LPIN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)5.73413828
2bundle of His cell to Purkinje myocyte communication (GO:0086069)5.66021744
3intestinal absorption (GO:0050892)5.56535038
4desmosome organization (GO:0002934)4.98951190
5water-soluble vitamin biosynthetic process (GO:0042364)4.63295026
6molting cycle (GO:0042303)4.42457113
7hair cycle (GO:0042633)4.42457113
8sulfation (GO:0051923)4.23672026
9indole-containing compound catabolic process (GO:0042436)4.00035844
10indolalkylamine catabolic process (GO:0046218)4.00035844
11tryptophan catabolic process (GO:0006569)4.00035844
12hemidesmosome assembly (GO:0031581)3.99434181
13purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.94040909
143-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.94040909
15regulation of bile acid biosynthetic process (GO:0070857)3.88448024
16epithelial cell-cell adhesion (GO:0090136)3.82129645
17behavioral response to nicotine (GO:0035095)3.73732050
18adhesion of symbiont to host (GO:0044406)3.69740187
19indolalkylamine metabolic process (GO:0006586)3.61299958
20DNA deamination (GO:0045006)3.57280379
21adhesion of symbiont to host cell (GO:0044650)3.56076465
22virion attachment to host cell (GO:0019062)3.56076465
23positive regulation of fatty acid oxidation (GO:0046321)3.55280892
24kynurenine metabolic process (GO:0070189)3.54805938
25aromatic amino acid family catabolic process (GO:0009074)3.53736392
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.50343304
27transepithelial transport (GO:0070633)3.42507222
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.42227042
29protein retention in ER lumen (GO:0006621)3.35055353
30regulation of glomerulus development (GO:0090192)3.34998590
31hormone catabolic process (GO:0042447)3.30925158
32cellular ketone body metabolic process (GO:0046950)3.29785788
33tryptophan metabolic process (GO:0006568)3.26829881
34homocysteine metabolic process (GO:0050667)3.26310242
35exogenous drug catabolic process (GO:0042738)3.22576550
36regulation of triglyceride catabolic process (GO:0010896)3.22542908
37cellular response to ATP (GO:0071318)3.21590057
38phospholipid efflux (GO:0033700)3.20085607
39sulfur amino acid catabolic process (GO:0000098)3.19590105
40peptide catabolic process (GO:0043171)3.14985721
41cysteine metabolic process (GO:0006534)3.14130285
42negative regulation of sterol transport (GO:0032372)3.10925978
43negative regulation of cholesterol transport (GO:0032375)3.10925978
44ketone body metabolic process (GO:1902224)3.08650528
45lipoprotein metabolic process (GO:0042157)3.08551609
46positive regulation of lipoprotein lipase activity (GO:0051006)3.07343846
47positive regulation of triglyceride lipase activity (GO:0061365)3.07343846
48cholesterol homeostasis (GO:0042632)3.06949059
49bile acid and bile salt transport (GO:0015721)3.06638456
50regulation of hippo signaling (GO:0035330)3.05952883
51sterol homeostasis (GO:0055092)3.04091973
52positive regulation of fatty acid beta-oxidation (GO:0032000)3.03813369
53aromatic amino acid family metabolic process (GO:0009072)3.03417016
54vitamin A metabolic process (GO:0006776)3.03408673
55L-phenylalanine catabolic process (GO:0006559)3.01649508
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.01649508
57somite development (GO:0061053)3.00128407
58vitamin biosynthetic process (GO:0009110)2.99889804
59regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.99264327
60sulfate transmembrane transport (GO:1902358)2.96548405
61plasma lipoprotein particle remodeling (GO:0034369)2.93779203
62protein-lipid complex remodeling (GO:0034368)2.93779203
63macromolecular complex remodeling (GO:0034367)2.93779203
64positive regulation of glomerulus development (GO:0090193)2.93508606
65skin morphogenesis (GO:0043589)2.92489513
66angiotensin maturation (GO:0002003)2.92165944
67transcytosis (GO:0045056)2.92094427
68positive regulation of fatty acid transport (GO:2000193)2.92025322
69reverse cholesterol transport (GO:0043691)2.90865682
70low-density lipoprotein particle clearance (GO:0034383)2.90600131
71renal absorption (GO:0070293)2.90121390
72gap junction assembly (GO:0016264)2.88892977
73regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.87927757
74acylglycerol homeostasis (GO:0055090)2.85987482
75triglyceride homeostasis (GO:0070328)2.85987482
76high-density lipoprotein particle remodeling (GO:0034375)2.85621690
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.83770703
78L-phenylalanine metabolic process (GO:0006558)2.83770703
79regulation of mesoderm development (GO:2000380)2.83598574
80Golgi transport vesicle coating (GO:0048200)2.81290851
81COPI coating of Golgi vesicle (GO:0048205)2.81290851
82mannosylation (GO:0097502)2.80750688
83negative regulation of fatty acid biosynthetic process (GO:0045717)2.80326856
84regulation of cholesterol homeostasis (GO:2000188)2.79298030
85drug catabolic process (GO:0042737)2.77383713
86COPII vesicle coating (GO:0048208)2.77332658
87positive regulation of triglyceride metabolic process (GO:0090208)2.75873489
88positive regulation of triglyceride biosynthetic process (GO:0010867)2.74470057
89oxidative demethylation (GO:0070989)2.74108728
90L-fucose metabolic process (GO:0042354)2.73527493
91L-fucose catabolic process (GO:0042355)2.73527493
92fucose catabolic process (GO:0019317)2.73527493
93amine catabolic process (GO:0009310)2.72135252
94cellular biogenic amine catabolic process (GO:0042402)2.72135252
95flavonoid metabolic process (GO:0009812)2.70822295
96detection of light stimulus involved in sensory perception (GO:0050962)2.69656799
97detection of light stimulus involved in visual perception (GO:0050908)2.69656799
98striated muscle atrophy (GO:0014891)2.69618908
99indole-containing compound metabolic process (GO:0042430)2.69335959
100epoxygenase P450 pathway (GO:0019373)2.66993788
101receptor guanylyl cyclase signaling pathway (GO:0007168)2.66854848
102cornea development in camera-type eye (GO:0061303)2.65567075
103nephron tubule morphogenesis (GO:0072078)2.65513399
104nephron epithelium morphogenesis (GO:0072088)2.65513399
105intestinal epithelial cell development (GO:0060576)2.65053972
106protein complex biogenesis (GO:0070271)2.65011473
107cellular anion homeostasis (GO:0030002)2.64754859
108actin filament depolymerization (GO:0030042)2.64083379
109benzene-containing compound metabolic process (GO:0042537)2.63023516
110positive regulation of icosanoid secretion (GO:0032305)2.61968392
111positive regulation of p38MAPK cascade (GO:1900745)2.60724164
112glucuronate metabolic process (GO:0019585)2.60322407
113uronic acid metabolic process (GO:0006063)2.60322407
114arginine metabolic process (GO:0006525)2.60004472
115drug metabolic process (GO:0017144)2.59690680
116intermediate filament organization (GO:0045109)2.59440892
117UDP-N-acetylglucosamine metabolic process (GO:0006047)2.59049785
118plasma lipoprotein particle assembly (GO:0034377)2.58461065
119keratinization (GO:0031424)2.58282167
120protein-lipid complex assembly (GO:0065005)2.56607803
121regulation of cardioblast differentiation (GO:0051890)2.55299482
122cellular glucuronidation (GO:0052695)2.55048435
123regulation of cholesterol esterification (GO:0010872)2.54868137
124lysine catabolic process (GO:0006554)2.54243705
125lysine metabolic process (GO:0006553)2.54243705
126regulation of triglyceride biosynthetic process (GO:0010866)2.54096019
127IMP biosynthetic process (GO:0006188)2.53761084
128positive regulation of fatty acid biosynthetic process (GO:0045723)2.53687474
129regulation of cell proliferation involved in kidney development (GO:1901722)2.52769585
130chondrocyte proliferation (GO:0035988)2.52098862
1314-hydroxyproline metabolic process (GO:0019471)2.51987879
132GPI anchor metabolic process (GO:0006505)2.51598054
133positive regulation of glycoprotein metabolic process (GO:1903020)2.51109532
134tooth mineralization (GO:0034505)2.50381658
135regulation of tight junction assembly (GO:2000810)2.49276799
136very-low-density lipoprotein particle assembly (GO:0034379)2.49062723
137urea cycle (GO:0000050)2.49030821
138urea metabolic process (GO:0019627)2.49030821
139regulation of triglyceride metabolic process (GO:0090207)2.48914178
140negative regulation of lipase activity (GO:0060192)2.48508381
141sulfate transport (GO:0008272)2.48505083
142regulation of water loss via skin (GO:0033561)2.48388034
143glycine metabolic process (GO:0006544)2.45776284
144mitochondrial respiratory chain complex I assembly (GO:0032981)2.45752758
145NADH dehydrogenase complex assembly (GO:0010257)2.45752758
146mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.45752758
147phosphate ion homeostasis (GO:0055062)2.45618561
148trivalent inorganic anion homeostasis (GO:0072506)2.45618561
149S-adenosylmethionine metabolic process (GO:0046500)2.45513530
150regulation of cholesterol metabolic process (GO:0090181)2.44984159
151regulation of fibrinolysis (GO:0051917)2.44420813
152primary amino compound metabolic process (GO:1901160)2.43560287
153xenobiotic catabolic process (GO:0042178)2.42784132
154negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.42623632
155preassembly of GPI anchor in ER membrane (GO:0016254)2.42261531
156negative regulation of keratinocyte proliferation (GO:0010839)2.42191079
157serine family amino acid catabolic process (GO:0009071)2.41951395
158regulation of sequestering of triglyceride (GO:0010889)2.41814230
159lipid homeostasis (GO:0055088)2.41569916
160ventricular cardiac muscle cell action potential (GO:0086005)2.40881254
161positive regulation of Cdc42 GTPase activity (GO:0043089)2.39528974
162peptidyl-glutamic acid carboxylation (GO:0017187)2.39130327
163protein carboxylation (GO:0018214)2.39130327
164amino-acid betaine metabolic process (GO:0006577)2.38608742
165drug transmembrane transport (GO:0006855)2.38564508
166cholesterol efflux (GO:0033344)2.37654613
167biotin metabolic process (GO:0006768)2.36807812
168regulation of cholesterol transport (GO:0032374)2.36452117
169regulation of sterol transport (GO:0032371)2.36452117
170skeletal muscle adaptation (GO:0043501)2.36246548
171positive regulation of glycoprotein biosynthetic process (GO:0010560)2.35442263
172cholesterol transport (GO:0030301)2.35122214
173sterol transport (GO:0015918)2.35122214
174multicellular organismal water homeostasis (GO:0050891)2.35028381
175serine family amino acid metabolic process (GO:0009069)2.34769940
176anterior/posterior axis specification, embryo (GO:0008595)2.34618975
177plasma lipoprotein particle clearance (GO:0034381)2.34613081
178negative regulation of fibrinolysis (GO:0051918)2.34462248
179skin development (GO:0043588)2.34306813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.63372708
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.62706036
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.75703184
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.39423774
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.18171162
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.13508795
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.07905862
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.89028633
9VDR_22108803_ChIP-Seq_LS180_Human2.76684274
10ZNF274_21170338_ChIP-Seq_K562_Hela2.71329795
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.68650523
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.59762820
13CLOCK_20551151_ChIP-Seq_293T_Human2.51981800
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.26139647
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.21755409
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21154709
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10500244
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.05236497
19GBX2_23144817_ChIP-Seq_PC3_Human2.02251724
20STAT3_1855785_ChIP-Seq_MESCs_Mouse2.02193483
21SOX2_27498859_Chip-Seq_STOMACH_Mouse2.00814183
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.94678537
23GATA4_25053715_ChIP-Seq_YYC3_Human1.94556663
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.91385883
25ATF3_27146783_Chip-Seq_COLON_Human1.90153021
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.89724355
27RACK7_27058665_Chip-Seq_MCF-7_Human1.74599012
28GATA6_25053715_ChIP-Seq_YYC3_Human1.74375963
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72948597
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72701908
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72164906
32AR_21909140_ChIP-Seq_LNCAP_Human1.67805041
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66882893
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66153732
35SOX2_20726797_ChIP-Seq_SW620_Human1.65522096
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64159537
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63972752
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62833521
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.61534023
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.61515026
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60557881
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59449000
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59037522
44ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.58923207
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.58106907
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57855525
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55437428
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54927070
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54784371
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.54666775
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.54046835
52ER_23166858_ChIP-Seq_MCF-7_Human1.53865383
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.52119578
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51424321
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50649184
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50569272
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48883872
58SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48883872
59* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47490822
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47006479
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46033342
62TDRD3_21172665_ChIP-Seq_MCF-7_Human1.45888362
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44073397
64BCAT_22108803_ChIP-Seq_LS180_Human1.43995711
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43806756
66P63_26484246_Chip-Seq_KERATINOCYTES_Human1.43184631
67ZNF263_19887448_ChIP-Seq_K562_Human1.41671123
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41159165
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.41159165
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.39145344
71NCOR_22424771_ChIP-Seq_293T_Human1.36501990
72IGF1R_20145208_ChIP-Seq_DFB_Human1.35329966
73AR_20517297_ChIP-Seq_VCAP_Human1.34161380
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33961630
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32813426
76AHR_22903824_ChIP-Seq_MCF-7_Human1.32365597
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32175330
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.30024834
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26513306
80* RUNX1_27514584_Chip-Seq_MCF-7_Human1.26006557
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25856739
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25395101
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24550952
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24399780
85HOXB7_26014856_ChIP-Seq_BT474_Human1.23241361
86ERA_21632823_ChIP-Seq_H3396_Human1.22715435
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.22535451
88CDX2_22108803_ChIP-Seq_LS180_Human1.22273702
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22079725
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20775327
91NANOG_20526341_ChIP-Seq_ESCs_Human1.20774816
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20219063
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19503040
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19503040
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19503040
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19502094
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18052165
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17116454
99IRF1_19129219_ChIP-ChIP_H3396_Human1.16191384
100MYC_19829295_ChIP-Seq_ESCs_Human1.14232178
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14221234
102TCF4_22108803_ChIP-Seq_LS180_Human1.12738737
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12620111
104EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12485058
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12408366
106* FOXH1_21741376_ChIP-Seq_ESCs_Human1.12372361
107EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12363435
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.12096667
109ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11324100
110P53_21459846_ChIP-Seq_SAOS-2_Human1.10915757
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10846977
112TAF2_19829295_ChIP-Seq_ESCs_Human1.10834620
113FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10651742
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.10397156
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10334917
116SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10266432
117EZH2_27294783_Chip-Seq_ESCs_Mouse1.08991549
118NANOG_19829295_ChIP-Seq_ESCs_Human1.08272537
119SOX2_19829295_ChIP-Seq_ESCs_Human1.08272537
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08036150
121HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07609721
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.07319631
123SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07185487
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06613025
125EZH2_22144423_ChIP-Seq_EOC_Human1.05808945
126P300_19829295_ChIP-Seq_ESCs_Human1.05663825
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05383252
128PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05270841
129HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05109232
130* GATA3_24758297_ChIP-Seq_MCF-7_Human1.04912070
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04620167
132CBP_20019798_ChIP-Seq_JUKART_Human1.04620167
133PIAS1_25552417_ChIP-Seq_VCAP_Human1.04139557
134RAC3_21632823_ChIP-Seq_H3396_Human1.04121773
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03812449
136CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03310151
137OCT4_20526341_ChIP-Seq_ESCs_Human1.02936379
138IRF8_22096565_ChIP-ChIP_GC-B_Human1.02457041
139KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02370382
140SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02297738
141TP53_22573176_ChIP-Seq_HFKS_Human1.02278853
142RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02015176
143NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01945136
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01610482
145JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01515486
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01504758
147* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01164077
148JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01061719
149STAT3_23295773_ChIP-Seq_U87_Human1.00632591
150UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00153614
151SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99950225
152TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99469453
153FOXH1_21741376_ChIP-Seq_EPCs_Human0.99012229
154HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98444379
155POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98237202
156KLF5_25053715_ChIP-Seq_YYC3_Human0.97539223
157SMAD4_21741376_ChIP-Seq_EPCs_Human0.97318912
158GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97031162
159CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96827465
160TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96332387
161TCF4_23295773_ChIP-Seq_U87_Human0.96078577
162JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95723077
163SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95613510
164AR_25329375_ChIP-Seq_VCAP_Human0.95437790
165OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95026992
166ELK3_25401928_ChIP-Seq_HUVEC_Human0.94227693
167SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94033301
168SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93974812
169FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93823982
170NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92526871
171KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91099107
172* HNF4A_19822575_ChIP-Seq_HepG2_Human0.90614785
173CJUN_26792858_Chip-Seq_BT549_Human0.89359555
174JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86059550
175FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85546225
176MYC_18555785_ChIP-Seq_MESCs_Mouse0.85536564
177ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85336583
178NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84896239
179EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.83768138
180LXR_22292898_ChIP-Seq_THP-1_Human0.83698799
181TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83248043
182SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82790831
183TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82672016
184TP63_22573176_ChIP-Seq_HFKS_Human0.82264079
185MYC_19079543_ChIP-ChIP_MESCs_Mouse0.80199483
186ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79759252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.28988253
2MP0003705_abnormal_hypodermis_morpholog3.74555455
3MP0005275_abnormal_skin_tensile3.26300513
4MP0002876_abnormal_thyroid_physiology3.23514291
5MP0001666_abnormal_nutrient_absorption3.18819118
6MP0002139_abnormal_hepatobiliary_system3.09363655
7MP0010234_abnormal_vibrissa_follicle2.92063872
8MP0005646_abnormal_pituitary_gland2.87034860
9MP0008438_abnormal_cutaneous_collagen2.80495340
10MP0002796_impaired_skin_barrier2.71173397
11MP0003806_abnormal_nucleotide_metabolis2.69647345
12MP0003646_muscle_fatigue2.56550443
13MP0005085_abnormal_gallbladder_physiolo2.54251487
14MP0002254_reproductive_system_inflammat2.46734341
15MP0009780_abnormal_chondrocyte_physiolo2.42255505
16MP0010352_gastrointestinal_tract_polyps2.37232477
17MP0005365_abnormal_bile_salt2.29293257
18MP0002837_dystrophic_cardiac_calcinosis2.27530892
19MP0004885_abnormal_endolymph2.23540841
20MP0003252_abnormal_bile_duct2.09360096
21MP0005551_abnormal_eye_electrophysiolog1.87654489
22MP0002060_abnormal_skin_morphology1.87600763
23MP0008875_abnormal_xenobiotic_pharmacok1.84394662
24MP0008872_abnormal_physiological_respon1.84346099
25MP0006292_abnormal_olfactory_placode1.84224408
26MP0005501_abnormal_skin_physiology1.79476570
27MP0009053_abnormal_anal_canal1.78471761
28MP0002102_abnormal_ear_morphology1.75371789
29MP0002098_abnormal_vibrissa_morphology1.75139015
30MP0001849_ear_inflammation1.70801300
31MP0005377_hearing/vestibular/ear_phenot1.67873067
32MP0003878_abnormal_ear_physiology1.67873067
33MP0003566_abnormal_cell_adhesion1.66536258
34MP0010329_abnormal_lipoprotein_level1.66520506
35MP0000372_irregular_coat_pigmentation1.65635348
36MP0003941_abnormal_skin_development1.63739802
37MP0004264_abnormal_extraembryonic_tissu1.60322698
38MP0001485_abnormal_pinna_reflex1.57286087
39MP0004019_abnormal_vitamin_homeostasis1.55793934
40MP0003011_delayed_dark_adaptation1.55313589
41MP0006054_spinal_hemorrhage1.53802678
42MP0008775_abnormal_heart_ventricle1.50877354
43MP0009840_abnormal_foam_cell1.45937584
44MP0005257_abnormal_intraocular_pressure1.44295047
45MP0002138_abnormal_hepatobiliary_system1.43330923
46MP0005367_renal/urinary_system_phenotyp1.41206158
47MP0000516_abnormal_urinary_system1.41206158
48MP0004043_abnormal_pH_regulation1.37045911
49MP0005389_reproductive_system_phenotype1.35806498
50MP0005670_abnormal_white_adipose1.34501359
51MP0004145_abnormal_muscle_electrophysio1.32506326
52MP0000579_abnormal_nail_morphology1.32420390
53MP0006072_abnormal_retinal_apoptosis1.30158649
54MP0005023_abnormal_wound_healing1.27943143
55MP0002938_white_spotting1.27186414
56MP0004272_abnormal_basement_membrane1.26555477
57MP0003315_abnormal_perineum_morphology1.23286656
58MP0003283_abnormal_digestive_organ1.23110871
59MP0001968_abnormal_touch/_nociception1.22219247
60MP0003693_abnormal_embryo_hatching1.21731229
61MP0003879_abnormal_hair_cell1.21306931
62MP0003453_abnormal_keratinocyte_physiol1.19086532
63MP0001661_extended_life_span1.18959103
64MP0002282_abnormal_trachea_morphology1.17730670
65MP0001765_abnormal_ion_homeostasis1.17065455
66MP0000537_abnormal_urethra_morphology1.15128255
67MP0000467_abnormal_esophagus_morphology1.15080813
68MP0005636_abnormal_mineral_homeostasis1.12844939
69MP0005332_abnormal_amino_acid1.12316584
70MP0003638_abnormal_response/metabolism_1.10774410
71MP0009384_cardiac_valve_regurgitation1.10213614
72MP0001216_abnormal_epidermal_layer1.09833006
73MP0000750_abnormal_muscle_regeneration1.09241989
74MP0004147_increased_porphyrin_level1.08740108
75MP0000003_abnormal_adipose_tissue1.07110785
76MP0001764_abnormal_homeostasis1.07090713
77MP0000049_abnormal_middle_ear1.05411525
78MP0009643_abnormal_urine_homeostasis1.05285372
79MP0002089_abnormal_postnatal_growth/wei1.04355283
80MP0005220_abnormal_exocrine_pancreas1.03938315
81MP0005503_abnormal_tendon_morphology1.03747782
82MP0002736_abnormal_nociception_after1.02733262
83MP0003195_calcinosis1.02707613
84MP0010678_abnormal_skin_adnexa1.01655264
85MP0005076_abnormal_cell_differentiation1.01031920
86MP0000377_abnormal_hair_follicle0.98334577
87MP0002896_abnormal_bone_mineralization0.98245758
88MP0003300_gastrointestinal_ulcer0.96914072
89MP0001243_abnormal_dermal_layer0.96347688
90MP0005319_abnormal_enzyme/_coenzyme0.93886573
91MP0002118_abnormal_lipid_homeostasis0.93213187
92MP0010030_abnormal_orbit_morphology0.92926520
93MP0000230_abnormal_systemic_arterial0.92837031
94MP0005410_abnormal_fertilization0.92767262
95MP0003191_abnormal_cellular_cholesterol0.91770598
96MP0005075_abnormal_melanosome_morpholog0.90415826
97MP0004133_heterotaxia0.90322142
98MP0001664_abnormal_digestion0.90022042
99MP0001958_emphysema0.89970140
100MP0001919_abnormal_reproductive_system0.89677281
101MP0005647_abnormal_sex_gland0.88293356
102MP0002269_muscular_atrophy0.87383641
103MP0003868_abnormal_feces_composition0.86311054
104MP0000609_abnormal_liver_physiology0.86300905
105MP0010771_integument_phenotype0.85838441
106MP0004185_abnormal_adipocyte_glucose0.85462166
107MP0000631_abnormal_neuroendocrine_gland0.84873173
108MP0005083_abnormal_biliary_tract0.83882227
109MP0003718_maternal_effect0.82889353
110MP0000647_abnormal_sebaceous_gland0.81915692
111MP0005174_abnormal_tail_pigmentation0.81542157
112MP0000462_abnormal_digestive_system0.81410612
113MP0000383_abnormal_hair_follicle0.81281179
114MP0005253_abnormal_eye_physiology0.81200823
115MP0000613_abnormal_salivary_gland0.80990705
116MP0005666_abnormal_adipose_tissue0.80545081
117MP0000026_abnormal_inner_ear0.79883371
118MP0000477_abnormal_intestine_morphology0.78804194
119MP0001756_abnormal_urination0.78324246
120MP0000013_abnormal_adipose_tissue0.77654707
121MP0005375_adipose_tissue_phenotype0.77337388
122MP0004130_abnormal_muscle_cell0.76783894
123MP0002909_abnormal_adrenal_gland0.76124470
124MP0000678_abnormal_parathyroid_gland0.75897893
125MP0004381_abnormal_hair_follicle0.75287083
126MP0005623_abnormal_meninges_morphology0.75279902
127MP0004782_abnormal_surfactant_physiolog0.75257255
128MP0003938_abnormal_ear_development0.72616767
129MP0005451_abnormal_body_composition0.72570277
130MP0005408_hypopigmentation0.72386021
131MP0002249_abnormal_larynx_morphology0.71748998
132MP0003119_abnormal_digestive_system0.71710122
133MP0002136_abnormal_kidney_physiology0.71652328
134MP0003937_abnormal_limbs/digits/tail_de0.70329069
135MP0005448_abnormal_energy_balance0.69853840
136MP0004947_skin_inflammation0.69213522
137MP0002877_abnormal_melanocyte_morpholog0.69178530
138MP0000566_synostosis0.69151441
139MP0000639_abnormal_adrenal_gland0.66703280
140MP0000427_abnormal_hair_cycle0.66568369
141MP0001873_stomach_inflammation0.66484774
142MP0005084_abnormal_gallbladder_morpholo0.66299166
143MP0010386_abnormal_urinary_bladder0.66172653
144MP0008004_abnormal_stomach_pH0.65923140
145MP0005395_other_phenotype0.65900440
146MP0001963_abnormal_hearing_physiology0.65877383
147MP0002234_abnormal_pharynx_morphology0.65726268
148MP0003953_abnormal_hormone_level0.65341076
149MP0002160_abnormal_reproductive_system0.65059497
150MP0003950_abnormal_plasma_membrane0.64681078
151MP0003279_aneurysm0.64472130
152MP0000749_muscle_degeneration0.64280834
153MP0000538_abnormal_urinary_bladder0.63806983
154MP0008789_abnormal_olfactory_epithelium0.63626551
155MP0001730_embryonic_growth_arrest0.62524678
156MP0003136_yellow_coat_color0.62322393

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.88509965
2Malnutrition (HP:0004395)3.83870784
3Hyperglycinuria (HP:0003108)3.81531372
4Abnormality of the nasal septum (HP:0000419)3.67942431
5Premature rupture of membranes (HP:0001788)3.65047584
6Congenital stationary night blindness (HP:0007642)3.63041716
7Abnormality of the proximal phalanges of the hand (HP:0009834)3.57110557
8Protrusio acetabuli (HP:0003179)3.41156512
9Ileus (HP:0002595)3.40486017
10Congenital sensorineural hearing impairment (HP:0008527)3.34355271
11Abnormality of glutamine family amino acid metabolism (HP:0010902)3.32781456
12Xanthomatosis (HP:0000991)3.24730325
13Increased connective tissue (HP:0009025)3.21165904
14Alopecia of scalp (HP:0002293)3.17652168
15Pancreatic cysts (HP:0001737)3.17556442
16Abolished electroretinogram (ERG) (HP:0000550)3.14373288
17Pendular nystagmus (HP:0012043)3.12098426
18Increased corneal curvature (HP:0100692)3.11254630
19Keratoconus (HP:0000563)3.11254630
20Woolly hair (HP:0002224)3.10965783
21Abnormality of monocarboxylic acid metabolism (HP:0010996)3.08330433
22Abnormality of the renal cortex (HP:0011035)3.02590552
23Fragile skin (HP:0001030)3.00634259
24Pigmentary retinal degeneration (HP:0001146)2.92297303
25Renal cortical cysts (HP:0000803)2.91488475
26Hypobetalipoproteinemia (HP:0003563)2.84682762
27Abnormality of serine family amino acid metabolism (HP:0010894)2.84643749
28Abnormality of glycine metabolism (HP:0010895)2.84643749
29Abnormality of the middle phalanges of the toes (HP:0010183)2.82311971
30Abnormality of proline metabolism (HP:0010907)2.78752492
31Hydroxyprolinuria (HP:0003080)2.78752492
32Atrophic scars (HP:0001075)2.73491303
33Hypolipoproteinemia (HP:0010981)2.72179343
34Intrahepatic cholestasis (HP:0001406)2.71879784
35Onycholysis (HP:0001806)2.71654493
36True hermaphroditism (HP:0010459)2.69939269
37Morphological abnormality of the middle ear (HP:0008609)2.69256272
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.68316985
39Congenital, generalized hypertrichosis (HP:0004540)2.63887501
40Hypoplasia of the uterus (HP:0000013)2.61482323
41Attenuation of retinal blood vessels (HP:0007843)2.60041050
42Pancreatic fibrosis (HP:0100732)2.59747497
43Decreased central vision (HP:0007663)2.56668466
44Hypoalphalipoproteinemia (HP:0003233)2.55637887
45Chorioretinal atrophy (HP:0000533)2.53178115
46Methylmalonic acidemia (HP:0002912)2.52101716
47Cerebral aneurysm (HP:0004944)2.50431949
48Hyperglycinemia (HP:0002154)2.50024646
49Abnormality of the 1st metacarpal (HP:0010009)2.49915160
50Prolonged partial thromboplastin time (HP:0003645)2.48775313
51Ventricular tachycardia (HP:0004756)2.45282962
52Mildly elevated creatine phosphokinase (HP:0008180)2.45140476
53Milia (HP:0001056)2.44904566
54Type 1 muscle fiber predominance (HP:0003803)2.43055578
55Abnormal rod and cone electroretinograms (HP:0008323)2.42633601
56Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.42603315
57Nephronophthisis (HP:0000090)2.41724656
58Decreased circulating renin level (HP:0003351)2.40599218
59Ketosis (HP:0001946)2.40481973
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40368274
61Back pain (HP:0003418)2.35426018
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35329090
63Abnormality of alanine metabolism (HP:0010916)2.35329090
64Hyperalaninemia (HP:0003348)2.35329090
65Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34384806
66Methylmalonic aciduria (HP:0012120)2.33595403
67Pili torti (HP:0003777)2.33341208
68Abnormality of the costochondral junction (HP:0000919)2.31861846
69Aortic dissection (HP:0002647)2.31528281
70Distal lower limb muscle weakness (HP:0009053)2.29495962
71Enlarged kidneys (HP:0000105)2.28152562
72Aplasia/hypoplasia of the uterus (HP:0008684)2.26676899
73Furrowed tongue (HP:0000221)2.25667212
74Difficulty climbing stairs (HP:0003551)2.25537508
75Abnormality of vitamin B metabolism (HP:0004340)2.24724402
76Hyporeflexia of lower limbs (HP:0002600)2.23705394
77Cystic liver disease (HP:0006706)2.23458197
78Confusion (HP:0001289)2.23413568
79Ankle contracture (HP:0006466)2.22640090
80Fat malabsorption (HP:0002630)2.22615832
81Hyperglycemia (HP:0003074)2.19858593
82Abnormality of midbrain morphology (HP:0002418)2.19541422
83Molar tooth sign on MRI (HP:0002419)2.19541422
84Hypoglycemic coma (HP:0001325)2.18397257
85Abnormality of the vitamin B12 metabolism (HP:0004341)2.18209474
86Hyperlipoproteinemia (HP:0010980)2.17835413
87Abnormality of the renal medulla (HP:0100957)2.17675315
88Short 1st metacarpal (HP:0010034)2.16737161
89Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.16737161
90Plantar hyperkeratosis (HP:0007556)2.16564473
91Pterygium (HP:0001059)2.15294565
92Stenosis of the external auditory canal (HP:0000402)2.14311003
93Neonatal short-limb short stature (HP:0008921)2.13724773
94Increased IgE level (HP:0003212)2.09801933
95Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.09316460
96Hypotrichosis (HP:0001006)2.07549729
97Short hallux (HP:0010109)2.07458399
98Abnormality of the renal collecting system (HP:0004742)2.06491687
99Flat acetabular roof (HP:0003180)2.06193550
100Gastrointestinal dysmotility (HP:0002579)2.06128727
101Short femoral neck (HP:0100864)2.05716695
102Symphalangism affecting the phalanges of the hand (HP:0009773)2.02982052
103Myopathic facies (HP:0002058)2.02773077
104Concave nail (HP:0001598)2.02746535
105Fused cervical vertebrae (HP:0002949)2.01399210
106Tubular atrophy (HP:0000092)2.00488924
107Aplasia/Hypoplasia of the spleen (HP:0010451)2.00078196
108Ketoacidosis (HP:0001993)1.99805712
109Nail dystrophy (HP:0008404)1.98684297
110Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.97868555
111Glycosuria (HP:0003076)1.97546978
112Abnormality of urine glucose concentration (HP:0011016)1.97546978
113Esophageal varix (HP:0002040)1.95534883
114Popliteal pterygium (HP:0009756)1.95494650
115Abnormality of vitamin metabolism (HP:0100508)1.94873752
116Widely patent fontanelles and sutures (HP:0004492)1.94866991
117Asplenia (HP:0001746)1.94810054
118Cupped ribs (HP:0000887)1.93576486
119Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93538730
120Hypoplasia of the fovea (HP:0007750)1.93394814
121Aplasia/Hypoplasia of the fovea (HP:0008060)1.93394814
122Curly hair (HP:0002212)1.92937575
123Deep venous thrombosis (HP:0002625)1.91934145
124Abnormal cartilage morphology (HP:0002763)1.91835040
125Abnormality of purine metabolism (HP:0004352)1.91822599
126Epidermoid cyst (HP:0200040)1.90358035
127Short phalanx of the thumb (HP:0009660)1.90252285
128Delayed CNS myelination (HP:0002188)1.88933904
129Conjunctival hamartoma (HP:0100780)1.88555330
130Breech presentation (HP:0001623)1.88136205
131Abnormality of the phalanges of the 5th finger (HP:0004213)1.87991465
132Aplasia/Hypoplasia of the hallux (HP:0008362)1.87792997
133Abnormality of serum amino acid levels (HP:0003112)1.87704872
134Alkalosis (HP:0001948)1.87583555
135Hyperammonemia (HP:0001987)1.87377271
136Muscle fiber splitting (HP:0003555)1.87056227
137Aortic aneurysm (HP:0004942)1.86981222
138Abnormal delivery (HP:0001787)1.86701333
139Synostosis of carpal bones (HP:0005048)1.86191244
140Large for gestational age (HP:0001520)1.86102130
141Metabolic acidosis (HP:0001942)1.85483376
142Hepatic necrosis (HP:0002605)1.85038803
143Cerebral palsy (HP:0100021)1.84472978
144Hamartoma of the eye (HP:0010568)1.84438612
145Palpitations (HP:0001962)1.82687716
146Short humerus (HP:0005792)1.82681231
147Type II lissencephaly (HP:0007260)1.82585342
148Aplasia/Hypoplasia involving the musculature (HP:0001460)1.82501734
149Palmoplantar hyperkeratosis (HP:0000972)1.82291861
150Fatigable weakness (HP:0003473)1.82192909
151Abnormality of the neuromuscular junction (HP:0003398)1.82192909
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.82056414
153Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.81731140
154Vascular calcification (HP:0004934)1.81398278
155Abdominal distention (HP:0003270)1.81396521
156Synostosis involving the elbow (HP:0003938)1.81004504
157Humeroradial synostosis (HP:0003041)1.81004504
158Thin bony cortex (HP:0002753)1.80545165
159Trismus (HP:0000211)1.79992983
160Carpal bone hypoplasia (HP:0001498)1.79864317
161Spontaneous abortion (HP:0005268)1.79701280
162Generalized aminoaciduria (HP:0002909)1.77739081
163Spinal rigidity (HP:0003306)1.77211621
164Dicarboxylic aciduria (HP:0003215)1.77211283
165Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77211283
166Wide cranial sutures (HP:0010537)1.77122169
167Metabolic alkalosis (HP:0200114)1.76832245
168Conjugated hyperbilirubinemia (HP:0002908)1.76616102
169Fragile nails (HP:0001808)1.73829037
170Dehydration (HP:0001944)1.73021455
171Abnormality of placental membranes (HP:0011409)1.71417682
172Amniotic constriction ring (HP:0009775)1.71417682
173Abnormal hemoglobin (HP:0011902)1.70642125
174Cardiovascular calcification (HP:0011915)1.70037164
175Palmar hyperkeratosis (HP:0010765)1.69509982
176Wrist flexion contracture (HP:0001239)1.69418910
177Abnormality of nail color (HP:0100643)1.68878612
178Ulnar bowing (HP:0003031)1.68831527
179Aneurysm (HP:0002617)1.68610631
180Muscle fiber inclusion bodies (HP:0100299)1.68481965
181Selective tooth agenesis (HP:0001592)1.67215626
182Abnormality of the intrinsic pathway (HP:0010989)1.66711786
183Aplasia/hypoplasia of the humerus (HP:0006507)1.66537692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.21042250
2EPHA23.92608411
3GRK13.72011168
4MUSK3.08875614
5ADRBK22.98297678
6LATS12.82202863
7MET2.63563453
8ACVR1B2.60493941
9PIK3CA2.59964461
10ERN12.55698074
11FRK2.47882326
12MAP4K22.38205953
13STK38L2.37315045
14MAPKAPK32.28475424
15TLK12.09455174
16TTN2.05943218
17BMPR1B2.04224744
18TAOK32.00133087
19TRIB31.99013856
20FER1.94652200
21MAP2K21.87099320
22EIF2AK11.81547246
23RPS6KB21.77482858
24TESK11.72181812
25MAP3K21.70108793
26EPHB21.67897773
27DDR21.63554035
28LATS21.59997252
29FGFR21.59785471
30STK391.58860490
31TXK1.57388105
32EEF2K1.54553633
33ZAK1.52310128
34SIK11.50449443
35BCKDK1.40837270
36MAP2K61.38655663
37LMTK21.37672133
38PIK3CG1.37292836
39MAP2K11.33970322
40WNK31.32359556
41NME11.30471003
42MAP3K31.27686397
43PTK21.27289228
44PDK31.26924524
45PDK41.26924524
46AKT31.24856991
47FGFR41.23537994
48MAP3K81.18810893
49PDK21.18683206
50PTK61.16752663
51RIPK11.16670718
52TESK21.14730649
53STK101.13489015
54PAK41.11280929
55PRKG21.10348330
56BUB11.10239440
57PHKG21.09966850
58PHKG11.09966850
59ADRBK11.09844561
60DYRK1B1.06565161
61PKN21.06330661
62IKBKB1.04627166
63FLT31.04180320
64MST41.04057499
65EIF2AK31.03999594
66PRKD21.02473393
67ERBB31.00250660
68PRKCE0.96858456
69OXSR10.95932156
70PDGFRA0.95147674
71PRKCI0.94267090
72GRK60.93954862
73MAPK130.93947223
74MAP3K100.93704626
75PAK20.93524015
76ERBB20.92167301
77TRPM70.91288823
78NEK10.90186564
79ERBB40.87030349
80CSNK1G30.86623989
81MTOR0.85874658
82TTK0.84231820
83MYLK0.83268931
84STK30.82886753
85CDK120.82074958
86LRRK20.81173603
87DYRK30.80638003
88NEK90.78445114
89MAPKAPK50.78180746
90CSNK1G10.74636813
91TGFBR10.72800914
92CSNK1G20.72717012
93LIMK10.71494622
94KSR20.71300525
95VRK20.69259145
96AURKB0.69083143
97PIM20.67397735
98KDR0.66345243
99PLK40.65269471
100KIT0.63708058
101CSNK1A1L0.63205025
102CSNK1A10.62354032
103OBSCN0.61585697
104MAPK110.61140584
105TGFBR20.61117759
106DAPK20.60323762
107CDK60.59884191
108ITK0.59156671
109STK160.59087363
110CDC42BPA0.58947896
111GRK50.57621869
112PINK10.56924921
113PAK30.56141387
114PTK2B0.54862414
115PRKAA10.54294300
116IGF1R0.53607655
117PLK20.52847373
118CHUK0.52772267
119ICK0.52705130
120PRKCG0.52246696
121PRKACA0.51871752
122CDK70.51557320
123MOS0.50537010
124EPHA30.50338757
125BMX0.49771025
126GRK70.49526652
127PRKCA0.48998526
128TIE10.48847237
129MAP3K110.47767114
130NEK20.46197299
131EPHB10.45001168
132ABL20.44701749
133FGFR10.43612678
134DAPK10.40794417
135ROCK10.40262330
136PAK10.40098478
137PRKD10.39781072
138PRKCZ0.39601698
139BRSK20.39326105
140AKT20.39109070
141PRKACG0.37511625
142INSRR0.37369873
143FGFR30.36995702
144PRKAA20.35907255
145ABL10.35864013
146MAP3K10.35509466
147CDK80.35405069
148PASK0.35327398
149RPS6KA40.35017809
150MAPKAPK20.34563324
151CAMK2A0.32911392
152CASK0.32266332
153MAPK150.32237811
154CAMK2D0.31976833
155RPS6KA60.31669404
156NUAK10.31608871
157PRKCQ0.31458934
158MAP3K120.30912032
159PLK10.30581519
160AURKA0.29612947
161CSNK1D0.28511002
162WNK40.27618028
163RPS6KA50.27100969
164TEC0.26852152
165CSNK2A10.26410000
166RPS6KA20.25784606

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049753.89608096
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.59505604
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.32678445
4Vitamin digestion and absorption_Homo sapiens_hsa049772.31655141
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26764082
6Mineral absorption_Homo sapiens_hsa049782.16039556
7Fatty acid degradation_Homo sapiens_hsa000712.13079924
8Sulfur metabolism_Homo sapiens_hsa009202.09709515
9Folate biosynthesis_Homo sapiens_hsa007902.06754666
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06443819
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01743467
12Caffeine metabolism_Homo sapiens_hsa002322.00925478
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.92052675
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.91755136
15Histidine metabolism_Homo sapiens_hsa003401.81754237
16PPAR signaling pathway_Homo sapiens_hsa033201.80788151
17Protein digestion and absorption_Homo sapiens_hsa049741.78445066
18Phototransduction_Homo sapiens_hsa047441.76104635
19Starch and sucrose metabolism_Homo sapiens_hsa005001.76025043
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73801376
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71416100
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.69198360
23Tryptophan metabolism_Homo sapiens_hsa003801.69196359
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68269971
25Selenocompound metabolism_Homo sapiens_hsa004501.65169735
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63718656
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63449411
28Renin-angiotensin system_Homo sapiens_hsa046141.62887070
29Arginine biosynthesis_Homo sapiens_hsa002201.61963016
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59692225
31Bile secretion_Homo sapiens_hsa049761.58160406
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53939701
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.50018763
34Glutathione metabolism_Homo sapiens_hsa004801.46478560
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46088384
36Carbon metabolism_Homo sapiens_hsa012001.45580284
37Fatty acid metabolism_Homo sapiens_hsa012121.44508576
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.44108096
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42908862
40Propanoate metabolism_Homo sapiens_hsa006401.42845933
41Biosynthesis of amino acids_Homo sapiens_hsa012301.39501102
42Nitrogen metabolism_Homo sapiens_hsa009101.39445389
43Galactose metabolism_Homo sapiens_hsa000521.38988335
44Fructose and mannose metabolism_Homo sapiens_hsa000511.38418991
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36822187
46Pyruvate metabolism_Homo sapiens_hsa006201.35776045
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34500191
48Linoleic acid metabolism_Homo sapiens_hsa005911.34257656
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28606250
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.27304462
51Ether lipid metabolism_Homo sapiens_hsa005651.27241730
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.25933593
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22705794
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21621245
55Fatty acid biosynthesis_Homo sapiens_hsa000611.19933602
56Chemical carcinogenesis_Homo sapiens_hsa052041.17444462
57beta-Alanine metabolism_Homo sapiens_hsa004101.13041009
58Phenylalanine metabolism_Homo sapiens_hsa003601.11429398
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08857893
60ECM-receptor interaction_Homo sapiens_hsa045121.07594507
61Arginine and proline metabolism_Homo sapiens_hsa003301.05185225
62Oxidative phosphorylation_Homo sapiens_hsa001901.03007250
63Bladder cancer_Homo sapiens_hsa052191.02625279
64Adherens junction_Homo sapiens_hsa045201.02092065
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.01925989
66* Glycerolipid metabolism_Homo sapiens_hsa005611.01358537
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99238572
68Peroxisome_Homo sapiens_hsa041460.97411437
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.97364316
70Complement and coagulation cascades_Homo sapiens_hsa046100.96368319
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95626550
72Arachidonic acid metabolism_Homo sapiens_hsa005900.94097171
73One carbon pool by folate_Homo sapiens_hsa006700.94011986
74Pentose phosphate pathway_Homo sapiens_hsa000300.93805952
75Tight junction_Homo sapiens_hsa045300.91953248
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90361343
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85349362
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82113737
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.77092287
80Thyroid cancer_Homo sapiens_hsa052160.76438045
81Steroid biosynthesis_Homo sapiens_hsa001000.74636256
82Retinol metabolism_Homo sapiens_hsa008300.70304528
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.70214156
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69106798
85Tyrosine metabolism_Homo sapiens_hsa003500.67680972
86Sulfur relay system_Homo sapiens_hsa041220.65958761
87ABC transporters_Homo sapiens_hsa020100.65122563
88Ovarian steroidogenesis_Homo sapiens_hsa049130.61490546
89Homologous recombination_Homo sapiens_hsa034400.60359100
90Butanoate metabolism_Homo sapiens_hsa006500.58652675
91Protein export_Homo sapiens_hsa030600.56004935
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55059330
93Parkinsons disease_Homo sapiens_hsa050120.53579249
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53513710
95Focal adhesion_Homo sapiens_hsa045100.52684992
96Taste transduction_Homo sapiens_hsa047420.51598372
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51217259
98Pancreatic secretion_Homo sapiens_hsa049720.50668453
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50593699
100Insulin secretion_Homo sapiens_hsa049110.50006914
101p53 signaling pathway_Homo sapiens_hsa041150.49739477
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49705261
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48481293
104Hippo signaling pathway_Homo sapiens_hsa043900.47565361
105TGF-beta signaling pathway_Homo sapiens_hsa043500.47489510
106Vitamin B6 metabolism_Homo sapiens_hsa007500.47310986
107Nicotine addiction_Homo sapiens_hsa050330.45033080
108Alzheimers disease_Homo sapiens_hsa050100.43187371
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42622322
110Proteoglycans in cancer_Homo sapiens_hsa052050.42204398
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41215234
112* Metabolic pathways_Homo sapiens_hsa011000.40894939
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40354813
114Olfactory transduction_Homo sapiens_hsa047400.39282846
115Lysine degradation_Homo sapiens_hsa003100.39190383
116Proteasome_Homo sapiens_hsa030500.39061442
117Asthma_Homo sapiens_hsa053100.37866877
118Amoebiasis_Homo sapiens_hsa051460.37303973
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37187675
120Sphingolipid metabolism_Homo sapiens_hsa006000.37132246
121Cardiac muscle contraction_Homo sapiens_hsa042600.36803164
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.35153705
123Salivary secretion_Homo sapiens_hsa049700.34116105
124Serotonergic synapse_Homo sapiens_hsa047260.33669903
125RNA polymerase_Homo sapiens_hsa030200.31777182
126RNA degradation_Homo sapiens_hsa030180.31260045
127* Glycerophospholipid metabolism_Homo sapiens_hsa005640.30788229
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27085978
129Small cell lung cancer_Homo sapiens_hsa052220.25855941
130Thyroid hormone synthesis_Homo sapiens_hsa049180.25356134
131N-Glycan biosynthesis_Homo sapiens_hsa005100.24484116
132Fanconi anemia pathway_Homo sapiens_hsa034600.24454000
133Insulin resistance_Homo sapiens_hsa049310.23383024
134Fatty acid elongation_Homo sapiens_hsa000620.22994036
135Dilated cardiomyopathy_Homo sapiens_hsa054140.19826584

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