LPAR6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1growth hormone receptor signaling pathway (GO:0060396)5.34682035
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.23432159
3cellular response to growth hormone stimulus (GO:0071378)4.73455046
4positive regulation of gamma-delta T cell activation (GO:0046645)4.70257132
5positive thymic T cell selection (GO:0045059)4.65304759
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.61587456
7regulation of B cell receptor signaling pathway (GO:0050855)4.29150595
8B cell mediated immunity (GO:0019724)4.15748598
9positive T cell selection (GO:0043368)4.09288169
10cellular response to ethanol (GO:0071361)3.89459197
11leukocyte degranulation (GO:0043299)3.81426470
12negative regulation of interleukin-12 production (GO:0032695)3.80435799
13response to interferon-beta (GO:0035456)3.77943612
14natural killer cell activation involved in immune response (GO:0002323)3.72414718
15negative regulation of cell killing (GO:0031342)3.58303425
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.58303425
17antigen processing and presentation of endogenous antigen (GO:0019883)3.56905053
18negative regulation of thymocyte apoptotic process (GO:0070244)3.55986126
19platelet dense granule organization (GO:0060155)3.50002227
20regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.46038201
21mast cell activation involved in immune response (GO:0002279)3.32731389
22mast cell degranulation (GO:0043303)3.32731389
23positive regulation of interferon-alpha production (GO:0032727)3.31413312
24regulation of gamma-delta T cell differentiation (GO:0045586)3.29717053
25regulation of gamma-delta T cell activation (GO:0046643)3.25202137
26phagocytosis, engulfment (GO:0006911)3.24085410
27thymic T cell selection (GO:0045061)3.23700632
28mast cell activation (GO:0045576)3.23528640
29T cell selection (GO:0045058)3.23200138
30ribosomal small subunit assembly (GO:0000028)3.22059891
31definitive hemopoiesis (GO:0060216)3.20963947
32regulation of tolerance induction (GO:0002643)3.17402010
33positive regulation of T cell mediated cytotoxicity (GO:0001916)3.14029705
34neutrophil activation involved in immune response (GO:0002283)3.11686766
35pinocytosis (GO:0006907)3.11682632
36regulation of T cell tolerance induction (GO:0002664)3.10624726
37regulation of interferon-alpha production (GO:0032647)3.10017313
38response to type I interferon (GO:0034340)3.07929903
39cellular response to interferon-beta (GO:0035458)3.07576072
40antigen receptor-mediated signaling pathway (GO:0050851)3.06508108
41type I interferon signaling pathway (GO:0060337)3.06345463
42cellular response to type I interferon (GO:0071357)3.06345463
43regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04336276
44positive regulation of antigen processing and presentation (GO:0002579)3.04162877
45positive regulation of tolerance induction (GO:0002645)3.04047306
46macrophage activation involved in immune response (GO:0002281)3.02979150
47regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.02386025
48myeloid cell activation involved in immune response (GO:0002275)2.97573970
49regulation of interferon-beta biosynthetic process (GO:0045357)2.97381733
50defense response to protozoan (GO:0042832)2.95820559
51T cell receptor signaling pathway (GO:0050852)2.95288382
52response to protozoan (GO:0001562)2.92368990
53T cell migration (GO:0072678)2.92343921
54cellular response to interleukin-15 (GO:0071350)2.91177209
55JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.90649004
56detection of external biotic stimulus (GO:0098581)2.89632191
57T cell costimulation (GO:0031295)2.88948450
58detection of other organism (GO:0098543)2.88590876
59regulation of hypersensitivity (GO:0002883)2.87103160
60positive regulation of mast cell activation (GO:0033005)2.86906885
61lymphocyte costimulation (GO:0031294)2.84390549
62interferon-gamma production (GO:0032609)2.83183762
63positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.83165896
64response to peptidoglycan (GO:0032494)2.82349116
65response to interferon-alpha (GO:0035455)2.82305668
66regulation of oxidative stress-induced neuron death (GO:1903203)2.82064146
67daunorubicin metabolic process (GO:0044597)2.81096822
68polyketide metabolic process (GO:0030638)2.81096822
69doxorubicin metabolic process (GO:0044598)2.81096822
70regulation of T cell mediated cytotoxicity (GO:0001914)2.80539314
71T-helper 1 type immune response (GO:0042088)2.78842803
72regulation of antigen processing and presentation (GO:0002577)2.78838480
73regulation of germinal center formation (GO:0002634)2.78823586
74cellular response to interferon-gamma (GO:0071346)2.77882835
75regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73457117
76immunoglobulin mediated immune response (GO:0016064)2.73079418
77dendritic cell chemotaxis (GO:0002407)2.72495179
78negative T cell selection (GO:0043383)2.72170347
79negative regulation of granulocyte differentiation (GO:0030853)2.71872884
80neutrophil activation (GO:0042119)2.71767039
81response to muramyl dipeptide (GO:0032495)2.71706607
82endothelium development (GO:0003158)2.71641540
83negative regulation of phagocytosis (GO:0050765)2.69849717
84positive regulation of B cell differentiation (GO:0045579)2.69609607
85regulation of B cell differentiation (GO:0045577)2.69143896
86positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.68372442
87positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.66917558
88positive regulation of T cell migration (GO:2000406)2.66526524
89adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.66337531
90positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.65232903
91detection of molecule of bacterial origin (GO:0032490)2.64438604
92positive regulation of mast cell activation involved in immune response (GO:0033008)2.63910031
93positive regulation of mast cell degranulation (GO:0043306)2.63910031
94germinal center formation (GO:0002467)2.63467135
95chaperone mediated protein folding requiring cofactor (GO:0051085)2.63293271
96negative regulation of nitric oxide biosynthetic process (GO:0045019)2.63158169
97positive regulation of chemokine secretion (GO:0090197)2.63080774
98cellular extravasation (GO:0045123)2.62969680
99regulation of T cell migration (GO:2000404)2.62369859
100antigen processing and presentation via MHC class Ib (GO:0002475)2.62185377
101RNA destabilization (GO:0050779)2.61502872
102detection of biotic stimulus (GO:0009595)2.61049630
103negative regulation of T cell mediated immunity (GO:0002710)2.60836365
104response to interferon-gamma (GO:0034341)2.60400583
105microglial cell activation (GO:0001774)2.59167096
106dendritic cell migration (GO:0036336)2.59048096
107leukocyte aggregation (GO:0070486)2.58108354
108positive regulation of interferon-beta production (GO:0032728)2.57474672
109regulation of alpha-beta T cell proliferation (GO:0046640)2.57372877
110positive regulation of macrophage cytokine production (GO:0060907)2.57339144
111regulation of regulatory T cell differentiation (GO:0045589)2.57094080
112B cell receptor signaling pathway (GO:0050853)2.55292838
113positive regulation of macrophage differentiation (GO:0045651)2.54866898
114cellular response to exogenous dsRNA (GO:0071360)2.54327912
115respiratory burst (GO:0045730)2.53914960
116positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.53598447
117adaptive immune response (GO:0002250)2.53580017
118adenosine metabolic process (GO:0046085)2.53414284
119regulation of B cell apoptotic process (GO:0002902)2.53323584
120response to interleukin-15 (GO:0070672)2.53249872
121negative thymic T cell selection (GO:0045060)2.52207533
122response to hydroperoxide (GO:0033194)2.52064208
123regulation of macrophage chemotaxis (GO:0010758)2.50362020
124megakaryocyte development (GO:0035855)2.49433057
125cell differentiation involved in metanephros development (GO:0072202)2.48729180
126myeloid dendritic cell activation (GO:0001773)2.48365142
127lymph vessel development (GO:0001945)2.47849860
128regulation of lymphocyte migration (GO:2000401)2.47502131
129antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.47156135
130antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.47156135
131positive regulation of lymphocyte migration (GO:2000403)2.46927803
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.46133243
133positive regulation by organism of defense response of other organism involved in symbiotic interact2.46133243
134modulation by symbiont of host immune response (GO:0052553)2.46133243
135positive regulation by symbiont of host defense response (GO:0052509)2.46133243
136modulation by symbiont of host defense response (GO:0052031)2.46133243
137modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.46133243
138detection of bacterium (GO:0016045)2.45528644
139mature B cell differentiation involved in immune response (GO:0002313)2.44962306
140positive regulation of alpha-beta T cell proliferation (GO:0046641)2.44898348
141regulation of T cell receptor signaling pathway (GO:0050856)2.44681853
142macrophage activation (GO:0042116)2.44458207
143hepatocyte apoptotic process (GO:0097284)2.43893175
144myeloid leukocyte activation (GO:0002274)2.42965975
145positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.41819595
146cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.41747309
147regulation of mast cell activation (GO:0033003)2.41516541
148regulation of interleukin-8 secretion (GO:2000482)2.41425602
149interferon-gamma-mediated signaling pathway (GO:0060333)2.40626274
150granulocyte activation (GO:0036230)2.40589610
151G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.39611816
152production of molecular mediator involved in inflammatory response (GO:0002532)2.37855641
153nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.37347991
154regulation of T cell chemotaxis (GO:0010819)2.36488556
155positive regulation of T cell chemotaxis (GO:0010820)2.36488556
156negative regulation of viral genome replication (GO:0045071)2.35411638
157angiogenesis involved in wound healing (GO:0060055)2.34179671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.29250438
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.57622906
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.13769869
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.19872668
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.09384388
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.48787251
7SCL_19346495_ChIP-Seq_HPC-7_Human3.33942542
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.15769676
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.94730400
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.90967132
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83232096
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82905791
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82316380
14* IRF8_27001747_Chip-Seq_BMDM_Mouse2.82109519
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.67422146
16RUNX_20019798_ChIP-Seq_JUKART_Human2.66620114
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40459273
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.34201625
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32874752
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.27046389
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26951265
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25453683
23* SPI1_23547873_ChIP-Seq_NB4_Human2.24254902
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.17051366
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.15585273
26EGR1_23403033_ChIP-Seq_LIVER_Mouse2.14154347
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.08743023
28MYB_26560356_Chip-Seq_TH2_Human2.01032914
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.00346067
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.99418642
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93349308
32E2F7_22180533_ChIP-Seq_HELA_Human1.92793351
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79713889
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73963958
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73431115
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67990037
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.55448409
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51663924
39* MYB_26560356_Chip-Seq_TH1_Human1.50187715
40VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48693200
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48355752
42PU_27001747_Chip-Seq_BMDM_Mouse1.46508347
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45691719
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42956139
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41355671
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40343083
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38109932
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37633502
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36696547
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35064076
51MAF_26560356_Chip-Seq_TH1_Human1.34888000
52* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34259674
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31354216
54ZNF274_21170338_ChIP-Seq_K562_Hela1.31239349
55GATA1_22025678_ChIP-Seq_K562_Human1.30755195
56ELK1_19687146_ChIP-ChIP_HELA_Human1.29851632
57VDR_24763502_ChIP-Seq_THP-1_Human1.29373981
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.29228799
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27186730
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26837459
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26386355
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.26351198
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25365782
64* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25213428
65* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21213659
66STAT1_20625510_ChIP-Seq_HELA_Human1.16698858
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16669457
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16089706
69BCAT_22108803_ChIP-Seq_LS180_Human1.15295329
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.15129813
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13663237
72VDR_24787735_ChIP-Seq_THP-1_Human1.11993491
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11335434
74IRF1_19129219_ChIP-ChIP_H3396_Human1.10041958
75GATA3_26560356_Chip-Seq_TH2_Human1.09311512
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.08259000
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.06993301
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05248721
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04648243
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03185202
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03014548
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00991311
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99200885
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98969169
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98752543
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98134856
87SMRT_27268052_Chip-Seq_Bcells_Human0.97809536
88CIITA_25753668_ChIP-Seq_RAJI_Human0.96997185
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96812654
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.95060615
91EZH2_27294783_Chip-Seq_NPCs_Mouse0.94687263
92GATA3_27048872_Chip-Seq_THYMUS_Human0.94409471
93* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94042191
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93907775
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92474167
96PRDM14_20953172_ChIP-Seq_ESCs_Human0.92467648
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92186110
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92089487
99ER_23166858_ChIP-Seq_MCF-7_Human0.91323554
100* UTX_26944678_Chip-Seq_JUKART_Human0.91191035
101* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90881279
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90500985
103SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90209773
104GATA3_26560356_Chip-Seq_TH1_Human0.89451553
105PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89230479
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87377107
107SPI1_23127762_ChIP-Seq_K562_Human0.87098640
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85680100
109FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84613307
110* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84567843
111PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83772463
112GABP_17652178_ChIP-ChIP_JURKAT_Human0.82922746
113AR_20517297_ChIP-Seq_VCAP_Human0.82777072
114GATA3_21878914_ChIP-Seq_MCF-7_Human0.81183659
115FOXP3_21729870_ChIP-Seq_TREG_Human0.81033904
116VDR_23849224_ChIP-Seq_CD4+_Human0.80735833
117* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80539195
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.80400627
119* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79933924
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79909948
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79909948
122EST1_17652178_ChIP-ChIP_JURKAT_Human0.78392114
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78173849
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78007541
125SOX2_19829295_ChIP-Seq_ESCs_Human0.77618281
126NANOG_19829295_ChIP-Seq_ESCs_Human0.77618281
127CEBPB_22108803_ChIP-Seq_LS180_Human0.77055296
128TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.77049321
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75950196
130TCF4_22108803_ChIP-Seq_LS180_Human0.74071828
131SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.73900202
132SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.73900202
133LXR_22158963_ChIP-Seq_LIVER_Mouse0.72444537
134E2F4_17652178_ChIP-ChIP_JURKAT_Human0.71484347
135PPARA_22158963_ChIP-Seq_LIVER_Mouse0.70859069
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.70720670
137KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.70067305
138* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69018922
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.68294732
140FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.67442124
141EGR1_19032775_ChIP-ChIP_M12_Human0.62808662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.64894553
2MP0000569_abnormal_digit_pigmentation3.45503243
3MP0003724_increased_susceptibility_to3.43952086
4MP0005671_abnormal_response_to3.29352321
5MP0009785_altered_susceptibility_to2.98435544
6MP0002148_abnormal_hypersensitivity_rea2.66809178
7MP0002396_abnormal_hematopoietic_system2.45117062
8MP0003763_abnormal_thymus_physiology2.35372864
9MP0005025_abnormal_response_to2.34270731
10MP0010368_abnormal_lymphatic_system2.32496954
11MP0002419_abnormal_innate_immunity2.30738479
12MP0006082_CNS_inflammation2.30058397
13MP0001800_abnormal_humoral_immune2.26824416
14MP0001879_abnormal_lymphatic_vessel2.21918001
15MP0005000_abnormal_immune_tolerance2.21531426
16MP0003303_peritoneal_inflammation2.17958050
17MP0002452_abnormal_antigen_presenting2.15927040
18MP0000685_abnormal_immune_system2.13595324
19MP0002723_abnormal_immune_serum2.12458436
20MP0002166_altered_tumor_susceptibility2.10638818
21MP0005464_abnormal_platelet_physiology2.08243375
22MP0001819_abnormal_immune_cell2.03674931
23MP0003436_decreased_susceptibility_to2.03669547
24MP0002420_abnormal_adaptive_immunity2.03402834
25MP0001790_abnormal_immune_system2.02580311
26MP0005387_immune_system_phenotype2.02580311
27MP0005058_abnormal_lysosome_morphology1.90026851
28MP0001853_heart_inflammation1.84895927
29MP0004147_increased_porphyrin_level1.80492278
30MP0009697_abnormal_copulation1.80396069
31MP0002006_tumorigenesis1.78636917
32MP0002405_respiratory_system_inflammati1.78212130
33MP0006054_spinal_hemorrhage1.76775278
34MP0000465_gastrointestinal_hemorrhage1.76284570
35MP0009379_abnormal_foot_pigmentation1.74594640
36MP0005409_darkened_coat_color1.70030936
37MP0002398_abnormal_bone_marrow1.66482022
38MP0005075_abnormal_melanosome_morpholog1.62680435
39MP0010155_abnormal_intestine_physiology1.62286494
40MP0004808_abnormal_hematopoietic_stem1.61658552
41MP0008007_abnormal_cellular_replicative1.56909118
42MP0000716_abnormal_immune_system1.56278956
43MP0003191_abnormal_cellular_cholesterol1.54780613
44MP0000689_abnormal_spleen_morphology1.50596000
45MP0003828_pulmonary_edema1.45165620
46MP0003172_abnormal_lysosome_physiology1.43822907
47MP0009333_abnormal_splenocyte_physiolog1.42262747
48MP0005167_abnormal_blood-brain_barrier1.42024325
49MP0001873_stomach_inflammation1.40874776
50MP0003943_abnormal_hepatobiliary_system1.40147789
51MP0002009_preneoplasia1.40039733
52MP0002722_abnormal_immune_system1.38410818
53MP0002132_abnormal_respiratory_system1.37675963
54MP0009764_decreased_sensitivity_to1.36497424
55MP0001845_abnormal_inflammatory_respons1.36362312
56MP0003866_abnormal_defecation1.34783448
57MP0002429_abnormal_blood_cell1.32720379
58MP0005397_hematopoietic_system_phenotyp1.31613821
59MP0001545_abnormal_hematopoietic_system1.31613821
60MP0000343_altered_response_to1.28837035
61MP0003075_altered_response_to1.28760125
62MP0008469_abnormal_protein_level1.26466448
63MP0006292_abnormal_olfactory_placode1.24046154
64MP0004381_abnormal_hair_follicle1.22994193
65MP0001851_eye_inflammation1.22686930
66MP0002933_joint_inflammation1.22470852
67MP0000015_abnormal_ear_pigmentation1.21225421
68MP0003279_aneurysm1.20116996
69MP0002277_abnormal_respiratory_mucosa1.19643921
70MP0005174_abnormal_tail_pigmentation1.18042438
71MP0003195_calcinosis1.17993171
72MP0003690_abnormal_glial_cell1.17185396
73MP0000604_amyloidosis1.16968085
74MP0001533_abnormal_skeleton_physiology1.16732130
75MP0005084_abnormal_gallbladder_morpholo1.15941576
76MP0000858_altered_metastatic_potential1.14390035
77MP0009278_abnormal_bone_marrow1.13830407
78MP0002638_abnormal_pupillary_reflex1.12404399
79MP0000703_abnormal_thymus_morphology1.09999414
80MP0000767_abnormal_smooth_muscle1.06756048
81MP0005171_absent_coat_pigmentation1.03498468
82MP0003186_abnormal_redox_activity1.02836198
83MP0002095_abnormal_skin_pigmentation1.02246741
84MP0009763_increased_sensitivity_to0.99533924
85MP0004947_skin_inflammation0.99147446
86MP0008058_abnormal_DNA_repair0.97854731
87MP0000249_abnormal_blood_vessel0.97783680
88MP0000372_irregular_coat_pigmentation0.97731206
89MP0003252_abnormal_bile_duct0.95033434
90MP0000490_abnormal_crypts_of0.94384723
91MP0005365_abnormal_bile_salt0.94109999
92MP0002254_reproductive_system_inflammat0.89215178
93MP0003300_gastrointestinal_ulcer0.88817923
94MP0003448_altered_tumor_morphology0.87593321
95MP0004782_abnormal_surfactant_physiolog0.84018130
96MP0004084_abnormal_cardiac_muscle0.83028933
97MP0010329_abnormal_lipoprotein_level0.82551614
98MP0005670_abnormal_white_adipose0.81288518
99MP0004130_abnormal_muscle_cell0.80138710
100MP0008875_abnormal_xenobiotic_pharmacok0.78569695
101MP0002998_abnormal_bone_remodeling0.76648195
102MP0002098_abnormal_vibrissa_morphology0.75600858
103MP0005220_abnormal_exocrine_pancreas0.74683795
104MP0001188_hyperpigmentation0.73850090
105MP0004883_abnormal_blood_vessel0.70789736
106MP0008057_abnormal_DNA_replication0.70369095
107MP0005390_skeleton_phenotype0.70037231
108MP0002138_abnormal_hepatobiliary_system0.69857652
109MP0005085_abnormal_gallbladder_physiolo0.69793036
110MP0000613_abnormal_salivary_gland0.69768726
111MP0008775_abnormal_heart_ventricle0.69252126
112MP0005164_abnormal_response_to0.69075796
113MP0003806_abnormal_nucleotide_metabolis0.68835075
114MP0009643_abnormal_urine_homeostasis0.68141533
115MP0001986_abnormal_taste_sensitivity0.67679923
116MP0003941_abnormal_skin_development0.67647739
117MP0005166_decreased_susceptibility_to0.67646037
118MP0009765_abnormal_xenobiotic_induced0.67475707
119MP0001764_abnormal_homeostasis0.65825455
120MP0005408_hypopigmentation0.65344783
121MP0001191_abnormal_skin_condition0.64851097
122MP0006072_abnormal_retinal_apoptosis0.64377530
123MP0003795_abnormal_bone_structure0.63375818
124MP0000516_abnormal_urinary_system0.62708168
125MP0005367_renal/urinary_system_phenotyp0.62708168
126MP0005595_abnormal_vascular_smooth0.62353808
127MP0005310_abnormal_salivary_gland0.61958970
128MP0002928_abnormal_bile_duct0.61929350
129MP0000371_diluted_coat_color0.61665962
130MP0001915_intracranial_hemorrhage0.61386483
131MP0000920_abnormal_myelination0.61111094
132MP0001663_abnormal_digestive_system0.60655307
133MP0005360_urolithiasis0.60617561

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.31360888
2Spontaneous hematomas (HP:0007420)4.12232502
3Abnormal delayed hypersensitivity skin test (HP:0002963)3.97280050
4Myositis (HP:0100614)3.96416627
5Elevated erythrocyte sedimentation rate (HP:0003565)3.79325421
6Recurrent bacterial skin infections (HP:0005406)3.77232612
7Chronic diarrhea (HP:0002028)3.32123493
8Eczematoid dermatitis (HP:0000976)3.24148198
9Orchitis (HP:0100796)3.22493613
10Retrobulbar optic neuritis (HP:0100654)3.21455088
11Optic neuritis (HP:0100653)3.21455088
12Severe combined immunodeficiency (HP:0004430)3.19025348
13Abnormality of glycolipid metabolism (HP:0010969)3.12290863
14Abnormality of liposaccharide metabolism (HP:0010968)3.12290863
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.12290863
16Prolonged bleeding time (HP:0003010)3.11548362
17Thrombocytosis (HP:0001894)3.09105616
18Recurrent skin infections (HP:0001581)3.08580288
19Abnormality of the prostate (HP:0008775)3.07601981
20Thyroiditis (HP:0100646)3.05241547
21Systemic lupus erythematosus (HP:0002725)3.00854702
22T lymphocytopenia (HP:0005403)2.99441701
23Reduced antithrombin III activity (HP:0001976)2.98588414
24Abnormality of T cell number (HP:0011839)2.95951252
25Recurrent fungal infections (HP:0002841)2.93956041
26Glomerulonephritis (HP:0000099)2.84907815
27Hypoplasia of the thymus (HP:0000778)2.84879505
28Panhypogammaglobulinemia (HP:0003139)2.82205905
29Chronic mucocutaneous candidiasis (HP:0002728)2.80089423
30Recurrent cutaneous fungal infections (HP:0011370)2.80089423
31Recurrent viral infections (HP:0004429)2.78257699
32Vacuolated lymphocytes (HP:0001922)2.77469546
33Epistaxis (HP:0000421)2.72568340
34Combined immunodeficiency (HP:0005387)2.72501884
35IgM deficiency (HP:0002850)2.72260645
36Prostate neoplasm (HP:0100787)2.69411319
37Increased cerebral lipofuscin (HP:0011813)2.62286769
38Abnormality of the pleura (HP:0002103)2.60263828
39Congenital stationary night blindness (HP:0007642)2.58179729
40Gastrointestinal infarctions (HP:0005244)2.57176308
41Meningitis (HP:0001287)2.56625014
42Petechiae (HP:0000967)2.56457420
43Reticulocytopenia (HP:0001896)2.56422429
44Abnormality of eosinophils (HP:0001879)2.55133880
45Hemoptysis (HP:0002105)2.49586721
46Abnormality of T cells (HP:0002843)2.48791266
47Mutism (HP:0002300)2.48715976
48Leukocytosis (HP:0001974)2.47664972
49IgG deficiency (HP:0004315)2.46607747
50Eosinophilia (HP:0001880)2.45789746
51Abnormality of B cell number (HP:0010975)2.41102661
52B lymphocytopenia (HP:0010976)2.41102661
53Pulmonary fibrosis (HP:0002206)2.40304091
54Recurrent gram-negative bacterial infections (HP:0005420)2.39877525
55Mediastinal lymphadenopathy (HP:0100721)2.37733368
56Pustule (HP:0200039)2.35498275
57Renal cortical cysts (HP:0000803)2.34627290
583-Methylglutaconic aciduria (HP:0003535)2.34248173
59Joint hemorrhage (HP:0005261)2.34199325
60Agammaglobulinemia (HP:0004432)2.34127248
61Chronic obstructive pulmonary disease (HP:0006510)2.33292953
62Obstructive lung disease (HP:0006536)2.33292953
63Chest pain (HP:0100749)2.32632894
64Abnormality of macrophages (HP:0004311)2.31839572
65Hematochezia (HP:0002573)2.29886973
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.28600041
67Delayed CNS myelination (HP:0002188)2.27769636
68Keratoconjunctivitis sicca (HP:0001097)2.26476092
69Stomatitis (HP:0010280)2.26122415
70Encephalitis (HP:0002383)2.25486985
71Vasculitis (HP:0002633)2.25404204
72Type 2 muscle fiber atrophy (HP:0003554)2.24964719
73Granulocytopenia (HP:0001913)2.23941135
74Abnormality of the renal collecting system (HP:0004742)2.21540028
75Colitis (HP:0002583)2.20755145
76Type I transferrin isoform profile (HP:0003642)2.20038244
77Pulmonary infiltrates (HP:0002113)2.19553622
78Chromsome breakage (HP:0040012)2.18442657
79Microcytic anemia (HP:0001935)2.16062930
80Purpura (HP:0000979)2.14840075
81Gangrene (HP:0100758)2.14341672
82Hypoproteinemia (HP:0003075)2.13783515
83Gingival bleeding (HP:0000225)2.13711870
84Mesangial abnormality (HP:0001966)2.12055855
85Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11668960
86Chronic otitis media (HP:0000389)2.11506353
87Ulnar claw (HP:0001178)2.09089490
88Patchy hypopigmentation of hair (HP:0011365)2.08349646
89Autoimmune thrombocytopenia (HP:0001973)2.07928402
90Hepatosplenomegaly (HP:0001433)2.07867108
91Autoimmune hemolytic anemia (HP:0001890)2.05892485
92Dysostosis multiplex (HP:0000943)2.05669402
93Complement deficiency (HP:0004431)2.04625547
94Agnosia (HP:0010524)2.03784690
95Periodontitis (HP:0000704)2.03135868
96Keratoconjunctivitis (HP:0001096)2.03037650
97Abnormality of DNA repair (HP:0003254)2.02840377
98Increased IgM level (HP:0003496)2.02649026
99Pulmonary embolism (HP:0002204)2.01507788
100Abnormality of the peritoneum (HP:0002585)2.01281878
101Polyneuropathy (HP:0001271)2.00948875
102Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98168451
103Abnormality of T cell physiology (HP:0011840)1.97760779
104Increased IgE level (HP:0003212)1.96766125
105Acute myeloid leukemia (HP:0004808)1.95387105
106Nephritis (HP:0000123)1.95177884
107Impaired platelet aggregation (HP:0003540)1.95059131
108Abnormal platelet function (HP:0011869)1.95059131
109Loss of speech (HP:0002371)1.93405743
110Abnormal drinking behavior (HP:0030082)1.93373103
111Polydipsia (HP:0001959)1.93373103
112Abnormality of male internal genitalia (HP:0000022)1.92228611
113Lymphoma (HP:0002665)1.91507225
114Recurrent pneumonia (HP:0006532)1.91165449
115Portal hypertension (HP:0001409)1.91024780
116Urticaria (HP:0001025)1.90092522
117Scanning speech (HP:0002168)1.89716636
118Basal ganglia calcification (HP:0002135)1.89499481
119Disinhibition (HP:0000734)1.89403188
120White forelock (HP:0002211)1.89386815
121Muscle fiber atrophy (HP:0100295)1.89309800
122Nonimmune hydrops fetalis (HP:0001790)1.88193597
123Arterial thrombosis (HP:0004420)1.88011501
124Abnormality of transition element cation homeostasis (HP:0011030)1.87519726
125Hypergammaglobulinemia (HP:0010702)1.86625861
126Ectropion (HP:0000656)1.86111604
127Hypothermia (HP:0002045)1.86035131
128Prolonged partial thromboplastin time (HP:0003645)1.85368515
129Menorrhagia (HP:0000132)1.84526046
130Stomach cancer (HP:0012126)1.83909927
131Lymphopenia (HP:0001888)1.83838633
132Papilloma (HP:0012740)1.82705116
133Verrucae (HP:0200043)1.82705116
134Thrombophlebitis (HP:0004418)1.82052585
135Abnormality of small intestinal villus morphology (HP:0011472)1.81785156
136Villous atrophy (HP:0011473)1.81785156
137Abnormal biliary tract physiology (HP:0012439)1.80407135
138Bile duct proliferation (HP:0001408)1.80407135
139Abnormal spermatogenesis (HP:0008669)1.79689176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.40601553
2TXK3.76543335
3FRK3.72966161
4TGFBR23.14788674
5KDR3.11922224
6MAP4K13.04098358
7TIE12.94597301
8KIT2.58210113
9MAP3K142.52723173
10CAMKK22.44065299
11TGFBR12.40777330
12IRAK42.28567265
13TEC2.15898900
14IKBKE2.15115090
15MAPKAPK32.11415675
16TYK21.97040838
17TBK11.86122781
18IRAK31.86095967
19JAK31.84162512
20PLK21.82087817
21BLK1.79962746
22NUAK11.74980234
23ZAP701.68711002
24CDK81.64763635
25IKBKB1.60466437
26NEK91.58088410
27BMPR1B1.53433362
28NLK1.51335912
29FLT31.45044955
30BTK1.41393682
31CAMK1D1.40718348
32ADRBK21.36010333
33ITK1.34781958
34ZAK1.32137797
35MAP2K31.29412814
36YES11.24513215
37CLK11.23491163
38GRK11.21792113
39CSF1R1.21133037
40NME21.19307181
41VRK11.18344343
42LCK1.17421497
43MUSK1.13287317
44MAP2K61.13254096
45GRK61.12833048
46STK161.09926142
47NEK61.09466064
48EIF2AK21.08268272
49TAOK21.07047815
50LYN1.06989745
51CDK91.04759052
52FGFR41.04337756
53CSK1.04274214
54SIK31.02790000
55INSRR1.02312073
56FGFR21.00929354
57TNIK0.98623950
58SYK0.92837004
59BRD40.91915493
60MAPK70.91898636
61TYRO30.91070579
62JAK10.90480152
63GRK70.90280712
64STK100.87383607
65MKNK10.86685317
66MST40.86247517
67MAP3K120.85977564
68WNK40.85099904
69BMPR20.84657795
70CHUK0.82689564
71SRPK10.79536163
72MAP3K130.77750307
73PIM10.77264955
74HCK0.75123415
75FGR0.72277639
76AKT30.70443125
77OXSR10.69812152
78MYLK0.69785173
79CAMKK10.69042248
80FGFR30.68011753
81MET0.67670571
82STK40.67321110
83IRAK10.66222237
84PDK10.65268383
85CDK60.64663866
86MAPK150.61814433
87PRKG20.61101476
88PIM20.60695479
89PIK3CG0.60458944
90MKNK20.60079405
91CAMK1G0.58641613
92PDK20.58557042
93IGF1R0.55802407
94DAPK20.53690853
95PTK2B0.52928866
96PRKAA20.52764337
97CDK30.52441442
98MAPK120.51183057
99ERBB30.50956403
100EGFR0.50541385
101ADRBK10.47388624
102RPS6KA40.47286539
103FES0.47150128
104BRSK20.44953615
105TAOK30.44408967
106MARK30.44278816
107RPS6KA50.43865742
108ERBB20.43011001
109TLK10.42948282
110MAP3K30.42925492
111EIF2AK30.42356015
112PIK3CA0.42337436
113CAMK40.41506401
114MAPK110.41494054
115ABL10.40754535
116TNK20.40704753
117MATK0.40457946
118CDK70.40414708
119FER0.40348033
120JAK20.39597852
121ATR0.38641373
122TRPM70.37987101
123MAPKAPK50.37588375
124LRRK20.34798685
125PRKCQ0.34341781
126MAPK40.34064360
127PRKCD0.33178422
128PRKCI0.33021948
129ACVR1B0.32625052
130RPS6KB20.32039853
131CSNK1G10.30592695
132FYN0.30427668
133BCKDK0.30340461
134MAPK30.29836523
135WNK10.27593923
136MAPKAPK20.26496884
137MAP4K20.24599143
138PRKCE0.23427301

Predicted pathways (KEGG)

RankGene SetZ-score
1Type I diabetes mellitus_Homo sapiens_hsa049403.17491037
2Primary immunodeficiency_Homo sapiens_hsa053402.91875987
3Staphylococcus aureus infection_Homo sapiens_hsa051502.66887906
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.54949318
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.50382962
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.07566402
7Graft-versus-host disease_Homo sapiens_hsa053322.07492701
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.07360111
9Measles_Homo sapiens_hsa051622.05609968
10Hematopoietic cell lineage_Homo sapiens_hsa046401.99074359
11Leishmaniasis_Homo sapiens_hsa051401.88348832
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78435285
13Antigen processing and presentation_Homo sapiens_hsa046121.76618726
14Malaria_Homo sapiens_hsa051441.73655422
15Ribosome_Homo sapiens_hsa030101.67181306
16Allograft rejection_Homo sapiens_hsa053301.63576122
17Other glycan degradation_Homo sapiens_hsa005111.58604698
18Protein export_Homo sapiens_hsa030601.57894806
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57681252
20Non-homologous end-joining_Homo sapiens_hsa034501.57592241
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.56314571
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.55718239
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55026908
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54176498
25Complement and coagulation cascades_Homo sapiens_hsa046101.53195257
26Herpes simplex infection_Homo sapiens_hsa051681.48992647
27Nitrogen metabolism_Homo sapiens_hsa009101.35578632
28Pertussis_Homo sapiens_hsa051331.35428615
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30134921
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28563391
31Osteoclast differentiation_Homo sapiens_hsa043801.27224603
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.26609428
33Phagosome_Homo sapiens_hsa041451.25833453
34DNA replication_Homo sapiens_hsa030301.21841818
35Legionellosis_Homo sapiens_hsa051341.20434138
36Caffeine metabolism_Homo sapiens_hsa002321.19548630
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17939009
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17901129
39Asthma_Homo sapiens_hsa053101.16666668
40Homologous recombination_Homo sapiens_hsa034401.15527513
41Mismatch repair_Homo sapiens_hsa034301.15461798
42Autoimmune thyroid disease_Homo sapiens_hsa053201.14444666
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10180603
44Influenza A_Homo sapiens_hsa051641.10036191
45Chemical carcinogenesis_Homo sapiens_hsa052041.09052977
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08583624
47Folate biosynthesis_Homo sapiens_hsa007901.08125465
48B cell receptor signaling pathway_Homo sapiens_hsa046621.04111450
49Fanconi anemia pathway_Homo sapiens_hsa034601.03135308
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02488408
51T cell receptor signaling pathway_Homo sapiens_hsa046601.02300691
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.01858418
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01223403
54Base excision repair_Homo sapiens_hsa034101.00139305
55RNA polymerase_Homo sapiens_hsa030200.99784401
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99618317
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.99528070
58Retinol metabolism_Homo sapiens_hsa008300.96028164
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.95529702
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.94201428
61Toxoplasmosis_Homo sapiens_hsa051450.92522186
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88687126
63Fatty acid elongation_Homo sapiens_hsa000620.86253125
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86038348
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85301179
66TNF signaling pathway_Homo sapiens_hsa046680.83970125
67Pyrimidine metabolism_Homo sapiens_hsa002400.83536023
68Nucleotide excision repair_Homo sapiens_hsa034200.83511755
69Hepatitis B_Homo sapiens_hsa051610.82523222
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82163599
71ABC transporters_Homo sapiens_hsa020100.81829817
72Lysosome_Homo sapiens_hsa041420.80716697
73Arachidonic acid metabolism_Homo sapiens_hsa005900.79579840
74Peroxisome_Homo sapiens_hsa041460.79173270
75African trypanosomiasis_Homo sapiens_hsa051430.79139433
76Rheumatoid arthritis_Homo sapiens_hsa053230.78963400
77Apoptosis_Homo sapiens_hsa042100.78246332
78Shigellosis_Homo sapiens_hsa051310.77673763
79RNA degradation_Homo sapiens_hsa030180.76594224
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74402690
81Platelet activation_Homo sapiens_hsa046110.73932813
82Vitamin digestion and absorption_Homo sapiens_hsa049770.73394389
83Hepatitis C_Homo sapiens_hsa051600.72914124
84Notch signaling pathway_Homo sapiens_hsa043300.72308223
85Viral myocarditis_Homo sapiens_hsa054160.70315427
86Sphingolipid metabolism_Homo sapiens_hsa006000.70125954
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69274491
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67794315
89Chemokine signaling pathway_Homo sapiens_hsa040620.66339893
90Basal transcription factors_Homo sapiens_hsa030220.65214680
91Linoleic acid metabolism_Homo sapiens_hsa005910.63372573
92Ether lipid metabolism_Homo sapiens_hsa005650.61931933
93Histidine metabolism_Homo sapiens_hsa003400.61318747
94Tuberculosis_Homo sapiens_hsa051520.60472477
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.60380904
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60125256
97Salmonella infection_Homo sapiens_hsa051320.58526553
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58168054
99Glutathione metabolism_Homo sapiens_hsa004800.57404604
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55777133
101Phototransduction_Homo sapiens_hsa047440.54925329
102Steroid biosynthesis_Homo sapiens_hsa001000.52306410
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49559404
104p53 signaling pathway_Homo sapiens_hsa041150.48960144
105Spliceosome_Homo sapiens_hsa030400.48743622
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47818507
107HTLV-I infection_Homo sapiens_hsa051660.43917472
108Epstein-Barr virus infection_Homo sapiens_hsa051690.43477864
109Systemic lupus erythematosus_Homo sapiens_hsa053220.42572724
110Type II diabetes mellitus_Homo sapiens_hsa049300.41881765
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41822278
112One carbon pool by folate_Homo sapiens_hsa006700.40896376
113Purine metabolism_Homo sapiens_hsa002300.39916468
114Glycerolipid metabolism_Homo sapiens_hsa005610.37344012
115Small cell lung cancer_Homo sapiens_hsa052220.37259813
116Dorso-ventral axis formation_Homo sapiens_hsa043200.35663184
117Acute myeloid leukemia_Homo sapiens_hsa052210.35283283
118Collecting duct acid secretion_Homo sapiens_hsa049660.34992675
119Regulation of autophagy_Homo sapiens_hsa041400.34168755
120Tryptophan metabolism_Homo sapiens_hsa003800.33339415
121Prolactin signaling pathway_Homo sapiens_hsa049170.32515858
122PPAR signaling pathway_Homo sapiens_hsa033200.27753877
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27452892
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23552625
125mTOR signaling pathway_Homo sapiens_hsa041500.21038238
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.19365285
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.18384750
128Renin-angiotensin system_Homo sapiens_hsa046140.18197660
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18197099
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17657899
131* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17606595
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.16720266
133HIF-1 signaling pathway_Homo sapiens_hsa040660.14224988
134Renin secretion_Homo sapiens_hsa049240.13110440
135Insulin resistance_Homo sapiens_hsa049310.11595368
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.10445366
137Viral carcinogenesis_Homo sapiens_hsa052030.09403625
138Mineral absorption_Homo sapiens_hsa049780.08784368

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