137470
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10863670
28* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.10075182
29BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03061392
30TP63_17297297_ChIP-ChIP_HaCaT_Human2.00557426
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92168535
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92168535
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91017090
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88906897
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88703507
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87816083
37TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.83282192
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77463951
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.77336109
40TP53_18474530_ChIP-ChIP_U2OS_Human1.71055413
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.70871147
42E2F7_22180533_ChIP-Seq_HELA_Human1.70085233
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.69070040
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67442358
45P300_19829295_ChIP-Seq_ESCs_Human1.66700036
46GBX2_23144817_ChIP-Seq_PC3_Human1.66058667
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64605562
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.59890022
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.59861683
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59734734
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.56912464
52ZNF274_21170338_ChIP-Seq_K562_Hela1.56757119
53TDRD3_21172665_ChIP-Seq_MCF-7_Human1.56508705
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56226373
55EWS_26573619_Chip-Seq_HEK293_Human1.54668182
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52286705
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52051980
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51596678
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51416187
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49615608
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49355984
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48382813
63REST_21632747_ChIP-Seq_MESCs_Mouse1.47476461
64IGF1R_20145208_ChIP-Seq_DFB_Human1.47159161
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.46831394
66VDR_22108803_ChIP-Seq_LS180_Human1.45778536
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41433045
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41375339
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40397054
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39284590
71CJUN_26792858_Chip-Seq_BT549_Human1.39002356
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37200903
73AHR_22903824_ChIP-Seq_MCF-7_Human1.34136261
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32260433
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.31766138
76RNF2_27304074_Chip-Seq_NSC_Mouse1.30306034
77* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28831929
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28281439
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28032922
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27954599
81FOXM1_23109430_ChIP-Seq_U2OS_Human1.27368204
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27119288
83AR_21572438_ChIP-Seq_LNCaP_Human1.25240736
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25225000
85TCF3_18692474_ChIP-Seq_MESCs_Mouse1.24111347
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.23868691
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21849785
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.20529395
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.19853895
90TP53_16413492_ChIP-PET_HCT116_Human1.19465266
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19306323
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19306323
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17390768
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15949262
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.15165334
96AR_25329375_ChIP-Seq_VCAP_Human1.14259788
97PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14196771
98FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14065305
99RXR_22108803_ChIP-Seq_LS180_Human1.13879982
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13564072
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13296703
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13296703
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12224364
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11783771
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.11769883
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11479862
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11190791
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.11100796
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.11019750
110* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11000401
111GATA3_21878914_ChIP-Seq_MCF-7_Human1.10661603
112SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10536943
113EP300_21415370_ChIP-Seq_HL-1_Mouse1.10429308
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10404209
115RING1B_27294783_Chip-Seq_ESCs_Mouse1.10071449
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09850075
117TAF15_26573619_Chip-Seq_HEK293_Human1.09326323
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.09070327
119MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08862484
120BRD4_25478319_ChIP-Seq_HGPS_Human1.08559127
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08508783
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08019385
123REST_18959480_ChIP-ChIP_MESCs_Mouse1.06722680
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06120936
125FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05756736
126NANOG_16153702_ChIP-ChIP_HESCs_Human1.05243512
127MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04089108
128ER_23166858_ChIP-Seq_MCF-7_Human1.04013577
129E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03600499
130CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02561379
131SOX2_16153702_ChIP-ChIP_HESCs_Human1.02508288
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02044564
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01707800
134MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01435631
135POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00703068
136RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99941804
137BCAT_22108803_ChIP-Seq_LS180_Human0.99361761
138SMAD4_21799915_ChIP-Seq_A2780_Human0.97317353
139MYC_18940864_ChIP-ChIP_HL60_Human0.97088966
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96359654
141CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96138193
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96009200
143NCOR_22424771_ChIP-Seq_293T_Human0.94997543
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93986030
145LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93559500
146STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.89541543
147ERG_21242973_ChIP-ChIP_JURKAT_Human0.89412698
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.88190315
149HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87533298
150TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87441519
151ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87436081
152SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87413084
153P68_20966046_ChIP-Seq_HELA_Human0.86580875
154GATA3_21867929_ChIP-Seq_TH1_Mouse0.85732534
155KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85256199
156E2F1_20622854_ChIP-Seq_HELA_Human0.84679793
157OCT1_27270436_Chip-Seq_PROSTATE_Human0.84412548
158CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83691128
159PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82521069
160SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82424012
161PHF8_20622854_ChIP-Seq_HELA_Human0.82043731
162SOX9_26525672_Chip-Seq_HEART_Mouse0.78896035
163AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78894684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.33329651
2MP0003136_yellow_coat_color4.44155145
3MP0000569_abnormal_digit_pigmentation3.47482240
4MP0005171_absent_coat_pigmentation3.20816357
5MP0005503_abnormal_tendon_morphology3.19757738
6MP0008438_abnormal_cutaneous_collagen3.19614175
7MP0003279_aneurysm3.17371084
8MP0002160_abnormal_reproductive_system3.11557623
9MP0004272_abnormal_basement_membrane2.97623901
10MP0010030_abnormal_orbit_morphology2.82752336
11MP0004130_abnormal_muscle_cell2.67761225
12MP0000049_abnormal_middle_ear2.61101275
13MP0003941_abnormal_skin_development2.57644202
14MP0001485_abnormal_pinna_reflex2.52639506
15MP0009250_abnormal_appendicular_skeleto2.44124288
16* MP0001879_abnormal_lymphatic_vessel2.43064647
17MP0010368_abnormal_lymphatic_system2.41283310
18MP0003890_abnormal_embryonic-extraembry2.29540554
19MP0009384_cardiac_valve_regurgitation2.21337278
20MP0008877_abnormal_DNA_methylation2.14666841
21MP0002938_white_spotting2.14648864
22MP0002653_abnormal_ependyma_morphology2.11445600
23MP0009379_abnormal_foot_pigmentation2.07436692
24MP0003718_maternal_effect2.06310737
25MP0005248_abnormal_Harderian_gland2.03038445
26* MP0003385_abnormal_body_wall2.00231320
27MP0003937_abnormal_limbs/digits/tail_de1.99041669
28MP0005389_reproductive_system_phenotype1.97110724
29MP0005508_abnormal_skeleton_morphology1.93038295
30MP0005623_abnormal_meninges_morphology1.92153314
31MP0004145_abnormal_muscle_electrophysio1.90431539
32MP0002249_abnormal_larynx_morphology1.87984400
33MP0000631_abnormal_neuroendocrine_gland1.87867107
34MP0003879_abnormal_hair_cell1.86325760
35MP0003693_abnormal_embryo_hatching1.81838219
36MP0003011_delayed_dark_adaptation1.79477202
37MP0009053_abnormal_anal_canal1.78699191
38MP0003942_abnormal_urinary_system1.78356488
39MP0005275_abnormal_skin_tensile1.76669470
40MP0002282_abnormal_trachea_morphology1.74575867
41MP0003755_abnormal_palate_morphology1.69278221
42MP0000566_synostosis1.67465452
43MP0003122_maternal_imprinting1.65250341
44MP0001958_emphysema1.59994798
45MP0003938_abnormal_ear_development1.58930379
46MP0008057_abnormal_DNA_replication1.57466431
47MP0008961_abnormal_basal_metabolism1.56391929
48MP0002177_abnormal_outer_ear1.55701994
49MP0001293_anophthalmia1.52298487
50MP0000428_abnormal_craniofacial_morphol1.49832730
51MP0002876_abnormal_thyroid_physiology1.48382729
52MP0003121_genomic_imprinting1.48151503
53MP0004885_abnormal_endolymph1.47248076
54MP0004215_abnormal_myocardial_fiber1.46522671
55MP0001440_abnormal_grooming_behavior1.45848576
56MP0000778_abnormal_nervous_system1.45457886
57MP0005646_abnormal_pituitary_gland1.40978973
58MP0000432_abnormal_head_morphology1.40716277
59MP0004134_abnormal_chest_morphology1.40577121
60MP0001873_stomach_inflammation1.36847823
61MP0004742_abnormal_vestibular_system1.36561157
62MP0003567_abnormal_fetal_cardiomyocyte1.34862100
63MP0006292_abnormal_olfactory_placode1.33694290
64* MP0002116_abnormal_craniofacial_bone1.32978843
65MP0003950_abnormal_plasma_membrane1.32931176
66MP0009697_abnormal_copulation1.31147849
67MP0002109_abnormal_limb_morphology1.30327697
68MP0003828_pulmonary_edema1.30208509
69MP0001299_abnormal_eye_distance/1.28346733
70MP0003935_abnormal_craniofacial_develop1.27997683
71MP0002837_dystrophic_cardiac_calcinosis1.26219582
72MP0002115_abnormal_skeleton_extremities1.25223548
73MP0000762_abnormal_tongue_morphology1.24305547
74MP0000537_abnormal_urethra_morphology1.23930218
75MP0002233_abnormal_nose_morphology1.23214474
76MP0004019_abnormal_vitamin_homeostasis1.22891788
77MP0002089_abnormal_postnatal_growth/wei1.22875150
78MP0002932_abnormal_joint_morphology1.21139799
79MP0000163_abnormal_cartilage_morphology1.20089454
80MP0002102_abnormal_ear_morphology1.18939805
81MP0004133_heterotaxia1.18685876
82MP0003123_paternal_imprinting1.17836398
83MP0003705_abnormal_hypodermis_morpholog1.16939914
84MP0002697_abnormal_eye_size1.15095704
85MP0005257_abnormal_intraocular_pressure1.12870703
86MP0004233_abnormal_muscle_weight1.12742117
87MP0003646_muscle_fatigue1.12259425
88MP0005174_abnormal_tail_pigmentation1.12144902
89MP0001765_abnormal_ion_homeostasis1.09956316
90MP0000372_irregular_coat_pigmentation1.09225336
91* MP0000767_abnormal_smooth_muscle1.08400172
92MP0001188_hyperpigmentation1.08307627
93MP0002095_abnormal_skin_pigmentation1.07838564
94MP0004142_abnormal_muscle_tone1.07272086
95MP0002638_abnormal_pupillary_reflex1.07211415
96MP0000470_abnormal_stomach_morphology1.06754156
97MP0001286_abnormal_eye_development1.05997192
98MP0000534_abnormal_ureter_morphology1.05566082
99MP0000015_abnormal_ear_pigmentation1.03232524
100MP0005367_renal/urinary_system_phenotyp1.02745873
101MP0000516_abnormal_urinary_system1.02745873
102MP0006054_spinal_hemorrhage1.01454867
103MP0001270_distended_abdomen1.00659839
104MP0001663_abnormal_digestive_system0.99989096
105MP0005423_abnormal_somatic_nervous0.99971470
106MP0002111_abnormal_tail_morphology0.99890259
107MP0002108_abnormal_muscle_morphology0.98880976
108MP0000427_abnormal_hair_cycle0.98603303
109MP0010386_abnormal_urinary_bladder0.97727764
110MP0002113_abnormal_skeleton_development0.96982061
111MP0000230_abnormal_systemic_arterial0.94991645
112MP0008058_abnormal_DNA_repair0.94756073
113MP0002163_abnormal_gland_morphology0.94137073
114MP0003119_abnormal_digestive_system0.93277181
115MP0005381_digestive/alimentary_phenotyp0.92321393
116MP0003315_abnormal_perineum_morphology0.92082298
117MP0003115_abnormal_respiratory_system0.92018376
118MP0004085_abnormal_heartbeat0.91827249
119MP0002272_abnormal_nervous_system0.90990218
120MP0005390_skeleton_phenotype0.90912845
121MP0005220_abnormal_exocrine_pancreas0.90677123
122MP0001853_heart_inflammation0.88399244
123MP0002127_abnormal_cardiovascular_syste0.88144913
124MP0006276_abnormal_autonomic_nervous0.87067073
125MP0000026_abnormal_inner_ear0.86653386
126MP0008007_abnormal_cellular_replicative0.86074435
127MP0001919_abnormal_reproductive_system0.85194971
128MP0003787_abnormal_imprinting0.85124437
129MP0001963_abnormal_hearing_physiology0.84937055
130MP0002751_abnormal_autonomic_nervous0.84352831
131MP0004185_abnormal_adipocyte_glucose0.84320645
132MP0002114_abnormal_axial_skeleton0.84086973
133MP0000383_abnormal_hair_follicle0.83842799
134* MP0004197_abnormal_fetal_growth/weight/0.82656889
135* MP0002128_abnormal_blood_circulation0.82296480
136MP0001968_abnormal_touch/_nociception0.80676879
137MP0005197_abnormal_uvea_morphology0.77758623
138MP0002152_abnormal_brain_morphology0.77024877
139MP0005551_abnormal_eye_electrophysiolog0.76308081
140MP0002063_abnormal_learning/memory/cond0.75735571
141MP0000955_abnormal_spinal_cord0.75167957
142* MP0002295_abnormal_pulmonary_circulatio0.74051973
143MP0005195_abnormal_posterior_eye0.73659550
144MP0003936_abnormal_reproductive_system0.73574500
145MP0003690_abnormal_glial_cell0.72824866
146MP0001944_abnormal_pancreas_morphology0.72805196
147MP0002736_abnormal_nociception_after0.72624427
148MP0002277_abnormal_respiratory_mucosa0.71492997
149MP0002925_abnormal_cardiovascular_devel0.71345147
150MP0001542_abnormal_bone_strength0.71288530
151MP0005084_abnormal_gallbladder_morpholo0.70603953
152MP0005448_abnormal_energy_balance0.70522415
153MP0004858_abnormal_nervous_system0.70475052
154MP0005167_abnormal_blood-brain_barrier0.69867685
155MP0002184_abnormal_innervation0.69794921
156MP0000733_abnormal_muscle_development0.68942678
157MP0000003_abnormal_adipose_tissue0.68898932
158MP0002064_seizures0.68529944
159* MP0001614_abnormal_blood_vessel0.68386213
160MP0001175_abnormal_lung_morphology0.67292619
161MP0002896_abnormal_bone_mineralization0.66867179
162MP0003137_abnormal_impulse_conducting0.66191723
163MP0001346_abnormal_lacrimal_gland0.65971999
164MP0005595_abnormal_vascular_smooth0.65849603
165MP0001340_abnormal_eyelid_morphology0.65305938
166MP0001915_intracranial_hemorrhage0.64371873

Predicted human phenotypes

RankGene SetZ-score
1Osteomalacia (HP:0002749)4.30775936
2Persistence of primary teeth (HP:0006335)4.18142876
3Clumsiness (HP:0002312)4.08883578
4Fibular hypoplasia (HP:0003038)4.02195947
5Short middle phalanx of the 5th finger (HP:0004220)3.88856414
6Oligodontia (HP:0000677)3.82511472
7Mesomelia (HP:0003027)3.75789088
8Decreased circulating renin level (HP:0003351)3.66849945
9Aplasia/Hypoplasia of the fibula (HP:0006492)3.53261156
10Aplasia involving bones of the extremities (HP:0009825)3.50681648
11Aplasia involving bones of the upper limbs (HP:0009823)3.50681648
12Aplasia of the phalanges of the hand (HP:0009802)3.50681648
13Paralysis (HP:0003470)3.39680468
14Short femoral neck (HP:0100864)3.37882244
15Supernumerary spleens (HP:0009799)3.35180772
16Protrusio acetabuli (HP:0003179)3.25291888
17Megalencephaly (HP:0001355)3.14791146
18Oral leukoplakia (HP:0002745)3.13853746
19Bilateral microphthalmos (HP:0007633)3.10483244
20Periauricular skin pits (HP:0100277)3.09346781
21Preauricular pit (HP:0004467)3.09346781
22Abnormality of the frontal sinuses (HP:0002687)3.06055423
23Morphological abnormality of the middle ear (HP:0008609)3.01717827
24Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.96563314
25Neonatal short-limb short stature (HP:0008921)2.94986187
26Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.90338109
27Aplasia/Hypoplasia of the patella (HP:0006498)2.86895519
28Abnormality of the phalanges of the 2nd finger (HP:0009541)2.84803276
29Bulbous nose (HP:0000414)2.81643929
30Abnormality of the phalanges of the 5th finger (HP:0004213)2.81544267
31Stenosis of the external auditory canal (HP:0000402)2.81221529
32Small hand (HP:0200055)2.75893255
33Anal stenosis (HP:0002025)2.75765685
34Hypoplasia of the ulna (HP:0003022)2.74308196
35Short 4th metacarpal (HP:0010044)2.71741043
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71741043
37Short hallux (HP:0010109)2.70583167
38Abnormality of the renal collecting system (HP:0004742)2.70148938
39Abnormality of DNA repair (HP:0003254)2.70113358
40Broad metatarsal (HP:0001783)2.70052161
41Partial agenesis of the corpus callosum (HP:0001338)2.67136920
42Asymmetry of the thorax (HP:0001555)2.66616542
43Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.64972246
44Premature rupture of membranes (HP:0001788)2.63724408
45Patellar aplasia (HP:0006443)2.61889999
46Hypoplastic left heart (HP:0004383)2.57064114
47Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.56826586
48Cutaneous syndactyly (HP:0012725)2.53620455
49Shallow orbits (HP:0000586)2.45813576
50Hypoplasia of dental enamel (HP:0006297)2.43323112
51Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.41150448
52Broad toe (HP:0001837)2.41051603
53Tubular atrophy (HP:0000092)2.40358065
54Absent thumb (HP:0009777)2.40111458
55Preaxial foot polydactyly (HP:0001841)2.38791078
56Skin pits (HP:0100276)2.37070711
57Short middle phalanx of finger (HP:0005819)2.34676999
58Concave nail (HP:0001598)2.34573515
59Aplasia/Hypoplasia of the hallux (HP:0008362)2.34102526
60Vascular calcification (HP:0004934)2.33601169
61Pancreatic cysts (HP:0001737)2.33417502
62Aortic dissection (HP:0002647)2.32173903
63Cutaneous finger syndactyly (HP:0010554)2.31415073
64Septo-optic dysplasia (HP:0100842)2.31308029
65Short 5th finger (HP:0009237)2.31260558
66Abnormality of the nasal septum (HP:0000419)2.30372831
67Broad long bones (HP:0005622)2.29194322
68Abnormality of the proximal phalanges of the hand (HP:0009834)2.27427371
69Slender long bone (HP:0003100)2.26897069
70Aplasia/Hypoplasia of the ulna (HP:0006495)2.25630472
71Aplasia/hypoplasia of the femur (HP:0005613)2.25100830
72Ectopic kidney (HP:0000086)2.23459295
73Follicular hyperkeratosis (HP:0007502)2.22096998
74Abnormality of the 4th metacarpal (HP:0010012)2.20468866
75Renal dysplasia (HP:0000110)2.20104230
76Coronal craniosynostosis (HP:0004440)2.19982126
77Methylmalonic acidemia (HP:0002912)2.17836214
78Spinal rigidity (HP:0003306)2.17370238
79Spinal cord lesions (HP:0100561)2.17181937
80Syringomyelia (HP:0003396)2.17181937
81Partial duplication of the phalanx of hand (HP:0009999)2.16402191
82Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.15275822
83Fused cervical vertebrae (HP:0002949)2.15154058
84Abnormality of the middle phalanges of the toes (HP:0010183)2.14411365
85Abnormality of the middle phalanges of the hand (HP:0009833)2.14000783
86Abnormality of the phalanges of the hallux (HP:0010057)2.13602544
87Abnormality of the fibula (HP:0002991)2.13037230
88Genetic anticipation (HP:0003743)2.12461375
89Congenital stationary night blindness (HP:0007642)2.12356817
90Hypoplastic heart (HP:0001961)2.11789954
91Neonatal hypoglycemia (HP:0001998)2.10482581
92Birth length less than 3rd percentile (HP:0003561)2.09844735
93Aplasia/Hypoplasia involving the musculature (HP:0001460)2.09298767
94Long nose (HP:0003189)2.08706945
95Abnormality of the nasolacrimal system (HP:0000614)2.08423360
96Lip pit (HP:0100267)2.08422288
97Embryonal renal neoplasm (HP:0011794)2.07993483
98Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06563466
99Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.06347502
100Skull defect (HP:0001362)2.05119554
101Abnormality of incisor morphology (HP:0011063)2.04850889
102Broad hallux (HP:0010055)2.03059923
103Nephroblastoma (Wilms tumor) (HP:0002667)2.02630181
104Hypoplasia of the radius (HP:0002984)2.02493424
105Methylmalonic aciduria (HP:0012120)2.01405354
106Facial shape deformation (HP:0011334)1.99925294
107Potter facies (HP:0002009)1.99925294
108Nephronophthisis (HP:0000090)1.99918124
109Bell-shaped thorax (HP:0001591)1.99690706
110Cardiovascular calcification (HP:0011915)1.98614111
111Broad ribs (HP:0000885)1.98456800
112Midline defect of the nose (HP:0004122)1.98163066
113Broad thumb (HP:0011304)1.97168614
114Broad phalanx (HP:0006009)1.95015990
115J-shaped sella turcica (HP:0002680)1.94652043
116Myelomeningocele (HP:0002475)1.94431287
117Abnormality of secondary sexual hair (HP:0009888)1.94045050
118Abnormality of the axillary hair (HP:0100134)1.94045050
119Abnormal number of incisors (HP:0011064)1.93354733
120Mixed hearing impairment (HP:0000410)1.93233184
121Pendular nystagmus (HP:0012043)1.92750732
122Duplicated collecting system (HP:0000081)1.92438586
123Increased number of teeth (HP:0011069)1.92428867
124White forelock (HP:0002211)1.92321562
125Aplasia cutis congenita (HP:0001057)1.91615044
126Abnormality of the lacrimal duct (HP:0011481)1.90842738
127Diastasis recti (HP:0001540)1.89894629
128Microglossia (HP:0000171)1.89817857
129Hypoplasia of the pons (HP:0012110)1.88783715
130Pulmonary artery stenosis (HP:0004415)1.88182150
131Metabolic alkalosis (HP:0200114)1.88171724
132Scapular winging (HP:0003691)1.88160077
133Enlarged kidneys (HP:0000105)1.87569439
134Maternal diabetes (HP:0009800)1.86189134
135Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.85788851
136Short 1st metacarpal (HP:0010034)1.85788851
137Partial duplication of thumb phalanx (HP:0009944)1.84586120
138Bony spicule pigmentary retinopathy (HP:0007737)1.83421449
139Broad finger (HP:0001500)1.83114208
140Progressive cerebellar ataxia (HP:0002073)1.82863282
141Aplasia/Hypoplasia of the sternum (HP:0006714)1.82828487
142Forearm undergrowth (HP:0009821)1.82290685
143Thoracic kyphosis (HP:0002942)1.81705070
144Rough bone trabeculation (HP:0100670)1.81625677
145Facial asymmetry (HP:0000324)1.80992884
146Aplasia/Hypoplasia of the tibia (HP:0005772)1.80353531
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79997610
148Adrenal hypoplasia (HP:0000835)1.79821964
149Chromsome breakage (HP:0040012)1.79429624
150Rib fusion (HP:0000902)1.79224859
151Abnormality of the 2nd finger (HP:0004100)1.79181726
152Congenital, generalized hypertrichosis (HP:0004540)1.78696128
153Fibular aplasia (HP:0002990)1.78616147
154Disproportionate short-trunk short stature (HP:0003521)1.78561559
155Hyperphosphatemia (HP:0002905)1.78220494
156Abnormality of abdominal situs (HP:0011620)1.78189035
157Abdominal situs inversus (HP:0003363)1.78189035
158Homocystinuria (HP:0002156)1.78041042
159Abnormality of homocysteine metabolism (HP:0010919)1.78041042
160Biconcave vertebral bodies (HP:0004586)1.77930546
161Wide intermamillary distance (HP:0006610)1.77747850
162Absent toe (HP:0010760)1.77161276
163Tarsal synostosis (HP:0008368)1.77099566
164Synostosis of carpal bones (HP:0005048)1.76938855
165Panhypogammaglobulinemia (HP:0003139)1.76117844
166Wide anterior fontanel (HP:0000260)1.75822130
167Vertebral fusion (HP:0002948)1.75184335
168Overgrowth (HP:0001548)1.75091522
169Absent hair (HP:0002298)1.74907376
170Hepatoblastoma (HP:0002884)1.73537990
171Radial bowing (HP:0002986)1.73285178
172Syncope (HP:0001279)1.73180013
173Broad phalanges of the hand (HP:0009768)1.72666120
174Abnormality of the shoulder girdle musculature (HP:0001435)1.72634972
175Decreased subcutaneous fat (HP:0001002)1.72603944
176Patchy hypopigmentation of hair (HP:0011365)1.72300301
177Bronchomalacia (HP:0002780)1.72061895
178Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71706329
179Abnormality of the pons (HP:0007361)1.71681844
180Molar tooth sign on MRI (HP:0002419)1.71601257
181Abnormality of midbrain morphology (HP:0002418)1.71601257
182Abnormality of dentin (HP:0010299)1.71163246
183Absent forearm bone (HP:0003953)1.70588869
184Aplasia involving forearm bones (HP:0009822)1.70588869
185Duplication of thumb phalanx (HP:0009942)1.69913567
186Bifid tongue (HP:0010297)1.69379176
187Soft skin (HP:0000977)1.69207023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK23.83078428
2CASK3.23206852
3EPHB23.23025461
4MKNK13.16916974
5SRPK12.95862943
6DDR22.83619497
7EPHA32.77078439
8TAF12.65469567
9PRKD32.57876615
10PBK2.48936031
11TIE12.27355549
12STK38L2.23539248
13ERBB32.17889515
14BLK2.17426120
15EIF2AK22.05650724
16YES11.99964010
17TGFBR11.99242598
18LATS11.94596832
19KDR1.91008428
20BMPR1B1.89262514
21PRKD21.85938502
22SGK4941.83153138
23SGK2231.83153138
24CDK81.74946388
25ZAK1.70645453
26SMG11.69988608
27MAP2K71.68679876
28CDC71.66646785
29MAP3K41.62997017
30LATS21.60797006
31ACVR1B1.60706610
32PNCK1.56994594
33BRSK21.54894518
34MAP2K41.53710375
35SGK31.42252932
36NLK1.42203682
37PLK21.41243467
38TNIK1.40644964
39WNK41.39737651
40BMX1.39432548
41VRK21.36573517
42STK31.34652823
43HIPK21.34226484
44CAMK1D1.33138812
45PHKG21.28781802
46PHKG11.28781802
47IRAK11.28083181
48STK161.27777527
49ADRBK21.27584838
50RPS6KA21.24373617
51PIK3CA1.19813047
52NEK21.18744945
53IRAK31.13418729
54TRIB31.13355074
55FER1.08304219
56STK111.08142264
57AKT31.07307429
58PLK31.05996612
59ERBB41.04865980
60EIF2AK30.99657930
61ICK0.99333129
62PLK40.99070389
63CAMKK20.98916235
64RPS6KA60.98604253
65MAPKAPK50.94835720
66TAOK30.93616793
67BCR0.92311145
68FGFR10.91545586
69PRKCE0.88591431
70DYRK30.87809501
71STK240.87545898
72PRKCG0.85417397
73CAMK1G0.85085232
74AURKA0.84335432
75CDK120.84201080
76NUAK10.83866648
77IRAK20.83730332
78GRK10.83409166
79MAP3K140.78252670
80PASK0.78066584
81VRK10.76908023
82PKN10.76844547
83DYRK20.76686772
84INSRR0.75561218
85RPS6KC10.75445822
86RPS6KL10.75445822
87TGFBR20.75134559
88ROCK10.74915781
89PLK10.74843497
90SIK20.72486696
91PTK60.72404815
92MAPK130.70332320
93WNK10.67369870
94FRK0.64535469
95WEE10.63859602
96CDK90.62704837
97PRKAA20.60835709
98SGK20.58888982
99AURKB0.58334247
100STK390.57870409
101FGFR30.57341820
102IGF1R0.57118513
103MAPK70.55286317
104MST40.55274361
105CDK70.55248500
106NTRK20.54523941
107CSNK1A1L0.54386165
108PRKAA10.52799521
109CLK10.51507738
110MELK0.48567044
111PIM10.47832865
112MAPK120.47195025
113BUB10.46348433
114TEC0.46201879
115AKT20.44979738
116PRKACA0.44130038
117CHUK0.43512738
118GSK3A0.43415717
119SGK10.43414521
120AKT10.43392396
121CSNK2A10.41665684
122CAMKK10.41406112
123PAK20.41385601
124INSR0.40758032
125ADRBK10.40745810
126TLK10.40255781
127BMPR20.40053963
128PAK30.39115434
129ERBB20.39110445
130OBSCN0.39029045
131RPS6KB20.38905760
132PTK2B0.38848403
133DMPK0.38739938
134PRKG20.38678118
135CHEK20.38653489
136GRK50.37846275
137PIK3CG0.36711397
138ATM0.36615505
139SRC0.35126372
140CDK60.35035857
141SIK10.35035338
142CDC42BPA0.34465475
143CDK10.34381668
144ATR0.33835967
145MAPK110.33507984
146NEK60.33445196
147DYRK1A0.33404274
148PDGFRA0.33274528
149RPS6KB10.32958688
150CSNK1A10.32957108
151EIF2AK10.32908960
152TTN0.32442776
153BCKDK0.31838579
154FGFR20.31494140
155CDK40.30634835
156MAPK140.30285814
157MARK20.29661568
158CAMK10.27054768
159NEK90.26809592
160MAPK80.26279220
161GRK70.24804727
162GSK3B0.24541449
163MAPKAPK30.24325598

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.83862298
2TGF-beta signaling pathway_Homo sapiens_hsa043502.66973820
3ECM-receptor interaction_Homo sapiens_hsa045122.62583097
4Nicotine addiction_Homo sapiens_hsa050332.37128876
5Fatty acid biosynthesis_Homo sapiens_hsa000612.32427817
6Nitrogen metabolism_Homo sapiens_hsa009102.29608321
7Malaria_Homo sapiens_hsa051442.29485459
8Cholinergic synapse_Homo sapiens_hsa047252.22900293
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.09554557
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.06350391
11Adherens junction_Homo sapiens_hsa045202.00548009
12Hippo signaling pathway_Homo sapiens_hsa043902.00295789
13Hedgehog signaling pathway_Homo sapiens_hsa043401.99438417
14Morphine addiction_Homo sapiens_hsa050321.97353002
15RNA polymerase_Homo sapiens_hsa030201.92472706
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85512638
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.84796278
18Melanoma_Homo sapiens_hsa052181.81782466
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.74672489
20Circadian entrainment_Homo sapiens_hsa047131.73688608
21Focal adhesion_Homo sapiens_hsa045101.72094133
22MicroRNAs in cancer_Homo sapiens_hsa052061.69834106
23Viral myocarditis_Homo sapiens_hsa054161.57054874
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56413220
25Glutamatergic synapse_Homo sapiens_hsa047241.55235672
26Sulfur relay system_Homo sapiens_hsa041221.55205442
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.54313445
28Protein digestion and absorption_Homo sapiens_hsa049741.51355237
29Cell cycle_Homo sapiens_hsa041101.50723586
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50435904
31Proteoglycans in cancer_Homo sapiens_hsa052051.47743166
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45036749
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.38011859
34Fanconi anemia pathway_Homo sapiens_hsa034601.36938915
35Renin secretion_Homo sapiens_hsa049241.36082098
36Serotonergic synapse_Homo sapiens_hsa047261.31161624
37Wnt signaling pathway_Homo sapiens_hsa043101.30269437
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28411764
39* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.26771387
40* Pathways in cancer_Homo sapiens_hsa052001.26477440
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.24754983
42Sulfur metabolism_Homo sapiens_hsa009201.24344625
43Phototransduction_Homo sapiens_hsa047441.24037534
44Selenocompound metabolism_Homo sapiens_hsa004501.24018133
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22483456
46African trypanosomiasis_Homo sapiens_hsa051431.21919692
47Oxytocin signaling pathway_Homo sapiens_hsa049211.21455344
48Small cell lung cancer_Homo sapiens_hsa052221.21307444
49Linoleic acid metabolism_Homo sapiens_hsa005911.21097226
50Spliceosome_Homo sapiens_hsa030401.18778546
51Prostate cancer_Homo sapiens_hsa052151.16579116
52p53 signaling pathway_Homo sapiens_hsa041151.15808584
53Cardiac muscle contraction_Homo sapiens_hsa042601.15615891
54Gastric acid secretion_Homo sapiens_hsa049711.14966172
55Dilated cardiomyopathy_Homo sapiens_hsa054141.14927436
56Melanogenesis_Homo sapiens_hsa049161.14581943
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13215530
58Vitamin digestion and absorption_Homo sapiens_hsa049771.12112972
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11932447
60Glycosaminoglycan degradation_Homo sapiens_hsa005311.11795163
61Arginine and proline metabolism_Homo sapiens_hsa003301.10506447
62GABAergic synapse_Homo sapiens_hsa047271.05239543
63* Rap1 signaling pathway_Homo sapiens_hsa040151.04605113
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03620810
65Ribosome_Homo sapiens_hsa030101.03242069
66Leukocyte transendothelial migration_Homo sapiens_hsa046701.03144306
67Dopaminergic synapse_Homo sapiens_hsa047281.02444272
68Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02020556
69Tryptophan metabolism_Homo sapiens_hsa003801.00757741
70Axon guidance_Homo sapiens_hsa043601.00714630
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00153974
72Arachidonic acid metabolism_Homo sapiens_hsa005900.96329351
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96031561
74Oxidative phosphorylation_Homo sapiens_hsa001900.95638715
75HTLV-I infection_Homo sapiens_hsa051660.92819651
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91463220
77Tight junction_Homo sapiens_hsa045300.91163127
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91075433
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90740007
80Dorso-ventral axis formation_Homo sapiens_hsa043200.89682978
81One carbon pool by folate_Homo sapiens_hsa006700.86917905
82Type II diabetes mellitus_Homo sapiens_hsa049300.86215198
83cAMP signaling pathway_Homo sapiens_hsa040240.83377303
84MAPK signaling pathway_Homo sapiens_hsa040100.82443601
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.81961886
86* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81264541
87Regulation of autophagy_Homo sapiens_hsa041400.80838538
88Graft-versus-host disease_Homo sapiens_hsa053320.80447920
89Autoimmune thyroid disease_Homo sapiens_hsa053200.79243972
90Colorectal cancer_Homo sapiens_hsa052100.79102044
91Glycerolipid metabolism_Homo sapiens_hsa005610.78957381
92Notch signaling pathway_Homo sapiens_hsa043300.77592288
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76844160
94Sphingolipid metabolism_Homo sapiens_hsa006000.76488145
95Homologous recombination_Homo sapiens_hsa034400.75782367
96Huntingtons disease_Homo sapiens_hsa050160.74859662
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74488522
98Parkinsons disease_Homo sapiens_hsa050120.70929116
99Amoebiasis_Homo sapiens_hsa051460.69344284
100Allograft rejection_Homo sapiens_hsa053300.69115429
101Chemical carcinogenesis_Homo sapiens_hsa052040.68716658
102RNA degradation_Homo sapiens_hsa030180.67907472
103Steroid biosynthesis_Homo sapiens_hsa001000.67646967
104Alzheimers disease_Homo sapiens_hsa050100.67221341
105Mineral absorption_Homo sapiens_hsa049780.65462063
106TNF signaling pathway_Homo sapiens_hsa046680.64962841
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64952923
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64702187
109Calcium signaling pathway_Homo sapiens_hsa040200.64521371
110Hematopoietic cell lineage_Homo sapiens_hsa046400.64204306
111Insulin secretion_Homo sapiens_hsa049110.62920529
112Systemic lupus erythematosus_Homo sapiens_hsa053220.61320218
113Insulin resistance_Homo sapiens_hsa049310.59342481
114Retinol metabolism_Homo sapiens_hsa008300.58107919
115Hepatitis B_Homo sapiens_hsa051610.57906847
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57768217
117Ras signaling pathway_Homo sapiens_hsa040140.57141675
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56866808
119mRNA surveillance pathway_Homo sapiens_hsa030150.56853456
120RNA transport_Homo sapiens_hsa030130.56527318
121PPAR signaling pathway_Homo sapiens_hsa033200.56407090
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52893207
123mTOR signaling pathway_Homo sapiens_hsa041500.52546306
124Renin-angiotensin system_Homo sapiens_hsa046140.51739806
125Pyrimidine metabolism_Homo sapiens_hsa002400.51141599
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50694319
127Cocaine addiction_Homo sapiens_hsa050300.50522532
128Asthma_Homo sapiens_hsa053100.49940086
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49633814
130Herpes simplex infection_Homo sapiens_hsa051680.49387069
131Alcoholism_Homo sapiens_hsa050340.49110132
132Pyruvate metabolism_Homo sapiens_hsa006200.48504559
133Leishmaniasis_Homo sapiens_hsa051400.46859539
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45840119
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45343511
136Lysine degradation_Homo sapiens_hsa003100.45166972
137beta-Alanine metabolism_Homo sapiens_hsa004100.45149675
138Mismatch repair_Homo sapiens_hsa034300.45099470
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44979808
140Long-term depression_Homo sapiens_hsa047300.43806447
141Taste transduction_Homo sapiens_hsa047420.43388753
142Ovarian steroidogenesis_Homo sapiens_hsa049130.43236825
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42591739
144Ether lipid metabolism_Homo sapiens_hsa005650.42558668
145Olfactory transduction_Homo sapiens_hsa047400.42526281
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42384085
147NF-kappa B signaling pathway_Homo sapiens_hsa040640.40190978
148FoxO signaling pathway_Homo sapiens_hsa040680.38527317
149Amphetamine addiction_Homo sapiens_hsa050310.37746620
150Caffeine metabolism_Homo sapiens_hsa002320.37565763
151Nucleotide excision repair_Homo sapiens_hsa034200.37183810
152Gap junction_Homo sapiens_hsa045400.36636684
153DNA replication_Homo sapiens_hsa030300.36380298
154Type I diabetes mellitus_Homo sapiens_hsa049400.35717215
155Intestinal immune network for IgA production_Homo sapiens_hsa046720.35667106
156Basal transcription factors_Homo sapiens_hsa030220.35382081
157Thyroid hormone synthesis_Homo sapiens_hsa049180.35294239
158Toxoplasmosis_Homo sapiens_hsa051450.34421082

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