LPCAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.86386805
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.86386805
3modulation by symbiont of host immune response (GO:0052553)6.86386805
4positive regulation by symbiont of host defense response (GO:0052509)6.86386805
5modulation by symbiont of host defense response (GO:0052031)6.86386805
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.86386805
7microglial cell activation (GO:0001774)6.80894802
8positive regulation of chemokine secretion (GO:0090197)5.99027794
9macrophage activation involved in immune response (GO:0002281)5.93271277
10regulation of interferon-beta biosynthetic process (GO:0045357)5.78318084
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.66250620
12G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.15631114
13detection of molecule of bacterial origin (GO:0032490)5.08069677
14response to peptidoglycan (GO:0032494)4.84876676
15neutrophil activation involved in immune response (GO:0002283)4.78595616
16regulation of chemokine secretion (GO:0090196)4.68201450
17response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.67402358
18response to host immune response (GO:0052572)4.67402358
19macrophage activation (GO:0042116)4.45632461
20respiratory burst (GO:0045730)4.45601273
21cellular extravasation (GO:0045123)4.44411483
22response to host (GO:0075136)4.39009153
23response to host defenses (GO:0052200)4.39009153
24response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.39009153
25hemidesmosome assembly (GO:0031581)4.38290584
26detection of other organism (GO:0098543)4.37631615
27positive regulation of interferon-alpha production (GO:0032727)4.34522442
28detection of external biotic stimulus (GO:0098581)4.29909005
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.26503953
30positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.24369406
31regulation of B cell receptor signaling pathway (GO:0050855)4.11454397
32negative regulation of granulocyte differentiation (GO:0030853)4.10960839
33regulation of interferon-alpha production (GO:0032647)4.09350758
34immunoglobulin mediated immune response (GO:0016064)4.08509690
35positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.03493705
36response to muramyl dipeptide (GO:0032495)3.99740934
37positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.94960497
38myeloid cell activation involved in immune response (GO:0002275)3.93773703
39detection of bacterium (GO:0016045)3.83027196
40positive regulation of antigen processing and presentation (GO:0002579)3.78961505
41detection of biotic stimulus (GO:0009595)3.75942365
42purinergic nucleotide receptor signaling pathway (GO:0035590)3.73030331
43neutrophil activation (GO:0042119)3.68160625
44G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.67248844
45granulocyte activation (GO:0036230)3.65607183
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.61212517
47negative regulation of cell killing (GO:0031342)3.61212517
48antigen processing and presentation of endogenous antigen (GO:0019883)3.55636605
49I-kappaB phosphorylation (GO:0007252)3.53067791
50positive regulation of B cell differentiation (GO:0045579)3.50130520
51positive regulation of cellular amide metabolic process (GO:0034250)3.46951573
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.44899893
53negative regulation of interleukin-12 production (GO:0032695)3.40524079
54negative regulation of interleukin-6 production (GO:0032715)3.39933249
55regulation of mast cell degranulation (GO:0043304)3.38794223
56lipopolysaccharide-mediated signaling pathway (GO:0031663)3.37905959
57regulation of gamma-delta T cell activation (GO:0046643)3.35408446
58macrophage differentiation (GO:0030225)3.33829931
59regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.33421294
60positive regulation of mast cell activation involved in immune response (GO:0033008)3.31789117
61positive regulation of mast cell degranulation (GO:0043306)3.31789117
62regulation of antigen processing and presentation (GO:0002577)3.25788057
63positive regulation of mast cell activation (GO:0033005)3.25120147
64regulation of mast cell activation involved in immune response (GO:0033006)3.24475048
65hypotonic response (GO:0006971)3.21330283
66regulation of interferon-gamma biosynthetic process (GO:0045072)3.20099850
67production of molecular mediator involved in inflammatory response (GO:0002532)3.13545278
68hydrogen peroxide biosynthetic process (GO:0050665)3.13343172
69regulation of macrophage cytokine production (GO:0010935)3.11970354
70regulation of mast cell activation (GO:0033003)3.11474349
71positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.11228518
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.11086530
73purinergic receptor signaling pathway (GO:0035587)3.10751724
74negative regulation of erythrocyte differentiation (GO:0045647)3.09692410
75neutrophil mediated immunity (GO:0002446)3.07942065
76negative regulation of interleukin-17 production (GO:0032700)3.07230774
77positive regulation of toll-like receptor signaling pathway (GO:0034123)3.07028206
78oligosaccharide catabolic process (GO:0009313)3.06166806
79hyaluronan catabolic process (GO:0030214)3.05466897
80glycosphingolipid catabolic process (GO:0046479)3.05303303
81neutrophil chemotaxis (GO:0030593)3.04807305
82myeloid leukocyte mediated immunity (GO:0002444)3.03577531
83superoxide anion generation (GO:0042554)3.02485634
84myeloid leukocyte activation (GO:0002274)3.01325017
85negative regulation of T cell mediated immunity (GO:0002710)3.01173108
86keratan sulfate catabolic process (GO:0042340)3.00481956
87regulation of gamma-delta T cell differentiation (GO:0045586)3.00398147
88adaptation of signaling pathway (GO:0023058)3.00274209
89regulation of interleukin-8 biosynthetic process (GO:0045414)2.98535753
90positive regulation of interferon-beta production (GO:0032728)2.97660858
91leukocyte degranulation (GO:0043299)2.96864270
92tolerance induction (GO:0002507)2.96345078
93leukocyte aggregation (GO:0070486)2.95969853
94neutrophil migration (GO:1990266)2.95429633
95negative regulation of lymphocyte mediated immunity (GO:0002707)2.93991748
96regulation of regulated secretory pathway (GO:1903305)2.93842039
97positive regulation of chemokine production (GO:0032722)2.92379041
98positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.91213135
99positive regulation of gamma-delta T cell activation (GO:0046645)2.91080178
100regulation of B cell differentiation (GO:0045577)2.90231593
101regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.88562221
102regulation of leukocyte degranulation (GO:0043300)2.85099997
103T-helper 1 type immune response (GO:0042088)2.83784819
104positive regulation of regulated secretory pathway (GO:1903307)2.81619366
105reactive oxygen species biosynthetic process (GO:1903409)2.80381780
106regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.79944673
107phagocytosis, engulfment (GO:0006911)2.78469533
108regulation of myeloid leukocyte mediated immunity (GO:0002886)2.77955187
109positive regulation of leukocyte degranulation (GO:0043302)2.77605899
110regulation of tolerance induction (GO:0002643)2.76154107
111cyclooxygenase pathway (GO:0019371)2.74803416
112regulation of hypersensitivity (GO:0002883)2.73183023
113positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72997577
114positive regulation of chemokine biosynthetic process (GO:0045080)2.72769579
115B cell mediated immunity (GO:0019724)2.72362160
116negative regulation of B cell proliferation (GO:0030889)2.71054993
117negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.70634110
118negative regulation of bone resorption (GO:0045779)2.70384723
119negative regulation of leukocyte mediated immunity (GO:0002704)2.69405619
120glycolipid catabolic process (GO:0019377)2.68259299
121regulation of T-helper 2 cell differentiation (GO:0045628)2.67782314
122positive regulation of NF-kappaB import into nucleus (GO:0042346)2.67258908
123regulation of interleukin-17 production (GO:0032660)2.66830710
124antigen processing and presentation via MHC class Ib (GO:0002475)2.66485373
125macrophage chemotaxis (GO:0048246)2.64856105
126interferon-gamma-mediated signaling pathway (GO:0060333)2.64555464
127granulocyte chemotaxis (GO:0071621)2.62736381
128germinal center formation (GO:0002467)2.61842125
129pinocytosis (GO:0006907)2.61546909
130positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.61335941
131B cell receptor signaling pathway (GO:0050853)2.58961367
132positive regulation of macrophage cytokine production (GO:0060907)2.58538993
133positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.58412677
134leukocyte migration involved in inflammatory response (GO:0002523)2.58209545
135cytokine secretion (GO:0050663)2.58186183
136protein localization to endosome (GO:0036010)2.58127184
137regulation of interleukin-6 production (GO:0032675)2.57345301
138response to cholesterol (GO:0070723)2.56983912

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.33617392
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.91482088
3IRF8_27001747_Chip-Seq_BMDM_Mouse4.69935746
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.38029187
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.29235233
6* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.49239844
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.24397737
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21612368
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.16617641
10SCL_19346495_ChIP-Seq_HPC-7_Human2.97270246
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.95537500
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.91876024
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.80085374
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.69270790
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61220896
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46751747
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45794126
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41957418
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.28296195
20* SPI1_23127762_ChIP-Seq_K562_Human2.16277683
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13103714
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12537933
23* SPI1_23547873_ChIP-Seq_NB4_Human2.12459514
24RUNX_20019798_ChIP-Seq_JUKART_Human2.11364704
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.10013103
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02629470
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97510594
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.94828854
29VDR_24763502_ChIP-Seq_THP-1_Human1.90741329
30* RUNX1_22412390_ChIP-Seq_EML_Mouse1.74752428
31VDR_24787735_ChIP-Seq_THP-1_Human1.74059376
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68060679
33PU_27001747_Chip-Seq_BMDM_Mouse1.67820675
34PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67081278
35VDR_21846776_ChIP-Seq_THP-1_Human1.65974007
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63835032
37* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63318642
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.62074701
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.62074701
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.62074701
41NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.59401131
42MYB_26560356_Chip-Seq_TH2_Human1.56544720
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53107624
44TCF7_22412390_ChIP-Seq_EML_Mouse1.52305426
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50965553
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47243966
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.46053357
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44585808
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40820662
50MAF_26560356_Chip-Seq_TH1_Human1.40173183
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38835221
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37752479
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37752479
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37739404
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37080025
56* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36087066
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35579284
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33242820
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29006817
60MYB_26560356_Chip-Seq_TH1_Human1.26914405
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26641838
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.26481256
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23795849
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12888771
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12311743
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12027992
67* GATA3_27048872_Chip-Seq_THYMUS_Human1.11311869
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09737307
69SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07604879
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.06445851
71GATA3_26560356_Chip-Seq_TH2_Human1.06079666
72UTX_26944678_Chip-Seq_JUKART_Human1.05324670
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04628383
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04151190
75GATA2_19941826_ChIP-Seq_K562_Human1.03405361
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.02464906
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00030434
78GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98940623
79* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98870102
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97458848
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96175451
82* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95926973
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94522120
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.94053651
85KDM2B_26808549_Chip-Seq_DND41_Human0.93662083
86GATA1_19941826_ChIP-Seq_K562_Human0.92142376
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91557860
88TP63_23658742_ChIP-Seq_EP156T_Human0.91451305
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91448415
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90698290
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90583366
92PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90418667
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90373883
94ESR2_21235772_ChIP-Seq_MCF-7_Human0.90254404
95* BRD4_25478319_ChIP-Seq_HGPS_Human0.90231856
96P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88947543
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88725805
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88458136
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87714620
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86931734
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86631129
102SMAD_19615063_ChIP-ChIP_OVARY_Human0.86361123
103CDX2_20551321_ChIP-Seq_CACO-2_Human0.85435847
104GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84968321
105MAF_26560356_Chip-Seq_TH2_Human0.84896754
106CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83919720
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83091306
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83015051
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82528989
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.79597219
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79207429
112* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77196929
113EGR1_19032775_ChIP-ChIP_M12_Human0.76188477
114SMRT_27268052_Chip-Seq_Bcells_Human0.75946199
115SOX2_20726797_ChIP-Seq_SW620_Human0.75905090
116LXR_22292898_ChIP-Seq_THP-1_Human0.75215181
117GATA1_22025678_ChIP-Seq_K562_Human0.74929789
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70664314
119MYC_22102868_ChIP-Seq_BL_Human0.70236473
120CJUN_26792858_Chip-Seq_BT549_Human0.69143777
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.69019073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation4.24484830
2MP0003303_peritoneal_inflammation3.89175026
3MP0005058_abnormal_lysosome_morphology3.70548110
4MP0001835_abnormal_antigen_presentation3.68421442
5MP0003191_abnormal_cellular_cholesterol3.53894771
6MP0003436_decreased_susceptibility_to3.44864887
7MP0002419_abnormal_innate_immunity3.21986107
8MP0002148_abnormal_hypersensitivity_rea2.97837013
9MP0005671_abnormal_response_to2.94792071
10MP0005000_abnormal_immune_tolerance2.76935172
11MP0003172_abnormal_lysosome_physiology2.72335841
12MP0009785_altered_susceptibility_to2.70891554
13MP0005464_abnormal_platelet_physiology2.69159479
14MP0005025_abnormal_response_to2.53821889
15MP0002452_abnormal_antigen_presenting2.53407580
16MP0003724_increased_susceptibility_to2.53018771
17MP0003075_altered_response_to2.39495377
18MP0002723_abnormal_immune_serum2.32788947
19MP0001800_abnormal_humoral_immune2.31193536
20MP0001533_abnormal_skeleton_physiology2.23120902
21MP0003183_abnormal_peptide_metabolism2.14341295
22MP0001819_abnormal_immune_cell2.12972446
23MP0001790_abnormal_immune_system2.12132175
24MP0005387_immune_system_phenotype2.12132175
25MP0000343_altered_response_to2.09767319
26MP0002420_abnormal_adaptive_immunity2.09586106
27MP0009278_abnormal_bone_marrow2.06167306
28MP0000685_abnormal_immune_system2.04366202
29MP0003300_gastrointestinal_ulcer1.98193641
30MP0001853_heart_inflammation1.84769461
31MP0003690_abnormal_glial_cell1.80312188
32MP0002405_respiratory_system_inflammati1.79668282
33MP0001845_abnormal_inflammatory_respons1.76028263
34MP0005167_abnormal_blood-brain_barrier1.72841575
35MP0002877_abnormal_melanocyte_morpholog1.70603515
36MP0002254_reproductive_system_inflammat1.69788639
37MP0001851_eye_inflammation1.69476724
38MP0008004_abnormal_stomach_pH1.60632585
39MP0008469_abnormal_protein_level1.58399856
40MP0005409_darkened_coat_color1.57113271
41MP0004947_skin_inflammation1.55118060
42MP0005451_abnormal_body_composition1.50361560
43MP0000716_abnormal_immune_system1.50100936
44MP0002998_abnormal_bone_remodeling1.48664190
45MP0004510_myositis1.45525378
46MP0005166_decreased_susceptibility_to1.44422751
47MP0009840_abnormal_foam_cell1.43624142
48MP0010155_abnormal_intestine_physiology1.43335262
49MP0000465_gastrointestinal_hemorrhage1.41923334
50MP0004883_abnormal_blood_vessel1.41763542
51MP0003828_pulmonary_edema1.39925234
52MP0005397_hematopoietic_system_phenotyp1.38988296
53MP0001545_abnormal_hematopoietic_system1.38988296
54MP0009333_abnormal_splenocyte_physiolog1.37753451
55MP0005310_abnormal_salivary_gland1.36983662
56MP0001958_emphysema1.36887283
57MP0003448_altered_tumor_morphology1.35908383
58MP0002398_abnormal_bone_marrow1.33683378
59MP0002396_abnormal_hematopoietic_system1.33071857
60MP0006054_spinal_hemorrhage1.32802209
61MP0000689_abnormal_spleen_morphology1.29119725
62MP0003453_abnormal_keratinocyte_physiol1.26718845
63MP0000579_abnormal_nail_morphology1.24459319
64MP0002277_abnormal_respiratory_mucosa1.23986543
65MP0003705_abnormal_hypodermis_morpholog1.23302870
66MP0003566_abnormal_cell_adhesion1.22176113
67MP0000858_altered_metastatic_potential1.20855686
68MP0003656_abnormal_erythrocyte_physiolo1.20773728
69MP0009764_decreased_sensitivity_to1.20708964
70MP0002429_abnormal_blood_cell1.19357617
71MP0003763_abnormal_thymus_physiology1.18536066
72MP0003045_fibrosis1.16105841
73MP0000920_abnormal_myelination1.16084863
74MP0000015_abnormal_ear_pigmentation1.16072048
75MP0005275_abnormal_skin_tensile1.14802673
76MP0005390_skeleton_phenotype1.14153925
77MP0002722_abnormal_immune_system1.12999932
78MP0005023_abnormal_wound_healing1.12653257
79MP0002132_abnormal_respiratory_system1.11714856
80MP0005164_abnormal_response_to1.11597981
81MP0002060_abnormal_skin_morphology1.06965880
82MP0000681_abnormal_thyroid_gland1.05021912
83MP0002933_joint_inflammation0.99096336
84MP0010678_abnormal_skin_adnexa0.97855795
85MP0000383_abnormal_hair_follicle0.97131269
86MP0002090_abnormal_vision0.96821892
87MP0002006_tumorigenesis0.96230565
88MP0000249_abnormal_blood_vessel0.90235902
89MP0005174_abnormal_tail_pigmentation0.85364805
90MP0001849_ear_inflammation0.85302824
91MP0004264_abnormal_extraembryonic_tissu0.84152248
92MP0001216_abnormal_epidermal_layer0.83965974
93MP0008873_increased_physiological_sensi0.83786909
94MP0003011_delayed_dark_adaptation0.83484741
95MP0009763_increased_sensitivity_to0.82586806
96MP0008438_abnormal_cutaneous_collagen0.82581530
97MP0000767_abnormal_smooth_muscle0.82274855
98MP0005075_abnormal_melanosome_morpholog0.82247820
99MP0002928_abnormal_bile_duct0.81553057
100MP0000371_diluted_coat_color0.81518442
101MP0002166_altered_tumor_susceptibility0.80321623
102MP0003866_abnormal_defecation0.79327186
103MP0000604_amyloidosis0.77799119
104MP0004808_abnormal_hematopoietic_stem0.76492963
105MP0005388_respiratory_system_phenotype0.76058638
106MP0002133_abnormal_respiratory_system0.76058638
107MP0004858_abnormal_nervous_system0.74330509
108MP0003795_abnormal_bone_structure0.73103176
109MP0000490_abnormal_crypts_of0.72163034
110MP0000569_abnormal_digit_pigmentation0.71364442
111MP0001915_intracranial_hemorrhage0.70665778
112MP0004381_abnormal_hair_follicle0.69651188
113MP0004782_abnormal_surfactant_physiolog0.69204391
114MP0005257_abnormal_intraocular_pressure0.66913206
115MP0008260_abnormal_autophagy0.66886723
116MP0001324_abnormal_eye_pigmentation0.66719114
117MP0003091_abnormal_cell_migration0.66041464
118MP0005076_abnormal_cell_differentiation0.64893858
119MP0003279_aneurysm0.62862782
120MP0005197_abnormal_uvea_morphology0.62207989
121MP0005165_increased_susceptibility_to0.61721492
122MP0008874_decreased_physiological_sensi0.57039820
123MP0003634_abnormal_glial_cell0.55723960

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)8.14490624
2Recurrent abscess formation (HP:0002722)6.78531497
3Glomerulonephritis (HP:0000099)6.44617099
4Recurrent bacterial skin infections (HP:0005406)6.31829128
5Eczematoid dermatitis (HP:0000976)6.18006699
6Abnormality of glycolipid metabolism (HP:0010969)5.91689989
7Abnormality of liposaccharide metabolism (HP:0010968)5.91689989
8Abnormality of glycosphingolipid metabolism (HP:0004343)5.91689989
9Increased cerebral lipofuscin (HP:0011813)4.94169297
10Recurrent gram-negative bacterial infections (HP:0005420)4.89160790
11Increased neuronal autofluorescent lipopigment (HP:0002074)4.83013970
12Abnormality of macrophages (HP:0004311)4.22776962
13Complement deficiency (HP:0004431)4.21664176
14Dysostosis multiplex (HP:0000943)3.94575231
15Recurrent skin infections (HP:0001581)3.89926056
16Vacuolated lymphocytes (HP:0001922)3.77256083
17Arterial tortuosity (HP:0005116)3.75424113
18Retinal atrophy (HP:0001105)3.69022587
19Axonal loss (HP:0003447)3.65867518
20Elevated erythrocyte sedimentation rate (HP:0003565)3.64593321
21Myositis (HP:0100614)3.64187796
22Milia (HP:0001056)3.63575837
23Abnormality of complement system (HP:0005339)3.62487758
24Hematochezia (HP:0002573)3.58829473
25Nephritis (HP:0000123)3.56500062
26Mutism (HP:0002300)3.54212346
27Disinhibition (HP:0000734)3.50525821
28Mediastinal lymphadenopathy (HP:0100721)3.38409083
29Obstructive lung disease (HP:0006536)3.30354934
30Chronic obstructive pulmonary disease (HP:0006510)3.30354934
31Gingivitis (HP:0000230)3.30138346
32Vascular tortuosity (HP:0004948)3.26840470
33Orchitis (HP:0100796)3.21536322
34Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.18645295
35Recurrent fungal infections (HP:0002841)3.16449579
36Onycholysis (HP:0001806)3.15994376
37Cerebral aneurysm (HP:0004944)3.10043714
38Colitis (HP:0002583)3.02713560
39Stomatitis (HP:0010280)3.02433193
40Atrophic scars (HP:0001075)3.00798863
41Peritonitis (HP:0002586)2.98870065
42Urinary glycosaminoglycan excretion (HP:0003541)2.88950296
43Mucopolysacchariduria (HP:0008155)2.88950296
44Cellulitis (HP:0100658)2.83916101
45Keratoconjunctivitis sicca (HP:0001097)2.81986525
46Agnosia (HP:0010524)2.81507031
47Abnormality of mucopolysaccharide metabolism (HP:0011020)2.77949219
48Abnormality of polysaccharide metabolism (HP:0011012)2.77949219
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.77949219
50Amyloidosis (HP:0011034)2.75686616
51Hepatosplenomegaly (HP:0001433)2.74627371
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.74192764
53Fragile nails (HP:0001808)2.71745541
54Plantar hyperkeratosis (HP:0007556)2.71625236
55Epistaxis (HP:0000421)2.70058333
56Prolonged bleeding time (HP:0003010)2.69448974
57Gastrointestinal infarctions (HP:0005244)2.66369412
58Inflammation of the large intestine (HP:0002037)2.62076457
59Optic neuritis (HP:0100653)2.55957785
60Retrobulbar optic neuritis (HP:0100654)2.55957785
61Keratoconjunctivitis (HP:0001096)2.55448372
62Chronic mucocutaneous candidiasis (HP:0002728)2.53372776
63Recurrent cutaneous fungal infections (HP:0011370)2.53372776
64Chest pain (HP:0100749)2.51388516
65Chronic diarrhea (HP:0002028)2.50798563
66Recurrent viral infections (HP:0004429)2.50796916
67Thick nail (HP:0001805)2.49264834
68Spontaneous hematomas (HP:0007420)2.44942741
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.40422553
70Hemoptysis (HP:0002105)2.40422110
71Interstitial pulmonary disease (HP:0006530)2.39265881
72Gastrointestinal inflammation (HP:0004386)2.37936678
73Vasculitis (HP:0002633)2.36645555
74Neuronal loss in central nervous system (HP:0002529)2.34972975
75Basal ganglia calcification (HP:0002135)2.34538433
76Progressive visual loss (HP:0000529)2.32181951
77Urticaria (HP:0001025)2.29538897
78Skin ulcer (HP:0200042)2.28777006
79Upper motor neuron abnormality (HP:0002127)2.27751701
80Meningitis (HP:0001287)2.26106716
81Disproportionate tall stature (HP:0001519)2.25594807
82Loss of speech (HP:0002371)2.24164942
83Progressive neurologic deterioration (HP:0002344)2.21839104
84Aortic aneurysm (HP:0004942)2.21503576
85Pustule (HP:0200039)2.20834681
86T lymphocytopenia (HP:0005403)2.19316528
87Abnormal blistering of the skin (HP:0008066)2.17413388
88Pathologic fracture (HP:0002756)2.14502757
89Cheilitis (HP:0100825)2.12799207
90Encephalitis (HP:0002383)2.11753946
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10921153
92Osteomyelitis (HP:0002754)2.10793506
93Urethral obstruction (HP:0000796)2.09804288
94Premature loss of primary teeth (HP:0006323)2.09801834
95Abnormality of T cell number (HP:0011839)2.09484569
96Leukocytosis (HP:0001974)2.09006439
97Petechiae (HP:0000967)2.07900528
98Recurrent pneumonia (HP:0006532)2.07826466
99Periodontitis (HP:0000704)2.06899042
100Abnormal platelet volume (HP:0011876)2.04505398
101Orthostatic hypotension (HP:0001278)2.04374857
102Episodic fever (HP:0001954)2.03263362
103Increased IgE level (HP:0003212)2.02363665
104Abnormality of nail color (HP:0100643)1.99356151
105Abnormality of the peritoneum (HP:0002585)1.98124381
106Viral hepatitis (HP:0006562)1.96366624
107Thrombocytosis (HP:0001894)1.95322367
108Chronic otitis media (HP:0000389)1.94322517
109Subacute progressive viral hepatitis (HP:0006572)1.93264942
110Pulmonary infiltrates (HP:0002113)1.92916005
111Prostate neoplasm (HP:0100787)1.92497295
112Spondylolisthesis (HP:0003302)1.89603240
113Nail dystrophy (HP:0008404)1.89564547
114Inappropriate behavior (HP:0000719)1.88258770
115Pulmonary embolism (HP:0002204)1.84725725
116Thoracic kyphosis (HP:0002942)1.84279322
117Apathy (HP:0000741)1.84167100
118Aortic dissection (HP:0002647)1.83773705
119Peripheral demyelination (HP:0011096)1.83618606
120Recurrent lower respiratory tract infections (HP:0002783)1.83020573
121Arterial thrombosis (HP:0004420)1.82125116
122Diminished motivation (HP:0000745)1.81386239
123Osteolytic defects of the hand bones (HP:0009699)1.80696112
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.80696112
125Glomerulopathy (HP:0100820)1.80596752
126Bruising susceptibility (HP:0000978)1.79731266
127Myocardial infarction (HP:0001658)1.79652871
128Thickened calvaria (HP:0002684)1.79368487
129Gingival bleeding (HP:0000225)1.78969690
130Striae distensae (HP:0001065)1.78699480
131Impaired platelet aggregation (HP:0003540)1.78322872
132Abnormal platelet function (HP:0011869)1.78322872
133Alopecia of scalp (HP:0002293)1.77916993
134Palmoplantar hyperkeratosis (HP:0000972)1.76779125
135Eosinophilia (HP:0001880)1.76043504
136Granulocytopenia (HP:0001913)1.75637102
137Polycythemia (HP:0001901)1.75157741
138Pili torti (HP:0003777)1.73940271

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR26.61800050
2GRK73.61833906
3CSF1R3.53649441
4RIPK43.45482550
5BLK3.44482748
6MAPK153.06237557
7IRAK42.80436744
8TYK22.60318911
9TBK12.21619804
10STK102.09848152
11ERN12.06366867
12MAP3K22.03227618
13MAP3K141.85611045
14MATK1.83872361
15CSK1.74524177
16ADRBK21.73660113
17IRAK31.73432036
18KIT1.72648423
19TAOK31.64349655
20EPHB11.62685023
21PAK41.60789788
22MAP4K11.58288188
23KSR21.57280652
24IKBKB1.57012583
25HCK1.45589351
26MAP2K31.43129544
27JAK11.41998264
28CLK11.40899930
29ZAP701.40674467
30ITK1.39908626
31MOS1.38436128
32PRPF4B1.38178332
33GRK51.34374425
34MAPKAPK31.24535915
35CAMK1D1.19123351
36FES1.18284595
37IKBKE1.17012416
38FGR1.16849466
39TRPM71.16661684
40MAP3K131.15933512
41MAP3K11.15234493
42EEF2K1.14637062
43BTK1.13669183
44LYN1.13591821
45TXK1.05614104
46MAPKAPK51.04895295
47TEC0.98707172
48TRIB30.96377660
49MAPK120.96226097
50JAK20.95482871
51RPS6KA40.95321239
52LCK0.93231525
53TTN0.90000853
54MARK30.88637365
55SYK0.88516606
56SIK20.88436716
57GRK10.85849428
58PTK2B0.85572992
59RAF10.84099904
60MAPK70.83232532
61RET0.82617409
62TSSK60.78940549
63CDK120.78731512
64PBK0.77621264
65MAP3K60.77064367
66CAMK1G0.74664856
67PRKD20.74437233
68TNK20.72649555
69MAP3K110.71961548
70CDK30.70624617
71RPS6KC10.69078241
72RPS6KL10.69078241
73RPS6KA20.68143798
74MAP3K50.67433472
75TAOK10.66496178
76LRRK20.66477251
77SGK30.66294700
78PIM20.65901899
79CDC42BPA0.63799642
80JAK30.63261078
81WNK10.63243139
82EIF2AK20.63174056
83GRK60.61651648
84CHUK0.59990947
85SIK10.59942271
86IGF1R0.59722943
87RPS6KA60.59551847
88YES10.58664166
89CAMK40.58390359
90PDGFRB0.57491345
91VRK10.56302397
92FLT30.54999558
93EGFR0.54590829
94IRAK20.53624005
95IRAK10.51788672
96MAP3K30.51509818
97FGFR30.50683814
98STK240.50089920
99MST1R0.47431392
100SGK20.46829680
101CAMKK20.46762800
102MAP3K100.45071037
103HIPK20.44434774
104KSR10.44276705
105MARK20.44020440
106NEK90.43651389
107PDK10.43033665
108ABL10.42820682
109FER0.42188308
110PRKG20.41713923
111MAP2K40.40978189
112PRKCD0.40732168
113ARAF0.40062245
114* MAPKAPK20.39838179
115PDK20.39202347
116LMTK20.39121829
117MAP3K70.39095130
118STK380.38972048
119MST40.36447329
120MAPK40.35849327
121BMPR20.35735462
122PRKCQ0.35429806
123GSK3A0.35307106
124SMG10.34732194
125RIPK10.34727662
126PIM10.34523146
127PIK3CG0.34382143
128PTK60.34319935
129CDK60.34140563
130INSR0.31853978
131ERBB30.30574224
132FYN0.30174164
133STK40.27876232
134MAP2K20.26666885
135SIK30.25735403
136PDPK10.24050134
137PRKAA20.23984342
138PAK20.23734889
139PKN20.23592926

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.32580068
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.24480517
3Other glycan degradation_Homo sapiens_hsa005113.17411740
4Leishmaniasis_Homo sapiens_hsa051403.11863486
5Osteoclast differentiation_Homo sapiens_hsa043802.80840847
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.77781498
7Pertussis_Homo sapiens_hsa051332.53512476
8Lysosome_Homo sapiens_hsa041422.35130619
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.28486811
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.28324240
11Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.06441885
12B cell receptor signaling pathway_Homo sapiens_hsa046621.99539599
13Tuberculosis_Homo sapiens_hsa051521.95157411
14Legionellosis_Homo sapiens_hsa051341.94170536
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88395903
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87987701
17Autoimmune thyroid disease_Homo sapiens_hsa053201.73646122
18Toxoplasmosis_Homo sapiens_hsa051451.63539780
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.60580247
20Malaria_Homo sapiens_hsa051441.60047966
21Hematopoietic cell lineage_Homo sapiens_hsa046401.56734507
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46903144
23Measles_Homo sapiens_hsa051621.46484481
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45565468
25Salmonella infection_Homo sapiens_hsa051321.44884909
26Influenza A_Homo sapiens_hsa051641.44703260
27Chemokine signaling pathway_Homo sapiens_hsa040621.42672032
28Prion diseases_Homo sapiens_hsa050201.42585670
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42281564
30Antigen processing and presentation_Homo sapiens_hsa046121.38455244
31Rheumatoid arthritis_Homo sapiens_hsa053231.36450620
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31243242
33Phagosome_Homo sapiens_hsa041451.30453623
34TNF signaling pathway_Homo sapiens_hsa046681.29925446
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.27950854
36Graft-versus-host disease_Homo sapiens_hsa053321.27463872
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15862737
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13232384
39Pancreatic cancer_Homo sapiens_hsa052121.11412839
40Complement and coagulation cascades_Homo sapiens_hsa046101.08152407
41Asthma_Homo sapiens_hsa053101.08068554
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.06430668
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06170904
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03867687
45Apoptosis_Homo sapiens_hsa042101.00721978
46Shigellosis_Homo sapiens_hsa051310.99446331
47African trypanosomiasis_Homo sapiens_hsa051430.98318334
48Allograft rejection_Homo sapiens_hsa053300.97371063
49Platelet activation_Homo sapiens_hsa046110.97351181
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.97113766
51Chronic myeloid leukemia_Homo sapiens_hsa052200.93292847
52Herpes simplex infection_Homo sapiens_hsa051680.93243638
53Hepatitis B_Homo sapiens_hsa051610.91540143
54Focal adhesion_Homo sapiens_hsa045100.86676987
55Acute myeloid leukemia_Homo sapiens_hsa052210.83825451
56Amoebiasis_Homo sapiens_hsa051460.81253045
57ECM-receptor interaction_Homo sapiens_hsa045120.80359342
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.79161345
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.79081560
60Endocytosis_Homo sapiens_hsa041440.78629032
61Bladder cancer_Homo sapiens_hsa052190.75006297
62Arachidonic acid metabolism_Homo sapiens_hsa005900.74506067
63Hepatitis C_Homo sapiens_hsa051600.71268042
64GnRH signaling pathway_Homo sapiens_hsa049120.70466331
65T cell receptor signaling pathway_Homo sapiens_hsa046600.70417438
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69766896
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69512129
68Endometrial cancer_Homo sapiens_hsa052130.62969556
69Colorectal cancer_Homo sapiens_hsa052100.60920647
70ABC transporters_Homo sapiens_hsa020100.59274607
71Renal cell carcinoma_Homo sapiens_hsa052110.58863401
72Insulin resistance_Homo sapiens_hsa049310.58294946
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58173792
74Notch signaling pathway_Homo sapiens_hsa043300.57982518
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57954824
76Glioma_Homo sapiens_hsa052140.57765248
77mTOR signaling pathway_Homo sapiens_hsa041500.57104232
78ErbB signaling pathway_Homo sapiens_hsa040120.56202879
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55792531
80Primary immunodeficiency_Homo sapiens_hsa053400.54337994
81VEGF signaling pathway_Homo sapiens_hsa043700.54052466
82Sphingolipid metabolism_Homo sapiens_hsa006000.53359589
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52870365
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51994793
85Thyroid cancer_Homo sapiens_hsa052160.51913198
86Adherens junction_Homo sapiens_hsa045200.51523597
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51416583
88Prostate cancer_Homo sapiens_hsa052150.51265231
89Thyroid hormone synthesis_Homo sapiens_hsa049180.50400762
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49359763
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49076960
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.48285724
93Type I diabetes mellitus_Homo sapiens_hsa049400.47269125
94Viral myocarditis_Homo sapiens_hsa054160.46317570
95Rap1 signaling pathway_Homo sapiens_hsa040150.45575769
96Viral carcinogenesis_Homo sapiens_hsa052030.45273949
97Prolactin signaling pathway_Homo sapiens_hsa049170.43523753
98MAPK signaling pathway_Homo sapiens_hsa040100.43252575
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.40809897
100* Ether lipid metabolism_Homo sapiens_hsa005650.39171582
101Inositol phosphate metabolism_Homo sapiens_hsa005620.36783244
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35510993
103Dorso-ventral axis formation_Homo sapiens_hsa043200.34516638
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33739851
105Non-small cell lung cancer_Homo sapiens_hsa052230.33196205
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32691953
107Proteoglycans in cancer_Homo sapiens_hsa052050.31001784
108FoxO signaling pathway_Homo sapiens_hsa040680.30624917
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30390647
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28809498
111Small cell lung cancer_Homo sapiens_hsa052220.27912700
112Epstein-Barr virus infection_Homo sapiens_hsa051690.27622611
113Pathways in cancer_Homo sapiens_hsa052000.27499826
114Ras signaling pathway_Homo sapiens_hsa040140.26549752
115Estrogen signaling pathway_Homo sapiens_hsa049150.25734172
116HIF-1 signaling pathway_Homo sapiens_hsa040660.24603796
117Mineral absorption_Homo sapiens_hsa049780.24508720
118Choline metabolism in cancer_Homo sapiens_hsa052310.23044018

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