LPP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)4.86852694
2collagen fibril organization (GO:0030199)4.58693007
3sequestering of extracellular ligand from receptor (GO:0035581)4.42050543
4regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.09866228
5regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.82274487
6cell adhesion mediated by integrin (GO:0033627)3.74147141
7wound healing, spreading of epidermal cells (GO:0035313)3.61705678
8mesenchymal-epithelial cell signaling (GO:0060638)3.59328879
9endodermal cell differentiation (GO:0035987)3.55511603
10interkinetic nuclear migration (GO:0022027)3.52862046
11regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.52051357
12pericardium development (GO:0060039)3.50304405
13endocardial cushion development (GO:0003197)3.48040654
14positive regulation of endothelial cell apoptotic process (GO:2000353)3.47071919
15protein heterotrimerization (GO:0070208)3.42861662
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.36664361
17cellular response to vitamin D (GO:0071305)3.36081502
18mesodermal cell differentiation (GO:0048333)3.24222327
19artery development (GO:0060840)3.23656156
20retina vasculature morphogenesis in camera-type eye (GO:0061299)3.23362533
21bone trabecula formation (GO:0060346)3.22663387
22skin morphogenesis (GO:0043589)3.19077676
23COPI coating of Golgi vesicle (GO:0048205)3.15545309
24Golgi transport vesicle coating (GO:0048200)3.15545309
25axon extension involved in axon guidance (GO:0048846)3.11118819
26neuron projection extension involved in neuron projection guidance (GO:1902284)3.11118819
27basement membrane organization (GO:0071711)3.06576544
28insulin-like growth factor receptor signaling pathway (GO:0048009)3.05704388
29import into cell (GO:0098657)3.05424358
30cellular response to vitamin (GO:0071295)3.04952776
31fibroblast migration (GO:0010761)3.04932999
32hippo signaling (GO:0035329)3.01389396
33regulation of hippo signaling (GO:0035330)2.96602721
34positive regulation of epithelial to mesenchymal transition (GO:0010718)2.95508108
35vascular endothelial growth factor signaling pathway (GO:0038084)2.95185136
36radial glial cell differentiation (GO:0060019)2.93685894
37endothelial cell morphogenesis (GO:0001886)2.92964340
38atrioventricular valve morphogenesis (GO:0003181)2.92340286
39iron ion import (GO:0097286)2.91996875
40craniofacial suture morphogenesis (GO:0097094)2.91458823
41smooth muscle contraction (GO:0006939)2.90917702
42negative regulation of protein localization to cell surface (GO:2000009)2.90818871
43regulation of pigment cell differentiation (GO:0050932)2.89953188
44wound healing, spreading of cells (GO:0044319)2.89082333
45negative regulation of chondrocyte differentiation (GO:0032331)2.89065850
46regulation of SMAD protein import into nucleus (GO:0060390)2.86914407
47cell migration involved in sprouting angiogenesis (GO:0002042)2.86421066
48UDP-N-acetylglucosamine metabolic process (GO:0006047)2.83538608
49desmosome organization (GO:0002934)2.81870607
50cranial suture morphogenesis (GO:0060363)2.81517988
51atrial septum morphogenesis (GO:0060413)2.81392826
52nucleus localization (GO:0051647)2.81323192
53apoptotic cell clearance (GO:0043277)2.81312642
54substrate adhesion-dependent cell spreading (GO:0034446)2.78750345
55COPII vesicle coating (GO:0048208)2.78576749
56renal filtration (GO:0097205)2.77183618
57glomerular basement membrane development (GO:0032836)2.76100585
58embryonic foregut morphogenesis (GO:0048617)2.75859373
59positive regulation of fatty acid oxidation (GO:0046321)2.74452494
60chondrocyte development (GO:0002063)2.73546838
61glomerular filtration (GO:0003094)2.73431477
62protein localization to cell surface (GO:0034394)2.72258125
63collagen metabolic process (GO:0032963)2.72256107
64maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.71577193
65regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.71569226
66hemidesmosome assembly (GO:0031581)2.71515079
67regulation of integrin-mediated signaling pathway (GO:2001044)2.66501054
68cardiac myofibril assembly (GO:0055003)2.65756560
69bundle of His cell to Purkinje myocyte communication (GO:0086069)2.63257841
70regulation of tight junction assembly (GO:2000810)2.63198191
71phospholipid translocation (GO:0045332)2.63195550
72lipid translocation (GO:0034204)2.63195550
73tonic smooth muscle contraction (GO:0014820)2.63119273
74negative regulation of fatty acid transport (GO:2000192)2.62688955
75positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.62605030
76lymph vessel development (GO:0001945)2.61201246
77positive regulation of SMAD protein import into nucleus (GO:0060391)2.60033857
78positive regulation of fatty acid beta-oxidation (GO:0032000)2.59714903
79cell migration involved in heart development (GO:0060973)2.59427043
80negative regulation of stem cell proliferation (GO:2000647)2.59235036
81neural crest cell development (GO:0014032)2.59077435
82glomerular visceral epithelial cell development (GO:0072015)2.58698395
83gland morphogenesis (GO:0022612)2.58552524
84epithelial cell-cell adhesion (GO:0090136)2.57911909
85multicellular organismal macromolecule metabolic process (GO:0044259)2.57768092
86regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.56967372
87lymphangiogenesis (GO:0001946)2.56914047
88regulation of cardiac muscle hypertrophy (GO:0010611)2.56171266
89extracellular regulation of signal transduction (GO:1900115)2.55923399
90extracellular negative regulation of signal transduction (GO:1900116)2.55923399
91collagen catabolic process (GO:0030574)2.55765414
92anterior/posterior axis specification, embryo (GO:0008595)2.55111205
93metanephric mesenchyme development (GO:0072075)2.54932820
94myofibril assembly (GO:0030239)2.54826185
95hypotonic response (GO:0006971)2.54446456
96growth hormone receptor signaling pathway (GO:0060396)2.54019331
97negative regulation of keratinocyte proliferation (GO:0010839)2.53851637
98regulation of establishment or maintenance of cell polarity (GO:0032878)2.53416546
99G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.53065553
100negative regulation of complement activation (GO:0045916)2.53056657
101lung lobe morphogenesis (GO:0060463)2.52158255
102regulation of establishment of cell polarity (GO:2000114)2.51635430
103lung vasculature development (GO:0060426)2.51579018
104smooth muscle tissue development (GO:0048745)2.51421177
105epoxygenase P450 pathway (GO:0019373)2.51372975
106cell proliferation involved in kidney development (GO:0072111)2.51074914
107multicellular organismal metabolic process (GO:0044236)2.51071555
108regulation of interleukin-8 secretion (GO:2000482)2.50958585
109extracellular matrix assembly (GO:0085029)2.49344595
110positive regulation of mesenchymal cell proliferation (GO:0002053)2.48554879
111negative regulation of cartilage development (GO:0061037)2.48142702
112regulation of muscle hypertrophy (GO:0014743)2.47131397
113regulation of heart morphogenesis (GO:2000826)2.47088560
114branching involved in prostate gland morphogenesis (GO:0060442)2.46267674
115dermatan sulfate biosynthetic process (GO:0030208)2.45988667
116extracellular matrix disassembly (GO:0022617)2.45171201
117endocrine hormone secretion (GO:0060986)2.45039379
118regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.42044702
119multicellular organismal catabolic process (GO:0044243)2.41514243
120urinary tract smooth muscle contraction (GO:0014848)2.40468597
121protein retention in ER lumen (GO:0006621)2.40194142
122cellular response to ethanol (GO:0071361)2.39901857
123cardiac muscle cell development (GO:0055013)2.39877998
124positive regulation of cardiac muscle hypertrophy (GO:0010613)2.38905775
125positive regulation of muscle hypertrophy (GO:0014742)2.38905775
126positive regulation of extracellular matrix organization (GO:1903055)2.38741248
127cell proliferation involved in metanephros development (GO:0072203)2.37794603
128kidney mesenchyme development (GO:0072074)2.37776311
129positive regulation of stem cell differentiation (GO:2000738)2.37703157
130extracellular fibril organization (GO:0043206)2.37564953
131negative regulation of protein activation cascade (GO:2000258)2.37154060
132regulation of mesenchymal cell proliferation (GO:0010464)2.37104305
133platelet-derived growth factor receptor signaling pathway (GO:0048008)2.36625526
134mesenchyme morphogenesis (GO:0072132)2.36541287
135mammary gland development (GO:0030879)2.36509415
136actin filament depolymerization (GO:0030042)2.36462449
137cardiac cell development (GO:0055006)2.35948404
138regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.35446680
139cellular response to interferon-alpha (GO:0035457)2.35199102
140regulation of cartilage development (GO:0061035)2.34529689
141regulation of transforming growth factor beta2 production (GO:0032909)2.33601626
142positive regulation of cartilage development (GO:0061036)2.33172757
143regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.31422386
144relaxation of cardiac muscle (GO:0055119)2.31266912
145positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.29778104
146regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.29411311
147positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.27740254
148regulation of protein polyubiquitination (GO:1902914)2.27055159
149actomyosin structure organization (GO:0031032)2.26865546
150macroautophagy (GO:0016236)2.24807308
151cell-substrate junction assembly (GO:0007044)2.22596234
152plasma membrane repair (GO:0001778)2.22538603
153ovulation from ovarian follicle (GO:0001542)2.19726308
154glomerular epithelial cell development (GO:0072310)2.19430605
155intestinal epithelial cell development (GO:0060576)2.16980068
156cGMP-mediated signaling (GO:0019934)2.15806636
157establishment of protein localization to Golgi (GO:0072600)2.13751270
158regulation of muscle adaptation (GO:0043502)2.13193987
159positive regulation of cardiac muscle cell differentiation (GO:2000727)2.12485337
160regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.12138995
161interleukin-6-mediated signaling pathway (GO:0070102)2.10381477
162face morphogenesis (GO:0060325)2.09423358
163negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.09157794
164negative regulation of translation, ncRNA-mediated (GO:0040033)2.09157794
165regulation of translation, ncRNA-mediated (GO:0045974)2.09157794
166response to epinephrine (GO:0071871)2.09155441
167early endosome to late endosome transport (GO:0045022)2.08540888
168blood vessel morphogenesis (GO:0048514)2.07506871
169SMAD protein complex assembly (GO:0007183)2.07315254
170fatty acid transmembrane transport (GO:1902001)2.07193810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.53448229
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.48694470
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.62845585
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.37990890
5* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.75461365
6CJUN_26792858_Chip-Seq_BT549_Human2.63174517
7* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.52433368
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.52063008
9CLOCK_20551151_ChIP-Seq_293T_Human2.51909856
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45712422
11* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38125562
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.37727251
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.35541999
14GBX2_23144817_ChIP-Seq_PC3_Human2.30008087
15* NRF2_20460467_ChIP-Seq_MEFs_Mouse2.29326160
16* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.29326160
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.26698518
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.25245862
19* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.24819242
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.22972083
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.22936017
22* BRD4_25478319_ChIP-Seq_HGPS_Human2.18726386
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16095945
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.13398302
25CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13294919
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.12332026
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.12332026
28SMAD_19615063_ChIP-ChIP_OVARY_Human2.04077089
29* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.01593499
30SALL4_18804426_ChIP-ChIP_XEN_Mouse2.00876069
31* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.95675686
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.92491559
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91299595
34SOX2_20726797_ChIP-Seq_SW620_Human1.88603906
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86768902
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.79340647
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.76123886
38TP53_18474530_ChIP-ChIP_U2OS_Human1.74353582
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73230263
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71610340
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.70917977
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.70777137
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64363933
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59805922
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.58660241
46* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.58326559
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.57866797
48* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57519012
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56124053
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.53507545
51* LXR_22158963_ChIP-Seq_LIVER_Mouse1.53062018
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52831738
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.47369135
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47284969
55TP53_16413492_ChIP-PET_HCT116_Human1.46347003
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44476121
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.43091653
58* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42493526
59AR_21572438_ChIP-Seq_LNCaP_Human1.41630789
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.41228862
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39968694
62* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39760945
63JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39236405
64* STAT3_23295773_ChIP-Seq_U87_Human1.38582016
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.38431288
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.37785137
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.37420386
68* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36798953
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34667817
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31655031
71TAF15_26573619_Chip-Seq_HEK293_Human1.31131909
72VDR_22108803_ChIP-Seq_LS180_Human1.30846854
73JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30496771
74GATA4_25053715_ChIP-Seq_YYC3_Human1.30461367
75* RXR_22158963_ChIP-Seq_LIVER_Mouse1.30295090
76P300_19829295_ChIP-Seq_ESCs_Human1.30115129
77NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.29838268
78* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29711652
79* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28376653
80* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.28234924
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28014337
82* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27640173
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27439264
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26143733
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.26073346
86SMAD3_21741376_ChIP-Seq_HESCs_Human1.25598131
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.25280273
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.24421890
89* PIAS1_25552417_ChIP-Seq_VCAP_Human1.23997635
90CDX2_20551321_ChIP-Seq_CACO-2_Human1.23634769
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23518109
92TBX20_22328084_ChIP-Seq_HEART_Mouse1.22062025
93TBX20_22080862_ChIP-Seq_HEART_Mouse1.22062025
94* TCF4_23295773_ChIP-Seq_U87_Human1.20144404
95* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19646447
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.17617491
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16273487
98* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16265074
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15930432
100TP63_23658742_ChIP-Seq_EP156T_Human1.15567559
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15498030
102BCAT_22108803_ChIP-Seq_LS180_Human1.15419576
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15082825
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14987438
105AR_25329375_ChIP-Seq_VCAP_Human1.14671355
106GATA1_22025678_ChIP-Seq_K562_Human1.14296418
107FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13686376
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13051532
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12924317
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12913211
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12704282
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12660101
113CDX2_22108803_ChIP-Seq_LS180_Human1.11912081
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11708145
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11266844
116PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10435911
117* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10005580
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07821153
119ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07582261
120* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.07513443
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.06449645
122* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06153237
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05215019
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04750637
125FUS_26573619_Chip-Seq_HEK293_Human1.04749032
126SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04675169
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03343726
128EZH2_27294783_Chip-Seq_NPCs_Mouse1.03280880
129* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02712250
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02493955
131RXR_22108803_ChIP-Seq_LS180_Human1.01003073
132TP63_19390658_ChIP-ChIP_HaCaT_Human1.00994892
133ER_23166858_ChIP-Seq_MCF-7_Human1.00760134
134NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00544733
135STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98967335
136KDM2B_26808549_Chip-Seq_REH_Human0.98916834
137* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98871408
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.98505238
139AHR_22903824_ChIP-Seq_MCF-7_Human0.98055744
140NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97035278
141TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96969256
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96653711
143* SOX2_21211035_ChIP-Seq_LN229_Gbm0.96606587
144* GATA3_24758297_ChIP-Seq_MCF-7_Human0.95846142
145* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95155152
146ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94330024
147* VDR_24787735_ChIP-Seq_THP-1_Human0.92492989
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90932791
149* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89989645
150GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88407329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.78812511
2MP0005275_abnormal_skin_tensile4.01200845
3MP0005503_abnormal_tendon_morphology3.94169802
4MP0003705_abnormal_hypodermis_morpholog3.32772148
5MP0003279_aneurysm2.96619831
6MP0004272_abnormal_basement_membrane2.88057830
7MP0009384_cardiac_valve_regurgitation2.80659114
8MP0004084_abnormal_cardiac_muscle2.36961594
9MP0000569_abnormal_digit_pigmentation2.21840594
10MP0005670_abnormal_white_adipose2.19800766
11MP0010368_abnormal_lymphatic_system2.17634773
12MP0001958_emphysema2.16975813
13MP0006054_spinal_hemorrhage2.15837802
14MP0003566_abnormal_cell_adhesion2.15442849
15MP0000462_abnormal_digestive_system1.95961875
16MP0002060_abnormal_skin_morphology1.88168903
17MP0004036_abnormal_muscle_relaxation1.88075865
18MP0000516_abnormal_urinary_system1.87516725
19MP0005367_renal/urinary_system_phenotyp1.87516725
20MP0010352_gastrointestinal_tract_polyps1.87249170
21MP0003941_abnormal_skin_development1.81944616
22MP0005257_abnormal_intraocular_pressure1.81855826
23MP0005508_abnormal_skeleton_morphology1.74201878
24MP0009053_abnormal_anal_canal1.72931468
25MP0010030_abnormal_orbit_morphology1.58810888
26MP0001879_abnormal_lymphatic_vessel1.57449479
27MP0005620_abnormal_muscle_contractility1.56880299
28MP0004215_abnormal_myocardial_fiber1.55262780
29MP0005409_darkened_coat_color1.55062518
30MP0003385_abnormal_body_wall1.54589101
31MP0002295_abnormal_pulmonary_circulatio1.51494755
32MP0009250_abnormal_appendicular_skeleto1.51338357
33* MP0005023_abnormal_wound_healing1.50318945
34MP0003091_abnormal_cell_migration1.49731606
35MP0000767_abnormal_smooth_muscle1.49196948
36MP0000230_abnormal_systemic_arterial1.48397973
37MP0003300_gastrointestinal_ulcer1.47504901
38MP0005623_abnormal_meninges_morphology1.47131665
39MP0000383_abnormal_hair_follicle1.44667975
40MP0002877_abnormal_melanocyte_morpholog1.43449610
41MP0002896_abnormal_bone_mineralization1.38840606
42MP0000751_myopathy1.37805166
43MP0000013_abnormal_adipose_tissue1.36686622
44MP0008004_abnormal_stomach_pH1.35873686
45MP0003252_abnormal_bile_duct1.34503058
46MP0003868_abnormal_feces_composition1.32231091
47MP0001661_extended_life_span1.31013936
48MP0002168_other_aberrant_phenotype1.30737155
49MP0003045_fibrosis1.27632361
50MP0002108_abnormal_muscle_morphology1.24964854
51MP0001299_abnormal_eye_distance/1.24428347
52MP0004130_abnormal_muscle_cell1.22549559
53MP0001756_abnormal_urination1.20005438
54MP0002009_preneoplasia1.19849240
55MP0001664_abnormal_digestion1.18508692
56MP0003942_abnormal_urinary_system1.17975239
57MP0008775_abnormal_heart_ventricle1.17189525
58MP0004043_abnormal_pH_regulation1.17142211
59MP0001243_abnormal_dermal_layer1.16523902
60MP0000163_abnormal_cartilage_morphology1.16442045
61MP0004484_altered_response_of1.15535655
62MP0002282_abnormal_trachea_morphology1.14305827
63MP0003828_pulmonary_edema1.11245243
64MP0003890_abnormal_embryonic-extraembry1.09665717
65MP0005248_abnormal_Harderian_gland1.08880904
66MP0002115_abnormal_skeleton_extremities1.08487721
67MP0005085_abnormal_gallbladder_physiolo1.07863742
68MP0010678_abnormal_skin_adnexa1.07706794
69MP0003115_abnormal_respiratory_system1.06915262
70MP0001542_abnormal_bone_strength1.06525477
71MP0003283_abnormal_digestive_organ1.06383422
72MP0003195_calcinosis1.05570820
73MP0005076_abnormal_cell_differentiation1.05295982
74MP0004145_abnormal_muscle_electrophysio1.02930309
75MP0005390_skeleton_phenotype1.02730004
76MP0002127_abnormal_cardiovascular_syste1.02223534
77MP0010386_abnormal_urinary_bladder0.99496128
78MP0005084_abnormal_gallbladder_morpholo0.98047036
79MP0002972_abnormal_cardiac_muscle0.97199694
80MP0000733_abnormal_muscle_development0.96577969
81MP0005330_cardiomyopathy0.95796242
82MP0000537_abnormal_urethra_morphology0.95462545
83MP0000534_abnormal_ureter_morphology0.95402488
84MP0003950_abnormal_plasma_membrane0.95155345
85MP0009780_abnormal_chondrocyte_physiolo0.94655729
86MP0000427_abnormal_hair_cycle0.94607680
87MP0002938_white_spotting0.94502967
88MP0005220_abnormal_exocrine_pancreas0.93645969
89MP0000003_abnormal_adipose_tissue0.92985221
90MP0003935_abnormal_craniofacial_develop0.92615988
91MP0003755_abnormal_palate_morphology0.90661713
92MP0002128_abnormal_blood_circulation0.90515890
93MP0002113_abnormal_skeleton_development0.89487320
94MP0009697_abnormal_copulation0.88958170
95MP0004085_abnormal_heartbeat0.88901830
96MP0002166_altered_tumor_susceptibility0.88091303
97MP0002254_reproductive_system_inflammat0.88035582
98MP0002928_abnormal_bile_duct0.86749179
99MP0003937_abnormal_limbs/digits/tail_de0.86615070
100MP0000432_abnormal_head_morphology0.86208803
101MP0010234_abnormal_vibrissa_follicle0.84584007
102MP0002932_abnormal_joint_morphology0.83869044
103MP0002933_joint_inflammation0.82767367
104MP0002998_abnormal_bone_remodeling0.81546555
105MP0002109_abnormal_limb_morphology0.81518324
106MP0000428_abnormal_craniofacial_morphol0.81357353
107MP0000566_synostosis0.81126960
108MP0000749_muscle_degeneration0.81097126
109MP0005171_absent_coat_pigmentation0.80305714
110MP0002925_abnormal_cardiovascular_devel0.79859333
111MP0002837_dystrophic_cardiac_calcinosis0.77516136
112MP0001614_abnormal_blood_vessel0.77332929
113MP0001175_abnormal_lung_morphology0.75991960
114MP0005167_abnormal_blood-brain_barrier0.75587708
115MP0002177_abnormal_outer_ear0.75300969
116MP0010630_abnormal_cardiac_muscle0.75008681
117MP0004883_abnormal_blood_vessel0.74998789
118MP0002138_abnormal_hepatobiliary_system0.74433540
119MP0005388_respiratory_system_phenotype0.74086350
120MP0002133_abnormal_respiratory_system0.74086350
121MP0005595_abnormal_vascular_smooth0.73738693
122MP0002006_tumorigenesis0.73581630
123MP0003795_abnormal_bone_structure0.73390834
124MP0000538_abnormal_urinary_bladder0.73181492
125MP0006138_congestive_heart_failure0.72754045
126MP0004134_abnormal_chest_morphology0.72309902
127MP0002098_abnormal_vibrissa_morphology0.71911041
128MP0004087_abnormal_muscle_fiber0.71836662
129MP0000249_abnormal_blood_vessel0.71039525
130MP0000266_abnormal_heart_morphology0.70932137
131MP0000762_abnormal_tongue_morphology0.70438524
132MP0003567_abnormal_fetal_cardiomyocyte0.69718475
133MP0005187_abnormal_penis_morphology0.69671021
134MP0005164_abnormal_response_to0.69450126
135MP0005408_hypopigmentation0.68691752
136MP0003453_abnormal_keratinocyte_physiol0.68403764
137MP0005174_abnormal_tail_pigmentation0.68070954
138MP0001346_abnormal_lacrimal_gland0.66759375
139MP0001533_abnormal_skeleton_physiology0.66584989
140MP0000750_abnormal_muscle_regeneration0.65731119

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.96575301
2Premature rupture of membranes (HP:0001788)5.56138203
3Aortic aneurysm (HP:0004942)4.80920723
4Aortic dissection (HP:0002647)4.67796583
5Atrophic scars (HP:0001075)3.90092911
6Shallow orbits (HP:0000586)3.73412581
7Cervical subluxation (HP:0003308)3.55001619
8Cerebral aneurysm (HP:0004944)3.50600957
9Broad metatarsal (HP:0001783)3.47440984
10Ankle contracture (HP:0006466)3.45871518
11Soft skin (HP:0000977)3.42298614
12Dilatation of the ascending aorta (HP:0005111)3.16601444
13Peritonitis (HP:0002586)3.09989104
14Fragile skin (HP:0001030)2.93298036
15Right ventricular cardiomyopathy (HP:0011663)2.91783835
16Neoplasm of the heart (HP:0100544)2.85132221
17Wormian bones (HP:0002645)2.80184789
18Osteolytic defects of the hand bones (HP:0009699)2.77216467
19Osteolytic defects of the phalanges of the hand (HP:0009771)2.77216467
20Mitral valve prolapse (HP:0001634)2.76711934
21Blue sclerae (HP:0000592)2.74529256
22Spinal cord lesions (HP:0100561)2.73046849
23Syringomyelia (HP:0003396)2.73046849
24Short 4th metacarpal (HP:0010044)2.71274803
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71274803
26Spinal rigidity (HP:0003306)2.69216943
27Follicular hyperkeratosis (HP:0007502)2.65545078
28Mesomelia (HP:0003027)2.65403542
29Vertebral compression fractures (HP:0002953)2.59813455
30Aneurysm (HP:0002617)2.59759589
31Vascular tortuosity (HP:0004948)2.59053086
32Malnutrition (HP:0004395)2.56140190
33Abnormality of dentin (HP:0010299)2.55826977
34Overgrowth (HP:0001548)2.49701926
35Increased connective tissue (HP:0009025)2.48087632
36Limited hip movement (HP:0008800)2.47832658
37Spondylolisthesis (HP:0003302)2.45415539
38Short nail (HP:0001799)2.45339711
39Neonatal short-limb short stature (HP:0008921)2.45252663
40Thin bony cortex (HP:0002753)2.44611182
41Bladder diverticulum (HP:0000015)2.42397131
42Biconcave vertebral bodies (HP:0004586)2.41315353
43Persistence of primary teeth (HP:0006335)2.33880175
44Type 1 muscle fiber predominance (HP:0003803)2.32509118
45Arterial tortuosity (HP:0005116)2.29196894
46Wide anterior fontanel (HP:0000260)2.26759787
47Camptodactyly of toe (HP:0001836)2.26594704
48Genetic anticipation (HP:0003743)2.26089582
49Abnormality of the nasal septum (HP:0000419)2.24307052
50Broad face (HP:0000283)2.21713690
51Hyperventilation (HP:0002883)2.20743738
52Abnormality of secondary sexual hair (HP:0009888)2.16049967
53Abnormality of the axillary hair (HP:0100134)2.16049967
54Tibial bowing (HP:0002982)2.10652528
55Hip contracture (HP:0003273)2.09938936
56Bell-shaped thorax (HP:0001591)2.08562688
57Hyperextensible skin (HP:0000974)2.07564736
58Fair hair (HP:0002286)2.07511115
59Wrist flexion contracture (HP:0001239)2.07098787
60Abnormality of the right ventricle (HP:0001707)2.06894999
61Asymmetry of the thorax (HP:0001555)2.05485944
62Abnormality of the 4th metacarpal (HP:0010012)2.04186073
63Genu recurvatum (HP:0002816)2.03542260
64Hyperglycemia (HP:0003074)2.03078263
65Increased density of long bones (HP:0006392)2.00325150
66Abnormality of the calf musculature (HP:0001430)2.00237613
67Elbow flexion contracture (HP:0002987)1.99895461
68Preaxial foot polydactyly (HP:0001841)1.99747595
69Bronchomalacia (HP:0002780)1.99633533
70Abnormality of the distal phalanx of the thumb (HP:0009617)1.98842399
71Mildly elevated creatine phosphokinase (HP:0008180)1.97624511
72Hypoplasia of the iris (HP:0007676)1.96422820
73Broad ribs (HP:0000885)1.95993350
74Atrial fibrillation (HP:0005110)1.95877718
75Aortic regurgitation (HP:0001659)1.95215276
76Ectopia lentis (HP:0001083)1.94804262
77Hematochezia (HP:0002573)1.94279814
78Hyporeflexia of lower limbs (HP:0002600)1.94268845
79Abnormal delivery (HP:0001787)1.93708982
80Infantile muscular hypotonia (HP:0008947)1.92609232
81Rectal prolapse (HP:0002035)1.92319827
82Striae distensae (HP:0001065)1.91072931
83Joint laxity (HP:0001388)1.90254450
84Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.89428844
85Knee flexion contracture (HP:0006380)1.89405946
86Pulmonary artery stenosis (HP:0004415)1.89217113
87Abnormality of the acetabulum (HP:0003170)1.89111294
88Mitral regurgitation (HP:0001653)1.87759073
89Decreased circulating renin level (HP:0003351)1.86041959
90Broad long bones (HP:0005622)1.83513037
91Tarsal synostosis (HP:0008368)1.82334947
92Hypoplastic ischia (HP:0003175)1.82038241
93Blue irides (HP:0000635)1.81286004
94Vertebral arch anomaly (HP:0008438)1.80755918
95Natal tooth (HP:0000695)1.80681400
96Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79935851
97Bicuspid aortic valve (HP:0001647)1.79627698
98Decreased skull ossification (HP:0004331)1.78912096
99Short hallux (HP:0010109)1.78815636
100Abnormality of the distal phalanges of the toes (HP:0010182)1.78433085
101Myocardial infarction (HP:0001658)1.76178713
102Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74922559
103Subacute progressive viral hepatitis (HP:0006572)1.74397440
104Ventricular tachycardia (HP:0004756)1.73465538
105Femoral bowing (HP:0002980)1.73232125
106Abnormality of the ischium (HP:0003174)1.73169483
107Joint contractures involving the joints of the feet (HP:0100492)1.72117226
108Flexion contracture of toe (HP:0005830)1.72117226
109Coronal craniosynostosis (HP:0004440)1.71511007
110Cardiovascular calcification (HP:0011915)1.70994694
111Absent frontal sinuses (HP:0002688)1.69666369
112Abnormality of the labia majora (HP:0012881)1.69455185
113Mitral stenosis (HP:0001718)1.67751719
114Delayed cranial suture closure (HP:0000270)1.66869647
115Hypoplastic labia majora (HP:0000059)1.66165665
116Hypoplasia of the maxilla (HP:0000327)1.65580375
117Generalized hypopigmentation of hair (HP:0011358)1.64898028
118Broad toe (HP:0001837)1.64662590
119Abnormality of skull ossification (HP:0002703)1.64640701
120Abnormality of the epiphyses of the hand (HP:0005924)1.63891513
121Scapular winging (HP:0003691)1.63382360
122Exostoses (HP:0100777)1.63162564
123Alopecia of scalp (HP:0002293)1.62205404
124Abnormality of incisor morphology (HP:0011063)1.60833523
125Platyspondyly (HP:0000926)1.60763168
126Narrow palate (HP:0000189)1.60490903
127Broad phalanx (HP:0006009)1.60196127
128Deviation of the hallux (HP:0010051)1.60094388
129Long toe (HP:0010511)1.59359787
130Abnormal biliary tract morphology (HP:0012440)1.59126457
131Aplasia/Hypoplasia of the hallux (HP:0008362)1.58104167
132Increased corneal curvature (HP:0100692)1.58053802
133Keratoconus (HP:0000563)1.58053802
134Synostosis involving bones of the feet (HP:0009140)1.57238496
135Synostosis involving bones of the lower limbs (HP:0009138)1.57238496
136Tracheomalacia (HP:0002779)1.56758998
137Dysmetric saccades (HP:0000641)1.56464548
138Hyperkalemia (HP:0002153)1.55732780
139Flat face (HP:0012368)1.53720819
140Flat acetabular roof (HP:0003180)1.53545145
141Short chin (HP:0000331)1.53217573
142Lipoatrophy (HP:0100578)1.53032527
143Tubular atrophy (HP:0000092)1.52725897
144Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.52019310
145Primary atrial arrhythmia (HP:0001692)1.51540618
146Flared iliac wings (HP:0002869)1.51370441
147Increased number of teeth (HP:0011069)1.51014248
148Syncope (HP:0001279)1.50628638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.07832383
2LATS13.83342061
3TTN3.05089438
4NUAK12.90110870
5ACVR1B2.86548129
6DDR22.73972880
7SIK12.57447868
8ZAK2.35842366
9MYLK2.32663203
10PIK3CA2.27597167
11EPHA32.11616088
12EPHB22.09752185
13PDGFRA2.09178393
14ERN12.09003445
15STK391.92349291
16STK38L1.91924919
17STK31.85887180
18DMPK1.77510051
19PIK3CG1.76461440
20NEK91.75454726
21TRPM71.73014426
22EPHA21.70087535
23PAK21.60028870
24FER1.59779803
25INSRR1.54728970
26TESK11.52135357
27ERBB31.51692356
28TGFBR21.47217167
29PTK21.40065257
30CAMK1D1.39090028
31RIPK11.38932792
32SGK21.38866551
33MET1.35977818
34PTK61.32488617
35RPS6KA41.25894010
36MST1R1.25617193
37TRIB31.23156842
38PAK31.22936306
39MAP3K31.20416468
40STK381.12617105
41MAP3K71.11549595
42LATS21.11132565
43FGFR31.09787440
44FGFR21.04893756
45AKT30.97893671
46PDGFRB0.97856490
47FGFR10.96207659
48GRK10.95911307
49CHUK0.95417465
50OBSCN0.93296235
51LRRK20.92706197
52CDC42BPA0.91630422
53SGK2230.91226567
54SGK4940.91226567
55ROCK10.90861492
56PTK2B0.90418663
57JAK10.89850018
58OXSR10.88483880
59MTOR0.87870805
60STK100.86913694
61STK240.85668685
62ADRBK10.85211356
63FLT30.82936232
64CDK60.82505849
65EEF2K0.82382468
66CDK120.80943586
67MAP3K60.80041740
68FGFR40.78484711
69PRKG20.77596654
70BMX0.77368060
71PIM20.75789996
72MAPKAPK30.74574773
73LIMK10.72698899
74CAMK1G0.70207998
75EIF2AK20.69495655
76NLK0.69156137
77JAK30.66978574
78TGFBR10.66509678
79MAP3K140.65124077
80KDR0.63073289
81BRSK20.61799287
82MKNK20.59944429
83MARK20.58793672
84MAP3K20.58255278
85PNCK0.57674304
86PRKAA10.57260381
87PKN20.56727397
88WNK10.56242652
89RPS6KA20.54489933
90MAPK70.54431608
91ERBB20.53118662
92TIE10.52021431
93ADRBK20.51978259
94RET0.50543589
95PRKAA20.49760254
96* INSR0.48170590
97PRKD20.47427730
98DYRK1B0.47093198
99CAMK10.45852822
100MUSK0.45465542
101MAPK150.43873637
102ERBB40.41607364
103PRKD10.41534481
104* IGF1R0.41380024
105IRAK30.41335696
106TNIK0.40927964
107PRKCE0.40821109
108PAK40.39870761
109MAP2K10.39799776
110CASK0.39649885
111ILK0.39504326
112LMTK20.39319262
113BCR0.38945699
114GSK3A0.38130268
115MAPKAPK20.37909954
116WNK30.37593272
117TYK20.37340671
118WNK40.35636253
119RPS6KA60.34371906
120EPHB10.34049651
121KIT0.33751706
122IKBKB0.32339788
123GRK70.32037524
124ABL10.31925288
125TEC0.31695129
126PRKG10.31684320
127CDK90.31261136
128BMPR1B0.30826530
129CAMKK20.30735444
130CAMK2D0.30383714
131MELK0.30229029
132ICK0.29611875
133SGK30.28937723
134EGFR0.28537502

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.46179953
2Adherens junction_Homo sapiens_hsa045202.86355211
3Focal adhesion_Homo sapiens_hsa045102.64835199
4TGF-beta signaling pathway_Homo sapiens_hsa043502.16940028
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.13018690
6Proteoglycans in cancer_Homo sapiens_hsa052052.11564083
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.96184174
8Protein digestion and absorption_Homo sapiens_hsa049741.92046030
9Amoebiasis_Homo sapiens_hsa051461.84968283
10Small cell lung cancer_Homo sapiens_hsa052221.83884600
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.80197966
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.78589456
13Dilated cardiomyopathy_Homo sapiens_hsa054141.77964782
14Malaria_Homo sapiens_hsa051441.72655897
15Hippo signaling pathway_Homo sapiens_hsa043901.64841377
16Histidine metabolism_Homo sapiens_hsa003401.61202610
17MicroRNAs in cancer_Homo sapiens_hsa052061.60810362
18Circadian rhythm_Homo sapiens_hsa047101.60134039
19Dorso-ventral axis formation_Homo sapiens_hsa043201.57520284
20ABC transporters_Homo sapiens_hsa020101.56756449
21Basal cell carcinoma_Homo sapiens_hsa052171.54227883
22Sulfur metabolism_Homo sapiens_hsa009201.50671757
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.49407549
24Bladder cancer_Homo sapiens_hsa052191.48283629
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.47751046
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.40596508
27Complement and coagulation cascades_Homo sapiens_hsa046101.37704143
28Renin secretion_Homo sapiens_hsa049241.35068682
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.33468311
30PI3K-Akt signaling pathway_Homo sapiens_hsa041511.31218563
31Prostate cancer_Homo sapiens_hsa052151.29396715
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29179554
33Viral myocarditis_Homo sapiens_hsa054161.20072960
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18362286
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15070355
36Toxoplasmosis_Homo sapiens_hsa051451.13089250
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.13074254
38Linoleic acid metabolism_Homo sapiens_hsa005911.12069889
39Tight junction_Homo sapiens_hsa045301.11309873
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11139845
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10730089
42Caffeine metabolism_Homo sapiens_hsa002321.10171928
43Melanoma_Homo sapiens_hsa052181.09195271
44Hedgehog signaling pathway_Homo sapiens_hsa043401.08837023
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06424867
46TNF signaling pathway_Homo sapiens_hsa046681.05528493
47Lysine degradation_Homo sapiens_hsa003101.03983820
48Pancreatic secretion_Homo sapiens_hsa049721.03184547
49Bile secretion_Homo sapiens_hsa049761.02171480
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99787246
51p53 signaling pathway_Homo sapiens_hsa041150.99711558
52Protein export_Homo sapiens_hsa030600.99426953
53Chronic myeloid leukemia_Homo sapiens_hsa052200.98200639
54Starch and sucrose metabolism_Homo sapiens_hsa005000.97954377
55Tryptophan metabolism_Homo sapiens_hsa003800.96072545
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96059647
57Fatty acid biosynthesis_Homo sapiens_hsa000610.95628288
58Pathways in cancer_Homo sapiens_hsa052000.92761984
59Insulin resistance_Homo sapiens_hsa049310.92356030
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91568329
61Fatty acid degradation_Homo sapiens_hsa000710.91233289
62PPAR signaling pathway_Homo sapiens_hsa033200.90748542
63Renin-angiotensin system_Homo sapiens_hsa046140.89743946
64Leishmaniasis_Homo sapiens_hsa051400.86048989
65Oxytocin signaling pathway_Homo sapiens_hsa049210.85489922
66Platelet activation_Homo sapiens_hsa046110.84764940
67Calcium signaling pathway_Homo sapiens_hsa040200.84306527
68Shigellosis_Homo sapiens_hsa051310.81901050
69Insulin secretion_Homo sapiens_hsa049110.80298851
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.80055216
71Glycerolipid metabolism_Homo sapiens_hsa005610.78534290
72Gastric acid secretion_Homo sapiens_hsa049710.77682511
73Salivary secretion_Homo sapiens_hsa049700.77643712
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76543931
75Chemical carcinogenesis_Homo sapiens_hsa052040.76175311
76Selenocompound metabolism_Homo sapiens_hsa004500.75304466
77Mineral absorption_Homo sapiens_hsa049780.75084784
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73406133
79cAMP signaling pathway_Homo sapiens_hsa040240.73174673
80Serotonergic synapse_Homo sapiens_hsa047260.72353767
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.72205285
82Pancreatic cancer_Homo sapiens_hsa052120.71979162
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70203127
84Wnt signaling pathway_Homo sapiens_hsa043100.69794319
85Thyroid cancer_Homo sapiens_hsa052160.69283491
86HTLV-I infection_Homo sapiens_hsa051660.68801424
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68553284
88Legionellosis_Homo sapiens_hsa051340.68526446
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67948256
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67033062
91Rap1 signaling pathway_Homo sapiens_hsa040150.66568135
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66044570
93Choline metabolism in cancer_Homo sapiens_hsa052310.65705107
94Salmonella infection_Homo sapiens_hsa051320.65240128
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.63787546
96Ether lipid metabolism_Homo sapiens_hsa005650.63655783
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.63263500
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62577437
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62572169
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62463674
101FoxO signaling pathway_Homo sapiens_hsa040680.62147665
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61947135
103Renal cell carcinoma_Homo sapiens_hsa052110.61924396
104Axon guidance_Homo sapiens_hsa043600.61442899
105Hepatitis B_Homo sapiens_hsa051610.60753895
106Arachidonic acid metabolism_Homo sapiens_hsa005900.60483935
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59064158
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58814750
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58361028
110Circadian entrainment_Homo sapiens_hsa047130.57850473
111Glucagon signaling pathway_Homo sapiens_hsa049220.57661404
112Hematopoietic cell lineage_Homo sapiens_hsa046400.56694288
113Melanogenesis_Homo sapiens_hsa049160.56463997
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.55882861
115GnRH signaling pathway_Homo sapiens_hsa049120.55725917
116Inositol phosphate metabolism_Homo sapiens_hsa005620.55193074
117Long-term depression_Homo sapiens_hsa047300.55137469
118Gap junction_Homo sapiens_hsa045400.55108209
119Galactose metabolism_Homo sapiens_hsa000520.54438926
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.54163823
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53692934
122Sphingolipid metabolism_Homo sapiens_hsa006000.53354027
123Nitrogen metabolism_Homo sapiens_hsa009100.53089703
124Apoptosis_Homo sapiens_hsa042100.52856718
125Endometrial cancer_Homo sapiens_hsa052130.52586763
126Pertussis_Homo sapiens_hsa051330.52217636
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.51739472
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51180658
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50171227
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49033992
131Staphylococcus aureus infection_Homo sapiens_hsa051500.48193188
132Vitamin digestion and absorption_Homo sapiens_hsa049770.46447868
133Phenylalanine metabolism_Homo sapiens_hsa003600.46155501
134Ovarian steroidogenesis_Homo sapiens_hsa049130.46059886
135Tyrosine metabolism_Homo sapiens_hsa003500.43814362
136HIF-1 signaling pathway_Homo sapiens_hsa040660.43728594
137Retinol metabolism_Homo sapiens_hsa008300.43487826
138Osteoclast differentiation_Homo sapiens_hsa043800.40631254
139AMPK signaling pathway_Homo sapiens_hsa041520.40593147
140Phagosome_Homo sapiens_hsa041450.40424809
141Thyroid hormone synthesis_Homo sapiens_hsa049180.40301925
142Fatty acid metabolism_Homo sapiens_hsa012120.39108816
143Fat digestion and absorption_Homo sapiens_hsa049750.38569501

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »