LPO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of dendritic cell antigen processing and presentation (GO:0002604)9.18253296
2* detection of chemical stimulus involved in sensory perception of taste (GO:0050912)8.74620360
3* detection of chemical stimulus involved in sensory perception (GO:0050907)7.61530738
4positive regulation of Cdc42 GTPase activity (GO:0043089)7.30134050
5regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)7.21993955
6negative regulation of T cell apoptotic process (GO:0070233)6.65048485
7positive regulation of antigen processing and presentation (GO:0002579)6.45117070
8regulation of T-helper 1 cell differentiation (GO:0045625)6.10429344
9positive regulation of granulocyte chemotaxis (GO:0071624)5.74309716
10imidazole-containing compound metabolic process (GO:0052803)5.69291002
11bundle of His cell to Purkinje myocyte communication (GO:0086069)5.62200696
12positive regulation of glycoprotein biosynthetic process (GO:0010560)5.54845952
13retina homeostasis (GO:0001895)5.38783531
14behavioral response to nicotine (GO:0035095)5.33746967
15positive regulation of glycoprotein metabolic process (GO:1903020)5.26922461
16regulation of antigen processing and presentation (GO:0002577)5.26493959
17negative regulation of leukocyte apoptotic process (GO:2000107)5.24306439
18mitochondrial calcium ion transport (GO:0006851)5.19275268
19negative regulation of lymphocyte apoptotic process (GO:0070229)5.12946956
20mitochondrion distribution (GO:0048311)5.01979880
21regulation of Cdc42 GTPase activity (GO:0043088)4.80640589
22positive regulation of receptor biosynthetic process (GO:0010870)4.69523457
23positive regulation of T-helper 1 type immune response (GO:0002827)4.57069261
24NIK/NF-kappaB signaling (GO:0038061)4.46207831
25positive regulation of neutrophil chemotaxis (GO:0090023)4.38191821
26positive regulation of neutrophil migration (GO:1902624)4.38191821
27indole-containing compound catabolic process (GO:0042436)4.30118138
28indolalkylamine catabolic process (GO:0046218)4.30118138
29tryptophan catabolic process (GO:0006569)4.30118138
30regulation of lipoprotein particle clearance (GO:0010984)4.28577622
31indolalkylamine metabolic process (GO:0006586)4.22370852
32neurotransmitter catabolic process (GO:0042135)4.21241578
33positive regulation of growth hormone secretion (GO:0060124)4.20300002
34antigen processing and presentation of endogenous antigen (GO:0019883)4.19126748
35oxygen transport (GO:0015671)4.15970983
36positive regulation of T-helper cell differentiation (GO:0045624)4.13662507
37dendritic cell differentiation (GO:0097028)4.01901594
38valine metabolic process (GO:0006573)4.00277523
39biotin metabolic process (GO:0006768)3.96429524
40kynurenine metabolic process (GO:0070189)3.94632887
41COPI coating of Golgi vesicle (GO:0048205)3.93768042
42Golgi transport vesicle coating (GO:0048200)3.93768042
43negative regulation of interleukin-10 production (GO:0032693)3.90787259
44response to prostaglandin E (GO:0034695)3.85544423
45regulation of T cell apoptotic process (GO:0070232)3.84033983
46response to nitric oxide (GO:0071731)3.83533320
47dendritic cell chemotaxis (GO:0002407)3.82646455
48growth hormone secretion (GO:0030252)3.78911277
49tryptophan metabolic process (GO:0006568)3.78875554
50myeloid dendritic cell differentiation (GO:0043011)3.77176888
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.75467076
52hemidesmosome assembly (GO:0031581)3.69784486
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63671406
54response to pheromone (GO:0019236)3.59896450
55peptide catabolic process (GO:0043171)3.58846609
56cellular ketone body metabolic process (GO:0046950)3.54232005
57cellular response to ATP (GO:0071318)3.47944453
58gas transport (GO:0015669)3.47520982
59positive regulation of interleukin-1 beta secretion (GO:0050718)3.47066291
60tongue development (GO:0043586)3.45432635
61UDP-N-acetylglucosamine metabolic process (GO:0006047)3.45176118
62positive regulation of interleukin-1 secretion (GO:0050716)3.38131068
63regulation of female receptivity (GO:0045924)3.35686473
64piRNA metabolic process (GO:0034587)3.35158039
65detection of light stimulus involved in sensory perception (GO:0050962)3.32115272
66detection of light stimulus involved in visual perception (GO:0050908)3.32115272
67regulation of cellular extravasation (GO:0002691)3.32070921
68regulation of granulocyte chemotaxis (GO:0071622)3.31278665
69maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.31112337
70positive regulation of prostaglandin secretion (GO:0032308)3.29354258
71DNA deamination (GO:0045006)3.28271179
72L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.26608911
73signal peptide processing (GO:0006465)3.24901902
74pericardium development (GO:0060039)3.23295928
75positive regulation of natural killer cell differentiation (GO:0032825)3.21480892
76indole-containing compound metabolic process (GO:0042430)3.20919643
77meiotic chromosome segregation (GO:0045132)3.20816000
78rRNA catabolic process (GO:0016075)3.18004754
79ketone body metabolic process (GO:1902224)3.17390947
80regulation of T-helper 1 type immune response (GO:0002825)3.16134168
81axoneme assembly (GO:0035082)3.08205838
82organic cation transport (GO:0015695)3.08041958
83substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.06665283
84substrate-independent telencephalic tangential migration (GO:0021826)3.06665283
85regulation of neutrophil chemotaxis (GO:0090022)3.04779092
86regulation of neutrophil migration (GO:1902622)3.04779092
87regulation of natural killer cell differentiation (GO:0032823)3.04746454
88regulation of interleukin-1 beta secretion (GO:0050706)3.04575010
89embryonic heart tube development (GO:0035050)3.04211072
90negative regulation of telomere maintenance (GO:0032205)3.03149074
91myeloid dendritic cell activation (GO:0001773)3.02864548
92branched-chain amino acid metabolic process (GO:0009081)3.02576842
93regulation of interleukin-1 secretion (GO:0050704)3.01321990
94negative regulation of mast cell activation (GO:0033004)3.00028036
95DNA methylation involved in gamete generation (GO:0043046)2.98946921
96regulation of prostaglandin secretion (GO:0032306)2.98504330
97response to prostaglandin (GO:0034694)2.97319584
98protein localization to cilium (GO:0061512)2.96853822
99nitric oxide biosynthetic process (GO:0006809)2.96747725
100amino acid salvage (GO:0043102)2.96737427
101L-methionine salvage (GO:0071267)2.96737427
102L-methionine biosynthetic process (GO:0071265)2.96737427
103amine catabolic process (GO:0009310)2.96267716
104cellular biogenic amine catabolic process (GO:0042402)2.96267716
105galactose metabolic process (GO:0006012)2.95766383
106epithelial cilium movement (GO:0003351)2.95315586
107primary amino compound metabolic process (GO:1901160)2.94907193
108water-soluble vitamin biosynthetic process (GO:0042364)2.92631646
109renal absorption (GO:0070293)2.90955585
110regulation of leukocyte apoptotic process (GO:2000106)2.90121345
111positive regulation of NF-kappaB import into nucleus (GO:0042346)2.89626690
112preassembly of GPI anchor in ER membrane (GO:0016254)2.88547720
113NAD biosynthetic process (GO:0009435)2.88238933
114branched-chain amino acid catabolic process (GO:0009083)2.87888915
115cilium or flagellum-dependent cell motility (GO:0001539)2.87040490
116protein retention in ER lumen (GO:0006621)2.86581999
117neuronal action potential (GO:0019228)2.86295272
118reflex (GO:0060004)2.85457689
119exogenous drug catabolic process (GO:0042738)2.85352767
120dopamine transport (GO:0015872)2.85253469
121regulation of T-helper cell differentiation (GO:0045622)2.82277714
122platelet dense granule organization (GO:0060155)2.82194159
123regulation of rhodopsin mediated signaling pathway (GO:0022400)2.81768865
124protein complex biogenesis (GO:0070271)2.80819798
125positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.78928752
126multicellular organism reproduction (GO:0032504)2.78737566
127gamma-aminobutyric acid transport (GO:0015812)2.78159123
128rhodopsin mediated signaling pathway (GO:0016056)2.78149168
129female mating behavior (GO:0060180)2.77962860
130S-adenosylmethionine metabolic process (GO:0046500)2.76955942
131positive regulation of interleukin-1 beta production (GO:0032731)2.76447749
132ubiquinone biosynthetic process (GO:0006744)2.75797611
133regulation of nuclear cell cycle DNA replication (GO:0033262)2.75394519
134positive regulation of interleukin-1 production (GO:0032732)2.74271009
135regulation of growth hormone secretion (GO:0060123)2.74208715
136cellular copper ion homeostasis (GO:0006878)2.73499025
137protein polyglutamylation (GO:0018095)2.72674225
138asymmetric protein localization (GO:0008105)2.72577089
139positive regulation of macrophage cytokine production (GO:0060907)2.72353884
140mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72242557
141mitochondrial respiratory chain complex I assembly (GO:0032981)2.72242557
142NADH dehydrogenase complex assembly (GO:0010257)2.72242557
143L-fucose catabolic process (GO:0042355)2.67773609
144fucose catabolic process (GO:0019317)2.67773609
145L-fucose metabolic process (GO:0042354)2.67773609
146respiratory chain complex IV assembly (GO:0008535)2.67011970
147behavioral response to ethanol (GO:0048149)2.66321072
148auditory receptor cell stereocilium organization (GO:0060088)2.65913840
149dendritic cell migration (GO:0036336)2.65325408
150serotonin metabolic process (GO:0042428)2.65170222
151regulation of hexokinase activity (GO:1903299)2.65007325
152regulation of glucokinase activity (GO:0033131)2.65007325
153phosphatidylinositol acyl-chain remodeling (GO:0036149)2.64570911
154positive regulation of monocyte chemotaxis (GO:0090026)2.63275976
155negative regulation of cytosolic calcium ion concentration (GO:0051481)2.63230286
156positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.63164084
157drug catabolic process (GO:0042737)2.63002715
158photoreceptor cell maintenance (GO:0045494)2.62888431
159pharyngeal system development (GO:0060037)2.61939246
160epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61678981
161regulation of lymphocyte apoptotic process (GO:0070228)2.61552675
162regulation of cilium movement (GO:0003352)2.60830158
163neural tube formation (GO:0001841)2.60750282
164regulation of memory T cell differentiation (GO:0043380)2.60530926
165neurotransmitter metabolic process (GO:0042133)2.60527070
166mitochondrial respiratory chain complex assembly (GO:0033108)2.58726653
167reciprocal DNA recombination (GO:0035825)2.58700715
168reciprocal meiotic recombination (GO:0007131)2.58700715
169regulation of receptor biosynthetic process (GO:0010869)2.58055545
170sulfation (GO:0051923)2.57320298
171negative regulation of transcription regulatory region DNA binding (GO:2000678)2.56617669
172positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.55674557
173vitamin transmembrane transport (GO:0035461)2.55509637
174positive regulation of fatty acid transport (GO:2000193)2.53944452
175positive regulation of interleukin-12 production (GO:0032735)2.53701657
176nephron tubule morphogenesis (GO:0072078)2.53425552
177nephron epithelium morphogenesis (GO:0072088)2.53425552
178transcytosis (GO:0045056)2.52844217
179protein-cofactor linkage (GO:0018065)2.52360489
180retinal cone cell development (GO:0046549)2.52248525
181startle response (GO:0001964)2.51534312
182tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50882807
183RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50882807
184G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50822860
185mannosylation (GO:0097502)2.49081953
186negative regulation of synaptic transmission, GABAergic (GO:0032229)2.48872017
187methionine biosynthetic process (GO:0009086)2.48768293
188cytochrome complex assembly (GO:0017004)2.48449754
189alanine transport (GO:0032328)2.48416475
190proline transport (GO:0015824)2.48277868
191cAMP catabolic process (GO:0006198)2.47966736
192ubiquinone metabolic process (GO:0006743)2.46981383
193cilium movement (GO:0003341)2.46484931
194nonmotile primary cilium assembly (GO:0035058)2.45176845
195killing of cells of other organism (GO:0031640)2.45016026
196disruption of cells of other organism (GO:0044364)2.45016026
197* detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)15.7850659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.60107023
2ESR1_20079471_ChIP-ChIP_T-47D_Human4.41236154
3ZNF274_21170338_ChIP-Seq_K562_Hela3.81422976
4EZH2_22144423_ChIP-Seq_EOC_Human3.67331832
5* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.45203260
6VDR_22108803_ChIP-Seq_LS180_Human3.16308998
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90636731
8GBX2_23144817_ChIP-Seq_PC3_Human2.82710969
9IGF1R_20145208_ChIP-Seq_DFB_Human2.67245255
10AR_21909140_ChIP-Seq_LNCAP_Human2.63805495
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.60469369
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.59474697
13FOXO3_23340844_ChIP-Seq_DLD1_Human2.57390598
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.52213956
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37712012
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36977715
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.29962011
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27563523
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.26561348
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20171688
21SOX2_27498859_Chip-Seq_STOMACH_Mouse2.15313298
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.13342608
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.07363427
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06382937
25FUS_26573619_Chip-Seq_HEK293_Human2.06112287
26EWS_26573619_Chip-Seq_HEK293_Human2.04402059
27SOX2_20726797_ChIP-Seq_SW620_Human1.97806483
28ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.95383930
29P300_19829295_ChIP-Seq_ESCs_Human1.94931477
30ER_23166858_ChIP-Seq_MCF-7_Human1.93040735
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84821987
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82130617
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80576962
34CBP_20019798_ChIP-Seq_JUKART_Human1.77250548
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.77250548
36TAF15_26573619_Chip-Seq_HEK293_Human1.75749663
37STAT1_17558387_ChIP-Seq_HELA_Human1.73358062
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.70293974
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68456928
40TP53_22573176_ChIP-Seq_HFKS_Human1.67685222
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66018832
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64499216
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64064391
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.63374623
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62420200
46CLOCK_20551151_ChIP-Seq_293T_Human1.61514403
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60961315
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60961315
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.58012342
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57539717
51DROSHA_22980978_ChIP-Seq_HELA_Human1.57034598
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.55148136
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54978731
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54386279
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.54080527
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52688364
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.52281014
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51723394
59NANOG_19829295_ChIP-Seq_ESCs_Human1.50915917
60SOX2_19829295_ChIP-Seq_ESCs_Human1.50915917
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49042967
62STAT3_23295773_ChIP-Seq_U87_Human1.47466353
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.44638739
64GATA4_25053715_ChIP-Seq_YYC3_Human1.41997046
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41868605
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.41868605
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.41863597
68IRF1_19129219_ChIP-ChIP_H3396_Human1.41616519
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.41372951
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40170501
71FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.39833457
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38044853
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.37246360
74AR_25329375_ChIP-Seq_VCAP_Human1.36638368
75SMAD4_21799915_ChIP-Seq_A2780_Human1.36598022
76* TCF4_23295773_ChIP-Seq_U87_Human1.36115966
77KAP1_22055183_ChIP-Seq_ESCs_Mouse1.35674328
78* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34664085
79AR_21572438_ChIP-Seq_LNCaP_Human1.33975726
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33372996
81ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33345969
82GATA1_22025678_ChIP-Seq_K562_Human1.32985223
83* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32912775
84REST_21632747_ChIP-Seq_MESCs_Mouse1.32812537
85AR_20517297_ChIP-Seq_VCAP_Human1.32508716
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31417753
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30123976
88RACK7_27058665_Chip-Seq_MCF-7_Human1.30031978
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.29778439
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28739279
91GATA6_25053715_ChIP-Seq_YYC3_Human1.28555762
92FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28342839
93MYC_18940864_ChIP-ChIP_HL60_Human1.28318172
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28081017
95VDR_24787735_ChIP-Seq_THP-1_Human1.27285729
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.26951985
97SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26883905
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.26619711
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26462067
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26425586
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25586415
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23686470
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23500143
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23358072
105CDX2_22108803_ChIP-Seq_LS180_Human1.23290127
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21475519
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21067210
108TCF4_18268006_ChIP-ChIP_LS174T_Human1.19797188
109RUNX2_22187159_ChIP-Seq_PCA_Human1.19232009
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19038888
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18990794
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17700665
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.17642079
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.16110997
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.15496377
116GABP_17652178_ChIP-ChIP_JURKAT_Human1.15366569
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.14617368
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.14442541
119SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13426354
120BCAT_22108803_ChIP-Seq_LS180_Human1.13359973
121EST1_17652178_ChIP-ChIP_JURKAT_Human1.13290209
122EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13178487
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.12739429
124* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11528092
125JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11516837
126SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10413552
127MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10408759
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09950152
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08729739
130HOXB7_26014856_ChIP-Seq_BT474_Human1.08703744
131RNF2_27304074_Chip-Seq_NSC_Mouse1.08137035
132LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07289987
133DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07029439
134SMAD4_21741376_ChIP-Seq_EPCs_Human1.06448964
135LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05620735
136EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01607631
137RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01607631
138KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01577654
139MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01216678
140AHR_22903824_ChIP-Seq_MCF-7_Human1.00771027
141MYC_19829295_ChIP-Seq_ESCs_Human1.00183995
142* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99860026
143ERA_21632823_ChIP-Seq_H3396_Human0.99846994
144FOXH1_21741376_ChIP-Seq_EPCs_Human0.99306696
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.99108795
146FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99099413
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99068046
148RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99065859
149GATA3_26560356_Chip-Seq_TH2_Human0.98968054
150KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98535164
151SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98488071
152NANOG_20526341_ChIP-Seq_ESCs_Human0.98360645
153* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98086459
154TAF2_19829295_ChIP-Seq_ESCs_Human0.98021081
155HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97834478
156TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97462238
157TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97430560
158AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97321896
159FOXA1_25552417_ChIP-Seq_VCAP_Human0.95441194
160EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94380662
161NCOR_22424771_ChIP-Seq_293T_Human0.93889441
162ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93617231
163TP63_23658742_ChIP-Seq_EP156T_Human0.92323355
164NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91802667
165EGR1_19374776_ChIP-ChIP_THP-1_Human0.89852059
166SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89565793
167SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89087442
168GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87050690
169* CEBPB_22108803_ChIP-Seq_LS180_Human0.86969387
170TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86448756
171SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85802226
172CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85449782
173AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84918185
174TCF4_22108803_ChIP-Seq_LS180_Human0.84241016
175SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83897268
176SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83897268
177ARNT_22903824_ChIP-Seq_MCF-7_Human0.83502505
178NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83296546
179RNF2_27304074_Chip-Seq_ESCs_Mouse0.82861360
180GATA3_24758297_ChIP-Seq_MCF-7_Human0.82708236
181IRF8_27001747_Chip-Seq_BMDM_Mouse0.81591183
182TP53_18474530_ChIP-ChIP_U2OS_Human0.80320105
183KDM2B_26808549_Chip-Seq_REH_Human0.80036601
184ERG_20517297_ChIP-Seq_VCAP_Human0.79902157
185IRF8_22096565_ChIP-ChIP_GC-B_Human0.79681969
186VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.78536956
187NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78222974
188NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78222974
189KLF5_25053715_ChIP-Seq_YYC3_Human0.77719018
190EZH2_27294783_Chip-Seq_ESCs_Mouse0.77543956
191RXR_22108803_ChIP-Seq_LS180_Human0.76907444

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat9.18583556
2MP0001346_abnormal_lacrimal_gland7.20170994
3MP0002876_abnormal_thyroid_physiology5.04714303
4MP0000685_abnormal_immune_system4.31598373
5MP0001348_abnormal_lacrimal_gland4.10518152
6MP0005645_abnormal_hypothalamus_physiol3.61083530
7MP0003136_yellow_coat_color3.46798282
8MP0001873_stomach_inflammation3.36168861
9MP0003195_calcinosis3.29110639
10MP0005310_abnormal_salivary_gland2.91168101
11MP0001881_abnormal_mammary_gland2.85211033
12MP0008877_abnormal_DNA_methylation2.82033655
13MP0001835_abnormal_antigen_presentation2.79543119
14MP0003646_muscle_fatigue2.75878959
15MP0000372_irregular_coat_pigmentation2.74105368
16MP0001968_abnormal_touch/_nociception2.46877082
17MP0010030_abnormal_orbit_morphology2.45079984
18MP0002837_dystrophic_cardiac_calcinosis2.44834612
19MP0000613_abnormal_salivary_gland2.37716055
20MP0005551_abnormal_eye_electrophysiolog2.35920558
21MP0008875_abnormal_xenobiotic_pharmacok2.33248654
22MP0004147_increased_porphyrin_level2.30945585
23MP0004043_abnormal_pH_regulation2.12175614
24MP0004885_abnormal_endolymph2.06458499
25MP0002102_abnormal_ear_morphology2.01916636
26MP0004510_myositis1.99710942
27MP0006276_abnormal_autonomic_nervous1.99397627
28MP0001986_abnormal_taste_sensitivity1.97407556
29MP0006292_abnormal_olfactory_placode1.95166691
30MP0002277_abnormal_respiratory_mucosa1.90051630
31MP0003879_abnormal_hair_cell1.89783466
32MP0000569_abnormal_digit_pigmentation1.85297938
33MP0002736_abnormal_nociception_after1.84511025
34MP0002009_preneoplasia1.84285560
35MP0010234_abnormal_vibrissa_follicle1.83462407
36MP0008872_abnormal_physiological_respon1.78677134
37MP0006072_abnormal_retinal_apoptosis1.78181194
38MP0002877_abnormal_melanocyte_morpholog1.74141269
39MP0003011_delayed_dark_adaptation1.73660185
40MP0000579_abnormal_nail_morphology1.73194914
41MP0002163_abnormal_gland_morphology1.73117474
42MP0006082_CNS_inflammation1.71778555
43MP0009046_muscle_twitch1.70277071
44MP0005253_abnormal_eye_physiology1.68796900
45MP0009745_abnormal_behavioral_response1.68473619
46MP0004142_abnormal_muscle_tone1.68396826
47MP0003787_abnormal_imprinting1.55577233
48MP0000470_abnormal_stomach_morphology1.51211330
49MP0004264_abnormal_extraembryonic_tissu1.50238063
50MP0009764_decreased_sensitivity_to1.50088479
51MP0002653_abnormal_ependyma_morphology1.49948181
52MP0005410_abnormal_fertilization1.47478189
53MP0005174_abnormal_tail_pigmentation1.45409399
54MP0010352_gastrointestinal_tract_polyps1.39779580
55MP0002272_abnormal_nervous_system1.37230263
56MP0001486_abnormal_startle_reflex1.35080392
57MP0003959_abnormal_lean_body1.32815852
58MP0010155_abnormal_intestine_physiology1.31332936
59MP0000003_abnormal_adipose_tissue1.30033920
60MP0005379_endocrine/exocrine_gland_phen1.27564449
61MP0001663_abnormal_digestive_system1.25500787
62MP0000631_abnormal_neuroendocrine_gland1.25190383
63MP0002572_abnormal_emotion/affect_behav1.24863983
64MP0000427_abnormal_hair_cycle1.23888438
65MP0005647_abnormal_sex_gland1.23310585
66MP0002638_abnormal_pupillary_reflex1.22604896
67MP0005075_abnormal_melanosome_morpholog1.22563009
68MP0005389_reproductive_system_phenotype1.21636814
69MP0004742_abnormal_vestibular_system1.21458115
70MP0002896_abnormal_bone_mineralization1.21232102
71MP0004133_heterotaxia1.21071658
72MP0004782_abnormal_surfactant_physiolog1.20188529
73MP0001529_abnormal_vocalization1.19204860
74MP0002938_white_spotting1.18216645
75MP0002735_abnormal_chemical_nociception1.16634219
76MP0004924_abnormal_behavior1.15321074
77MP0005386_behavior/neurological_phenoty1.15321074
78MP0005220_abnormal_exocrine_pancreas1.14900968
79MP0005167_abnormal_blood-brain_barrier1.14528317
80MP0002557_abnormal_social/conspecific_i1.13329661
81MP0003183_abnormal_peptide_metabolism1.12280377
82MP0005248_abnormal_Harderian_gland1.11938933
83MP0002733_abnormal_thermal_nociception1.11780105
84MP0002796_impaired_skin_barrier1.11362183
85MP0008775_abnormal_heart_ventricle1.11196457
86MP0000538_abnormal_urinary_bladder1.11168666
87MP0002234_abnormal_pharynx_morphology1.08274507
88MP0001970_abnormal_pain_threshold1.07917025
89MP0005381_digestive/alimentary_phenotyp1.07450617
90MP0003880_abnormal_central_pattern1.07250886
91MP0003718_maternal_effect1.07110476
92MP0000230_abnormal_systemic_arterial1.07063901
93MP0001501_abnormal_sleep_pattern1.06131949
94MP0010678_abnormal_skin_adnexa1.05374987
95MP0009780_abnormal_chondrocyte_physiolo1.02467844
96MP0005332_abnormal_amino_acid1.02031167
97MP0003453_abnormal_keratinocyte_physiol1.01972137
98MP0001984_abnormal_olfaction1.01696774
99MP0005084_abnormal_gallbladder_morpholo1.01391593
100MP0003300_gastrointestinal_ulcer1.00543428
101MP0001905_abnormal_dopamine_level0.99837609
102MP0002064_seizures0.99584639
103MP0004130_abnormal_muscle_cell0.99403291
104MP0005187_abnormal_penis_morphology0.98158851
105MP0002067_abnormal_sensory_capabilities0.97401251
106MP0001919_abnormal_reproductive_system0.97379365
107MP0004145_abnormal_muscle_electrophysio0.96050717
108MP0002095_abnormal_skin_pigmentation0.96002563
109MP0002148_abnormal_hypersensitivity_rea0.95825482
110MP0001299_abnormal_eye_distance/0.95685010
111MP0001853_heart_inflammation0.95329495
112MP0008789_abnormal_olfactory_epithelium0.94755814
113MP0002166_altered_tumor_susceptibility0.93718119
114MP0010329_abnormal_lipoprotein_level0.90067040
115MP0009765_abnormal_xenobiotic_induced0.89474187
116MP0003698_abnormal_male_reproductive0.89146032
117MP0002909_abnormal_adrenal_gland0.88982997
118MP0005195_abnormal_posterior_eye0.88748625
119MP0005623_abnormal_meninges_morphology0.88418358
120MP0005671_abnormal_response_to0.87686913
121MP0000383_abnormal_hair_follicle0.87023580
122MP0000858_altered_metastatic_potential0.86425895
123MP0008995_early_reproductive_senescence0.85604388
124MP0006036_abnormal_mitochondrial_physio0.85579575
125MP0000627_abnormal_mammary_gland0.84337645
126MP0001764_abnormal_homeostasis0.83146449
127MP0001666_abnormal_nutrient_absorption0.82613758
128MP0003806_abnormal_nucleotide_metabolis0.82221790
129MP0001849_ear_inflammation0.81631406
130MP0003252_abnormal_bile_duct0.81390114
131MP0009785_altered_susceptibility_to0.81196693
132MP0005197_abnormal_uvea_morphology0.81183434
133MP0003705_abnormal_hypodermis_morpholog0.81141163
134MP0002063_abnormal_learning/memory/cond0.80860700
135MP0002928_abnormal_bile_duct0.80496729
136MP0003635_abnormal_synaptic_transmissio0.79311578
137MP0005387_immune_system_phenotype0.79135836
138MP0001790_abnormal_immune_system0.79135836
139MP0001963_abnormal_hearing_physiology0.79089950
140MP0000026_abnormal_inner_ear0.78996370
141MP0002160_abnormal_reproductive_system0.78315203
142MP0001845_abnormal_inflammatory_respons0.77286489
143MP0009384_cardiac_valve_regurgitation0.76591657
144MP0005377_hearing/vestibular/ear_phenot0.75892892
145MP0003878_abnormal_ear_physiology0.75892892
146MP0002098_abnormal_vibrissa_morphology0.75390810
147MP0009643_abnormal_urine_homeostasis0.75014025
148MP0003283_abnormal_digestive_organ0.74574968
149MP0000647_abnormal_sebaceous_gland0.73947307
150MP0004381_abnormal_hair_follicle0.73894561
151MP0002138_abnormal_hepatobiliary_system0.73576868
152MP0003638_abnormal_response/metabolism_0.72166258
153MP0004272_abnormal_basement_membrane0.68727100
154MP0002971_abnormal_brown_adipose0.67237680
155MP0001533_abnormal_skeleton_physiology0.66211576
156MP0005000_abnormal_immune_tolerance0.65618293
157MP0003868_abnormal_feces_composition0.64050527
158MP0002060_abnormal_skin_morphology0.63842643
159MP0002006_tumorigenesis0.63456618
160MP0005025_abnormal_response_to0.62285208
161MP0001485_abnormal_pinna_reflex0.61477478
162MP0005085_abnormal_gallbladder_physiolo0.61199078
163MP0005646_abnormal_pituitary_gland0.59099444
164MP0010386_abnormal_urinary_bladder0.56784455
165MP0000762_abnormal_tongue_morphology0.53954926
166MP0003075_altered_response_to0.53580309
167MP0000462_abnormal_digestive_system0.52247119
168MP0004019_abnormal_vitamin_homeostasis0.51869434
169MP0005375_adipose_tissue_phenotype0.51525208
170MP0002693_abnormal_pancreas_physiology0.50404698
171MP0001216_abnormal_epidermal_layer0.50043870
172MP0003690_abnormal_glial_cell0.49724459
173MP0003763_abnormal_thymus_physiology0.49482167
174MP0005367_renal/urinary_system_phenotyp0.48051215
175MP0000516_abnormal_urinary_system0.48051215
176MP0002970_abnormal_white_adipose0.47338231
177MP0002405_respiratory_system_inflammati0.46550423
178MP0004947_skin_inflammation0.46400302
179MP0001851_eye_inflammation0.45009013
180MP0000467_abnormal_esophagus_morphology0.44190510
181MP0009115_abnormal_fat_cell0.42488420
182MP0003795_abnormal_bone_structure0.41186395

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.11114614
2Abnormal pupillary function (HP:0007686)5.44922572
3Congenital stationary night blindness (HP:0007642)5.04291928
4Fibular aplasia (HP:0002990)4.96196208
5Hydroxyprolinuria (HP:0003080)4.92441547
6Abnormality of proline metabolism (HP:0010907)4.92441547
7Recurrent cutaneous fungal infections (HP:0011370)4.79730906
8Chronic mucocutaneous candidiasis (HP:0002728)4.79730906
9Milia (HP:0001056)4.34984375
10Pancreatic cysts (HP:0001737)4.29033872
11Onycholysis (HP:0001806)4.28095301
12Aplasia/Hypoplasia of the spleen (HP:0010451)4.18751185
13Keratoconjunctivitis (HP:0001096)4.16787410
14Lip pit (HP:0100267)4.02766174
15True hermaphroditism (HP:0010459)3.97769931
16Hypoplasia of dental enamel (HP:0006297)3.95006023
17Double outlet right ventricle (HP:0001719)3.94763965
18Congenital malformation of the right heart (HP:0011723)3.94763965
19Pancreatic fibrosis (HP:0100732)3.72910514
20Symphalangism affecting the phalanges of the hand (HP:0009773)3.72312708
21Molar tooth sign on MRI (HP:0002419)3.70344373
22Abnormality of midbrain morphology (HP:0002418)3.70344373
23Eczematoid dermatitis (HP:0000976)3.68280716
24Abnormal rod and cone electroretinograms (HP:0008323)3.64100699
25Plantar hyperkeratosis (HP:0007556)3.64070059
26Nephronophthisis (HP:0000090)3.61910972
27Type I diabetes mellitus (HP:0100651)3.59675818
28Abnormality of calcium-phosphate metabolism (HP:0100530)3.57636757
29Atrophic scars (HP:0001075)3.42083531
30Attenuation of retinal blood vessels (HP:0007843)3.41917859
31Type II lissencephaly (HP:0007260)3.26414683
32Abnormality of the gastric mucosa (HP:0004295)3.24198416
33Mesomelia (HP:0003027)3.19430040
34Abolished electroretinogram (ERG) (HP:0000550)3.18698645
35Abnormality of the renal medulla (HP:0100957)3.16757907
36Hyperphosphatemia (HP:0002905)3.16375062
37Abnormality of the renal cortex (HP:0011035)3.16135170
38Asplenia (HP:0001746)3.15111305
39Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.12716112
40Tubular atrophy (HP:0000092)3.08421306
41Fragile skin (HP:0001030)3.07164797
42Xerostomia (HP:0000217)3.05911545
43Decreased central vision (HP:0007663)2.96934776
44Tetraparesis (HP:0002273)2.95250376
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.94753495
46Hypercortisolism (HP:0001578)2.93148928
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.92506148
48Upper limb muscle weakness (HP:0003484)2.88031836
49Hyperventilation (HP:0002883)2.87986884
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.86891632
51Progressive inability to walk (HP:0002505)2.86443997
52Recurrent skin infections (HP:0001581)2.85980632
53Fragile nails (HP:0001808)2.84236200
54Concave nail (HP:0001598)2.82767995
55Abnormality of the phalanges of the 5th finger (HP:0004213)2.82602814
56Bile duct proliferation (HP:0001408)2.79475166
57Abnormal biliary tract physiology (HP:0012439)2.79475166
58Polydipsia (HP:0001959)2.78056834
59Abnormal drinking behavior (HP:0030082)2.78056834
60Recurrent fungal infections (HP:0002841)2.77897864
61Aplasia/Hypoplasia of the fovea (HP:0008060)2.74737937
62Hypoplasia of the fovea (HP:0007750)2.74737937
63Palmoplantar hyperkeratosis (HP:0000972)2.73625541
64Synostosis involving the elbow (HP:0003938)2.72064440
65Humeroradial synostosis (HP:0003041)2.72064440
66Abnormality of the neuromuscular junction (HP:0003398)2.72049982
67Fatigable weakness (HP:0003473)2.72049982
68Medial flaring of the eyebrow (HP:0010747)2.67674560
69Radial bowing (HP:0002986)2.67599410
70Increased IgE level (HP:0003212)2.63542179
71Decreased electroretinogram (ERG) amplitude (HP:0000654)2.62665528
72Cystic liver disease (HP:0006706)2.60510909
73Type 2 muscle fiber atrophy (HP:0003554)2.59883938
74Truncus arteriosus (HP:0001660)2.59129135
75Rectal prolapse (HP:0002035)2.57789432
76Short 1st metacarpal (HP:0010034)2.55663000
77Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.55663000
78Abnormality of the phalanges of the 2nd finger (HP:0009541)2.55315496
79Bony spicule pigmentary retinopathy (HP:0007737)2.51109192
80Enlarged epiphyses (HP:0010580)2.49624009
81Interstitial pulmonary disease (HP:0006530)2.48856059
82Inability to walk (HP:0002540)2.48233300
83Cerebellar dysplasia (HP:0007033)2.46737542
84Pendular nystagmus (HP:0012043)2.46494679
85Amelogenesis imperfecta (HP:0000705)2.46223482
86Absent/shortened dynein arms (HP:0200106)2.45814069
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.45814069
88Sensorimotor neuropathy (HP:0007141)2.45499799
89Palmar hyperkeratosis (HP:0010765)2.45060227
90Deformed tarsal bones (HP:0008119)2.44679845
91Premature loss of primary teeth (HP:0006323)2.43231583
92Cortical dysplasia (HP:0002539)2.41678554
93Abnormality of the 1st metacarpal (HP:0010009)2.39472963
94Renal cortical cysts (HP:0000803)2.38685414
95Tongue fasciculations (HP:0001308)2.35886332
96Increased corneal curvature (HP:0100692)2.35174384
97Keratoconus (HP:0000563)2.35174384
98Ankyloglossia (HP:0010296)2.29324058
993-Methylglutaconic aciduria (HP:0003535)2.25681292
100Cholelithiasis (HP:0001081)2.23845604
101Abnormality of macular pigmentation (HP:0008002)2.23205555
102Hemiparesis (HP:0001269)2.22917935
103Palpitations (HP:0001962)2.22355409
104Pustule (HP:0200039)2.21950167
105Abnormality of the proximal phalanges of the hand (HP:0009834)2.20732383
106Lissencephaly (HP:0001339)2.19702473
107Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19600408
108Abnormality of alanine metabolism (HP:0010916)2.19600408
109Hyperalaninemia (HP:0003348)2.19600408
110Gaze-evoked nystagmus (HP:0000640)2.19491985
111Abnormality of the fovea (HP:0000493)2.19318954
112Hematochezia (HP:0002573)2.19070067
113Muscle fibrillation (HP:0010546)2.16325010
114Chronic hepatic failure (HP:0100626)2.15979692
115Large for gestational age (HP:0001520)2.15518794
116Decreased circulating renin level (HP:0003351)2.15505647
117Abnormality of the intrinsic pathway (HP:0010989)2.15027383
118Muscle fiber atrophy (HP:0100295)2.14747982
119Polyuria (HP:0000103)2.14532841
120Confusion (HP:0001289)2.13966636
121Congenital hepatic fibrosis (HP:0002612)2.12903566
122Congenital, generalized hypertrichosis (HP:0004540)2.12752275
123Back pain (HP:0003418)2.10973665
1242-3 toe syndactyly (HP:0004691)2.10317582
125Nail dystrophy (HP:0008404)2.10254059
126Constricted visual fields (HP:0001133)2.09474266
127Abnormal delayed hypersensitivity skin test (HP:0002963)2.07952619
128Abnormality of the 2nd finger (HP:0004100)2.06907647
129Bilateral microphthalmos (HP:0007633)2.06258827
130Spastic diplegia (HP:0001264)2.05925905
131Abnormal respiratory epithelium morphology (HP:0012253)2.04994012
132Abnormal respiratory motile cilium morphology (HP:0005938)2.04994012
133Sclerocornea (HP:0000647)2.04887772
134Abnormal auditory evoked potentials (HP:0006958)2.03512355
135Periodontitis (HP:0000704)2.02482948
136Furrowed tongue (HP:0000221)2.01320861
137Abnormal gallbladder morphology (HP:0012437)2.00619477
138Anencephaly (HP:0002323)1.99608660
139Male pseudohermaphroditism (HP:0000037)1.99007494
140Nephrogenic diabetes insipidus (HP:0009806)1.97334268
141Stomach cancer (HP:0012126)1.97259154
142Mesangial abnormality (HP:0001966)1.96874460
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.96721183
144Hyperglycinuria (HP:0003108)1.96707939
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.96670847
146Hypothermia (HP:0002045)1.96262047
147Recurrent bacterial skin infections (HP:0005406)1.96213388
148Acute necrotizing encephalopathy (HP:0006965)1.94974157
149Urticaria (HP:0001025)1.94582631
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94430416
151Ventricular tachycardia (HP:0004756)1.94182898
152Progressive cerebellar ataxia (HP:0002073)1.92533555
153Hyperglycemia (HP:0003074)1.91947090
154Optic disc pallor (HP:0000543)1.91160252
155Mitochondrial inheritance (HP:0001427)1.91146550
156Genetic anticipation (HP:0003743)1.90616278
157Decreased muscle mass (HP:0003199)1.90520342
158Villous atrophy (HP:0011473)1.90154370
159Abnormality of small intestinal villus morphology (HP:0011472)1.90154370
160Stomatitis (HP:0010280)1.88963716
161Tachypnea (HP:0002789)1.88216536
162Gait imbalance (HP:0002141)1.87248619
163Ketosis (HP:0001946)1.87081872
164Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.85866861
165Chorioretinal atrophy (HP:0000533)1.85348372
166Congenital primary aphakia (HP:0007707)1.84875744
167Agitation (HP:0000713)1.84725748
168Abdominal distention (HP:0003270)1.84673138
169Increased CSF lactate (HP:0002490)1.84099701
170Progressive macrocephaly (HP:0004481)1.82351915
171Weak cry (HP:0001612)1.82060712
172Methylmalonic acidemia (HP:0002912)1.81781153
173Clumsiness (HP:0002312)1.81442469
174Severe visual impairment (HP:0001141)1.79595038
175Aplasia/Hypoplasia of the fibula (HP:0006492)1.78865852
176Abnormality of the middle phalanges of the toes (HP:0010183)1.78858299
177Bowing of the arm (HP:0006488)1.78753073
178Bowed forearm bones (HP:0003956)1.78753073
179Gonadotropin excess (HP:0000837)1.78583741
180Acute encephalopathy (HP:0006846)1.78512279
181Pterygium (HP:0001059)1.77890021
182Hypoplastic ischia (HP:0003175)1.77628542
183Absent speech (HP:0001344)1.77563500
184Natal tooth (HP:0000695)1.76443848
185Optic nerve hypoplasia (HP:0000609)1.76199144
186Methylmalonic aciduria (HP:0012120)1.74767554
187Abnormality of fatty-acid metabolism (HP:0004359)1.74699357
188Retinal dysplasia (HP:0007973)1.73765449
189Squamous cell carcinoma (HP:0002860)1.73342245
190Postaxial foot polydactyly (HP:0001830)1.72814912
191Ketoacidosis (HP:0001993)1.72250582
192Abnormal ciliary motility (HP:0012262)1.71845575
193Fair hair (HP:0002286)1.70672231
194Hyperglycinemia (HP:0002154)1.69816312
195Hypoproteinemia (HP:0003075)1.68983174
196Febrile seizures (HP:0002373)1.68371401
197Retinitis pigmentosa (HP:0000510)1.66733770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.55246331
2MAP3K144.26020889
3IRAK33.56579742
4ADRBK23.56304693
5FRK3.12078686
6IRAK42.89895335
7EPHA32.85002661
8PTK62.82171755
9ZAK2.81764625
10LATS12.79267429
11EPHB12.67321231
12MAP4K22.64909465
13ERN12.58844179
14DYRK1B2.44764677
15GRK12.37481178
16PINK12.34365406
17TLK12.32906408
18FER2.31954621
19WNK32.28840827
20TXK2.28344969
21NME12.15886045
22ERBB31.85780236
23MAPK131.81000042
24JAK31.80567228
25BCR1.75030184
26BMPR21.69648835
27KIT1.66171003
28FGFR41.64706912
29OXSR11.55216761
30NLK1.51820739
31NUAK11.47057762
32PDK41.41987549
33PDK31.41987549
34MAP3K41.41903667
35STK391.41364345
36ACVR1B1.38618596
37PTK21.36026141
38EEF2K1.34723647
39TNK21.32041535
40MAPKAPK51.31560220
41MKNK21.30056770
42TBK11.29433909
43DYRK31.28612107
44PRKCI1.27587396
45CASK1.26452632
46ADRBK11.24555475
47CHUK1.21046981
48NTRK11.20369982
49TYK21.17172100
50MAP3K71.16215334
51DYRK21.14085231
52WNK41.10392786
53IRAK11.09821961
54JAK21.09214791
55DAPK21.08909955
56NTRK31.06652333
57RPS6KB21.06240971
58FES1.03083399
59SCYL21.03008771
60LMTK21.02746322
61TIE11.00439544
62ITK0.99963519
63MUSK0.98636093
64MAPK150.98329647
65PNCK0.98323440
66LRRK20.97494766
67CDC42BPA0.97253277
68VRK10.95768482
69PLK20.95628764
70PAK30.94975070
71EIF2AK30.92882029
72PRKAA20.90246373
73PRKCG0.89402138
74MAP3K130.89247051
75IKBKE0.89033119
76TAF10.87343696
77PIK3CA0.86125742
78MAP2K70.85812796
79MST40.85683550
80DDR20.85151551
81PRKCE0.84826562
82VRK20.83618683
83PTK2B0.83415788
84BTK0.83123751
85STK38L0.82380696
86MST1R0.79968264
87PLK40.76733365
88MATK0.76500969
89TNIK0.75610039
90SIK10.74786750
91FGFR30.74700385
92MAP2K20.73747577
93PHKG10.73638650
94PHKG20.73638650
95TRIB30.73289084
96PDK20.72955925
97MKNK10.72902720
98FGFR20.71424761
99TESK10.70014482
100PKN20.66158913
101MAPKAPK30.64875283
102STK110.64873924
103JAK10.64787091
104CAMKK20.63880219
105RET0.63579250
106MET0.63314900
107MAP4K10.63013904
108GRK50.62218007
109CSNK1G20.58146982
110INSRR0.58040968
111BMPR1B0.57759028
112HIPK20.56303575
113IKBKB0.55808203
114GRK70.54765403
115ERBB20.53826090
116NME20.53145917
117RIPK40.52416965
118CSNK1G30.51853798
119STK30.51773241
120PLK30.51496518
121CSF1R0.48588979
122LYN0.47652238
123LCK0.47601152
124MAP3K20.47412842
125EPHA20.47100776
126PKN10.47037093
127PRKCH0.46700587
128CDK30.46124036
129PDGFRA0.45111213
130RPS6KA50.44159221
131PRKACA0.43968440
132MARK10.43707880
133NEK20.43122113
134CAMK2A0.42921117
135NTRK20.42794718
136CAMK10.42360950
137CSNK1A1L0.42021624
138CDK190.41728837
139CSNK1G10.40855297
140CAMK1D0.39554091
141PRKCA0.38805540
142SRC0.38334889
143BMX0.38124124
144PAK20.38040219
145CSNK1A10.37690423
146MYLK0.37669782
147PRKCQ0.36933449
148EPHA40.36622256
149MAP3K90.36533203
150WEE10.36391207
151TRPM70.35294401
152SYK0.35283263
153TAOK30.35147593
154TEC0.33562781
155TGFBR10.32426662
156RIPK10.32408123
157PIK3CG0.31741761
158PRKCD0.30220568
159MAP2K60.30150386
160CDK80.29782079
161RPS6KA10.28670721
162IGF1R0.27678562
163KSR20.27285753
164MAP2K40.27202805
165FLT30.26217419
166GRK60.25493844
167TSSK60.25126063
168MELK0.24676761

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.48944414
2Protein export_Homo sapiens_hsa030603.40261947
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.40107793
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.34511139
5Histidine metabolism_Homo sapiens_hsa003402.92889740
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.72805733
7Phototransduction_Homo sapiens_hsa047442.67230234
8Fatty acid biosynthesis_Homo sapiens_hsa000612.41217959
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41180166
10Asthma_Homo sapiens_hsa053102.35429272
11Butanoate metabolism_Homo sapiens_hsa006502.22953806
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22509873
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.16157177
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11149274
15Sulfur metabolism_Homo sapiens_hsa009202.08881987
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.05762446
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04573205
18Propanoate metabolism_Homo sapiens_hsa006401.98645415
19Caffeine metabolism_Homo sapiens_hsa002321.97868863
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.96231840
21Arginine biosynthesis_Homo sapiens_hsa002201.91661292
22RNA polymerase_Homo sapiens_hsa030201.91388449
23Nicotine addiction_Homo sapiens_hsa050331.90380328
24Oxidative phosphorylation_Homo sapiens_hsa001901.82373402
25Olfactory transduction_Homo sapiens_hsa047401.77244709
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.68367764
27Basal transcription factors_Homo sapiens_hsa030221.66904887
28Pyruvate metabolism_Homo sapiens_hsa006201.61903426
29Antigen processing and presentation_Homo sapiens_hsa046121.59407546
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47478046
31Homologous recombination_Homo sapiens_hsa034401.46278579
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43330816
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43059373
34Primary immunodeficiency_Homo sapiens_hsa053401.42196732
35Parkinsons disease_Homo sapiens_hsa050121.38587421
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33530568
37Chemical carcinogenesis_Homo sapiens_hsa052041.33466684
38Leishmaniasis_Homo sapiens_hsa051401.31504905
39Morphine addiction_Homo sapiens_hsa050321.31339178
40Phenylalanine metabolism_Homo sapiens_hsa003601.30612232
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29705036
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26555604
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25903962
44Taste transduction_Homo sapiens_hsa047421.25393056
45Fanconi anemia pathway_Homo sapiens_hsa034601.24476366
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.20153527
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18457905
48Linoleic acid metabolism_Homo sapiens_hsa005911.15847899
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12767026
50Fatty acid degradation_Homo sapiens_hsa000711.03395102
51Toxoplasmosis_Homo sapiens_hsa051451.03309822
52Tryptophan metabolism_Homo sapiens_hsa003801.02111271
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.02002498
54Cardiac muscle contraction_Homo sapiens_hsa042601.00835214
55Circadian entrainment_Homo sapiens_hsa047131.00780322
56Prolactin signaling pathway_Homo sapiens_hsa049170.97884995
57Retinol metabolism_Homo sapiens_hsa008300.96317540
58RNA degradation_Homo sapiens_hsa030180.94791126
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94631817
60N-Glycan biosynthesis_Homo sapiens_hsa005100.94047097
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93008202
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90357304
63Vitamin digestion and absorption_Homo sapiens_hsa049770.89752615
64Huntingtons disease_Homo sapiens_hsa050160.89135954
65Insulin secretion_Homo sapiens_hsa049110.89034859
66Arginine and proline metabolism_Homo sapiens_hsa003300.88852741
67Serotonergic synapse_Homo sapiens_hsa047260.88671213
68Osteoclast differentiation_Homo sapiens_hsa043800.87453121
69Purine metabolism_Homo sapiens_hsa002300.86127957
70Alzheimers disease_Homo sapiens_hsa050100.85827008
71GABAergic synapse_Homo sapiens_hsa047270.83511362
72One carbon pool by folate_Homo sapiens_hsa006700.82819801
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82108191
74Glutamatergic synapse_Homo sapiens_hsa047240.81841070
75Calcium signaling pathway_Homo sapiens_hsa040200.79276011
76African trypanosomiasis_Homo sapiens_hsa051430.78547706
77Ovarian steroidogenesis_Homo sapiens_hsa049130.78258120
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78176480
79Graft-versus-host disease_Homo sapiens_hsa053320.76717140
80Chemokine signaling pathway_Homo sapiens_hsa040620.76103722
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74362315
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73918688
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73211289
84Legionellosis_Homo sapiens_hsa051340.71147450
85Amoebiasis_Homo sapiens_hsa051460.70139706
86* Salivary secretion_Homo sapiens_hsa049700.69607396
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68941568
88Fat digestion and absorption_Homo sapiens_hsa049750.68305957
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68166047
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.66932855
91Pertussis_Homo sapiens_hsa051330.66412898
92Collecting duct acid secretion_Homo sapiens_hsa049660.66082073
93Peroxisome_Homo sapiens_hsa041460.65235419
94TNF signaling pathway_Homo sapiens_hsa046680.64627875
95Fatty acid metabolism_Homo sapiens_hsa012120.61722882
96Metabolic pathways_Homo sapiens_hsa011000.61355296
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60749324
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59634011
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58841693
100Dorso-ventral axis formation_Homo sapiens_hsa043200.58673853
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.58376730
102Autoimmune thyroid disease_Homo sapiens_hsa053200.56989077
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56929589
104ABC transporters_Homo sapiens_hsa020100.56419669
105Allograft rejection_Homo sapiens_hsa053300.56103152
106Melanoma_Homo sapiens_hsa052180.55564714
107Vibrio cholerae infection_Homo sapiens_hsa051100.55473674
108Regulation of autophagy_Homo sapiens_hsa041400.54723933
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.53300822
110Long-term depression_Homo sapiens_hsa047300.53257366
111Ribosome_Homo sapiens_hsa030100.52292655
112Pyrimidine metabolism_Homo sapiens_hsa002400.52142635
113beta-Alanine metabolism_Homo sapiens_hsa004100.51105931
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.51082960
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50976682
116Ether lipid metabolism_Homo sapiens_hsa005650.49436990
117Rheumatoid arthritis_Homo sapiens_hsa053230.49395854
118PPAR signaling pathway_Homo sapiens_hsa033200.48545622
119Biosynthesis of amino acids_Homo sapiens_hsa012300.48382170
120Gastric acid secretion_Homo sapiens_hsa049710.48027771
121Selenocompound metabolism_Homo sapiens_hsa004500.47948071
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47386064
123Hippo signaling pathway_Homo sapiens_hsa043900.47202805
124Tuberculosis_Homo sapiens_hsa051520.45276963
125Sulfur relay system_Homo sapiens_hsa041220.44037907
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43516874
127Small cell lung cancer_Homo sapiens_hsa052220.43125728
128Pancreatic secretion_Homo sapiens_hsa049720.42671697
129Pancreatic cancer_Homo sapiens_hsa052120.41479987
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41476767
131Thyroid hormone synthesis_Homo sapiens_hsa049180.40359980
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40347215
133Tight junction_Homo sapiens_hsa045300.39922597
134Hepatitis C_Homo sapiens_hsa051600.39400448
135Influenza A_Homo sapiens_hsa051640.39214932
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36694224
137Bile secretion_Homo sapiens_hsa049760.35664512
138Renin secretion_Homo sapiens_hsa049240.35535671
139Mineral absorption_Homo sapiens_hsa049780.34684852
140Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34656172
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34139907
142Apoptosis_Homo sapiens_hsa042100.33695666
143Glycerolipid metabolism_Homo sapiens_hsa005610.33676894
144Circadian rhythm_Homo sapiens_hsa047100.33325990
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33036022
146Adherens junction_Homo sapiens_hsa045200.32350025
147Galactose metabolism_Homo sapiens_hsa000520.32199497
148Arachidonic acid metabolism_Homo sapiens_hsa005900.31303024
149Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29598387
150Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28770438
151Amphetamine addiction_Homo sapiens_hsa050310.25765104
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.24108286
153Adipocytokine signaling pathway_Homo sapiens_hsa049200.23938328
154Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23016717
155Nitrogen metabolism_Homo sapiens_hsa009100.22565170
156Tyrosine metabolism_Homo sapiens_hsa003500.22195769
157Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20847120
158Insulin resistance_Homo sapiens_hsa049310.17822850
159Type I diabetes mellitus_Homo sapiens_hsa049400.17766557

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