LPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)7.99083205
2* regulation of sequestering of triglyceride (GO:0010889)7.45596595
3brown fat cell differentiation (GO:0050873)5.82004113
4valine metabolic process (GO:0006573)5.64405450
5white fat cell differentiation (GO:0050872)5.25574016
6* regulation of cholesterol storage (GO:0010885)5.19934102
7fatty acid transmembrane transport (GO:1902001)5.15306476
8* triglyceride catabolic process (GO:0019433)4.72224954
9positive regulation of fatty acid oxidation (GO:0046321)4.58236919
10negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.51983553
11cGMP-mediated signaling (GO:0019934)4.45919242
12carnitine shuttle (GO:0006853)4.40495632
13fatty acid beta-oxidation (GO:0006635)4.37706148
14tricarboxylic acid cycle (GO:0006099)4.28674349
15lipid storage (GO:0019915)4.24920188
16lipid particle organization (GO:0034389)4.17969989
17* neutral lipid catabolic process (GO:0046461)4.15149614
18* acylglycerol catabolic process (GO:0046464)4.15149614
19biotin metabolic process (GO:0006768)4.14148750
20negative regulation of lipid storage (GO:0010888)4.10766055
21diacylglycerol metabolic process (GO:0046339)4.00315117
22* positive regulation of lipid storage (GO:0010884)3.98833412
23regulation of fatty acid oxidation (GO:0046320)3.98746398
24branched-chain amino acid metabolic process (GO:0009081)3.97582561
25branched-chain amino acid catabolic process (GO:0009083)3.96937825
26positive regulation of fatty acid beta-oxidation (GO:0032000)3.94753727
27regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.84294037
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.83646865
29response to epinephrine (GO:0071871)3.82937978
30fatty acid oxidation (GO:0019395)3.79137950
31transcytosis (GO:0045056)3.78082940
32positive regulation of macrophage cytokine production (GO:0060907)3.77662850
33lipid oxidation (GO:0034440)3.74689254
34response to dietary excess (GO:0002021)3.70703016
35phagocytosis, recognition (GO:0006910)3.67284736
36polyol transport (GO:0015791)3.66011647
37fatty acid catabolic process (GO:0009062)3.62030768
38plasma lipoprotein particle clearance (GO:0034381)3.57575768
39regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.57326000
40CDP-diacylglycerol biosynthetic process (GO:0016024)3.57248664
41positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.56264287
42NADH metabolic process (GO:0006734)3.53796170
43* regulation of lipid storage (GO:0010883)3.49482552
44positive regulation of sterol transport (GO:0032373)3.49469193
45positive regulation of cholesterol transport (GO:0032376)3.49469193
46carnitine transmembrane transport (GO:1902603)3.48119057
47regulation of gonadotropin secretion (GO:0032276)3.47155019
48barbed-end actin filament capping (GO:0051016)3.45510413
49regulation of acyl-CoA biosynthetic process (GO:0050812)3.45292385
50tricarboxylic acid metabolic process (GO:0072350)3.44712431
51positive regulation of glomerulus development (GO:0090193)3.42626370
52positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.42449231
53CDP-diacylglycerol metabolic process (GO:0046341)3.40297213
54modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.38609812
55positive regulation by organism of defense response of other organism involved in symbiotic interact3.38609812
56modulation by symbiont of host immune response (GO:0052553)3.38609812
57positive regulation by symbiont of host defense response (GO:0052509)3.38609812
58modulation by symbiont of host defense response (GO:0052031)3.38609812
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.38609812
60lipoprotein transport (GO:0042953)3.36247417
61regulation of cAMP-dependent protein kinase activity (GO:2000479)3.35163874
62intracellular lipid transport (GO:0032365)3.29683057
63* regulation of macrophage derived foam cell differentiation (GO:0010743)3.27998395
64regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.26475440
65retina vasculature morphogenesis in camera-type eye (GO:0061299)3.26349558
66regulation of cofactor metabolic process (GO:0051193)3.25741753
67regulation of coenzyme metabolic process (GO:0051196)3.25741753
68amino-acid betaine transport (GO:0015838)3.24667325
69carnitine transport (GO:0015879)3.24667325
70cellular response to zinc ion (GO:0071294)3.24586743
71detection of calcium ion (GO:0005513)3.24551853
72apoptotic cell clearance (GO:0043277)3.24513928
73phospholipid homeostasis (GO:0055091)3.24161242
74* triglyceride metabolic process (GO:0006641)3.21728895
75protein heterotrimerization (GO:0070208)3.20388358
76regulation of glycogen (starch) synthase activity (GO:2000465)3.19663649
77negative regulation of granulocyte differentiation (GO:0030853)3.19553750
78cellular response to lithium ion (GO:0071285)3.15402703
792-oxoglutarate metabolic process (GO:0006103)3.12637821
80fatty-acyl-CoA biosynthetic process (GO:0046949)3.10786833
81ethanol oxidation (GO:0006069)3.10682798
82fatty-acyl-CoA metabolic process (GO:0035337)3.09084823
83positive regulation of lipid catabolic process (GO:0050996)3.09016616
84positive regulation of fatty acid metabolic process (GO:0045923)3.08289362
85negative regulation of macrophage differentiation (GO:0045650)3.05468065
86positive regulation of lipoprotein lipase activity (GO:0051006)3.04203105
87positive regulation of triglyceride lipase activity (GO:0061365)3.04203105
88regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.03910368
89regulation of fatty acid beta-oxidation (GO:0031998)3.00846503
90regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.99721155
91response to lipoprotein particle (GO:0055094)2.99388393
92negative regulation of protein autophosphorylation (GO:0031953)2.99081953
93regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.99033378
94* acylglycerol metabolic process (GO:0006639)2.98204433
95positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.98163489
96ovulation from ovarian follicle (GO:0001542)2.97802935
97* glycerolipid catabolic process (GO:0046503)2.95280775
98phosphatidic acid metabolic process (GO:0046473)2.94618811
99phosphatidic acid biosynthetic process (GO:0006654)2.94618811
100* neutral lipid metabolic process (GO:0006638)2.93235015
101negative regulation of norepinephrine secretion (GO:0010700)2.93234073
102activation of protein kinase A activity (GO:0034199)2.93005656
103cardiac muscle contraction (GO:0060048)2.92930551
104long-chain fatty acid transport (GO:0015909)2.92921545
105negative regulation of amino acid transport (GO:0051956)2.90924861
106response to phenylpropanoid (GO:0080184)2.85234734
107positive regulation of cellular response to insulin stimulus (GO:1900078)2.84231925
108cellular response to epinephrine stimulus (GO:0071872)2.83441095
109* triglyceride biosynthetic process (GO:0019432)2.82654886
110endothelium development (GO:0003158)2.82610328
111cAMP biosynthetic process (GO:0006171)2.80551666
112oxaloacetate metabolic process (GO:0006107)2.78792047
113acetyl-CoA metabolic process (GO:0006084)2.74637339
114growth hormone receptor signaling pathway (GO:0060396)2.74240370
115acyl-CoA biosynthetic process (GO:0071616)2.73386908
116thioester biosynthetic process (GO:0035384)2.73386908
117cardiac myofibril assembly (GO:0055003)2.73327404
118acyl-CoA metabolic process (GO:0006637)2.72425839
119thioester metabolic process (GO:0035383)2.72425839
120creatine metabolic process (GO:0006600)2.71861035
121positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.71554014
122long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.71504636
123negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.71500004
124succinate metabolic process (GO:0006105)2.70604405
125regulation of receptor binding (GO:1900120)2.70413149
126monocarboxylic acid catabolic process (GO:0072329)2.70277320
127regulation of macrophage cytokine production (GO:0010935)2.70035687
128positive regulation of p38MAPK cascade (GO:1900745)2.69171548
129cellular response to vitamin (GO:0071295)2.68518124
130* neutral lipid biosynthetic process (GO:0046460)2.68137219
131* acylglycerol biosynthetic process (GO:0046463)2.68137219
132negative regulation of phagocytosis (GO:0050765)2.67034901
133cellular response to monoamine stimulus (GO:0071868)2.66485616
134cellular response to catecholamine stimulus (GO:0071870)2.66485616
135regulation of interferon-beta biosynthetic process (GO:0045357)2.66402880
136plasma membrane repair (GO:0001778)2.66322223
137sarcomere organization (GO:0045214)2.66250065
138negative regulation of smooth muscle cell proliferation (GO:0048662)2.65272037
139cell migration involved in heart development (GO:0060973)2.65205559
140fatty acid homeostasis (GO:0055089)2.65051440
141alpha-linolenic acid metabolic process (GO:0036109)2.64309109
142regulation of cell communication by electrical coupling (GO:0010649)2.63541487
143keratan sulfate catabolic process (GO:0042340)2.62932004
144regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.61686858
145regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.61154982
146negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.60856443
147regulation of triglyceride catabolic process (GO:0010896)2.60839731
148positive regulation of interferon-alpha production (GO:0032727)2.60595859
149positive regulation of cholesterol efflux (GO:0010875)2.60359271
150pentose-phosphate shunt (GO:0006098)2.59312778
151fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.58664956
152NADPH regeneration (GO:0006740)2.58510739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse5.48565934
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.84329152
3CLOCK_20551151_ChIP-Seq_293T_Human3.34344114
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.17933143
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.93415679
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.75056483
7EZH2_22144423_ChIP-Seq_EOC_Human2.41986127
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.37232010
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29183402
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23611404
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.18800307
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16456911
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.15768320
14* LXR_22158963_ChIP-Seq_LIVER_Mouse2.12650267
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11953713
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.04904182
17* PPARG_19300518_ChIP-PET_3T3-L1_Mouse10.9290051
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.91098594
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90216254
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84742362
21PPARA_22158963_ChIP-Seq_LIVER_Mouse1.84632922
22* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.83412763
23GATA1_22025678_ChIP-Seq_K562_Human1.82936974
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82650822
25* TBX20_22328084_ChIP-Seq_HEART_Mouse1.81889632
26* TBX20_22080862_ChIP-Seq_HEART_Mouse1.81889632
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80615165
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78862749
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.75710661
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74401875
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73045956
32PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.72611344
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72428332
34VDR_24787735_ChIP-Seq_THP-1_Human1.64479784
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.64124252
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58838580
37* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.58512589
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54404074
39* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53991993
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52428543
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51718273
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.48307449
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47732869
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45778359
45* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44439114
46* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44439114
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44100114
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44037803
49* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38546972
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37743077
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35530630
52* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33823907
53* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32914685
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32583931
55* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32242140
56* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31926787
57* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31926787
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31079446
59CJUN_26792858_Chip-Seq_BT549_Human1.29821963
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.28140915
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25708011
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24476713
63* EED_16625203_ChIP-ChIP_MESCs_Mouse1.23812577
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21217210
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20344085
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.19974796
67SPI1_23127762_ChIP-Seq_K562_Human1.17532635
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07324282
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07202388
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06639837
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06011220
72SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04498179
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04102118
74* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02940756
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01690363
76* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00313273
77ESR2_21235772_ChIP-Seq_MCF-7_Human0.98856340
78HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98559873
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98104853
80GATA1_19941826_ChIP-Seq_K562_Human0.96984320
81KDM2B_26808549_Chip-Seq_K562_Human0.94411962
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93609514
83NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93395781
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92691903
85VDR_24763502_ChIP-Seq_THP-1_Human0.91171388
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90925294
87RUNX_20019798_ChIP-Seq_JUKART_Human0.90309277
88JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90008369
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89193141
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.88819942
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.88609917
92SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88245714
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88026962
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87921943
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87808765
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87606525
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87410503
98* SA1_22415368_ChIP-Seq_MEFs_Mouse0.86990000
99SOX2_20726797_ChIP-Seq_SW620_Human0.86896136
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86794831
101P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86780872
102GATA2_19941826_ChIP-Seq_K562_Human0.85301478
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85209866
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85052295
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84979930
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84417777
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83138691
108SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82757772
109TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82385913
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81645364
111PU_27001747_Chip-Seq_BMDM_Mouse0.81609159
112STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.80756663
113FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80227440
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80197986
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80020793
116LXR_22292898_ChIP-Seq_THP-1_Human0.79605572
117WT1_19549856_ChIP-ChIP_CCG9911_Human0.79534154
118SMC1_22415368_ChIP-Seq_MEFs_Mouse0.79471785
119P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79416972
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79151902
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.79066659
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78267364
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77299926
124RXR_22108803_ChIP-Seq_LS180_Human0.77211595
125* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77150133
126ZNF263_19887448_ChIP-Seq_K562_Human0.77070327
127GBX2_23144817_ChIP-Seq_PC3_Human0.76868871
128ESR1_21235772_ChIP-Seq_MCF-7_Human0.74556780
129GATA4_21415370_ChIP-Seq_HL-1_Mouse0.74545668
130FOXA2_19822575_ChIP-Seq_HepG2_Human0.74053060
131SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73331509
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72317715
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.70946725
134KDM2B_26808549_Chip-Seq_DND41_Human0.70259816
135TP53_20018659_ChIP-ChIP_R1E_Mouse0.69391262
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.69302266
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.68069017
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.67332080
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.67130258
140PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66795174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.57385688
2* MP0004130_abnormal_muscle_cell4.47170371
3MP0004185_abnormal_adipocyte_glucose4.14823355
4MP0005666_abnormal_adipose_tissue4.11175654
5MP0002837_dystrophic_cardiac_calcinosis4.03360449
6MP0008438_abnormal_cutaneous_collagen3.68454403
7MP0003646_muscle_fatigue3.11322488
8* MP0005375_adipose_tissue_phenotype2.75949862
9MP0002971_abnormal_brown_adipose2.40544796
10MP0003191_abnormal_cellular_cholesterol2.37799082
11MP0000751_myopathy2.35562203
12MP0003828_pulmonary_edema2.21913958
13MP0000013_abnormal_adipose_tissue2.21786819
14MP0004084_abnormal_cardiac_muscle2.16345769
15MP0005058_abnormal_lysosome_morphology2.11259862
16MP0003724_increased_susceptibility_to2.06156380
17MP0005275_abnormal_skin_tensile2.02493181
18MP0009115_abnormal_fat_cell1.97261615
19MP0004215_abnormal_myocardial_fiber1.90973277
20MP0003705_abnormal_hypodermis_morpholog1.86791866
21MP0003011_delayed_dark_adaptation1.86735879
22MP0000343_altered_response_to1.85277713
23MP0005330_cardiomyopathy1.82322656
24MP0003221_abnormal_cardiomyocyte_apopto1.70320385
25MP0000750_abnormal_muscle_regeneration1.69007662
26* MP0005334_abnormal_fat_pad1.67500148
27MP0004087_abnormal_muscle_fiber1.66729355
28* MP0001544_abnormal_cardiovascular_syste1.63994127
29* MP0005385_cardiovascular_system_phenoty1.63994127
30MP0004036_abnormal_muscle_relaxation1.60642375
31MP0003690_abnormal_glial_cell1.58402140
32* MP0002972_abnormal_cardiac_muscle1.57635294
33* MP0010329_abnormal_lipoprotein_level1.52833341
34* MP0000003_abnormal_adipose_tissue1.52531754
35MP0006138_congestive_heart_failure1.52490072
36* MP0008775_abnormal_heart_ventricle1.52310018
37MP0003137_abnormal_impulse_conducting1.49124055
38MP0005535_abnormal_body_temperature1.46854791
39MP0000749_muscle_degeneration1.44491834
40MP0001661_extended_life_span1.43678029
41MP0002970_abnormal_white_adipose1.41827887
42MP0003186_abnormal_redox_activity1.37689547
43* MP0005620_abnormal_muscle_contractility1.36280328
44* MP0002118_abnormal_lipid_homeostasis1.35865045
45MP0003436_decreased_susceptibility_to1.35018186
46MP0003303_peritoneal_inflammation1.34009488
47MP0005595_abnormal_vascular_smooth1.33585286
48MP0003329_amyloid_beta_deposits1.31472064
49MP0004272_abnormal_basement_membrane1.30143872
50MP0004510_myositis1.29860552
51MP0002332_abnormal_exercise_endurance1.29609314
52MP0004484_altered_response_of1.29246878
53MP0010630_abnormal_cardiac_muscle1.27972657
54MP0003566_abnormal_cell_adhesion1.27578600
55MP0003950_abnormal_plasma_membrane1.22786932
56MP0003959_abnormal_lean_body1.21830107
57MP0006082_CNS_inflammation1.21656539
58MP0002638_abnormal_pupillary_reflex1.19313478
59MP0005647_abnormal_sex_gland1.14362607
60MP0002106_abnormal_muscle_physiology1.13240673
61MP0000747_muscle_weakness1.12981198
62MP0002295_abnormal_pulmonary_circulatio1.10809404
63MP0006036_abnormal_mitochondrial_physio1.09557672
64MP0010368_abnormal_lymphatic_system1.09477207
65MP0003448_altered_tumor_morphology1.06520732
66MP0002419_abnormal_innate_immunity1.06264231
67* MP0002078_abnormal_glucose_homeostasis1.05941286
68MP0001533_abnormal_skeleton_physiology1.05732441
69MP0005448_abnormal_energy_balance1.05156699
70MP0005503_abnormal_tendon_morphology1.04167629
71MP0001835_abnormal_antigen_presentation1.03978629
72* MP0000759_abnormal_skeletal_muscle1.03292502
73MP0002876_abnormal_thyroid_physiology0.99801244
74MP0002998_abnormal_bone_remodeling0.99173008
75MP0000609_abnormal_liver_physiology0.98705327
76MP0009785_altered_susceptibility_to0.95526625
77MP0001727_abnormal_embryo_implantation0.94450390
78MP0005397_hematopoietic_system_phenotyp0.93886172
79MP0001545_abnormal_hematopoietic_system0.93886172
80MP0000767_abnormal_smooth_muscle0.93320979
81MP0001958_emphysema0.92543154
82MP0002909_abnormal_adrenal_gland0.92468928
83MP0009278_abnormal_bone_marrow0.92468313
84MP0003279_aneurysm0.91979123
85MP0001881_abnormal_mammary_gland0.91467635
86MP0002108_abnormal_muscle_morphology0.91093824
87* MP0000249_abnormal_blood_vessel0.90124041
88MP0005369_muscle_phenotype0.89822689
89MP0005164_abnormal_response_to0.87715149
90MP0002127_abnormal_cardiovascular_syste0.85920432
91MP0003045_fibrosis0.85164991
92MP0003868_abnormal_feces_composition0.84561787
93MP0008961_abnormal_basal_metabolism0.82903097
94MP0005319_abnormal_enzyme/_coenzyme0.82815314
95MP0004085_abnormal_heartbeat0.81496267
96MP0002933_joint_inflammation0.81218126
97MP0002166_altered_tumor_susceptibility0.81204270
98MP0005167_abnormal_blood-brain_barrier0.80566571
99MP0005452_abnormal_adipose_tissue0.80468533
100MP0002269_muscular_atrophy0.78770489
101MP0001879_abnormal_lymphatic_vessel0.78493439
102MP0002139_abnormal_hepatobiliary_system0.78462063
103MP0002006_tumorigenesis0.77050660
104MP0003172_abnormal_lysosome_physiology0.76701039
105MP0009840_abnormal_foam_cell0.75797141
106MP0009643_abnormal_urine_homeostasis0.75322900
107MP0003195_calcinosis0.75262727
108MP0001853_heart_inflammation0.74981859
109MP0001756_abnormal_urination0.74947344
110MP0000230_abnormal_systemic_arterial0.74819535
111MP0005000_abnormal_immune_tolerance0.74336659
112MP0005584_abnormal_enzyme/coenzyme_acti0.74153219
113MP0002090_abnormal_vision0.73427981
114MP0003091_abnormal_cell_migration0.72683793
115MP0003075_altered_response_to0.71708110
116MP0005025_abnormal_response_to0.70820212
117MP0005076_abnormal_cell_differentiation0.70238681
118MP0003300_gastrointestinal_ulcer0.69886884
119MP0000604_amyloidosis0.69468950
120MP0008469_abnormal_protein_level0.69340394
121MP0005165_increased_susceptibility_to0.68587213
122MP0004782_abnormal_surfactant_physiolog0.68464456
123MP0005365_abnormal_bile_salt0.68094294
124MP0002148_abnormal_hypersensitivity_rea0.68018569
125MP0002060_abnormal_skin_morphology0.67441989
126MP0002896_abnormal_bone_mineralization0.64836968
127* MP0003948_abnormal_gas_homeostasis0.62257977
128MP0001984_abnormal_olfaction0.61658678

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)4.90059838
2Myoglobinuria (HP:0002913)4.36748348
3Abnormality of glycolipid metabolism (HP:0010969)3.99420764
4Abnormality of liposaccharide metabolism (HP:0010968)3.99420764
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.99420764
6Acanthosis nigricans (HP:0000956)3.82154483
7Increased connective tissue (HP:0009025)3.81877974
8Hypertriglyceridemia (HP:0002155)3.74541484
9Sudden death (HP:0001699)3.68465598
10Hypoglycemic coma (HP:0001325)3.59294814
11Lipoatrophy (HP:0100578)3.58679821
12Muscle fiber splitting (HP:0003555)3.53969446
13Difficulty running (HP:0009046)3.51907956
14Ketoacidosis (HP:0001993)3.51415512
15Exercise-induced muscle cramps (HP:0003710)3.50080204
16Ventricular tachycardia (HP:0004756)3.41486374
17Insulin-resistant diabetes mellitus (HP:0000831)3.40538810
18Hyperglycinuria (HP:0003108)3.39499060
19Increased cerebral lipofuscin (HP:0011813)3.35724024
20Rhabdomyolysis (HP:0003201)3.33458611
21Abnormality of fatty-acid metabolism (HP:0004359)3.33088092
22Atrioventricular block (HP:0001678)3.31030850
23Bone cyst (HP:0012062)3.21193534
24Axonal loss (HP:0003447)3.19288156
25Asymmetric septal hypertrophy (HP:0001670)3.16676749
26Abnormal atrioventricular conduction (HP:0005150)3.03152347
27Heart block (HP:0012722)3.03035002
28Hyporeflexia of lower limbs (HP:0002600)2.99576532
29Exercise-induced myalgia (HP:0003738)2.92334008
30Reduced subcutaneous adipose tissue (HP:0003758)2.89962002
31Right ventricular cardiomyopathy (HP:0011663)2.89736752
32Vacuolated lymphocytes (HP:0001922)2.88604091
33Hypoalphalipoproteinemia (HP:0003233)2.87113295
34Atrial fibrillation (HP:0005110)2.86940309
35Ketosis (HP:0001946)2.86821056
36Increased muscle lipid content (HP:0009058)2.82810687
37Type 1 muscle fiber predominance (HP:0003803)2.80215920
38Calf muscle hypertrophy (HP:0008981)2.79969857
39Increased serum pyruvate (HP:0003542)2.79677992
40Neck muscle weakness (HP:0000467)2.79601377
41Ankle contracture (HP:0006466)2.79288109
42Frequent falls (HP:0002359)2.79028007
43Distal lower limb muscle weakness (HP:0009053)2.77942346
44Recurrent gram-negative bacterial infections (HP:0005420)2.77231776
45Esophageal varix (HP:0002040)2.76276423
46Abnormality of glycine metabolism (HP:0010895)2.75460360
47Abnormality of serine family amino acid metabolism (HP:0010894)2.75460360
48Palpitations (HP:0001962)2.72548530
49Complement deficiency (HP:0004431)2.71876902
50Systemic lupus erythematosus (HP:0002725)2.69244077
51Increased variability in muscle fiber diameter (HP:0003557)2.67963604
52Eczematoid dermatitis (HP:0000976)2.67028418
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.65497050
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.65254742
55Dicarboxylic aciduria (HP:0003215)2.65254742
56Abnormality of the periventricular white matter (HP:0002518)2.63045374
57Primary atrial arrhythmia (HP:0001692)2.60984883
58Neoplasm of head and neck (HP:0012288)2.59373399
59Esophageal neoplasm (HP:0100751)2.59373399
60Recurrent abscess formation (HP:0002722)2.54461933
61Dilated cardiomyopathy (HP:0001644)2.53139599
62Generalized aminoaciduria (HP:0002909)2.50410783
63Conjunctival hamartoma (HP:0100780)2.50095483
64Polycythemia (HP:0001901)2.49574873
65Muscle hypertrophy of the lower extremities (HP:0008968)2.46526161
66Supraventricular arrhythmia (HP:0005115)2.46478170
67Protrusio acetabuli (HP:0003179)2.45877002
68Supraventricular tachycardia (HP:0004755)2.43395098
69Abnormality of glycolysis (HP:0004366)2.43071796
70Cerebral aneurysm (HP:0004944)2.40469166
71Abnormality of skeletal muscle fiber size (HP:0012084)2.40048597
72* Nausea (HP:0002018)2.39992026
73Facial diplegia (HP:0001349)2.39390751
74Vertebral compression fractures (HP:0002953)2.39343219
75Hydroxyprolinuria (HP:0003080)2.39035318
76Abnormality of proline metabolism (HP:0010907)2.39035318
77Abnormality of the foot musculature (HP:0001436)2.37401672
78Nuclear cataract (HP:0100018)2.36078400
79Tetraparesis (HP:0002273)2.35284890
80Toxemia of pregnancy (HP:0100603)2.34593460
81Neurofibrillary tangles (HP:0002185)2.34045052
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33106169
83Abnormality of macrophages (HP:0004311)2.30587240
84Foot dorsiflexor weakness (HP:0009027)2.30020211
85Spinal rigidity (HP:0003306)2.28608499
86Mutism (HP:0002300)2.27756859
87Multiple enchondromatosis (HP:0005701)2.26830450
88Ragged-red muscle fibers (HP:0003200)2.25967745
89Hypercortisolism (HP:0001578)2.25526546
90* Myocardial infarction (HP:0001658)2.25350322
91Hepatic necrosis (HP:0002605)2.25131781
92Abnormal eating behavior (HP:0100738)2.24653431
93Pulmonary artery stenosis (HP:0004415)2.23782572
94Bundle branch block (HP:0011710)2.22999516
95Insulin resistance (HP:0000855)2.22589389
96Broad metatarsal (HP:0001783)2.22406734
97Cerebral inclusion bodies (HP:0100314)2.21986192
98Abnormality of the left ventricular outflow tract (HP:0011103)2.21611319
99Subaortic stenosis (HP:0001682)2.21611319
100Disinhibition (HP:0000734)2.20320574
101Autoimmune thrombocytopenia (HP:0001973)2.20094662
102Action tremor (HP:0002345)2.18989300
103Amyloidosis (HP:0011034)2.17831195
104Abnormality of the calf musculature (HP:0001430)2.16829860
105Hyperglycemia (HP:0003074)2.16559953
106Dysostosis multiplex (HP:0000943)2.16293132
107Neoplasm of the adrenal gland (HP:0100631)2.15883772
108Rimmed vacuoles (HP:0003805)2.13842684
109Abnormality of complement system (HP:0005339)2.12119969
110Centrally nucleated skeletal muscle fibers (HP:0003687)2.12013800
111EMG: myopathic abnormalities (HP:0003458)2.11055776
112Back pain (HP:0003418)2.10938787
113Hyperammonemia (HP:0001987)2.10160477
114Syncope (HP:0001279)2.08815043
115Scapular winging (HP:0003691)2.08727922
116Decreased subcutaneous fat (HP:0001002)2.08335357
117Steppage gait (HP:0003376)2.07888897
118Bulbar palsy (HP:0001283)2.07556149
119Polyphagia (HP:0002591)2.07002726
120Follicular hyperkeratosis (HP:0007502)2.06364441
121Growth hormone excess (HP:0000845)2.05534090
122Recurrent bacterial skin infections (HP:0005406)2.03257371
123Hemorrhage of the eye (HP:0011885)2.02347017
124Muscle stiffness (HP:0003552)2.01438067
125Gowers sign (HP:0003391)2.00781644
126Abnormality of alanine metabolism (HP:0010916)1.98814532
127Pigmentary retinal degeneration (HP:0001146)1.98285758
128Slender build (HP:0001533)1.97071086
129Vascular tortuosity (HP:0004948)1.97020155
130Myotonia (HP:0002486)1.94687990
131Testicular atrophy (HP:0000029)1.93410984
132Prolonged QT interval (HP:0001657)1.90918153
133Hematochezia (HP:0002573)1.90650363
134Ventricular arrhythmia (HP:0004308)1.88194869
135Subcapsular cataract (HP:0000523)1.87628613
136Gingivitis (HP:0000230)1.87179927
137Mucopolysacchariduria (HP:0008155)1.86863658
138Urinary glycosaminoglycan excretion (HP:0003541)1.86863658
139Hyperalaninemia (HP:0003348)1.85898523
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85898523
141Distal lower limb amyotrophy (HP:0008944)1.85745884
142Abnormality of polysaccharide metabolism (HP:0011012)1.84216770
143Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84216770
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84216770
145Aortic aneurysm (HP:0004942)1.82381338
146* Skin nodule (HP:0200036)1.82007360
147Arterial tortuosity (HP:0005116)1.80017578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.59292340
2CAMK1D3.69984985
3TTN3.35883515
4BCKDK3.31742580
5PDK42.91737433
6PDK32.91737433
7ERN12.58308517
8CAMK1G2.55824985
9PKN22.52689251
10LMTK22.37370857
11SIK12.37363297
12RIPK12.19891765
13PDK22.03994778
14DDR22.01446239
15NEK91.79047241
16RIPK41.78553770
17CAMK11.71214723
18PHKG21.70677966
19PHKG11.70677966
20MOS1.67571580
21TESK11.65953374
22IRAK31.63088784
23LATS21.61344249
24MAPK41.60381035
25PBK1.57073261
26TGFBR21.56715745
27INSRR1.53213651
28NME21.51863849
29MYLK1.49598241
30JAK11.48221781
31DMPK1.46449398
32TBK11.38452155
33OBSCN1.32516872
34PDGFRA1.30506176
35MAP3K61.30332200
36ARAF1.28159028
37MST1R1.25413051
38PRKAA21.25244084
39FGFR31.24871610
40PIK3CA1.23095064
41TYK21.17229552
42TIE11.14922242
43KIT1.13574195
44CDC42BPA1.12046782
45DAPK31.03721699
46JAK21.01863640
47CDK91.01368436
48ABL20.98142516
49GRK50.97708437
50MAPK70.94402869
51MAP3K140.94351102
52PDPK10.92051391
53LIMK10.91447872
54GRK70.89404665
55JAK30.85536244
56FLT30.85089877
57KDR0.84689347
58TRPM70.80625074
59MAP2K30.80244427
60EPHB20.80165330
61PKN10.79883842
62PRKD10.77623475
63MAP2K10.77137927
64CDK60.75961177
65IRAK40.75602129
66PRPF4B0.74936445
67PDGFRB0.73952841
68MAPKAPK30.73159368
69PDK10.72937814
70PRKG10.72757084
71ROCK20.72016407
72CSK0.72011113
73FGFR40.70634082
74MARK10.70370299
75WNK40.70343515
76CAMKK20.69550287
77FRK0.69202311
78PRKAA10.68695540
79PINK10.68418065
80ROCK10.68135339
81PRKCH0.67152214
82BMX0.67078380
83SGK20.66665337
84FER0.66644120
85TYRO30.65194196
86PAK40.63419109
87CAMK2G0.62571258
88NLK0.62344204
89EEF2K0.61968268
90MAP3K50.61344195
91FES0.60785580
92TAOK30.60668563
93ILK0.59470610
94SGK30.58725014
95CAMK2B0.57568699
96STK40.56519454
97IGF1R0.55405517
98MAP3K110.55229659
99IRAK10.54744164
100ADRBK20.53480367
101EPHB10.53361119
102RPS6KL10.53234065
103RPS6KC10.53234065
104MAP3K30.52892155
105PRKACG0.51916159
106CAMK40.51470845
107KSR20.51266279
108MTOR0.49308205
109CSF1R0.48761029
110STK240.48214994
111MAP3K130.47955531
112MAPK120.47800919
113PAK20.47345106
114CAMK2A0.47179768
115ABL10.47045461
116PRKACB0.47012650
117SGK2230.46559283
118SGK4940.46559283
119PTK2B0.45480044
120RET0.44695807
121PTK60.44582845
122HCK0.44383799
123BLK0.43804635
124MAP3K10.42644423
125TEC0.42438522
126RPS6KA20.42315799
127IKBKB0.41639626
128IKBKE0.40215271
129PRKCE0.40058733
130GSK3A0.39404789
131IRAK20.37204358
132DAPK20.35244064
133EPHA30.35111902
134INSR0.35049845
135MAPK110.34934470
136MARK30.34471684
137ZAP700.32374883
138STK30.31098045
139NEK10.29407621
140PRKD30.28957050
141SRC0.28656658
142EGFR0.28646689
143CAMK2D0.28442300
144LATS10.27724653

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.50921357
2Propanoate metabolism_Homo sapiens_hsa006404.03044260
3* PPAR signaling pathway_Homo sapiens_hsa033203.32894303
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.27490307
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.07887851
6Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.97005095
7Fatty acid degradation_Homo sapiens_hsa000712.92787937
8Fatty acid metabolism_Homo sapiens_hsa012122.89160056
9Fatty acid biosynthesis_Homo sapiens_hsa000612.82295182
10Adipocytokine signaling pathway_Homo sapiens_hsa049202.05937572
11Staphylococcus aureus infection_Homo sapiens_hsa051501.91190895
12Carbon metabolism_Homo sapiens_hsa012001.90045893
13Pyruvate metabolism_Homo sapiens_hsa006201.59474556
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56575538
15Lysosome_Homo sapiens_hsa041421.54813372
16beta-Alanine metabolism_Homo sapiens_hsa004101.51611038
17* Glycerolipid metabolism_Homo sapiens_hsa005611.48449816
18Caffeine metabolism_Homo sapiens_hsa002321.47884280
19AMPK signaling pathway_Homo sapiens_hsa041521.46800731
20Insulin resistance_Homo sapiens_hsa049311.41055225
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38671231
22Peroxisome_Homo sapiens_hsa041461.24782456
23Dilated cardiomyopathy_Homo sapiens_hsa054141.20783748
24Histidine metabolism_Homo sapiens_hsa003401.17644336
25Viral myocarditis_Homo sapiens_hsa054161.15064924
26Osteoclast differentiation_Homo sapiens_hsa043801.10647439
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10476878
28Fat digestion and absorption_Homo sapiens_hsa049751.08612647
29Oxidative phosphorylation_Homo sapiens_hsa001901.06642304
30Butanoate metabolism_Homo sapiens_hsa006501.05919251
31Leishmaniasis_Homo sapiens_hsa051401.05473703
32Type II diabetes mellitus_Homo sapiens_hsa049301.01668922
33Insulin signaling pathway_Homo sapiens_hsa049101.00149206
34Ovarian steroidogenesis_Homo sapiens_hsa049130.98351001
35Tuberculosis_Homo sapiens_hsa051520.97191295
36Glycosaminoglycan degradation_Homo sapiens_hsa005310.96941611
37Cardiac muscle contraction_Homo sapiens_hsa042600.96918101
38Phagosome_Homo sapiens_hsa041450.94416370
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91616228
40Legionellosis_Homo sapiens_hsa051340.90889479
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90882273
42Parkinsons disease_Homo sapiens_hsa050120.88847109
43Fatty acid elongation_Homo sapiens_hsa000620.83449894
44Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81531825
45Malaria_Homo sapiens_hsa051440.81281689
46Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79971472
47Phenylalanine metabolism_Homo sapiens_hsa003600.77455940
48HIF-1 signaling pathway_Homo sapiens_hsa040660.77326014
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.77321059
50Starch and sucrose metabolism_Homo sapiens_hsa005000.73963710
51Pertussis_Homo sapiens_hsa051330.73421913
52Amoebiasis_Homo sapiens_hsa051460.73403085
53Alzheimers disease_Homo sapiens_hsa050100.72426146
54Morphine addiction_Homo sapiens_hsa050320.72004804
55ECM-receptor interaction_Homo sapiens_hsa045120.71026636
56Toxoplasmosis_Homo sapiens_hsa051450.71023022
57Sulfur metabolism_Homo sapiens_hsa009200.68474102
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.68437494
59Renin-angiotensin system_Homo sapiens_hsa046140.67231637
60Rheumatoid arthritis_Homo sapiens_hsa053230.66843073
61Sulfur relay system_Homo sapiens_hsa041220.66639124
62Glucagon signaling pathway_Homo sapiens_hsa049220.66565580
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.66409091
64Focal adhesion_Homo sapiens_hsa045100.66280237
65Other glycan degradation_Homo sapiens_hsa005110.65954104
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65513385
67Tryptophan metabolism_Homo sapiens_hsa003800.62225214
68Prion diseases_Homo sapiens_hsa050200.61124356
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60058933
70Steroid biosynthesis_Homo sapiens_hsa001000.56258042
71Renin secretion_Homo sapiens_hsa049240.56122700
72Complement and coagulation cascades_Homo sapiens_hsa046100.55294265
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51682820
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.50006635
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48004548
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46737861
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46384315
78cAMP signaling pathway_Homo sapiens_hsa040240.46299691
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45893197
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45739574
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45631441
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45469356
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44861554
84Lysine degradation_Homo sapiens_hsa003100.44622383
85Glutathione metabolism_Homo sapiens_hsa004800.43841343
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43335383
87Salmonella infection_Homo sapiens_hsa051320.43284503
88Acute myeloid leukemia_Homo sapiens_hsa052210.43078819
89Proteoglycans in cancer_Homo sapiens_hsa052050.41933995
90Nitrogen metabolism_Homo sapiens_hsa009100.41918971
91Folate biosynthesis_Homo sapiens_hsa007900.40662270
92Circadian rhythm_Homo sapiens_hsa047100.40637020
93GABAergic synapse_Homo sapiens_hsa047270.39704266
94Pentose phosphate pathway_Homo sapiens_hsa000300.39050087
95Huntingtons disease_Homo sapiens_hsa050160.38582151
96mTOR signaling pathway_Homo sapiens_hsa041500.37479291
97GnRH signaling pathway_Homo sapiens_hsa049120.37430253
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.37199683
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35584887
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.35452460
101Galactose metabolism_Homo sapiens_hsa000520.35194685
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.34798075
103Protein digestion and absorption_Homo sapiens_hsa049740.34132407
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.33947149
105Gap junction_Homo sapiens_hsa045400.33829281
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.33718678
107Circadian entrainment_Homo sapiens_hsa047130.33336840
108B cell receptor signaling pathway_Homo sapiens_hsa046620.33225327
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32803730
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32774324
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32698937
112Tyrosine metabolism_Homo sapiens_hsa003500.31927614
113Bile secretion_Homo sapiens_hsa049760.31812771
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31298256
115Oxytocin signaling pathway_Homo sapiens_hsa049210.31254413
116Fructose and mannose metabolism_Homo sapiens_hsa000510.30968909
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30775354
118Melanoma_Homo sapiens_hsa052180.30669141
119Collecting duct acid secretion_Homo sapiens_hsa049660.30586225
120TNF signaling pathway_Homo sapiens_hsa046680.30123684
121Platelet activation_Homo sapiens_hsa046110.30019451
122Adherens junction_Homo sapiens_hsa045200.29779570
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29612386
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28909927
125Arginine and proline metabolism_Homo sapiens_hsa003300.28587174
126Estrogen signaling pathway_Homo sapiens_hsa049150.28444563
127Chronic myeloid leukemia_Homo sapiens_hsa052200.27860554
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27659849
129Measles_Homo sapiens_hsa051620.27021144
130Biosynthesis of amino acids_Homo sapiens_hsa012300.26918561
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26918383
132Influenza A_Homo sapiens_hsa051640.26312432
133Apoptosis_Homo sapiens_hsa042100.24834751
134Long-term potentiation_Homo sapiens_hsa047200.23990996
135Hepatitis C_Homo sapiens_hsa051600.23305712
136Arginine biosynthesis_Homo sapiens_hsa002200.23140402
137Gastric acid secretion_Homo sapiens_hsa049710.22824883
138Renal cell carcinoma_Homo sapiens_hsa052110.22749336

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