LPAR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.91350887
2maintenance of protein location in nucleus (GO:0051457)6.79229645
3regulation of mammary gland epithelial cell proliferation (GO:0033599)6.19937910
4negative regulation of epidermis development (GO:0045683)6.13088211
5negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.12153080
6protein localization to kinetochore (GO:0034501)6.07027054
7somite rostral/caudal axis specification (GO:0032525)6.01447280
8regulation of response to osmotic stress (GO:0047484)5.92584555
9negative regulation of cell cycle G2/M phase transition (GO:1902750)5.69901010
10regulation of nuclear cell cycle DNA replication (GO:0033262)5.66206168
11muscle organ morphogenesis (GO:0048644)5.60320034
12neutrophil activation involved in immune response (GO:0002283)5.52355271
13regulation of telomere maintenance via telomerase (GO:0032210)5.46417237
14histone H4-K12 acetylation (GO:0043983)5.40496972
15histone H4-K8 acetylation (GO:0043982)5.40366764
16histone H4-K5 acetylation (GO:0043981)5.40366764
17rRNA transcription (GO:0009303)5.36542751
18negative regulation of telomerase activity (GO:0051974)5.32351115
19interferon-gamma production (GO:0032609)5.26481980
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.24143019
21regulation of MHC class I biosynthetic process (GO:0045343)5.18115058
22thrombin receptor signaling pathway (GO:0070493)5.05755933
23negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.03049730
24positive regulation of gamma-delta T cell activation (GO:0046645)5.01218265
25cytidine deamination (GO:0009972)4.91651260
26cytidine metabolic process (GO:0046087)4.91651260
27cytidine catabolic process (GO:0006216)4.91651260
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.89615841
29negative regulation of cell killing (GO:0031342)4.89615841
30negative regulation of epidermal cell differentiation (GO:0045605)4.80111965
31mitotic sister chromatid segregation (GO:0000070)4.70590251
32regulation of B cell receptor signaling pathway (GO:0050855)4.70568328
33heterochromatin organization (GO:0070828)4.64056118
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.61188764
35rRNA methylation (GO:0031167)4.60778046
36hormone catabolic process (GO:0042447)4.60566158
37protein localization to chromosome, centromeric region (GO:0071459)4.43457208
38nucleoside transmembrane transport (GO:1901642)4.33947372
39regulation of cilium movement (GO:0003352)4.32690407
40regulation of translation in response to stress (GO:0043555)4.30229357
41dendritic cell chemotaxis (GO:0002407)4.29260528
42phenol-containing compound catabolic process (GO:0019336)4.24086815
43rRNA modification (GO:0000154)4.23978971
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.21762311
45positive regulation of mast cell activation (GO:0033005)4.19818443
46negative regulation of telomere maintenance (GO:0032205)4.19628693
47positive regulation of DNA-dependent DNA replication (GO:2000105)4.18370572
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.17773628
49neutrophil activation (GO:0042119)4.14431972
50antigen processing and presentation of endogenous antigen (GO:0019883)4.12126091
51DNA replication-dependent nucleosome assembly (GO:0006335)4.10589606
52DNA replication-dependent nucleosome organization (GO:0034723)4.10589606
53histone H4-K16 acetylation (GO:0043984)4.08309838
54regulation of apoptotic process involved in morphogenesis (GO:1902337)4.07877199
55notochord development (GO:0030903)4.07326659
56chromatin assembly (GO:0031497)4.07014328
57modulation by symbiont of host immune response (GO:0052553)4.01310029
58positive regulation by symbiont of host defense response (GO:0052509)4.01310029
59modulation by symbiont of host defense response (GO:0052031)4.01310029
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.01310029
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.01310029
62positive regulation by organism of defense response of other organism involved in symbiotic interact4.01310029
63branching involved in mammary gland duct morphogenesis (GO:0060444)4.00095851
64primitive streak formation (GO:0090009)3.99854478
65B cell receptor signaling pathway (GO:0050853)3.99827657
66response to dietary excess (GO:0002021)3.98280710
67nuclear pore complex assembly (GO:0051292)3.95424897
68DNA replication checkpoint (GO:0000076)3.95365633
69positive regulation of protein deacetylation (GO:0090312)3.93887127
70regulation of myeloid leukocyte mediated immunity (GO:0002886)3.92489627
71adenosine receptor signaling pathway (GO:0001973)3.91348738
72sister chromatid segregation (GO:0000819)3.87645022
73G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.87419326
74immunoglobulin mediated immune response (GO:0016064)3.86562848
75quinone metabolic process (GO:1901661)3.85089436
76granulocyte activation (GO:0036230)3.82188167
77maintenance of protein localization in organelle (GO:0072595)3.81695207
78T cell migration (GO:0072678)3.81660543
79negative thymic T cell selection (GO:0045060)3.79876900
80tolerance induction (GO:0002507)3.75355273
81cyclooxygenase pathway (GO:0019371)3.71718093
82negative T cell selection (GO:0043383)3.67440790
83coenzyme catabolic process (GO:0009109)3.66545635
84regulation of alpha-beta T cell proliferation (GO:0046640)3.66158213
85intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.66149139
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66029582
87positive regulation of B cell differentiation (GO:0045579)3.63609624
88dendritic cell migration (GO:0036336)3.63605684
89regulation of platelet aggregation (GO:0090330)3.63385256
90macrophage activation involved in immune response (GO:0002281)3.59755974
91regulation of mast cell degranulation (GO:0043304)3.58782448
92regulation of leukocyte degranulation (GO:0043300)3.57397315
93positive regulation of alpha-beta T cell proliferation (GO:0046641)3.56990635
94intestinal epithelial cell development (GO:0060576)3.56472315
95retinoic acid receptor signaling pathway (GO:0048384)3.52048500
96positive regulation of granulocyte differentiation (GO:0030854)3.51997340
97vitamin A metabolic process (GO:0006776)3.51484040
98regulation of gamma-delta T cell activation (GO:0046643)3.50932389
99mRNA stabilization (GO:0048255)3.48050889
100RNA stabilization (GO:0043489)3.48050889
101positive regulation of histone deacetylation (GO:0031065)3.46272937
102detection of bacterium (GO:0016045)3.44071504
103B cell mediated immunity (GO:0019724)3.43505590
104cell fate commitment involved in formation of primary germ layer (GO:0060795)3.42923847
105GDP-mannose metabolic process (GO:0019673)3.40819720
106maternal placenta development (GO:0001893)3.40730156
107myeloid cell activation involved in immune response (GO:0002275)3.40685650
108detection of other organism (GO:0098543)3.39854371
109cellular modified amino acid catabolic process (GO:0042219)3.39272759
110pyrimidine ribonucleoside catabolic process (GO:0046133)3.38305642
111nuclear pore organization (GO:0006999)3.38016280
112lipoxygenase pathway (GO:0019372)3.37702232
113trophectodermal cell differentiation (GO:0001829)3.36944195
114megakaryocyte development (GO:0035855)3.36901824
115positive regulation of mast cell activation involved in immune response (GO:0033008)3.36345745
116positive regulation of mast cell degranulation (GO:0043306)3.36345745
117G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.34952726
118purinergic nucleotide receptor signaling pathway (GO:0035590)3.34457810
119negative regulation of interleukin-2 production (GO:0032703)3.34280226
120positive thymic T cell selection (GO:0045059)3.33354586
121response to interleukin-15 (GO:0070672)3.31768415
122regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.31762941
123regulation of mast cell activation involved in immune response (GO:0033006)3.30615513
124mitochondrion distribution (GO:0048311)3.30579033
125tachykinin receptor signaling pathway (GO:0007217)3.29296077
126germinal center formation (GO:0002467)3.28016867
127ribosome biogenesis (GO:0042254)3.27381097
128regulation of mast cell activation (GO:0033003)3.27303436
129regulation of gamma-delta T cell differentiation (GO:0045586)3.26930229
130positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.26747545
131regulation of telomere maintenance (GO:0032204)3.26715080
132negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.25160726
133positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.24335687
134epoxygenase P450 pathway (GO:0019373)3.21623225
135pre-miRNA processing (GO:0031054)3.21304903
136regulation of telomerase activity (GO:0051972)3.21268056
137nucleoside transport (GO:0015858)3.21172119
138intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.20648544
139thymic T cell selection (GO:0045061)3.20404488
140formation of translation preinitiation complex (GO:0001731)3.19881349
141microglial cell activation (GO:0001774)3.18558518
142apoptotic DNA fragmentation (GO:0006309)3.17831513
143positive regulation of macrophage differentiation (GO:0045651)3.17760883
144negative regulation of erythrocyte differentiation (GO:0045647)3.17603987
145negative regulation of leukocyte mediated immunity (GO:0002704)3.17388366
146cellular response to interleukin-15 (GO:0071350)3.17043436
147regulation of B cell differentiation (GO:0045577)3.16209168
148icosanoid secretion (GO:0032309)3.15638034
149arachidonic acid secretion (GO:0050482)3.15638034
150transcription from mitochondrial promoter (GO:0006390)3.13716575
151T cell selection (GO:0045058)3.13526234
152purinergic receptor signaling pathway (GO:0035587)3.12720456
153DNA duplex unwinding (GO:0032508)3.11438042
154regulation of antigen processing and presentation (GO:0002577)3.09701408
155pore complex assembly (GO:0046931)3.09014437
156pseudouridine synthesis (GO:0001522)3.08863944
157positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07484061
158DNA geometric change (GO:0032392)3.06512523
159DNA damage response, detection of DNA damage (GO:0042769)3.06092849
160positive regulation of B cell mediated immunity (GO:0002714)3.02565088
161positive regulation of immunoglobulin mediated immune response (GO:0002891)3.02565088
162cullin deneddylation (GO:0010388)3.02002346
163leukocyte degranulation (GO:0043299)3.01839946
164negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.00832477
165cardiovascular system development (GO:0072358)3.00504242
166positive regulation of defense response to virus by host (GO:0002230)2.97763033
167regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.96884972
168antigen receptor-mediated signaling pathway (GO:0050851)2.96693461
169negative regulation of phagocytosis (GO:0050765)2.96587499
170angiogenesis involved in wound healing (GO:0060055)2.95953393
171cofactor transport (GO:0051181)2.95457706
172negative regulation of type 2 immune response (GO:0002829)2.94961903
173hypotonic response (GO:0006971)2.93195686
174positive T cell selection (GO:0043368)2.91884319
175establishment of endothelial barrier (GO:0061028)2.91558109
176regulation of platelet activation (GO:0010543)2.90931955
177transepithelial transport (GO:0070633)2.90569264
178leukocyte migration involved in inflammatory response (GO:0002523)2.89946639
179leukocyte aggregation (GO:0070486)2.89528682
180regulation of hypersensitivity (GO:0002883)2.89527427
181negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.89118708
182negative regulation of T-helper cell differentiation (GO:0045623)2.89118708
183regulation of interferon-beta biosynthetic process (GO:0045357)2.87437858
184negative regulation of bone resorption (GO:0045779)2.86786336
185positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.86286003
186negative regulation of lymphocyte mediated immunity (GO:0002707)2.86064939
187negative regulation of interleukin-12 production (GO:0032695)2.85519776
188regulation of regulated secretory pathway (GO:1903305)2.84843484
189positive regulation of monocyte chemotaxis (GO:0090026)2.82422290
190T cell costimulation (GO:0031295)2.81389974
191mast cell activation (GO:0045576)2.80146998
192negative regulation of T cell mediated immunity (GO:0002710)2.79323997
193lymphocyte chemotaxis (GO:0048247)2.78723080
194regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77522357
195regulation of natural killer cell mediated immunity (GO:0002715)2.77329280
196regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.77329280
197lymphocyte costimulation (GO:0031294)2.76747351
198polyketide metabolic process (GO:0030638)10.7784032
199doxorubicin metabolic process (GO:0044598)10.7784032
200daunorubicin metabolic process (GO:0044597)10.7784032

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.80480207
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.70309339
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.70309339
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.70309339
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.66067505
6E2F7_22180533_ChIP-Seq_HELA_Human4.62704160
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.18627770
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.15156723
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.90543268
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.63592534
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.42342689
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.92933240
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.84740285
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.83972128
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75944732
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.75604489
17RUNX_20019798_ChIP-Seq_JUKART_Human2.68729342
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.65704291
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58444412
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.57467536
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.53112099
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50820735
23GATA1_22025678_ChIP-Seq_K562_Human2.49857066
24SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.42524014
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41681318
26* MYB_26560356_Chip-Seq_TH2_Human2.36729191
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32523655
28* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.29856005
29STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29808297
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.29580050
31E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26674202
32* UTX_26944678_Chip-Seq_JUKART_Human2.17246991
33TCF3_18692474_ChIP-Seq_MEFs_Mouse2.17040029
34TCF3_18692474_ChIP-Seq_MESCs_Mouse2.16197609
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15849426
36GATA1_19941826_ChIP-Seq_K562_Human2.15344306
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11534861
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.08617578
39VDR_24763502_ChIP-Seq_THP-1_Human2.05297070
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.02393338
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.98311928
42* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.97685589
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.97408541
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96799208
45MYC_22102868_ChIP-Seq_BL_Human1.95827290
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.94306570
47* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.91797025
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.85336971
49NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.82012331
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79964403
51* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.77513866
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77041438
53* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.73762049
54GATA3_27048872_Chip-Seq_THYMUS_Human1.73674749
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72915261
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.72551644
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.71356075
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.70703069
59GATA2_19941826_ChIP-Seq_K562_Human1.70037506
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69841279
61* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.67840846
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65719343
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.65607609
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64897521
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63277869
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61842229
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59324654
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.56794332
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53974416
70SCL_19346495_ChIP-Seq_HPC-7_Human1.53095044
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52885435
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52272576
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51418124
74IRF1_19129219_ChIP-ChIP_H3396_Human1.50888627
75* GATA2_21666600_ChIP-Seq_HMVEC_Human1.47852262
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44706231
77* MAF_26560356_Chip-Seq_TH2_Human1.43939073
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41695111
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40823427
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39557001
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.33881263
82POU5F1_16518401_ChIP-PET_MESCs_Mouse1.32696861
83KDM2B_26808549_Chip-Seq_DND41_Human1.32159078
84TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.31723017
85TCF7_22412390_ChIP-Seq_EML_Mouse1.30927558
86CDX2_20551321_ChIP-Seq_CACO-2_Human1.29635425
87* GATA3_26560356_Chip-Seq_TH2_Human1.29462999
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27814007
89POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.27742147
90MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27417141
91NANOG_18692474_ChIP-Seq_MEFs_Mouse1.27396626
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26341230
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25777232
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25766467
95NANOG_18692474_ChIP-Seq_MESCs_Mouse1.25176690
96OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24182024
97* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23776526
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18461290
99* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17101136
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16952483
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15907180
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15400290
103VDR_24787735_ChIP-Seq_THP-1_Human1.14965423
104ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14494651
105PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.14020494
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13643337
107E2F1_17053090_ChIP-ChIP_MCF-7_Human1.13417288
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13389079
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12487899
110NCOR1_26117541_ChIP-Seq_K562_Human1.12028510
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11219484
112EGR1_19374776_ChIP-ChIP_THP-1_Human1.10794022
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10513146
114CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10299379
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10000938
116BCL6_27268052_Chip-Seq_Bcells_Human1.07902029
117ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07848288
118SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07803939
119KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06888670
120CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06435992
121TP63_17297297_ChIP-ChIP_HaCaT_Human1.05975052
122PU_27001747_Chip-Seq_BMDM_Mouse1.05594489
123SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05512374
124SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03066172
125ELK3_25401928_ChIP-Seq_HUVEC_Human1.01993904
126SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01770614
127* BCOR_27268052_Chip-Seq_Bcells_Human1.00562848
128TP53_22127205_ChIP-Seq_IMR90_Human0.99666864
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.99449618
130ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99055069
131SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98514661
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96446834
133* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96023935
134CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94641697
135* SPI1_20517297_ChIP-Seq_HL60_Human0.93676869
136GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92541628
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.92383071
138NANOG_16518401_ChIP-PET_MESCs_Mouse0.92131006
139* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91018674
140VDR_21846776_ChIP-Seq_THP-1_Human0.90941150
141EST1_17652178_ChIP-ChIP_JURKAT_Human0.90370984
142KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90197255
143FOXP3_21729870_ChIP-Seq_TREG_Human0.89852222
144E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89842447
145* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89341866
146PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88938147
147* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88217938
148KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86795137
149* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85773881
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85098490
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.84775164
152TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83748832
153LXR_22292898_ChIP-Seq_THP-1_Human0.83680114
154NANOG_16153702_ChIP-ChIP_HESCs_Human0.82740761
155* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81933455
156ELF1_20517297_ChIP-Seq_JURKAT_Human0.81407532
157STAT1_20625510_ChIP-Seq_HELA_Human0.80656981
158STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80093577
159* SPI1_23547873_ChIP-Seq_NB4_Human0.79638050
160YY1_22570637_ChIP-Seq_MALME-3M_Human0.79419644
161NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78904174
162* RUNX1_22412390_ChIP-Seq_EML_Mouse0.78476135
163E2F1_18555785_ChIP-Seq_MESCs_Mouse0.78429562
164MYB_26560356_Chip-Seq_TH1_Human0.77812297
165TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.76778227
166CIITA_25753668_ChIP-Seq_RAJI_Human0.76281096
167* CTCF_21964334_Chip-Seq_Bcells_Human0.75002412
168SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74373290
169KAP1_27257070_Chip-Seq_ESCs_Mouse0.74023896
170* RACK7_27058665_Chip-Seq_MCF-7_Human0.73542703
171SPI1_23127762_ChIP-Seq_K562_Human0.73412430
172KDM5A_27292631_Chip-Seq_BREAST_Human0.72398390
173RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.71442372
174XRN2_22483619_ChIP-Seq_HELA_Human0.70878038
175KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.70484025
176MAF_26560356_Chip-Seq_TH1_Human0.69517922
177KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.69421419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.83554108
2MP0003011_delayed_dark_adaptation4.51311437
3MP0004264_abnormal_extraembryonic_tissu4.45827732
4MP0002254_reproductive_system_inflammat4.35870449
5MP0006292_abnormal_olfactory_placode3.89641533
6MP0005075_abnormal_melanosome_morpholog3.76552956
7MP0003724_increased_susceptibility_to3.73975727
8MP0005394_taste/olfaction_phenotype3.09286633
9MP0005499_abnormal_olfactory_system3.09286633
10MP0008057_abnormal_DNA_replication3.07326415
11MP0004858_abnormal_nervous_system3.05359067
12MP0003890_abnormal_embryonic-extraembry2.98936323
13MP0003303_peritoneal_inflammation2.89394450
14MP0004957_abnormal_blastocyst_morpholog2.80883360
15MP0000465_gastrointestinal_hemorrhage2.65523088
16MP0000685_abnormal_immune_system2.57371016
17MP0002723_abnormal_immune_serum2.55192557
18MP0010352_gastrointestinal_tract_polyps2.54647633
19MP0002332_abnormal_exercise_endurance2.50019936
20MP0002452_abnormal_antigen_presenting2.47235629
21MP0003705_abnormal_hypodermis_morpholog2.43164404
22MP0002148_abnormal_hypersensitivity_rea2.42609263
23MP0003183_abnormal_peptide_metabolism2.40364726
24MP0002419_abnormal_innate_immunity2.37978568
25MP0010155_abnormal_intestine_physiology2.37882746
26MP0005025_abnormal_response_to2.36723043
27MP0003122_maternal_imprinting2.36178802
28MP0005257_abnormal_intraocular_pressure2.35737979
29MP0001819_abnormal_immune_cell2.33057246
30MP0002420_abnormal_adaptive_immunity2.32582376
31MP0003866_abnormal_defecation2.30848863
32MP0009785_altered_susceptibility_to2.27969003
33MP0003300_gastrointestinal_ulcer2.20014178
34MP0006082_CNS_inflammation2.19373121
35MP0006035_abnormal_mitochondrial_morpho2.18609786
36MP0008004_abnormal_stomach_pH2.16290413
37MP0002396_abnormal_hematopoietic_system2.11713038
38MP0004947_skin_inflammation1.94639463
39MP0001533_abnormal_skeleton_physiology1.93311464
40MP0003121_genomic_imprinting1.91229275
41MP0002653_abnormal_ependyma_morphology1.84156192
42MP0000678_abnormal_parathyroid_gland1.80067434
43MP0008961_abnormal_basal_metabolism1.78893970
44MP0001845_abnormal_inflammatory_respons1.75621969
45MP0002277_abnormal_respiratory_mucosa1.73980229
46MP0005380_embryogenesis_phenotype1.73735384
47MP0001672_abnormal_embryogenesis/_devel1.73735384
48MP0004510_myositis1.71996473
49MP0003938_abnormal_ear_development1.65811266
50MP0000343_altered_response_to1.65569283
51MP0002088_abnormal_embryonic_growth/wei1.64977267
52MP0001849_ear_inflammation1.64242792
53MP0003984_embryonic_growth_retardation1.62927296
54MP0000490_abnormal_crypts_of1.56396919
55MP0003077_abnormal_cell_cycle1.48776694
56MP0000350_abnormal_cell_proliferation1.46787761
57MP0004883_abnormal_blood_vessel1.40472782
58MP0001293_anophthalmia1.37622058
59MP0002998_abnormal_bone_remodeling1.35732738
60MP0002127_abnormal_cardiovascular_syste1.35009730
61MP0005058_abnormal_lysosome_morphology1.31316315
62MP0002092_abnormal_eye_morphology1.29951215
63MP0002086_abnormal_extraembryonic_tissu1.29041036
64MP0001851_eye_inflammation1.28576189
65MP0009278_abnormal_bone_marrow1.25527516
66MP0004381_abnormal_hair_follicle1.24038034
67MP0002932_abnormal_joint_morphology1.22035803
68MP0003566_abnormal_cell_adhesion1.20409187
69MP0005397_hematopoietic_system_phenotyp1.19486729
70MP0001545_abnormal_hematopoietic_system1.19486729
71MP0009764_decreased_sensitivity_to1.18542055
72MP0001873_stomach_inflammation1.16838139
73MP0000249_abnormal_blood_vessel1.15536917
74MP0005266_abnormal_metabolism1.15482874
75MP0003123_paternal_imprinting1.15373419
76MP0003111_abnormal_nucleus_morphology1.15130568
77MP0003191_abnormal_cellular_cholesterol1.12644747
78MP0002132_abnormal_respiratory_system1.12420248
79MP0008469_abnormal_protein_level1.11534587
80MP0003690_abnormal_glial_cell1.11032604
81MP0000762_abnormal_tongue_morphology1.10965190
82MP0002085_abnormal_embryonic_tissue1.10358727
83MP0010030_abnormal_orbit_morphology1.10061015
84MP0001663_abnormal_digestive_system1.08106900
85MP0000313_abnormal_cell_death1.06801504
86MP0002970_abnormal_white_adipose1.06293445
87MP0002166_altered_tumor_susceptibility1.03011287
88MP0008789_abnormal_olfactory_epithelium1.02018498
89MP0010094_abnormal_chromosome_stability1.01662274
90MP0009763_increased_sensitivity_to1.00686943
91MP0005166_decreased_susceptibility_to0.99820320
92MP0002138_abnormal_hepatobiliary_system0.99061152
93MP0003453_abnormal_keratinocyte_physiol0.97559879
94MP0008770_decreased_survivor_rate0.96646349
95MP0001348_abnormal_lacrimal_gland0.96628717
96MP0000689_abnormal_spleen_morphology0.95234654
97MP0002722_abnormal_immune_system0.95072538
98MP0008260_abnormal_autophagy0.94815663
99MP0000049_abnormal_middle_ear0.93106104
100MP0002084_abnormal_developmental_patter0.92676573
101MP0004043_abnormal_pH_regulation0.92127248
102MP0003172_abnormal_lysosome_physiology0.91151090
103MP0002114_abnormal_axial_skeleton0.90503377
104MP0003693_abnormal_embryo_hatching0.89465451
105MP0003656_abnormal_erythrocyte_physiolo0.88880827
106MP0000604_amyloidosis0.88638348
107MP0005023_abnormal_wound_healing0.88463892
108MP0003075_altered_response_to0.88244677
109MP0001730_embryonic_growth_arrest0.88004147
110MP0000428_abnormal_craniofacial_morphol0.85913465
111MP0005167_abnormal_blood-brain_barrier0.84274463
112MP0001800_abnormal_humoral_immune0.84100157
113MP0005451_abnormal_body_composition0.83989680
114MP0002233_abnormal_nose_morphology0.83489933
115MP0005164_abnormal_response_to0.83316979
116MP0004130_abnormal_muscle_cell0.82950067
117MP0002080_prenatal_lethality0.81190738
118MP0004197_abnormal_fetal_growth/weight/0.80479288
119MP0008007_abnormal_cellular_replicative0.80227085
120MP0002796_impaired_skin_barrier0.79385367
121MP0005671_abnormal_response_to0.79095160
122MP0000432_abnormal_head_morphology0.79065094
123MP0003436_decreased_susceptibility_to0.79029033
124MP0001697_abnormal_embryo_size0.78980917
125MP0002405_respiratory_system_inflammati0.78918362
126MP0002398_abnormal_bone_marrow0.78457508
127MP0003315_abnormal_perineum_morphology0.77728242
128MP0002429_abnormal_blood_cell0.77227135
129MP0001835_abnormal_antigen_presentation0.77183414
130MP0003329_amyloid_beta_deposits0.76906694
131MP0005083_abnormal_biliary_tract0.75727128
132MP0002019_abnormal_tumor_incidence0.75700349
133MP0003448_altered_tumor_morphology0.74922816
134MP0002925_abnormal_cardiovascular_devel0.74819462
135MP0008874_decreased_physiological_sensi0.73980019
136MP0000015_abnormal_ear_pigmentation0.73536514
137MP0009333_abnormal_splenocyte_physiolog0.73056288
138MP0000716_abnormal_immune_system0.71973037
139MP0001790_abnormal_immune_system0.71872922
140MP0005387_immune_system_phenotype0.71872922
141MP0005310_abnormal_salivary_gland0.71223886
142MP0003935_abnormal_craniofacial_develop0.71177535
143MP0001986_abnormal_taste_sensitivity0.71159722
144MP0000358_abnormal_cell_content/0.70637737
145MP0001765_abnormal_ion_homeostasis0.69959044
146MP0005391_vision/eye_phenotype0.69013983
147MP0003638_abnormal_response/metabolism_0.68181729
148MP0005409_darkened_coat_color0.67485400
149MP0005390_skeleton_phenotype0.67470408
150MP0003879_abnormal_hair_cell0.66508500
151MP0003119_abnormal_digestive_system0.66376332
152MP0008932_abnormal_embryonic_tissue0.66277378
153MP0005165_increased_susceptibility_to0.65884486
154MP0000377_abnormal_hair_follicle0.65840674
155MP0000858_altered_metastatic_potential0.65616724
156MP0003795_abnormal_bone_structure0.65558726
157MP0005000_abnormal_immune_tolerance0.64909754
158MP0000703_abnormal_thymus_morphology0.64737551
159MP0009765_abnormal_xenobiotic_induced0.63637904
160MP0003828_pulmonary_edema0.63620031
161MP0001853_heart_inflammation0.63333459
162MP0005381_digestive/alimentary_phenotyp0.63329852
163MP0002933_joint_inflammation0.62805617
164MP0003091_abnormal_cell_migration0.62514886
165MP0003045_fibrosis0.61981367
166MP0005508_abnormal_skeleton_morphology0.61632033
167MP0005666_abnormal_adipose_tissue0.61385897
168MP0005501_abnormal_skin_physiology0.61172814
169MP0009840_abnormal_foam_cell0.60733915
170MP0009703_decreased_birth_body0.60560511
171MP0002098_abnormal_vibrissa_morphology0.60439625
172MP0003763_abnormal_thymus_physiology0.59975026
173MP0002136_abnormal_kidney_physiology0.59811257

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.35024896
2Prolonged bleeding time (HP:0003010)6.84865516
3Hypochromic microcytic anemia (HP:0004840)6.01241492
4Petechiae (HP:0000967)5.96804859
5Eczematoid dermatitis (HP:0000976)5.82543293
6Purpura (HP:0000979)5.61782372
7Multiple enchondromatosis (HP:0005701)5.54454631
8Abnormal platelet volume (HP:0011876)5.20106785
9Epistaxis (HP:0000421)5.16360191
10Hepatoblastoma (HP:0002884)5.15632890
11Menorrhagia (HP:0000132)5.04726881
12Increased mean platelet volume (HP:0011877)4.95745730
13Abnormality of the lower motor neuron (HP:0002366)4.81818518
14Gingival bleeding (HP:0000225)4.55059974
15Rib fusion (HP:0000902)4.49246734
16Ependymoma (HP:0002888)4.40934558
17Spontaneous hematomas (HP:0007420)4.26961739
18Recurrent bacterial skin infections (HP:0005406)4.10097860
19Abnormality of macrophages (HP:0004311)4.07199876
20Recurrent abscess formation (HP:0002722)3.88312399
21Chronic obstructive pulmonary disease (HP:0006510)3.81184112
22Obstructive lung disease (HP:0006536)3.81184112
23Abnormal platelet function (HP:0011869)3.77320839
24Impaired platelet aggregation (HP:0003540)3.77320839
25Neoplasm of striated muscle (HP:0009728)3.73409179
26Meningitis (HP:0001287)3.55656098
27Agammaglobulinemia (HP:0004432)3.54943393
28Rhabdomyosarcoma (HP:0002859)3.54895920
29Nephroblastoma (Wilms tumor) (HP:0002667)3.47895817
30Rectal fistula (HP:0100590)3.38253873
31Rectovaginal fistula (HP:0000143)3.38253873
32Partial duplication of thumb phalanx (HP:0009944)3.36587508
33Recurrent fungal infections (HP:0002841)3.34762190
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.34750438
35Testicular atrophy (HP:0000029)3.31426134
36Chromosomal breakage induced by crosslinking agents (HP:0003221)3.31400124
37Ragged-red muscle fibers (HP:0003200)3.27188876
38Vasculitis (HP:0002633)3.22542083
39Aplasia/Hypoplasia of the fovea (HP:0008060)3.20315098
40Hypoplasia of the fovea (HP:0007750)3.20315098
41Embryonal renal neoplasm (HP:0011794)3.19992633
42Intestinal fistula (HP:0100819)3.15437961
43Amyotrophic lateral sclerosis (HP:0007354)3.15152066
44Abnormality of the salivary glands (HP:0010286)3.13208863
45Fused cervical vertebrae (HP:0002949)3.13137474
46T lymphocytopenia (HP:0005403)3.11474735
47Abnormality of T cell number (HP:0011839)3.07770478
48Encephalitis (HP:0002383)3.06063163
49Panhypogammaglobulinemia (HP:0003139)3.05650803
50Reduced antithrombin III activity (HP:0001976)3.03892720
51Myositis (HP:0100614)3.03620588
52Increased IgE level (HP:0003212)3.03538514
53Trismus (HP:0000211)3.01630667
54Vaginal fistula (HP:0004320)2.99113742
55Astrocytoma (HP:0009592)2.98541621
56Abnormality of the astrocytes (HP:0100707)2.98541621
57Joint swelling (HP:0001386)2.96059921
58Pustule (HP:0200039)2.94247816
59Chronic mucocutaneous candidiasis (HP:0002728)2.94014336
60Recurrent cutaneous fungal infections (HP:0011370)2.94014336
61Gastrointestinal stroma tumor (HP:0100723)2.91713235
62Recurrent skin infections (HP:0001581)2.91019216
63Recurrent viral infections (HP:0004429)2.89389953
64Partial duplication of the phalanx of hand (HP:0009999)2.88862269
65Inflammation of the large intestine (HP:0002037)2.86763080
66Abnormal cartilage morphology (HP:0002763)2.85240525
67Chromsome breakage (HP:0040012)2.84823805
68Hypochromic anemia (HP:0001931)2.84505646
69Increased IgM level (HP:0003496)2.83979569
70Anomalous pulmonary venous return (HP:0010772)2.83763038
71Aplasia/hypoplasia of the humerus (HP:0006507)2.83503045
72Hyperlipoproteinemia (HP:0010980)2.83333797
73Chest pain (HP:0100749)2.82861192
74Bifid tongue (HP:0010297)2.82514894
75Abnormality of T cells (HP:0002843)2.82469065
76Orchitis (HP:0100796)2.81317065
77Stomatitis (HP:0010280)2.78748732
78Preauricular skin tag (HP:0000384)2.77877973
79Short humerus (HP:0005792)2.77868788
80Cellulitis (HP:0100658)2.76735538
81Gastrointestinal inflammation (HP:0004386)2.76138308
82Mediastinal lymphadenopathy (HP:0100721)2.75612641
83Nasal polyposis (HP:0100582)2.74671206
84IgG deficiency (HP:0004315)2.74483072
85Horizontal nystagmus (HP:0000666)2.73589876
86Abnormal lung lobation (HP:0002101)2.71072254
87Hyperinsulinemic hypoglycemia (HP:0000825)2.70696624
88Colitis (HP:0002583)2.68987886
89Gastrointestinal infarctions (HP:0005244)2.68718670
90Granulocytopenia (HP:0001913)2.67207715
91Retrobulbar optic neuritis (HP:0100654)2.63793190
92Optic neuritis (HP:0100653)2.63793190
93Abnormality of the prostate (HP:0008775)2.63664210
94Osteomyelitis (HP:0002754)2.56843387
95Abnormality of T cell physiology (HP:0011840)2.55437590
96Abnormality of glycolipid metabolism (HP:0010969)2.55398058
97Abnormality of liposaccharide metabolism (HP:0010968)2.55398058
98Abnormality of glycosphingolipid metabolism (HP:0004343)2.55398058
99IgM deficiency (HP:0002850)2.52978458
100Cheilitis (HP:0100825)2.50897617
101Progressive muscle weakness (HP:0003323)2.50048559
102Skin tags (HP:0010609)2.49967894
103Autoimmune hemolytic anemia (HP:0001890)2.46276651
104Systemic lupus erythematosus (HP:0002725)2.45306661
105Leukocytosis (HP:0001974)2.44781460
106Papilloma (HP:0012740)2.44227711
107Verrucae (HP:0200043)2.44227711
108Villous atrophy (HP:0011473)2.43933392
109Abnormality of small intestinal villus morphology (HP:0011472)2.43933392
110Generalized hypotonia (HP:0001290)2.43502077
111Large earlobe (HP:0009748)2.41789249
112Recurrent bronchitis (HP:0002837)2.41632108
113Preauricular pit (HP:0004467)2.41494023
114Periauricular skin pits (HP:0100277)2.41494023
115Combined immunodeficiency (HP:0005387)2.40957989
116Urticaria (HP:0001025)2.39953452
117Abnormality of the fovea (HP:0000493)2.39370465
118Recurrent gram-negative bacterial infections (HP:0005420)2.37383974
119Lymphopenia (HP:0001888)2.36580072
120Abnormality of the pulmonary veins (HP:0011718)2.36448581
121Microretrognathia (HP:0000308)2.36415366
122Chronic diarrhea (HP:0002028)2.35713817
123Tongue fasciculations (HP:0001308)2.34537651
124Abnormality of the nasal mucosa (HP:0000433)2.33792842
125Tetraplegia (HP:0002445)2.33753010
126Upper motor neuron abnormality (HP:0002127)2.33122643
127Arterial thrombosis (HP:0004420)2.32192178
128Hemoptysis (HP:0002105)2.31671067
129Eosinophilia (HP:0001880)2.31434019
130Abnormality of cells of the lymphoid lineage (HP:0012140)2.28026764
131Meckel diverticulum (HP:0002245)2.26866449
132Recurrent sinusitis (HP:0011108)2.25739304
133Impulsivity (HP:0100710)2.24749045
134Bruising susceptibility (HP:0000978)2.24357830
135Abnormality of the phalanges of the hallux (HP:0010057)2.22899122
136Abnormality of the distal phalanx of the thumb (HP:0009617)2.21889253
137Aplastic anemia (HP:0001915)2.20645625
138Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19473171
139Gingivitis (HP:0000230)2.16822269
140Hand muscle atrophy (HP:0009130)2.16508876
141Pendular nystagmus (HP:0012043)2.16147981
142Glioma (HP:0009733)2.15809292
143Abnormality of the musculature of the hand (HP:0001421)2.15415547
144Glossoptosis (HP:0000162)2.15029088
145Abnormality of the ileum (HP:0001549)2.14117142
146Acanthocytosis (HP:0001927)2.14010465
147IgA deficiency (HP:0002720)2.13663624
148Growth hormone excess (HP:0000845)2.12911732
149Atrophy/Degeneration involving motor neurons (HP:0007373)2.12597067
150Pulmonary infiltrates (HP:0002113)2.12125759
151Short 5th finger (HP:0009237)2.11761542
152Neoplasm of the heart (HP:0100544)2.11273091
153Nasolacrimal duct obstruction (HP:0000579)2.10921285
154Glomerulonephritis (HP:0000099)2.10732289
155Emphysema (HP:0002097)2.10448538
156Seborrheic dermatitis (HP:0001051)2.10313172
157Aplasia/Hypoplasia of the uvula (HP:0010293)2.09619500
158Skin rash (HP:0000988)2.09409826
159Muscle fibrillation (HP:0010546)2.08691604
160Increased connective tissue (HP:0009025)2.07479236
161Difficulty running (HP:0009046)2.07125473
162Renal duplication (HP:0000075)2.06772686
163Shawl scrotum (HP:0000049)2.06290291
164Elevated erythrocyte sedimentation rate (HP:0003565)2.05953481
165Sensory axonal neuropathy (HP:0003390)2.05693324
166Abnormality of iron homeostasis (HP:0011031)2.05395970
167Abnormality of chromosome segregation (HP:0002916)2.05307091
168Keratoconjunctivitis sicca (HP:0001097)2.04946838
169Aplasia/Hypoplasia of the macula (HP:0008059)2.04498216
170Arthralgia (HP:0002829)2.03879824
171Hypopigmentation of the fundus (HP:0007894)2.03770770
172Restrictive lung disease (HP:0002091)2.03501309
173Abnormality of B cell number (HP:0010975)2.03417087
174Increased serum ferritin (HP:0003281)2.03237309
175Thick nail (HP:0001805)2.02716649
176Pulmonary embolism (HP:0002204)2.02139158
177Type I transferrin isoform profile (HP:0003642)2.01196965
178Autoimmune thrombocytopenia (HP:0001973)2.00512130
179Hepatosplenomegaly (HP:0001433)2.00311732
180Poikilocytosis (HP:0004447)1.99452258
181Hyperventilation (HP:0002883)1.99110790
182Sepsis (HP:0100806)1.98848255
183Malignant neoplasm of the central nervous system (HP:0100836)1.98792176
184Gangrene (HP:0100758)1.97691617
185Malnutrition (HP:0004395)1.97431683
186Fasciculations (HP:0002380)1.97354003
187Abnormality of the pubic bones (HP:0003172)1.97201141
188Hypergammaglobulinemia (HP:0010702)1.96398206
189Abnormality of eosinophils (HP:0001879)1.94600219
190Skin pits (HP:0100276)1.92159664
191Global brain atrophy (HP:0002283)1.91827147
192Hypoplastic scapulae (HP:0000882)1.90969063
193Aplasia/Hypoplasia of the scapulae (HP:0006713)1.90969063
194Cerebral palsy (HP:0100021)1.90447590
195Abnormality of the common coagulation pathway (HP:0010990)1.90421041
196Microvesicular hepatic steatosis (HP:0001414)1.90076370
197Medulloblastoma (HP:0002885)1.89387336
198Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.88076767
199Prostate neoplasm (HP:0100787)1.86982532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.15253347
2RIPK46.76461446
3GRK55.10610265
4ERN14.86747162
5GRK64.76592235
6ADRBK23.38183073
7CSF1R3.37171958
8GRK13.04977594
9TGFBR23.01439131
10STK102.58213158
11BMPR22.47496642
12BTK2.45196250
13MATK2.38419866
14TYRO32.35245593
15GRK72.34584383
16MAPK72.20857023
17MAP3K132.20713508
18TTK2.19475711
19TXK1.97125394
20MOS1.89491692
21FES1.79858096
22TEC1.76925130
23JAK31.75158931
24TAOK31.70441445
25WNK11.65859098
26IRAK41.61385687
27PRPF4B1.61209431
28PRKG21.55862464
29CDK71.51880508
30MAP3K141.44856543
31CAMK41.42203920
32MAP3K101.40008957
33JAK11.37612620
34FGR1.36505682
35PAK41.34725883
36LYN1.34237868
37MARK21.27325726
38NTRK11.23785184
39EPHA21.19753238
40SIK31.18977623
41HIPK21.18618044
42FGFR31.10280646
43MAP3K31.04452469
44KSR21.01642533
45CSK0.98925541
46CHEK20.98298083
47EPHB10.98163206
48ADRBK10.95590016
49IKBKE0.95271057
50MAP2K20.94075638
51MAP4K10.93885929
52TBK10.91286570
53MAP3K10.89762495
54PLK10.87506986
55MAP2K40.87280227
56PIK3CA0.85061949
57MAP2K60.83454696
58PDPK10.83048433
59AKT30.80460183
60PIK3CG0.79909599
61ALK0.78188280
62MARK30.77678937
63ARAF0.77469476
64MAP3K70.74389043
65MAP3K110.72953905
66PTK2B0.72836067
67CDC42BPA0.72062030
68MAPK120.70696525
69PRKCQ0.69673921
70RET0.69616570
71ITK0.68921631
72MAPK110.67510231
73SMG10.66642226
74BLK0.66301382
75AKT20.66074397
76FYN0.64920015
77RIPK10.64572973
78CHEK10.63882557
79EIF2AK10.62874406
80NEK20.60485880
81MAP2K10.58966228
82YES10.57822292
83IKBKB0.54340666
84MAP3K20.53388530
85RPS6KB20.53290253
86TAOK20.53027520
87KIT0.52121941
88STK240.51507891
89MYLK0.49578809
90PDGFRB0.48607000
91TLK10.48276417
92FGFR40.47323771
93EIF2AK20.45939023
94MTOR0.45776557
95IGF1R0.43880653
96CDK40.43370990
97CDC70.42645710
98TESK20.38402553
99PRKCI0.37968649
100CDK20.37682349
101IRAK10.37618707
102FLT30.37578607
103MAPKAPK30.37228439
104WEE10.36814469
105RAF10.36489514
106PTK60.36451062
107PRKCD0.35560811
108SGK30.35119168
109ZAP700.32969088
110MAP3K90.31970928
111NLK0.31860995
112IRAK30.31528562
113SIK10.31492805
114BUB10.30826580
115KDR0.30407981
116PAK10.30391506
117ACVR1B0.29225495
118PRKD10.29009629
119PTK20.28839492
120AURKA0.28282263
121BMX0.27144536
122MAPK40.27102199
123RPS6KC10.26889852
124AURKB0.26470930
125HCK0.26247337
126MST40.24004145
127LCK0.23888956
128ATM0.23817374
129EEF2K0.21025514
130INSR0.19876369
131SYK0.19720530
132TRIB30.18689940
133MAPK100.18655311
134TAOK10.18522109
135ERBB20.18340798
136MAPKAPK20.18335382
137CHUK0.17758940
138SIK20.17229390
139MAPK10.16353796
140TYK20.15860544
141PRKD20.14930746
142CSNK1E0.13935974
143DYRK30.13862130
144MAP3K80.13722184
145CDK10.13502158
146PIM10.13163923
147PRKACG0.12465041
148MAPK140.11586464
149TNK20.11367534
150MAP2K30.11069802
151PDGFRA0.10682674
152GSK3A0.10140483
153GSK3B0.10001501
154LRRK20.09633683
155PDK10.09362817
156LATS20.09245883
157JAK20.08446287

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.89666726
2Vitamin B6 metabolism_Homo sapiens_hsa007505.89552492
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.84735710
4Fructose and mannose metabolism_Homo sapiens_hsa000513.68934013
5Allograft rejection_Homo sapiens_hsa053302.89202630
6Graft-versus-host disease_Homo sapiens_hsa053322.85784052
7Galactose metabolism_Homo sapiens_hsa000522.78587540
8Autoimmune thyroid disease_Homo sapiens_hsa053202.77919874
9Staphylococcus aureus infection_Homo sapiens_hsa051502.68862629
10Arachidonic acid metabolism_Homo sapiens_hsa005902.48626048
11Platelet activation_Homo sapiens_hsa046112.35506338
12Asthma_Homo sapiens_hsa053102.24576678
13Osteoclast differentiation_Homo sapiens_hsa043802.16326828
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.07915831
15Type I diabetes mellitus_Homo sapiens_hsa049402.01240269
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92504741
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90045570
18Other glycan degradation_Homo sapiens_hsa005111.88774212
19Linoleic acid metabolism_Homo sapiens_hsa005911.83613583
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79455501
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.75652284
22Chemokine signaling pathway_Homo sapiens_hsa040621.75646121
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73693079
24DNA replication_Homo sapiens_hsa030301.63874173
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.63352411
26Viral myocarditis_Homo sapiens_hsa054161.61234285
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58514817
28Thyroid cancer_Homo sapiens_hsa052161.57343030
29RNA transport_Homo sapiens_hsa030131.56522194
30Tuberculosis_Homo sapiens_hsa051521.53435491
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48768469
32mTOR signaling pathway_Homo sapiens_hsa041501.46059811
33Measles_Homo sapiens_hsa051621.40384100
34Ribosome_Homo sapiens_hsa030101.39373069
35Mismatch repair_Homo sapiens_hsa034301.32975546
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28129838
37Primary immunodeficiency_Homo sapiens_hsa053401.23624153
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15946408
39Fanconi anemia pathway_Homo sapiens_hsa034601.14739083
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14260877
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13382361
42Malaria_Homo sapiens_hsa051441.12410365
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12036759
44Phagosome_Homo sapiens_hsa041451.09083929
45Rheumatoid arthritis_Homo sapiens_hsa053231.08772382
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05575021
47mRNA surveillance pathway_Homo sapiens_hsa030151.05422192
48Acute myeloid leukemia_Homo sapiens_hsa052211.04168788
49Cell cycle_Homo sapiens_hsa041101.03825952
50Systemic lupus erythematosus_Homo sapiens_hsa053221.01748862
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98036695
52Pentose phosphate pathway_Homo sapiens_hsa000300.97973694
53Homologous recombination_Homo sapiens_hsa034400.97133500
54TNF signaling pathway_Homo sapiens_hsa046680.96103963
55One carbon pool by folate_Homo sapiens_hsa006700.95391672
56Shigellosis_Homo sapiens_hsa051310.94067066
57Inositol phosphate metabolism_Homo sapiens_hsa005620.93438699
58Folate biosynthesis_Homo sapiens_hsa007900.93350442
59Chronic myeloid leukemia_Homo sapiens_hsa052200.93106201
60Base excision repair_Homo sapiens_hsa034100.88963121
61RNA degradation_Homo sapiens_hsa030180.87630387
62Herpes simplex infection_Homo sapiens_hsa051680.87263049
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86838926
64Hepatitis B_Homo sapiens_hsa051610.83651157
65Endocytosis_Homo sapiens_hsa041440.82111915
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.81248507
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81075637
68B cell receptor signaling pathway_Homo sapiens_hsa046620.80961137
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79379163
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78915716
71Spliceosome_Homo sapiens_hsa030400.77814171
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.77264323
73p53 signaling pathway_Homo sapiens_hsa041150.77215336
74Renin-angiotensin system_Homo sapiens_hsa046140.76634158
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75929489
76Pertussis_Homo sapiens_hsa051330.74807683
77Sulfur relay system_Homo sapiens_hsa041220.72298021
78Non-small cell lung cancer_Homo sapiens_hsa052230.70856909
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.70690141
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.69623195
81Leishmaniasis_Homo sapiens_hsa051400.69385610
82Apoptosis_Homo sapiens_hsa042100.68462572
83Renal cell carcinoma_Homo sapiens_hsa052110.68456141
84Hepatitis C_Homo sapiens_hsa051600.68387344
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68293253
86Salmonella infection_Homo sapiens_hsa051320.67193221
87T cell receptor signaling pathway_Homo sapiens_hsa046600.66177729
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65263513
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65059711
90Chemical carcinogenesis_Homo sapiens_hsa052040.64537681
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63118680
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58184828
93MicroRNAs in cancer_Homo sapiens_hsa052060.57202182
94Choline metabolism in cancer_Homo sapiens_hsa052310.55639456
95African trypanosomiasis_Homo sapiens_hsa051430.55614312
96Epstein-Barr virus infection_Homo sapiens_hsa051690.55401799
97Ovarian steroidogenesis_Homo sapiens_hsa049130.55062701
98* Pathways in cancer_Homo sapiens_hsa052000.54178724
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.54100725
100Antigen processing and presentation_Homo sapiens_hsa046120.53150076
101VEGF signaling pathway_Homo sapiens_hsa043700.52646281
102Ether lipid metabolism_Homo sapiens_hsa005650.52403935
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51664003
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51266912
105Notch signaling pathway_Homo sapiens_hsa043300.50090996
106Lysosome_Homo sapiens_hsa041420.49980336
107Endometrial cancer_Homo sapiens_hsa052130.48731855
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47381822
109Hematopoietic cell lineage_Homo sapiens_hsa046400.47146669
110Pancreatic cancer_Homo sapiens_hsa052120.47144223
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46345688
112* Phospholipase D signaling pathway_Homo sapiens_hsa040720.45451986
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45434794
114Prolactin signaling pathway_Homo sapiens_hsa049170.44790362
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43928567
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.43794678
117RNA polymerase_Homo sapiens_hsa030200.43765975
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.43327705
119GnRH signaling pathway_Homo sapiens_hsa049120.42674963
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38659826
121Glioma_Homo sapiens_hsa052140.37961072
122Gap junction_Homo sapiens_hsa045400.36847288
123HTLV-I infection_Homo sapiens_hsa051660.36453611
124Amoebiasis_Homo sapiens_hsa051460.35476364
125Pancreatic secretion_Homo sapiens_hsa049720.34984070
126Influenza A_Homo sapiens_hsa051640.34952549
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34895832
128HIF-1 signaling pathway_Homo sapiens_hsa040660.34463323
129Basal cell carcinoma_Homo sapiens_hsa052170.33696417
130Complement and coagulation cascades_Homo sapiens_hsa046100.33343634
131Legionellosis_Homo sapiens_hsa051340.32550401
132Viral carcinogenesis_Homo sapiens_hsa052030.32324159
133Colorectal cancer_Homo sapiens_hsa052100.32177893
134Ras signaling pathway_Homo sapiens_hsa040140.31989417
135Proteoglycans in cancer_Homo sapiens_hsa052050.30758529
136* Rap1 signaling pathway_Homo sapiens_hsa040150.29935061
137Long-term potentiation_Homo sapiens_hsa047200.29919707
138Long-term depression_Homo sapiens_hsa047300.29662891
139Regulation of autophagy_Homo sapiens_hsa041400.29272150
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.29062340
141Bladder cancer_Homo sapiens_hsa052190.29049933
142ErbB signaling pathway_Homo sapiens_hsa040120.28989436
143Pyrimidine metabolism_Homo sapiens_hsa002400.27788827
144Non-homologous end-joining_Homo sapiens_hsa034500.27614677
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.27487838
146Hedgehog signaling pathway_Homo sapiens_hsa043400.27014973
147Toxoplasmosis_Homo sapiens_hsa051450.26244089
148Biosynthesis of amino acids_Homo sapiens_hsa012300.25823206
149Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25543319
150Basal transcription factors_Homo sapiens_hsa030220.24238159
151Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24002032

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »