LPCAT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.45966336
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.06871828
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.87919982
4locomotory exploration behavior (GO:0035641)5.65567150
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.52611562
6synaptic vesicle exocytosis (GO:0016079)5.38697419
7regulation of synaptic vesicle exocytosis (GO:2000300)5.25434561
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.21655498
9glutamate secretion (GO:0014047)5.21248446
10vocalization behavior (GO:0071625)5.10180503
11cerebellar granule cell differentiation (GO:0021707)4.98845518
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.80468239
13neuronal action potential propagation (GO:0019227)4.72101270
14regulation of synaptic vesicle transport (GO:1902803)4.65927505
15regulation of long-term neuronal synaptic plasticity (GO:0048169)4.61997816
16regulation of synapse structural plasticity (GO:0051823)4.60928651
17regulation of glutamate receptor signaling pathway (GO:1900449)4.50422017
18regulation of neuronal synaptic plasticity (GO:0048168)4.44939984
19neurotransmitter secretion (GO:0007269)4.32507315
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.26001406
21sodium ion export (GO:0071436)4.24624301
22regulation of synapse maturation (GO:0090128)4.24139540
23protein localization to synapse (GO:0035418)4.20691275
24cellular potassium ion homeostasis (GO:0030007)4.12441659
25exploration behavior (GO:0035640)4.10432251
26cerebellar Purkinje cell layer development (GO:0021680)4.09959389
27positive regulation of membrane potential (GO:0045838)4.05247246
28positive regulation of dendritic spine morphogenesis (GO:0061003)4.02817945
29cell migration in hindbrain (GO:0021535)4.01433216
30L-amino acid import (GO:0043092)3.95087471
31synaptic transmission, glutamatergic (GO:0035249)3.91752368
32potassium ion homeostasis (GO:0055075)3.84872214
33long-term memory (GO:0007616)3.77852441
34G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.75594189
35neuron-neuron synaptic transmission (GO:0007270)3.75487464
36layer formation in cerebral cortex (GO:0021819)3.75446504
37positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.73401989
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71228466
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.68494707
40neuromuscular process controlling balance (GO:0050885)3.67534961
41regulation of synaptic plasticity (GO:0048167)3.66533997
42cellular sodium ion homeostasis (GO:0006883)3.66416806
43glutamate receptor signaling pathway (GO:0007215)3.65147787
44amino acid import (GO:0043090)3.63797687
45cell communication involved in cardiac conduction (GO:0086065)3.62144316
46prepulse inhibition (GO:0060134)3.61232554
47dendritic spine morphogenesis (GO:0060997)3.60510617
48positive regulation of synapse maturation (GO:0090129)3.49384296
49regulation of postsynaptic membrane potential (GO:0060078)3.47161288
50neuromuscular process controlling posture (GO:0050884)3.41149930
51positive regulation of dendritic spine development (GO:0060999)3.40805918
52activation of protein kinase A activity (GO:0034199)3.40292683
53neurotransmitter-gated ion channel clustering (GO:0072578)3.39585686
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.38457067
55regulation of dendritic spine morphogenesis (GO:0061001)3.38318103
56cerebellar Purkinje cell differentiation (GO:0021702)3.38164882
57positive regulation of neurotransmitter transport (GO:0051590)3.37786646
58neuron cell-cell adhesion (GO:0007158)3.36221515
59regulation of neurotransmitter secretion (GO:0046928)3.33437616
60regulation of vesicle fusion (GO:0031338)3.31655684
61long-term synaptic potentiation (GO:0060291)3.31653804
62signal complex assembly (GO:0007172)3.31254546
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.31118828
64positive regulation of neurotransmitter secretion (GO:0001956)3.29525956
65auditory behavior (GO:0031223)3.26237816
66neurotransmitter transport (GO:0006836)3.26212217
67gamma-aminobutyric acid transport (GO:0015812)3.20439411
68negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19960163
69cell differentiation in hindbrain (GO:0021533)3.19346543
70regulation of voltage-gated calcium channel activity (GO:1901385)3.15703549
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.14578343
72regulation of neurotransmitter transport (GO:0051588)3.13279631
73regulation of clathrin-mediated endocytosis (GO:2000369)3.12749680
74regulation of neurotransmitter levels (GO:0001505)3.09732824
75regulation of ARF protein signal transduction (GO:0032012)3.09235977
76gamma-aminobutyric acid signaling pathway (GO:0007214)3.09117856
77positive regulation of vesicle fusion (GO:0031340)3.04817389
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.04493100
79proline transport (GO:0015824)3.02771891
80postsynaptic membrane organization (GO:0001941)3.02570767
81membrane hyperpolarization (GO:0060081)3.01144726
82membrane depolarization during action potential (GO:0086010)3.00219964
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99928594
84transmission of nerve impulse (GO:0019226)2.99290531
85potassium ion import (GO:0010107)2.98764262
86neuronal ion channel clustering (GO:0045161)2.98183691
87response to histamine (GO:0034776)2.96681619
88adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.96494844
89membrane depolarization (GO:0051899)2.95786784
90cytoskeletal anchoring at plasma membrane (GO:0007016)2.95494891
91synaptic vesicle endocytosis (GO:0048488)2.94713050
92long term synaptic depression (GO:0060292)2.94484865
93response to auditory stimulus (GO:0010996)2.94100580
94neuromuscular process (GO:0050905)2.92660408
95neuron recognition (GO:0008038)2.92608564
96chemosensory behavior (GO:0007635)2.92186508
97positive regulation of synaptic transmission, GABAergic (GO:0032230)2.90826376
98dopamine receptor signaling pathway (GO:0007212)2.90805529
99negative regulation of microtubule polymerization (GO:0031115)2.89907414
100dendritic spine organization (GO:0097061)2.89400126
101positive regulation of synaptic transmission (GO:0050806)2.88142487
102glycine transport (GO:0015816)2.86042014
103central nervous system myelination (GO:0022010)2.84443774
104axon ensheathment in central nervous system (GO:0032291)2.84443774
105regulation of synaptic transmission (GO:0050804)2.83915270
106positive regulation of fibroblast migration (GO:0010763)2.83654732
107regulation of cell communication by electrical coupling (GO:0010649)2.83559286
108negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82198720
109negative regulation of dendrite morphogenesis (GO:0050774)2.80744605
110regulation of dendritic spine development (GO:0060998)2.80639752
111behavioral fear response (GO:0001662)2.79551740
112behavioral defense response (GO:0002209)2.79551740
113cell communication by electrical coupling (GO:0010644)2.79089619
114learning (GO:0007612)2.78657118
115visual learning (GO:0008542)2.78058460
116negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.77991250
117regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.77984182
118serotonin metabolic process (GO:0042428)2.77437010
119vesicle transport along microtubule (GO:0047496)2.76877871
120synaptic transmission (GO:0007268)2.75821795
121synaptic transmission, dopaminergic (GO:0001963)2.75540106
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73352298
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.72981315
124mating behavior (GO:0007617)2.72082956
125establishment of mitochondrion localization (GO:0051654)2.65913892
126mitochondrion transport along microtubule (GO:0047497)2.63390996
127establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.63390996
128activation of Rac GTPase activity (GO:0032863)2.63181052
129positive regulation of dendrite development (GO:1900006)2.61556554
130regulation of ARF GTPase activity (GO:0032312)2.61094438
131detection of calcium ion (GO:0005513)2.60525906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.73225338
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.74776351
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.52090520
4IKZF1_21737484_ChIP-ChIP_HCT116_Human3.38566403
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.18557313
6DROSHA_22980978_ChIP-Seq_HELA_Human2.98330173
7REST_21632747_ChIP-Seq_MESCs_Mouse2.81106013
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73223839
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68294727
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59466960
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47145841
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47145841
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46295305
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.45040484
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43018406
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41011782
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36439263
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26430069
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16175488
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.15033710
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04117027
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.99817849
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.99157934
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98617539
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.97139216
26DNAJC2_21179169_ChIP-ChIP_NT2_Human1.96228012
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93865678
28GBX2_23144817_ChIP-Seq_PC3_Human1.93324759
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.87333626
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.86328418
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84387080
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82178808
33EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.77662968
34KDM2B_26808549_Chip-Seq_K562_Human1.75540245
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75240329
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74378038
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.72626060
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64014551
39GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60546925
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59867628
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.59353193
42RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.57784025
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57668754
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55086329
45KDM2B_26808549_Chip-Seq_DND41_Human1.52859789
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.51455222
47SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50708335
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.49807839
49LXR_22292898_ChIP-Seq_THP-1_Human1.44620544
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.42983979
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42927593
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.40506830
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39516641
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.38436253
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.36699751
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34004984
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32166003
58PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30846433
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.27399865
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26935961
61CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26201824
62TET1_21490601_ChIP-Seq_MESCs_Mouse1.25495842
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25490632
64ZNF263_19887448_ChIP-Seq_K562_Human1.21515056
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21101801
66SA1_27219007_Chip-Seq_Bcells_Human1.19065059
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18921915
68SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18293298
69TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16806751
70AR_21572438_ChIP-Seq_LNCaP_Human1.15178574
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.14473723
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14303738
73SMC4_20622854_ChIP-Seq_HELA_Human1.13927363
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13858781
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12132682
76CTCF_27219007_Chip-Seq_Bcells_Human1.09696201
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09685308
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09048894
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08844093
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07126107
81* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06585907
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03678475
83SMAD4_21799915_ChIP-Seq_A2780_Human1.03573036
84AR_19668381_ChIP-Seq_PC3_Human1.03089469
85TP63_22573176_ChIP-Seq_HFKS_Human1.03062723
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02513411
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02120479
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99701839
89RXR_22108803_ChIP-Seq_LS180_Human0.99455664
90P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99321344
91MYC_22102868_ChIP-Seq_BL_Human0.98638324
92P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98336956
93* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98291569
94SMAD4_21741376_ChIP-Seq_ESCs_Human0.97777919
95SPI1_23127762_ChIP-Seq_K562_Human0.97561769
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97215372
97CDX2_20551321_ChIP-Seq_CACO-2_Human0.96736434
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96230583
99TP53_20018659_ChIP-ChIP_R1E_Mouse0.95374307
100TCF7_22412390_ChIP-Seq_EML_Mouse0.95225246
101CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93818743
102CTCF_20526341_ChIP-Seq_ESCs_Human0.93294501
103GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92899234
104SOX2_21211035_ChIP-Seq_LN229_Gbm0.92481759
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92376058
106OCT4_19829295_ChIP-Seq_ESCs_Human0.90033652
107BCL6_27268052_Chip-Seq_Bcells_Human0.89272820
108* ELF1_20517297_ChIP-Seq_JURKAT_Human0.89225053
109* E2F1_20622854_ChIP-Seq_HELA_Human0.89118025
110* CREB1_26743006_Chip-Seq_LNCaP_Human0.88469123
111* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88447345
112BCOR_27268052_Chip-Seq_Bcells_Human0.88234411
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87447650
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.87270556
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86270678
116DPY_21335234_ChIP-Seq_ESCs_Mouse0.85671066
117KLF4_19829295_ChIP-Seq_ESCs_Human0.85615289
118GATA1_26923725_Chip-Seq_HPCs_Mouse0.83665763
119RUNX_20019798_ChIP-Seq_JUKART_Human0.80410598
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.80405612
121RACK7_27058665_Chip-Seq_MCF-7_Human0.80372282
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.79809175
123E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.77044977
124TP53_16413492_ChIP-PET_HCT116_Human0.76893491
125P68_20966046_ChIP-Seq_HELA_Human0.76890638
126TP53_23651856_ChIP-Seq_MEFs_Mouse0.76610345
127STAT3_23295773_ChIP-Seq_U87_Human0.76514498
128ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76473123
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.76353319
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76295481
131ESR2_21235772_ChIP-Seq_MCF-7_Human0.75962484
132SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.75651684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.25930377
2MP0003880_abnormal_central_pattern4.50991819
3MP0003635_abnormal_synaptic_transmissio4.29204641
4MP0002822_catalepsy4.26456729
5MP0004270_analgesia3.63864486
6MP0009745_abnormal_behavioral_response3.43466376
7MP0002063_abnormal_learning/memory/cond3.30631070
8MP0009046_muscle_twitch3.25452075
9MP0002064_seizures3.21508517
10MP0001968_abnormal_touch/_nociception2.95835636
11MP0002572_abnormal_emotion/affect_behav2.63610358
12MP0002272_abnormal_nervous_system2.47036238
13MP0002734_abnormal_mechanical_nocicepti2.37361939
14MP0001486_abnormal_startle_reflex2.29166189
15MP0008569_lethality_at_weaning2.28410092
16MP0003329_amyloid_beta_deposits2.26254411
17MP0002736_abnormal_nociception_after2.25513677
18MP0005423_abnormal_somatic_nervous2.14535156
19MP0002909_abnormal_adrenal_gland2.11597404
20MP0001501_abnormal_sleep_pattern2.10890768
21MP0010234_abnormal_vibrissa_follicle2.02126226
22MP0001970_abnormal_pain_threshold1.99957495
23MP0002733_abnormal_thermal_nociception1.96026140
24MP0002735_abnormal_chemical_nociception1.94310562
25MP0004510_myositis1.86287888
26MP0004811_abnormal_neuron_physiology1.86174112
27MP0004858_abnormal_nervous_system1.83836919
28MP0000566_synostosis1.79903705
29MP0003879_abnormal_hair_cell1.78642240
30MP0001440_abnormal_grooming_behavior1.71570157
31MP0009379_abnormal_foot_pigmentation1.70522052
32MP0000751_myopathy1.65373036
33MP0002067_abnormal_sensory_capabilities1.64661171
34MP0002184_abnormal_innervation1.55189913
35MP0003122_maternal_imprinting1.54255757
36MP0005386_behavior/neurological_phenoty1.51758075
37MP0004924_abnormal_behavior1.51758075
38MP0001984_abnormal_olfaction1.49267598
39MP0005409_darkened_coat_color1.46516782
40MP0002557_abnormal_social/conspecific_i1.41638758
41MP0003633_abnormal_nervous_system1.38653951
42MP0000955_abnormal_spinal_cord1.30307547
43MP0001529_abnormal_vocalization1.28541984
44MP0002066_abnormal_motor_capabilities/c1.28050945
45MP0008872_abnormal_physiological_respon1.26202445
46MP0005623_abnormal_meninges_morphology1.24977361
47MP0003787_abnormal_imprinting1.19992809
48MP0003183_abnormal_peptide_metabolism1.19949013
49MP0002882_abnormal_neuron_morphology1.17683250
50MP0009780_abnormal_chondrocyte_physiolo1.13965306
51MP0003631_nervous_system_phenotype1.13206070
52MP0003075_altered_response_to1.10498277
53MP0005310_abnormal_salivary_gland1.07561059
54MP0008874_decreased_physiological_sensi1.06057760
55MP0008961_abnormal_basal_metabolism1.04347470
56MP0004885_abnormal_endolymph1.03054548
57MP0001849_ear_inflammation1.01752742
58MP0001905_abnormal_dopamine_level0.97737727
59MP0003705_abnormal_hypodermis_morpholog0.97256941
60MP0005646_abnormal_pituitary_gland0.96594582
61MP0000778_abnormal_nervous_system0.96354118
62MP0002152_abnormal_brain_morphology0.95644610
63MP0000604_amyloidosis0.92884090
64MP0000678_abnormal_parathyroid_gland0.90222174
65MP0001502_abnormal_circadian_rhythm0.90105906
66MP0004043_abnormal_pH_regulation0.89958284
67MP0000569_abnormal_digit_pigmentation0.89807218
68MP0005671_abnormal_response_to0.89584651
69MP0000579_abnormal_nail_morphology0.89577602
70MP0003045_fibrosis0.88810006
71MP0004142_abnormal_muscle_tone0.88253558
72MP0001765_abnormal_ion_homeostasis0.87110194
73MP0000920_abnormal_myelination0.86316424
74MP0003137_abnormal_impulse_conducting0.86142759
75MP0001348_abnormal_lacrimal_gland0.85641469
76MP0000537_abnormal_urethra_morphology0.82983150
77MP0004145_abnormal_muscle_electrophysio0.82623250
78MP0003866_abnormal_defecation0.81028767
79MP0002089_abnormal_postnatal_growth/wei0.75956470
80MP0005167_abnormal_blood-brain_barrier0.75692090
81MP0003690_abnormal_glial_cell0.74193354
82MP0002069_abnormal_eating/drinking_beha0.73801236
83MP0001346_abnormal_lacrimal_gland0.73786872
84MP0003172_abnormal_lysosome_physiology0.73753490
85MP0003632_abnormal_nervous_system0.72900217
86MP0005394_taste/olfaction_phenotype0.72166743
87MP0005499_abnormal_olfactory_system0.72166743
88MP0002249_abnormal_larynx_morphology0.71757658
89MP0000013_abnormal_adipose_tissue0.71193174
90MP0005166_decreased_susceptibility_to0.70984555
91MP0003303_peritoneal_inflammation0.70801892
92MP0002653_abnormal_ependyma_morphology0.70524684
93MP0003763_abnormal_thymus_physiology0.70152589
94MP0001485_abnormal_pinna_reflex0.68658196
95MP0004215_abnormal_myocardial_fiber0.68115521
96MP0000003_abnormal_adipose_tissue0.66612448
97MP0002169_no_abnormal_phenotype0.66064446
98MP0004084_abnormal_cardiac_muscle0.65759088
99MP0003121_genomic_imprinting0.64379728
100MP0001177_atelectasis0.63911770
101MP0003119_abnormal_digestive_system0.62983206
102MP0001188_hyperpigmentation0.62494621
103MP0002229_neurodegeneration0.61212370
104MP0006276_abnormal_autonomic_nervous0.60998395
105MP0000462_abnormal_digestive_system0.60163441
106MP0001986_abnormal_taste_sensitivity0.59888245
107MP0000762_abnormal_tongue_morphology0.57915234
108MP0002752_abnormal_somatic_nervous0.57510637
109MP0002082_postnatal_lethality0.57369562
110MP0010770_preweaning_lethality0.57369562
111MP0004742_abnormal_vestibular_system0.57017874
112MP0000534_abnormal_ureter_morphology0.55597210
113MP0008877_abnormal_DNA_methylation0.54571993
114MP0003634_abnormal_glial_cell0.53523972
115MP0001943_abnormal_respiration0.52374649
116MP0010769_abnormal_survival0.52148345
117MP0003283_abnormal_digestive_organ0.52072285
118MP0001664_abnormal_digestion0.51670423
119MP0003123_paternal_imprinting0.51301609
120MP0008770_decreased_survivor_rate0.50505627
121MP0004085_abnormal_heartbeat0.49624118
122MP0010768_mortality/aging0.49500340
123MP0001299_abnormal_eye_distance/0.48436751
124MP0001873_stomach_inflammation0.47541050
125MP0005645_abnormal_hypothalamus_physiol0.47277195
126MP0003861_abnormal_nervous_system0.45131773
127MP0003956_abnormal_body_size0.44966945
128MP0002873_normal_phenotype0.44730296
129MP0001963_abnormal_hearing_physiology0.44449025

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.39332040
2Focal motor seizures (HP:0011153)6.95425606
3Focal seizures (HP:0007359)5.52446167
4Visual hallucinations (HP:0002367)4.59687965
5Atonic seizures (HP:0010819)4.26979035
6Epileptic encephalopathy (HP:0200134)3.98518530
7Progressive cerebellar ataxia (HP:0002073)3.96943299
8Annular pancreas (HP:0001734)3.86082862
9Febrile seizures (HP:0002373)3.81179129
10Action tremor (HP:0002345)3.77749726
11Ankle clonus (HP:0011448)3.70673530
12Absence seizures (HP:0002121)3.55371892
13Impaired vibration sensation in the lower limbs (HP:0002166)3.44567301
14Urinary urgency (HP:0000012)3.44277844
15Gaze-evoked nystagmus (HP:0000640)3.44139835
16Dysmetria (HP:0001310)3.23886608
17Limb dystonia (HP:0002451)3.22881959
18Neurofibrillary tangles (HP:0002185)3.22826281
19Impaired smooth pursuit (HP:0007772)3.21808213
20Poor eye contact (HP:0000817)3.20198602
21Dialeptic seizures (HP:0011146)3.18446934
22Dysmetric saccades (HP:0000641)3.18013656
23Generalized tonic-clonic seizures (HP:0002069)3.14340024
24Papilledema (HP:0001085)3.14111982
25Hemiplegia (HP:0002301)3.13677754
26Pointed chin (HP:0000307)3.13049673
27Abnormality of the lower motor neuron (HP:0002366)3.07412813
28Supranuclear gaze palsy (HP:0000605)3.06897671
29Sleep apnea (HP:0010535)3.06380866
30Depression (HP:0000716)3.06030619
31Hand muscle atrophy (HP:0009130)3.05067677
32Diplopia (HP:0000651)3.02341997
33Abnormality of binocular vision (HP:0011514)3.02341997
34Dysdiadochokinesis (HP:0002075)2.99217095
35Urinary bladder sphincter dysfunction (HP:0002839)2.98446159
36Broad-based gait (HP:0002136)2.96370049
37Genetic anticipation (HP:0003743)2.96283814
38Impaired social interactions (HP:0000735)2.94131706
39Abnormal social behavior (HP:0012433)2.94131706
40Spastic gait (HP:0002064)2.80715202
41Truncal ataxia (HP:0002078)2.80091569
42Peripheral hypomyelination (HP:0007182)2.77756542
43Stereotypic behavior (HP:0000733)2.76539489
44Abnormality of ocular smooth pursuit (HP:0000617)2.74600814
45Torticollis (HP:0000473)2.71324250
46Scanning speech (HP:0002168)2.71304115
47Amyotrophic lateral sclerosis (HP:0007354)2.69303442
48Abnormality of oral frenula (HP:0000190)2.64874168
49Abnormal eating behavior (HP:0100738)2.64177805
50Ventricular fibrillation (HP:0001663)2.63369477
51Amblyopia (HP:0000646)2.62922029
52Akinesia (HP:0002304)2.61381143
53Mutism (HP:0002300)2.61263136
54Postural instability (HP:0002172)2.58476594
55Ankyloglossia (HP:0010296)2.50570656
56Anxiety (HP:0000739)2.49538894
57Focal dystonia (HP:0004373)2.46272591
58Growth hormone excess (HP:0000845)2.41011098
59Lower limb amyotrophy (HP:0007210)2.34589438
60Foot dorsiflexor weakness (HP:0009027)2.26487559
61Hyperactive renin-angiotensin system (HP:0000841)2.25220401
62Bundle branch block (HP:0011710)2.24827066
63Intention tremor (HP:0002080)2.22734870
64Rigidity (HP:0002063)2.20218400
65Craniofacial dystonia (HP:0012179)2.19601089
66Status epilepticus (HP:0002133)2.19231520
67Resting tremor (HP:0002322)2.16432148
68Bradykinesia (HP:0002067)2.15535244
69Abnormality of the foot musculature (HP:0001436)2.14562811
70Mildly elevated creatine phosphokinase (HP:0008180)2.09555938
71Hammertoe (HP:0001765)2.09295247
72Upper limb amyotrophy (HP:0009129)2.08393993
73Distal upper limb amyotrophy (HP:0007149)2.08393993
74Abnormal gallbladder physiology (HP:0012438)2.07514775
75Cholecystitis (HP:0001082)2.07514775
76Impaired vibratory sensation (HP:0002495)2.06908524
77Deep palmar crease (HP:0006191)2.04074614
78Bronchomalacia (HP:0002780)2.04069308
79Sudden death (HP:0001699)2.03379498
80Segmental peripheral demyelination/remyelination (HP:0003481)2.03272005
81Tetraplegia (HP:0002445)2.03099128
82Shallow orbits (HP:0000586)2.02713460
83Cerebral hypomyelination (HP:0006808)2.01046800
84Megalencephaly (HP:0001355)1.99163826
85Spinal canal stenosis (HP:0003416)1.97467663
86Progressive inability to walk (HP:0002505)1.96172067
87Incomplete penetrance (HP:0003829)1.93729714
88Obstructive sleep apnea (HP:0002870)1.93244668
89Dyskinesia (HP:0100660)1.92141802
90Abnormality of the corticospinal tract (HP:0002492)1.91230792
91Neuronal loss in central nervous system (HP:0002529)1.91101556
92Insomnia (HP:0100785)1.90161197
93Abnormality of saccadic eye movements (HP:0000570)1.90051115
94Lower limb muscle weakness (HP:0007340)1.89761682
95Delusions (HP:0000746)1.88515188
96Hemiparesis (HP:0001269)1.88397119
97Overriding aorta (HP:0002623)1.86854769
98Hypoventilation (HP:0002791)1.85870323
99Clonus (HP:0002169)1.85801170
100Syncope (HP:0001279)1.85756977
101Apathy (HP:0000741)1.85102964
102Neoplasm of the heart (HP:0100544)1.81181649
103Polyphagia (HP:0002591)1.79445533
104Abnormal atrioventricular conduction (HP:0005150)1.78620980
105Heart block (HP:0012722)1.76787282
106Termporal pattern (HP:0011008)1.75390606
107Insidious onset (HP:0003587)1.75390606
108Asymmetric growth (HP:0100555)1.74627809
109Gait ataxia (HP:0002066)1.74460950
110Diminished motivation (HP:0000745)1.74004506
111Iris hypopigmentation (HP:0007730)1.73777694
112Cerebral inclusion bodies (HP:0100314)1.73632104
113Achilles tendon contracture (HP:0001771)1.72869220
114Lower limb asymmetry (HP:0100559)1.72815020
115Stomatitis (HP:0010280)1.72783482
116Distal sensory impairment (HP:0002936)1.71702301
117Fetal akinesia sequence (HP:0001989)1.68209916
118Slow progression (HP:0003677)1.67126168
119Intellectual disability, profound (HP:0002187)1.66752756
120Distal lower limb amyotrophy (HP:0008944)1.66670420
121Muscle stiffness (HP:0003552)1.66470355
122Limb ataxia (HP:0002070)1.66332131
123Abnormality of the musculature of the hand (HP:0001421)1.66252811
124Hyperacusis (HP:0010780)1.65722386
125Rapidly progressive (HP:0003678)1.65599137
126Ocular albinism (HP:0001107)1.64760424
127Right ventricular cardiomyopathy (HP:0011663)1.64315265
128Ventricular arrhythmia (HP:0004308)1.63614764
129Truncus arteriosus (HP:0001660)1.62447414
130Hypercortisolism (HP:0001578)1.61613139
131Vertebral arch anomaly (HP:0008438)1.60229770
132Neuroendocrine neoplasm (HP:0100634)1.60215663
133Abnormal EKG (HP:0003115)1.60022905
134Neoplasm of the peripheral nervous system (HP:0100007)1.59491407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.66231113
2MAP3K94.19367459
3NTRK34.17685503
4MAP3K123.06001594
5KSR22.84648623
6ERN12.83406221
7DAPK22.78286195
8PAK62.55678241
9MINK12.46351903
10PRKD32.37854694
11MST1R2.37490846
12CAMKK12.35726638
13TAOK12.22339253
14DAPK12.16651979
15RIPK42.06802556
16TESK21.98779733
17MAP3K41.89201833
18ARAF1.83599692
19CDK191.75558470
20CAMKK21.74158734
21STK381.69398992
22RAF11.61886199
23NTRK11.57280365
24KSR11.56330024
25SIK11.52663972
26PRKG21.51559114
27TESK11.47392507
28NTRK21.45469133
29TYRO31.45285704
30MAP2K71.44858305
31MAP3K131.40874445
32CDK51.37293343
33FES1.35982704
34MET1.33527245
35MAP3K21.25192304
36SIK21.23191958
37PHKG21.22812879
38PHKG11.22812879
39PRPF4B1.20235008
40ALK1.18346298
41RIPK11.16291992
42ICK1.12600360
43TNK21.10227009
44MARK11.09141094
45LIMK11.02911015
46PRKCH1.02739608
47MAP2K41.02607435
48CDK181.01940714
49CDK150.99723296
50PRKCG0.98656193
51CAMK10.95344112
52DAPK30.93939106
53CDK140.93555721
54CDK11A0.90420433
55TNIK0.89259578
56STK110.88783950
57LATS20.84825005
58NEK60.83937523
59BRSK10.83013995
60PTK2B0.82933115
61SMG10.79933001
62CASK0.79366763
63SIK30.77285830
64PLK20.76195956
65MAP3K10.75031430
66PDGFRA0.74339197
67PNCK0.73467514
68CAMK2B0.73441732
69PDK10.73364253
70MAPK120.71328125
71UHMK10.71284973
72NEK10.70035411
73DMPK0.69921579
74GRK50.69296412
75PKN20.68038113
76RET0.67170664
77EPHB10.66791417
78MARK20.64915719
79PTK60.63444401
80SCYL20.63307822
81CAMK2A0.62644953
82RPS6KA40.60069891
83PDPK10.59674414
84RPS6KA20.57061265
85FYN0.55483510
86PRKD20.55183037
87FGFR40.53854542
88MAP4K10.53843459
89EPHB20.53403823
90MAP3K100.52346370
91PTK20.51222816
92CDC42BPA0.50596854
93BMX0.49600559
94ZAP700.49313133
95MAPK130.47293430
96PAK30.46725248
97SGK30.46661767
98TRIB30.43191288
99WNK10.42740171
100CAMK2G0.42626699
101FGFR10.42334868
102MAP2K10.41834855
103EEF2K0.41771721
104TRIM280.41591810
105ROCK20.39962045
106SGK10.39924693
107PRKCZ0.39836332
108MAP3K70.38612117
109KDR0.38440751
110EPHA20.37496571
111TAOK20.37311608
112MAPK100.37142194
113CAMK40.36670332
114DYRK1A0.36515415
115DDR20.36229330
116MAP3K110.36198508
117OXSR10.34290943
118MAP2K60.34150189
119BRAF0.33830714
120PRKCI0.33380393
121GRK60.33218517
122RPS6KA30.33182181
123TXK0.32176030
124CAMK2D0.32155510
125HCK0.31903438
126BMPR20.31464600
127SRC0.30080024
128SGK2230.29557497
129SGK4940.29557497
130LMTK20.29181939

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.04740632
2Nicotine addiction_Homo sapiens_hsa050332.94098472
3Olfactory transduction_Homo sapiens_hsa047402.79912576
4Long-term potentiation_Homo sapiens_hsa047202.64604576
5Circadian entrainment_Homo sapiens_hsa047132.30597186
6Amphetamine addiction_Homo sapiens_hsa050312.25504877
7Glutamatergic synapse_Homo sapiens_hsa047242.16242287
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15705804
9Morphine addiction_Homo sapiens_hsa050322.13170962
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12753939
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.11491336
12GABAergic synapse_Homo sapiens_hsa047272.05899311
13Salivary secretion_Homo sapiens_hsa049702.01793000
14Dopaminergic synapse_Homo sapiens_hsa047281.93257302
15Gastric acid secretion_Homo sapiens_hsa049711.81714724
16Cholinergic synapse_Homo sapiens_hsa047251.72457749
17Oxytocin signaling pathway_Homo sapiens_hsa049211.62410728
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61468799
19Insulin secretion_Homo sapiens_hsa049111.59644320
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53293306
21Cocaine addiction_Homo sapiens_hsa050301.46860717
22Long-term depression_Homo sapiens_hsa047301.45700048
23GnRH signaling pathway_Homo sapiens_hsa049121.38272772
24Renin secretion_Homo sapiens_hsa049241.32933566
25Calcium signaling pathway_Homo sapiens_hsa040201.31717084
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29973058
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29516971
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29240720
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27167436
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26670730
31Gap junction_Homo sapiens_hsa045401.26268908
32Taste transduction_Homo sapiens_hsa047421.25316075
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23755780
34Glioma_Homo sapiens_hsa052141.21730958
35cAMP signaling pathway_Homo sapiens_hsa040241.16271003
36VEGF signaling pathway_Homo sapiens_hsa043701.16004854
37Estrogen signaling pathway_Homo sapiens_hsa049151.14705871
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13802961
39Serotonergic synapse_Homo sapiens_hsa047261.13624302
40Oocyte meiosis_Homo sapiens_hsa041141.08681734
41Collecting duct acid secretion_Homo sapiens_hsa049661.06861550
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06181953
43T cell receptor signaling pathway_Homo sapiens_hsa046601.04180504
44ErbB signaling pathway_Homo sapiens_hsa040120.99319533
45Fructose and mannose metabolism_Homo sapiens_hsa000510.96634066
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96470786
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94155328
48Type II diabetes mellitus_Homo sapiens_hsa049300.93534810
49Bile secretion_Homo sapiens_hsa049760.93092653
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.92828344
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92180453
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.91407226
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91007612
54Melanogenesis_Homo sapiens_hsa049160.89555255
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89048859
56Axon guidance_Homo sapiens_hsa043600.85716494
57Endocytosis_Homo sapiens_hsa041440.85229150
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.84174120
59MAPK signaling pathway_Homo sapiens_hsa040100.83428355
60Rap1 signaling pathway_Homo sapiens_hsa040150.83146315
61Chemokine signaling pathway_Homo sapiens_hsa040620.83005602
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81639228
63Vitamin B6 metabolism_Homo sapiens_hsa007500.79062507
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78979329
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77536568
66Choline metabolism in cancer_Homo sapiens_hsa052310.76652743
67Vibrio cholerae infection_Homo sapiens_hsa051100.75921409
68Thyroid hormone synthesis_Homo sapiens_hsa049180.74980007
69Type I diabetes mellitus_Homo sapiens_hsa049400.73821164
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73512268
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73120344
72Pancreatic secretion_Homo sapiens_hsa049720.73100896
73Non-small cell lung cancer_Homo sapiens_hsa052230.71948263
74Dorso-ventral axis formation_Homo sapiens_hsa043200.71010953
75Prion diseases_Homo sapiens_hsa050200.70597924
76mTOR signaling pathway_Homo sapiens_hsa041500.69610722
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.69189262
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67179751
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66924421
80Inositol phosphate metabolism_Homo sapiens_hsa005620.66192480
81Arginine biosynthesis_Homo sapiens_hsa002200.65842147
82Dilated cardiomyopathy_Homo sapiens_hsa054140.64489038
83Tight junction_Homo sapiens_hsa045300.62896835
84Mineral absorption_Homo sapiens_hsa049780.60200351
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59901208
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59467909
87Salmonella infection_Homo sapiens_hsa051320.59321359
88Endometrial cancer_Homo sapiens_hsa052130.58839243
89Shigellosis_Homo sapiens_hsa051310.58815441
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58652242
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58053642
92Ras signaling pathway_Homo sapiens_hsa040140.57872089
93Colorectal cancer_Homo sapiens_hsa052100.57483574
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56110921
95Renal cell carcinoma_Homo sapiens_hsa052110.55907214
96Graft-versus-host disease_Homo sapiens_hsa053320.55402821
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55341972
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55033166
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54441345
100Primary immunodeficiency_Homo sapiens_hsa053400.53122657
101Protein digestion and absorption_Homo sapiens_hsa049740.52024753
102Platelet activation_Homo sapiens_hsa046110.51312883
103Insulin signaling pathway_Homo sapiens_hsa049100.50905481
104Thyroid cancer_Homo sapiens_hsa052160.50895756
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50646959
106Cardiac muscle contraction_Homo sapiens_hsa042600.50018962
107Folate biosynthesis_Homo sapiens_hsa007900.49668832
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49598637
109Notch signaling pathway_Homo sapiens_hsa043300.48742073
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48183891
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.47466512
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45952415
113B cell receptor signaling pathway_Homo sapiens_hsa046620.44854641
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44144118
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.42949049
116Sulfur relay system_Homo sapiens_hsa041220.42909163
117Wnt signaling pathway_Homo sapiens_hsa043100.41758173
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41667062
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40730037
120Asthma_Homo sapiens_hsa053100.39718409
121Arginine and proline metabolism_Homo sapiens_hsa003300.38936388
122Prolactin signaling pathway_Homo sapiens_hsa049170.38924055
123Bladder cancer_Homo sapiens_hsa052190.38847842
124Pancreatic cancer_Homo sapiens_hsa052120.38631580
125Glucagon signaling pathway_Homo sapiens_hsa049220.37651540
126Circadian rhythm_Homo sapiens_hsa047100.31489656

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