LPGAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)4.45590741
2L-phenylalanine catabolic process (GO:0006559)4.32135920
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.32135920
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.15313381
5alpha-linolenic acid metabolic process (GO:0036109)4.10181421
6L-phenylalanine metabolic process (GO:0006558)3.97797041
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.97797041
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.96916640
9negative regulation of complement activation (GO:0045916)3.73345797
10positive regulation by symbiont of host defense response (GO:0052509)3.65038767
11modulation by symbiont of host defense response (GO:0052031)3.65038767
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.65038767
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.65038767
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.65038767
15modulation by symbiont of host immune response (GO:0052553)3.65038767
16detection of external biotic stimulus (GO:0098581)3.60125650
17positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.58703426
18aromatic amino acid family catabolic process (GO:0009074)3.52630020
19detection of other organism (GO:0098543)3.52584414
20macrophage activation involved in immune response (GO:0002281)3.51790823
21regulation of triglyceride catabolic process (GO:0010896)3.50398197
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46057100
23complement activation, alternative pathway (GO:0006957)3.39559033
24regulation of interferon-beta biosynthetic process (GO:0045357)3.39525435
25urea cycle (GO:0000050)3.37386641
26urea metabolic process (GO:0019627)3.37386641
27very-low-density lipoprotein particle assembly (GO:0034379)3.34081008
28acylglycerol catabolic process (GO:0046464)3.32943516
29neutral lipid catabolic process (GO:0046461)3.32943516
30negative regulation of cell killing (GO:0031342)3.31641025
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.31641025
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.31531462
33negative regulation of humoral immune response (GO:0002921)3.28574742
34antigen processing and presentation of endogenous antigen (GO:0019883)3.27963805
35positive regulation of fatty acid beta-oxidation (GO:0032000)3.27842400
36bile acid biosynthetic process (GO:0006699)3.25745555
37positive regulation of lipid catabolic process (GO:0050996)3.25329362
38cellular response to ethanol (GO:0071361)3.24372402
39triglyceride catabolic process (GO:0019433)3.22176136
40dicarboxylic acid biosynthetic process (GO:0043650)3.21824506
41triglyceride homeostasis (GO:0070328)3.21603609
42acylglycerol homeostasis (GO:0055090)3.21603609
43plasma lipoprotein particle clearance (GO:0034381)3.20562696
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.19690461
45macroautophagy (GO:0016236)3.18872960
46low-density lipoprotein particle clearance (GO:0034383)3.15432830
47high-density lipoprotein particle remodeling (GO:0034375)3.13401574
48glutamate metabolic process (GO:0006536)3.13107567
49microglial cell activation (GO:0001774)3.10651871
50regulation of protein activation cascade (GO:2000257)3.09172024
51macrophage activation (GO:0042116)3.08087043
52nitrogen cycle metabolic process (GO:0071941)3.06687997
53kynurenine metabolic process (GO:0070189)3.04246838
54lysine catabolic process (GO:0006554)3.04240538
55lysine metabolic process (GO:0006553)3.04240538
56detection of bacterium (GO:0016045)3.03656184
57positive regulation of gamma-delta T cell activation (GO:0046645)3.01358002
58lipoprotein transport (GO:0042953)3.00974213
59detection of biotic stimulus (GO:0009595)2.97965224
60reverse cholesterol transport (GO:0043691)2.97191938
61antigen processing and presentation via MHC class Ib (GO:0002475)2.96759612
62cysteine metabolic process (GO:0006534)2.96388970
63bile acid metabolic process (GO:0008206)2.96250370
64cellular ketone body metabolic process (GO:0046950)2.95596841
65cellular extravasation (GO:0045123)2.94787882
66positive regulation of fatty acid oxidation (GO:0046321)2.94330649
67sulfur amino acid catabolic process (GO:0000098)2.93580265
68negative regulation of fibrinolysis (GO:0051918)2.92184584
69glyoxylate metabolic process (GO:0046487)2.91497047
70regulation of complement activation (GO:0030449)2.91414049
71regulation of short-term neuronal synaptic plasticity (GO:0048172)2.90840836
72glutamate secretion (GO:0014047)2.90645029
73production of molecular mediator involved in inflammatory response (GO:0002532)2.89035883
74synaptic vesicle maturation (GO:0016188)2.88890221
75hormone catabolic process (GO:0042447)2.88281721
76positive regulation of cellular amide metabolic process (GO:0034250)2.86373520
77plasma lipoprotein particle remodeling (GO:0034369)2.86156604
78protein-lipid complex remodeling (GO:0034368)2.86156604
79macromolecular complex remodeling (GO:0034367)2.86156604
80plasma lipoprotein particle assembly (GO:0034377)2.84487494
81tryptophan catabolic process (GO:0006569)2.84444344
82indole-containing compound catabolic process (GO:0042436)2.84444344
83indolalkylamine catabolic process (GO:0046218)2.84444344
84drug catabolic process (GO:0042737)2.84360105
85neutrophil activation involved in immune response (GO:0002283)2.82310810
86fatty acid transmembrane transport (GO:1902001)2.79601986
87acetyl-CoA metabolic process (GO:0006084)2.78173417
88positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.77900012
89regulation of fatty acid beta-oxidation (GO:0031998)2.77241292
90cellular glucuronidation (GO:0052695)2.77240858
91phospholipid homeostasis (GO:0055091)2.77019968
92protein carboxylation (GO:0018214)2.76771964
93peptidyl-glutamic acid carboxylation (GO:0017187)2.76771964
94angiotensin maturation (GO:0002003)2.75541453
95locomotory exploration behavior (GO:0035641)2.75096386
96regulation of fibrinolysis (GO:0051917)2.73536423
97tyrosine metabolic process (GO:0006570)2.71233689
98cholesterol efflux (GO:0033344)2.71091851
99gamma-aminobutyric acid transport (GO:0015812)2.69747012
100regulation of cholesterol homeostasis (GO:2000188)2.69718229
101positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.69590790
102regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.68975282
103regulation of cholesterol esterification (GO:0010872)2.68965865
104negative regulation of lipase activity (GO:0060192)2.68740694
105fatty acid beta-oxidation (GO:0006635)2.68479472
106phospholipid efflux (GO:0033700)2.68474591
107regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.68259982
108short-chain fatty acid metabolic process (GO:0046459)2.66736283
109positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.66474686
110regulation of sequestering of triglyceride (GO:0010889)2.65083839
1112-oxoglutarate metabolic process (GO:0006103)2.64543191
112vocalization behavior (GO:0071625)2.64539976
113glycerolipid catabolic process (GO:0046503)2.63168790
114maintenance of gastrointestinal epithelium (GO:0030277)2.63148979
115response to host immune response (GO:0052572)2.63035773
116response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.63035773
117intestinal absorption (GO:0050892)2.62865665
118synaptic vesicle exocytosis (GO:0016079)2.62286842
119tryptophan metabolic process (GO:0006568)2.62126433
120fatty acid oxidation (GO:0019395)2.61607650
121regulation of B cell receptor signaling pathway (GO:0050855)2.61268284
122protein-lipid complex assembly (GO:0065005)2.61069721
123bile acid and bile salt transport (GO:0015721)2.58836933
124positive regulation of fatty acid metabolic process (GO:0045923)2.58505862
125fatty acid catabolic process (GO:0009062)2.58454820
126response to host (GO:0075136)2.58106591
127response to host defenses (GO:0052200)2.58106591
128response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.58106591
129dicarboxylic acid catabolic process (GO:0043649)2.56973069
130fatty acid homeostasis (GO:0055089)2.56698549
131fatty-acyl-CoA biosynthetic process (GO:0046949)2.56388693
132lipid oxidation (GO:0034440)2.56086579
133alanine transport (GO:0032328)2.55785625
134epoxygenase P450 pathway (GO:0019373)2.55132159
135triglyceride metabolic process (GO:0006641)2.55047697
136aspartate family amino acid catabolic process (GO:0009068)2.54956523
137alpha-amino acid catabolic process (GO:1901606)2.54642196
138amino-acid betaine metabolic process (GO:0006577)2.54288693
139coenzyme catabolic process (GO:0009109)2.53683972
140ketone body metabolic process (GO:1902224)2.52408545
141phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.52319382
142nucleobase catabolic process (GO:0046113)2.52271635
143monocarboxylic acid catabolic process (GO:0072329)2.51837682
144exogenous drug catabolic process (GO:0042738)2.51215961
145neurotransmitter secretion (GO:0007269)2.50987865
146homocysteine metabolic process (GO:0050667)2.50699649
147negative regulation of protein activation cascade (GO:2000258)2.48443092
148triglyceride biosynthetic process (GO:0019432)2.48115308
149regulation of cellular amide metabolic process (GO:0034248)2.47249757
150negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.47231188
151acylglycerol metabolic process (GO:0006639)2.47114987
152acyl-CoA biosynthetic process (GO:0071616)2.46847434
153thioester biosynthetic process (GO:0035384)2.46847434
154regulation of bile acid biosynthetic process (GO:0070857)2.46739999
155neutral lipid metabolic process (GO:0006638)2.45957470
156iron ion import (GO:0097286)2.43882660
157uronic acid metabolic process (GO:0006063)2.42980691
158glucuronate metabolic process (GO:0019585)2.42980691
159I-kappaB phosphorylation (GO:0007252)2.39855736
160B cell receptor signaling pathway (GO:0050853)2.39249217
161negative regulation of lymphocyte mediated immunity (GO:0002707)2.37804319
162response to peptidoglycan (GO:0032494)2.37404021
163COPII vesicle coating (GO:0048208)2.37111119
164embryonic process involved in female pregnancy (GO:0060136)2.36829757
165nerve growth factor signaling pathway (GO:0038180)2.36061837
166negative regulation of fatty acid transport (GO:2000192)2.33242949
167leukocyte migration involved in inflammatory response (GO:0002523)2.29139260
168regulation of gamma-delta T cell activation (GO:0046643)2.28119516
169positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.28086144
170mRNA modification (GO:0016556)2.26409368
171regulation of humoral immune response (GO:0002920)2.25480294
172regulation of beta-amyloid formation (GO:1902003)2.24180768
173negative regulation of B cell mediated immunity (GO:0002713)2.22132919
174negative regulation of immunoglobulin mediated immune response (GO:0002890)2.22132919
175response to interleukin-15 (GO:0070672)2.21428556
176positive regulation of interferon-alpha production (GO:0032727)2.19950494
177neutrophil activation (GO:0042119)2.18686328
178phospholipid dephosphorylation (GO:0046839)2.17275302
179regulation of ARF protein signal transduction (GO:0032012)2.17223969
180early endosome to late endosome transport (GO:0045022)2.15858366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.64949955
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.64370988
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48922515
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.44667627
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.05073197
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.04389578
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.00750508
8GATA1_22025678_ChIP-Seq_K562_Human3.00351696
9EZH2_22144423_ChIP-Seq_EOC_Human2.95127239
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.77425047
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.51033075
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.45582219
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.31626912
14GBX2_23144817_ChIP-Seq_PC3_Human2.30370326
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.23017517
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22253765
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21747356
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.19195187
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11371870
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03347753
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03269910
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00468700
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98897899
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.98211719
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93178790
26DROSHA_22980978_ChIP-Seq_HELA_Human1.92527245
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.89018376
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83818856
29* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80732135
30* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80732135
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78552865
32* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73634847
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70061322
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64710078
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64623057
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63188776
37* FOXO3_23340844_ChIP-Seq_DLD1_Human1.62969488
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.62441305
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.62288989
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58244723
41FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56950761
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56688997
43* RARB_27405468_Chip-Seq_BRAIN_Mouse1.53214428
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51541300
45TAF15_26573619_Chip-Seq_HEK293_Human1.51126429
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51039228
47REST_21632747_ChIP-Seq_MESCs_Mouse1.49357211
48RUNX_20019798_ChIP-Seq_JUKART_Human1.49349323
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49164714
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.45149725
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42179966
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.40562354
53* VDR_24787735_ChIP-Seq_THP-1_Human1.39803528
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39721628
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37484819
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36827599
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36143785
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36065622
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35383158
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35287210
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.34883537
62* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33470849
63FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32757693
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.31157797
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.30859800
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29666792
67CLOCK_20551151_ChIP-Seq_293T_Human1.29300027
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27433485
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27294215
70SPI1_23127762_ChIP-Seq_K562_Human1.26763946
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.26407101
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25854087
73AR_21572438_ChIP-Seq_LNCaP_Human1.24680778
74CDX2_20551321_ChIP-Seq_CACO-2_Human1.24647359
75* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24226964
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22945666
77SMAD4_21799915_ChIP-Seq_A2780_Human1.22907413
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21772522
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20782671
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.20433107
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19974329
82SOX2_20726797_ChIP-Seq_SW620_Human1.19621201
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19257119
84* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17757747
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16866335
86RNF2_27304074_Chip-Seq_ESCs_Mouse1.16814954
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.16482853
88* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15418834
89* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15376797
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.14987243
91CJUN_26792858_Chip-Seq_BT549_Human1.14510598
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14147494
93* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13673617
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12734795
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12319650
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12319650
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12203279
98* TP63_23658742_ChIP-Seq_EP156T_Human1.11785226
99FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10925838
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.10798343
101* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09461861
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09378862
103* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08284509
104TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.07923060
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07876794
106PU_27001747_Chip-Seq_BMDM_Mouse1.06659500
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05568152
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05049448
109BCAT_22108803_ChIP-Seq_LS180_Human1.05047380
110* STAT3_23295773_ChIP-Seq_U87_Human1.04964749
111GATA4_25053715_ChIP-Seq_YYC3_Human1.04882314
112* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03883090
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03048941
114* GATA2_19941826_ChIP-Seq_K562_Human1.02844220
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02751282
116IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02014627
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01925646
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01925646
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01885182
120* CMYC_18555785_Chip-Seq_ESCs_Mouse1.01549899
121* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01452768
122* EZH2_27294783_Chip-Seq_NPCs_Mouse1.00572298
123AHR_22903824_ChIP-Seq_MCF-7_Human1.00426788
124AR_25329375_ChIP-Seq_VCAP_Human0.99779345
125* E2F1_18555785_Chip-Seq_ESCs_Mouse0.99595289
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99368582
127AR_19668381_ChIP-Seq_PC3_Human0.99173196
128GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98941953
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98063411
130* NANOG_18555785_Chip-Seq_ESCs_Mouse0.97478289
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.97432985
132CDX2_22108803_ChIP-Seq_LS180_Human0.96855621
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.96544177
134TP53_16413492_ChIP-PET_HCT116_Human0.96381740
135* NFE2_27457419_Chip-Seq_LIVER_Mouse0.96349568
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.96287516
137TRIM28_21343339_ChIP-Seq_HEK293_Human0.95727434
138SMAD3_21741376_ChIP-Seq_EPCs_Human0.95160241
139* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93673170
140* P53_22387025_ChIP-Seq_ESCs_Mouse0.93325999
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92530144
142* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92064051
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92004740
144P300_19829295_ChIP-Seq_ESCs_Human0.91122320
145RXR_22108803_ChIP-Seq_LS180_Human0.90501956
146* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90372445
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89945556
148* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89931453
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89552890
150* GATA6_25053715_ChIP-Seq_YYC3_Human0.88011760
151CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87879369
152THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87571825
153ZNF274_21170338_ChIP-Seq_K562_Hela0.87144613
154TCF4_23295773_ChIP-Seq_U87_Human0.85050215
155* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84432428
156* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84277094
157DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83589746
158TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81307661
159HTT_18923047_ChIP-ChIP_STHdh_Human0.80606215
160SMAD4_21741376_ChIP-Seq_EPCs_Human0.80561103
161* HNF4A_19822575_ChIP-Seq_HepG2_Human0.80193684
162* KDM2B_26808549_Chip-Seq_K562_Human0.80077664
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.79550609
164WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79075600
165* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78973222
166POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77357410
167UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.76616804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.12357196
2MP0002139_abnormal_hepatobiliary_system4.98514076
3MP0005085_abnormal_gallbladder_physiolo3.75213831
4MP0005365_abnormal_bile_salt3.70260812
5MP0000569_abnormal_digit_pigmentation3.53086903
6MP0004859_abnormal_synaptic_plasticity3.27139371
7MP0008875_abnormal_xenobiotic_pharmacok3.20171963
8MP0010329_abnormal_lipoprotein_level3.09078194
9MP0003724_increased_susceptibility_to3.07355749
10MP0003300_gastrointestinal_ulcer2.97030244
11MP0003183_abnormal_peptide_metabolism2.75624394
12MP0005409_darkened_coat_color2.59380888
13MP0003252_abnormal_bile_duct2.57227662
14MP0002837_dystrophic_cardiac_calcinosis2.34361353
15MP0002166_altered_tumor_susceptibility2.20219140
16MP0009780_abnormal_chondrocyte_physiolo2.18650307
17MP0004130_abnormal_muscle_cell2.16038257
18MP0004270_analgesia2.16028369
19MP0003635_abnormal_synaptic_transmissio2.12163772
20MP0001835_abnormal_antigen_presentation2.05113523
21MP0000015_abnormal_ear_pigmentation2.05057742
22MP0005670_abnormal_white_adipose2.03688811
23MP0001666_abnormal_nutrient_absorption1.94299512
24MP0002118_abnormal_lipid_homeostasis1.93379409
25MP0010352_gastrointestinal_tract_polyps1.92063871
26MP0003303_peritoneal_inflammation1.91961053
27MP0002009_preneoplasia1.91440038
28MP0005451_abnormal_body_composition1.91436241
29MP0005408_hypopigmentation1.90231291
30MP0002877_abnormal_melanocyte_morpholog1.90204323
31MP0003880_abnormal_central_pattern1.89467305
32MP0002876_abnormal_thyroid_physiology1.88758577
33MP0003172_abnormal_lysosome_physiology1.83031236
34MP0003329_amyloid_beta_deposits1.82157369
35MP0002909_abnormal_adrenal_gland1.80698101
36MP0000013_abnormal_adipose_tissue1.77807830
37MP0003436_decreased_susceptibility_to1.77169974
38MP0001501_abnormal_sleep_pattern1.76350839
39MP0003690_abnormal_glial_cell1.75287251
40MP0009046_muscle_twitch1.74787989
41MP0003191_abnormal_cellular_cholesterol1.74314416
42MP0005332_abnormal_amino_acid1.72478038
43MP0002822_catalepsy1.72248606
44MP0009745_abnormal_behavioral_response1.71871226
45MP0002064_seizures1.67647794
46MP0009840_abnormal_foam_cell1.63892710
47MP0002063_abnormal_learning/memory/cond1.62491445
48MP0005666_abnormal_adipose_tissue1.61004436
49MP0005083_abnormal_biliary_tract1.59509614
50MP0002419_abnormal_innate_immunity1.58810224
51MP0002138_abnormal_hepatobiliary_system1.57096047
52MP0005174_abnormal_tail_pigmentation1.49440973
53MP0005535_abnormal_body_temperature1.48043252
54MP0003195_calcinosis1.47054496
55MP0009785_altered_susceptibility_to1.46837055
56MP0008260_abnormal_autophagy1.46755548
57MP0005464_abnormal_platelet_physiology1.46136350
58MP0003828_pulmonary_edema1.45994654
59MP0000604_amyloidosis1.42693071
60MP0005058_abnormal_lysosome_morphology1.41007616
61MP0000685_abnormal_immune_system1.40969672
62MP0006082_CNS_inflammation1.40511630
63MP0001851_eye_inflammation1.39122798
64MP0004883_abnormal_blood_vessel1.37795691
65MP0002971_abnormal_brown_adipose1.37677520
66MP0003091_abnormal_cell_migration1.36734544
67MP0000371_diluted_coat_color1.36139251
68MP0001486_abnormal_startle_reflex1.35824879
69MP0002272_abnormal_nervous_system1.35002302
70MP0002006_tumorigenesis1.33698562
71MP0005375_adipose_tissue_phenotype1.33694105
72MP0010155_abnormal_intestine_physiology1.33568073
73MP0000609_abnormal_liver_physiology1.30691622
74MP0002572_abnormal_emotion/affect_behav1.29661478
75MP0005164_abnormal_response_to1.28675031
76MP0005584_abnormal_enzyme/coenzyme_acti1.27259928
77MP0004484_altered_response_of1.27104449
78MP0003806_abnormal_nucleotide_metabolis1.25883385
79MP0005025_abnormal_response_to1.25733237
80MP0004185_abnormal_adipocyte_glucose1.23126653
81MP0000003_abnormal_adipose_tissue1.22498362
82MP0004019_abnormal_vitamin_homeostasis1.21588934
83MP0010234_abnormal_vibrissa_follicle1.21053893
84MP0001800_abnormal_humoral_immune1.19912242
85MP0003705_abnormal_hypodermis_morpholog1.18660859
86MP0002734_abnormal_mechanical_nocicepti1.15251494
87MP0004264_abnormal_extraembryonic_tissu1.14662691
88MP0003656_abnormal_erythrocyte_physiolo1.14426958
89MP0005334_abnormal_fat_pad1.14328425
90MP0003866_abnormal_defecation1.14126426
91MP0004924_abnormal_behavior1.12957399
92MP0005386_behavior/neurological_phenoty1.12957399
93MP0005448_abnormal_energy_balance1.11968646
94MP0004043_abnormal_pH_regulation1.11546504
95MP0002396_abnormal_hematopoietic_system1.11097246
96MP0001440_abnormal_grooming_behavior1.10964611
97MP0001533_abnormal_skeleton_physiology1.10512557
98MP0002078_abnormal_glucose_homeostasis1.07909890
99MP0003633_abnormal_nervous_system1.06421529
100MP0001968_abnormal_touch/_nociception1.04807422
101MP0005166_decreased_susceptibility_to1.04505236
102MP0001845_abnormal_inflammatory_respons1.02188613
103MP0005387_immune_system_phenotype1.01686365
104MP0001790_abnormal_immune_system1.01686365
105MP0008569_lethality_at_weaning1.01081879
106MP0001177_atelectasis1.00340716
107MP0005000_abnormal_immune_tolerance1.00336402
108MP0008469_abnormal_protein_level0.99755087
109MP0002723_abnormal_immune_serum0.99407455
110MP0003868_abnormal_feces_composition0.98877887
111MP0008057_abnormal_DNA_replication0.98038819
112MP0002452_abnormal_antigen_presenting0.97448823
113MP0005248_abnormal_Harderian_gland0.97248898
114MP0000465_gastrointestinal_hemorrhage0.96789784
115MP0005319_abnormal_enzyme/_coenzyme0.93982402
116MP0008874_decreased_physiological_sensi0.92207691
117MP0002067_abnormal_sensory_capabilities0.92041391
118MP0000751_myopathy0.91534913
119MP0000372_irregular_coat_pigmentation0.91516105
120MP0002998_abnormal_bone_remodeling0.90691759
121MP0008961_abnormal_basal_metabolism0.89895617
122MP0005075_abnormal_melanosome_morpholog0.89772493
123MP0002733_abnormal_thermal_nociception0.88998520
124MP0002420_abnormal_adaptive_immunity0.88616917
125MP0001819_abnormal_immune_cell0.87048004
126MP0008872_abnormal_physiological_respon0.87026531
127MP0002090_abnormal_vision0.86255358
128MP0004381_abnormal_hair_follicle0.85293177
129MP0003763_abnormal_thymus_physiology0.84878412
130MP0005423_abnormal_somatic_nervous0.83015451
131MP0003631_nervous_system_phenotype0.82211734
132MP0002132_abnormal_respiratory_system0.82184552
133MP0001764_abnormal_homeostasis0.82065179
134MP0009115_abnormal_fat_cell0.81584714
135MP0004947_skin_inflammation0.78597039
136MP0000920_abnormal_myelination0.78425298
137MP0002066_abnormal_motor_capabilities/c0.76695502
138MP0003879_abnormal_hair_cell0.76365192
139MP0002069_abnormal_eating/drinking_beha0.76209420
140MP0003075_altered_response_to0.75993031
141MP0008438_abnormal_cutaneous_collagen0.75462441
142MP0004215_abnormal_myocardial_fiber0.74471894
143MP0005551_abnormal_eye_electrophysiolog0.74367329
144MP0000858_altered_metastatic_potential0.72966810
145MP0004885_abnormal_endolymph0.72921095
146MP0001661_extended_life_span0.72778965
147MP0009764_decreased_sensitivity_to0.71528544
148MP0005376_homeostasis/metabolism_phenot0.71505305
149MP0005310_abnormal_salivary_gland0.71324379
150MP0003566_abnormal_cell_adhesion0.71167873
151MP0001970_abnormal_pain_threshold0.70787573
152MP0006276_abnormal_autonomic_nervous0.69379963
153MP0002405_respiratory_system_inflammati0.68459901
154MP0003959_abnormal_lean_body0.68207326
155MP0003953_abnormal_hormone_level0.66956571
156MP0002229_neurodegeneration0.66415988
157MP0004811_abnormal_neuron_physiology0.64747263
158MP0006138_congestive_heart_failure0.63705348
159MP0003045_fibrosis0.61690065
160MP0000230_abnormal_systemic_arterial0.61316938
161MP0002254_reproductive_system_inflammat0.60949272
162MP0009643_abnormal_urine_homeostasis0.60472722
163MP0003632_abnormal_nervous_system0.60428067
164MP0004085_abnormal_heartbeat0.60253595
165MP0005620_abnormal_muscle_contractility0.59648761
166MP0005167_abnormal_blood-brain_barrier0.59544278
167MP0005452_abnormal_adipose_tissue0.59102926

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.64058491
2Xanthomatosis (HP:0000991)4.37861060
3Intrahepatic cholestasis (HP:0001406)4.06544640
4Eczematoid dermatitis (HP:0000976)4.03497109
5Complement deficiency (HP:0004431)3.95118686
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.90193608
7Hyperlipoproteinemia (HP:0010980)3.83599468
8Hypobetalipoproteinemia (HP:0003563)3.77849621
9Epidermoid cyst (HP:0200040)3.69627178
10Focal motor seizures (HP:0011153)3.53774018
11Recurrent gram-negative bacterial infections (HP:0005420)3.44556513
12Gingival bleeding (HP:0000225)3.40491536
13Myokymia (HP:0002411)3.39112845
14Ketosis (HP:0001946)3.30597716
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.25158702
16Orchitis (HP:0100796)3.24968133
17Peritonitis (HP:0002586)3.19863898
18Hypolipoproteinemia (HP:0010981)3.18194531
19Recurrent bacterial skin infections (HP:0005406)3.13535119
20Recurrent abscess formation (HP:0002722)3.10209048
21Malnutrition (HP:0004395)3.07815604
22Prolonged partial thromboplastin time (HP:0003645)3.07180224
23Gastrointestinal infarctions (HP:0005244)3.07013273
24Hypoalphalipoproteinemia (HP:0003233)3.05590290
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.04987020
26Hyperglycinuria (HP:0003108)2.99988500
27Abnormality of glutamine family amino acid metabolism (HP:0010902)2.99929322
28Gingivitis (HP:0000230)2.98383246
29Ketoacidosis (HP:0001993)2.95706578
30Abnormality of glycine metabolism (HP:0010895)2.95691982
31Abnormality of serine family amino acid metabolism (HP:0010894)2.95691982
32Optic neuritis (HP:0100653)2.95148862
33Retrobulbar optic neuritis (HP:0100654)2.95148862
34Hyperammonemia (HP:0001987)2.92269453
35Subacute progressive viral hepatitis (HP:0006572)2.92233405
36Abnormality of the common coagulation pathway (HP:0010990)2.89457864
37Skin nodule (HP:0200036)2.88141161
38Myositis (HP:0100614)2.86037019
39Abnormality of macrophages (HP:0004311)2.81474315
40Focal seizures (HP:0007359)2.81118111
41Action tremor (HP:0002345)2.77631933
42Hyperglycinemia (HP:0002154)2.72144449
43Hypoglycemic coma (HP:0001325)2.70387771
44Oligomenorrhea (HP:0000876)2.68992292
45Steatorrhea (HP:0002570)2.67895823
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.65657899
47Abnormality of complement system (HP:0005339)2.61274119
48Papillary thyroid carcinoma (HP:0002895)2.59808998
49Cerebral inclusion bodies (HP:0100314)2.55949312
50Hypercholesterolemia (HP:0003124)2.51389838
51Neurofibrillary tangles (HP:0002185)2.50925046
52Visual hallucinations (HP:0002367)2.47238495
53Impaired social interactions (HP:0000735)2.46565451
54Abnormal social behavior (HP:0012433)2.46565451
55Intention tremor (HP:0002080)2.46450174
56Systemic lupus erythematosus (HP:0002725)2.38440728
57Dysdiadochokinesis (HP:0002075)2.37269172
58Urinary glycosaminoglycan excretion (HP:0003541)2.37150107
59Mucopolysacchariduria (HP:0008155)2.37150107
60Cholecystitis (HP:0001082)2.36643669
61Abnormal gallbladder physiology (HP:0012438)2.36643669
62Hyperventilation (HP:0002883)2.34807214
63Dysmetric saccades (HP:0000641)2.34755611
64Glomerulonephritis (HP:0000099)2.31952299
65Status epilepticus (HP:0002133)2.31480718
66Chronic diarrhea (HP:0002028)2.27456051
67Fat malabsorption (HP:0002630)2.26752790
68Periodontitis (HP:0000704)2.25831673
69Scanning speech (HP:0002168)2.25717397
70Pulmonary embolism (HP:0002204)2.25649415
71Generalized tonic-clonic seizures (HP:0002069)2.25522390
72Abnormality of the lower motor neuron (HP:0002366)2.25384500
73Pheochromocytoma (HP:0002666)2.24555149
74Torticollis (HP:0000473)2.23604439
75Impaired vibration sensation in the lower limbs (HP:0002166)2.22779297
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22364278
77Conjugated hyperbilirubinemia (HP:0002908)2.22340480
78Arterial thrombosis (HP:0004420)2.21819485
79Blue irides (HP:0000635)2.21584505
80Absence seizures (HP:0002121)2.21399697
81Ocular albinism (HP:0001107)2.21369682
82Dysmetria (HP:0001310)2.18945320
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.18239547
84Postural instability (HP:0002172)2.17570558
85Atonic seizures (HP:0010819)2.17450893
86Insidious onset (HP:0003587)2.16049822
87Termporal pattern (HP:0011008)2.16049822
88Acanthocytosis (HP:0001927)2.15567466
89Poor eye contact (HP:0000817)2.15299455
90Increased CSF protein (HP:0002922)2.14382398
91Pigmentary retinal degeneration (HP:0001146)2.14151445
92Resting tremor (HP:0002322)2.13494244
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13326306
94Abnormality of polysaccharide metabolism (HP:0011012)2.13326306
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13326306
96Vascular calcification (HP:0004934)2.13173128
97Progressive cerebellar ataxia (HP:0002073)2.13018458
98Abnormality of sulfur amino acid metabolism (HP:0004339)2.12362696
99Keratoconjunctivitis sicca (HP:0001097)2.11561576
100Abnormality of the intrinsic pathway (HP:0010989)2.08289588
101Abnormal eating behavior (HP:0100738)2.07570762
102Asymmetry of the thorax (HP:0001555)2.06538832
103Joint hemorrhage (HP:0005261)2.05922542
104Spontaneous hematomas (HP:0007420)2.05886316
105Recurrent skin infections (HP:0001581)2.05411396
106Vasculitis (HP:0002633)2.05267664
107Abnormal gallbladder morphology (HP:0012437)2.04759330
108Gout (HP:0001997)2.03951460
109Amyloidosis (HP:0011034)2.03682447
110Focal dystonia (HP:0004373)2.03382592
111Abnormality of fatty-acid metabolism (HP:0004359)2.03261839
112Supranuclear gaze palsy (HP:0000605)2.02701385
113Generalized hypopigmentation of hair (HP:0011358)2.02650233
114Cholelithiasis (HP:0001081)2.02494308
115Sensorimotor neuropathy (HP:0007141)2.02153686
116Epileptic encephalopathy (HP:0200134)2.01575382
117Polycythemia (HP:0001901)2.01347170
118Abnormality of purine metabolism (HP:0004352)2.00970803
119Craniofacial dystonia (HP:0012179)2.00198929
120Hypoglycemic seizures (HP:0002173)2.00093525
121Abnormality of the corticospinal tract (HP:0002492)1.99947788
122Turricephaly (HP:0000262)1.99753412
123Cardiovascular calcification (HP:0011915)1.98921543
124Urinary bladder sphincter dysfunction (HP:0002839)1.93866899
125Chest pain (HP:0100749)1.91937348
126Keratoconjunctivitis (HP:0001096)1.91771733
127Hydroxyprolinuria (HP:0003080)1.91530287
128Abnormality of proline metabolism (HP:0010907)1.91530287
129Arterial tortuosity (HP:0005116)1.91095759
130Spontaneous abortion (HP:0005268)1.90719243
131Cerebral hemorrhage (HP:0001342)1.90347412
132Myocardial infarction (HP:0001658)1.89291041
133Nephritis (HP:0000123)1.89183063
134Osteomyelitis (HP:0002754)1.89079091
135Dysostosis multiplex (HP:0000943)1.88420361
136Coarse hair (HP:0002208)1.87180199
137Abnormality of the peritoneum (HP:0002585)1.86258494
138Abnormality of T cell number (HP:0011839)1.85373440
139Tetraplegia (HP:0002445)1.85307299
140Spastic gait (HP:0002064)1.85266936
141Dialeptic seizures (HP:0011146)1.84724922
142Osteolytic defects of the hand bones (HP:0009699)1.84234661
143Osteolytic defects of the phalanges of the hand (HP:0009771)1.84234661
144Anxiety (HP:0000739)1.84200922
145Depression (HP:0000716)1.83741500
146Joint swelling (HP:0001386)1.83558299
147T lymphocytopenia (HP:0005403)1.83039031
148Urinary urgency (HP:0000012)1.81788971
149Abnormality of vitamin metabolism (HP:0100508)1.81182571
150Metabolic acidosis (HP:0001942)1.81050289
151Acanthosis nigricans (HP:0000956)1.80803110
152Impaired vibratory sensation (HP:0002495)1.80720153
153Hypertriglyceridemia (HP:0002155)1.80572542
154Thyroid carcinoma (HP:0002890)1.80435789
155Abnormal platelet volume (HP:0011876)1.79985604
156Mitral stenosis (HP:0001718)1.79905696
157Neuroendocrine neoplasm (HP:0100634)1.78947114
158Acute hepatic failure (HP:0006554)1.78151325
159Papilledema (HP:0001085)1.77936927
160Thickened calvaria (HP:0002684)1.77773440
161Prolonged bleeding time (HP:0003010)1.77714693
162Recurrent fungal infections (HP:0002841)1.76913929
163Epistaxis (HP:0000421)1.76114133
164Iris hypopigmentation (HP:0007730)1.75524310
165Viral hepatitis (HP:0006562)1.74261256
166Urticaria (HP:0001025)1.73334571
167Pulmonary infiltrates (HP:0002113)1.73100540
168Testicular neoplasm (HP:0010788)1.72576212
169Fair hair (HP:0002286)1.72492306
170Episodic fever (HP:0001954)1.71536943
171Meningitis (HP:0001287)1.71135773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA42.81185563
2BMPR22.71248954
3MAP3K92.63970744
4NTRK32.57999439
5MAP3K42.57647973
6MAP2K42.45572974
7FGFR32.36057369
8TYK22.34595879
9PRPF4B2.27526959
10DAPK22.24000509
11MAP2K32.19969808
12MAP3K142.11161674
13FRK2.07116316
14CAMK1G2.02867343
15STK242.01777110
16PAK61.96638331
17TRIB31.96245494
18BLK1.89206681
19YES11.88359251
20SIK11.85982433
21CAMK1D1.85652910
22FGFR21.81493993
23RIPK11.76144496
24MAP3K31.74111930
25KSR21.73466652
26IRAK41.72384036
27PRKD31.69553473
28MINK11.67110004
29ACVR1B1.66790967
30INSRR1.62754381
31CSK1.62490420
32NTRK11.60191341
33CAMKK11.59508270
34TRPM71.54004615
35BCKDK1.50816901
36MAP2K71.46685689
37MARK11.45427071
38MAP3K21.44035229
39LMTK21.42780181
40PDK41.32611961
41PDK31.32611961
42RET1.30362251
43JAK31.29901267
44ZAP701.21465884
45STK381.21432679
46ERBB31.18430217
47PDPK11.17681465
48AKT31.17363266
49OXSR11.17059827
50PRKCH1.16440290
51RIPK41.14188310
52PAK31.14108104
53CDK51.12399310
54PIK3CG1.11832416
55NEK91.09244431
56IRAK11.08246302
57CAMKK21.07148565
58SGK4941.06367767
59SGK2231.06367767
60KSR11.05928690
61PDK11.02628116
62SGK31.00921660
63EPHB11.00755927
64FGR0.99872929
65NTRK20.97229809
66WNK10.96256168
67STK390.94952986
68MST1R0.94595090
69GRK60.94157833
70EPHA30.93369040
71MAP3K70.92955718
72TEC0.89100101
73STK110.87889352
74EEF2K0.87604608
75SYK0.86750097
76PTK2B0.86384134
77FER0.86206370
78PINK10.86103191
79TYRO30.85342796
80ERN10.83970211
81TGFBR20.83368553
82FGFR40.82312848
83GRK50.82281297
84HCK0.81281033
85LATS20.80662854
86SGK20.80002629
87PRKCG0.79961321
88PKN20.79760675
89STK30.79483312
90FES0.79243940
91ERBB40.79137622
92PDGFRA0.75773549
93PHKG10.75600330
94PHKG20.75600330
95CAMK2A0.75206874
96SIK30.75060110
97TBK10.74051475
98BTK0.73833360
99CDK60.73708929
100STK38L0.73308338
101MAP2K10.73089231
102PRKAA20.72455230
103PRKG20.71637639
104IKBKE0.71635980
105BRD40.71321700
106MAP3K130.70956206
107PIK3CA0.69649685
108CAMK2B0.69534823
109CAMK2G0.69308220
110WNK40.69200775
111PTK60.68998788
112CDK190.67968652
113PRKCZ0.67836252
114IRAK20.67750014
115CAMK10.66798076
116PDGFRB0.66683906
117ICK0.66104367
118DDR20.66037218
119MAP3K120.65465570
120LATS10.64864383
121PDK20.62304251
122MET0.62070685
123PNCK0.61998429
124CAMK2D0.60430721
125SGK10.59809115
126MAPK110.59755581
127MELK0.59671584
128PRKAA10.58442192
129TAOK10.58275843
130CSNK1G20.58188738
131NEK60.57768496
132MAP3K10.57237312
133PTK20.57212787
134SIK20.56668529
135MAP3K50.55645597
136NLK0.55593667
137PRKACG0.55370087
138DAPK10.55085118
139MAP3K60.54622700
140PLK20.54342123
141JAK10.54018751
142JAK20.53552185
143RPS6KA30.52000969
144MARK20.51228258
145BMX0.51064126
146CSF1R0.50870795
147PRKD10.50287443
148LCK0.50268852
149SCYL20.49104998
150LYN0.48305216
151MAP2K60.46759738
152MATK0.45974272
153MAP4K10.45331843
154MARK30.44672865
155TAOK30.43457600
156FYN0.42994263

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.75229680
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.79556865
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61287727
4Arginine biosynthesis_Homo sapiens_hsa002202.46984097
5PPAR signaling pathway_Homo sapiens_hsa033202.03638210
6Butanoate metabolism_Homo sapiens_hsa006501.97397401
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.92673590
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.92392685
9Propanoate metabolism_Homo sapiens_hsa006401.90121298
10Fatty acid degradation_Homo sapiens_hsa000711.89819427
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85085128
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83455471
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.82584639
14Fatty acid metabolism_Homo sapiens_hsa012121.73258631
15Tryptophan metabolism_Homo sapiens_hsa003801.72540051
16Leishmaniasis_Homo sapiens_hsa051401.66681068
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56921144
18Bile secretion_Homo sapiens_hsa049761.56735754
19Complement and coagulation cascades_Homo sapiens_hsa046101.53607294
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50603404
21Osteoclast differentiation_Homo sapiens_hsa043801.49318776
22Fatty acid biosynthesis_Homo sapiens_hsa000611.44112663
23B cell receptor signaling pathway_Homo sapiens_hsa046621.41764916
24Fat digestion and absorption_Homo sapiens_hsa049751.39588425
25Pyruvate metabolism_Homo sapiens_hsa006201.33649979
26Caffeine metabolism_Homo sapiens_hsa002321.30591661
27Peroxisome_Homo sapiens_hsa041461.30428791
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28470991
29Nicotine addiction_Homo sapiens_hsa050331.23721489
30beta-Alanine metabolism_Homo sapiens_hsa004101.22880487
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22325537
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21722357
33Synaptic vesicle cycle_Homo sapiens_hsa047211.20384660
34Glycerolipid metabolism_Homo sapiens_hsa005611.19673449
35GABAergic synapse_Homo sapiens_hsa047271.19620073
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18161242
37Tuberculosis_Homo sapiens_hsa051521.18006245
38Dorso-ventral axis formation_Homo sapiens_hsa043201.16776208
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14415721
40Non-small cell lung cancer_Homo sapiens_hsa052231.14272259
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12717725
42Inositol phosphate metabolism_Homo sapiens_hsa005621.11539665
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09965876
44Phenylalanine metabolism_Homo sapiens_hsa003601.06775256
45Starch and sucrose metabolism_Homo sapiens_hsa005001.06190924
46Renin-angiotensin system_Homo sapiens_hsa046141.03559028
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02332366
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02031053
49Circadian entrainment_Homo sapiens_hsa047131.00681283
50Sulfur metabolism_Homo sapiens_hsa009200.99402198
51Toxoplasmosis_Homo sapiens_hsa051450.98844964
52Other glycan degradation_Homo sapiens_hsa005110.98630739
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98589376
54Glutamatergic synapse_Homo sapiens_hsa047240.96699188
55Histidine metabolism_Homo sapiens_hsa003400.95231663
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95218738
57Renal cell carcinoma_Homo sapiens_hsa052110.94656453
58Carbon metabolism_Homo sapiens_hsa012000.94004430
59Salivary secretion_Homo sapiens_hsa049700.93737542
60Prolactin signaling pathway_Homo sapiens_hsa049170.93414895
61Type II diabetes mellitus_Homo sapiens_hsa049300.91682438
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91135312
63Morphine addiction_Homo sapiens_hsa050320.91094829
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90970867
65Long-term potentiation_Homo sapiens_hsa047200.90955434
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89569524
67Renin secretion_Homo sapiens_hsa049240.87869803
68Hepatitis C_Homo sapiens_hsa051600.87706812
69ABC transporters_Homo sapiens_hsa020100.87250604
70Pancreatic cancer_Homo sapiens_hsa052120.86737013
71Chemical carcinogenesis_Homo sapiens_hsa052040.86641782
72Amphetamine addiction_Homo sapiens_hsa050310.86608011
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.85801281
74Tyrosine metabolism_Homo sapiens_hsa003500.85015084
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.84745119
76Olfactory transduction_Homo sapiens_hsa047400.84663826
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83478383
78Insulin secretion_Homo sapiens_hsa049110.83317862
79Influenza A_Homo sapiens_hsa051640.83260170
80Platelet activation_Homo sapiens_hsa046110.82230878
81Fatty acid elongation_Homo sapiens_hsa000620.81830537
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80645804
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.80637203
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80380352
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80037359
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78414321
87Chemokine signaling pathway_Homo sapiens_hsa040620.77353223
88Chronic myeloid leukemia_Homo sapiens_hsa052200.76873304
89Dopaminergic synapse_Homo sapiens_hsa047280.76743823
90Measles_Homo sapiens_hsa051620.74802833
91Gastric acid secretion_Homo sapiens_hsa049710.74626986
92Staphylococcus aureus infection_Homo sapiens_hsa051500.74533863
93FoxO signaling pathway_Homo sapiens_hsa040680.74507468
94TNF signaling pathway_Homo sapiens_hsa046680.73890920
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73500995
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72808098
97Retinol metabolism_Homo sapiens_hsa008300.71629001
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.71418090
99Legionellosis_Homo sapiens_hsa051340.70360336
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.70140783
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.69897487
102Sphingolipid metabolism_Homo sapiens_hsa006000.68382453
103Endometrial cancer_Homo sapiens_hsa052130.67468093
104Biosynthesis of amino acids_Homo sapiens_hsa012300.67227184
105Pertussis_Homo sapiens_hsa051330.66582608
106Pancreatic secretion_Homo sapiens_hsa049720.66576420
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66276922
108Phagosome_Homo sapiens_hsa041450.66237887
109Glucagon signaling pathway_Homo sapiens_hsa049220.66082853
110mTOR signaling pathway_Homo sapiens_hsa041500.65300624
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65278951
112African trypanosomiasis_Homo sapiens_hsa051430.64383552
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.64148287
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63801433
115Glioma_Homo sapiens_hsa052140.62545400
116Cholinergic synapse_Homo sapiens_hsa047250.62498870
117T cell receptor signaling pathway_Homo sapiens_hsa046600.62248364
118Cocaine addiction_Homo sapiens_hsa050300.60216422
119Acute myeloid leukemia_Homo sapiens_hsa052210.59402101
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58912578
121Type I diabetes mellitus_Homo sapiens_hsa049400.58669350
122Mineral absorption_Homo sapiens_hsa049780.58381770
123Thyroid hormone synthesis_Homo sapiens_hsa049180.58297776
124Hepatitis B_Homo sapiens_hsa051610.57741627
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57510404
126Long-term depression_Homo sapiens_hsa047300.57200742
127Choline metabolism in cancer_Homo sapiens_hsa052310.56703132
128Vitamin B6 metabolism_Homo sapiens_hsa007500.56483044
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55497575
130AMPK signaling pathway_Homo sapiens_hsa041520.55426828
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54989838
132Amoebiasis_Homo sapiens_hsa051460.54756685
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54258588
134Insulin resistance_Homo sapiens_hsa049310.53992349
135Taste transduction_Homo sapiens_hsa047420.52639490
136Graft-versus-host disease_Homo sapiens_hsa053320.51660498
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.51087231
138NF-kappa B signaling pathway_Homo sapiens_hsa040640.51064678
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.50410881
140cAMP signaling pathway_Homo sapiens_hsa040240.49614990
141VEGF signaling pathway_Homo sapiens_hsa043700.49581766
142Autoimmune thyroid disease_Homo sapiens_hsa053200.49440809
143Oxytocin signaling pathway_Homo sapiens_hsa049210.49368058
144Allograft rejection_Homo sapiens_hsa053300.49096269
145Malaria_Homo sapiens_hsa051440.48688058
146Galactose metabolism_Homo sapiens_hsa000520.48665174
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.48559624
148Vitamin digestion and absorption_Homo sapiens_hsa049770.47988570
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.47912430
150Lysine degradation_Homo sapiens_hsa003100.46711484
151Calcium signaling pathway_Homo sapiens_hsa040200.43863243
152Insulin signaling pathway_Homo sapiens_hsa049100.43332766
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.42718054
154GnRH signaling pathway_Homo sapiens_hsa049120.42601731
155cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40351952
156Prion diseases_Homo sapiens_hsa050200.39825276
157* Glycerophospholipid metabolism_Homo sapiens_hsa005640.39046232
158Estrogen signaling pathway_Homo sapiens_hsa049150.38361236
159Gap junction_Homo sapiens_hsa045400.37775677
160Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37237541
161Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36421046
162Selenocompound metabolism_Homo sapiens_hsa004500.36068780

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