LPCAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* chemical homeostasis within a tissue (GO:0048875)9.75699973
2pattern specification involved in kidney development (GO:0061004)6.99665981
3cellular response to nitric oxide (GO:0071732)5.69563461
4positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003605.15805529
5dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.11568321
6morphogenesis of an endothelium (GO:0003159)4.57471094
7endothelial tube morphogenesis (GO:0061154)4.57471094
8response to xenobiotic stimulus (GO:0009410)4.49525105
9positive regulation of endothelial cell differentiation (GO:0045603)4.47871111
10response to nitric oxide (GO:0071731)4.38277965
11epithelial tube branching involved in lung morphogenesis (GO:0060441)4.29904187
12positive regulation by symbiont of host defense response (GO:0052509)4.17269732
13modulation by symbiont of host defense response (GO:0052031)4.17269732
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.17269732
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.17269732
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.17269732
17modulation by symbiont of host immune response (GO:0052553)4.17269732
18lung lobe morphogenesis (GO:0060463)4.11001567
19cellular response to reactive nitrogen species (GO:1902170)3.95952239
20regulation of endothelial cell differentiation (GO:0045601)3.84255682
21respiratory gaseous exchange (GO:0007585)3.81586060
22mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.65897867
23regulation of hippo signaling (GO:0035330)3.59614286
24negative regulation of interleukin-2 production (GO:0032703)3.52395837
25DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.49993592
26mesodermal cell differentiation (GO:0048333)3.44826050
27establishment of apical/basal cell polarity (GO:0035089)3.41203836
28macrophage chemotaxis (GO:0048246)3.37901166
29regulation of interferon-beta biosynthetic process (GO:0045357)3.33972571
30adherens junction assembly (GO:0034333)3.31404813
31DNA damage response, signal transduction resulting in transcription (GO:0042772)3.31210558
32adenine nucleotide transport (GO:0051503)3.31135644
33segment specification (GO:0007379)3.27988693
34cellular anion homeostasis (GO:0030002)3.26471841
35respiratory tube development (GO:0030323)3.23309163
36macrophage activation involved in immune response (GO:0002281)3.23117345
37negative regulation of type 2 immune response (GO:0002829)3.21700964
38response to peptidoglycan (GO:0032494)3.18401529
39response to laminar fluid shear stress (GO:0034616)3.16530913
40lung-associated mesenchyme development (GO:0060484)3.14443099
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.14369578
423-UTR-mediated mRNA stabilization (GO:0070935)3.13287889
43negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.12428596
44positive regulation of Cdc42 GTPase activity (GO:0043089)3.10990292
45embryonic foregut morphogenesis (GO:0048617)3.10783236
46sodium-independent organic anion transport (GO:0043252)3.09289267
47negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.07242410
48establishment of monopolar cell polarity (GO:0061162)3.05671646
49establishment or maintenance of monopolar cell polarity (GO:0061339)3.05671646
50lateral sprouting from an epithelium (GO:0060601)3.04303018
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.01093679
52regulation of vasculogenesis (GO:2001212)2.97486049
53cell-substrate adherens junction assembly (GO:0007045)2.97148602
54focal adhesion assembly (GO:0048041)2.97148602
55epithelial cell differentiation involved in prostate gland development (GO:0060742)2.96856859
56axis elongation (GO:0003401)2.95892328
57RNA stabilization (GO:0043489)2.95823555
58mRNA stabilization (GO:0048255)2.95823555
59trivalent inorganic anion homeostasis (GO:0072506)2.95463165
60phosphate ion homeostasis (GO:0055062)2.95463165
61purine ribonucleotide transport (GO:0015868)2.93577259
62antigen processing and presentation of endogenous antigen (GO:0019883)2.91649850
63response to muramyl dipeptide (GO:0032495)2.90362409
64regulation of glomerular filtration (GO:0003093)2.89266338
65branch elongation of an epithelium (GO:0060602)2.89002290
66glial cell proliferation (GO:0014009)2.85620275
67embryonic process involved in female pregnancy (GO:0060136)2.84669877
68forebrain neuron differentiation (GO:0021879)2.83315138
69glomerular epithelial cell development (GO:0072310)2.82118538
70negative regulation of transcription by competitive promoter binding (GO:0010944)2.80874691
71regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.80779384
72regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76025195
73blood vessel maturation (GO:0001955)2.74051805
74activation of Rac GTPase activity (GO:0032863)2.72990279
75Leydig cell differentiation (GO:0033327)2.71022937
76positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70967553
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.70320980
78negative regulation of cell killing (GO:0031342)2.70320980
79eye photoreceptor cell differentiation (GO:0001754)2.68378327
80photoreceptor cell differentiation (GO:0046530)2.68378327
81pituitary gland development (GO:0021983)2.68349198
82lung secretory cell differentiation (GO:0061140)2.67462426
83proximal/distal pattern formation (GO:0009954)2.66886928
84nuclear pore complex assembly (GO:0051292)2.66714816
85semaphorin-plexin signaling pathway (GO:0071526)2.66398438
86regulation of NFAT protein import into nucleus (GO:0051532)2.65753046
87Golgi transport vesicle coating (GO:0048200)2.65525069
88COPI coating of Golgi vesicle (GO:0048205)2.65525069
89modulation by symbiont of host cellular process (GO:0044068)2.64919960
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.64379700
91protein retention in ER lumen (GO:0006621)2.63841630
92folic acid transport (GO:0015884)2.63309425
93negative regulation of toll-like receptor signaling pathway (GO:0034122)2.63212356
94response to host (GO:0075136)2.62478372
95response to host defenses (GO:0052200)2.62478372
96response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.62478372
97negative regulation of erythrocyte differentiation (GO:0045647)2.58524817
98regulation of interleukin-13 production (GO:0032656)2.58246259
99stress fiber assembly (GO:0043149)2.57928844
100planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56904535
101cerebral cortex neuron differentiation (GO:0021895)2.56677816
102positive regulation of chemokine secretion (GO:0090197)2.56576333
103positive thymic T cell selection (GO:0045059)2.56004312
104response to host immune response (GO:0052572)2.55916077
105response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55916077
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.54740326
107postsynaptic membrane organization (GO:0001941)2.52134178
108positive regulation of gamma-delta T cell activation (GO:0046645)2.52073367
109glomerular visceral epithelial cell development (GO:0072015)2.51053067
110maternal placenta development (GO:0001893)2.50909306
111positive regulation of interferon-alpha production (GO:0032727)2.50550354
112NIK/NF-kappaB signaling (GO:0038061)2.50319791
113apoptotic process involved in morphogenesis (GO:0060561)2.50230164
114branching involved in labyrinthine layer morphogenesis (GO:0060670)2.50210407
115one-carbon compound transport (GO:0019755)2.49921229
116detection of other organism (GO:0098543)2.49323747
117polarized epithelial cell differentiation (GO:0030859)2.48629098
118developmental induction (GO:0031128)2.47973940
119mesenchymal cell proliferation (GO:0010463)2.47213218
120negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.46269458
121pentose-phosphate shunt (GO:0006098)2.46197070
122protein complex localization (GO:0031503)2.46112157
123regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.45761427
124cellular response to virus (GO:0098586)2.45340402
125endocardial cushion development (GO:0003197)2.45307305
126pinocytosis (GO:0006907)2.45298282
127purine nucleotide transport (GO:0015865)2.44339157
128pre-miRNA processing (GO:0031054)2.43851341
129histone H3-K36 demethylation (GO:0070544)2.43295656
130regulation of smooth muscle cell differentiation (GO:0051150)2.42984129
131detection of bacterium (GO:0016045)2.41996652
132positive regulation of keratinocyte differentiation (GO:0045618)2.41875475
133sphingosine metabolic process (GO:0006670)2.41788453
134regulation of glucose import in response to insulin stimulus (GO:2001273)2.41282452
135cell-cell signaling involved in cell fate commitment (GO:0045168)2.40975095
136lipopolysaccharide-mediated signaling pathway (GO:0031663)2.40786184
137regulation of early endosome to late endosome transport (GO:2000641)2.40599906
138establishment or maintenance of apical/basal cell polarity (GO:0035088)2.39412454
139establishment or maintenance of bipolar cell polarity (GO:0061245)2.39412454
140lung alveolus development (GO:0048286)2.39053274
141phosphate ion transmembrane transport (GO:0035435)2.38652165
142regulation of chemokine secretion (GO:0090196)2.38501944
143folic acid metabolic process (GO:0046655)2.38141838
144cellular protein complex localization (GO:0034629)2.37177438
145endothelial cell differentiation (GO:0045446)2.37022955
146mannose metabolic process (GO:0006013)2.36973431
147trophectodermal cell differentiation (GO:0001829)2.36626876
148establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.36578415
149regulation of glial cell proliferation (GO:0060251)2.36034422
150regulation of gamma-delta T cell activation (GO:0046643)2.35877430
151negative regulation of fatty acid transport (GO:2000192)2.35445935
152virion attachment to host cell (GO:0019062)2.34812828
153adhesion of symbiont to host cell (GO:0044650)2.34812828
154cellular hyperosmotic response (GO:0071474)2.34607207
155hippo signaling (GO:0035329)2.34367661
156cell-substrate junction assembly (GO:0007044)2.33824758
157regulation of interferon-alpha production (GO:0032647)2.33242051
158cranial suture morphogenesis (GO:0060363)2.32809000
159regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.32281402
160gas transport (GO:0015669)2.32249826
161vascular endothelial growth factor signaling pathway (GO:0038084)2.31577898
162positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.31189083
163protein localization to endosome (GO:0036010)2.30984389
164heterochromatin organization (GO:0070828)2.30792101
165sodium ion homeostasis (GO:0055078)2.29948460
166regulation of response to osmotic stress (GO:0047484)2.29914045
167DNA unwinding involved in DNA replication (GO:0006268)2.28573439
168regulation of mammary gland epithelial cell proliferation (GO:0033599)2.28231216
169regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.28056674
170negative regulation of cell fate specification (GO:0009996)2.26765389
171lymphangiogenesis (GO:0001946)2.26729830
172regulation of type 2 immune response (GO:0002828)2.25585235
173response to vitamin A (GO:0033189)2.25073669
174thymic T cell selection (GO:0045061)2.24856176
175determination of adult lifespan (GO:0008340)2.23102401
176detection of molecule of bacterial origin (GO:0032490)2.21980081
177negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.21729285
178regulation of leukocyte degranulation (GO:0043300)2.21411939
179germinal center formation (GO:0002467)2.20641490
180response to interleukin-6 (GO:0070741)2.20428994
181activation of MAPKKK activity (GO:0000185)2.20408474
182regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.19778832
183renal system process involved in regulation of blood volume (GO:0001977)2.18994780
184L-alpha-amino acid transmembrane transport (GO:1902475)2.18721346
185regulation of SMAD protein import into nucleus (GO:0060390)2.18449152
186negative regulation of interleukin-12 production (GO:0032695)2.18387594
187negative regulation of T cell proliferation (GO:0042130)2.18163684
188cytoskeletal anchoring at plasma membrane (GO:0007016)2.18123553
189negative regulation of telomerase activity (GO:0051974)2.17370775
190regulation of interleukin-2 biosynthetic process (GO:0045076)2.17043503
191mesenchymal to epithelial transition (GO:0060231)2.16636734
192* surfactant homeostasis (GO:0043129)12.6981070

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.43624654
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.69123933
3GATA1_22025678_ChIP-Seq_K562_Human3.41264221
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.35319416
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.34494270
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.30020397
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.91708342
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.76191813
9ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.72848270
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.68265559
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.51732263
12LXR_22292898_ChIP-Seq_THP-1_Human2.29892785
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.25411229
14TCF3_18692474_ChIP-Seq_MEFs_Mouse2.16724166
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.16396757
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.15997451
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.15225312
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.09079900
19KDM2B_26808549_Chip-Seq_K562_Human2.03949330
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98633980
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86400597
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81127268
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.78946438
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.75531738
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75188488
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73964898
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71039987
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70873484
29TCF3_18692474_ChIP-Seq_MESCs_Mouse1.68593952
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68120012
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65548746
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.62390225
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62322724
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59043047
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58296137
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57712451
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57642076
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57049402
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56959306
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56911762
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56911762
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56911762
43NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.55855329
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54709146
45AHR_22903824_ChIP-Seq_MCF-7_Human1.54565711
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53226133
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52587561
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52520924
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.46724819
50KDM2B_26808549_Chip-Seq_DND41_Human1.46661264
51MYC_22102868_ChIP-Seq_BL_Human1.46323571
52* VDR_21846776_ChIP-Seq_THP-1_Human1.46294630
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46177130
54NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45554443
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45248458
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.44791404
57* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43809118
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43151230
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.43067244
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42080485
61* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40718891
62ZNF263_19887448_ChIP-Seq_K562_Human1.40634229
63* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40477640
64* RUNX1_22412390_ChIP-Seq_EML_Mouse1.40263313
65UTX_26944678_Chip-Seq_JUKART_Human1.39219671
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.38887481
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38371074
68ISL1_27105846_Chip-Seq_CPCs_Mouse1.35753240
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.34987700
70VDR_24763502_ChIP-Seq_THP-1_Human1.34876345
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34229234
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33980552
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33871405
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33209923
75TCF7_22412390_ChIP-Seq_EML_Mouse1.32075501
76SCL_19346495_ChIP-Seq_HPC-7_Human1.31426935
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30879924
78SPI1_23127762_ChIP-Seq_K562_Human1.30006135
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29648956
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29409360
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.28530333
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27976162
83RACK7_27058665_Chip-Seq_MCF-7_Human1.27708308
84MAF_26560356_Chip-Seq_TH2_Human1.27364123
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27153324
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26734808
87* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22974575
88EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22209958
89CLOCK_20551151_ChIP-Seq_293T_Human1.22141445
90TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.21881732
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21694897
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20667548
93ATF3_27146783_Chip-Seq_COLON_Human1.19657171
94GATA1_19941826_ChIP-Seq_K562_Human1.19446070
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19442929
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18856704
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18058953
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18005060
99* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17025486
100* SMC4_20622854_ChIP-Seq_HELA_Human1.14438749
101PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.13600587
102* RUNX1_27514584_Chip-Seq_MCF-7_Human1.12819443
103FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11530496
104FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10151982
105UBF1/2_26484160_Chip-Seq_HMECs_Human1.10025369
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09028333
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08545067
108E2F1_21310950_ChIP-Seq_MCF-7_Human1.08537308
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07260766
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07149875
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06282712
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.05820373
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.05499633
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05311880
115SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04907455
116KLF5_25053715_ChIP-Seq_YYC3_Human1.03597258
117* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02754868
118GATA2_21666600_ChIP-Seq_HMVEC_Human1.02344039
119POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01825845
120STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01805558
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01770892
122CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01250034
123* IRF8_27001747_Chip-Seq_BMDM_Mouse1.00899062
124ARNT_22903824_ChIP-Seq_MCF-7_Human1.00565935
125TET1_21451524_ChIP-Seq_MESCs_Mouse1.00540332
126NCOR1_26117541_ChIP-Seq_K562_Human1.00456058
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00339673
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00171811
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99275569
130* P68_20966046_ChIP-Seq_HELA_Human0.99063718
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98570296
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98542496
133FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97744105
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.97061172
135CREB1_26743006_Chip-Seq_LNCaP_Human0.97017689
136SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96966072
137* GATA1_19941827_ChIP-Seq_MEL_Mouse0.95489225
138SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95013326
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94610330
140KAP1_27257070_Chip-Seq_ESCs_Mouse0.94437507
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94368431
142CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93882847
143RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93592002
144CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93344335
145EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92175068
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91198496
147KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89964619
148CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89379303
149ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89299910
150NANOG_21062744_ChIP-ChIP_HESCs_Human0.88796894
151MAF_26560356_Chip-Seq_TH1_Human0.88488999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004782_abnormal_surfactant_physiolog7.58721532
2MP0001958_emphysema5.18782063
3MP0008995_early_reproductive_senescence4.91155101
4MP0008004_abnormal_stomach_pH3.83826515
5MP0003705_abnormal_hypodermis_morpholog3.77534935
6MP0010368_abnormal_lymphatic_system2.85839825
7MP0000566_synostosis2.58893196
8MP0000537_abnormal_urethra_morphology2.41090520
9MP0003436_decreased_susceptibility_to2.33980461
10MP0005083_abnormal_biliary_tract2.33888956
11MP0009278_abnormal_bone_marrow2.33096705
12MP0003300_gastrointestinal_ulcer2.12161525
13* MP0005388_respiratory_system_phenotype2.11213703
14* MP0002133_abnormal_respiratory_system2.11213703
15MP0001879_abnormal_lymphatic_vessel2.11145124
16MP0003453_abnormal_keratinocyte_physiol2.07667429
17MP0002254_reproductive_system_inflammat2.00472809
18MP0005451_abnormal_body_composition1.90428411
19MP0003890_abnormal_embryonic-extraembry1.81225199
20MP0000858_altered_metastatic_potential1.79369233
21* MP0001177_atelectasis1.78372570
22MP0003786_premature_aging1.73170106
23MP0004947_skin_inflammation1.72534980
24MP0002138_abnormal_hepatobiliary_system1.70110223
25MP0003724_increased_susceptibility_to1.64950865
26MP0003115_abnormal_respiratory_system1.60024761
27MP0005167_abnormal_blood-brain_barrier1.57416880
28MP0010030_abnormal_orbit_morphology1.57017972
29MP0001835_abnormal_antigen_presentation1.56383267
30MP0004264_abnormal_extraembryonic_tissu1.56287631
31MP0003119_abnormal_digestive_system1.51578278
32MP0004272_abnormal_basement_membrane1.50397859
33MP0002419_abnormal_innate_immunity1.49630433
34MP0002277_abnormal_respiratory_mucosa1.41879402
35MP0005000_abnormal_immune_tolerance1.41139269
36MP0005025_abnormal_response_to1.40807043
37MP0004233_abnormal_muscle_weight1.40139228
38* MP0001175_abnormal_lung_morphology1.39296496
39MP0005253_abnormal_eye_physiology1.37979651
40MP0000534_abnormal_ureter_morphology1.37662404
41MP0003763_abnormal_thymus_physiology1.37405467
42MP0002998_abnormal_bone_remodeling1.36593020
43MP0003183_abnormal_peptide_metabolism1.34175593
44MP0003950_abnormal_plasma_membrane1.33072070
45MP0002089_abnormal_postnatal_growth/wei1.29383584
46MP0002796_impaired_skin_barrier1.28999919
47MP0004808_abnormal_hematopoietic_stem1.28176781
48MP0009333_abnormal_splenocyte_physiolog1.27985803
49MP0001800_abnormal_humoral_immune1.27104378
50MP0002452_abnormal_antigen_presenting1.26382772
51* MP0005551_abnormal_eye_electrophysiolog1.24891454
52MP0002723_abnormal_immune_serum1.24867152
53MP0009672_abnormal_birth_weight1.24324386
54MP0005076_abnormal_cell_differentiation1.21420181
55MP0001819_abnormal_immune_cell1.20761132
56MP0002420_abnormal_adaptive_immunity1.20756440
57MP0006072_abnormal_retinal_apoptosis1.19081072
58MP0003111_abnormal_nucleus_morphology1.14454331
59MP0005621_abnormal_cell_physiology1.12937116
60MP0002398_abnormal_bone_marrow1.12044486
61MP0003172_abnormal_lysosome_physiology1.11118742
62MP0001348_abnormal_lacrimal_gland1.10414528
63MP0003303_peritoneal_inflammation1.10183340
64MP0003942_abnormal_urinary_system1.09684147
65MP0004858_abnormal_nervous_system1.09546473
66* MP0002295_abnormal_pulmonary_circulatio1.08177340
67MP0005257_abnormal_intraocular_pressure1.07095099
68MP0002166_altered_tumor_susceptibility1.06608758
69MP0001533_abnormal_skeleton_physiology1.05717885
70MP0002396_abnormal_hematopoietic_system1.05400518
71MP0001873_stomach_inflammation1.05381099
72MP0009840_abnormal_foam_cell1.04318722
73MP0001346_abnormal_lacrimal_gland1.04120946
74MP0000703_abnormal_thymus_morphology1.03953687
75MP0000716_abnormal_immune_system1.03180456
76MP0000516_abnormal_urinary_system1.02308699
77MP0005367_renal/urinary_system_phenotyp1.02308699
78MP0002405_respiratory_system_inflammati1.01433911
79MP0005623_abnormal_meninges_morphology1.00509787
80* MP0005195_abnormal_posterior_eye0.99563040
81MP0005671_abnormal_response_to0.99280635
82MP0010155_abnormal_intestine_physiology0.99164272
83MP0002282_abnormal_trachea_morphology0.99049306
84MP0002234_abnormal_pharynx_morphology0.98371119
85MP0003690_abnormal_glial_cell0.97973730
86MP0000767_abnormal_smooth_muscle0.97259123
87MP0010307_abnormal_tumor_latency0.97009445
88MP0010352_gastrointestinal_tract_polyps0.96742890
89MP0002925_abnormal_cardiovascular_devel0.96537644
90* MP0001943_abnormal_respiration0.96356884
91MP0000631_abnormal_neuroendocrine_gland0.94962925
92MP0002429_abnormal_blood_cell0.94855514
93MP0003984_embryonic_growth_retardation0.93823612
94MP0002722_abnormal_immune_system0.93643587
95MP0005391_vision/eye_phenotype0.92776175
96MP0001672_abnormal_embryogenesis/_devel0.92134171
97MP0005380_embryogenesis_phenotype0.92134171
98MP0001730_embryonic_growth_arrest0.91844383
99MP0003011_delayed_dark_adaptation0.91551489
100MP0004510_myositis0.91331148
101MP0006292_abnormal_olfactory_placode0.90596849
102MP0008260_abnormal_autophagy0.90521963
103MP0005409_darkened_coat_color0.90418333
104MP0000465_gastrointestinal_hemorrhage0.90290265
105MP0002098_abnormal_vibrissa_morphology0.89399800
106MP0002088_abnormal_embryonic_growth/wei0.88519040
107MP0002332_abnormal_exercise_endurance0.87676475
108MP0001915_intracranial_hemorrhage0.87660885
109MP0006082_CNS_inflammation0.87105780
110MP0010234_abnormal_vibrissa_follicle0.85252133
111MP0002148_abnormal_hypersensitivity_rea0.85085634
112MP0004957_abnormal_blastocyst_morpholog0.84435193
113MP0002006_tumorigenesis0.84369753
114MP0002132_abnormal_respiratory_system0.84111052
115MP0001849_ear_inflammation0.83236066
116MP0003566_abnormal_cell_adhesion0.83164456
117MP0005397_hematopoietic_system_phenotyp0.83077560
118MP0001545_abnormal_hematopoietic_system0.83077560
119MP0003075_altered_response_to0.82362821
120MP0000685_abnormal_immune_system0.82206481
121MP0001293_anophthalmia0.82201249
122MP0004883_abnormal_blood_vessel0.81867169
123MP0002697_abnormal_eye_size0.81564770
124MP0003091_abnormal_cell_migration0.81368075
125MP0002085_abnormal_embryonic_tissue0.80379467
126MP0005501_abnormal_skin_physiology0.80175363
127MP0000678_abnormal_parathyroid_gland0.80087294
128MP0003191_abnormal_cellular_cholesterol0.79846811
129MP0001853_heart_inflammation0.79811726
130MP0000350_abnormal_cell_proliferation0.76844156
131MP0001851_eye_inflammation0.75405364
132MP0002084_abnormal_developmental_patter0.73645552
133MP0002653_abnormal_ependyma_morphology0.72940182
134MP0000462_abnormal_digestive_system0.72770020
135MP0003937_abnormal_limbs/digits/tail_de0.72753840
136MP0010678_abnormal_skin_adnexa0.72721735
137MP0001286_abnormal_eye_development0.71873443
138MP0003935_abnormal_craniofacial_develop0.70379156
139MP0003448_altered_tumor_morphology0.68195683
140MP0002086_abnormal_extraembryonic_tissu0.66673830
141MP0003693_abnormal_embryo_hatching0.65428611
142MP0004185_abnormal_adipocyte_glucose0.64679802
143MP0000428_abnormal_craniofacial_morphol0.63559923
144MP0000681_abnormal_thyroid_gland0.63526833
145MP0003077_abnormal_cell_cycle0.62649084
146MP0000383_abnormal_hair_follicle0.62639735
147* MP0001614_abnormal_blood_vessel0.62362681
148MP0002233_abnormal_nose_morphology0.61956675
149MP0000490_abnormal_crypts_of0.60594114
150MP0003943_abnormal_hepatobiliary_system0.59889177
151MP0008789_abnormal_olfactory_epithelium0.59061989
152MP0003123_paternal_imprinting0.58365427
153MP0005058_abnormal_lysosome_morphology0.58309414
154MP0002877_abnormal_melanocyte_morpholog0.57689891
155MP0000778_abnormal_nervous_system0.57256723
156MP0005023_abnormal_wound_healing0.57147753
157MP0006054_spinal_hemorrhage0.56039309
158MP0004197_abnormal_fetal_growth/weight/0.55526161
159MP0000627_abnormal_mammary_gland0.55263478
160MP0005595_abnormal_vascular_smooth0.54839530
161MP0005187_abnormal_penis_morphology0.54594584
162MP0005387_immune_system_phenotype0.52418016
163MP0001790_abnormal_immune_system0.52418016
164MP0005394_taste/olfaction_phenotype0.52219167

Predicted human phenotypes

RankGene SetZ-score
1Tachypnea (HP:0002789)4.93245858
2Tubulointerstitial fibrosis (HP:0005576)4.93075380
3Respiratory distress (HP:0002098)3.96658909
4Hyperactive renin-angiotensin system (HP:0000841)3.84201032
5Chronic bronchitis (HP:0004469)3.77321901
6Renal salt wasting (HP:0000127)3.76260170
7Hyperacusis (HP:0010780)3.60387009
8Eczematoid dermatitis (HP:0000976)3.36469351
9Abnormality of the fingertips (HP:0001211)3.29089153
10Onycholysis (HP:0001806)3.28378886
11Tubulointerstitial nephritis (HP:0001970)3.15706758
12Polycythemia (HP:0001901)3.10800216
13Thyroid-stimulating hormone excess (HP:0002925)3.08812205
14Ulnar bowing (HP:0003031)3.04493305
15Neurofibrillary tangles (HP:0002185)3.04312379
16Hematochezia (HP:0002573)3.02745211
17Tubulointerstitial abnormality (HP:0001969)2.89700443
18Congenital stationary night blindness (HP:0007642)2.78670362
19Stenosis of the external auditory canal (HP:0000402)2.76286184
20Megalencephaly (HP:0001355)2.65388938
21Supranuclear gaze palsy (HP:0000605)2.63558798
22Bony spicule pigmentary retinopathy (HP:0007737)2.60085431
23Recurrent abscess formation (HP:0002722)2.57178485
24Asymmetry of the thorax (HP:0001555)2.54344232
25Chronic otitis media (HP:0000389)2.53091085
26Cerebral inclusion bodies (HP:0100314)2.51475370
27Abnormality of the fetal cardiovascular system (HP:0010948)2.45381029
28Abnormal umbilical cord blood vessels (HP:0011403)2.45381029
29Single umbilical artery (HP:0001195)2.45381029
30Cellulitis (HP:0100658)2.39658721
31Stomach cancer (HP:0012126)2.35743444
32Tubular atrophy (HP:0000092)2.28929257
33Segmental peripheral demyelination/remyelination (HP:0003481)2.28735752
34Pendular nystagmus (HP:0012043)2.23338763
35Gout (HP:0001997)2.22754723
36Bowed forearm bones (HP:0003956)2.20873889
37Bowing of the arm (HP:0006488)2.20873889
38Hyperkalemia (HP:0002153)2.20245339
39Gastrointestinal stroma tumor (HP:0100723)2.20217483
40Posterior subcapsular cataract (HP:0007787)2.18324295
41Insomnia (HP:0100785)2.13375974
42Disproportionate tall stature (HP:0001519)2.11908069
43Broad distal phalanx of finger (HP:0009836)2.11698905
44Split foot (HP:0001839)2.11361739
45Abnormal rod and cone electroretinograms (HP:0008323)2.11116035
46Neonatal respiratory distress (HP:0002643)2.10807110
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10052101
48Arnold-Chiari malformation (HP:0002308)2.09359708
49Broad face (HP:0000283)2.08644271
50Partial duplication of thumb phalanx (HP:0009944)2.07582362
51Visceral angiomatosis (HP:0100761)2.07011792
52Recurrent bacterial skin infections (HP:0005406)2.04878095
53Hypotension (HP:0002615)2.03577205
54Elfin facies (HP:0004428)2.02135827
55Hemangiomatosis (HP:0007461)2.01560859
56Increased cerebral lipofuscin (HP:0011813)2.01344296
57Vertebral compression fractures (HP:0002953)2.00821045
58Interstitial pulmonary disease (HP:0006530)12.4072007
59Syringomyelia (HP:0003396)1.99056105
60Spinal cord lesions (HP:0100561)1.99056105
61Renal hypoplasia (HP:0000089)1.98795088
62Abnormality of the distal phalanx of the thumb (HP:0009617)1.98756440
63Colitis (HP:0002583)1.96982826
64Cerebral aneurysm (HP:0004944)1.94110294
65Chorioretinal atrophy (HP:0000533)1.92811738
66Long palpebral fissure (HP:0000637)1.92557568
67Shallow orbits (HP:0000586)1.92332334
68Partial duplication of the phalanx of hand (HP:0009999)1.91831832
69Esophageal atresia (HP:0002032)1.89467915
70Overriding aorta (HP:0002623)1.88887065
71Selective tooth agenesis (HP:0001592)1.88060878
72Abnormality of the nasal mucosa (HP:0000433)1.87893430
73Protrusio acetabuli (HP:0003179)1.87659888
74Recurrent gram-negative bacterial infections (HP:0005420)1.87498568
75Polygenic inheritance (HP:0010982)1.87056440
76Bronchitis (HP:0012387)1.86103031
77Abnormality of the labia minora (HP:0012880)1.85891513
78Shawl scrotum (HP:0000049)1.85286940
79Abnormality of liposaccharide metabolism (HP:0010968)1.85202673
80Abnormality of glycosphingolipid metabolism (HP:0004343)1.85202673
81Abnormality of glycolipid metabolism (HP:0010969)1.85202673
82Fragile nails (HP:0001808)1.84756500
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84552010
84Metaphyseal cupping (HP:0003021)1.84369201
85Micronodular cirrhosis (HP:0001413)1.84054712
86Abnormality of the thoracic spine (HP:0100711)1.83301185
87Hemorrhage of the eye (HP:0011885)1.82120732
88Midline defect of the nose (HP:0004122)1.81948637
89Hyponatremia (HP:0002902)1.81391039
90Bronchomalacia (HP:0002780)1.80398055
91Broad metatarsal (HP:0001783)1.79236370
92Renal duplication (HP:0000075)1.78415349
93Turricephaly (HP:0000262)1.78377265
94Spontaneous hematomas (HP:0007420)1.77653302
95Osteolytic defects of the hand bones (HP:0009699)1.77369618
96Osteolytic defects of the phalanges of the hand (HP:0009771)1.77369618
97Persistence of primary teeth (HP:0006335)1.77270620
98Thin bony cortex (HP:0002753)1.76579221
99Renovascular hypertension (HP:0100817)1.75893917
100Increased IgE level (HP:0003212)1.75338444
101Flat acetabular roof (HP:0003180)1.75030256
102Intestinal atresia (HP:0011100)1.74141217
103Anteriorly placed anus (HP:0001545)1.73463224
104Gingivitis (HP:0000230)1.72467680
105Neuronal loss in central nervous system (HP:0002529)1.72441280
106Subacute progressive viral hepatitis (HP:0006572)1.71167830
107Emphysema (HP:0002097)1.70965857
108Thickened helices (HP:0000391)1.70705203
109Mediastinal lymphadenopathy (HP:0100721)1.69783162
110Pigmentary retinal degeneration (HP:0001146)1.68667688
111Orchitis (HP:0100796)1.68385743
112Long toe (HP:0010511)1.67552629
113Aqueductal stenosis (HP:0002410)1.66773976
114Gastrointestinal atresia (HP:0002589)1.65945292
115Gastrointestinal infarctions (HP:0005244)1.65812963
116Progressive sensorineural hearing impairment (HP:0000408)1.65785040
117Ankyloglossia (HP:0010296)1.65626724
118Distal lower limb amyotrophy (HP:0008944)1.65566963
119Subcapsular cataract (HP:0000523)1.64725302
120Viral hepatitis (HP:0006562)1.64602605
121Increased neuronal autofluorescent lipopigment (HP:0002074)1.64333178
122Achilles tendon contracture (HP:0001771)1.64109495
123Humeroradial synostosis (HP:0003041)1.62188853
124Synostosis involving the elbow (HP:0003938)1.62188853
125Patellar dislocation (HP:0002999)1.62055013
126Supernumerary nipples (HP:0002558)1.61317097
127Abnormality of oral frenula (HP:0000190)1.60491909
128Rapidly progressive (HP:0003678)1.60200340
129Gastrointestinal inflammation (HP:0004386)1.60123962
130Pathologic fracture (HP:0002756)1.59159530
131Restrictive lung disease (HP:0002091)1.58598206
132Meningitis (HP:0001287)1.58212277
133Abnormality of chloride homeostasis (HP:0011422)1.57424077
134Increased connective tissue (HP:0009025)1.57106309
135Microcytic anemia (HP:0001935)1.56775603
136Personality changes (HP:0000751)1.56659331
137Colon cancer (HP:0003003)1.56255196
138Germ cell neoplasia (HP:0100728)1.56089364
139Abnormality of cells of the lymphoid lineage (HP:0012140)1.55663887
140Dysmetric saccades (HP:0000641)1.55643241
141Thoracic kyphosis (HP:0002942)1.55265402
142Long nose (HP:0003189)1.55166217
143Hyperaldosteronism (HP:0000859)1.55068189
144Deep venous thrombosis (HP:0002625)1.54875379
145Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.54642146
146Loss of speech (HP:0002371)1.54323535
147Pointed chin (HP:0000307)1.54265498
148Myocardial infarction (HP:0001658)1.53887841
149Arterial tortuosity (HP:0005116)1.53856723
150Cortical dysplasia (HP:0002539)1.53705002
151Myositis (HP:0100614)1.53303615
152Leiomyosarcoma (HP:0100243)1.52513625
153Uterine leiomyosarcoma (HP:0002891)1.52513625
154Abnormality of macrophages (HP:0004311)1.52447706
155Skull defect (HP:0001362)1.52426761
156Gastrointestinal carcinoma (HP:0002672)1.51808465
157Malignant gastrointestinal tract tumors (HP:0006749)1.51808465
158Bone pain (HP:0002653)1.51738910
159Premature rupture of membranes (HP:0001788)1.50976397
160Premature skin wrinkling (HP:0100678)1.50666357
161Esophageal varix (HP:0002040)1.49412456
162Pulmonary hypertension (HP:0002092)1.49364419
163Dysostosis multiplex (HP:0000943)1.49303979
164Abnormality of sodium homeostasis (HP:0010931)1.49121030
165Distal lower limb muscle weakness (HP:0009053)1.48975303
166Rectal prolapse (HP:0002035)1.48681273
167Osteomyelitis (HP:0002754)1.48061028
168Slow saccadic eye movements (HP:0000514)1.47785856
169Lymphopenia (HP:0001888)1.47768348
170Abnormality of the 2nd finger (HP:0004100)1.47727905
171Abolished electroretinogram (ERG) (HP:0000550)1.45945768
172Pulmonary artery stenosis (HP:0004415)1.45690348
173Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.44507314
174Milia (HP:0001056)1.43765278
175Transitional cell carcinoma of the bladder (HP:0006740)1.41648210
176Aplasia involving bones of the extremities (HP:0009825)1.40280531
177Aplasia involving bones of the upper limbs (HP:0009823)1.40280531
178Aplasia of the phalanges of the hand (HP:0009802)1.40280531
179Hypoplasia of the ulna (HP:0003022)1.39796328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK245.25484000
2FGFR24.23820708
3SMG13.68974089
4TIE13.67461766
5LRRK23.56404406
6TGFBR23.47209133
7PRPF4B3.11130303
8ERN12.71717950
9IRAK32.71108435
10STK102.64109808
11GRK12.62608318
12PAK42.57246265
13FGFR42.48829709
14MAPK152.48596201
15EEF2K2.44663040
16ZAP702.43396156
17EPHB22.16344734
18SIK12.15820469
19RIPK42.10358098
20ILK2.05014411
21MAP3K91.96010527
22PDGFRB1.76191672
23IRAK41.75731291
24EPHA21.74800029
25CDK61.60747564
26MAP3K141.59267603
27TRIB31.51002620
28PKN21.50501258
29TTN1.50192766
30EPHB11.48123270
31MAP3K131.45632434
32TGFBR11.45031266
33MST1R1.32935524
34FGR1.30425721
35CLK11.25653441
36TAOK21.20173884
37LMTK21.19318077
38CAMK1D1.12736654
39RPS6KA41.12637779
40CDC42BPA1.10239675
41MTOR1.08243563
42RIPK11.06785402
43MAP2K31.06182942
44TAOK11.05749025
45GSK3A1.04308807
46TYK21.04225218
47MAP3K101.03652966
48CDK41.03383363
49TBK11.01779760
50RPS6KA21.00457981
51NME20.99847735
52DAPK20.99405829
53IRAK20.97579441
54BLK0.96372837
55CDK120.96011127
56HIPK20.93110346
57KSR20.92494175
58SIK30.90653197
59MST40.90359138
60TYRO30.89929493
61PDPK10.89827997
62YES10.88621923
63MAP3K80.87755745
64PDGFRA0.87549321
65AURKA0.87381383
66MELK0.84173026
67CSF1R0.83208207
68CHUK0.82730190
69VRK10.82304117
70BMX0.82031128
71MAP3K30.81768387
72EGFR0.81573264
73PTK60.80029165
74MAP3K10.78021158
75KDR0.76999493
76PRKD20.75817772
77JAK30.75753694
78RPS6KL10.72879853
79RPS6KC10.72879853
80MATK0.71769092
81DYRK1B0.71194465
82MAP2K20.70063867
83MKNK20.69489355
84DYRK20.69270018
85ERBB20.68559440
86NTRK10.67753423
87JAK10.67342122
88FER0.66926474
89MARK20.65599549
90TESK20.65582395
91MAP4K10.65103403
92MOS0.64923084
93BTK0.64894011
94CSK0.64152636
95DYRK30.63307365
96CAMK1G0.61352361
97MET0.61243326
98CHEK20.60755440
99NEK60.60402548
100EPHA30.60204080
101SCYL20.59303130
102ICK0.58847723
103CDC70.58611840
104FGFR10.57585105
105ARAF0.57288828
106IKBKE0.54369833
107HCK0.54318009
108CASK0.54205636
109MKNK10.53994563
110BRD40.53286281
111RPS6KA10.52932492
112IRAK10.52521182
113NEK20.51004113
114PDK10.50794631
115MAPK110.50623497
116FGFR30.49819167
117MARK10.49030732
118NEK90.48691348
119CDK80.48635825
120CSNK1G30.48227838
121RPS6KA60.47756908
122RET0.46913513
123LATS10.46525585
124CSNK1G10.45589539
125STK30.44574874
126PRKD10.44266940
127NLK0.43806247
128MAP3K110.43514238
129MAP3K20.41643556
130CSNK1G20.40710231
131RPS6KB20.40257108
132SGK30.38968226
133STK40.37924510
134TTK0.37242248
135SRPK10.36805438
136GRK60.34925565
137DYRK1A0.34683577
138CSNK1A1L0.33640611
139ACVR1B0.33502315
140PLK10.33395553
141ADRBK10.33274672
142MAPK130.33021474
143SIK20.32928356
144JAK20.32536593
145BRAF0.32285653
146ABL10.32250570
147PRKG20.31942235
148ERBB30.31749315
149LATS20.31480196
150PRKCI0.31232347
151CDK70.30758404
152ALK0.29759535
153PTK20.29349468
154PIM10.29296127
155RPS6KA50.29256434
156GRK50.29138461
157CDK90.28251493

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.73438635
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.02125314
3Adherens junction_Homo sapiens_hsa045201.79225455
4Hippo signaling pathway_Homo sapiens_hsa043901.68697500
5Mineral absorption_Homo sapiens_hsa049781.65414889
6Osteoclast differentiation_Homo sapiens_hsa043801.62947189
7Central carbon metabolism in cancer_Homo sapiens_hsa052301.56055097
8Leishmaniasis_Homo sapiens_hsa051401.54714202
9Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.53287069
10Other glycan degradation_Homo sapiens_hsa005111.52405384
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47428749
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45742384
13Colorectal cancer_Homo sapiens_hsa052101.42578496
14Small cell lung cancer_Homo sapiens_hsa052221.41499840
15ECM-receptor interaction_Homo sapiens_hsa045121.40662536
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.35571052
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32041132
18Endometrial cancer_Homo sapiens_hsa052131.31066073
19Tight junction_Homo sapiens_hsa045301.31059452
20Influenza A_Homo sapiens_hsa051641.30333835
21Thyroid cancer_Homo sapiens_hsa052161.30237757
22Renal cell carcinoma_Homo sapiens_hsa052111.29278772
23Bladder cancer_Homo sapiens_hsa052191.27861237
24MicroRNAs in cancer_Homo sapiens_hsa052061.22485972
25Chronic myeloid leukemia_Homo sapiens_hsa052201.21560874
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.20984261
27Lysosome_Homo sapiens_hsa041421.19460459
28Hepatitis B_Homo sapiens_hsa051611.19333131
29Measles_Homo sapiens_hsa051621.18680722
30Basal cell carcinoma_Homo sapiens_hsa052171.17282295
31Pancreatic cancer_Homo sapiens_hsa052121.16202926
32Axon guidance_Homo sapiens_hsa043601.14423333
33Notch signaling pathway_Homo sapiens_hsa043301.13553860
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12330823
35Herpes simplex infection_Homo sapiens_hsa051681.11430503
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09494169
37Cell cycle_Homo sapiens_hsa041101.08496423
38Prion diseases_Homo sapiens_hsa050201.08244464
39Staphylococcus aureus infection_Homo sapiens_hsa051501.08118778
40TGF-beta signaling pathway_Homo sapiens_hsa043501.06227273
41TNF signaling pathway_Homo sapiens_hsa046681.05732103
42Pathways in cancer_Homo sapiens_hsa052001.04352774
43DNA replication_Homo sapiens_hsa030301.03383216
44Focal adhesion_Homo sapiens_hsa045101.03187571
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01583940
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01571850
47VEGF signaling pathway_Homo sapiens_hsa043701.00409532
48Tuberculosis_Homo sapiens_hsa051521.00229574
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99217289
50B cell receptor signaling pathway_Homo sapiens_hsa046620.98512811
51Graft-versus-host disease_Homo sapiens_hsa053320.97969886
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97604151
53Rap1 signaling pathway_Homo sapiens_hsa040150.97190172
54Allograft rejection_Homo sapiens_hsa053300.96197034
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94881663
56Pentose phosphate pathway_Homo sapiens_hsa000300.94618715
57T cell receptor signaling pathway_Homo sapiens_hsa046600.93833683
58Ribosome_Homo sapiens_hsa030100.92898592
59Base excision repair_Homo sapiens_hsa034100.91864431
60Viral myocarditis_Homo sapiens_hsa054160.91655369
61HIF-1 signaling pathway_Homo sapiens_hsa040660.91450808
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89181727
63Phagosome_Homo sapiens_hsa041450.88335293
64Malaria_Homo sapiens_hsa051440.86965719
65Spliceosome_Homo sapiens_hsa030400.86955627
66Dorso-ventral axis formation_Homo sapiens_hsa043200.86860437
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86763780
68Apoptosis_Homo sapiens_hsa042100.86684471
69Autoimmune thyroid disease_Homo sapiens_hsa053200.86504982
70Hedgehog signaling pathway_Homo sapiens_hsa043400.86210774
71Proteoglycans in cancer_Homo sapiens_hsa052050.86100827
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.85657373
73HTLV-I infection_Homo sapiens_hsa051660.84458357
74Toxoplasmosis_Homo sapiens_hsa051450.84265759
75Wnt signaling pathway_Homo sapiens_hsa043100.84232030
76Prostate cancer_Homo sapiens_hsa052150.84097367
77Fatty acid biosynthesis_Homo sapiens_hsa000610.83977244
78Mismatch repair_Homo sapiens_hsa034300.82436543
79Salmonella infection_Homo sapiens_hsa051320.79052515
80Non-small cell lung cancer_Homo sapiens_hsa052230.78584631
81Alcoholism_Homo sapiens_hsa050340.78320660
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76961398
83Insulin signaling pathway_Homo sapiens_hsa049100.76685848
84Legionellosis_Homo sapiens_hsa051340.76463038
85Acute myeloid leukemia_Homo sapiens_hsa052210.76385993
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.76371540
87Endocytosis_Homo sapiens_hsa041440.76104606
88Galactose metabolism_Homo sapiens_hsa000520.75777533
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75699744
90Glioma_Homo sapiens_hsa052140.75664906
91Platelet activation_Homo sapiens_hsa046110.75008835
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74871287
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74432036
94Viral carcinogenesis_Homo sapiens_hsa052030.73999479
95Melanoma_Homo sapiens_hsa052180.73982016
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73981635
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.73493878
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.71345921
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71102409
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71097807
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70999207
102Epstein-Barr virus infection_Homo sapiens_hsa051690.70174036
103Shigellosis_Homo sapiens_hsa051310.69771888
104Gap junction_Homo sapiens_hsa045400.69348452
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66919549
106ErbB signaling pathway_Homo sapiens_hsa040120.66723352
107Melanogenesis_Homo sapiens_hsa049160.66492602
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65890249
109Olfactory transduction_Homo sapiens_hsa047400.65879261
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65746024
111Primary immunodeficiency_Homo sapiens_hsa053400.65658510
112Chemokine signaling pathway_Homo sapiens_hsa040620.65567115
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.64952297
114Systemic lupus erythematosus_Homo sapiens_hsa053220.64670445
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64571862
116Estrogen signaling pathway_Homo sapiens_hsa049150.63049493
117GnRH signaling pathway_Homo sapiens_hsa049120.62777187
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.62319066
119Ras signaling pathway_Homo sapiens_hsa040140.62262828
120Inositol phosphate metabolism_Homo sapiens_hsa005620.61519823
121Fructose and mannose metabolism_Homo sapiens_hsa000510.61417675
122p53 signaling pathway_Homo sapiens_hsa041150.61371899
123MAPK signaling pathway_Homo sapiens_hsa040100.60692742
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60507132
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60346668
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60259472
127Hematopoietic cell lineage_Homo sapiens_hsa046400.59875941
128Choline metabolism in cancer_Homo sapiens_hsa052310.59172316
129Prolactin signaling pathway_Homo sapiens_hsa049170.58453498
130Pertussis_Homo sapiens_hsa051330.58328047
131Antigen processing and presentation_Homo sapiens_hsa046120.58102450
132Amoebiasis_Homo sapiens_hsa051460.57294141
133Insulin resistance_Homo sapiens_hsa049310.57221050
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56877142
135Gastric acid secretion_Homo sapiens_hsa049710.56590497
136Oocyte meiosis_Homo sapiens_hsa041140.56536377
137mTOR signaling pathway_Homo sapiens_hsa041500.55555896
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55540067
139mRNA surveillance pathway_Homo sapiens_hsa030150.55343304
140AMPK signaling pathway_Homo sapiens_hsa041520.55307022
141FoxO signaling pathway_Homo sapiens_hsa040680.54717951
142Hepatitis C_Homo sapiens_hsa051600.54596121
143RNA transport_Homo sapiens_hsa030130.53941178
144Taste transduction_Homo sapiens_hsa047420.53196208

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